keyword
https://read.qxmd.com/read/38490635/a-targeted-proteomics-method-for-quantifying-plasma-apolipoprotein-kinetics-in-individual-mice-using-stable-isotope-labeling
#1
JOURNAL ARTICLE
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E Kanter, Jay W Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W Patterson, Karin E Bornfeldt
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the small amounts of blood that can be collected at sequential time points from individual mice. We describe a targeted liquid chromatography tandem mass spectrometry method for simultaneously quantifying the stable isotope enrichment of several apolipoproteins represented by multiple peptides in serial blood samples (15 μL each) obtained after retro-orbital injection of 13 C6 ,15 N2 -lysine (Lys8) in mice...
March 13, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38458338/causal-association-of-blood-lipids-with-all-cause-and-cause-specific-mortality-risk-a-mendelian-randomization-study
#2
JOURNAL ARTICLE
Jiawen Lu, Zhenqian Wang, Jiaying Zhang, Feng Jiao, Chenfeng Zou, Liyuan Han, Guozhi Jiang
Dyslipidemia has long been implicated in elevating mortality risk; yet the precise associations between lipid traits and mortality remained undisclosed. Our study aimed to explore the causal effects of lipid traits on both all-cause and cause-specific mortality. One-sample Mendelian randomization (MR) with linear and nonlinear assumptions was conducted in a cohort of 407,951 European participants from the UK Biobank. Six lipid traits, consisting of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein(a), were included to investigate the causal associations with mortality...
March 6, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38443803/prevalence-clinical-features-and-prognosis-of-familial-hypercholesterolemia-in-chinese-han-patients-with-acute-coronary-syndrome-after-a-coronary-event-a-retrospective-observational-study
#3
JOURNAL ARTICLE
Huijuan Kou, Hongtao Wang, Peng Liu, Xin Wang, Wenjing Zhu, Wei Jiang, Xiaojun Hu, Jie Deng
BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal semi-dominant disease, characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-c) from conception and accelerated atherosclerotic cardiovascular disease, often resulting in early death. The aim of this study was to evaluate the prevalence of clinically defined FH in Chinese Han patients with acute coronary syndrome (ACS) and compare the long-term prognosis of ACS patients with and without FH receiving lipid-lowering therapy containing statins after a coronary event...
March 5, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38427666/associations-between-birth-weight-and-adult-apolipoproteins-the-lifegene-cohort
#4
JOURNAL ARTICLE
Shantanu Sharma, Louise Bennet, Agne Laucyte-Cibulskiene, Anders Christensson, Peter M Nilsson
BACKGROUND: Early life factors may predict cardiovascular disease (CVD), but the pathways are still unclear. There is emerging evidence of an association of early life factors with apolipoproteins, which are linked to CVD. The study objective was to assess the associations between birth variables and adult apolipoproteins (apoA1 and apoB, and their ratio) in a population-based cohort. METHODS: The LifeGene Study is a prospective cohort comprising index participants randomly sampled from the general population...
2024: PloS One
https://read.qxmd.com/read/38417908/the-risk-of-coronary-artery-calcification-according-to-different-lipid-parameters-and-average-lipid-parameters
#5
JOURNAL ARTICLE
Tae Kyung Yoo, Mi Yeon Lee, Ki-Chul Sung
AIM: We compared the association between the baseline and average lipid parameters over time and the coronary artery calcification (CAC) risk. METHODS: Participants who underwent annual (biannual) health examinations and coronary artery computed tomography to measure CAC at least twice between March 2010 and December 2019, with a baseline CAC of 0, were included. The levels of apolipoprotein B (ApoB), Apolipoprotein A-I (ApoA1), ApoB/ApoA1, non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), TG/HDL-C, and TC/HDL-C were measured or calculated...
February 29, 2024: Journal of Atherosclerosis and Thrombosis
https://read.qxmd.com/read/38417834/association-of-apolipoprotein-levels-with-all-cause-and-cardiovascular-mortality
#6
JOURNAL ARTICLE
Jiarong Zhang, Xinru Song, Zhi Li, Haibo Xu, Haotian Shu, Jun Li, Yan Zhang
AIMS: Research has shown that apolipoproteins (Apos) are potential indicators of heart health and death. We investigated the associations of apolipoprotein levels with all-cause and cardiovascular mortality. METHODS: We systematically searched the Cochrane Library, PubMed and Web of Science for English-language studies up to November 28, 2022. We used Stata 17.0 to summarize the estimated effects with 95% confidence intervals (CIs). We also conducted subgroup analyses according to study location, year of publication, individual age, follow-up years, and sample size...
February 28, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38407584/causal-association-between-lipoproteins-and-risk-of-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-mendelian-randomization-studies
#7
REVIEW
Rongyuan Yang, Shirong Wu, Zhen Zhao, Xuanxuan Deng, Qiuying Deng, Dawei Wang, Qing Liu
OBJECTIVE: To systematically evaluate the causal effect of lipoproteins to the risk of coronary artery disease (CAD) by systematic review and meta-analysis of the associated Mendelian randomization (MR) studies. METHODS: This systematic review was registered in PROSPERO (ID CRD42023465430). Searches from the databases (e.g., PubMed, Embase, Cochrane, Web of Science) and non-database sources to collect MR studies. The search time frame was from the database inception to August 2023...
February 26, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38396488/could-tumor-necrosis-factor-serve-as-a-marker-for-cardiovascular-risk-factors-and-left-ventricular-hypertrophy-in-patients-with-early-onset-coronary-artery-disease
#8
JOURNAL ARTICLE
Marta Białecka, Violetta Dziedziejko, Krzysztof Safranow, Andrzej Krzystolik, Zuzanna Marcinowska, Dariusz Chlubek, Monika Rać
Introduction: Tumor necrosis factor (TNF), a pro-inflammatory cytokine, can be produced by cardiomyocytes, leading to metabolic disorders in the myocardium. The objective of this study was to assess the relationship between plasma levels of the TNF cytokine and the presence of known biochemical and clinical risk factors for cardiovascular disease, along with the parameters of cardiac morphology in patients diagnosed with coronary artery disease (CAD) at a young age. Materials and Methods: The study group included 75 men aged up to 50 years and 25 women aged up to 55 years...
February 18, 2024: Diagnostics
https://read.qxmd.com/read/38393015/apob100-and-atherosclerosis-what-s-new-in-the-21st-century
#9
REVIEW
Dimitris Kounatidis, Natalia G Vallianou, Aikaterini Poulaki, Angelos Evangelopoulos, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Maria Dalamaga
ApoB is the main protein of triglyceride-rich lipoproteins and is further divided into ApoB48 in the intestine and ApoB100 in the liver. Very low-density lipoprotein (VLDL) is produced by the liver, contains ApoB100, and is metabolized into its remnants, intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL). ApoB100 has been suggested to play a crucial role in the formation of the atherogenic plaque. Apart from being a biomarker of atherosclerosis, ApoB100 seems to be implicated in the inflammatory process of atherosclerosis per se...
February 12, 2024: Metabolites
https://read.qxmd.com/read/38360457/trends-in-epidemiology-of-dyslipidemias-in-india
#10
JOURNAL ARTICLE
Sonali Sharma, Kiran Gaur, Rajeev Gupta
Dyslipidemias are the most important coronary artery disease (CAD) risk factor. High total cholesterol and its principal subtypes: low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (NHDL) cholesterol are the most important. Epidemiological and Mendelian randomization studies have confirmed role of raised triglycerides and lipoprotein(a). INTERHEART study reported a significant association of raised ApoB/ApoA1, total-, LDL-, and NHDL-cholesterol in South Asians. Prospective Urban Rural Epidemiology (PURE) study identified raised NHDL cholesterol as the most important risk factor...
February 12, 2024: Indian Heart Journal
https://read.qxmd.com/read/38324182/discovery-and-exploration-of-lipid-modifying-drug-targets-for-als-by-mendelian-randomization
#11
JOURNAL ARTICLE
Zheng Jiang, Xiao-Jing Gu, Wei-Ming Su, Qing-Qing Duan, Kang-Fu Yin, Yan-Lin Ren, Yi Wang, Bei Cao, Yong-Ping Chen
Observational studies have faced challenges in identifying replicable causes for amyotrophic lateral sclerosis (ALS). To address this, we employed an unbiased and data-driven approach to discover and explore potential causal exposures using two-sample Mendelian randomization (MR) analyses. In the phenotype discovery stage, we assessed 3948 environmental exposures from the UK Biobank and utilized ALS summary statistics (Europeans, 20,806 cases, 59,804 controls) as the outcome within a phenome-wide MR pipeline...
February 7, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38322516/-%C3%AF-75-g-a-polymorphism-of-apolipoprotein-a1-gene-promoter-region-in-normal-pregnant-women-and-patients-with-gestational-diabetes-mellitus
#12
JOURNAL ARTICLE
Ruoyu Li, Huai Bai, Linbo Guan, Xinghui Liu, Ping Fan, Mi Zhou, Yujie Wu, Yufeng Wang, Zhengting Zhu, Guoyu Wang, Yonghong Wang, Dehua Li
OBJECTIVE: To investigate the -75 G/A single-nucleotide polymorphism in the promoter region of apolipoprotein A1 gene ( apoA 1) and its association with gestational diabetes mellitus (GDM) in pregnant women and to provide references for the exploration in the molecular genetic basis of GDM. METHODS: A total of 626 GDM patients and 1022 normal pregnant women, ie, the controls, were included in the study. The genotyping of apoA 1 -75 G/A polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis...
January 20, 2024: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/38310324/revisiting-an-old-relationship-the-causal-associations-of-the-apob-apoa1-ratio-with-cardiometabolic-diseases-and-relative-risk-factors-a-mendelian-randomization-analysis
#13
JOURNAL ARTICLE
Chao Fu, Dongbo Liu, Qi Liu, Xuedong Wang, Xiaoxue Ma, Hong Pan, Shi Feng, Zhao Sun, Weishen Qiao, Mengyue Yang, Shuang Gao, Hongyu Ding, Xingtao Huang, Jingbo Hou
BACKGROUND: It has been confirmed that the ApoB/ApoA1 ratio is closely associated with the incidence of cardiometabolic diseases (CMD). However, due to uncontrolled confounding factors in observational studies, the causal relationship of this association remains unclear. METHODS: In this study, we extracted the ApoB/ApoA1 ratio and data on CMD and its associated risk factors from the largest European Genome-Wide Association Study. The purpose was to conduct Mendelian Randomization (MR) analysis...
February 3, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38292140/apoa1-apob-apoa1-b-for-pathogenic-prediction-of-chronic-obstructive-pulmonary-disease-complicated-by-acute-lower-respiratory-tract-infection-a-cross-sectional-study
#14
JOURNAL ARTICLE
Jiaqi Meng, Weichang Yang, Ziyong Chen, Caixia Pei, Xinmin Peng, Can Li, Fengyuan Li
PURPOSE: To investigate the value of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ApoA1/B ratio in pathogenic diagnosis of chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infection, assisting comprehensive disease assessment. PATIENTS AND METHODS: The study enrolled 171 COPD patients with acute lower respiratory tract infections, 35 COPD patients without acute lower respiratory tract infections, and 41 healthy controls...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38281009/apolipoproteins-and-the-risk-of-giant-cell-arteritis-a-nested-case-control-study
#15
JOURNAL ARTICLE
Karin Wadström, Lennart T H Jacobsson, Aladdin J Mohammad, Kenneth J Warrington, Eric L Matteson, Carl Turesson
BACKGROUND: The etiology of giant cell arteritis (GCA) and its predictors are incompletely understood. Previous studies have indicated reduced risk of future development of GCA in individuals with obesity and/or diabetes mellitus. There is limited information on blood lipids before the onset of GCA. The objective of the study was to investigate the relation between apolipoprotein levels and future diagnosis of GCA in a nested case-control analysis. METHODS: Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Diet Cancer Study; N = 30,447) were identified by linking the health survey database to the local patient administrative register and the national patient register...
January 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38265339/cetp-gene-polymorphisms-and-haplotypes-are-explanatory-variables-for-hdl-cholesterol-level-in-sickle-cell-disease
#16
JOURNAL ARTICLE
N R C Cruz, T N S Valente, F O Ferreira, L R Macedo, A R Belisário, C M da Silva, N S Oliveira, A F F Gomides, C Velloso-Rodrigues
Variations in lipid profile have been observed in sickle cell disease (SCD) and understanding their relationship with disease severity is crucial. This study aimed to investigate the association of polymorphisms of the CETP gene and laboratory markers of disease severity with lipid profile in a pediatric population with SCD. Biochemical and anthropometric analyses and CETP and alpha-thalassemia genotyping were performed. The study included 133 children and adolescents with sickle cell anemia (SCA) or hemoglobin SC disease (SCC), in steady-state...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38251965/heme-oxygenase-2-genetic-variants-alter-hormonal-and-metabolic-traits-in-polycystic-ovary-syndrome
#17
JOURNAL ARTICLE
Xinyuan Zhang, Suiyan Li, Hongwei Liu, Huai Bai, Qingqing Liu, Chunyi Yang, Ping Fan
Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role in preserving heme metabolism as well as in modulating glycolipid metabolism, oxidative stress, and inflammation. This study examined the correlation between HMOX2 G554A(rs1051308) and A-42G(rs2270363) genetic variants with the risk of PCOS and assessed the effects of these genotypes on clinical, hormonal, metabolic, and oxidative stress indices using a case-control design that included 1014 patients with PCOS and 806 control participants...
January 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38211689/serum-apolipoproteins-and-mortality-risk-evidence-from-observational-and-mendelian-randomization-analyses
#18
JOURNAL ARTICLE
Jiacong Li, Xianxiu Ge, Xinyi Liu, Chengqu Fu, Junyan Miao, Wei Zhao, Lin Miao, Dong Hang
BACKGROUND: Apolipoproteins (APOs) have emerged as significant players in lipid metabolism that affects the risk of chronic disease. However, the impact of circulating APO concentrations on premature death remains undetermined. OBJECTIVE: To investigate the associations of serum APOs with all-cause, cardiovascular disease (CVD), and cancer mortality. METHODS: We included 340,737 participants who had serum APO measurements from the UK Biobank...
January 9, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38161051/lipid-profile-and-nt-probnp-changes-from-pre-clinical-to-established-rheumatoid-arthritis-a-12-years-follow-up-explorative-study
#19
JOURNAL ARTICLE
Reinder Raadsen, Bas Dijkshoorn, Laurette van Boheemen, Edwin Ten Boekel, Arno W R van Kuijk, Michael T Nurmohamed
OBJECTIVES: The aim of the current study was to explore the changes in lipid and NT-proBNP levels in rheumatoid arthritis (RA) patients through different phases of the disease: from the preclinical stage and RA onset up to the treatment phase with biological disease-modifying anti-rheumatic drugs (bDMARDS). METHODS: Thirty-eight consecutive patients, initially with arthralgia and rheumatoid factor and/or anti-citrullinated protein antibodies without arthritis, who later developed RA and eventually started treatment with bDMARDs, were included...
December 29, 2023: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/38143756/the-analysis-of-serum-lipids-profile-in-guillain-barre-syndrome
#20
JOURNAL ARTICLE
Lijuan Wang, Yaowei Ding, Jie Liu, Guanghui Zheng, Siwen Li, Wencan Jiang, Kelin Chen, Xin Luan, Yuxin Chen, Siqi Wang, Guojun Zhang
BACKGROUND: Guillain-Barre syndrome (GBS) is an immune-mediated inflammatory peripheral neuropathy. This study aimed to conduct a systematic analysis of the serum lipids profile in GBS. METHODS: We measured the serum lipids profile in 85 GBS patients and compared it with that of 85 healthy controls matched for age and sex. Additionally, we analyzed the correlation between lipids and the severity, subtypes, precursor infections, clinical outcomes, clinical symptoms, immunotherapy, and other laboratory markers of GBS...
2023: Frontiers in Immunology
keyword
keyword
62360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.