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Vitality skin forensic

Jie-Tao He, Hong-Yan Huang, Dong Qu, Ye Xue, Kai-Kai Zhang, Xiao-Li Xie, Qi Wang
Detection of the vitality of wounds is one of the most important issues in forensic practice. This study investigated mRNA and protein levels of CXCL1 and CXCR2 in skin wounds in mice and humans. Western blot analysis of CXCL1 and CXCR2 protein levels showed no difference between wounded and intact skin. However, mRNA levels demonstrated higher expression of CXCL1 and CXCR2 in contused mouse and human skin, compared with intact skin. At postmortem there were no remarkable changes in CXCL1 and CXCR2 mRNA levels in contused mouse skin...
April 2, 2018: Forensic Science, Medicine, and Pathology
Yuko Ishida, Yumi Kuninaka, Mizuho Nosaka, Emi Shimada, Satoshi Hata, Hiroki Yamamoto, Yumiko Hashizume, Akihiko Kimura, Fukumi Furukawa, Toshikazu Kondo
In forensic practices, it is often difficult to determine wound vitality in compression marks of the neck with naked eyes. AQP1 and AQP3 are the major water channels associated with skin. Thus, we immunohistochemically examined the expression of AQP1 and AQP3 in neck skin samples to discuss their forensic applicability to determination of the wound vitality. Skin samples were obtained from 56 neck compression cases (hanging, 35 cases; strangulation, 21 cases). The intact skin from the same individual was taken as a control...
January 22, 2018: International Journal of Legal Medicine
Mona M Abo El-Noor, Fatma M Elgazzar, Hanan A Alshenawy
Estimation of age and vitality of burn injury both in the living and dead is essential in forensic practice. Nitric oxide and interleukin-6 (IL-6) play an important role in skin burn healing. In this study, the expression of inducible nitric oxide synthase (iNOS) and IL-6 proteins during skin burn healing in rats was studied for purposes of burn dating and to differentiate between ante-mortem and post-mortem burn. Ante-mortem skin burns were created on forty five rats. Normal and burnt skin samples were taken at 1, 3, 5, 7, 9, 11, 13, 15 and 21 days following burn induction (5 rats for each stage)...
November 2017: Journal of Forensic and Legal Medicine
Céline Leccia, Véronique Alunni, Gérald Quatrehomme
Decapitation following suicidal hanging is rarely encountered in forensic practice. The authors report a case of suicidal hanging resulting in decapitation following a fall of 5m. This case is compared with 30 cases found in the literature. Several factors including type of rope, skin abrasion, level of the severed vertebrae, thyroid cartilage and hyoid bone injuries and vital signs are studied. The force applied to the neck and the kinetic energy were calculated. The kinetic energy (ranging from 1820 to 7310J) takes into account the weight of the victim but also the length of the rope (height of the fall)...
October 2017: Forensic Science International
Isabel Legaz Pérez, Maria Falcón, M Gimenez, F Martínez Diaz, M D Pérez-Cárceles, E Osuna, D Nuno-Vieira, A Luna
Ascertaining the vital origin of skin wounds is one of the most challenging problems in forensic pathology. The forensic literature describes biomarkers and methods for differentiating vital and postmortem wounds, although no clear conclusions have been reached. The aim of this study was to characterize human vital wounds by analyzing the concentrations of metallic ions and the expression of P-selectin and cathepsin D in skin wounds in the ligature marks in a cohort of suicidal hangings for which vitality was previously demonstrated...
September 2017: American Journal of Forensic Medicine and Pathology
Luiz Eduardo Toledo Avelar, Márcio Alberto Cardoso, Leonardo Santos Bordoni, Lorena de Miranda Avelar, João Victor de Miranda Avelar
BACKGROUND: The aging process of the face comprises all layers: skin, subcutaneous fat, muscles, and skeleton, and the signs of aging depend mainly on which layer is mostly affected. OBJECTIVE: To evaluate the aging facial skeleton, as well as establish the sexual differences, areas with a strong predisposition to resorption, and aesthetic repercussion for better treatment approach. METHODS: Skulls from the Forensic Anthropology Department of the Institute of Forensic Medicine of Belo Horizonte, Brazil, were classified according to gender and age group (i...
April 2017: Plastic and Reconstructive Surgery. Global Open
Pierre-Antoine Peyron, Éric Baccino, Nicolas Nagot, Sylvain Lehmann, Constance Delaby
Determination of skin wound vitality is an important issue in forensic practice. No reliable biomarker currently exists. Quantification of inflammatory cytokines in injured skin with MSD(®) technology is an innovative and promising approach. This preliminary study aims to develop a protocol for the preparation and the analysis of skin samples. Samples from ante mortem wounds, post mortem wounds, and intact skin ("control samples") were taken from corpses at the autopsy. After an optimization of the pre-analytical protocol had been performed in terms of skin homogeneisation and proteic extraction, the concentration of TNF-α was measured in each sample with the MSD(®) approach...
February 1, 2017: Annales de Biologie Clinique
T Radhika, Nadeem Jeddy, S Nithya
Tongue is a vital internal organ well encased within the oral cavity and protected from the environment. It has unique features which differ from individual to individual and even between identical twins. The color, shape, and surface features are characteristic of every individual, and this serves as a tool for identification. Many modes of biometric systems have come into existence such as fingerprint, iris scan, skin color, signature verification, voice recognition, and face recognition. The search for a new personal identification method secure has led to the use of the lingual impression or the tongue print as a method of biometric authentication...
September 2016: Journal of Forensic Dental Sciences
Kristiane Barington, Henrik Elvang Jensen
Recognizing post-mortem (PM) changes is of crucial importance in veterinary forensic pathology. In porcine wounds established PM contradicting observations regarding infiltration of leukocytes have been described. In the present study, skin, subcutis and muscle tissue sampled from experimental pigs with PM incised wounds (n=8), PM bruises (n=8) and no lesions, i.e. controls (n=4), were examined for signs of vitality over time. All tissue samples were subjected to gross and histopathological evaluation. Hemorrhages were present along the edges of PM incised wounds but deposits of fibrin were never observed...
June 2017: Research in Veterinary Science
Leigh Hlavaty, Sarah Avedschmidt, Kelly Root, Jeffrey Amley, LokMan Sung
Proper interpretation of gunshot wounds is vital for the forensic pathologist and requires experience and expertise, as well as consultation with a firearms and ballistics expert and careful scene investigation in cases of atypical gunshot wounds. This study is the first large-series examining ricochet gunshot wounds involving different firearm calibers. Typical gunshot wounds created from 4 handgun calibers (22 Long Rifle, 9 × 19 mm Parabellum, .40 Smith &Wesson, and .45 Automatic Colt Pistol) and 2 rifle calibers (5...
December 2016: American Journal of Forensic Medicine and Pathology
L Ressel, U Hetzel, E Ricci
Veterinary pathologists commonly encounter lesions of blunt trauma. The development of lesions is affected by the object's mass, velocity, size, shape, and angle of impact and by the plasticity and mobility of the impacted organ. Scrape, impact, and pattern abrasions cause localized epidermal loss and sometimes broken hairs and implanted foreign material. Contusions are best identified after reflecting the skin, and must be differentiated from coagulopathies and livor mortis. Lacerations-traumatic tissue tears-may have irregular margins, bridging by more resilient tissue, deviation of the wound tail, crushed hairs, and unilateral abrasion...
September 2016: Veterinary Pathology
Khurshid A Mattoo, Rishabh Garg, Shalabh Kumar
CONTEXT: This study is a continuation of the earlier studies and has been extended to investigate the potential forensic markers of elder abuse. AIMS: To determine the prevalence of elder abuse in various outpatient departments (OPDs). To study the associated parameters related to the abuser and the abused. To determine the existence of potential forensic markers of elder abuse. SETTINGS AND DESIGN: The subjects were randomly selected from the medical and the dental OPDs of the university...
September 2015: Journal of Forensic Dental Sciences
Jean-Matthieu Casse, Laurent Martrille, Jean-Michel Vignaud, Guillaume Gauchotte
Wound age evaluation is one of the most challenging issues in forensic pathology. In the first minutes or hours, standard histological examination may not determine whether the wound was inflicted in the pre- or post-mortem period. While red blood cell infiltration is classically considered as a sign of vital reaction, several studies have shown that extravasation of blood cells may also occur after death and cannot be used as a reliable marker in the diagnosis of wound vitality. Numerous studies about wound vitality are available in the literature...
April 2016: Medicine, Science, and the Law
Biji T Kurien, Debashish Danda, R Hal Scofield
Dactyloscopy or fingerprint identification is a vital part of forensic evidence. Identification with fingerprints has been known since the finding of finger impressions on the clay surface of Babylonian legal contracts almost 4,000 years ago. The skin on the fingers and palms appears as grooves and ridges when observed under a microscope. A unique fingerprint is produced by the patterns of these friction skin ridges. Visible fingerprints can be deposited on solid surfaces. Colored inks have been used to deposit fingermarks on documents...
2015: Methods in Molecular Biology
(no author information available yet)
Hanging is a form of ligature strangulation in which the force applied to the neck is derived from the gravitational drag of one's own body weight. A furrow-dessication is the most common form of ligature mark on the skin. The furrow is a postmortem phenomenon due to ligature pressure and it is more detectable as the suspension time becomes longer.Vital reaction is a phenomenon that shows if the injury was pre- mortal. Vital signs could be present at the injury site, thus it is termed as local, but they could also be remote from the injury site, and then they are termed general vital signs...
January 2015: Srpski Arhiv za Celokupno Lekarstvo
Akihiko Kimura, Yuko Ishida, Mizuho Nosaka, Maiko Shiraki, Mizuki Hama, Takashi Kawaguchi, Yumi Kuninaka, Emi Shimada, Hiroki Yamamoto, Tatsunori Takayasu, Toshikazu Kondo
Detection of vitality of mechanical wounds in human cadavers is one of the important issues in forensic medicine. In order to explore novel markers for vitality of acute mechanical wounds, we investigated autophagy in mouse and human skin wounds. Western blotting analysis of mouse skin wounds showed marked reduction of LC3-II and reciprocal increase of p62 in wound samples with the postinfliction intervals of ≥0.5 h, compared with the uninjured skin tissues. These observations indicated that autophagy level was reduced in the wound sites...
May 2015: International Journal of Legal Medicine
S Bacci, B Defraia, L Cinci, L Calosi, D Guasti, L Pieri, V Lotti, A Bonelli, P Romagnoli
The response to wounds until healing requires the activity of many cell types coordinate in space and time, so that the types of cells in a wound and their localization may be of help to date lesions with respect to death, which would be useful in forensic pathology. Cells reacting to injury include dendritic cells; the early reaction of these cells to skin wounding has not yet been investigated in humans, which was the aim of this study. Samples of wounded and control skin were taken at autopsy and analyzed by affinity histochemistry...
November 2014: Forensic Science International
Franklin R W van de Goot, H Ibrahim Korkmaz, Judith Fronczek, Birgit I Witte, Rob Visser, Magda M W Ulrich, Mark P V Begieneman, Lawrence Rozendaal, Paul A J Krijnen, Hans W M Niessen
PURPOSE OF THE STUDY: In forensic autopsies it is important to determine the age of early vital skin wounds as accurate as possible. In addition to inflammation, coagulation is also induced in vital wounds. Analysis of blood coagulation markers in wound hemorrhage could therefore be an important additional discriminating factor in wound age determination. The aim of this study was to develop a wound age probability scoring system, based on the immunohistochemical expression levels of Fibronectin, CD62p and Factor VIII in wound hemorrhage...
November 2014: Forensic Science International
Massimo Montisci, Matteo Corradin, Luciano Giacomelli, Guido Viel, Giovanni Cecchetto, Santo Davide Ferrara
Markers of skin wound vitality and the research methodology used for their determination are still matters of debate in forensic pathology. Cathepsin-D, a lysosomal enzyme, is the most expressed cathepsin in human skin, and although it seems to have the necessary requirements to be utilized as a vitality marker, past research has provided no definitive and clear response on its potential usefulness. Immunohistochemistry with monoclonal antibodies and image analysis has been employed to detect and quantify the expression of Cathepsin-D in human skin wounds...
July 2014: Medicine, Science, and the Law
Guillaume Gauchotte, Marie-Pierre Wissler, Jean-Matthieu Casse, Julien Pujo, Christophe Minetti, Héloïse Gisquet, Charlène Vigouroux, François Plénat, Jean-Michel Vignaud, Laurent Martrille
The timing of skin wounds is one of the most challenging problems in forensic pathology. In the first minutes or hours after infliction, histological examination fails to determine whether a wound was sustained before or after death. The aim of this study was to evaluate the use of three immunohistochemical markers (FVIIIra, CD15, and tryptase) for the interpretation of the timing of cutaneous stab wounds. We evaluated these markers in intravital wounds from autopsy cases (n = 12) and surgical specimens (n = 58)...
September 2013: International Journal of Legal Medicine
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