Sabrina Malik, Govindaiah Vinukonda, Linnea R Vose, Daniel Diamond, Bala B R Bhimavarapu, Furong Hu, Muhammad T Zia, Robert Hevner, Nada Zecevic, Praveen Ballabh
Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimester of pregnancy and that preterm birth would suppress neurogenesis. To test our hypotheses, we evaluated autopsy materials from human fetuses and preterm infants of 16-35 gestational weeks (gw). We noted that both cycling and noncycling Sox2(+) radial glial cells and Tbr2(+) intermediate progenitors were abundant in human preterm infants until 28 gw...
January 9, 2013: Journal of Neuroscience