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https://www.readbyqxmd.com/read/28225968/atypical-cellular-blue-nevus-or-malignant-blue-nevus
#1
Luise Ribeiro Daltro, Lygia Bertalha Yaegashi, Rodrigo Abdalah Freitas, Bruno de Carvalho Fantini, Cacilda da Silva Souza
Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented lesion in the buttock since birth, but with progressive growth in the last two years. After surgical excision, histopathological examination revealed atypical cellular blue nevus...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28225967/synchronous-melanomas-arising-within-nevus-spilus
#2
Maria Helena Toda Sanches de Brito, Cecília Silva Nunes de Moura Dionísio, Cândida Margarida Branco Martins Fernandes, Joana Cintia Monteiro Ferreira, Maria Joaninha Madalena de Palma Mendonça da Costa Rosa, Maria Manuela Antunes Pecegueiro da Silva Garcia
Nevus spilus is a melanocytic cutaneous lesion consisting of a light brown background macule with numerous superimposed darker maculopapular speckles. Melanoma arising from a nevus spilus is rare, with less than 40 cases reported to date. The absolute risk for malignant transformation is not well defined, lacking a standardized management approach. We report a new case of melanoma arising from nevus spilus, with the additional peculiarity of multifocality. We offer our recommendations for the management of the condition...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28223745/intense-pulsed-light-alone-and-in-combination-with-erbium-yttrium-aluminum-garnet-laser-on-small-to-medium-sized-congenital-melanocytic-nevi-single-center-experience-based-on-retrospective-chart-review
#3
Mi So Lee, Hee Jin Jun, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
BACKGROUND: Treatment of congenital melanocytic nevi (CMN) with intense pulsed light (IPL) has recently produced promising results. OBJECTIVE: To evaluate the clinical and histological outcomes of small-to-medium sized CMN treated with IPL alone and in combination with erbium: yttrium-aluminum-garnet (Er: YAG) laser. METHODS: We performed a retrospective chart review of 26 small-to-medium sized CMN treated as described above. The reduction in visible pigmentation, signs of recurrence and any adverse skin changes were evaluated by two independent clinicians...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223743/dermoscopic-features-of-small-medium-and-large-sized-congenital-melanocytic-nevi
#4
Fatma Pelin Cengiz, Nazan Emiroglu, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
BACKGROUND: Congenital melanocytic nevi (CMN) are present at birth. It is well known that the presence of large-sized congenital nevus in early life could predict a major risk of developing melanoma. OBJECTIVE: To investigate the clinical and dermoscopic features of the CMN, to search for and highlight any differences between small-sized, medium-sized, large-sized CMN. METHODS: A nonrandomized observational study was performed. A total of 108 melanocytic nevi were analysed by clinical and dermoscopic examination...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28221180/sebaceous-carcinoma-arising-within-a-nevus-sebaceus-excised-by-mohs-micrographic-surgery
#5
Wesley Wu, Gunjan M Modi, Mohsin R Mir, Divya Srivastava
No abstract text is available yet for this article.
February 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28218335/nevoid-malignant-melanoma-a-diagnosis-of-a-nevus-that-you-later-regret
#6
Grigorios Theodosiou, Iva Johansson, Nils Hamnerius, Åke Svensson
is missing (Short communication).
February 20, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28216737/eccrine-angiomatous-hamartoma-in-a-patient-with-nevus-depigmentosus-and-nevus-spilus
#7
Toshiyuki Yamamoto, Maki Hirano, Kazuki Ueda
No abstract text is available yet for this article.
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28212542/two-stage-genome-wide-association-study-identifies-a-novel-susceptibility-locus-associated-with-melanoma
#8
Katherine J Ransohoff, Wenting Wu, Hyunje G Cho, Harvind C Chahal, Yuan Lin, Hong-Ji Dai, Christopher I Amos, Jeffrey E Lee, Jean Y Tang, David A Hinds, Jiali Han, Qingyi Wei, Kavita Y Sarin
Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-stage genome-wide association study of melanoma. The stage 1 discovery phase consisted of 4,842 self-reported melanoma cases and 286,565 controls of European ancestry from the 23andMe research cohort and the stage 2 replication phase consisted of 1,804 melanoma cases and 1,026 controls from the University of Texas M...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28210186/bilateral-retinitis-pigmentosa-with-unilateral-choroidal-nevus-a-hitherto-unreported-association
#9
Rupak Roy, Kumar Saurabh, Debmalya Das, Preeti Sharma, Avirupa Ghose, Dhileesh P Chandrasekharan
Retinitis Pigmentosa (RP) has been reported to be associated with retinal hemangioma, retinal angiomatous proliferation, polypoidal choroidal vasculopathy and vasoproliferative tumours. However there is no previous report of choroidal nevus in an eye with RP. We describe such a case in which the eye with RP had a choroidal nevus at the macula. The coexistence of these two entities in the same eye emphasizes the need of careful examination of patients with RP. The presence of choroidal nevus warrants additional investigations such as B scan ultrasonography and a close follow-up to pick up changes in the nevus size and morphology...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28207006/papillary-transitional-cell-bladder-carcinoma-and-systematized-epidermal-nevus-syndrome
#10
Adekemi Akingboye, Heather Schultz, Gina A Taylor
Epidermal nevus syndrome (ENS), also known as Solomon syndrome, is a rare neurocutaneous disorder defined by mosaicism. Epidermal nevus syndrome may be associated with a variety of systemic findings, several of which have been described in the literature, including but not limited to central nervous system abnormalities and internal malignancies. There is a paucity of reports of patients with both epidermal nevi and papillary transitional cell bladder carcinoma in the literature. We present a rare case of systematized epidermal nevi associated with development of papillary transitional cell bladder carcinoma in a young woman...
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28203156/papular-epidermal-nevus-with-skyline-basal-cell-layer-syndrome-natural-course-case-report-and-literature-review
#11
Carole Anouk Zahn, Peter Itin
Papular epidermal nevus with "skyline" basal cell layer (PENS) is a very rare type of keratinocytic nevus and is associated with extracutaneous findings such as neurological symptoms in about 50% of the cases. Therefore, it is also referred to as PENS syndrome. Clinically visible hyperkeratotic papules and plaques already appear at birth or shortly thereafter, while neurological symptoms such as epilepsy and mental retardation manifest themselves during childhood. Genetics suggests gonadal mosaicism as a possible cause for the disease...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28198069/ultrapulse-carbon-dioxide-laser-treatment-for-bilateral-facial-nevus-comedonicus-a-case-report
#12
Caiyong Zhu, Aijuan Sun
Nevus comedonicus (NC), a rare skin ailment with an aggregation of dilated follicular orifices filled with keratinous material, is difficult to treat. Several drugs have been assessed for the treatment of NC, but with limited success. Surgery requires much experience and the recurrence rate is high. Various types of laser have been tried, with promising outcomes. A 54-year-old male patient with bilateral facial NC was admitted on July 8, 2014. A coin-sized area was first treated successfully with ultrapulse CO2 laser...
February 15, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28196213/ugly-duckling-sign-as-a-major-factor-of-efficiency-in-melanoma-detection
#13
Caroline Gaudy-Marqueste, Yanal Wazaefi, Yvane Bruneu, Raoul Triller, Luc Thomas, Giovanni Pellacani, Josep Malvehy, Marie-Françoise Avril, Sandrine Monestier, Marie-Aleth Richard, Bernard Fertil, Jean-Jacques Grob
Importance: Understanding the contribution of the ugly duckling sign (a nevus that is obviously different from the others in a given individual) in intrapatient comparative analysis (IPCA) of nevi may help improve the detection of melanoma. Objectives: To assess the agreement of dermatologists on identification of the ugly duckling sign and estimate the contribution of IPCA to the diagnosis of melanoma. Design, Setting, and Participants: The same 2089 digital images of the nevi of a sample of 80 patients (mean age, 42 years [range, 19-80 years]; 33 men and 47 women), as well as 766 dermoscopic images from a subset of 30 patients (mean age, 40 years [range, 21-75 years]; 12 men and 18 women), were randomly presented to the same 9 dermatologists for blinded assessment from September 22, 2011, to April 1, 2013...
February 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28191661/combined-in-vivo-reflectance-confocal-microscopy-and-digital-dermoscopy-for-follow-up-of-patients-at-high-risk-of-malignant-melanoma-a-prospective-case-series-study
#14
Uxúa Floristán Muruzábal, Reyes Gamo Villegas, Ana Pampín Franco, Fernando Pinedo Moraleda, Elia Pérez Fernández, José Luis López-Estebaranz
Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. In this prospective study, performed over 22 months, changing melanocytic lesions were detected by DD and excised. RCM imaging was performed before surgical excision of all the lesions, and histopathology used as the gold standard diagnostic test...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28188086/two-intermittent-vismodegib-dosing-regimens-in-patients-with-multiple-basal-cell-carcinomas-mikie-a-randomised-regimen-controlled-double-blind-phase-2-trial
#15
Brigitte Dréno, Rainer Kunstfeld, Axel Hauschild, Scott Fosko, David Zloty, Bruno Labeille, Jean-Jacques Grob, Susana Puig, Frank Gilberg, Daniel Bergström, Damian R Page, Gary Rogers, Dirk Schadendorf
BACKGROUND: Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved for use in adults with advanced basal-cell carcinoma. Patients with multiple basal-cell carcinomas, including those with basal-cell nevus (Gorlin) syndrome, need extended treatment. We assessed the safety and activity of two long-term intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas. METHODS: In this randomised, regimen-controlled, double-blind, phase 2 trial, we enrolled adult patients with multiple basal-cell carcinomas, including those with basal-cell nevus syndrome, who had one or more histopathologically confirmed and at least six clinically evident basal-cell carcinomas...
February 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28178365/development-and-clinical-validation-of-a-novel-photography-based-skin-erythema-evaluation-system-a-comparison-with-the-calculated-consensus-of-dermatologists
#16
M Cho, D-H Lee, E J Doh, Y Kim, J H Chung, H C Kim, S Kim
Erythema is the most common presenting sign of skin conditions [1,2]. Erythema reflects the degree of inflammation associated with various diseases, such as atopic dermatitis, psoriasis, and lupus erythematosus; it is also cosmetically troublesome in subjects with flushing, rosacea, and photoaging [3,4]. In addition, there are vascular disorders that present with erythema, such as nevus flammeus, telangiectasia, and post-acne erythema [5]. Various therapeutic devices, medicines, and cosmetics have been developed to improve these dermatological conditions [6,7]...
February 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28166613/melanocytic-nevus-count-and-dermoscopic-features-do-not-differ-in-psoriatic-patients-undergoing-biological-agent-versus-conventional-drug-therapy
#17
Serpil Pirmit, Nahide Onsun, Ozlem Su, Dilek B Ozkaya
BACKGROUND: Psoriasis is a chronic immune-mediated disease and treatment of psoriasis includes conventional immunosuppressive agents and biological agents. There are a few data on the relationship between psoriasis and melanocytic lesions. Either benign or malignant proliferations may be seen with immunosuppressive treatment. Eruptive nevi and malignant melanoma (MM) have been reported also associated with biological agents There is raising link biological treatment and malignancies. The objective of this paper is to examine the effects of biological agents versus conventional drugs on melanocytic nevi count and dermoscopical features...
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28163452/outcome-of-flap-surgeries-in-dermatosurgical-unit-at-a-tertiary-care-centre-in-india-with-a-review-of-literature
#18
Gorur Kalappa Divya, Kanathur Shilpa, Sacchidanand Sarvajnamurthy, Eswari Loganathan, Biju Vasudevan, G B Chitrika, C Madhura, D V Lakshmi
INTRODUCTION: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit. MATERIALS AND METHODS: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Data were recorded for each case including age, sex, indications and type of flap surgery and any occurrence of complications...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28161919/cysts-of-the-iris-pigment-epithelium-what-is-new-and-interesting-the-2016-jose-rizal-international-medal-lecture
#19
REVIEW
Jerry A Shields, Carol L Shields
PURPOSE: Cysts of the iris pigment epithelium (IPE) can involve the pupillary margin, midzone, or peripheral location or can be free-floating in the aqueous or vitreous or lodged in the anterior chamber angle. Avariant of IPE cyst, known as iris flocculi, can be a marker for systemic thoracic aneurysm. DESIGN: Review of IPE cysts and description of new observations of the lesions. METHODS: Review of IPE cysts. RESULTS: Lesions in 672 eyes were classified as of the pupillary margin (n = 49; 7%), midzone (n = 188; 28%), peripheral (n = 424; 63%), or dislodged/free-floating (n = 11; 2%)...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#20
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
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