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https://www.readbyqxmd.com/read/28632950/fibroblastic-connective-tissue-nevus-clinicopathological-and-immunohistochemical-study-of-14-cases
#1
Ilaria Pennacchia, Heinz Kutzner, Dmitry V Kazakov, Thomas Mentzel
BACKGROUND: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labelled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS: Eight patients were male and five were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Histologically, all cases were composed of bundles of bland spindle cells of fibroblastic/myofibroblastic lineage irregularly branching within the reticular dermis and along fibrous septa in the subcutis...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28631119/-expression-of-cancer-testis-ct-antigens-in-pediatric-and-adolescent-melanomas
#2
REVIEW
N Behrendt, T Schultewolter, K Busam, D Frosina, G Spagnoli, A Jungbluth
BACKGROUND: One of the main problems in the diagnostics of pediatric melanomas is the differentiation from benign dermal lesions typical for this age group, such as Spitz nevus. The biological behavior of pediatric melanomas differs considerably from that of melanomas in adults. MATERIAL AND METHODS: Cancer testis (CT) antigens are named after their typical expression pattern since they are present in various types of malignant tumors but in normal adult tissues are solely expressed in testicular germ cells...
June 19, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28630029/malignant-transformation-of-multifocal-tapioca-iris-nevus-in-a-child
#3
Maxwell R Harley, Raksha Rao, Sara E Lally, Carol L Shields
No abstract text is available yet for this article.
June 16, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28625464/becker-s-nevus-and-lethal-beta-actin-mutations
#4
Rudolf Happle
The etiology of Becker's nevus and Becker's nevus syndrome has been until now unknown. Cai et al. provide evidence that these disorders are caused by lethal mutations in ACTB, a gene coding for beta-actin. They hypothesize that these mutations may interfere with Hedgehog pathway signaling. Their findings have important implications for clinical genetics, and they open new aspects in hair research.
June 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28622423/-congenital-dermatofibrosarcoma-protuberans-clinically-mimicking-a-melanocytic-nevus-treated-with-serial-excisions
#5
J Laske, M Sergon, T Mentzel, S Beissert, J Maschke
A 9-year-old female patient was referred to our department with the clinical diagnosis of a congenital melanocytic nevus on the back for serial excisions. The child's parents confirmed that the lesion existed since birth. Only little changes in color and size were observed over the years. The lesion was painless. This article is protected by copyright. All rights reserved.
June 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28604751/melanocytic-nevi-and-melanoma-unraveling-a-complex-relationship
#6
REVIEW
W E Damsky, M Bosenberg
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi. Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF(V600E)-activating mutations, will never progress to melanoma. Herein, we synthesize basic scientific insights and data from mouse models with common observations from clinical practice to comprehensively review melanocytic nevus biology. In particular, we focus on the mechanisms by which growth arrest is established after BRAF(V600E) mutation...
June 12, 2017: Oncogene
https://www.readbyqxmd.com/read/28599417/overexpression-of-the-anti-apoptotic-protein-bag3-in-human-choroidal-melanoma-a-case-report
#7
Tatsuya Yunoki, Yoshiaki Tabuchi, Takashi Kondo, Yoko Ishii, Atsushi Hayashi
Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), exerts anti-apoptotic effects in various malignant tumors. However, relationships between choroidal melanoma and BAG3 are poorly studied. This study investigated the expression of BAG3 in a case of human choroidal melanoma. Funduscopy, computed tomography, and single-photon emission computed tomography with the intravenous injection of N-isopropyl-p-[(123)I] iodoamphetamine strongly indicated choroidal melanoma in a 68-year-old woman...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28593303/factors-in-early-adolescence-associated-with-a-mole-prone-phenotype-in-late-adolescence
#8
Haoming Xu, Michael A Marchetti, Stephen W Dusza, Esther Chung, Maira Fonseca, Alon Scope, Alan C Geller, Marilyn Bishop, Ashfaq A Marghoob, Allan C Halpern
Importance: Nevi are important phenotypic risk factors for melanoma in adults. Few studies have examined the constitutional and behavioral factors associated with a mole-prone phenotype in adolescents. Objective: To identify host, behavioral, and dermoscopic factors in early adolescence (age, 14 years) that are associated with a mole-prone phenotype in late adolescence (age, 17 years). Design, Setting, and Participants: A prospective observational cohort study from the Study of Nevi in Children was conducted from January 1, 2009, to December 31, 2014, with a 2- to 3-year follow-up...
June 7, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28591278/comparisons-of-choroidal-nevus-measurements-obtained-using-10-and-20-mhz-ultrasound-and-spectral-domain-optical-coherence-tomography
#9
Maíra de França Martins, Kelcia Kiefer, Liliane Almeida Andrade Kanecadan, Patricia Novita Garcia, Rubens N Belfort, Norma Allemann
Purpose: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US). Methods: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results)...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28580411/recurrent-halo-nevus-dermoscopy-and-confocal-microscopy-features
#10
Ana Carolina Porto, Tatiana Pinto Blumetti, Raquel de Paula Ramos Castro, Clovis Antônio Lopes Pinto, Adriana Silveira Pessoa Mendes, João Pedreira Duprat Neto, Gisele Gargantini Rezze, Juliana Casagrande Tavoloni Braga
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28579218/choroidal-nevus-or-melanoma-choroidal-neovascularisation-as-a-confounder-in-choroidal-nevus
#11
O Subira, H Brosa, D Lorenzo, J M Caminal
No abstract text is available yet for this article.
May 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28574612/basal-cell-carcinoma-pathogenesis-and-therapy-involving-hedgehog-signaling-and-beyond
#12
Anshika Bakshi, Sandeep C Chaudhary, Mehtab Rana, Craig A Elmets, Mohammad Athar
Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling related proteins. Recent genomic studies point to the involvement of additional genetic mutations that might be associated with the development of BCCs, suggesting significance of other signaling pathways, such as WNT, NOTCH, mTOR, and Hippo, aside from hedgehog in the pathogenesis of this human neoplasm...
June 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28570484/optical-coherence-tomography-angiography-features-of-choroidal-neovascularization-associated-with-choroidal-nevus
#13
Marco Pellegrini, Federico Corvi, Emil A T Say, Carol L Shields, Giovanni Staurenghi
PURPOSE: To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging. METHODS: Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain OCT, and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and spectral domain OCT...
May 29, 2017: Retina
https://www.readbyqxmd.com/read/28567312/intracorneal-hematoma-showing-clinical-and-dermoscopic-features-of-acral-lentiginous-melanoma
#14
Ugur Uslu, Franz Heppt, Michael Erdmann
Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28566917/some-becker-s-nevus-melanocytes-remain-alive-after-treatment-with-q-switched-alexandrite-laser
#15
Han Jin Jung, Sun Young Moon, Mi Yeung Sohn, Yong Hyun Jang, Seok-Jong Lee, Do Won Kim, Weon Ju Lee
No abstract text is available yet for this article.
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28565919/age-and-anatomical-location-related-dermoscopic-patterns-of-210-acral-melanocytic-nevi-in-a-turkish-population
#16
Nazan Emiroglu, Fatma Pelin Cengiz, Nahide Onsun
BACKGROUND: Dermoscopy is a useful tool for earlier diagnosis and differentiating benign lesions from melanoma. OBJECTIVES: We aim to investigate dermoscopic features of acral nevi, age, and localisation-related findings of these lesions. METHODS: This was an observational, descriptive study. Patients were retrospectively collected from the Department of Dermatology. The patients with acral nevi were included in the study. Inclusion criteria were Turkish nationality and the presence of at least 1 acral nevus diagnosed both clinically and dermoscopically...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28562437/use-of-skin-biopsies-among-dermatologists
#17
David A Weinstein, Sasank Konda, Brett M Coldiron
BACKGROUND: Skin biopsies are essential to establish a diagnosis in many skin diseases. Utilization has been increasing rapidly and represents a significant health care cost. There are no benchmarks or baselines to guide the practice of skin biopsies. OBJECTIVE: To create a reference data set of biopsy behavior among dermatologists. METHODS: Five hundred eighty-eight dermatologists belonging to the American Dermatological Association (ADA) were surveyed...
May 25, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28560218/dermoscopic-analysis-of-nevus-sebaceus-of-jadassohn-a-study-of-13-cases
#18
Awatef Kelati, Hanane Baybay, Salim Gallouj, Fatima Zahra Mernissi
BACKGROUND: Nevus sebaceus of Jadassohn (NSJ) is a complex cutaneous hamartoma with various clinical appearances. AIM: To describe different dermoscopic patterns of this nevus according to its evolutionary stages. METHODS: This was an analytical study of NSJ carried out in the Department of Dermatology at the University Hospital Hassan II, Fez, Morocco. RESULTS: Thirteen patients with a NSJ were enrolled in the study...
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28554764/pigmented-trichoblastoma-developed-in-a-sebaceous-nevus-hras-mutation-as-a-common-molecular-driver
#19
Deborah Saraggi, Roberto Salmaso, Elisa Valentini, Giada Munari, Vincenzo Vindigni, Massimo Rugge, Matteo Fassan, Lorenzo Cerroni
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
March 30, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28543313/congenital-atrophic-plaque-fibroblastic-connective-tissue-nevus
#20
Luis Jesús Allemant Ortiz, Ximena Calderón-Castrat, Alex Orellana Cortez, Beatriz Ingar Carbone, Angel Santos-Briz
Fibroblastic connective tissue nevus (FCTN) is a rare, benign, dermal mesenchymal hamartoma that affects children. We report a 15-year-old boy with a congenital FCTN and describe the clinical, dermatoscopic, and histopathologic features.
May 23, 2017: Pediatric Dermatology
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