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https://www.readbyqxmd.com/read/29332123/braf-nras-and-gnaq-mutations-in-conjunctival-melanocytic-nevi
#1
Jasmine H Francis, Hans E Grossniklaus, Larissa A Habib, Brian Marr, David H Abramson, Klaus J Busam
Purpose: To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods: Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all blue nevi, a hybridization capture-based next-generation sequencing method was employed for mutation analysis...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331035/noninvasive-optical-spectroscopy-for-identification-of-non-melanoma-skin-cancer-pilot-study
#2
David J Carpenter, Mirabelle B Sajisevi, Nikita Chapurin, Clifford Scott Brown, Tracy Cheng, Gregory M Palmer, Daniel S Stevenson, Caroline L Rao, Russell P Hall, Charles R Woodard
OBJECTIVE: Optical spectroscopy offers a noninvasive alternative to biopsy as a first-line screening tool for suspicious skin lesions. This study sought to define several optical parameters across malignant and benign tissue types. STUDY DESIGN: Prospective pilot trial utilizing the Zenalux IM1 optical spectroscopy device from April 2016 to February 2017. For each skin lesion, provider pre-biopsy probability of malignancy was compared to histolopathologic diagnosis...
January 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29316280/giant-congenital-melanocytic-nevus-with-vascular-malformation-and-epidermal-cysts-associated-with-a-somatic-activating-mutation-in-braf
#3
Heather C Etchevers, Christian Rose, Birgit Kahle, Helmuth Vorbringer, Frédéric Fina, Pauline Heux, Irina Berger, Benjamin Schwarz, Stéphane Zaffran, Nicolas Macagno, Sven Krengel
Giant congenital melanocytic nevi may be symptomatically isolated, or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year old patient with a giant congenital melanocytic nevus of the lower back, buttocks and thighs was asymptomatic except for unexpected hemorrhage during partial surgical excision years before. Blunt trauma at age 64 initiated recurrent, severe pain under the nevus; multiple large epidermal cysts then developed within it...
January 5, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29314292/examination-of-the-melanocytes-of-the-nevus-of-ota-with-in-vivo-reflectance-confocal-microscopy-15-cases
#4
Christoph Grechenig, Elisa Cinotti, Bruno Labeille, Gerald Langmann, Jean Luc Perrot, Olivia Schatz, Lisa Tarmann, Andreas Wedrich, Werner Wackernagel, Iris Zalaudek, Johannes Haybaeck, Christoph Schwab
The Nevus of Ota (NO) is a bluish or greyish hyperpigmentation caused by an accumulation of dermal melanocytes that typically extend to the innervated parts of the ophthalmic and maxillary divisions of the trigeminal nerve, involving the facial skin, the uvea, the iris and the sclera (Figure 1). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29314193/acral-pigmented-spitz-nevus-in-a-child-with-transepidermal-migration-of-melanocytes-dermoscopic-and-reflectance-confocal-microscopic-features
#5
Christopher Iriarte, Babar Rao, Attiya Haroon, Anna Yasmine Kirkorian
Acral pigmented Spitz nevi are seldom reported in the literature. We report a new case on the palm of a 4-year-old girl that demonstrated correlation between features observed on dermoscopy and reflectance confocal microscopy (RCM). Histopathology revealed a benign intraepidermal Spitz nevus with transepidermal elimination of melanocytes that showed on RCM as focal atypical bright cells concerning for malignancy. This case is one of few reports in the literature combining dermoscopy, reflectance confocal microscopy, and histology for an acral Spitz nevi, which are rarely evaluated by RCM given the thickness of the stratum corneum in acral sites...
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29309239/meyerson-nevus
#6
Evangelia Panagou, Kara Heelan
No abstract text is available yet for this article.
January 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29299693/picosecond-532-nm-neodymium-doped-yttrium-aluminum-garnet-laser-a-promising-modality-for-the-management-of-verrucous-epidermal-nevi
#7
Assi Levi, Dan Ben Amitai, Daniel Mimouni, Yael A Leshem, Ofir Arzi, Moshe Lapidoth
The verrucous epidermal nevus (VEN) is the most common type of epidermal nevi. As lesions can be disfiguring, treatment is often sought. Many therapeutic approaches have been reported, with variable efficacy and safety. Picosecond (PS) lasers are novel laser devices designated to target small chromophores. A side effect of these lasers is blistering due to epidermal-dermal separation. We aimed to harness this side effect of the PS lasers to treat patients with VEN. The purpose of this study was to report our experience treating VEN using a PS 532-nm laser...
January 3, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29290322/-nevus-lipomatosus-cutaneous-superficialis-report-of-four-cases-including-an-unusual-presentation-associated-with-massive-lipomas-and-diffuse-lipomatosis
#8
Mariana Medell-Gago, Tamara Guerra-Guerra, Orlando González-Pérez, Leonardo Concepción-Quiñones
Nevus lipomatosus cutaneus superficialis is a rare, hamartomatous disorder, characterized by the presence of ectopic mature adipose tissue within the superficial dermis. Lesions occur within the first three decades of life. We report four new cases, including a patient with the most extensive affectation reported to date, which was associated with massive lipomas in the subcutaneous cell tissue and diffuse lipomatosis. To our knowledge, it is the first report of this disorder in Cuba.
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29288102/a-split-face-single-blinded-randomized-controlled-comparison-of-alexandrite-755-nm-picosecond-laser-vs-alexandrite-755-nm-nanosecond-laser-in-the-treatment-of-acquired-bilateral-nevus-of-ota-like-macules-abnom
#9
Wenyou Yu, Jiafang Zhu, Wenxin Yu, Dongze Lyu, Xiaoxi Lin, Zhen Zhang
BACKGROUND: Q-switched alexandrite lasers (QSAL) have been used for the treatment of acquired bilateral nevus of Ota-like macules (ABNOM). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL in the treatment of ABNOM. OBJECTIVE: To compare the efficacy and safety of a PSAL and a QSAL in the treatment of ABNOM. METHODS: Each patient (n = 30) received three treatments at six-month intervals...
December 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29282187/cellular-blue-nevus-an-unusual-localization
#10
Murat Zor, Engin Kaya
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/29250649/inflammatory-juvenile-compound-conjunctival-nevi-a-clinicopathological-study-and-literature-review
#11
Claudia Florida Costea, Mihaela Dana Turliuc, Gabriela Dimitriu, Camelia Margareta Bogdănici, Anca MoŢoc, Mădălina Adriana Chihaia, Cristina Dancă, Andrei Cucu, Alexandru Cărăuleanu, Nicoleta Dumitrescu, Lucia Indrei, Şerban Turliuc
AIM: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, "Prof...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29241739/braf-and-kras-mutations-in-tubular-apocrine-adenoma-and-papillary-eccrine-adenoma-of-the-skin
#12
Jau-Yu Liau, Jia-Huei Tsai, Wen-Chang Huang, Jui Lan, Jin-Bon Hong, Chang-Tsu Yuan
Tubular apocrine adenoma (TAA) and papillary eccrine adenoma (PEA) are benign sweat gland tumors. Their names imply that they exhibit apocrine and eccrine differentiation, respectively. However, morphologically they are very similar and are often indistinguishable. The molecular pathogenesis of either tumor is poorly understood at present. On the basis of an index case of nipple adenoma that was morphologically reminiscent of cutaneous TAA/PEA and harbored a BRAFV600E mutation, we investigated whether a similar genetic change is also present in TAA/PEA...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29230331/the-successful-treatment-of-a-case-of-linear-psoriasis-with-ixekizumab
#13
Sara Ghoneim, Alvaro J Ramos-Rodriguez, Fernando Vazquez de Lara, Lauren Bonomo
Linear psoriasis is an unusual clinical variation of psoriasis that manifests segmentally along the lines of Blaschko. A major differential diagnosis is inflammatory linear verrucous epidermal nevus (ILVEN). The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. We report a case of a 25-year-old African-American female who presented with asymptomatic hyperkeratotic papules along the lines of Blaschko and was subsequently diagnosed with linear psoriasis...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29228734/cutaneous-melanoma-primary-site-is-linked-to-nevus-density
#14
Alejandro Martin-Gorgojo, Marta Llinares, Amaya Virós, Celia Requena, Zaida Garcia-Casado, Víctor Traves, Rajiv Kumar, Eduardo Nagore
There are at least two pathways driving cutaneous melanoma; one is linked to an inherent melanoma susceptibility to nevi development and the second to environmental cumulative ultraviolet light exposure. In this study, we examined the relation between nevus density, accrued sun damage and the site of primary melanoma excision. In a series of 888 consecutive cutaneous melanoma patients, melanomas appearing in skin areas with a high relative nevus density were most prominent in men, with an elevated nevus count, at sites without solar elastosis, but with an epidemiological history of previous sunburn...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29225224/characterization-of-melanin-radicals-in-paraffin-embedded-malignant-melanoma-and-nevus-pigmentosus-using-x-band-epr-and-epr-imaging
#15
Kouichi Nakagawa, Satoko Minakawa, Daisuke Sawamura, Hideyuki Hara
Continuous wave electron paramagnetic resonance (CW EPR) and X-band (9 GHz) EPR imaging (EPRI) were used to nondestructively investigate the possible differentiation between malignant melanoma (MM) and nevus pigmentosus (NP) melanin radicals in paraffin-embedded specimens. The EPR spectra of both samples were analyzed using linewidth, spectral pattern, and X-band EPRI. The CW-EPR spectra of the MM showed an additional signal overlap. Eumelanin- and pheomelanin-related radicals were observed in the MM specimens...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29215322/aberrant-sirt6-expression-contributes-to-melanoma-growth-role-of-the-autophagy-paradox-and-igf-akt-signaling
#16
Liwen Wang, Weinan Guo, Jinyuan Ma, Wei Dai, Lin Liu, Sen Guo, Jiaxi Chen, Huina Wang, Yuqi Yang, Xiuli Yi, Gang Wang, Tianwen Gao, Guannan Zhu, Chunying Li
Melanoma is among the most life-threatening cancer. The pathogenesis of melanoma has not been fully elucidated. Recently, dysregulated macroautophagy/autophagy has been found to play a critical but inconsistent role in modulating melanoma growth at different stages, with the regulatory mechanism unclear. The histone deacetylase SIRT6 (sirtuin 6) is a known autophagy regulator, and its involvement in cancer development has been reported. Therefore, we sought to determine the role of SIRT6 in melanoma growth and detect its possible link with autophagy in the current study...
December 7, 2017: Autophagy
https://www.readbyqxmd.com/read/29210482/genomic-analysis-of-a-case-of-agminated-spitz-nevi-and-congenital-pattern-nevi-arising-in-extensive-nevus-spilus
#17
Caitlin Porubsky, Jamie K Teer, Yonghong Zhang, Maria Deschaine, Vernon Sondak, Jane L Messina
Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi that underwent genetic analysis to further characterize the mutational profile of this rare entity.
December 6, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29206289/contiguous-verrucous-proliferations-in-syringocystadenoma-papilliferum-a-retrospective-analysis-with-additional-evaluation-via-mutation-specific-brafv600e-immunohistochemistry
#18
Ben J Friedman, Joya Sahu, Charalambos C Solomides, Deirdre M Connolly, Jason B Lee
BACKGROUND: Syringocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal proliferation. There have been several reports describing collision lesions of SCAP and verruca, although little is known about the frequency of this association. Molecular testing has revealed the BRAFV600E mutation in a large proportion of SCAP cases, although its expression pattern has not been previously evaluated. METHODS: In this retrospective analysis, we explored the potential histopathological association between verruca and SCAP...
December 5, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29204211/unusual-cause-of-west-syndrome
#19
Ananthanarayanan Kasinathan, Hansashree Padmanabh, Kirti Gupta, Naveen Sankhyan, Paramjeet Singh, Pratibha Singhi
Schimmelpenning-Feuerstein-Mims syndrome is a congenital neurocutaneous disorder, comprising of organoid epidermal nevus with a broad spectrum of multiorgan dysfunction (neurologic, skeletal, cardiovascular, ophthalmic, and urologic) secondary to postzygotic mutation in the early embryonic period. Predominant neurological manifestations include epilepsy, intellectual impairment, and focal deficits. Here, we report a 3-year-old girl who presented with epileptic spasms and had a characteristic linear sebaceous nevus...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29201456/use-of-oct-angiography-in-choroidal-melanocytic-tumors
#20
Juan J Toledo, Mónica Asencio-Duran, Jesús R García-Martinez, Alejandro López-Gaona
Objective: To describe OCTA findings in choroidal melanocytic tumors, especially the microcirculation patterns, and to try to correlate with the histopathological studies. Methods: Cross-sectional, comparative, observational study. 70 cases, including 55 choroidal nevi and 15 choroidal melanomas. Three different observers evaluated specific variables in the choriocapillaris layer on AOCT images and searched for images which described histopathologic vascular patterns, and also, a general description of the images was made...
2017: Journal of Ophthalmology
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