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Keywords Collaborative Pediatric Critic...

Collaborative Pediatric Critical Care Research Network

https://read.qxmd.com/read/36692622/pediatric-biobanks-to-enhance-clinical-and-translational-research-for-children
#21
REVIEW
Alessandra Cianflone, Fabio Savoia, Rosanna Parasole, Peppino Mirabelli
Including children in biomedical research is an argument for continual reflection and practice refinement from an ethical and legal standpoint. Indeed, as children reach adulthood, a reconsent method should be used, and data connected with samples should ideally be updated based on the children's growth and long-term results. Furthermore, because most pediatric disorders are uncommon, children's research initiatives should conform to standard operating procedures (SOPs) set by worldwide scientific organizations for successfully sharing data and samples...
January 24, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/36661432/leveraging-clinical-informatics-and-data-science-to-improve-care-and-facilitate-research-in-pediatric-acute-respiratory-distress-syndrome-from-the-second-pediatric-acute-lung-injury-consensus-conference
#22
REVIEW
L Nelson Sanchez-Pinto, Michaƫl Sauthier, Prakadeshwari Rajapreyar, Werther Brunow de Carvalho, Philippe Jouvet, Christopher Newth
OBJECTIVES: The use of electronic algorithms, clinical decision support systems, and other clinical informatics interventions is increasing in critical care. Pediatric acute respiratory distress syndrome (PARDS) is a complex, dynamic condition associated with large amounts of clinical data and frequent decisions at the bedside. Novel data-driven technologies that can help screen, prompt, and support clinician decision-making could have a significant impact on patient outcomes. We sought to identify and summarize relevant evidence related to clinical informatics interventions in both PARDS and adult respiratory distress syndrome (ARDS), for the second Pediatric Acute Lung Injury Consensus Conference...
February 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36521013/adverse-events-in-pediatric-critical-care-nonsurvivors-with-a-low-predicted-mortality-risk-a-multicenter-case-control-study
#23
MULTICENTER STUDY
Carin W Verlaat, Marieke Zegers, Richard Klein, Dick van Waardenburg, Jan Willem Kuiper, Maaike Riedijk, Martin Kneyber, Brigitte Timmers, Marc van Heerde, Jan A Hazelzet, Johannes van der Hoeven, Joris Lemson
OBJECTIVES: Some patients with a low predicted mortality risk in the PICU die. The contribution of adverse events to mortality in this group is unknown. The aim of this study was to estimate the occurrence of adverse events in low-risk nonsurvivors (LN), compared with low-risk survivors (LS) and high-risk PICU survivors and nonsurvivors, and the contribution of adverse events to mortality. DESIGN: Case control study. Admissions were selected from the national Dutch PICU registry, containing 53,789 PICU admissions between 2006 and 2017, in seven PICUs...
January 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36454002/pediatric-acute-lung-injury-and-sepsis-investigators-palisi-evolution-of-an-investigator-initiated-research-network
#24
JOURNAL ARTICLE
Adrienne G Randolph, Melania M Bembea, Ira M Cheifetz, Martha A Q Curley, Heidi R Flori, Robinder G Khemani, Sapna R Kudchadkar, Akira Nishisaki, R Scott Watson, Marisa Tucci, Jacques Lacroix, Ann E Thompson, Neal J Thomas
The Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network originated over 20 years ago to foster research to optimize the care of critically ill infants and children. Over this period, PALISI has seen two major evolutions: formalization of our network infrastructure and a broadening of our clinical research focus. First, the network is unique in that its activities and meetings are funded by subscriptions from members who now comprise a multidisciplinary group of investigators from over 90 PICUs all over the United States (US) and Canada, with collaborations across the globe...
December 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36376987/transitions-from-pediatric-to-adult-rheumatology-care-for-juvenile-idiopathic-arthritis-a-patient-led-qualitative-study
#25
JOURNAL ARTICLE
Gillian R Currie, M Harris, L McClinton, N Trehan, A Van Dusen, M Shariff, T Kuzmyn, D A Marshall
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a childhood autoimmune disease that causes swelling and pain in at least one joint. Young people with JIA experience symptoms that persist into adulthood, and thus will undergo a transition including the o transfer of care from a pediatric rheumatologist an adult rheumatologist. Missing from the literature is research that centres the transition experience of young people with JIA in Canada. This goal of this patient-led research was to explore the experience young people with JIA through the process of transition...
November 14, 2022: BMC rheumatology
https://read.qxmd.com/read/36343185/the-united-kingdom-paediatric-critical-care-society-study-group-the-20-year-journey-toward-pragmatic-randomized-clinical-trials
#26
MULTICENTER STUDY
Mark J Peters, Padmanabhan Ramnarayan, Barnaby R Scholefield, Lyvonne N Tume, Robert C Tasker
Over the past two decades, pediatric intensive care research networks have been formed across North America, Europe, Asia, and Australia/New Zealand. The U.K. Paediatric Critical Care Society Study Group (PCCS-SG) has over a 20-year tradition of fostering collaborative research, leading to the design and successful conduct of randomized clinical trials (RCTs). To date, the PCCS-SG network has delivered 13 different multicenter RCTs, covering a spectrum of study designs, methodologies, and scale. Lessons from the early years have led PCCS-SG to now focus on the entire process needed for developing an RCT, starting from robust preparatory steps such as surveys, data analysis, and feasibility work through to a definitive RCT...
December 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36331208/evolution-of-the-collaborative-pediatric-critical-care-research-network
#27
JOURNAL ARTICLE
J Michael Dean
The Collaborative Pediatric Critical Care Research Network (CPCCRN) was established by the Eunice Kennedy Shriver National Institute of Child Health and Human Development in May 2005 to develop an infrastructure for collaborative clinical trials and meaningful descriptive studies in pediatric critical care. This article describes the history of CPCCRN, discusses its financial and organizational structure, illustrates how funds were efficiently used to carry out studies, and describes CPCCRN public use datasets and future directions, concluding with the development of the PeRsonalizEd Immunomodulation in PediatriC SepsIS-InducEd MODS study...
November 4, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36316971/demonstration-project-transitioning-a-research-network-to-new-single-irb-platforms
#28
MULTICENTER STUDY
Jeri S Burr, Ann Johnson, Annie Risenmay, Stephanie Bisping, Emily S Serdoz, Whit Coleman, Katherine A Sward, Erin Rothwell, J Michael Dean
Since the 2016 National Institutes of Health (NIH) mandate to use a single IRB (sIRB) in multicenter research, institutions have struggled to operationalize the process. In this demonstration project, the University of Utah Trial Innovation Center assisted the Collaborative Pediatric Critical Care Research Network to transition from using individually negotiated reliance agreements and paper-based documentation to a new sIRB master agreement and an informatics platform to capture reliance documentation. Lessons learned that can guide other academic institutions and IRBs as they operationalize sIRBs included the need for sites to understand what type of engagement or reliance is required and their need to understand the difference between reliance and activation...
November 2022: Ethics & Human Research
https://read.qxmd.com/read/36310809/which-pharmacists-are-performing-antimicrobial-stewardship-a-national-survey-and-a-call-for-collaborative-efforts
#29
JOURNAL ARTICLE
Brandon Dionne, Jamie L Wagner, Daniel B Chastain, Meagen Rosenthal, Monica V Mahoney, Christopher M Bland
Objectives: To determine how pharmacists with formal antimicrobial stewardship program (ASP) responsibilities prioritize their time and pharmacists without formal antimicrobial stewardship program responsibilities contribute to ASP activities. Design: A nationwide survey. Respondents: Members of the American College of Clinical Pharmacy who subscribe to the following practice and research network e-mail listservs: infectious diseases, adult medicine, cardiology, critical care, hematology-oncology, immunology and transplantation, and pediatrics...
2022: Antimicrob Steward Healthc Epidemiol
https://read.qxmd.com/read/36226360/standardizing-electronic-health-record-ventilation-data-in-the-pediatric-long-term-mechanical-ventilator-dependent-population
#30
JOURNAL ARTICLE
Lara J Kanbar, Judith W Dexheimer, Janet Zahner, Evanette K Burrows, Robert Chatburn, Amanda Messinger, Christopher D Baker, Christine L Schuler, Dan Benscoter, Raouf Amin, Nathan Pajor
BACKGROUND: Sharing data across institutions is critical to improving care for children who are using long term mechanical ventilation (LTMV). Mechanical ventilation data are complex and poorly standardized. This lack of data standardization is a major barrier to data sharing. OBJECTIVE: We aimed to describe current ventilator data in the electronic health record (EHR) and propose a framework for standardizing these data using a Common Data Model (CDM) across multiple populations and sites...
October 13, 2022: Pediatric Pulmonology
https://read.qxmd.com/read/36178701/mortality-risk-in-pediatric-sepsis-based-on-c-reactive-protein-and-ferritin-levels
#31
JOURNAL ARTICLE
Christopher M Horvat, Anthony Fabio, Daniel S Nagin, Russell K Banks, Yidi Qin, Hyun-Jung Park, Kate F Kernan, Scott W Canna, Robert A Berg, David Wessel, Murray M Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E Harrison, Athena F Zuppa, Ron W Reeder, Kathy Sward, Richard Holubkov, Daniel A Notterman, J Michael Dean, Joseph A Carcillo
OBJECTIVES: Interest in using bedside C-reactive protein (CRP) and ferritin levels to identify patients with hyperinflammatory sepsis who might benefit from anti-inflammatory therapies has piqued with the COVID-19 pandemic experience. Our first objective was to identify patterns in CRP and ferritin trajectory among critically ill pediatric sepsis patients. We then examined the association between these different groups of patients in their inflammatory cytokine responses, systemic inflammation, and mortality risks...
December 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/36178697/consensus-based-recommendations-on-priority-activities-to-address-acute-kidney-injury-in-children-a-modified-delphi-consensus-statement
#32
JOURNAL ARTICLE
Stuart L Goldstein, Ayse Akcan-Arikan, Rashid Alobaidi, David J Askenazi, Sean M Bagshaw, Matthew Barhight, Erin Barreto, Benan Bayrakci, Orville N R Bignall, Erica Bjornstad, Patrick D Brophy, Rahul Chanchlani, Jennifer R Charlton, Andrea L Conroy, Akash Deep, Prasad Devarajan, Kristin Dolan, Dana Y Fuhrman, Katja M Gist, Stephen M Gorga, Jason H Greenberg, Denise Hasson, Emma Heydari Ulrich, Arpana Iyengar, Jennifer G Jetton, Catherine Krawczeski, Leslie Meigs, Shina Menon, Jolyn Morgan, Catherine J Morgan, Theresa Mottes, Tara M Neumayr, Zaccaria Ricci, David Selewski, Danielle E Soranno, Michelle Starr, Natalja L Stanski, Scott M Sutherland, Jordan Symons, Marcelo S Tavares, Molly Wong Vega, Michael Zappitelli, Claudio Ronco, Ravindra L Mehta, John Kellum, Marlies Ostermann, Rajit K Basu
IMPORTANCE: Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansion of pediatric AKI knowledge. OBJECTIVE: To develop expert-driven pediatric specific recommendations on needed AKI research, education, practice, and advocacy. EVIDENCE REVIEW: At the 26th Acute Disease Quality Initiative meeting conducted in November 2021 by 47 multiprofessional international experts in general pediatrics, nephrology, and critical care, the panel focused on 6 areas: (1) epidemiology; (2) diagnostics; (3) fluid overload; (4) kidney support therapies; (5) biology, pharmacology, and nutrition; and (6) education and advocacy...
September 1, 2022: JAMA Network Open
https://read.qxmd.com/read/36040097/a-core-outcome-measurement-set-for-pediatric-critical-care
#33
JOURNAL ARTICLE
Neethi P Pinto, Aline B Maddux, Leslie A Dervan, Alan G Woodruff, Jessica M Jarvis, Sholeen Nett, Elizabeth Y Killien, Robert J Graham, Karen Choong, Peter M Luckett, Julia A Heneghan, Katherine Biagas, Erin F Carlton, Mary E Hartman, Lauren Yagiela, Kelly N Michelson, Joseph C Manning, Debbie A Long, Jan Hau Lee, Beth S Slomine, Sue R Beers, Trevor Hall, Brenda M Morrow, Kathleen Meert, Maria Del Pilar Arias Lopez, Hennie Knoester, Amy Houtrow, Lenora Olson, Lisa Steele, Luregn J Schlapbach, Randall S Burd, Ruth Grosskreuz, Warwick Butt, Ericka L Fink, R Scott Watson
OBJECTIVES: To identify a PICU Core Outcome Measurement Set (PICU COMS), a set of measures that can be used to evaluate the PICU Core Outcome Set (PICU COS) domains in PICU patients and their families. DESIGN: A modified Delphi consensus process. SETTING: Four webinars attended by PICU physicians and nurses, pediatric surgeons, rehabilitation physicians, and scientists with expertise in PICU clinical care or research ( n = 35). Attendees were from eight countries and convened from the Pediatric Acute Lung Injury and Sepsis Investigators Pediatric Outcomes STudies after PICU Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network PICU COS Investigators...
November 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/35880872/sodium-bicarbonate-use-during-pediatric-cardiopulmonary-resuscitation-a-secondary-analysis-of-the-icu-resuscitation-project-trial
#34
RANDOMIZED CONTROLLED TRIAL
Katherine Cashen, Ron W Reeder, Tageldin Ahmed, Michael J Bell, Robert A Berg, Candice Burns, Joseph A Carcillo, Todd C Carpenter, J Michael Dean, J Wesley Diddle, Myke Federman, Ericka L Fink, Aisha H Frazier, Stuart H Friess, Kathryn Graham, Mark Hall, David A Hehir, Christopher M Horvat, Leanna L Huard, Tensing Maa, Arushi Manga, Patrick S McQuillen, Ryan W Morgan, Peter M Mourani, Vinay M Nadkarni, Maryam Y Naim, Daniel Notterman, Chella A Palmer, Murray M Pollack, Carleen Schneiter, Matthew P Sharron, Neeraj Srivastava, David Wessel, Heather A Wolfe, Andrew R Yates, Athena F Zuppa, Robert M Sutton, Kathleen L Meert
OBJECTIVES: To evaluate associations between sodium bicarbonate use and outcomes during pediatric in-hospital cardiac arrest (p-IHCA). DESIGN: Prespecified secondary analysis of a prospective, multicenter cluster randomized interventional trial. SETTING: Eighteen participating ICUs of the ICU-RESUScitation Project (NCT02837497). PATIENTS: Children less than or equal to 18 years old and greater than or equal to 37 weeks post conceptual age who received chest compressions of any duration from October 2016 to March 2021...
October 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/35871909/research-developments-in-pediatric-intensive-care-nutrition-a-research-intelligence-review
#35
REVIEW
R Iping, J M Hulst, K F M Joosten
BACKGROUND & AIMS: Pediatric intensive care nutrition is a growing research field on the intersection of three large research domains: Pediatrics, Critical Care Medicine and Nutrition & Dietetics. This study, using Research Intelligence tools, such as bibliometric network visualization software, was designed to map the developments in research topics and collaboration in the field over the past thirty years, and discuss how these developments align with recent recommendations and guidelines of the active expert groups in the field...
August 2022: Clinical Nutrition ESPEN
https://read.qxmd.com/read/35834674/pediatric-critical-care-nursing-research-priorities-in-asia-an-edelphi-study
#36
JOURNAL ARTICLE
Pei-Fen Poh, Qian Wen Sng, Jos M Latour, Linxi He, Mei Fung Fong, Jayashree Muralidharah, Qalab Abbas, Yujiro Matsuishi, Jan Hau Lee
OBJECTIVES: To identify nursing research priorities in pediatric critical care in Asia. DESIGN: We conducted a modified three-round eDelphi survey with pediatric critical care nurses in Asia. The eDelphi technique has been extensively used within health research to achieve a common viewpoint from experts using questionnaires to gather research priorities. In round 1, participants were asked to list three to five research topics that they deemed important. These topics were thematically analyzed and categorized into a questionnaire...
July 15, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/35680434/post-discharge-rehabilitation-and-functional-recovery-after-pediatric-injury
#37
JOURNAL ARTICLE
Aline B Maddux, John M VanBuren, Aaron R Jensen, Richard Holubkov, Jessica S Alvey, Patrick McQuillen, Peter M Mourani, Kathleen L Meert, Randall S Burd
INTRODUCTION: Variability in rehabilitation disposition has been proposed as a trauma center quality metric. Benchmarking rehabilitation disposition is limited by a lack of objective measures of functional impairment at discharge. The primary aim of this study was to determine the relative contribution of patient characteristics and hospitalization factors associated with inpatient and outpatient rehabilitation after discharge. The secondary aims were to evaluate the sensitivity of the Functional Status Scale (FSS) score for identifying functional impairments at hospital discharge and track post-discharge recovery...
August 2022: Injury
https://read.qxmd.com/read/35603750/measuring-social-health-following-pediatric-critical-illness-a-scoping-review-and-conceptual-framework
#38
JOURNAL ARTICLE
Hannah Daughtrey, Katherine N Slain, Sabrina Derrington, Idris V R Evans, Denise M Goodman, LeeAnn M Christie, Simon Li, John C Lin, Debbie A Long, Maureen A Madden, Sara VandenBranden, McKenna Smith, Neethi P Pinto, Aline B Maddux, Ericka L Fink, R Scott Watson, Leslie A Dervan
OBJECTIVE: Social health is an important component of recovery following critical illness as modeled in the pediatric Post-Intensive Care Syndrome framework. We conducted a scoping review of studies measuring social outcomes (measurable components of social health) following pediatric critical illness and propose a conceptual framework of the social outcomes measured in these studies. DATA SOURCES: PubMed, EMBASE, PsycINFO, CINAHL, and the Cochrane Registry. STUDY SELECTION: We identified studies evaluating social outcomes in pediatric intensive care unit (PICU) survivors or their families from 1970-2017 as part of a broader scoping review of outcomes after pediatric critical illness...
May 22, 2022: Journal of Intensive Care Medicine
https://read.qxmd.com/read/35452018/assessment-of-patient-health-related-quality-of-life-and-functional-outcomes-in-pediatric-acute-respiratory-distress-syndrome
#39
JOURNAL ARTICLE
Stefanie G Ames, Russell K Banks, Matt S Zinter, Ericka L Fink, Patrick S McQuillen, Mark W Hall, Athena Zuppa, Kathleen L Meert, Peter M Mourani, Joseph A Carcillo, Todd Carpenter, Murray M Pollack, Robert A Berg, Manvita Mareboina, Richard Holubkov, J Michael Dean, Daniel A Notterman, Anil Sapru
OBJECTIVES: To describe health-related quality of life (HRQL) and functional outcomes in pediatric acute respiratory distress syndrome (ARDS) and to determine risk factors associated with poor outcome defined as death or severe reduction in HRQL at 28 days or ICU discharge. DESIGN: Prospective multisite cohort-outcome study conducted between 2019 and 2020. SETTING: Eight academic PICUs in the United States. PATIENTS: Children with ARDS based on standard criteria...
April 22, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/35357723/quality-improvement-in-new-zealand-pediatric-anesthesia-national-quality-direction-patient-experience-equity-and-collaboration
#40
REVIEW
Elsa Taylor, Craig S Webster
The current priorities of the quality and safety of patient care in New Zealand at a central government level are described, with a focus on equity and patient experience. Priorities between stakeholders differ. We report the current quality activities of New Zealand pediatric anesthetists in relation to these governance aims, seeking gaps and suggesting future directions to align governance priorities and local activities. International relevance is also outlined. New Zealand Māori experience health inequity...
November 2022: Paediatric Anaesthesia
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