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Collaborative Pediatric Critical Care Research Network

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https://www.readbyqxmd.com/read/27753764/inherent-risk-factors-for-nosocomial-infection-in-the-long-stay-critically-ill-child-without-known-baseline-immunocompromise-a-post-hoc-analysis-of-the-crisis-trial
#1
Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kanwaljeet J S Anand, Jerry Zimmerman, Christopher J Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster
BACKGROUND: Nosocomial infection remains an important health problem in long stay (>3 days) pediatric intensive care unit (PICU) patients. Admission risk factors related to the development of nosocomial infection in long stay immune competent patients in particular are not known. METHODS: Post-hoc analysis of the previously published Critical Illness Stress induced Immune Suppression (CRISIS) prevention trial database, to identify baseline risk factors for nosocomial infection...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27679964/strategic-planning-for-research-in-pediatric-critical-care
#2
Robert F Tamburro, Tammara L Jenkins, Patrick M Kochanek
OBJECTIVE: To summarize the scientific priorities and potential future research directions for pediatric critical care research discussed by a panel of experts at the inaugural Strategic Planning Conference of the Pediatric Trauma and Critical Illness Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. DATA SOURCES: Expert opinion expressed during the Strategic Planning Conference. STUDY SELECTION: Not applicable...
November 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27662565/short-term-health-related-quality-of-life-of-critically-ill-children-following-daily-sedation-interruption
#3
Nienke J Vet, Saskia N de Wildt, Carin W M Verlaat, Miriam G Mooij, Dick Tibboel, Matthijs de Hoog, Corinne M P Buysse
OBJECTIVE: Our earlier pediatric daily sedation interruption trial showed that daily sedation interruption in addition to protocolized sedation in critically ill children does not reduce duration of mechanical ventilation, length of stay, or amounts of sedative drugs administered when compared with protocolized sedation only, but undersedation was more frequent in the daily sedation interruption + protocolized sedation group. We now report the preplanned analysis comparing short-term health-related quality of life and posttraumatic stress symptoms between the two groups...
November 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27660289/interaction-between-2-nutraceutical-treatments-and-host-immune-status-in-the-pediatric-critical-illness-stress-induced-immune-suppression-comparative-effectiveness-trial
#4
Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kanwaljeet J S Anand, Jerry J Zimmerman, Christopher J L Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster, Robert F Tamburro
BACKGROUND AND AIMS: The pediatric Critical Illness Stress-induced Immune Suppression (CRISIS) trial compared the effectiveness of 2 nutraceutical supplementation strategies and found no difference in the development of nosocomial infection and sepsis in the overall population. We performed an exploratory post hoc analysis of interaction between nutraceutical treatments and host immune status related to the development of nosocomial infection/sepsis. METHODS: Children from the CRISIS trial were analyzed according to 3 admission immune status categories marked by decreasing immune competence: immune competent without lymphopenia, immune competent with lymphopenia, and previously immunocompromised...
September 22, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27595356/collaboration-and-networking
#5
O Husson, E Manten-Horst, W T A van der Graaf
Awareness of the need for collaboration across pediatric and adult cancer to care for adolescents and young adults (AYAs) arose from the recognition of the unique characteristics of AYAs with cancer. Neither pediatric nor adult oncology hospital departments are able to provide age-appropriate care single handedly. The best way to bridge the gap in care of AYA cancer patients is to centralize aspects of their care within dedicated AYA care programs, including the following essential components: provision of developmentally appropriate and multidisciplinary (supportive) care, availability of AYA inpatient and outpatient facilities and healthcare professional AYA expertise as collaboration between adult and pediatric departments...
2016: Progress in Tumor Research
https://www.readbyqxmd.com/read/27379619/inherent-risk-factors-for-nosocomial-infection-in-the-long-stay-critically-ill-child-without-known-baseline-immunocompromise-a-post-hoc-analysis-of-the-crisis-trial
#6
Joseph A Carcillo, J Michael Dean, Richard Holubkov, John Berger, Kathleen L Meert, Kjs Anand, Jerry Zimmerman, Christopher J Newth, Rick Harrison, Jeri Burr, Douglas F Willson, Carol Nicholson, Michael J Bell, Robert A Berg, Thomas P Shanley, Sabrina M Heidemann, Heidi Dalton, Tammara L Jenkins, Allan Doctor, Angie Webster
BACKGROUND: Nosocomial infection remains an important health problem in long stay (> 3 days) pediatric intensive care unit (PICU) patients. Admission risk factors related to the development of nosocomial infection in long stay immune competent patients in particular are not known. METHODS: Post-hoc analysis of the previously published Critical Illness Stress induced Immune Suppression (CRISIS) prevention trial database, to identify baseline risk factors for nosocomial infection...
June 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27351267/the-impact-of-clinical-trials-conducted-by-research-networks-in-pediatric-critical-care
#7
Karen Choong, Mark Duffett, Deborah J Cook, Adrienne G Randolph
OBJECTIVES: Research networks in adult and neonatal critical care have demonstrated collaborative and successful execution of clinical trials. Such networks appear to have been relatively recently established in the field of pediatric critical care. The objective of this study was to evaluate the productivity and impact of randomized controlled trials conducted by pediatric critical care research networks, compared with nonnetwork trials. DATA SOURCES, STUDY SELECTION, AND DATA ABSTRACTION: We searched multiple online databases including MEDLINE, reference lists of randomized controlled trials, and relevant systematic reviews...
September 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26958992/case-study-semantic-annotation-of-a-pediatric-critical-care-research-study
#8
Katherine A Sward, Sarah Rubin, Tammara L Jenkins, Christopher J Newth, J Michael Dean
No abstract text is available yet for this article.
March 2016: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/26890200/diagnosis-and-treatment-of-ventilator-associated-infection-review-of-the-critical-illness-stress-induced-immune-suppression-prevention-trial-data
#9
Douglas F Willson, Angela Webster, Sabrina Heidemann, Kathleen L Meert
OBJECTIVES: The Critical Illness Stress-Induced Immune Suppression prevention trial was a randomized, masked trial of zinc, selenium, glutamine, and metoclopramide compared with whey protein in delaying nosocomial infection in PICU patients. One fourth of study subjects were diagnosed with nosocomial lower respiratory infection, which contributed to subjects receiving antibiotics 74% of all patient days in the PICU. We analyzed diagnostic and treatment variability among the participating institutions and compared outcomes between nosocomial lower respiratory infection subjects (n = 74) and intubated subjects without nosocomial infection (n = 1 55)...
April 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26646466/incidence-and-outcomes-of-cardiopulmonary-resuscitation-in-picus
#10
Robert A Berg, Vinay M Nadkarni, Amy E Clark, Frank Moler, Kathleen Meert, Rick E Harrison, Christopher J L Newth, Robert M Sutton, David L Wessel, John T Berger, Joseph Carcillo, Heidi Dalton, Sabrina Heidemann, Thomas P Shanley, Athena F Zuppa, Allan Doctor, Robert F Tamburro, Tammara L Jenkins, J Michael Dean, Richard Holubkov, Murray M Pollack
OBJECTIVES: To determine the incidence of cardiopulmonary resuscitation in PICUs and subsequent outcomes. DESIGN, SETTING, AND PATIENTS: Multicenter prospective observational study of children younger than 18 years old randomly selected and intensively followed from PICU admission to hospital discharge in the Collaborative Pediatric Critical Care Research Network December 2011 to April 2013. RESULTS: Among 10,078 children enrolled, 139 (1...
April 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26513203/research-as-a-standard-of-care-in-the-picu
#11
REVIEW
Jerry J Zimmerman, Kanwaljeet J S Anand, Kathleen L Meert, Douglas F Willson, Christopher J L Newth, Rick Harrison, Joseph A Carcillo, John Berger, Tammara L Jenkins, Carol Nicholson, J Michael Dean
OBJECTIVES: Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. PICUs are uniquely suited for conducting translational and clinical research. In addition, multiple investigations have reported that a majority of parents are interested in their children's participation in clinical research, even when the research offers no direct benefit to their child...
January 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26492059/the-pediatric-risk-of-mortality-score-update-2015
#12
Murray M Pollack, Richard Holubkov, Tomohiko Funai, J Michael Dean, John T Berger, David L Wessel, Kathleen Meert, Robert A Berg, Christopher J L Newth, Rick E Harrison, Joseph Carcillo, Heidi Dalton, Thomas Shanley, Tammara L Jenkins, Robert Tamburro
OBJECTIVES: Severity of illness measures have long been used in pediatric critical care. The Pediatric Risk of Mortality is a physiologically based score used to quantify physiologic status, and when combined with other independent variables, it can compute expected mortality risk and expected morbidity risk. Although the physiologic ranges for the Pediatric Risk of Mortality variables have not changed, recent Pediatric Risk of Mortality data collection improvements have been made to adapt to new practice patterns, minimize bias, and reduce potential sources of error...
January 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/26335128/end-of-life-practices-among-tertiary-care-picus-in-the-united-states-a-multicenter-study
#13
MULTICENTER STUDY
Kathleen L Meert, Linda Keele, Wynne Morrison, Robert A Berg, Heidi Dalton, Christopher J L Newth, Rick Harrison, David L Wessel, Thomas Shanley, Joseph Carcillo, Amy Clark, Richard Holubkov, Tammara L Jenkins, Allan Doctor, J Michael Dean, Murray Pollack
OBJECTIVE: To describe variability in end-of-life practices among tertiary care PICUs in the United States. DESIGN: Secondary analysis of data prospectively collected from a random sample of patients (n = 10,078) admitted to PICUs affiliated with the Collaborative Pediatric Critical Care Research Network between December 4, 2011, and April 7, 2013. SETTING: Seven clinical centers affiliated with the Collaborative Pediatric Critical Care Research Network...
September 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25985385/simultaneous-prediction-of-new-morbidity-mortality-and-survival-without-new-morbidity-from-pediatric-intensive-care-a-new-paradigm-for-outcomes-assessment
#14
MULTICENTER STUDY
Murray M Pollack, Richard Holubkov, Tomohiko Funai, John T Berger, Amy E Clark, Kathleen Meert, Robert A Berg, Joseph Carcillo, David L Wessel, Frank Moler, Heidi Dalton, Christopher J L Newth, Thomas Shanley, Rick E Harrison, Allan Doctor, Tammara L Jenkins, Robert Tamburro, J Michael Dean
OBJECTIVES: Assessments of care including quality assessments adjusted for physiological status should include the development of new morbidities as well as mortalities. We hypothesized that morbidity, like mortality, is associated with physiological dysfunction and could be predicted simultaneously with mortality. DESIGN: Prospective cohort study from December 4, 2011, to April 7, 2013. SETTING: General and cardiac/cardiovascular PICUs at seven sites...
August 2015: Critical Care Medicine
https://www.readbyqxmd.com/read/25796596/virtualization-of-open-source-secure-web-services-to-support-data-exchange-in-a-pediatric-critical-care-research-network
#15
Lewis J Frey, Katherine A Sward, Christopher J L Newth, Robinder G Khemani, Martin E Cryer, Julie L Thelen, Rene Enriquez, Su Shaoyu, Murray M Pollack, Rick E Harrison, Kathleen L Meert, Robert A Berg, David L Wessel, Thomas P Shanley, Heidi Dalton, Joseph Carcillo, Tammara L Jenkins, J Michael Dean
OBJECTIVES: To examine the feasibility of deploying a virtual web service for sharing data within a research network, and to evaluate the impact on data consistency and quality. MATERIAL AND METHODS: Virtual machines (VMs) encapsulated an open-source, semantically and syntactically interoperable secure web service infrastructure along with a shadow database. The VMs were deployed to 8 Collaborative Pediatric Critical Care Research Network Clinical Centers. RESULTS: Virtual web services could be deployed in hours...
November 2015: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/25647124/association-of-bleeding-and-thrombosis-with-outcome-in-extracorporeal-life-support
#16
MULTICENTER STUDY
Heidi J Dalton, Pamela Garcia-Filion, Richard Holubkov, Frank W Moler, Thomas Shanley, Sabrina Heidemann, Kathleen Meert, Robert A Berg, John Berger, Joseph Carcillo, Christopher Newth, Richard Harrison, Allan Doctor, Peter Rycus, J Michael Dean, Tammara Jenkins, Carol Nicholson
OBJECTIVE: Changes in technology and increased reports of successful extracorporeal life support use in patient populations, such as influenza, cardiac arrest, and adults, are leading to expansion of extracorporeal life support. Major limitations to extracorporeal life support expansion remain bleeding and thrombosis. These complications are the most frequent causes of death and morbidity. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network...
February 2015: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25226501/pediatric-intensive-care-outcomes-development-of-new-morbidities-during-pediatric-critical-care
#17
Murray M Pollack, Richard Holubkov, Tomohiko Funai, Amy Clark, John T Berger, Kathleen Meert, Christopher J L Newth, Thomas Shanley, Frank Moler, Joseph Carcillo, Robert A Berg, Heidi Dalton, David L Wessel, Rick E Harrison, Allan Doctor, J Michael Dean, Tammara L Jenkins
OBJECTIVE: To investigate significant new morbidities associated with pediatric critical care. DESIGN: Randomly selected, prospective cohort. SETTING: PICU patients from eight medical and cardiac PICUs. PATIENTS: This was a randomly selected, prospective cohort of PICU patients from eight medical and cardiac PICUs. MEASUREMENTS AND MAIN RESULTS: The main outcomes measures were hospital discharge functional status measured by Functional Status Scale scores and new morbidity defined as an increase in the Functional Status Scale of more than or equal to 3...
November 2014: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/25055195/a-single-nucleotide-polymorphism-in-the-corticotropin-receptor-gene-is-associated-with-a-blunted-cortisol-response-during-pediatric-critical-illness
#18
David Jardine, Mary Emond, Kathleen L Meert, Rick Harrison, Joseph A Carcillo, Kanwaljeet J S Anand, John Berger, Christopher J L Newth, Douglas F Willson, Carol Nicholson, J Michael Dean, Jerry J Zimmerman
OBJECTIVES: The cortisol response during critical illness varies widely among patients. Our objective was to examine single nucleotide polymorphisms in candidate genes regulating cortisol synthesis, metabolism, and activity to determine if genetic differences were associated with variability in the cortisol response among critically ill children. DESIGN: This was a prospective observational study employing tag single nucleotide polymorphism methodology to examine genetic contributions to the variability of the cortisol response in critical illness...
October 2014: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/24862461/relationship-between-the-functional-status-scale-and-the-pediatric-overall-performance-category-and-pediatric-cerebral-performance-category-scales
#19
MULTICENTER STUDY
Murray M Pollack, Richard Holubkov, Tomohiko Funai, Amy Clark, Frank Moler, Thomas Shanley, Kathy Meert, Christopher J L Newth, Joseph Carcillo, John T Berger, Allan Doctor, Robert A Berg, Heidi Dalton, David L Wessel, Rick E Harrison, J Michael Dean, Tammara L Jenkins
IMPORTANCE: Functional status assessment methods are important as outcome measures for pediatric critical care studies. OBJECTIVE: To investigate the relationships between the 2 functional status assessment methods appropriate for large-sample studies, the Functional Status Scale (FSS) and the Pediatric Overall Performance Category and Pediatric Cerebral Performance Category (POPC/PCPC) scales. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study with random patient selection at 7 sites and 8 children's hospitals with general/medical and cardiac/cardiovascular pediatric intensive care units (PICUs) in the Collaborative Pediatric Critical Care Research Network...
July 2014: JAMA Pediatrics
https://www.readbyqxmd.com/read/24524204/daily-interruption-of-sedation-in-critically-ill-children-study-protocol-for-a-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Nienke J Vet, Saskia N de Wildt, Carin W M Verlaat, Catherijne A J Knibbe, Miriam G Mooij, Wim C J Hop, Joost van Rosmalen, Dick Tibboel, Matthijs de Hoog
BACKGROUND: In adult patients who are critically ill and mechanically ventilated, daily interruption of sedation (DSI) is an effective method of improving sedation management, resulting in a decrease of the duration of mechanical ventilation, the length of stay in the intensive care unit (ICU) and the length of stay in the hospital. It is a safe and effective approach and is common practice in adult ICUs. For critically ill children it is unknown if DSI is effective and feasible. The aim of this multicenter randomized controlled trial is to evaluate the safety and efficacy of daily sedation interruption in critically ill children...
2014: Trials
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