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Gary F Scott, Anh Q Nguyen, Brandon H Cherry, Roger A Hollrah, Isabella Salinas, Arthur G Williams, Myoung-Gwi Ryou, Robert T Mallet
Cardiac arrest (CA) and cardiocerebral resuscitation (CCR)-induced ischemia-reperfusion imposes oxidative and carbonyl stress that injures the brain. The ischemic shift to anaerobic glycolysis, combined with oxyradical inactivation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), provokes excessive formation of the powerful glycating agent, methylglyoxal. The glyoxalase (GLO) system, comprising the enzymes glyoxalase 1 (GLO1) and GLO2, utilizes reduced glutathione (GSH) supplied by glutathione reductase (GR) to detoxify methylglyoxal resulting in reduced protein glycation...
January 1, 2017: Experimental Biology and Medicine
Shuang Li, Wenwu Cai, Xin Li, Jian Qiu, Quanming Li, Chang Shu
BACKGROUND: to share our experience and demonstrate the feasibility, safety and efficacy of Thoracic endovascular aortic repair (TEVAR) for traumatic Type B Aortic Dissection (TTBAD). METHODS: Between October 2010 and October 2015, 36 patients, who have been diagnosed as TTBAD, were included. A computed tomography angiography (CTA) scan was performed to confirm the diagnosis and to localize the aortic entry. The clinical data and outcomes of these patients were retrospectively reviewed and collected for further analysis...
March 14, 2017: International Angiology: a Journal of the International Union of Angiology
Xin Lan, Hongqing Xi, Kecheng Zhang, Jianxin Cui, Mingsen Li, Lin Chen
OBJECTIVE: To compare clinically relevant postoperative complications after open, laparoscopic, and robotic gastrectomy for gastric cancer. METHODS: Clinical data of patients with gastric cancer who underwent gastrectomy between January 1, 2014 and October 1, 2016 at Chinese People's Liberation Army General Hospital were analyzed retrospectively. All the patients were diagnosed by upper endoscopy and confirmed by biopsy without distant metastasis. They were confirmed with R0 resection by postoperative pathology...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Hongru Fan, Jihong Yang, Lili Liu, Yu Qiao, Meng Wang, Lei Qiu, Hong Shi, Huan Xi, Yao Wang
OBJECTIVE: To investigate the influence of serum albumin on the prognosis of elderly patients with stage 3-4 chronic kidney disease (CKD). METHODS: From July 2013 to November 2015, elderly CKD patients (≥60 years), with eGFR ≥15 mL/min/1.73 m(2) and <60 mL/min/1.73 m(2), with CKD stage 3-4 in the geriatric nephrology clinic were enrolled. General information and underlying diseases were recorded. Laboratory indices were evaluated. Composite endpoint events (CEE) including renal endpoint events, cardiocerebral vascular endpoint events, and death were elucidated...
February 21, 2017: International Urology and Nephrology
Leonard L L Yeo, Tommy Andersson, Kong Wan Yee, Benjamin Y Q Tan, Prakash Paliwal, Anil Gopinathan, Mahendran Nadarajah, Eric Ting, Hock L Teoh, Robin Cherian, Erik Lundström, Edgar L W Tay, Vijay K Sharma
A cardiocerebral ischemic attack (CCI) or a concurrent acute ischemic stroke (AIS) and myocardial infarction (AMI) is a severe event with no clear recommendations for ideal management because of the rarity of the scenario. The narrow time window for treatment and complexity of the treatment decision puts immense pressure on the treating physician. We evaluated this challenging situation at our tertiary center. Using our prospective stroke database out of a total of 555 patients with acute ischemic stroke between 2009 and 2014, we identified five consecutive cases with CCI (incidence 0...
February 20, 2017: Journal of Thrombosis and Thrombolysis
Christian D Erkelens, Haye H van der Wal, Bauke M de Jong, Jan-Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M van Deursen, Peter van der Meer, Dirk J van Veldhuisen, Adriaan A Voors, Gert-Jan Luijckx
AIMS: Heart failure (HF) is associated with tissue hypoperfusion and congestion leading to organ dysfunction. Although cerebral blood flow (CBF) is preserved over a wide range of perfusion pressures in healthy subjects, it is impaired in end-stage HF. We aimed to compare CBF, autoregulation, and cognitive function in patients with mild non-ischaemic HF with healthy controls. METHODS AND RESULTS: Fifteen patients with mild idiopathic dilated cardiomyopathy and 15 matched healthy controls were studied...
November 14, 2016: European Journal of Heart Failure
Aya G Elmarsafawi, Maggie M Abbassi, Sameh Elkaffas, Hassan M Elsawy, Nirmeen A Sabry
OBJECTIVES: Comparing different perioperative statin regimens for the prevention of post-coronary artery bypass grafting adverse events. DESIGN: A randomized, prospective study. SETTING: Cardiothoracic surgical units in a government hospital. PARTICIPANTS: The study comprised 94 patients scheduled for elective, isolated on- or off- pump coronary artery bypass grafting. INTERVENTIONS: Patients were assigned randomly to 1 of the following 3 treatment groups: group I (80 mg of atorvastatin/day for 2 days preoperatively), group II (40 mg of atorvastatin/day for 5-9 days preoperatively), or group III (80 mg of atorvastatin/day for 5-9 days preoperatively)...
December 2016: Journal of Cardiothoracic and Vascular Anesthesia
Claudia A Perez, Niyatee Samudra, Venkatesh Aiyagari
Cardiac arrest is associated with high morbidity and mortality. Better-quality bystander cardiopulmonary resuscitation training, cardiocerebral resuscitation principles, and intensive post-resuscitation hospital care have improved survival. However, cognitive and functional impairment after cardiac arrest remain areas of concern. Research focus has shifted beyond prognostication in the immediate post-arrest period to identification of mechanisms for long-term brain injury and implementation of promising protocols to reduce neuronal injury...
August 2016: Current Neurology and Neuroscience Reports
Yu Pan, Qi Qiu, Fang Chen, Xuelian Li, Xianpeng Yu, Yawei Luo, Quan Li, Jiqiang He, Yuechun Gao, Xiaoling Zhang, Xuejun Ren
OBJECTIVES: This study aimed to evaluate clinical outcomes after percutaneous coronary intervention with drug-eluting stents (DESs) or coronary artery bypass grafting (CABG) in unprotected left main coronary artery (ULMCA) disease patients with and without chronic kidney disease. BACKGROUND: The optimal coronary revascularization strategy for ULMCA disease patients with chronic kidney disease remains uncertain. METHODS: The sample included 818 ULMCA disease patients who received DESs (n=358) or underwent CABG (n=460)...
November 2016: Coronary Artery Disease
Bo-Yu Li, Xiao-Ming Li, Yan Zhang, Zhan-Yun Wei, Jing Li, Qi Hua
OBJECTIVE: To investigate whether coronary artery revascularization therapies (CART), including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), can improve the in-hospital and long-term outcomes for acute myocardial infarction (AMI) patients with prior ischemic stroke (IS). METHODS: A total of 387 AMI patients with prior IS were enrolled consecutively from January 15, 2005 to December 24, 2011 in this cohort study. All patients were categorized into the CART group (n = 204) or the conservative medications (CM) group (n = 183)...
February 2016: Journal of Geriatric Cardiology: JGC
Cong Hui Wang, Li Ping Zheng, Hao Tian, Jian Wen Wang
Tanshinones are major bioactive diterpenoids of Salvia miltiorrhiza roots used for the treatment of cardiocerebral diseases. To develop effective elicitation and bioprocess strategies for the enhanced production of tanshinones, ultraviolet-B (UV-B) irradiation and methyl jasmonate (MeJA) elicitation were applied alone or in combination respectively in S. miltiorrhiza hairy root cultures. Our results showed 40-min UV-B irradiation at 40μW/cm(2) stimulated tanshinone production without any suppression of root growth, suggesting a new effective elicitor to S...
June 2016: Journal of Photochemistry and Photobiology. B, Biology
Yan Wang, Qingchan Yang, Jing Feng, Jie Cao, Baoyuan Chen
BACKGROUND: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common sleep-related breathing disorder. Hypertension is frequently a concomitant disorder in patients with OSAHS. PURPOSE: This study investigates the prevalence and clinical features of hypertension in patients with OSAHS and explores the related nursing strategies. METHODS: Three thousand six hundred seven patients were included in this study. Subjects were divided into four groups that were categorized according to apnea-hypopnea index (AHI) scores as follows: control group (control, n = 354) with AHI < 5, mild OSAHS (mild, n = 658) with 5 ≤ AHI < 15, moderate OSAHS (moderate, n = 753) with 15 ≤ AHI < 30, and severe OSAHS (severe, n = 1842) with AHI ≥ 30...
March 2016: Journal of Nursing Research: JNR
Monica Coll, Catarina Allegue, Sara Partemi, Jesus Mates, Bernat Del Olmo, Oscar Campuzano, Vincenzo Pascali, Anna Iglesias, Pasquale Striano, Antonio Oliva, Ramon Brugada
Sudden unexpected death in epilepsy (SUDEP) is defined as the abrupt, no traumatic, witnessed or unwitnessed death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus (seizure duration ≥ 30 min or seizures without recovery), and in which postmortem examination does not reveal a cause of death. Although the physiopathological mechanisms that underlie SUDEP remain to be clarified, the genetic background has been described to play a role in this disorder...
March 2016: International Journal of Legal Medicine
Robert C Bertheau, Fabian Bamberg, Elena Lochner, Hannes M Findeisen, Klaus G Parhofer, Hans-Ulrich Kauczor, Stefan O Schoenberg, Sabine Weckbach, Christopher L Schlett
OBJECTIVES: Whether whole-body MRI can predict occurrence of recurrent events in patients with diabetes mellitus. METHODS: Whole-body MRI was prospectively applied to 61 diabetics and assessed for arteriosclerosis and ischemic cerebral/myocardial changes. Occurrence of cardiocerebral events and diabetic comorbidites was determined. Patients were stratified whether no, a single or recurrent events arose. As a secondary endpoint, events were stratified into organ system-specific groups...
May 2016: European Radiology
Lizhu Zhao, Wen Qi, Fangfang Chen, Jiahong Sun, Dan Yuan
BACKGROUND AND OBJECTIVE: Isocorynoxeine (IC), a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. Its metabolic pathway, however, has not been well studied yet. In this study, an ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (U-HPLC/Q-TOFMS) method was developed to investigate IC metabolism in plasma, urine and bile in rats given IC orally at 40 mg/kg. METHODS: Nine male Wistar rats were given IC 40 mg/kg orally...
October 2016: European Journal of Drug Metabolism and Pharmacokinetics
Jiapeng Huang, Macarius Donneyong, Jaimin Trivedi, April Barnard, John Chaney, Adam Dotson, Sherri Raymer, Allen Cheng, Hong Liu, Mark S Slaughter
BACKGROUND: Preoperative aspirin use within 5 days of cardiac operations is controversial. Aspirin could reduce cardiovascular complications and yet might increase risk of bleeding. Recent reports showed conflicting results, and whether aspirin has variable effects for different cardiac surgical procedures is unclear. METHODS: A single-center retrospective cohort analysis was performed. After propensity score matching (PSM) for identified confounders, the relationship between preoperative aspirin use and 30-day all-cause mortality, postoperative renal failure, major adverse cardiocerebral events (MACE), blood transfusion, reoperation for bleeding, and postoperative infection were estimated with separate logistic regression models...
June 2015: Annals of Thoracic Surgery
Ya-Jie Zhang, Meng-Jun Wu, Yi Li, Hai Yu
Although improvement in cardiopulmonary resuscitation (CPR) performance and the increasing success at achieving return of spontaneous circulation (ROSC) have been possible in recent years, the survival and discharge rates of post-cardiac arrest (CA) patients remain disappointing. The high mortality rate is attributed to whole-body ischemia/reperfusion (I/R) induced multi-organ dysfunction that is well known as post-cardiac arrest syndrome. Post-cardiac arrest myocardial dysfunction and brain injury are the main clinical features of this complex pathophysiological process...
January 2015: Medical Hypotheses
Gordon A Ewy, Bentley J Bobrow
Out-of-hospital cardiac arrest (OHCA) is a major public health problem. In the United States, OHCA accounts for more premature deaths than any other cause. For over a half-century, the national "Guidelines" for resuscitation have recommended the same initial treatment of primary and secondary cardiac arrests. Using this approach, the overall survival of patients with OHCA, while quite variable, was generally very poor. One reason is that the etiologies of cardiac arrests are not all the same. The vast majority of nontraumatic OHCA in adults are due to a "primary" cardiac arrest, rather than secondary to respiratory arrest...
January 2016: Journal of Intensive Care Medicine
Fuhai Ji, Zhongmin Li, Nilas Young, Peter Moore, Hong Liu
OBJECTIVE: This study retrospectively investigated the effect of dexmedetomidine on outcomes of patients undergoing coronary artery bypass graft (CABG) surgery. DESIGN: Retrospective investigation. SETTING: Patients from a single tertiary medical center. PARTICIPANTS: A total of 724 patients undergoing CABG surgery met the inclusion criteria and were categorized into 2 groups: 345 in the dexmedetomidine group (DEX) and 379 in the nondexmedetomidine group (Non-DEX)...
April 2014: Journal of Cardiothoracic and Vascular Anesthesia
Gordon A Ewy, Mathias Zuercher
The previously published randomized trials of mechanical versus manual resuscitation of patients with cardiac arrest are inconclusive, but a recent systematic review concluded: "There is no evidence that mechanical cardiopulmonary resuscitation devices improve survival; to the contrary they may worsen neurological outcome." However, in our view, none of the randomized trials to date are definitive as the manual groups with primary cardiac arrest have not been treated optimally; that is, with minimally interrupted manual chest compressions, as advocated with cardiocerebral resuscitation...
November 2013: Future Cardiology
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