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https://www.readbyqxmd.com/read/28723381/efficacy-and-safety-of-onabotulinumtoxina-in-patients-with-urinary-incontinence-due-to-neurogenic-detrusor-overactivity-update-of-the-pivotal-randomised-double-blind-placebo-controlled-trials
#1
Carlos Martins-Silva, Francisco Cruz
Bladder injections of 200U onabotulinumtoxinA have similar efficacy in the treatment of urinary incontinence in patients with multiple sclerosis or spinal cord injury. The effect is maintained in the long term without significant adverse events.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723371/complications-of-transvaginal-mesh-for-pelvic-organ-prolapse-and-stress-urinary-incontinence-tips-for-prevention-recognition-and-management
#2
REVIEW
Susan MacDonald, Ryan Terlecki, Elisabetta Costantini, Gopal Badlani
CONTEXT: Mesh-related complications following transvaginal management of pelvic organ prolapse (POP) and/or stress urinary incontinence (SUI) have received significant attention in the last decade. OBJECTIVE: We sought to identify patient, product, and technical factors associated with an increased risk of complications after mesh-based transvaginal repair of anterior POP and SUI. In this review we clarify the different pattern of complications after POP and SUI repairs...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723369/evaluation-and-classification-of-stress-urinary-incontinence-current-concepts-and-future-directions
#3
REVIEW
Nadir I Osman, Vincenzo Li Marzi, Jean N Cornu, Marcus J Drake
CONTEXT: Stress urinary incontinence (SUI) is a common and bothersome problem that frequently requires operative management. Over the past two decades, novel techniques have been introduced into clinical practice. With the greater variety of surgical options now available, there is an increasing focus on selecting the appropriate procedure for the individual patient based on the likely underlying pathophysiologic mechanism. OBJECTIVE: To review the methods used in the evaluation of SUI and the proposed classification systems...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721482/the-impact-of-urodynamics-on-treatment-and-outcomes-in-women-with-an-overactive-bladder-a-longitudinal-prospective-follow-up-study
#4
Tina Sara Verghese, Lee J Middleton, Jane P Daniels, Jonathan J Deeks, Pallavi Manish Latthe
INTRODUCTION AND HYPOTHESIS: The aim of this study was to establish if the management of women with overactive bladder (OAB) and patient-reported outcomes differed based on the findings of urodynamics (UDS). METHODS: A prospective, longitudinal observational study conducted in urogynaecology clinics in 22 UK hospitals participating in the Diagnostic Accuracy of Bladder Ultrasound Study (BUS). A total of 687 women with OAB symptoms or urgency-predominant mixed urinary incontinence were recruited into a diagnostic study that used UDS as the reference standard...
July 18, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28720359/functional-outcomes-following-radical-cystectomy-in-women-with-bladder-cancer-a-systematic-review
#5
REVIEW
Angela B Smith, Karen Crowell, Michael E Woods, Eric M Wallen, Raj S Pruthi, Matthew E Nielsen, Cheryl T Lee
CONTEXT: Gender-specific functional and health-related quality of life (HRQOL) outcomes following radical cystectomy (RC) for bladder cancer (BCa) remain unclear, with many studies excluding women from the study population. OBJECTIVE: To better characterize female-specific functional outcomes following RC and urinary diversion for BCa. EVIDENCE ACQUISITION: We performed a critical review of PubMed/Medline and Embase in August 2015 according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28718690/predictors-of-short-term-and-long-term-incontinence-after-robot-assisted-radical-prostatectomy
#6
I-Hung Shao, Ying-Hsu Chang, Chun-Ming Hou, Zheng-Feng Lin, Chun-Te Wu
Purpose To determine retrospectively the prognostic factors for urinary incontinence following robot-assisted radical prostatectomy (RARP). Methods Altogether, 180 patients with localized prostate cancer underwent RARP (same surgeon). Preoperative physical status, disease characteristics, laboratory findings, and surgical technique were recorded and the patients checked 1, 6, 12, and 24 months after RARP regarding their contribution to predicting post-prostatectomy urinary incontinence (PPI). Results Overall, 114 (63...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28718163/incidence-and-management-of-lower-urinary-tract-symptoms-after-urethral-stricture-repair
#7
REVIEW
Amanda S J Chung, Kurt A McCammon
Lower urinary tract symptoms (LUTS) after urethral stricture repair are not uncommon. Urgency has been reported in 40% of men and urge incontinence in 12% of men after anterior urethroplasty. De novo urgency and urge incontinence is seen in 9 and 5% of men, respectively, after urethroplasty. Once a complication of urethroplasty (such as recurrent urethral stricture or diverticulum) has been excluded as a cause, evaluation of LUTS in such patients should focus on differentiating bladder dysfunction (overactive bladder, underactive bladder), from other outlet obstruction (such as benign prostatic obstruction), dysfunctional voiding, or medical causes (such as nocturnal polyuria)...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28718161/frailty-and-lower-urinary-tract-symptoms
#8
REVIEW
Anne M Suskind
The incidence of both frailty and lower urinary tract symptoms, including urinary incontinence, overactive bladder, underactive bladder, and benign prostatic hyperplasia, increases with age. However, our understanding of the relationship between frailty and lower urinary tract symptoms, both in terms of pathophysiology and in terms of the evaluation and management of such symptoms, is greatly lacking. This brief review will summarize definitions and measurement tools associated with frailty and will also review the existing state of the literature on frailty and lower urinary tract symptoms in older individuals...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717406/neurogenic-bowel-dysfunction-in-patients-with-neurogenic-bladder
#9
Laura Martinez, Leila Neshatian, Rose Khavari
Patients with primary neurologic conditions often experience urinary and bowel dysfunction due to loss of sensory and/or motor control. Neurogenic bowel dysfunction is frequently characterized by both constipation and fecal incontinence. In general, the management of neurogenic bowel dysfunction has been less well studied than bladder dysfunction despite their close association.. It is widely accepted that establishment of a multifaceted bowel regimen is the cornerstone of conservative management. Continuing assessment is necessary to determine need for more invasive interventions...
December 2016: Current Bladder Dysfunction Reports
https://www.readbyqxmd.com/read/28716317/long-term-complications-of-the-neurogenic-bladder
#10
REVIEW
Unwanaobong Nseyo, Yahir Santiago-Lastra
It is widely accepted that neurogenic lower urinary tract dysfunction, when left untreated, has a natural history that has a potential for causing deterioration of renal function over time. However, certain patient profiles are at risk for this and other complications. This can be linked to their underlying neurologic disease process. Identifying risk profiles allows the provider to determine what surveillance strategies might be adopted. Risk factors for upper urinary tract deterioration include loss of bladder compliance, repeated bouts of pyelonephritis, and chronic indwelling catheterization...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28714784/the-management-of-paediatric-neurogenic-bladder-an-approach-in-a-resource-poor-setting
#11
Patrick Opoku Manu Maison, John Lazarus
BACKGROUND: If untreated, paediatric neurogenic bladder can cause renal failure and urinary incontinence. It is usually caused by neural tube defects such as myelomeningocele. Children with a neurogenic bladder should be monitored from birth and management should aim to preserve renal function and achieve social continence. This article outlines the management options appropriate for these children in resource-poor settings. ASSESSMENT: In most low- and middle-income countries, a general lack of awareness of the neurological effects on the urinary tract results in late presentation, usually with urological complications even when spina bifida is diagnosed early...
July 17, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28709886/five-year-follow-up-results-of-a-prospective-multicenter-study-in-overactive-bladder-subjects-treated-with-sacral-neuromodulation
#12
Steven Siegel, Karen Noblett, Jeffrey Mangel, Jason Bennett, Tomas L Griebling, Suzette E Sutherland, Erin T Bird, Craig Comiter, Daniel Culkin, Samuel Zylstra, Fangyu Kan, Kellie Chase Berg
OBJECTIVE: To evaluate therapeutic success rate, changes in quality of life (QOL) and safety with sacral neuromodulation (SNM) at 5 years after InterStim™ implant. Subjects with bothersome symptoms of overactive bladder (OAB) including urinary urge incontinence (UI) and/or urgency-frequency (UF), who had failed at least 1 anticholinergic medication and had at least 1 medication untried were included. METHODS: Therapeutic success was defined as a UI or UF response: ≥ 50% improvement in average leaks or voids/day or a return to normal voiding (<8 voids/day)...
July 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28708791/self-reported-long-term-autonomic-function-after-laparoscopic-total-mesometrial-resection-for-early-stage-cervical-cancer-a-multicentric-study
#13
Alessandro Lucidi, Swetlana Windemut, Marco Petrillo, Margherita Dessole, Giulio Sozzi, Giuseppe Filiberto Vercellino, Kaven Baessler, Giuseppe Vizzielli, Jalid Sehouli, Giovanni Scambia, Vito Chiantera
OBJECTIVES: This multicentric retrospective study investigates the early and long-term self-reported urinary, bowel, and sexual dysfunctions in early-stage cervical cancer patients who submitted to laparoscopic total mesometrial resection (L-TMMR), total laparoscopic radical hysterectomy, vaginal-assisted laparoscopic radical hysterectomy, and laparoscopic-assisted radical vaginal hysterectomy. METHODS: Cervical cancer patients, FIGO (International Federation of Gynecology and Obstetrics) stage IA2-IB1/IIA1 who submitted to nerve-sparing radical hysterectomy were recruited...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28707096/-medical-quality-standards-for-selected-urological-aids-and-devices-consensus-for-patients-with-neurogenic-urinary-bladder-dysfunction
#14
J Bremer, B Domurath, R Böthig, A Kaufmann, V Geng
BACKGROUND: Using the CE mark of therapeutic appliances is, on its own, not sufficient enough for their appropriate and effective application. In order to treat the patient successfully, not jeopardizing the success of the treatment, medical quality criteria for therapeutic appliances care are necessary to acceptably compensate for a patient's disabilities. OBJECTIVES: Medical quality criteria are formulated for the most frequently used urological aids and devices, considering hygienic requirements, international literature and the practical experience of physicians and nurses with regard to the care of patients with neurogenic urinary bladder dysfunction...
July 13, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28705713/sn003-a-crf1-receptor-antagonist-attenuates-depressive-like-behavior-and-detrusor-overactivity-symptoms-induced-by-13-cis-retinoic-acid-in-rats
#15
Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Piotr Wlaź, Tomasz Rechberger
Overactive bladder (OAB) often co-exists with depression in women. The corticotropin-releasing factor (CRF) system participates in the pathophysiology of both disorders. Therefore, we tested the effects of acute treatment with a reversible CRF receptor type-1 (CRF1) antagonist, SN003 (1mg/kg, i.v.), representatives of first (solifenacin, 0.03mg/kg, i.v.) and second (mirabegron, 1mg/kg, i.v.) line treatments for OAB as well as an antidepressant imipramine (30mg/kg, i.p.) on changes in behavior and detrusor overactivity (DO) symptoms induced by a 6-week administration of 13-cis-retinoic acid (13-cis-RA, 1mg/kg/day, i...
July 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28694616/reoperation-in-spinal-dysraphism-does-it-help-in-reversing-the-neurological-deficits
#16
Praful Suresh Maste, Yadhu Kasetti Lokanath, Shambhulingappa S Mahantshetti
AIMS: After initial primary repair by inexperienced hands for the spectrum of pathological conditions in spinal dysraphism (SD), a few percentage of patients present with recurrent symptoms and worsening neurological status especially when primarily pathology is not identified and dealt properly. When the primary intradural tethering element is left untouched, worsening of symptoms is common. In this retrospective study, we tried to analyze the symptomatology, functional outcome at 1-2 months after the second surgery and associated complications...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28689526/tension-free-vaginal-taping-in-pakistani-women-with-stress-urinary-incontinence
#17
Ayesha Saleem
OBJECTIVE: To evaluate the effectiveness and determine the peroperative and postoperative complications of tension-free vaginal tape (TVT) sling for urinary stress incontinence (USI) and contributing factors to complications. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Kidney Centre Postgraduate Institute, Karachi, from January 2009 to December 2010. METHODOLOGY: One hundred consecutive patients underwent TVT as per Ulmsten Technique for urinary stress incontinence and patients were followed for 3 years...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28689244/changes-in-management-of-poorly-compliant-bladder-in-botulinum-toxin-a-era
#18
REVIEW
Nachiketh Soodana Prakash, Diana M Lopategui, Christopher Gomez
Bladder compliance is a measure of distensibility. Maladies such as myelodysplasia, myelomeningocele, spinal cord injury, multiple sclerosis and obstructive uropathy are known to decrease bladder compliance. Decrease in bladder compliance is a characteristic of neurogenic bladders. The pathophysiology of bladder compliance is complex but ultimately leads to high pressure during filling and storage phases. These high pressures lead to renal impairment, incontinence, and recurrent urinary tract infections. This review presents management of poorly compliant bladders with onabotulinumtoxinA...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28689238/transobturator-midurethral-sling-what-should-patients-expect-after-surgery
#19
Tomasz Rechberger, Andrzej Wrobel, Alicja Zietek, Ewa Rechberger, Michal Bogusiewicz, Pawel Miotla
INTRODUCTION AND HYPOTHESIS: Midurethral sling (MUS) surgeries are minimally invasive procedures; however, they are not free of postoperative complications. The aim of the study was to assess the occurrence of lower urinary tract symptoms (LUTS) (urgency, nocturia, frequency, splitting/spraying, hesitancy, terminal dribbling, and subjective feeling of postvoid residual) in patients suffering from stress (SUI) or mixed (MUI) urinary incontinence with a predominant SUI component before and after transobturator MUS placement...
July 8, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28682451/outcomes-for-patients-with-apparent-chronic-idiopathic-pelvic-pain-and-associated-pelvic-floor-disorders-undergoing-laparoscopic-ventral-mesh-rectopexy
#20
A Newman, G L Greenslade, K McCarthy, A R Dixon
AIM: To assess the outcomes for patients with chronic idiopathic pelvic pain (CIPP) and associated pelvic floor disorders (PFDs) undergoing laparoscopic ventral mesh rectopexy (LVMR). METHOD: A prospective database identified patients referred from a specialist pain clinic undergoing LVMR. Primary outcomes included numerical rating scale (NRS) for pain, quality of life (QoL), Wexner constipation score, Cleveland Clinic incontinence score (CCIS), bowel and bladder-disturbance visual analogue scale (VAS) pain score and sexual function...
July 6, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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