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Therapeutic colonoscopy

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https://www.readbyqxmd.com/read/28325724/air-everywhere-colon-perforation-after-colonoscopy
#1
Ana Virgínia Araújo, Cláudia Santos, Helena Contente, Cláudia Branco
Colonoscopy is being widely used since the 1980s and is the leading diagnostic procedure for colorectal cancer. For many colorectal diseases, it is also a therapeutic tool. Like many other procedures in Medicine, it has its drawbacks and complications, some of which if not readily diagnosed can represent a serious risk to the patient's health and well-being. We describe a case of colon perforation during diagnostic colonoscopy in a patient, resulting in exuberant pneumoretroperitoneum, pneumoperitoneum, pneumomediastinum and subcutaneous emphysema, who successfully underwent laparoscopic colonic resection with primary anastomosis...
March 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28303842/improvement-of-quality-of-nonanesthetic-colonoscopy-by-preoperative-administration-of-pinaverium-bromide
#2
Xiao-Lin Wang, Jian-Ning Zhou, Li Ren, Xiao-Li Pan, Hong-Yu Ren, Jun Liu
BACKGROUND: Nonanesthetic colonoscopy is popular in clinical practice in China. However, intestinal spasms often result in a prolonged examination time, increased operating difficulties, decreased polyp detection rate, and failure to complete the procedure clinically. Therefore, exploring alternative approaches that can reduce the pain in patients during colonoscopy is of utmost importance, and finding the optimal preoperative administration to improve the quality of nonanesthetic colonoscopy is also necessary...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28272700/use-of-robotic-colonoscopy-in-patients-with-previous-incomplete-colonoscopy
#3
E Tumino, G Parisi, M Bertoni, M Bertini, S Metrangolo, E Ierardi, R Cervelli, G Bresci, R Sacco
OBJECTIVE: Conventional colonoscopy (CC) is the gold standard to diagnostic and therapeutic approach to colon. However, in few cases, cecal intubation could fail due to colon anatomy, patient compliance and physician expertise. Endotics robotic colonoscopy is a novel, safe, mini-invasive modality to explore the entire colon. Our aim was to assess, in a retrospective study, Endotics ability of cecal intubation in all cases in which CC failed. PATIENTS AND METHODS: Between January 2008 and December 2012, 276 Endotics robotic colonscopy examinations were performed at the Gastroenterology and Metabolic Diseases Unit of Pisa University Hospital, Pisa, Italy, in a series of consecutive patients who had undergone CC and failed cecal intubation...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28271317/cholinergic-anti-inflammatory-pathway-does-not-contribute-to-prevention-of-ulcerative-colitis-by-novel-indoline-carbamates
#4
Helena Shifrin, Odelia Mouhadeb, Nathan Gluck, Chen Varol, Marta Weinstock
Indoline carbamates, AN680 and AN917 decrease cytokines, TNF-α and IL-6 in peritoneal macrophages activated by lipopolysaccharide (LPS) and in mouse tissues after LPS injection. They prevent nuclear translocation of nuclear factor κB (NF-κB) and activator protein 1. Only AN917 inhibits cholinesterase (ChE) at relevant concentrations. ChE inhibitors decrease NF-κB by activating α7 nicotinic acetylcholine receptors (α7nAChR). The current study compared the effect of rivastigmine, a ChE inhibitor, AN680 and AN917 on ulcerative colitis induced in mice by ingestion of dextran sodium sulfate (4...
March 7, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28262219/does-urgent-colonoscopy-improve-outcomes-in-the-management-of-lower-gastrointestinal-bleeding
#5
REVIEW
Ankur Seth, Muhammad Ali Khan, Richard Nollan, Deepansh Gupta, Sehrish Kamal, Utkarsh Singh, Faisal Kamal, Colin W Howden
Colonoscopy continues to be an essential diagnostic and therapeutic tool in the management of lower gastrointestinal bleeding (LGIB). Studies that have evaluated the role of urgent colonoscopy for treating LGIB have reached conflicting conclusions. We conducted a systematic review and meta-analysis to evaluate the role of urgent colonoscopy in several outcomes in patients with LGIB. We searched Medline, Embase, Scopus and Cochrane databases from inception to July 10, 2016 for comparative studies evaluating the role of urgent versus elective colonoscopy in the management of LGIB...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28257124/hyper-methylated-loci-persisting-from-sessile-serrated-polyps-to-serrated-cancers
#6
Angeline S Andrew, John A Baron, Lynn F Butterly, Arief A Suriawinata, Gregory J Tsongalis, Christina M Robinson, Christopher I Amos
Although serrated polyps were historically considered to pose little risk, it is now understood that progression down the serrated pathway could account for as many as 15%-35% of colorectal cancers. The sessile serrated adenoma/polyp (SSA/P) is the most prevalent pre-invasive serrated lesion. Our objective was to identify the CpG loci that are persistently hyper-methylated during serrated carcinogenesis, from the early SSA/P lesion through the later cancer phases of neoplasia development. We queried the loci hyper-methylated in serrated cancers within our rightsided SSA/Ps from the New Hampshire Colonoscopy Registry, using the Illumina Infinium Human Methylation 450 k panel to comprehensively assess the DNA methylation status...
March 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28250907/the-impact-of-the-introduction-of-formalised-polypectomy-assessment-on-training-in-the-uk
#7
Kinesh Patel, Omar Faiz, Matt Rutter, Paul Dunckley, Siwan Thomas-Gibson
OBJECTIVE: The aim was to describe the impact on polypectomy experience by the mandatory introduction of the Directly Observed Polypectomy Skills tool (DOPyS) and electronic portfolio as part of the formal colonoscopy certification process. DESIGN: Applications for colonoscopy certification in the UK in the year prior to the introduction of DOPyS were analysed retrospectively and compared with data collected prospectively for those in the following year. SETTING: UK National Health Service...
April 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28242162/molecular-screening-for-lynch-syndrome-in-young-patients-with-colorectal-adenomas
#8
Robin B Mendelsohn, Keri Herzog, Jinru Shia, Nadiyah Rahaman, Zsofia K Stadler, Moshe Shike
BACKGROUND: The frequency of mismatch repair (MMR) deficiency (dMMR) in patients < 50 years with adenomas without a known germline mutation is unknown. Our aim was to define the frequency of dMMRs in adenomas from patients aged < 50 years. PATIENTS AND METHODS: We identified all patients aged 18 to 49 years who had undergone colonoscopy at Memorial Sloan Kettering Cancer Center from 2008 to 2013 and were identified as having tubular, villous, or tubulovillous adenomas on pathology...
February 2, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28238954/histologic-normalization-occurs-in-ulcerative-colitis-and-is-associated-with-improved-clinical-outcomes
#9
Britt Christensen, Stephen B Hanauer, Jonathan Erlich, Olufemi Kassim, Peter R Gibson, Jerrold R Turner, John Hart, David T Rubin
BACKGROUND & AIMS: Mucosal healing, determined by histologic analysis, is a potential therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of tissue normalization, as an outcome of treatment, have not been well described. We examined the prevalence and predictive values of normalization of the colonic mucosa, based on histologic analysis (histologic normalization) in patients with UC, and determined its association with risk of clinical relapse, compared to disease quiescence and mucosal healing...
February 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28229609/laparoscopic-treatment-of-hemorrhagic-meckel-diverticulum-after-diagnosis-with-wireless-capsule-endoscopy-and-double-balloon-enteroscopy
#10
Haibo Yu, Hongliang Song, Jing Cai
Meckel diverticulum (MD) is a common small intestinal malformation. The difficulty of MD with hemorrhage treatment lies in preoperative diagnosis. Wireless capsule endoscopy (WCE) and double-balloon enteroscopy (DBE) have been widely used to diagnose and treat diseases of the small intestine, but only rarely have they been used in combination to diagnose and treat bleeding MD. We successfully diagnosed and treated a patient with MD with hemorrhage with a combination of WCE, DBE, and laparoscopy. A 17-year-old man presented to the emergency room with hematochezia and was admitted for testing...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229607/therapeutic-impact-of-colon-capsule-endoscopy-with-pillcam%C3%A2-colon-2-after-incomplete-standard-colonoscopy-a-spanish-multicenter-study
#11
Óscar Nogales, Javier García-Lledó, Marisol Luján, David Nicolás, José Francisco Juanmartiñena, Begoña González-Suárez, Francisco Sánchez Ceballos, Ignacio Couto, José Olmedo, Cristina Garfia, Cristina Carretero, Ignacio Fernández Urién, Sarbelio Rodríguez, Matilde Asteinza, Pilar Olivencia, Ángeles Masedo, Miguel Muñoz-Navas, Beatriz Merino, Cecilia González Asanza
INTRODUCTION: Colon capsule endoscopy (CCE) is an alternative approach for the examination of the colon in patients who refuse colonoscopy or after incomplete colonoscopy (IC). We conducted a study to determine the frequency of complete colonoscopy after IC, the diagnostic yield of CCE, the therapeutic impact of lesions found in CCE, the level of colon cleanliness and the safety of the procedure. METHODS: We performed a prospective, multicenter study involving ten Spanish hospitals...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28184237/laparoscopic-vs-open-surgery-for-the-treatment-of-iatrogenic-colonoscopic-perforations-a-systematic-review-and-meta-analysis
#12
REVIEW
Aleix Martínez-Pérez, Nicola de'Angelis, Francesco Brunetti, Yann Le Baleur, Carmen Payá-Llorente, Riccardo Memeo, Federica Gaiani, Marco Manfredi, Paschalis Gavriilidis, Giorgio Nervi, Federico Coccolini, Aurelien Amiot, Iradj Sobhani, Fausto Catena, Gian Luigi de'Angelis
AIMS: Iatrogenic colonoscopy perforations (ICP) are a rare but severe complication of diagnostic and therapeutic colonoscopies. The present systematic review and meta-analysis aims to investigate the operative and post-operative outcomes of laparoscopy vs. open surgery performed for the management of ICP. METHODS: A literature search was carried out on Medline, EMBASE, and Scopus databases from January 1990 to June 2016. Clinical studies comparing the outcomes of laparoscopic and open surgical procedures for the treatment for ICP were retrieved and analyzed...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28174123/urgent-colonoscopy-in-patients-with-lower-gastrointestinal-bleeding-a-systematic-review-and-meta-analysis
#13
REVIEW
Abdul M Kouanda, Ma Somsouk, Justin L Sewell, Lukejohn W Day
BACKGROUND AND AIMS: Lower GI bleeding is a common cause of morbidity and mortality. Colonoscopy is indicated in all hospitalized patients with lower gastrointestinal bleeding, yet the time frame for performing colonoscopy remains unclear. Prior studies of outcomes in urgent versus elective colonoscopy have yielded conflicting results and were often underpowered. Our study objective was to compare several outcomes between urgent and elective colonoscopy in patients hospitalized for lower GI bleeding...
February 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28128877/endoscopic-findings-of-ipilimumab-induced-colitis
#14
Tatsunori Satoh, Kazuya Ohno, Takafumi Kurokami
Ipilimumab is a fully humanized monoclonal antibody targeting inhibitory cytotoxic T-lymphocyte-associated antigen-4 on T cells, thereby enhancing antitumor immunity.(1) While ipilimumab has significant therapeutic benefit, it induces hypersensitivity reactions in some targeted organs. Ipilimumab-induced colitis (IiC) is one such hypersensitivity reaction, clinically manifesting as colitis.(2) Colonoscopy is helpful in diagnosing IiC. The macroscopic and microscopic features of IiC include friable erythematous mucosa and ulcers with an absent vascular pattern...
January 27, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28089622/serum-procalcitonin-correlates-with-colonoscopy-findings-and-can-guide-therapeutic-decisions-in-postoperative-ischemic-colitis
#15
C Cossé, C Sabbagh, M Fumery, E Zogheib, F Mauvais, F Browet, L Rebibo, J M Regimbeau
BACKGROUND: Postoperative ischaemic colitis (POIC) is a life-threatening vascular gastrointestinal condition. Serum procalcitonin (PCT) levels be of value in the detection of necrosis. AIMS: To evaluate the correlation between serum PCT levels and the colonoscopic assessment of the severity of POIC. METHODS: Between January 2007 and November 2014, 150 patients with POIC and PCT data were included in the study. The main outcome measure was the correlation between serum PCT and the colonoscopy-based assessment of the severity of POIC (according to Favier's classification: stage 1/2 without multi-organ failure vs...
December 15, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28069255/is-urgent-ct-angiography-necessary-in-cases-of-acute-lower-gastrointestinal-bleeding
#16
A Martín Díaz, L Fernández Rodríguez, M Martí de Gracia
Acute lower gastrointestinal bleeding usually presents as hematochezia, rectal bleeding or melena and represents 1-2% of the medical appointments in the Emergency Services. Mortality reaches the 30-40% and it is highly related with the severity and associated comorbidity. Most clinical practice guidelines include colonoscopy at some point in the diagnostic and therapeutic process (urgent for severe cases and ambulatory for mild ones) and look for predictors of severity. In the last years, there have been numerous studies where is clear the relevance and complementarity of advanced diagnostic imaging techniques, gradually incorporated as an alternative or second step in severe cases...
January 6, 2017: Radiología
https://www.readbyqxmd.com/read/28068728/-a-rare-case-of-coecal-volvulus-after-colonoskopy-due-to-a%C3%A2-mobile-coekum-diagnosis-surgical-therapy-and-postoperative-complications
#17
Christian Beltzer, Axel Geiger, Roland Schmidt, Burkhardt Danz, Amrei Maier, Richard Karpa, Nektarios Dikopoulos
Colonoscopy, either performed as screening or as a therapeutic proceedure, is, in general, very safe with only a few cases of serious complications. Most cases of bleeding after endoscopic polypectomy can be safely managed endoscopically. The rare cases of colonic perforations still have to be managed by surgical intervention. The postpolypectomy-coagulation syndrome and a cecal volvulus are very rare complicatoions after colonoscopy. In the current manuscript, we describe a rare case of a cecal volvulus after routine colonoscopy due to an unknown mobile coecum as a predisposition...
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28040600/predictive-and-prognostic-biomarkers-in-colorectal-cancer-a-systematic-review-of-recent-advances-and-challenges
#18
REVIEW
Vishal Das, Jatin Kalita, Mintu Pal
BACKGROUND: Colorectal cancer (CRC) is one of the leading cause of cancer deaths worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced stages, the implementation of the screening programme is very much essential to reduce cancer incidence and mortality rates. CRC occurs predominantly from accumulation of genetic and epigenetic changes in colon epithelial cells, which later gets transformed into adenocarcinomas. SCOPE OF REVIEW: The current challenges of screening paradigm and diagnostic ranges are from semi-invasive methods like colonoscopy to non-invasive stool-based test, have resulted in over-diagnosis and over-treatment of CRC...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27931639/complications-in-pediatric-endoscopy
#19
REVIEW
Andrea Tringali, Valerio Balassone, Paola De Angelis, Rosario Landi
The experience of the "endoscopic community" in pediatric patients is limited, but during recent years increased skills of the endoscopists and technological improvements lead to a standardization of pediatric endoscopy and the development of specialized pediatric endoscopy unit. Adverse events related to diagnostic and therapeutic endoscopy in children are usually rare. Diagnosis, prevention and treatment of complications in pediatric endoscopy is crucial when dealing with benign diseases in children. The complication rate of diagnostic EGD and colonoscopy in children are extremely low...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27931632/complications-of-therapeutic-gastroscopy-colonoscopy-other-than-resection
#20
REVIEW
Zaheer Nabi
Gastrointestinal (GI) endoscopy is profoundly utilized for diagnostic and therapeutic purposes. The therapeutic potential of GI endoscopy has amplified many folds with the evolution of novel techniques as well as equipments. However, with the augmentation of therapeutic endoscopy, the extent, likelihood and severity of adverse events have increased as well. The attendant risks and adverse events with therapeutic endoscopy are many folds that of diagnostic endoscopy. Besides endoscopic resection, therapeutic endoscopy is widely utilized for hemostasis in GI bleeds, dilatation of stenosis, enteral stenting, foreign body removal, ablation of Barrett's esophagus etc...
October 2016: Best Practice & Research. Clinical Gastroenterology
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