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Therapeutic colonoscopy

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https://www.readbyqxmd.com/read/28089622/serum-procalcitonin-correlates-with-colonoscopy-findings-and-can-guide-therapeutic-decisions-in-postoperative-ischemic-colitis
#1
C Cossé, C Sabbagh, M Fumery, E Zogheib, F Mauvais, F Browet, L Rebibo, J M Regimbeau
BACKGROUND: Postoperative ischaemic colitis (POIC) is a life-threatening vascular gastrointestinal condition. Serum procalcitonin (PCT) levels be of value in the detection of necrosis. AIMS: To evaluate the correlation between serum PCT levels and the colonoscopic assessment of the severity of POIC. METHODS: Between January 2007 and November 2014, 150 patients with POIC and PCT data were included in the study. The main outcome measure was the correlation between serum PCT and the colonoscopy-based assessment of the severity of POIC (according to Favier's classification: stage 1/2 without multi-organ failure vs...
December 15, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28069255/is-urgent-ct-angiography-necessary-in-cases-of-acute-lower-gastrointestinal-bleeding
#2
A Martín Díaz, L Fernández Rodríguez, M Martí de Gracia
Acute lower gastrointestinal bleeding usually presents as hematochezia, rectal bleeding or melena and represents 1-2% of the medical appointments in the Emergency Services. Mortality reaches the 30-40% and it is highly related with the severity and associated comorbidity. Most clinical practice guidelines include colonoscopy at some point in the diagnostic and therapeutic process (urgent for severe cases and ambulatory for mild ones) and look for predictors of severity. In the last years, there have been numerous studies where is clear the relevance and complementarity of advanced diagnostic imaging techniques, gradually incorporated as an alternative or second step in severe cases...
January 6, 2017: Radiología
https://www.readbyqxmd.com/read/28068728/-a-rare-case-of-coecal-volvulus-after-colonoskopy-due-to-a%C3%A2-mobile-coekum-diagnosis-surgical-therapy-and-postoperative-complications
#3
Christian Beltzer, Axel Geiger, Roland Schmidt, Burkhardt Danz, Amrei Maier, Richard Karpa, Nektarios Dikopoulos
Colonoscopy, either performed as screening or as a therapeutic proceedure, is, in general, very safe with only a few cases of serious complications. Most cases of bleeding after endoscopic polypectomy can be safely managed endoscopically. The rare cases of colonic perforations still have to be managed by surgical intervention. The postpolypectomy-coagulation syndrome and a cecal volvulus are very rare complicatoions after colonoscopy. In the current manuscript, we describe a rare case of a cecal volvulus after routine colonoscopy due to an unknown mobile coecum as a predisposition...
January 9, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28040600/predictive-and-prognostic-biomarkers-in-colorectal-cancer-a-systematic-review-of-recent-advances-and-challenges
#4
REVIEW
Vishal Das, Jatin Kalita, Mintu Pal
BACKGROUND: Colorectal cancer (CRC) is one of the leading cause of cancer deaths worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced stages, the implementation of the screening programme is very much essential to reduce cancer incidence and mortality rates. CRC occurs predominantly from accumulation of genetic and epigenetic changes in colon epithelial cells, which later gets transformed into adenocarcinomas. SCOPE OF REVIEW: The current challenges of screening paradigm and diagnostic ranges are from semi-invasive methods like colonoscopy to non-invasive stool-based test, have resulted in over-diagnosis and over-treatment of CRC...
December 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27931639/complications-in-pediatric-endoscopy
#5
REVIEW
Andrea Tringali, Valerio Balassone, Paola De Angelis, Rosario Landi
The experience of the "endoscopic community" in pediatric patients is limited, but during recent years increased skills of the endoscopists and technological improvements lead to a standardization of pediatric endoscopy and the development of specialized pediatric endoscopy unit. Adverse events related to diagnostic and therapeutic endoscopy in children are usually rare. Diagnosis, prevention and treatment of complications in pediatric endoscopy is crucial when dealing with benign diseases in children. The complication rate of diagnostic EGD and colonoscopy in children are extremely low...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27931632/complications-of-therapeutic-gastroscopy-colonoscopy-other-than-resection
#6
REVIEW
Zaheer Nabi
Gastrointestinal (GI) endoscopy is profoundly utilized for diagnostic and therapeutic purposes. The therapeutic potential of GI endoscopy has amplified many folds with the evolution of novel techniques as well as equipments. However, with the augmentation of therapeutic endoscopy, the extent, likelihood and severity of adverse events have increased as well. The attendant risks and adverse events with therapeutic endoscopy are many folds that of diagnostic endoscopy. Besides endoscopic resection, therapeutic endoscopy is widely utilized for hemostasis in GI bleeds, dilatation of stenosis, enteral stenting, foreign body removal, ablation of Barrett's esophagus etc...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27914657/ulcerative-colitis
#7
REVIEW
Ryan Ungaro, Saurabh Mehandru, Patrick B Allen, Laurent Peyrin-Biroulet, Jean-Frédéric Colombel
Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Patients with ulcerative colitis have mucosal inflammation starting in the rectum that can extend continuously to proximal segments of the colon. Ulcerative colitis usually presents with bloody diarrhoea and is diagnosed by colonoscopy and histological findings...
November 30, 2016: Lancet
https://www.readbyqxmd.com/read/27904859/endoscopic-approach-for-superficial-colorectal-neoplasms
#8
REVIEW
Jun-Feng Xu, Lang Yang, Peng Jin, Jian-Qiu Sheng
BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females, with an estimated 1.4 million cases and 693,900 deaths in 2012. Colonoscopy is the cornerstone for the detection and prevention of CRC. In addition, endoscopic treatment for CRC at an early stage can effectively improve patients' quality of life and cure rate. SUMMARY: This review focuses on endoscopic approaches, including white light endoscopy, chromoendoscopy, magnifying endoscopy and therapeutic endoscopy, for the evaluation and treatment of superficial colorectal neoplasms...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27894604/evaluation-of-the-efficacy-of-therapeutic-endoscopy-in-gastrointestinal-bleeding-secondary-to-angiodysplasias
#9
J Arribas Anta, C Zaera de la Fuente, R Martín Mateos, J A González Martín, A Cañete Ruiz, D Boixeda de Miquel, A Albillos Martínez
INTRODUCTION: Gastrointestinal angiodysplasias are defined as vascular dilations that communicate capillaries and veins in the walls of the digestive tract. The clinical presentation of these lesions varies from chronic occult bleeding to severe gastrointestinal hemorrhage. AIM: The primary aim of our study was to analyze lesion location, the efficacy of therapeutic endoscopy with argon plasma coagulation, and the factors associated with rebleeding in patients with gastrointestinal angiodysplasias...
November 25, 2016: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/27893543/changes-in-intestinal-microbiota-following-combination-therapy-with-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#10
Dai Ishikawa, Takashi Sasaki, Taro Osada, Kyoko Kuwahara-Arai, Keiichi Haga, Tomoyoshi Shibuya, Keiichi Hiramatsu, Sumio Watanabe
BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM alone. METHODS: AFM therapy was administered to patients for 2 weeks until 2 days before FMT...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27886554/a-biomaterial-assisted-mesenchymal-stromal-cell-therapy-alleviates-colonic-radiation-induced-damage
#11
Lara Moussa, Girish Pattappa, Bastien Doix, Sarra-Louiza Benselama, Christelle Demarquay, Marc Benderitter, Alexandra Sémont, Radia Tamarat, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Noëlle Mathieu
Healthy tissues surrounding abdomino-pelvic tumours can be impaired by radiotherapy, leading to chronic gastrointestinal complications with substantial mortality. Adipose-derived Mesenchymal Stromal Cells (Ad-MSCs) represent a promising strategy to reduce intestinal lesions. However, systemic administration of Ad-MSCs results in low cell engraftment within the injured tissue. Biomaterials, able to encapsulate and withstand Ad-MSCs, can overcome these limitations. A silanized hydroxypropylmethyl cellulose (Si-HPMC) hydrogel has been designed and characterized for injectable cell delivery using the operative catheter of a colonoscope...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27879485/patients-views-on-fecal-microbiota-transplantation-an-acceptable-therapeutic-option-in-inflammatory-bowel-disease
#12
Jonas Zeitz, Marina Bissig, Christiane Barthel, Luc Biedermann, Sylvie Scharl, Daniel Pohl, Pascal Frei, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl
BACKGROUND: Fecal microbiota transplantation (FMT) represents a new therapeutic option that has been studied in two randomized-controlled trials in ulcerative colitis patients. Our study aimed to identify patients' views on the use of this novel therapeutic approach. METHODS: Using an anonymous questionnaire, we obtained data from 574 inflammatory bowel disease (IBD) patients on their knowledge and willingness to undergo FMT. RESULTS: A large proportion of IBD patients (53...
November 22, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27873506/development-of-a-robotic-colonoscopic-manipulation-system-using-haptic-feedback-algorithm
#13
Jaehong Woo, Jae Hyuk Choi, Jong Tae Seo, Tae Il Kim, Byung Ju Yi
PURPOSE: Colonoscopy is one of the most effective diagnostic and therapeutic tools for colorectal diseases. We aim to propose a master-slave robotic colonoscopy that is controllable in remote site using conventional colonoscopy. MATERIALS AND METHODS: The master and slave robot were developed to use conventional flexible colonoscopy. The robotic colonoscopic procedure was performed using a colonoscope training model by one expert endoscopist and two unexperienced engineers...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27852099/meta-analysis-of-the-performance-of-ultrathin-vs-standard-colonoscopes
#14
Aijaz Ahmed Sofi, Ali Nawras, Muhammad Ali Khan, Colin W Howden, Wade M Lee
Background and study aims: Colonoscopy should reliably intubate the cecum with minimal patient discomfort and without complications. Use of thinner endoscopes to overcome pain during the procedure has shown promise. However, the use of thinner scopes could lead to excess looping and difficulty with therapeutic procedures. The aim of this meta-analysis was to analyze the performance of ultrathin colonoscopes (UTC) and standard colonoscopes for routine colonoscopy. Patients and methods: We searched several electronic databases for all randomized controlled trials and nonrandomized (prospective) studies that compared the efficacies of UTC (diameter ≤ 9...
November 16, 2016: Endoscopy
https://www.readbyqxmd.com/read/27821025/adult-intussusception-10-year-experience-in-two-belgian-centres
#15
F de Clerck, E Vanderstraeten, M De Vos, C Van Steenkiste
BACKGROUND: adult intussusception is a rare entity with a different clinical presentation and aetiology than in children. Objective: To provide a comprehensive overview of the clinical presentation, aetiology, diagnosis and management of adult intussusception. METHODS: We review 43 cases with a preoperative diagnosis of symptomatic gastrointestinal adult intussusception. RESULTS: In 67% of the cases an underlying lead point was discovered...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27813111/endoscopic-and-clinical-responses-to-anti-tubercular-therapy-can-differentiate-intestinal-tuberculosis-from-crohn-s-disease
#16
V Pratap Mouli, K Munot, A Ananthakrishnan, S Kedia, S Addagalla, S K Garg, J Benjamin, V Singla, R Dhingra, V Tiwari, S Bopanna, S Hutfless, G Makharia, V Ahuja
BACKGROUND: Differentiation between intestinal tuberculosis and Crohn's disease is difficult and may require therapeutic trial with anti-tubercular therapy in tuberculosis-endemic regions. AIM: To evaluate the role of therapeutic trial with anti-tubercular therapy in patients with diagnostic confusion between intestinal tuberculosis and Crohn's disease. METHODS: We performed retrospective-comparative (n = 288: 131 patients who received anti-tubercular therapy before being diagnosed as Crohn's disease and 157 intestinal tuberculosis patients) and prospective-validation study (n = 55 patients with diagnostic confusion of intestinal tuberculosis/Crohn's disease)...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27807552/mucosa-associated-lymphoid-tissue-lymphoma-of-the-sigmoid-colon-discovered-on-routine-screening-colonoscopy-in-patient-with-hepatitis-c-and-helicobacter-pylori-infection
#17
Rajiv Bhuta, Michael Bromberg, Ashish Bains, Ron Schey
Mucosa-associated lymphoid tissue (MALT) lymphoma is predominantly found in the stomach. Rarely, it is found in the proximal colon and even less so in the sigmoid colon. We present a rare case of primary sigmoid colon MALT lymphoma in a patient with concomitant Helicobacter pylori and hepatitis C infection. We also review current imaging, staging, and therapeutic modalities. To our knowledge, this is the first sigmoid colon MALT lymphoma reported in the United States.
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27717791/patient-preferences-for-inflammatory-bowel-disease-treatment-objectives
#18
Francesc Casellas, Claudia Herrera-de Guise, Virginia Robles, Ester Navarro, Natalia Borruel
BACKGROUND: There is currently little evidence about what treatment objectives most interest patients with inflammatory bowel disease (IBD). AIMS: To determine patient preferences regarding IBD treatment objectives, specially the attributes they value most and the symptoms to be controlled as a priority. METHODS: Prospective, observational, anonymous study conducted in 117 outpatients with Crohn's disease or ulcerative colitis. RESULTS: The most important treatment objectives from the patients' perspective were: improving quality of life (40...
September 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27713779/the-impact-of-induction-therapy-with-three-doses-of-infliximab-on-deep-histological-healing-in-paediatric-patients-with-active-crohn-s-disease
#19
Edyta Szymanska, Maciej Dadalski, Sylwia Szymanska, Wieslawa Grajkowska, Maciej Pronicki, Jaroslaw Kierkus
INTRODUCTION: The clinical efficacy of infliximab (IFX) for induction of remission in both adults and children with active Crohn's disease (CD) has been well documented. Recently, so-called "deep remission" defined as mucosal healing has become the ultimate endpoint of the most recent therapeutic advances for CD. However, endoscopic evidence of mucosal healing is not necessarily associated with histological evidence of suppression of inflammation. AIM: Since data on that issue are limited, especially in the paediatric population, the aim of this study was to assess the impact of induction therapy with IFX on deep microscopic remission in paediatric patients with CD...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27706811/oncogenic-targets-mmp7-s100a9-nppb-and-aldh1a3-from-transcriptome-profiling-of-fap-and-pirc-adenomas-are-downregulated-in-response-to-tumor-suppression-by-clotam
#20
Furkan U Ertem, Wenqian Zhang, Kyle Chang, Wan Mohaiza Dashwood, Praveen Rajendran, Deqiang Sun, Ala Abudayyeh, Eduardo Vilar, Maen Abdelrahim, Roderick H Dashwood
Intervention strategies in familial adenomatous polyposis (FAP) patients and other high-risk colorectal cancer (CRC) populations have highlighted a critical need for endoscopy combined with safe and effective preventive agents. We performed transcriptome profiling of colorectal adenomas from FAP patients and the polyposis in rat colon (Pirc) preclinical model, and prioritized molecular targets for prevention studies in vivo. At clinically relevant doses in the Pirc model, the drug Clotam (tolfenamic acid, TA) was highly effective at suppressing tumorigenesis both in the colon and in the small intestine, when administered alone or in combination with Sulindac...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
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