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https://www.readbyqxmd.com/read/29342997/-x-linked-inhibitor-of-apoptosis-deficiency-manifested-as-crohn-s-disease-a-case-report-and-literature-review
#1
L J Xu, Y Y Luo, J D Yu, J G Lou, Y H Fang, J Chen
Objective: To analyze the clinical characteristics of X-linked inhibitor of apoptosis (XIAP) deficient patients with clinical manifestation of Crohn's disease. Methods: Clinical manifestations, laboratory investigations, genetic testing and therapeutic interventions of one case of XIAP deficiency who was admitted to Department of Gastroenterology in Children's Hospital, Zhejiang University School of Medicine in May 2016 were summarized. PubMed and Chinese database for articles published from January 2016 to June 2017 were searched using the key words of'Crohn's disease'and'XIAP', and the relevant literature was reviewed...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29283904/role-of-full-spectrum-endoscopy-in-colorectal-cancer-screening-randomized-trial
#2
Henar Núñez-Rodríguez, Pilar Diez-Redondo, Manuel Pérez-Miranda, Manuel Gonzalez Sagrado, Rosa Conde, Carlos De la Serna
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate...
December 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29260128/emergency-cases-following-elective-colonoscopy-iatrogenic-colonic-perforation
#3
Ebubekir Gündeş, Hüseyin Çiyiltepe, Ulaş Aday, Durmuş Ali Çetin, Aziz Serkan Senger, Orhan Uzun, Kamuran Cumhur Değer, Mustafa Duman, Erdal Polat
Objective: Our aim in this study was to present the cases of our patients who contracted colonic perforation during elective colonoscopy and became emergency cases; we also discuss treatment modalities along with literature reports on the subject. Material and Methods: Cases of patients who contracted iatrogenic colonic perforation following endoscopy of the colorectal system between January 2009 and December 2015 at Kartal Koşuyolu Yüksek İhtisas Training and Research Hospital's Endoscopy Unit were reviewed retrospectively...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29214422/emu-oil-improves-clinical-indicators-of-disease-in-a-mouse-model-of-colitis-associated-colorectal-cancer
#4
Lauren C Chartier, Gordon S Howarth, Ian C Lawrance, Debbie Trinder, Scott J Barker, Suzanne Mashtoub
BACKGROUND/AIMS: Ulcerative colitis is a remitting and relapsing inflammatory bowel disorder. Current treatments are limited, and if poorly controlled, colitis may progress to colorectal cancer. Previously, Emu Oil protected the intestine in experimental models of gut damage. We aimed to determine whether Emu Oil could reduce the severity of chronic colitis and prevent the onset of neoplasia in a mouse model of colitis-associated colorectal cancer. METHODS: Female C57BL/6 mice were injected (day 0) with azoxymethane, followed by ad libitum access to three dextran sulfate sodium/water cycles (7 days of dextran sulfate sodium and 14 days of water)...
December 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29210094/infliximab-trough-concentrations-during-maintenance-therapy-are-associated-with-endoscopic-and-histologic-healing-in-ulcerative-colitis
#5
K Papamichael, S Rakowsky, C Rivera, A S Cheifetz, M T Osterman
BACKGROUND: Endoscopic and histologic healing are emerging as new therapeutic goals in ulcerative colitis (UC), as these endpoints are associated with less relapse, hospitalization and colectomy. AIM: To investigate the association of serum infliximab trough concentrations during maintenance therapy with endoscopic or histologic healing in UC. METHODS: In this multi-center retrospective cohort study, we included consecutive patients with moderate-to-severe UC on infliximab maintenance therapy who had an endoscopic evaluation and underwent therapeutic drug monitoring within three months of the colonoscopy, between February 2008 and March 2016...
December 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29190999/animal-models-for-studying-inflammatory-bowel-diseases-ibd-a-meta-analysis-on-modalities-for-imaging-inflammatory-lesions
#6
Sveva Auletta, Rita Bonfiglio, Andreas Wunder, Michela Varani, Filippo Galli, Filippo Borri, Manuel Scimeca, Heiko G Niessen, Tanja Schönberger, Elena Bonanno
Inflammatory bowel diseases are lifelong disorders affecting the gastrointestinal tract characterized by intermittent disease flares and periods of remission with a progressive and destructive nature. Unfortunately, the exact etiology is still not completely known, therefore a causal therapy to cure the disease is not yet available. Current treatment options mainly encompass the use of non-specific anti- inflammatory agents and immunosuppressive drugs that cause significant side effects that often have a negative impact on patients' quality of life...
November 30, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29176078/one-stage-surgery-for-synchronous-liver-metastasis-from-a-neuroendocrine-tumor-of-the-colon-a-case-report
#7
Nicola Tartaglia, Alessandra Di Lascia, Pasquale Cianci, Alberto Fersini, Francesca Sanguedolce, Roberta Iadarola, Sabino Capuzzolo, Vincenzo Neri, Antonio Ambrosi
INTRODUCTION: Neuroendocrine tumors (NETs) are a heterogeneous group of tumors. NET of colon represent less than 1% of colonic tumors. Synchronous liver metastases, present in 75-80%, are considered significant adverse prognostic indicators. Liver is the second commonest site for metastasis in patients with colorectal neuroendocrine tumors. Available treatment options include surgical resection, chemotherapy, biotherapy. Surgery is the gold standard for curative therapy and it is strictly related to the localization, the grade of tumor, and the stage of disease...
November 20, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29147133/allopurinol-in-combination-with-thiopurine-induces-mucosal-healing-and-improves-clinical-and-metabolic-outcomes-in-ibd
#8
Brigitte Moreau, Pierre Clement, Yves Theoret, Ernest G Seidman
Background: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD). Excessive methylation via thiopurine methyltransferase (TPMT) frequently causes therapeutic failure. Allopurinol reduces excessive 6-methyl-mercaptopurine (6-MMP) while enhancing 6-thioguanine (6-TGN) levels. The aim of this study was to evaluate clinical, metabolic and endoscopic impact of allopurinol in combination with low-dose thiopurine in IBD...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29136128/the-proton-activated-receptor-gpr4-modulates-intestinal-inflammation
#9
Yu Wang, Cheryl de Vallière, Pedro H Imenez Silva, Irina Leonardi, Sven Gruber, Alexandra Gerstgrasser, Hassan Melham, Achim Weber, Katharina Leucht, Lutz Wolfram, Martin Hausmann, Carsten Krieg, Koray Thomasson, Onur Boyman, Isabelle Frey-Wagner, Gerhard Rogler, Carsten A Wagner
BACKGROUND AND AIMS: During active inflammation tissue intraluminal intestinal pH is decreased in patients with inflammatory bowel disease (IBD). Acidic pH may play a role in IBD pathophysiology. Recently, proton sensing G-protein coupled receptors were identified, including GPR4, OGR1 (GPR68), and TDAG8 (GPR65). We investigated whether GPR4 is involved in intestinal inflammation. METHODS: The role of GPR4 was assessed in murine colitis models: chronic dextran sulphate sodium (DSS) administration and by crossbreeding into an IL-10 deficient background for development of spontaneous colitis...
November 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29130220/-current-research-progress-and-thinking-of-fecal-microbiota-transplantation-for-the-treatment-of-gastrointestinal-disorders
#10
Ning Li, Hongliang Tian
Fecal microbiota transplantation (FMT), also known as fecal bacteriotherapy or fecal infusion, consists of injection of a liquid filtrate of feces from a healthy donor into the gastrointestinal tract of a recipient individual. FMT has been proposed as a therapeutic approach for functional diseases of the gastrointestinal tract by reestablishment of a wide diversity of intestinal flora. Clostridium difficile infection (CDI) treatment guideline from American Gastroenterology Association (AGA) recommends that FMT can be used as the treatment protocols of relapse CDI...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29122850/differential-preventive-activity-of-sulindac-and-atorvastatin-in-apc-min-fcccmice-with-or-without-colorectal-adenomas
#11
Wen-Chi L Chang, Christina Jackson, Stacy Riel, Harry S Cooper, Karthik Devarajan, Harvey H Hensley, Yan Zhou, Lisa A Vanderveer, Minhhuyen T Nguyen, Margie L Clapper
OBJECTIVE: The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tumour-bearing status at treatment initiation. DESIGN: Male mice (6-8 weeks old) underwent colonoscopy and received control chow or chow with sulindac (300 ppm), atorvastatin (100 ppm) or sulindac/atorvastatin...
November 9, 2017: Gut
https://www.readbyqxmd.com/read/29094497/iron-deficiency-anemia-in-older-adults-a-review
#12
REVIEW
Etienne Joosten
Anemia in older adults is a risk factor for numerous negative outcomes. There is no standard definition, but in most studies, anemia is defined as a hemoglobin value <12 g/dL for women and <13 g/dL for men. Absolute iron deficiency anemia is defined as the combination of anemia and the absence of total body iron. Serum ferritin is the most frequently used diagnostic parameter, but its concentration increases with age and in the presence of inflammatory diseases. Other laboratory tests, such as transferrin saturation, soluble transferrin receptor and the soluble transferrin receptor/ferritin index might provide useful information, but there is a wide variety in the cut-off values and interpretation of the results...
November 2, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29019557/colonoscopy-randomized-comparative-study-of-insufflation-with-carbon-dioxide-versus-air
#13
Luiz Gustavo DE-Quadros, Roberto Luiz Kaiser-Júnior, Valter Nilton Felix, Lucio Villar, Josemberg Marins Campos, Vinicius Quintiliano Moutinho Nogueira, André Teixeira, Idiberto José Zotarelli-Filho
BACKGROUND: In Brazil, an increasing number of people are submitted to colonoscopy, either for screening or for therapeutic purposes. AIM: To evaluate whether there are advantages of using carbon dioxide (CO2) over air for insufflation. METHODS: Two hundred and ten of 219 patients were considered eligible for this study and were randomized into two groups according to the gas insufflation used: Air Group (n=104) and CO2 Group (n=97). The study employed a double-blind design...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29019424/endoscopy-for-patients-affected-by-inflammatory-bowel-disease-bowel-preparation-and-sedation
#14
Cristina Bezzio, Paolo Andreozzi, Valentina Casini, Gianpiero Manes, Simone Saibeni
Endoscopy has a key role in the management of inflammatory bowel disease (IBD). It is helpful in the diagnosis, in case of relapse, refractoriness, before therapeutic changes, after surgery as well as in the assessment of mucosal healing and in the surveillance of colo-rectal cancer. IBD patients are intended to undergo several times the examination during their lifespan. Bowel preparation and sedation highly contribute to high-quality colonoscopy. Areas covered: Few studies addressed preparation and sedation in the field of IBD...
October 17, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28991857/impact-of-histological-and-endoscopic-remissions-on-clinical-recurrence-and-recurrence-free-time-in-ulcerative-colitis
#15
Ana Ponte, Rolando Pinho, Sónia Fernandes, Adélia Rodrigues, Luís Alberto, João Carlos Silva, Joana Silva, Jaime Rodrigues, Mafalda Sousa, Ana Paula Silva, Luísa Proença, Teresa Freitas, Sónia Leite, João Carvalho
BACKGROUND: Clinical and endoscopic remissions constitute the therapeutic goals in ulcerative colitis (UC). Histological healing is currently not a target in UC. This study aims to determine the impact of the definition of endoscopic remission (Mayo endoscopic subscore [MSe] 0-1) and histological activity in the recurrence of UC and recurrence-free survival time. METHODS: Patients with UC in clinical remission (partial Mayo score ≤ 1) and endoscopic remission (MSe ≤ 1) who underwent colonoscopy with biopsies between March 2010 and December 2013 were included...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28975147/diagnostic-and-therapeutic-treatment-modalities-for-acute-lower-gastrointestinal-bleeding-a-systematic-review
#16
REVIEW
Kathryn Oakland, Jennifer Isherwood, Conor Lahiff, Petra Goldsmith, Michael Desborough, Katherine S Colman, Richard Guy, Raman Uberoi, Michael F Murphy, James E East, Sally Hopewell, Vipul Jairath
BACKGROUND AND STUDY AIMS:  Investigations for lower gastrointestinal bleeding (LGIB) include flexible sigmoidoscopy, colonoscopy, computed tomographic angiography (CTA), and angiography. All may be used to direct endoscopic, radiological or surgical treatment, although their optimal use is unknown. The aims of this study were to determine the diagnostic and therapeutic yields of endoscopy, CTA, and angiography for managing LGIB, and their influence on rebleeding, transfusion, and hospital stay...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28954046/adenoma-detection-rate-evaluation-and-quality-of-colonoscopy-in-the-center-west-region-of-brazil
#17
Daniela Medeiros Milhomem Cardoso, Marco Aurélio Silveira Botacin, Marilia Adriano Mekdessi
BACKGROUND: Colorectal cancer is the third commonest cancer in men and the second in women worldwide. Peculiarities of its evolution allow secondary prevention measures through colonoscopy, with high diagnostic and therapeutic capacity. In this context, the quality indicators of the procedure become important, among them the adenoma detection rate (ADR). OBJECTIVE: To relate the ADR in a medium risk population subjected to colonoscopy with sociodemographic, technical and histopathological indicators...
September 21, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28944067/intestinal-microbiota-is-altered-in-patients-with-colon-cancer-and-modified-by-probiotic-intervention
#18
Ashley A Hibberd, Anna Lyra, Arthur C Ouwehand, Peter Rolny, Helena Lindegren, Lennart Cedgård, Yvonne Wettergren
OBJECTIVE: The colonic microbiota is altered in patients with colorectal cancer (CRC). We investigated the microbiota composition of patients with colon cancer compared with controls devoid of neoplastic or inflammatory disease and the potential to modify the colonic microbiota with probiotics. DESIGN: Biopsy samples were obtained from the normal mucosa and tumour during colonoscopy from 15 patients with colon cancer. Subsequent patient-matched samples were taken at surgery from the tumour and nearby mucosa from the patients with cancer, eight of whom had received two daily tablets totalling 1...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28932721/clinical-significance-of-preoperative-virtual-colonoscopy-for-evaluation-of-the-proximal-colon-in-patient-with-obstructive-colorectal-cancer
#19
Jae-Hyuk Heo, Chun-Geun Ryu, Eun-Joo Jung, Jin-Hee Paik, Dae-Yong Hwang
PURPOSE: Virtual colonoscopy is the most recently developed tool for detecting colorectal cancers and polyps, but its effectiveness is limited. In our study, we compared the result of preoperative virtual colonoscopy to result of preoperative and postoperative colonoscopy. We evaluated also the accuracy of preoperative virtual colonoscopy in patients who had obstructive colorectal cancer that did not allow passage of a colonoscope. METHODS: A total of 164 patients who had undergone preoperative virtual colonoscopy and curative surgery after the diagnosis of a colorectal adenocarcinoma between November 2008 and August 2013 were pooled...
August 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28924602/factors-defining-expertise-in-screening-colonoscopy
#20
Kinesh Patel, Anna Pinto, Omar Faiz, Matt Rutter, Siwan Thomas-Gibson
BACKGROUND AND STUDY AIMS:  There is very little literature defining characteristics of expert endoscopists. It is hypothesised that previously undetermined human factors may correlate with high performance in screening colonoscopists. The aim of this study was to determine factors contributing towards expertise in screening colonoscopy. MATERIALS AND METHODS:  A focus group was used to hypothesise skills considered to be relevant to high performance in colonoscopy...
September 2017: Endoscopy International Open
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