keyword
MENU ▼
Read by QxMD icon Read
search

BHB

keyword
https://www.readbyqxmd.com/read/29772023/prepartum-supplementation-of-conjugated-linoleic-acids-cla-increased-milk-energy-output-and-decreased-serum-fatty-acids-and-%C3%AE-hydroxybutyrate-in-early-lactation-dairy-cows
#1
Rafael Caputo Oliveira, Ryan S Pralle, Lucas C de Resende, Carlos Henrique P C Nova, Valentina Caprarulo, Joshua A Jendza, Arnulf Troescher, Heather M White
Prepartum supplementation with conjugated linoleic acid (CLA) may influence lipolysis and hyperketonemia in dairy cows. The objective of this study was to examine the effect of prepartum CLA supplementation on lactation performance and serum fatty acids (FA) and β-hydroxybutyrate (BHB) in early lactation dairy cows, and secondarily on reproductive performance. Multiparous cows were enrolled in the study at 18 days prior to expected calving date, and randomly assigned 100 g/day of Lutrell Pure (BASF, Ludwigshafen, Germany; 75% FA), providing 10 g/day of each CLA isomer (trans-10 cis-12 and cis-9 trans-11 CLA) or equivalent amount of rumen inert fatty acids as control (78 g/day of Energy Booster 100; Milk Specialties Global, Eden Prairie, MN)...
2018: PloS One
https://www.readbyqxmd.com/read/29771336/fto-is-a-transcriptional-repressor-to-auto-regulate-its-own-gene-and-potentially-associated-with-homeostasis-of-body-weight
#2
Shu-Jing Liu, Hui-Ling Tang, Qian He, Ping Lu, Tao Fu, Xu-Ling Xu, Tao Su, Mei-Mei Gao, Shumin Duan, Yan Luo, Yue-Sheng Long
Fat mass and obesity-associated (FTO) protein is a ferrous ion (Fe2+)/2-oxoglutarate (2-OG)-dependent demethylase preferentially catalyzing m6A sites in RNA. The FTO gene is highly expressed in the hypothalamus with fluctuation in response to various nutritional conditions, which is believed to be involved in the control of whole body metabolism. However, the underlying mechanism in response to different nutritional cues remains poorly understood. Here we show that ketogenic diet-derived ketone body β-hydroxybutyrate (BHB) transiently increases FTO expression in both mouse hypothalamus and cultured cells...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29748663/direct-neurotransmitter-activation-of-voltage-gated-potassium-channels
#3
Rían W Manville, Maria Papanikolaou, Geoffrey W Abbott
Voltage-gated potassium channels KCNQ2-5 generate the M-current, which controls neuronal excitability. KCNQ2-5 subunits each harbor a high-affinity anticonvulsant drug-binding pocket containing an essential tryptophan (W265 in human KCNQ3) conserved for >500 million years, yet lacking a known physiological function. Here, phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including γ-aminobutyric acid (GABA), which directly activates KCNQ5 and KCNQ3 via W265...
May 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29717378/risk-factors-for-clinical-ketosis-and-association-with-milk-production-and-reproduction-variables-in-dairy-cows-in-a-hot-environment
#4
M Mellado, A Dávila, L Gaytán, U Macías-Cruz, L Avendaño-Reyes, E García
The aims of the present study were to investigate (1) the risk factors that influence the occurrence of clinical ketosis (CK; blood β-hydroxybutyrate > 3.0 mmol/L) and (2) to determine the influence of subclinical ketosis (SCK; 1.2 ≤ β-hydroxybutyrate ≤ 2.9 mmol/L) and CK on reproductive performance and milk yield in high-yielding Holstein cows in a hot environment. Cows (n = 345) were blood sampled from 6 to 15 days postpartum for β-hydroxybutyrate (BHB) determination with a hand-held meter...
May 2, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29716779/effect-of-maternal-metabolism-on-fetal-supply-glucose-non-esterified-fatty-acids-and-beta-hydroxybutyrate-concentrations-in-canine-maternal-serum-and-fetal-fluids-at-term-pregnancy
#5
Orsolya Balogh, Rupert Bruckmaier, Stefanie Keller, Iris Margaret Reichler
The progressive adaptations in carbohydrate and lipid metabolism during canine pregnancy are reflected in the concentrations of glucose, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB). The levels of these metabolites in the bitch likely affect fetal concentrations and the composition of amniotic and allantoic fluids (AMF and ALF, respectively). We studied 31 canine parturitions (Cesarean sections) and found that glucose, NEFA and BHB concentrations were significantly higher in maternal serum than in AMF or ALF...
April 20, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29705430/technical-note-evaluation-of-the-diagnostic-accuracy-of-2-point-of-care-%C3%AE-hydroxybutyrate-devices-in-stored-bovine-plasma-at-room-temperature-and-at-37%C3%A2-c
#6
F A Leal Yepes, D V Nydam, W Heuwieser, S Mann
The use of point-of-care (POC) devices to measure blood metabolites, such as β-hydroxybutyrate (BHB), on farm have become an important diagnostic and screening tool in the modern dairy industry. The POC devices allow for immediate decision making and are often more economical than the use of laboratory-based methods; however, precision and accuracy may be lower when measurements are performed in an uncontrolled environment. Ideally, the advantages of the POC devices and the standardized laboratory environment could be combined when measuring samples that do not require an immediate result-for example, in research applications or when immediate intervention is not the goal...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29705237/b-hydroxybutyrate-protects-from-alcohol-induced-liver-injury-via-a-hcar2-camp-dependent-pathway
#7
Yonglin Chen, Xinshou Ouyang, Rafaz Hoque, Irma Garcia-Martinez, Muhammad Nadeem Yousaf, Sarah Tonack, Stefan Offermanns, Laurent Dubuquoy, Alexandre Louvet, Philippe Mathurin, Veronica Massey, Bernd Schnabl, Ramon A Bataller, Wajahat Zafar Mehal
BACKGROUND & AIMS: Sterile inflammation resulting in alcohol hepatitis (AH) occurs unpredictably after many years of excess alcohol intake. The factors responsible for the development of AH are not known but mitochondrial damage with loss of mitochondrial function are common features. Hcar2 is a G-protein coupled receptor which is activated by β-hydroxybutyrate (BHB), and the relevance of the BHB-Hcar2 pathway in alcoholic liver disease is not known. METHODS: We tested if loss of BHB production can result in increased liver inflammation...
April 26, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29679541/treatment-with-d-%C3%AE-hydroxybutyrate-protects-heart-from-ischemia-reperfusion-injury-in-mice
#8
Yongsheng Yu, Yunhua Yu, Yuefan Zhang, Zhigang Zhang, Weishuai An, Xianxian Zhao
The present study was designed to examine the protection of D-β-hydroxybutyrate (BHB) against ischemia/reperfusion (I/R) injury in heart and investigate its underlying mechanism. Male adult mice were exposed to 30min of ischemia and 24h of reperfusion. Osmotic pumps were implanted subcutaneously 5min before reperfusion for continuous delivery of the exogenous BHB (1.6mmol/kg/24h). Treatment with BHB reduced infarct size and levels of cardiac troponin I, creatine kinase and lactate dehydrogenase in serum, attenuated apoptosis in myocardium, and preserved cardiac function of I/R mice...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29662437/ketogenic-diet-improves-brain-ischemic-tolerance-and-inhibits-nlrp3-inflammasome-activation-by-preventing-drp1-mediated-mitochondrial-fission-and-endoplasmic-reticulum-stress
#9
Min Guo, Xun Wang, Yanxin Zhao, Qi Yang, Hongyan Ding, Qiang Dong, Xingdong Chen, Mei Cui
Background : Neuroprotective effects of ketogenic diets (KD) have been reported in stroke models, and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has also been implicated in the pathogenesis of stroke. This study aimed to investigate the effects of KD on NLRP3 inflammasome and explore the potential molecular mechanisms. Methods : In in vivo study, mice were fed with KD for 3 weeks and then subjected to middle cerebral artery occlusion/reperfusion (MCAO/R)-injury. In in vitro study, SH-SY-5Y cells were treated with β-hydroxybutyrate (BHB) followed by oxygen-glucose deprivation/reoxygenation (OGD/R)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29649104/coordination-of-gpr40-and-ketogenesis-signaling-by-medium-chain-fatty-acids-regulates-beta-cell-function
#10
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E Mitchell, El Hadji M Dioum
Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory factors in the development and progression of the disease. Unlike long chain triglycerides, medium chain triglycerides (MCT) increase fat burning in animal and human subjects as well as serum C-peptide in type 2 diabetes patients. We evaluated the beneficial effects of MCT on β-cells in vivo and in vitro. MCT improved glycemia in aged rats via β-cell function assessed by measuring insulin secretion and content...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29625019/beta-hydroxybutyrate-infusion-identifies-acute-differentially-expressed-genes-related-to-metabolism-and-reproduction-in-the-hypothalamus-and-pituitary-of-sheep
#11
Emily R Cope, Brynn H Voy, Brian K Whitlock, Meg Staton, Thomas Lane, Jack Davitt, J Travis Mulliniks
To identify molecular pathways of metabolic imbalances and reproduction, 10 castrated male sheep were randomly assigned to be injected into the lateral ventricle through intracerebroventricular cannulas with 1 mL of β-hydroxybutyric acid sodium salt solution (BHB; 12,800 µmol/L) or saline solution (CON; 0.9% NaCl). Approximately two hours post injection, sheep were humanely euthanized, and hypothalamus and pituitary tissues were harvested for transcriptome characterization using RNA-sequencing. Ribonucleic acid (RNA) was extracted from the hypothalamus and pituitary and sequenced at a high depth (Hypothalamus: 468,912,732 reads; Pituitary: 515,106,092 reads) using the Illumina Hi-Seq 2500 platform and aligned to Bos taurus and Ovis aries genomes...
April 6, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29617370/metabolic-and-hormonal-adaptation-in-bubalus-bubalis-around-calving-and-early-lactation
#12
Enrico Fiore, Francesca Arfuso, Matteo Gianesella, Domenico Vecchio, Massimo Morgante, Elisa Mazzotta, Tamara Badon, Pasquale Rossi, Silvia Bedin, Giuseppe Piccione
Pregnancy and lactation are physiological periods that result in an increased metabolic demand that, if not satisfied, could provoke a threat to homeostasis. In this study changes in the values of Non-Esterified Fatty Acids (NEFA) and β-hydroxybutyrate (BHB), glucose, insulin, thyroid hormones, milk composition and yield were investigated in buffaloes during the late pregnancy and early lactation. From a total of 50 buffaloes, blood samples were collected -7±5 days before expected calving; +7±5; +30±5 and +50±5 days post-partum; milk samples were collected at the same post-partum time points...
2018: PloS One
https://www.readbyqxmd.com/read/29607218/nutritional-ketosis-and-mitohormesis-potential-implications-for-mitochondrial-function-and-human-health
#13
REVIEW
Vincent J Miller, Frederick A Villamena, Jeff S Volek
Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diabetes, neurodegenerative disorders, and cancer. Moderate levels of mitochondrial ROS, however, can protect against chronic disease by inducing upregulation of mitochondrial capacity and endogenous antioxidant defense. This phenomenon, referred to as mitohormesis, is induced through increased reliance on mitochondrial respiration, which can occur through diet or exercise...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29588960/the-relationship-between-d-beta-hydroxybutyrate-blood-concentrations-and-seizure-control-in-children-treated-with-the-ketogenic-diet-for-medically-intractable-epilepsy
#14
Jeffrey R Buchhalter, Sabrina D'Alfonso, Mary Connolly, Ernest Fung, Aspasia Michoulas, David Sinasac, Rachel Singer, Jacklyn Smith, Narender Singh, Jong M Rho
Objective: The ketogenic diet (KD) is a proven treatment for drug-resistant (DR) seizures in children and adolescents. However, the relationship between seizure control and the most commonly measured metabolite of the diet, the ketone body d-beta-hydroxybutyrate (D-BHB), is controversial. This study was performed to clarify the relationship because specific ketone bodies may be useful as biomarkers of diet efficacy. Methods: Families of children with DR seizures were approached for participation in this open-label, prospective study when they were referred for the KD at two western Canadian children's hospitals...
September 2017: Epilepsia open
https://www.readbyqxmd.com/read/29566529/heterogeneous-nucleation-of-a-droplet-pinned-at-a-chemically-inhomogeneous-substrate-a-simulation-study-of-the-two-dimensional-ising-case
#15
Marta L Trobo, Ezequiel V Albano, Kurt Binder
Heterogeneous nucleation is studied by Monte Carlo simulations and phenomenological theory, using the two-dimensional lattice gas model with suitable boundary fields. A chemical inhomogeneity of length b at one boundary favors the liquid phase, while elsewhere the vapor is favored. Switching on the bulk field Hb favoring the liquid, nucleation and growth of the liquid phase starting from the region of the chemical inhomogeneity are analyzed. Three regimes occur: for small fields, Hb <Hb crit , the critical droplet radius is so large that a critical droplet having the contact angle θc required by Young's equation in the region of the chemical inhomogeneity does not yet "fit" there since the baseline length of the circle-cut sphere droplet would exceed b...
March 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29536468/-management-of-the-dry-and-transition-periods-of-dairy-cattle-in-free-stall-housing-systems-in-lower-saxony-part-2-risk-factores-for-subclinical-ketosis-hypocalcaemia-and-increased-lipomobilisation
#16
Pamela Oetting-Neumann, Karl Rohn, Martina Hoedemaker
OBJECTIVE: Determination of the frequency of subclinical hypocalcaemia, increased lipomobilisation and subclinical ketosis as problems in dairy herds and identification of possible risk factors. MATERIAL AND METHODS: Information was obtained from 51 dairy farms on husbandry, feeding, management of the cows and heifers, animal health and prophylactic treatments using a questionnaire. Blood samples from 20% of the cows and 30% of the heifers of each farm (= herd sample) were collected in the week ante partum (a...
February 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29518709/metabolic-predictors-of-peri-partum-diseases-and-their-association-with-parity-in-dairy-cows
#17
Gretel Ruprechter, Maria de Lourdes Adrien, Alejandro Larriestra, Otavio Meotti, Chester Batista, Ana Meikle, Mirela Noro
The predictive values of plasma non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), cholesterol, albumin and calcium to predict risk of peripartum diseases in primiparous (PP) and multiparous (MP) Holstein cows was investigated. Besides it was assessed if the health status interacted with parity on body condition score and metabolic profiles during the transition period. Dairy cows (126 PP and 182 MP) from a commercial dairy free stall herd (loose-housing system) were weekly body condition scored and tail bled for metabolites determination from -3 to +4 weeks relative to calving...
February 19, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29513157/use-of-lispro-insulin-for-treatment-of-diabetic-ketoacidosis-in-cats
#18
Eleonora Malerba, Michela Mazzarino, Francesca Del Baldo, Sara Corradini, Gaia Carotenuto, Massimo Giunti, Federico Fracassi
Objectives The aim of this study was to evaluate the efficacy and safety of lispro insulin for the treatment of feline diabetic ketoacidosis (DKA). Times to resolution of hyperglycaemia, ketosis and acidosis were compared between cats treated with continuous rate infusion (CRI) of lispro insulin and cats treated with CRI of regular insulin. Methods Client-owned cats with naturally occurring DKA, newly diagnosed with diabetes mellitus (DM) or already receiving treatment for DM, were included. Diagnosis of DKA involved the presence of at least two clinical signs consistent with DKA (eg, polyuria/polydipsia, anorexia, severe lethargy, vomiting and dehydration), blood glucose (BG) concentration >13...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29501182/preparation-of-ionic-liquid-modified-magnetic-metal-organic-frameworks-composites-for-the-solid-phase-extraction-of-%C3%AE-chymotrypsin
#19
Xiaoxiao Wei, Yuzhi Wang, Jing Chen, Panli Xu, Yigang Zhou
A novel magnetic solid-phase extraction (MSPE) method based on 1-hexyl-3-methyl imidazolium chloride ionic liquid (IL) modified magnetic Fe3 O4 nanoparticles, hydroxylated multiwall carbon nanotubes (MWCNTs-OH) and zeolitic imidazolate frameworks (ZIFs) nanocomposites (Fe3 O4 -MWCNTs-OH@ZIF-67@IL) were proposed and applied to extract α-chymotrypsin. The magnetic materials were synthesized successfully and characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), thermal gravimetric analysis (TGA), fourier transform infrared spectrometry (FT-IR), vibrating sample magnetometer (VSM) and zeta potentials...
May 15, 2018: Talanta
https://www.readbyqxmd.com/read/29477527/a-randomized-controlled-trial-on-the-effect-of-incomplete-milking-during-early-lactation-on-ketonemia-and-body-condition-loss-in-holstein-dairy-cows
#20
P-A Morin, C Krug, Y Chorfi, J Dubuc, P Lacasse, J-P Roy, D E Santschi, S Dufour
Limiting milk production for a short period of time in early lactation could be a relevant strategy to prevent hyperketonemia (HYK). From December 2013 to March 2015, 838 multiparous Holstein cows from 13 herds were enrolled in a randomized controlled trial evaluating the effect of incomplete milking in early lactation on ketonemia and its effect on body condition score (BCS) loss. Cows were randomly assigned 4 wk before expected calving date to 1 of 2 treatment groups, (1) a conventional milking protocol (CON) for which cows were completely milked or (2) an incomplete milking protocol (INC) for which a maximum of 10 to 14 kg of milk/d were withdrawn during the first 5 d in milk (DIM)...
May 2018: Journal of Dairy Science
keyword
keyword
62333
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"