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https://www.readbyqxmd.com/read/28608588/experimental-and-computational-characterization-on-the-binding-of-two-fluoroquinolones-to-bovine-hemoglobin
#1
Pengfei Qin, Xingren Pan, Rutao Liu, Jicai Qiu, Xiaoyan Fang
Ciprofloxacin (CPFX) and enrofloxacin (ENFX) are 2 representatives of widely used fluoroquinolones (FQs) with many human and veterinary applications. The residues of FQs in the environment are potentially harmful. Recently, great concern has been paid to their persistence and fate in the environment because of the potential adverse effects on humans and ecosystem functions. In the present study, we examined the interactions of bovine hemoglobin (BHb) with these 2 FQs by means of multiple spectroscopic and molecular docking methods under physiological conditions...
June 13, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28604271/the-study-on-interactions-between-levofloxacin-and-model-proteins-by-using-multi-spectroscopic-and-molecular-docking-methods
#2
Qing Fang, Chenhui Guo, Yirun Wang, Ying Liu
The interactions of levofloxacin (LEV) with lysozyme (LYZ), trypsin and bovine hemoglobin (BHb) were investigated, respectively by using multi-spectral techniques and molecular docking in vitro. Fluorescence studies showed that LEV quenched LYZ/trypsin fluorescence in a combined quenching ways and BHb fluorescence in a static quenching with binding constants of 0.14, 0.51 and 0.20 × 10(5) L⋅mol(-1) at 298 K, respectively. The thermodynamic parameters demonstrated that hydrophobic forces, hydrogen bonds and van der Waals forces played the major role in the binding process...
June 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28597971/diagnosis-of-congenital-hyperinsulinism-biochemical-profiles-during-hypoglycemia
#3
Azumi Sakakibara, Yukiko Hashimoto, Rie Kawakita, Yuki Hosokawa, Keiko Nagahara, Yukihiro Hasegawa, Shin Hoshino, Hironori Nagasaka, Tohru Yorifuji
OBJECTIVES: To define the ranges of biochemical markers during hypoglycemia for the diagnosis of congenital hyperinsulinism (CHI), using high sensitivity insulin assays. SUBJECTS: A total of 298 patients with CHI and 58 control patients with non-hyperinsulinemic hypoglycemia, who were diagnosed after 2007. METHODS: The levels of biochemical markers (glucose, insulin, β-hydroxybutyrate [BHB], free fatty acids [FFA], lactate, ammonia) at the time of hypoglycemia were analyzed along with the maximal glucose infusion rate (GIR) to maintain euglycemia and clinical outcomes...
June 9, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28583851/%C3%AE-hydroxybutyrate-alleviates-depressive-behaviors-in-mice-possibly-by-increasing-the-histone3-lysine9-%C3%AE-hydroxybutyrylation
#4
Li Chen, Zhigang Miao, Xingshun Xu
Epigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by β-hydroxybutyrate, may participate in the development of depression. To uncover the role of H3k9bhb in depression, experiments were performed on mice and cells. Endogenous β-hydroxybutyrate and H3k9bhb were reduced in brain of depressive mouse models...
June 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28571993/genetic-parameters-of-blood-%C3%AE-hydroxybutyrate-predicted-from-milk-infrared-spectra-and-clinical-ketosis-and-their-associations-with-milk-production-traits-in-norwegian-red-cows
#5
T K Belay, M Svendsen, Z M Kowalski, T Ådnøy
The aim of this study was to estimate genetic parameters for blood β-hydroxybutyrate (BHB) predicted from milk spectra and for clinical ketosis (KET), and to examine genetic association of blood BHB with KET and milk production traits (milk, fat, protein, and lactose yields, and milk fat, protein, and lactose contents). Data on milk traits, KET, and milk spectra were obtained from the Norwegian Dairy Herd Recording System with legal permission from TINE SA (Ås, Norway), the Norwegian Dairy Association that manages the central database...
May 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28571989/an-attempt-at-predicting-blood-%C3%AE-hydroxybutyrate-from-fourier-transform-mid-infrared-spectra-of-milk-using-multivariate-mixed-models-in-polish-dairy-cattle
#6
T K Belay, B S Dagnachew, Z M Kowalski, T Ådnøy
Fourier transform mid-infrared (FT-MIR) spectra of milk are commonly used for phenotyping of traits of interest through links developed between the traits and milk FT-MIR spectra. Predicted traits are then used in genetic analysis for ultimate phenotypic prediction using a single-trait mixed model that account for cows' circumstances at a given test day. Here, this approach is referred to as indirect prediction (IP). Alternatively, FT-MIR spectral variable can be kept multivariate in the form of factor scores in REML and BLUP analyses...
May 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551194/effects-of-shortening-the-close-up-period-length-coupled-with-increased-supply-of-metabolizable-protein-on-performance-and-metabolic-status-of-multiparous-holstein-cows
#7
T Amirabadi Farahani, H Amanlou, M Kazemi-Bonchenari
This experiment was conducted to compare conventional (CON; 21 d) and shortened (SH; 10 d) close-up period, and evaluate the effect of shortened close-up period combined with feeding different metabolizable protein (MP) levels on dry matter (DM) intake, metabolic status, and performance of dairy cows. Forty-eight multiparous Holstein cows with similar parity, body weight (BW), and previous lactation milk yield were divided into 2 groups. The first group (n = 24) received the far-off diet from -60 to -21 d (CON), and the second group (n = 24) received same far-off diet from -60 to -10 d (SH) relative to expected parturition...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28551184/the-effect-of-different-treatments-for-early-lactation-hyperketonemia-on-blood-%C3%AE-hydroxybutyrate-plasma-nonesterified-fatty-acids-glucose-insulin-and-glucagon-in-dairy-cattle
#8
S Mann, F A Leal Yepes, E Behling-Kelly, J A A McArt
Despite increased efforts in preventing the occurrence of metabolic disorders in transition cows, hyperketonemia remains a frequent early-lactation metabolic disease affecting an average of 40% of cows in herds in the United States. Despite the demonstrated economic effect of this disorder, controlled clinical trials comparing different treatment strategies in affected cows are lacking. The objective of our study was to investigate the effect of treatment with intravenous glucose, oral propylene glycol, or a combination of both on the reduction in blood β-hydroxybutyrate (BHB) concentrations of early-lactation hyperketonemic dairy cows...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28508489/prediction-of-whole-genome-risk-for-selection-and-management-of-hyperketonemia-in-holstein-dairy-cattle
#9
K A Weigel, R S Pralle, H Adams, K Cho, C Do, H M White
Hyperketonemia (HYK), a common early postpartum health disorder characterized by elevated blood concentrations of β-hydroxybutyrate (BHB), affects millions of dairy cows worldwide and leads to significant economic losses and animal welfare concerns. In this study, blood concentrations of BHB were assessed for 1,453 Holstein cows using electronic handheld meters at four time points between 5 and 18 days postpartum. Incidence rates of subclinical (1.2 ≤ maximum BHB ≤ 2.9 mmol/L) and clinical ketosis (maximum BHB ≥ 3...
June 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28504317/adrenal-cortex-reactivity-in-dairy-cows-differs-between-lactational-stages-and-between-different-feeding-levels
#10
J J Gross, R S Zbinden, F Dohme-Meier, R M Bruckmaier
Changes in ACTH challenge test characteristics in dairy cows changing their physiological status at different lactational stages and different feeding levels were not investigated in terms of repeatability yet. In 23 multiparous Holstein cows (10 cows fed a sole fresh herbage diet without concentrate, 13 cows fed with concentrate), three ACTH challenge tests were performed: once during pregnancy shortly prior to drying off (T1), and in week 3 (T2) and 8 (T3) after parturition. Test characteristics were correlated to performance and metabolic parameters: DMI, BW, energy balance (EB), plasma concentrations of free fatty acids (NEFA) and beta-hydroxybutyrate (BHB)...
May 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28501411/short-communication-associations-between-blood-glucose-concentration-onset-of-hyperketonemia-and-milk-production-in-early-lactation-dairy-cows
#11
J Ruoff, S Borchardt, W Heuwieser
The objectives of this study were to describe the associations between hypoglycemia and the onset of hyperketonemia (HYK) within the first 6 wk of lactation, to evaluate the effects of body condition score at calving on glucose concentration, and to study the effects of hypoglycemia on milk production. A total of 621 dairy cows from 6 commercial dairy farms in Germany were enrolled between 1 and 4 d in milk (DIM). Cows were tested twice weekly using an electronic handheld meter for glucose and β-hydroxybutyrate (BHB), respectively, for a period of 42 d...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28489728/novel-adjunct-drugs-reverse-endothelial-glycocalyx-damage-after-hemorrhagic-shock-in-rats
#12
Ivo P Torres Filho, Luciana N Torres, Christi Salgado, Michael A Dubick
INTRODUCTION: There is interest in the small-volume therapeutic use of adjunct drugs for treating hemorrhagic shock (HS). However, critical information is only partially available on mechanisms of action of promising compounds such as adenosine-lidocaine-Magnesium (ALM), beta-hydroxybutyrate plus melatonin (BHB/M), and poloxamer 188 (P-188). Therefore, we tested the hypothesis that these adjuncts would reverse HS-induced damage to microvascular endothelial glycocalyx and hemodynamics...
May 9, 2017: Shock
https://www.readbyqxmd.com/read/28485837/characterization-of-the-analytic-performance-of-an-electrochemical-point-of-care-meter-for-measuring-%C3%AE-hydroxybutyrate-concentration-in-blood-and-plasma-from-periparturient-dairy-cattle
#13
Ameer A Megahed, Mark W H Hiew, Jonathan R Townsend, Peter D Constable
BACKGROUND: The Precision Xtra electrochemical meter is widely used to measure blood β-hydroxybutyrate concentration (BHBb) in dairy cattle. The meter uses an algorithm optimized for human blood that assumes the HCT in cattle is the same as in people, and that intra-erythrocyte β-hydroxybutyrate (BHBe) and plasma β-hydroxybutyrate (BHBp) concentration are equivalent. OBJECTIVES: The first objective was to characterize the analytic performance of the meter for measuring BHBb and BHBp in dairy cattle...
June 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28464111/circulating-beta-hydroxybutyrate-concentration-may-be-a-predictive-measurement-for-young-cows-that-have-a-greater-probability-to-conceive-at-a-fixed-time-artificial-insemination
#14
J D Hobbs, S R Edwards, E R Cope, Z D McFarlane, K G Pohler, J T Mulliniks
Timing of conception, which has been indicated to be negatively influenced by metabolic dysfunctions, can influence lifetime productivity within the cow herd. Therefore, our objective was to analyze the association of milk production, serum metabolites as an indicator of nutrient status, cow BW and BW change, and calf BW with timing of pregnancy in 183 spring-calving beef cows. Cows were retrospectively classified by timing of pregnancy as cows that were diagnosed pregnant by timed AI (TAI; = 118) or natural breeding (NAT; = 65)...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28457547/the-effect-of-dry-period-length-and-postpartum-level-of-concentrate-on-milk-production-energy-balance-and-plasma-metabolites-of-dairy-cows-across-the-dry-period-and-in-early-lactation
#15
R J van Hoeij, J Dijkstra, R M Bruckmaier, J J Gross, T J G M Lam, G J Remmelink, B Kemp, A T M van Knegsel
Shortening or omitting the dry period (DP) improves energy balance (EB) in early lactation because of a reduction in milk yield. Lower milk yield results in lower energy demands and requires less energy intake. The aim of this study was to evaluate the effects of DP length and concentrate level postpartum on milk yield, feed intake, EB, and plasma metabolites between wk -4 and 7 relative to calving of cows of second parity or higher. Holstein-Friesian dairy cows (n = 123) were assigned randomly to 1 of 2 DP lengths: 0-d DP (n = 81) or 30-d DP (n = 42)...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28419943/interconnectivity-of-macroporous-molecularly-imprinted-polymers-fabricated-by-hydroxyapatite-stabilized-pickering-high-internal-phase-emulsions-hydrogels-for-the-selective-recognition-of-protein
#16
Yanhua Sun, Yuqing Li, Jiangfeng Xu, Ling Huang, Tianyun Qiu, Shian Zhong
Hydroxyapatite hybridized molecularly imprinted polydopamine polymers with selective recognition of bovine hemoglobin (BHb) were successfully prepared via Pickering oil-in-water high internal phase emulsions-hydrogels and molecularly imprinting technique. The emulsions were stabilized by hydroxyapatite of which the wettability was modified by 3-methacryloxypropyltrimethoxysilane. The materials were characterized by SEM, IR and TGA. The results showed that the BHb imprinted polymers based on Pickering hydrogels (Hydro-MIPs) possess macropores ranging from 20μm to 50μm, and their large numbers of amino groups and hydroxyl groups result in a favorable adsorption capacity for BHb...
April 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28397627/influence-of-fumaric-acid-on-ruminal-parameters-and-organ-weights-of-growing-bulls-fed-with-grass-or-maize-silage
#17
N Remling, S Riede, U Meyer, A Beineke, G Breves, G Flachowsky, S Dänicke
The influence of the potential methane reducer, fumaric acid (FA), on ruminal parameters, the rumen wall and organ weights was investigated in a long-term study with growing bulls. In all, 20 bulls were fed with maize or grass silage as roughage, and with concentrate with or without 300 g FA per animal and day during the whole fattening period. After slaughtering, the organs were weighed and blood serum was analysed for glucose, β-hydroxybutyric acid (BHB) and non-esterified fatty acid concentration. The ruminal fluid was analysed for short-chain fatty acids, ammonia-N and the microbial community via single strand conformation polymorphism analysis...
April 11, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28397070/ketone-bodies-as-anti-seizure-agents
#18
Timothy A Simeone, Kristina A Simeone, Jong M Rho
There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced and spontaneous recurrent seizures in various animal models. Although the mechanisms underlying the anti-seizure effects of KB have not been fully elucidated, recent experimental studies have invoked ketone-mediated effects on both inhibitory (e...
April 10, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28355243/ketogenic-diet-improves-the-spatial-memory-impairment-caused-by-exposure-to-hypobaric-hypoxia-through-increased-acetylation-of-histones-in-rats
#19
Ming Zhao, Xin Huang, Xiang Cheng, Xiao Lin, Tong Zhao, Liying Wu, Xiaodan Yu, Kuiwu Wu, Ming Fan, Lingling Zhu
Exposure to hypobaric hypoxia causes neuron cell damage, resulting in impaired cognitive function. Effective interventions to antagonize hypobaric hypoxia-induced memory impairment are in urgent need. Ketogenic diet (KD) has been successfully used to treat drug-resistant epilepsy and improves cognitive behaviors in epilepsy patients and other pathophysiological animal models. In the present study, we aimed to explore the potential beneficial effects of a KD on memory impairment caused by hypobaric hypoxia and the underlying possible mechanisms...
2017: PloS One
https://www.readbyqxmd.com/read/28346669/evaluation-of-a-point-of-care-electrochemical-meter-to-detect-subclinical-ketosis-and-hypoglycaemia-in-lactating-dairy-cows
#20
COMPARATIVE STUDY
A Zakian, M Tehrani-Sharif, M R Mokhber-Dezfouli, M Nouri, P D Constable
OBJECTIVES: To evaluate and validate a hand-held electrochemical meter (Precision Xtra®) as a screening test for subclinical ketosis and hypoglycaemia in lactating dairy cattle. DESIGN: Method comparison study using a convenience sample. PROCEDURE: Blood samples were collected into plain tubes from the coccygeal vessels of 181 Holstein cows at 2-4 weeks of lactation during summer in Iran. Blood β-hydroxybutyrate concentration (BHB) and glucose concentration were immediately measured by the electrochemical meter after applying 20 μL of blood to the reagent strip...
April 2017: Australian Veterinary Journal
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