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https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#1
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677369/targeted-drug-delivery-in-the-suprachoroidal-space-by-swollen-hydrogel-pushing
#2
Jae Hwan Jung, Patcharin Desit, Mark R Prausnitz
Purpose: The purpose is to target model drug particles to the posterior region of the suprachoroidal space (SCS) of the eye controlled via pushing by hydrogel swelling. Methods: A particle formulation containing 1% hyaluronic acid (HA) with fluorescent polymer particles and a hydrogel formulation containing 4% HA were introduced in a single syringe as two layers without mixing, and injected sequentially into the SCS of the rabbit eye ex vivo and in vivo using a microneedle...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677140/flow-channel-influence-of-a-collision-based-piezoelectric-jetting-dispenser-on-jet-performance
#3
Can Zhou, Guiling Deng, Junhui Li, Ji'an Duan
To improve the jet performance of a bi-piezoelectric jet dispenser, mathematical and simulation models were established according to the operating principle. In order to improve the accuracy and reliability of the simulation calculation, a viscosity model of the fluid was fitted to a fifth-order function with shear rate based on rheological test data, and the needle displacement model was fitted to a nine-order function with time based on real-time displacement test data. The results show that jet performance is related to the diameter of the nozzle outlet and the cone angle of the nozzle, and the impacts of the flow channel structure were confirmed...
April 20, 2018: Sensors
https://www.readbyqxmd.com/read/29677134/modeling-skin-injury-from-hot-rice-porridge-spills
#4
Torgrim Log
The present work analyzes skin burns from spills of hot rice and milk products. The traditional Norwegian rice porridge serves as an example. By testing spills on objects emulating an arm, it was concluded that spills were seldom thinner than 3 mm, and stayed in place due to the viscosity of the porridge for more than one minute. The Pennes bioheat equation was solved numerically for such spills, including heat conduction to the skin and convective heat losses from the porridge surface. Temperatures were analyzed in the porridge and skin layers, and the resulting skin injury was calculated based on the basal layer temperature...
April 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29676980/effect-of-bleaching-gel-viscosity-on-tooth-whitening-efficacy-and-pulp-chamber-penetration-an-in-vitro-study
#5
S R Kwon, Fnu Pallavi, Y Shi, U Oyoyo, A Mohraz, Y Li
OBJECTIVES: Whitening efficacy has been related to hydrogen peroxide (HP) diffusion into tooth structure. However, little information is available relating rheological properties to whitening efficacy. The purpose was to evaluate the whitening efficacy and HP penetration level of a 10% HP gel at three different viscosities and to compare them to a strip delivery system. METHODS AND MATERIALS: Extracted molars (n=120) were randomly assigned into five groups (n=24/ group): NC_MED (negative control; median): medium viscosity gel without HP; LOW: 10% HP gel (low viscosity experimental gel, Ultradent Products Inc); MED: 10% HP gel (medium viscosity experimental gel, Ultradent); HIGH: 10% HP gel (high viscosity gel, Ultradent); and CWS: Crest 3D Whitestrips 1-Hour Express (Procter & Gamble)...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676140/-effect-of-shenqi-dihuang-decoction-on-inflammatory-factor-renal-function-and-microcirculation-in-patients-with-early-diabetic-nephropathy
#6
Ming-Rui Wang, Li-Hua Yu, Ting-Ting Wang, Ye-Mei Wang, Ming-Xiang Han
To study the effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy. A total of 205 cases of patient with early diabetic nephropathy treated in our hospital from March 2014 to April 2016 were selected and divided into two groups according to the admitted order, with 103 cases in clinical group and 102 in control group. Patients in control group were treated with melbine and captopril, which may be adjusted according to the clinical symptom...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676119/-optimize-preparation-of-compound-licorice-microemulsion-with-d-optimal-design
#7
Shu-Wei Ma, Yong-Jie Wang, Cheng Chen, Yue Qiu, Qing Wu
In order to increase the solubility of essential oil in compound licorice microemulsion and improve the efficacy of the decoction for treating chronic eczema, this experiment intends to prepare the decoction into microemulsion. The essential oil was used as the oil phase of the microemulsion and the extract was used as the water phase. Then the microemulsion area and maximum ratio of water capacity was obtained by plotting pseudo-ternary phase diagram, to determine the appropriate types of surfactant and cosurfactant, and Km value-the mass ratio between surfactant and cosurfactant...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675225/a-new-twist-in-the-photophysics-of-the-gfp-chromophore-a-volume-conserving-molecular-torsion-couple
#8
Jamie Conyard, Ismael A Heisler, Yohan Chan, Philip C Bulman Page, Stephen R Meech, Lluís Blancafort
The simple structure of the chromophore of the green fluorescent protein (GFP), a phenol and an imidazolone ring linked by a methyne bridge, supports an exceptionally diverse range of excited state phenomena. Here we describe experimentally and theoretically the photochemistry of a novel sterically crowded nonplanar derivative of the GFP chromophore. It undergoes an excited state isomerization reaction accompanied by an exceptionally fast (sub 100 fs) excited state decay. The decay dynamics are essentially independent of solvent polarity and viscosity...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674976/neocytolysis-how-to-get-rid-of-the-extra-erythrocytes-formed-by-stress-erythropoiesis-upon-descent-from-high-altitude
#9
REVIEW
Heimo Mairbäurl
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of erythrocytes and hemoglobin (Hb) when it is not required anymore and to decrease blood viscosity. Neocytolysis seems to occur upon descent from high altitude. Similar processes seem to occur in microgravity, and are also discussed to mediate the replacement of erythrocytes containing fetal hemoglobin (HbF) with those having adult hemoglobin (HbA) after birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674056/evaluation-of-11-ionic-liquids-as-potential-extraction-solvents-for-benzodiazepines-from-whole-blood-using-liquid-liquid-microextraction-combined-with-lc-ms-ms
#10
Marieke De Boeck, Giacomo Damilano, Wim Dehaen, Jan Tytgat, Eva Cuypers
Ionic liquids (ILs) are becoming a trending topic in sample preparation technology, due to their low volatility, low flammability and tunable physiochemical properties. The latter affords the opportunity for creating task-specific solvents. In toxicology, these tailored ILs were not introduced yet; however, they can be significant for drug extraction purposes. This study screens 11 commercially available ILs as potential extraction media for benzodiazepines from blood samples via liquid-liquid microextraction, coupled to liquid chromatography - tandem mass spectrometry (LC-MS/MS)...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673957/carboxymethyl-fenugreek-gum-rheological-characterization-and-as-a-novel-binder-for-silicon-anode-of-lithium-ion-batteries
#11
Liewei Qiu, Yiding Shen, Huabo Fan, Xiaowu Yang, Chen Wang
The rheology of carboxymethyl fenugreek gum (CFG) is characterized and applied it as a binder for the silicon anode of lithium-ion batteries (LIBs). First, a series of carboxymethyl fenugreek gum (namely CFG-1, CFG-2 and CFG-3) was prepared and characterized by Fourier transform infrared spectrophotometer and hydrogen nuclear magnetic resonance spectrometry studies. In rheological measurements, the CFG solutions show higher flowability, weaker viscoelastic behavior and better thixotropy than that of fenugreek gum (FG) solution...
April 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29673936/comparison-between-a-generalized-newtonian-model-and-a-network-type-multiscale-model-for-hemodynamic-behavior-in-the-aortic-arch-validation-with-4d-mri-data-for-a-case-study
#12
Marine Menut, Loïc Boussel, Xavier Escriva, Benyebka Bou-Saïd, Hélène Walter-Le Berre, Yann Marchesse, Antoine Millon, Nellie Della Schiava, Patrick Lermusiaux, John Tichy
Blood is a complex fluid in which the presence of the various constituents leads to significant changes in its rheological properties. Thus, an appropriate non-Newtonian model is advisable; and we choose a Modified version of the rheological model of Phan-Thien and Tanner (MPTT). The different parameters of this model, derived from the rheology of polymers, allow characterization of the non-Newtonian nature of blood, taking into account the behavior of red blood cells in plasma. Using the MPTT model that we implemented in the open access software OpenFOAM, numerical simulations have been performed on blood flow in the thoracic aorta for a healthy patient...
March 29, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29673709/evaluation-of-the-filler-packing-structures-in-dental-resin-composites-from-theory-to-practice
#13
Ruili Wang, Eric Habib, X X Zhu
OBJECTIVES: The aim of this study is to evaluate the packing properties of uniform silica particles and their mixture with secondary particles yielding maximally loaded dental composites. We intend to verify the difference between the idealized models (the close-packed structures and the random-packed structures) and the actual experimental results, in order to provide guidance for the preparation of dental composites. The influence of secondary particle size and the resin composition on the physical-mechanical properties and the rheological properties of the experimental dental composites was also investigated...
April 16, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29673153/pectin-from-citrus-canning-wastewater-as-potential-fat-replacer-in-ice-cream
#14
Hua Zhang, Jianle Chen, Junhui Li, Chaoyang Wei, Xingqian Ye, John Shi, Shiguo Chen
Pectin had been recovered from canning wastewater produced by chemical treatment of segment membrane during preparation of canned citrus in our previous research. The purpose of this study was to characterize the extracted pectin from canning wastewater, and to evaluate its application as a fat alternative to replace fat in ice cream. The monosaccharide composition and rheological properties of the pectin were determined. The influences of fat reduction and pectin addition on the physicochemical, rheological and sensory properties of low-fat ice cream were determined...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29672247/management-of-chronic-hypotony-following-bilateral-uveitis-in-a-patient-treated-with-pembrolizumab-for-cutaneous-metastatic-melanoma
#15
Gerard Reid, Paul Lorigan, Heinrich Heimann, Marta Hovan
PURPOSE: To describe the presentation and management of severe ocular adverse events following treatment with pembrolizumab for cutaneous metastatic melanoma. METHODS: Interventional case report. RESULTS: A 73-year-old Caucasian man receiving pembrolizumab treatment for metastatic melanoma presented with panuveitis and subsequent profound hypotony, choroidal effusions, and optic disk swelling bilaterally. Oral prednisolone controlled intraocular inflammation...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29670944/shaken-and-stirred-random-organization-reduces-viscosity-and-dissipation-in-granular-suspensions
#16
Christopher Ness, Romain Mari, Michael E Cates
The viscosity of suspensions of large (≥10 μm) particles diverges at high solid fractions due to proliferation of frictional particle contacts. Reducing friction, to allow or improve flowability, is usually achieved by tuning the composition, either by changing particle sizes and shapes or by adding lubricating molecules. We present numerical simulations that demonstrate a complementary approach whereby the viscosity divergence is shifted by driven flow tuning, using superimposed shear oscillations in various configurations to facilitate a primary flow...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29670336/transethosomal-gels-as-carriers-for-the-transdermal-delivery-of-colchicine-statistical-optimization-characterization-and-ex-vivo-evaluation
#17
Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan
Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. Its oral administration is associated with poor bioavailability and severe gastrointestinal side effects. The drug is also known to have a low therapeutic index. Thus to overcome these drawbacks, the transdermal delivery of colchicine was investigated using transethosomal gels as potential carriers. Methods: Colchicine-loaded transethosomes (TEs) were prepared by the cold method and statistically optimized using three sets of 24 factorial design experiments...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29670246/slow-slip-events-in-semi-brittle-serpentinite-fault-zones
#18
A Goswami, S Barbot
Slow-slip events are earthquake-like events only with much lower slip rates. While peak coseismic velocities can reach tens of meters per second, slow-slip is on the order of 10-7±2 m/s and may last for days to weeks. Under the rate-and-state model of fault friction, slow-slip is produced only when the asperity size is commensurate with the critical nucleation size, a function of frictional properties. However, it is unlikely that all subduction zones embody the same frictional properties. In addition to friction, plastic flow of antigorite-rich serpentinite may significantly influence the dynamics of fault slip near the mantle wedge corner...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669437/development-of-hydrogels-oleogels-and-bigels-as-local-drug-delivery-systems-for-periodontitis
#19
Rania Hamed, Ala'a AbuRezeq, Ola Tarawneh
Periodontal disease is a chronic inflammation of gum and tissues that surround and support the teeth. Nonsteroidal anti-inflammatory drugs (NSAIDs) can be used in the treatment of periodontitis to ease swelling and inflammation. One approach of treating periodontitis is loading the NSAIDs in local drug delivery systems. Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel)...
April 19, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29668278/combining-freezing-point-depression-and-self-diffusion-data-for-characterizing-aggregation
#20
Markus M Hoffmann, Sarah Bothe, Torsten Gutmann, Gerd Buntkowsky
The colligative property freezing point depression is evaluated as a means for estimating the extent of aggregation for solutions of poly(ethylene oxide) alcohol (C10E6) nonionic surfactant in cyclohexane. Combined with additional measurements of self-diffusion coefficients, it is shown that both un-aggregated C10E6 as well as reverse micelles are significantly present for the entire range of measured C10E6 concentration (0.048 mol·kg-1 - 2.35 mol·kg-1). A change in speciation near 0.2 mol·kg-1 is indicated by both the results from freezing point depression and self-diffusion coefficients measurements...
April 18, 2018: Journal of Physical Chemistry. B
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