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https://www.readbyqxmd.com/read/29458206/mucoadhesive-self-emulsifying-delivery-systems-for-ocular-administration-of-econazole
#1
Ibrahim A Elbahwy, Noemi Lupo, Hany M Ibrahim, Hatem R Ismael, Alaa A Kasem, Cagri Caliskan, Barbara Matuszczak, Andreas Bernkop-Schnürch
AIM: Development of mucoadhesive self-emulsifying drug delivery systems (SEDDS) providing a prolonged ocular residence time for poorly soluble active pharmaceutical ingredient. METHODS: L-Cysteine was covalently linked to 6-mercaptonicotinamide. The obtained ligand, Cysteine-6- mercaptonicotinamide (Cys-6-MNA) was attached to Eudragit® L100-55 via a carbodiimide mediated amide bond formation. The resulting entirely S-protected thiolated Eudragit® L100-55 was characterized regarding the degree of modification as well as stability toward oxidation in the presence of strong oxidizing agent (H2 O2 )...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#2
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458006/mechanistic-studies-of-formate-oxidase-from-aspergillus-oryzae-a-novel-member-of-the-glucose-methanol-choline-oxidoreductase-enzyme-superfamily-that-oxidizes-carbon-acids
#3
John M Robbins, Andreas S Bommarius, Giovanni Gadda
Formate oxidase (FOX) from Aspergillus oryzae is the only GMC member that oxidizes a carbon acid rather than alcohols; thus, its catalytic mechanism may be different from that of other GMC members. We have used pH, solvent viscosity, and deuterium kinetic isotope effects, to investigate the catalytic mechanism of FOX. The enzyme followed a Bi-Bi sequential steady-state kinetic mechanism. The kcat value was pH-independent between pH 2.8 and 6.8, suggesting lack of ionizable groups in kinetic step(s) that limit the overall turnover of the enzyme...
February 16, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29457909/droplet-translation-actuated-by-photoelectrowetting
#4
Cesar Palma, Robert David Deegan
In traditional electrowetting-on-dielectric devices droplet are moved about a substrate using electric fields produced by an array of discrete electrodes. Here we show that a drop can be driven across a substrate with a localized light beam by exploiting the photoelectrowetting effect, a light-activated variant of electrowetting-on-dielectric. Droplet transport actuated by photoelectrowetting eliminates the need for electrode arrays and the complexities entailed in their fabrication and control, and offers a new approach for designing lab-on-a-chip applications...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457726/a-robust-oil-in-oil-emulsion-for-the-nonaqueous-encapsulation-of-hydrophilic-payloads
#5
Xiaocun Lu, Joshua S Katz, Adam Schmitt, Jeffrey S Moore
Compartmentalized structures widely exist in cellular systems (organelles) and perform essential functions in smart composite materials (microcapsules, vasculatures, and micelles) to provide localized functionality and enhance materials compatibility. An entirely water-free compartmentalization system is of significant value to the materials community as nonaqueous conditions are critical to packaging microcapsules with water-free hydrophilic payloads while avoiding energy-intensive drying steps. Few nonaqueous encapsulation techniques are known, especially when considering just the scalable processes that operate in batch mode...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29457446/roll-to-roll-printing-of-meter-scale-composite-transparent-electrodes-with-optimized-mechanical-and-optical-properties-for-photoelectronics
#6
Xiangchuan Meng, Xiaotian Hu, Xia Yang, Jingping Yin, Qingxia Wang, Liqiang Huang, Zoukangning Yu, Ting Hu, Licheng Tan, Weihua Zhou, Yiwang Chen
Flexible transparent electrodes (FTEs) are an indispensable component for flexible optoelectronic devices. In this work, the meter-scale composite transparent electrode (CTEs) composing of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and Ag-grid/PET with optimized mechanical and optical properties is demonstrated by slot-die roll-to-roll technique with solution printing method under a low cost (2.8 $ for per square meter), via control of the viscosity and surface energy of PEDOT:PSS ink as well as the printing parameters...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29457132/scattered-wave-imaging-of-the-oceanic-plate-in-cascadia
#7
Catherine A Rychert, Nicholas Harmon, Saikiran Tharimena
Fifty years after plate tectonic theory was developed, the defining mechanism of the plate is still widely debated. The relatively short, simple history of young ocean lithosphere makes it an ideal place to determine the property that defines a plate, yet the remoteness and harshness of the seafloor have made precise imaging challenging. We use S -to- P receiver functions to image discontinuities beneath newly formed lithosphere at the Juan de Fuca and Gorda Ridges. We image a strong negative discontinuity at the base of the plate increasing from 20 to 45 km depth beneath the 0- to 10-million-year-old seafloor and a positive discontinuity at the onset of melting at 90 to 130 km depth...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29456008/ion-assisted-fabrication-of-neutral-protein-crosslinked-sodium-alginate-nanogels
#8
Xing Wei, Hejian Xiong, Dongfang Zhou, Xiabin Jing, Yubin Huang
Protein crosslinked nanogels which combine the merits of nanogels and the specific biological activity from protein have emerged as fascinating protein delivery systems. However, the fragility and low density of reactive group in proteins, especially low electric density of neutral proteins seriously limited the fabrication of protein crosslinked nanogels without affecting their bioactivities. Here, we demonstrated a facile ion-assisted method to fabricate neutral protein crosslinked nanogels. Oxidized sodium alginate (OSA) with aldehyde groups and low viscosity was successfully synthesized, which could reversibly form nanogels via addition and removal of divalent cation...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455992/nanosilver-leverage-on-reactive-dyeing-of-cellulose-fibers-color-shading-color-fastness-and-biocidal-potentials
#9
Hanan B Ahmed, Hossam E Emam, Hamada M Mashaly, Mohamed Rehan
The current approach focuses on studying the leverage of nanosilver (AgNPs) incorporation on the dyeing process of viscose fibers by blue reactive dye. Nanosilver was straightway incorporated into viscose fibers using sodium citrate as nanogenerator. Owing to AgNPs incorporation, color of fibers was turned to greenish-blue and darker greenish color was observed with low Ag content (<1 g/kg). Regardless to the processes sequencing, color strength of fibers was magnified by increasing in Ag content. The constancy of fibers color was not affected by AgNPs inclusion, whatever the processes sequencing and Ag content...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455991/water-soluble-chitosan-derivatives-and-ph-responsive-hydrogels-by-selective-c-6-oxidation-mediated-by-tempo-laccase-redox-system
#10
Suse Botelho da Silva, Malgorzata Krolicka, Lambertus A M van den Broek, August E Frissen, Carmen Gabriela Boeriu
Chitosan is a polysaccharide with recognized antioxidant, antimicrobial and wound healing activities. However, this polymer is soluble only in dilute acidic solutions, which restricts much of its applications. A usual strategy for improving the functionality of polysaccharides is the selective oxidation mediated by 2,2,6,6-tetra-methyl-1-piperidinidyloxy (TEMPO) using laccase as a co-oxidant. In this work, the TEMPO-laccase redox system was used for the first time to selectively oxidize chitosan in order to produce tailored derivatives...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455133/viscous-effects-on-the-interaction-of-granular-particles-with-floating-oils-in-water
#11
Berrin Tansel, Daria Boglaienko
Light hydrophobic liquids (LHLs) can be submerged in water with granular particles by forming particle encapsulated liquid sacks. Formation and submergence of granular encapsulated LHL sacks can be an effective method for capturing and controlling the fate of floating oils. However, formation characteristics of the LHL sacks and effect of LHL viscosity on their behavior are not well understood. In this study, we examined the encapsulation characteristics of LHL sacks depending on liquid viscosity. Silicone oils with viscosities ranging from 10cSt to 1000cSt were used as the LHLs...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29455043/ultra-early-injection-of-low-viscosity-cement-in-vertebroplasty-procedure-for-treating-osteoporotic-vertebral-compression-fractures-a-retrospective-cohort-study
#12
Zhao-Fei Zhang, Dong-Hua Liu, Pei-Yu Wu, Chun-Liang Xie, Feng-Wei Qin, He Huang
OBJECTIVE: To evaluate the clinical effect of ultra-early injection (before the phase of "tooth-paste-like") of low-viscosity cement in percutaneous vertebroplasty (PVP) for treating osteoporotic vertebral compression fractures (OVCFs). METHODS: Two hundred sixty-one patients who had PVP procedures with low-viscosity cement (ultra-early injection: 145, normal injection: 135) were included from July 2010 to July 2016 in our hospital. Visual Analog Scale (VAS), Oswestry Disability Index (ODI), Cobb angle, cement leakage, and adjacent vertebral fractures were evaluated...
February 15, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29454955/physicochemical-properties-of-starch-adhesives-enhanced-by-esterification-modification-with-dodecenyl-succinic-anhydride
#13
Yadong Sun, Jiyou Gu, Haiyan Tan, Yanhua Zhang, Pengfei Huo
Starch-based adhesives were prepared by esterification modification with dodecenyl succinic anhydride (DDSA) and polyaryl polymethylene isocyanate (PAPI) as a crosslinking agent. DDSA modified starch (DMS) adhesives could significantly enhance the viscosity and adhesion strength of starch adhesives, making it beneficial to be applied in the field of plywood industry. This paper investigated the physicochemical properties of starch modified by dodecenyl succinic anhydride. Solid content, viscosity, adhesion, structural change and morphological features were characterized in detail...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454951/the-role-of-sucrose-concentration-in-self-assembly-kinetics-of-high-methoxyl-pectin
#14
Daniela Giacomazza, Donatella Bulone, Pier Luigi San Biagio, Rosamaria Marino, Romano Lapasin
Several natural and synthetic polysaccharides are able to form, under appropriate conditions, supramolecular structures, typically physical hydrogels, and, together with their biocompatibility, this explains their wide use in food, pharmaceutical and biomedical sectors. In the case of high methoxyl pectins (HMP) the gel formation is promoted by the presence of cosolutes (sugars or polyols) and low pH. The present investigation mainly regards the structuring kinetics of aqueous HMP solutions at acid pH (3.1) with the same pectin concentration (0...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454624/the-synergetic-effects-of-non-polar-and-polar-protic-solvents-on-the-properties-of-felodipine-and-soluplus-in-solutions-casting-films-and-spray-dried-solid-dispersions
#15
Yuqi Chen, Wencong Huang, Jiali Chen, Hanning Wang, Shujuan Zhang, Subin Xiong
The aim was to explore the effects of non-polar and polar protic solvents composed of dichloromethane (DCM) and ethanol (EtOH) on the properties of felodipine (FLDP) and Soluplus in solutions, casting films and spray dried drug-rich or polymer-rich solid dispersions (SDs). Measurement of intrinsic viscosity and solubility indicated that FLDP and Soluplus were miscible. EtOH-DCM ranging from 20:80 to 50:50 induced the strongest molecular interactions for FLDP-Soluplus-solvents systems. Accordingly, the casting films and spray dried powders of FLDP and Soluplus were prepared using pure EtOH or DCM and their mixtures as solvents...
February 15, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29454188/modified-two-step-emulsion-solvent-evaporation-technique-for-fabricating-biodegradable-rod-shaped-particles-in-the-submicron-size-range
#16
Hanieh Safari, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
HYPOTHESIS: Though the emulsion solvent evaporation (ESE) technique has been previously modified to produce rod-shaped particles, it cannot generate small-sized rods for drug delivery applications due to the inherent coupling and contradicting requirements for the formation versus stretching of droplets. The separation of the droplet formation from the stretching step should enable the creation of submicron droplets that are then stretched in the second stage by manipulation of the system viscosity along with the surface-active molecule and oil-phase solvent...
February 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29452188/phosphate-fertilization-changes-the-characteristics-of-ma%C3%A3-%C3%A3-banana-starch
#17
Camila de Barros Mesquita, Émerson Loli Garcia, Ana Carolina Batista Bolfarini, Sarita Leonel, Célia Maria L Franco, Magali Leonel
The unripe banana has been studied as a potential source of starch for use in various applications. Considering the importance of phosphorus in the biosynthesis of the starch and also the interference of this mineral in starch properties, in this study it was evaluated the effect of rates of phosphate fertilizer applied in the cultivation of 'Maçã' banana on the characteristics of the starch. Starches extracted from fruits from different treatments were analyzed for morphological characteristics, X-ray diffraction pattern, relative crystallinity, granule size, amylose, resistant starch and phosphorus levels, as well as, for pasting and thermal properties...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29450473/elevated-blood-viscosity-and-micro-recirculation-linked-to-coronary-stent-malapposition
#18
Eric Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yap, Po Kuo, Qisen Wang, Jiawei Ma, Shuang Zhu, Stephen Moore, Andrew Ooi
One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis. By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance...
February 14, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29450422/remarkable-structural-effects-on-the-complexation-of-actinides-with-h-phosphonates-a-combined-experimental-and-quantum-chemical-study
#19
Aditi Chandrasekar, Brahmmananda Rao C V S, Mahesh Sundararajan, Tapan K Ghanty, N Sivaraman
The structural effects of the carbon chain on the extraction of actinides by organo-phosphorus extractants have been examined experimentally and by computation. Branched butyl H-phosphonates and their linear chain isomer, n-butyl H-phosphonate (DBHP), were synthesised and characterised using IR, NMR and GC-MS techniques. Their physical properties viz. viscosity, density and aqueous solubility have been examined. DBHP, Di-iso-butyl H phosphonate (DiBHP) and Di-sec-butyl H phosphonate (DsBHP) were employed for the extraction of uranium and americium ions from nitric acid...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29448794/short-time-dynamics-of-lysozyme-solutions-with-competing-short-range-attraction-and-long-range-repulsion-experiment-and-theory
#20
Jonas Riest, Gerhard Nägele, Yun Liu, Norman J Wagner, P Douglas Godfrin
Recently, atypical static features of microstructural ordering in low-salinity lysozyme protein solutions have been extensively explored experimentally and explained theoretically based on a short-range attractive plus long-range repulsive (SALR) interaction potential. However, the protein dynamics and the relationship to the atypical SALR structure remain to be demonstrated. Here, the applicability of semi-analytic theoretical methods predicting diffusion properties and viscosity in isotropic particle suspensions to low-salinity lysozyme protein solutions is tested...
February 14, 2018: Journal of Chemical Physics
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