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https://www.readbyqxmd.com/read/28931726/impaired-insulin-igf-1-is-responsible-for-diabetic-gastroparesis-by-damaging-myenteric-cholinergic-neurons-and-interstitial-cells-of-cajal
#1
Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou
Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment but not glycemic control potently accelerated gastric emptying in type 1 DM patients, the role of insulin/InsR and IGF-1/IGF-1R signaling in diabetic gastroparesis remains incompletely elucidated. In this study, type 1 DM mice were established and treated with insulin or Voglibose for 8 weeks. The gastric emptying was delayed from DM week 4 when the gastric InsR and IGF-1R were declined...
September 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28931532/genetic-variation-of-habitual-coffee-consumption-and-glycemic-changes-in-response-to-weight-loss-diet-intervention-the-preventing-overweight-using-novel-dietary-strategies-pounds-lost-trial
#2
Liyuan Han, Wenjie Ma, Dianjianyi Sun, Yoriko Heianza, Tiange Wang, Yan Zheng, Tao Huang, Donghui Duan, J George A Bray, Catherine M Champagne, Frank M Sacks, Lu Qi
Background: Coffee consumption has been associated with glucose metabolism and risk of type 2 diabetes.Objective: We examined whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention.Design: A genetic risk score (GRS) was calculated based on 8 habitual coffee consumption-associated single nucleotide polymorphisms. We used general linear models to test changes in glycemic traits in groups randomly assigned to high- and low-fat diets according to tertiles of the GRS...
September 20, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28928674/the-gly-16-allele-of-the-g16r-single-nucleotide-polymorphism-in-the-%C3%AE-2-adrenergic-receptor-gene-augments-the-glycemic-response-to-adrenaline-in-humans
#3
Kim Z Rokamp, Jonatan M Staalsø, Morten Zaar, Peter Rasmussen, Lonnie G Petersen, Rikke V Nielsen, Niels H Secher, Niels V Olsen, Henning B Nielsen
Cerebral non-oxidative carbohydrate consumption may be driven by a β2-adrenergic mechanism. This study tested whether the 46G > A (G16R) single nucleotide polymorphism of the β2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenaline. Forty healthy Caucasian men were included from a group of genotyped individuals. Cardio- and cerebrovascular variables at baseline and during a 60-min adrenaline infusion (0.06 μg kg(-1) min(-1)) were measured by Model flow, near-infrared spectroscopy and transcranial Doppler sonography...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28927968/multiple-educational-programs-improves-glycemic-control-quality-of-life-with-diminishing-the-impact-of-diabetes-in-poorly-controlled-type-1-diabetics
#4
Chintan Vyas, Lopa Dalal, Praful Talaviya, Banshi Saboo
AIMS: The aim of present study was to assess the outcomes of multiple educational programs on glycemic control, quality of life and impact of diabetes in poorly controlled Type 1 Diabetic patients. PARTICIPANTS AND METHODS: A 12 months diabetes education programs were conducted every week for first one month then followed by every 3 months with follow up on improvement of HbA1c and QOL in T1D patients (n=54). Clinical characteristics were recorded at baseline visit...
April 12, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28927270/proteomic-analysis-of-peripheral-blood-mononuclear-cells-pbmc-after-a-high-fat-high-carbohydrate-meal-with-orange-juice
#5
Daniela F Seixas Chaves, Paulo C Carvalho, Elisa Brasili, Marcelo Macedo Rogero, Neuza Mariko Aymoto Hassimotto, Jolene K Diedrich, James J Moresco, John R Yates, Franco Maria Lajolo
Oxidative stress and inflammation play a role in the physiopathology of insulin resistance, diabetes and cardiovascular disease. A single high-fat, high-carbohydrate (HFHC) meal induces an increase in inflammatory and oxidative stress markers in peripheral blood mononuclear cells (PBMC). Previous studies have shown that orange juice is able to prevent this response by inhibiting toll like receptors (TLR) expression and endotoxemia. Our goal was to study the proteome response in PBMC after the consumption of a HFHC meal consumed with water, orange juice or an isocaloric beverage (water with glucose)...
September 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28926965/glycemic-responses-glycemic-index-and-glycemic-load-values-of-some-street-foods-prepared-from-plantain-musa-spp-aab-genome-in-c%C3%A3-te-d-ivoire
#6
Camille Adam Kouamé, Nestor Kouakou Kouassi, Denis Yao N'dri, Kingsley Kwadwo Asare Pereko, Maria Cristina Casiraghi, Abodo Jacko Rhedoor, Georges N'guessan Amani
The glycemic index (GI) and glycemic load (GL) of four culinary preferences including five local street dishes prepared from three varieties of plantain at different maturity stages was determined. The GI was obtained following ISO/FDI 26642:2010 protocol, and the GL was calculated from test foods' GI, considering the amount of available carbohydrate in the traditional portion size. GI values were 44 for Klaclo (with Ameletiha variety at all black stage), 39 for Aloco (with Agnrin variety at full yellow stage), 39 for Aloco (with Agnrin variety at full yellow with black spots stage); 45 for Chips (with Ameletiha variety at green stage) and 89 for Banane braisée (with Afoto variety at light green stage)...
September 16, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28926170/efficacy-and-safety-of-saxagliptin-in-combination-with-metformin-as-initial-therapy-in-chinese-patients-with-type-2-diabetes-results-from-the-start-study-a-multicenter-randomized-double-blind-active-controlled-phase-3-trial
#7
Jingtao Dou, Jianhua Ma, Jun Liu, Changjiang Wang, Eva Johnsson, Hui Yao, June Zhao, Changyu Pan
OBJECTIVE: To assess the efficacy and safety of saxagliptin plus metformin over 24 weeks in pharmacotherapy-naïve Chinese patients with type 2 diabetes mellitus and inadequate glycemic control (HbA1c 8.0-12.0%). RESEARCH DESIGN AND METHODS: In this multicenter, double-blind, active-controlled study (The START study: NCT02273050), patients were randomized (1:1:1) to saxagliptin 5 mg plus metformin, saxagliptin 5 mg plus placebo, or metformin plus placebo. Saxagliptin was taken once daily; metformin was taken once/twice daily and was titrated from 500 mg to a maximum of 2000 mg/day over 8 weeks...
September 19, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28922065/a-study-examining-the-effect-of-a-short-bout-of-postprandial-walking-on-the-glycemic-effect-of-a-meal-type-1-diabetes
#8
Samantha L Hinojosa, Cynthia J Heiss
OBJECTIVE: The purpose of this pilot study was to determine whether 15 minutes of postprandial walking has an effect on the glycemic response to a breakfast beverage in individuals with type 1 diabetes (T1DM). METHODS: Seven participants, aged 22.3 ± 4.3 years, with T1DM using intensive insulin therapy completed 2 days of data collection. On day 1, participants measured baseline fasting blood glucose (BG) with a glucometer, consumed an 8-ounce Boost® beverage (41 grams carbohydrate), administered a bolus of insulin according to the carbohydrate load and fasting BG, and sat quietly, repeating BG measurements 15, 30, 60, 90, and 120 minutes after consumption...
September 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28903959/effect-of-prior-meal-macronutrient-composition-on-postprandial-glycemic-responses-and-glycemic-index-and-glycemic-load-value-determinations
#9
Huicui Meng, Nirupa R Matthan, Lynne M Ausman, Alice H Lichtenstein
Background: The potential impact of prior meal composition on the postprandial glycemic response and glycemic index (GI) and glycemic load (GL) value determinations remains unclear.Objective: We determined the effect of meals that varied in macronutrient composition on the glycemic response and determination of GI and GL values of a subsequent standard test food.Design: Twenty healthy participants underwent 6 test sessions within 12 wk. The subjects received each of 3 isocaloric breakfast meals (i.e., high carbohydrate, high fat, or high protein) on separate days in a random order, which was followed by a standard set of challenges (i...
September 13, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#10
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28898874/associations-between-liver-enzyme-levels-and-parameters-of-the-metabolic-syndrome-in-obese-children
#11
Christiane S Hampe, Michele L Shaffer, Christian L Roth
BACKGROUND: Obesity is strongly associated with insulin resistance, hypertension, dyslipidemia, and therefore risk for metabolic syndrome (MetS), which is an increasing problem in youth. The potential role of elevated liver enzyme levels in this context needs to be further investigated. METHODS: This paper provides a post hoc analysis of a cross-sectional study of 77 obese nondiabetic children (51% female; median age 11.7 years; BMI >97th percentile) enrolled at the University of Bonn, Bonn, Germany...
September 12, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28886437/apple-and-blackcurrant-polyphenol-rich-drinks-decrease-postprandial-glucose-insulin-and-incretin-response-to-a-high-carbohydrate-meal-in-healthy-men-and-women
#12
Monica L Castro-Acosta, Stephanie G Stone, Jonathan E Mok, Rhia K Mhajan, Chi-Ieng Fu, Georgia N Lenihan-Geels, Christopher P Corpe, Wendy L Hall
Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant polyphenol-rich drinks would reduce postprandial blood glucose concentrations. Secondary outcomes included insulin and glucose-dependent insulinotropic polypeptide (GIP) secretion. Twenty men (mean age 26 y, SD 8) and 5 postmenopausal women (mean age 57 y, SD 3) consumed a placebo drink (CON) and 2 polyphenol-rich drinks containing fruit extracts: either 1200 mg apple polyphenols (AE), or 600 mg apple polyphenols+600 mg blackcurrant anthocyanins (AE+BE), in random order with a starch and sucrose meal...
July 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28880049/sleep-and-glycemic-control-in-adolescents-with-type-1-diabetes
#13
Julia von Schnurbein, Claudia Boettcher, Stephanie Brandt, Beate Karges, Desiree Dunstheimer, Angela Galler, Christian Denzer, Friederike Denzer, Heike Vollbach, Martin Wabitsch, Till Roenneberg, Celine Vetter
BACKGROUND: Increasing evidence link sleep curtailment and circadian misalignment with adverse metabolic outcome. Adolescents might be most affected, given their late sleep timing and early school and work start times. OBJECTIVE: Our aim was to examine the impact of poor sleeping habits on glycemic control in adolescents with type 1 diabetes. SUBJECTS AND METHODS: This was a non-interventional multicenter study across Germany recruiting pubertally mature adolescents with type 1 diabetes...
June 14, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28878943/obstructive-sleep-apnea-in-adults-with-type-1-and-type-2-diabetes-perspectives-from-a-quality-improvement-initiative-in-a-university-based-diabetes-center
#14
Simona Ioja, Eileen R Chasens, Jason Ng, Patrick J Strollo, Mary T Korytkowski
OBJECTIVE: Obstructive sleep apnea (OSA) and diabetes are frequent comorbid conditions. Screening for OSA in patients with diabetes is recommended but the frequency with which this is done in clinical practice is unknown. The objectives of this quality improvement initiative were to identify clinician and patient perceptions regarding OSA and to identify the prevalence of patients at high risk for OSA (HROSA). METHODS: A quality improvement initiative was conducted to query clinicians and patients attending a specialty diabetes clinic regarding attitudes and beliefs related to OSA...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28875237/uncoupling-protein-2-inhibition-exacerbates-glucose-fluctuation-mediated-neuronal-effects
#15
Susana Cardoso, Raquel M Seiça, Paula I Moreira
Though glucose fluctuations have been considered as an adverse factor for the development of several diabetes-related complications, their impact in the central nervous system is still not fully elucidated. This study was conducted to evaluate the responses of neuronal cells to different glycemic exposures alongside to elucidate the role of uncoupling protein 2 (UCP2) in regulating such responses. To achieve our goals, primary cortical neurons were submitted to constant high (HG)/low (LG) or glucose level variations (GVs), and the pharmacological inhibition of UCP2 activity was performed using genipin...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28870473/short-term-effects-of-a-low-glycemic-index-carob-containing-snack-on-energy-intake-satiety-and-glycemic-response-in-normal-weight-healthy-adults-results-from-two-randomized-trials
#16
Emilia Papakonstantinou, Nickolaos Orfanakos, Paul Farajian, Anastasia E Kapetanakou, Ifigenia P Makariti, Nikolaos Grivokostopoulos, Marie-Ann Ha, Panagiotis N Skandamis
OBJECTIVES: The potential positive health effects of carob-containing snacks are largely unknown. Therefore, the aims of these studies were to determine the glycemic index (GI) of a carob snack compared with chocolate cookie containing equal amounts of available carbohydrates and to compare the effects of a carob versus chocolate cookie preload consumed as snack before a meal on (a) short-term satiety response measured by subsequent ad libitum meal intake, (b) subjective satiety as assessed by visual analog scales and (c) postprandial glycemic response...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28868829/factors-associated-with-improved-glycemic-control-by-direct-acting-antiviral-agent-treatment-in-egyptian-type-2-diabetes-mellitus-patients-with-chronic-hepatitis-c-genotype-4
#17
Alaaeldin Abdelsalam Dawood, Mohamed Zakarya Nooh, Ayman Abdelhaleem Elgamal
BACKGROUND: The association of chronic hepatitis C virus (HCV) infection with type 2 diabetes mellitus (T2DM) was first reported in 1994. Little is known about the effect of direct-acting antiviral agents (DAAs) on glycemic control in T2DM patients. The aim of the present study was to evaluate the factors associated with improved glycemic control (IGC) by DAA treatment in Egyptian T2DM patients with chronic HCV genotype 4 infection. METHODS: This study included 460 T2DM patients with chronic HCV genotype 4 infection...
August 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28864058/barriers-to-insulin-initiation-in-elderly-patients-with-type-2-diabetes-mellitus-in-brazil
#18
Freddy G Eliaschewitz, Mauricio A de Paula, Hermelinda C Pedrosa, Antônio Carlos Pires, João Eduardo N Salles, Marcos Antônio Tambascia, Luiz Alberto A Turatti
AIMS: We aimed to explore insulin initiation barriers in the Brazilian Type 2 Diabetes Mellitus (T2DM) elderly population, according to the physician's perspective, and suggest strategies to overcome them. METHODS: A 45-questions survey addressing issues as clinical characteristics, barriers to insulinization, and treatment strategies in elderly patients with T2DM, was sent to six endocrinologists from different Brazilian locations. Thereafter, all the respondents participated in a panel discussion to validate their responses and collect additional relevant data...
August 25, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28860128/opioid-receptor-activation-impairs-hypoglycemic-counterregulation-in-humans
#19
Michelle Carey, Rebekah Gospin, Akankasha Goyal, Nora Tomuta, Oana Sandu, Armand Mbanya, Eric Lontchi-Yimagou, Raphael Hulkower, Harry Shamoon, Ilan Gabriely, Meredith Hawkins
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus, iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as Hypoglycemia-Associated Autonomic Failure (HAAF). To determine whether and how opioid receptor activation induces HAAF in humans, twelve healthy, non-diabetic subjects (7M, age 32.3 ± 2.2 yr, BMI 25.1 ± 1.0 kg/m2) participated in two study protocols in random order over two consecutive days...
August 31, 2017: Diabetes
https://www.readbyqxmd.com/read/28855269/roles-of-increased-glycemic-variability-glp-1-and-glucagon-in-hypoglycaemia-after-roux-en-y-gastric-bypass
#20
George Tharakan, Preeshila Behary, Nicolai Jacob Wewer Albrechtsen, Harvinder Chahal, Julia Kenkre, Alexander D Miras, Ahmed R Ahmed, Jens Juul Holst, Steve R Bloom, Tricia Mei Mei Tan
Objective Roux-en-Y Gastric Bypass (RYGB) surgery is currently the most effective treatment for diabetes and obesity. An increasingly recognized complication of RYGB surgery is postprandial hypoglycemia (PPH). The pathophysiology of PPH remains unclear with multiple mechanisms suggested including nesidioblastosis, altered insulin clearance and increased glucagon-like-1 peptide (GLP-1) secretion. Whilst many PPH patients respond to dietary modification, some have severely disabling symptoms. Multiple treatments have been trialled ranging from acarbose, to both GLP-1 agonists and antagonists, even to reversal of RYGB...
August 30, 2017: European Journal of Endocrinology
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