keyword
https://read.qxmd.com/read/38546831/physiological-appetite-regulation-and-bariatric-surgery
#1
REVIEW
Indra Ramasamy
Obesity remains a common metabolic disorder and a threat to health as it is associated with numerous complications. Lifestyle modifications and caloric restriction can achieve limited weight loss. Bariatric surgery is an effective way of achieving substantial weight loss as well as glycemic control secondary to weight-related type 2 diabetes mellitus. It has been suggested that an anorexigenic gut hormone response following bariatric surgery contributes to weight loss. Understanding the changes in gut hormones and their contribution to weight loss physiology can lead to new therapeutic treatments for weight loss...
February 27, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38546545/template-free-self-assembly-of-hollow-microtubular-covalent-organic-frameworks-for-oral-delivery-of-insulin
#2
JOURNAL ARTICLE
Lihui Dai, Fang Wu, Yi Xiao, Qian Liu, Meng Meng, Rimo Xi, Yongmei Yin
Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to our knowledge, the first template-free self-assembled COF-18 Å hollow microtubule (MT-COF-18 Å) structure and its use for insulin delivery that exhibits high loading capacity, gastroresistance, and glucose-responsive properties. The hollow MT-COF-18 Å was achieved by a template-free method benefiting from the mixed solvents of mesitylene and dioxane...
March 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38542455/-anaerobutyricum-soehngenii-reduces-hepatic-lipogenic-pathways-and-increases-intestinal-gluconeogenic-gene-expression-in-metabolic-dysfunction-associated-steatotic-liver-disease-masld-mice
#3
JOURNAL ARTICLE
Anne Linde Mak, Quinten J J Augustijn, Clément J F Heymann, Stefan Havik, Xanthe Verdoes, Melany Rios-Morales, Laura A Bosmans, Joanne Verheij, Abraham S Meijnikman, Patrick A de Jonge, Hilde Herrema, Willem M de Vos, Max Nieuwdorp, Aldo Grefhorst, Adriaan G Holleboom
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a growing health problem for which no therapy exists to date. The modulation of the gut microbiome may have treatment potential for MASLD. Here, we investigated Anaerobutyricum soehngenii , a butyrate-producing anaerobic bacterium with beneficial effects in metabolic syndrome, in a diet-induced MASLD mouse model. Male C57BL/6J mice received a Western-type high-fat diet and water with 15% fructose (WDF) to induce MASLD and were gavaged with A...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541649/sucralose-from-sweet-success-to-metabolic-controversies-unraveling-the-global-health-implications-of-a-pervasive-non-caloric-artificial-sweetener
#4
REVIEW
José Alfredo Aguayo-Guerrero, Lucía Angélica Méndez-García, Helena Solleiro-Villavicencio, Rebeca Viurcos-Sanabria, Galileo Escobedo
Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion. We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response...
February 29, 2024: Life
https://read.qxmd.com/read/38540910/effect-of-sugar-free-jelly-on-glycemic-metabolism-and-its-potential-health-benefits-in-non-diabetic-adults
#5
JOURNAL ARTICLE
Heejin Han, Yuri Kim, Minchul Gim, Hoyeon Shin, Hyunsook Jang, Won Joo Yoon, Gyeong-Hweon Lee, Yoo Kyoung Park
Excessive sugar consumption provides energy but has little nutritional value, contributing to the prevalence of obesity. Hence, "sugar-free" products using artificial or natural sweeteners, including sugar alcohols, have become popular. Accordingly, safety concerns and curiosity have arisen. Therefore, this study used a double-blind, crossover design to compare the effects of commercial sugar-free and sugar jellies (control) on the glycemic response in 16 adults without diabetes. Blood samples were collected to measure blood glucose, insulin, glucagon, ghrelin, C-peptide, glycated hemoglobin, and glycated albumin levels, and an oral glucose tolerance test was performed...
March 18, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38535216/-fggmtb-plays-an-important-role-in-growth-reproduction-virulence-and-deoxynivalenol-biosynthesis-of-fusarium-graminearum
#6
JOURNAL ARTICLE
Chenming Zhao, Xiaoyue Yang, Wenqiang Jiang, Guifen Zhang, Dongfang Ma
GDP-mannose transporters (GMTs) have been implicated in the virulence of some important pathogenic fungi, and guanosine diphosphate (GDP) mannose transporters transport GDP-mannose from the cytosol to the Golgi lumen prior to mannosylation, where mannose attaches to the modified protein. GMTs could be potential targets for new antifungal drugs, as disruption of any step in GDP-mannose biosynthesis can affect fungal viability, growth, or virulence. To date, the GDP-mannose transporter has been extensively studied in yeast, but its biological function in fungi, particularly F...
March 11, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534382/tofogliflozin-delays-portal-hypertension-and-hepatic-fibrosis-by-inhibiting-sinusoidal-capillarization-in-cirrhotic-rats
#7
JOURNAL ARTICLE
Shohei Asada, Kosuke Kaji, Norihisa Nishimura, Aritoshi Koizumi, Takuya Matsuda, Misako Tanaka, Nobuyuki Yorioka, Shinya Sato, Koh Kitagawa, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
BACKGROUND: Liver cirrhosis leads to portal hypertension (PH) with capillarization of liver sinusoidal endothelial cells (LSECs), although drug treatment options for PH are currently limited. Sodium glucose transporter 2 inhibitors, which are antidiabetic agents, have been shown to improve endothelial dysfunction. We aimed to elucidate the effect of tofogliflozin on PH and liver fibrosis in a rat cirrhosis model. METHODS: Male-F344/NSlc rats repeatedly received carbon tetrachloride (CCl4 ) intraperitoneally to induce PH and liver cirrhosis alongside tofogliflozin (10 or 20 mg/kg)...
March 19, 2024: Cells
https://read.qxmd.com/read/38522692/enhanced-hypoglycemic-effects-of-konjac-glucomannan-combined-with-polygonatum-cyrtonema-hua-polysaccharide-in-complete-nutritional-liquid-diet-fed-type-2-diabetes-mice
#8
JOURNAL ARTICLE
Le Chang, H Douglas Goff, Chao Ding, Qiang Liu, Siqi Zhao, Tingting Tao, Rongxin Lu, Ying Gao, Haijing Wu, Liping Guo
In our aging society, dysphagia and malnutrition are growing concerns, necessitating intervention. Liquid nutrition support offers a practical solution for traditional dietary issues, but it raises a key issue: the potential for post-meal glucose spikes impacting efficacy. This study examined the effects of supplementation of Polygonatum cyrtonema Hua polysaccharide (PCP), konjac glucomannan (KGM) and their combination on acute phase postprandial glycemic response and long-term glucose metabolism in T2DM mice on a complete nutritional liquid diet...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38519028/role-of-teplizumab-a-humanized-anti-cd3-monoclonal-antibody-in-managing-newly-diagnosed-type-1-diabetes-an-updated-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
A B M Kamrul-Hasan, Sunetra Mondal, Lakshmi Nagendra, Ashmita Yadav, Fatema Tuz Zahura Aalpona, Deep Dutta
BACKGROUND: Teplizumab has emerged as a potential disease-modifying drug in type 1 diabetes (T1D). This meta-analysis sought to summarize the therapeutic effect of teplizumab in newly diagnosed patients with T1D. METHODS: Randomized controlled trials (RCTs) involving patients with T1D receiving teplizumab in the intervention arm and placebo (or no active intervention) in the control arm were searched throughout the electronic databases. The primary outcome was the change in area under the curve (AUC) of C-peptide levels from baseline...
March 20, 2024: Endocrine Practice
https://read.qxmd.com/read/38513314/second-order-scattering-sensor-based-on-the-zn-0-97-la-0-03-o-compound-for-selective-and-stable-detection-of-glycated-albumin
#10
JOURNAL ARTICLE
José Jonathan Soares Dos Santos, Ramon Raudel Peña Garcia, Adriano Santana Soares, Elias Gabriel de Amorim Silva, Jorge Luiz Neves, Thaís Meira Menezes
Here, we presented a second-order scattering sensor based on the Zn0.97 La0.03 O compound (LaZnO) for selective and stable detection of glycated albumin (GA, glycemic long-term biomarker). The LaZnO sample was obtained through the co-precipitation method and then characterized using microscopic and spectroscopic techniques. Furthermore, the selectivity, molecular interference, temporal stability, and pH effects of the LaZnO SOS signal in the absence and presence of GA were investigated. The results indicate the stability of the SOS signal over more than 60 days...
March 19, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38503103/association-of-phthalate-exposure-with-type-2-diabetes-and-the-mediating-effect-of-oxidative-stress-a-case-control-and-computational-toxicology-study
#11
JOURNAL ARTICLE
Yuxuan Tan, Ziang Guo, Huojie Yao, Han Liu, Yingyin Fu, Yangxu Luo, Rong He, Yiwan Liu, Pei Li, Lihong Nie, Lei Tan, Chunxia Jing
Phthalic acid esters (PAEs) are widely used as plasticizers and have been suggested to engender adverse effects on glucose metabolism. However, epidemiological data regarding the PAE mixture on type 2 diabetes (T2DM), as well as the mediating role of oxidative stress are scarce. This case-control study enrolled 206 T2DM cases and 206 matched controls in Guangdong Province, southern China. The concentrations of eleven phthalate metabolites (mPAEs) and the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine were determined...
March 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38497881/metabolic-control-level-and-glucose-variability-in-adolescents-with-type-1-diabetes-during-low-and-high-intensity-exercise
#12
JOURNAL ARTICLE
M Skalska, A Myśliwiec, A Michalak, J Chrzanowski, A Lejk, J Jastrzębska, Ł Radzimiński, G F Lopez-Sanchez, K Myśliwiec, Z Jastrzębski, K Weiss, B Knechtle
OBJECTIVE: The main purpose of this study was to characterize the determinants of metabolic changes in young type 1 diabetes (T1DM) and to determine glycemic variability during low and high-intensity exercise. PATIENTS AND METHODS: 20 young male T1DM patients were divided into two subgroups characterized by levels of glycated hemoglobin (HbA1c): HbA1c<7.3% (better HbA1c subgroup, n=10) and with levels HbA1c>7.3% (worse HbA1c subgroup, n=10). All participants performed a maximal oxygen uptake test and two efforts of various intensities (45 minutes of aerobic exercise and 30 minutes of mixed aerobic-anaerobic intensity exercise)...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38495396/a-case-of-maturity-onset-diabetes-of-the-young-with-complex-mutations
#13
Sheetal Bulchandani, Priya Kundra
Maturity-onset diabetes of the young (MODY) encompasses a group of rare monogenic forms of diabetes, with 14 subtypes described in the literature, each with a distinct underlying genetic mutation. We present a case with mutations in 2 different genes that are known to be responsible for MODY. A 33-year-old male individual presented to the endocrinology clinic for evaluation. He was diagnosed with type 2 diabetes mellitus at 13 years of age and was initially treated with insulin, which was subsequently switched to repaglinide and metformin...
March 2024: JCEM Case Rep
https://read.qxmd.com/read/38490800/assessing-the-readiness-to-transition-to-adult-care-perceived-medication-barriers-and-glycemic-control-among-teens-with-type-1-diabetes
#14
JOURNAL ARTICLE
Arwa Alhamed
AIM: This study assessed the readiness to transition (RT) from pediatric to adult care, perceived medication barriers (PMB), and glycemic control in teens with type one diabetes (T1D). BACKGROUND: During the transition from pediatric to adult care, teens with T1D are at risk of long-term complications related to impaired adherence. With the increasing prevalence of T1D in Saudi Arabia, research is required to identify the challenges facing teens with T1D during their transition...
February 2024: Applied Nursing Research: ANR
https://read.qxmd.com/read/38487986/effect-of-single-oral-coingestion-of-gaba-and-malic-acid-on-postprandial-glp-1-glucose-and-insulin-responses-in-healthy-volunteers-a-randomized-double-blind-placebo-controlled-crossover-study
#15
JOURNAL ARTICLE
Hiroki Noguchi, Takeshi Ikenaga, Shota Ueno, Chieko Kohashi, Yasuhiro Matsumura, Yusuke Kakumoto, Noriyuki Kohda, Hiroshi Hara, Tohru Hira
SCOPE: This study examines whether coingestion of γ-aminobutyric acid (GABA) and malic acid (MA) before meals enhances glucagon-like peptide-1 (GLP-1) secretion, and which affects subsequent insulin and glycemic responses in humans. METHODS AND RESULTS: Initially, a murine enteroendocrine STC-1 cell line is used to verify coadministration of GABA and MA synergistically induces GLP-1 secretion. Next, 22 healthy adults are given water (50 mL) containing 400 mg GABA and 400 mg MA (Test), or only 400 mg citric acid (CA) (Placebo) 20 min before meal tolerance test (MTT)...
March 15, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38480843/dichotomous-effect-of-dietary-fiber-in-pediatrics-a-narrative-review-of-the-health-benefits-and-tolerance-of-fiber
#16
REVIEW
Nandini Basuray, Edward C Deehan, Flávio T Vieira, Hayford M Avedzi, Reena L Duke, Eloisa Colín-Ramírez, Hein M Tun, Zhengxiao Zhang, Eytan Wine, Karen L Madsen, Catherine J Field, Andrea M Haqq
Dietary fibers are associated with favorable gastrointestinal, immune, and metabolic health outcomes when consumed at sufficient levels. Despite the well-described benefits of dietary fibers, children and adolescents continue to fall short of daily recommended levels. This gap in fiber intake (i.e., "fiber gap") might increase the risk of developing early-onset pediatric obesity and obesity-related comorbidities such as type 2 diabetes mellitus into adulthood. The structure-dependent physicochemical properties of dietary fiber are diverse...
March 13, 2024: European Journal of Clinical Nutrition
https://read.qxmd.com/read/38477483/the-effects-of-calorie-restriction-and-bariatric-surgery-on-circulating-proneurotensin-levels
#17
JOURNAL ARTICLE
Michael G Miskelly, Johan Berggren, Malin Svensson, Jukka Koffert, Henri Honka, Saila Kauhanen, Pirjo Nuutila, Jan Hedenbro, Andreas Lindqvist, Olle Melander, Nils Wierup
CONTEXT: Proneurotensin (pNT) is associated with obesity and T2D, but the effects of Roux-en-Y gastric bypass (RYGB) on postprandial pNT levels are not well studied. OBJECTIVE: Assess effects of RYGB versus very low-energy diet (VLED) on pNT levels in response to mixed-meal tests (MMT), and long-term effects of RYGB on fasting pNT.Study participants: Cohort 1: Nine normoglycemic (NG) and ten T2D patients underwent MMT before and after VLED, immediately post-RYGB and six weeks post-RYGB...
March 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38472769/comparative-study-of-the-nutritional-phytochemical-sensory-characteristics-and-glycemic-response-of-cookies-enriched-with-lupin-sprout-flour-and-lupin-green-sprout
#18
JOURNAL ARTICLE
Loredana Plustea, Sylvestre Dossa, Christine Dragomir, Ileana Cocan, Monica Negrea, Diana Obistioiu, Mariana-Atena Poiana, Daniela Voica, Adina Berbecea, Ersilia Alexa
This study aimed to compare the nutritional, phytochemical, and sensory characteristics of wheat flour (WF) cookies enriched with different proportions of lupin sprout flour (LSF) and those with different proportions of lupin green sprout (LGS). To achieve this, a control cookie (CC); three cookies with 10%, 20%, and 30% of LSF, respectively, CLSF1, CLSF2, and CLSF3; and three other cookies (CLGS1, CLGS2, and CLGS3) with 10%, 20%, and 30%, respectively, were produced. The proximate composition of each cookie was analyzed using AOAC methods...
February 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38471959/willingness-to-take-less-medication-for-type-2-diabetes-among-older-patients-the-diabetes-aging-study
#19
JOURNAL ARTICLE
Shanzay Haider, Melissa M Parker, Elbert S Huang, Richard W Grant, Howard H Moffet, Neda Laiteerapong, Rajesh K Jain, Jennifer Y Liu, Kasia J Lipska, Andrew J Karter
BACKGROUND: To examine the willingness of older patients to take less diabetes medication (de-intensify) and to identify characteristics associated with willingness to de-intensify treatment. METHODS: Survey conducted in 2019 in an age-stratified, random sample of older (65-100 years) adults with diabetes on glucose-lowering medications in the Kaiser Permanente Northern California Diabetes Registry. We classified survey responses to the question: "I would be willing to take less medication for my diabetes" as willing, neutral, or unwilling to de-intensify...
March 12, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38462850/development-and-characterization-of-physical-stability-glycemic-index-flow-behaviors-and-antioxidant-activity-of-finger-millet-based-beverage
#20
JOURNAL ARTICLE
Shivangi Mishra, Rakhi Singh, Ashutosh Upadhyay, Barjinder Pal Kaur, Shruti Shukla
Millets are gaining attention as a superfood due to their higher nutritional value and cost-effectiveness. In this regard, extraction condition for the development of finger millet-based beverage was optimized using a central composite design. Soaking time (X1 ) and temperature (X2 ) in the range of 5-10 h and 40-60°C, respectively, were the independent variables taken for three responses, namely, yield, total solids, and sedimentation index. The optimized conditions are best fitted in quadratic model (R2 0...
March 10, 2024: Journal of Food Science
keyword
keyword
62331
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.