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https://www.readbyqxmd.com/read/28323512/evaluating-the-costs-of-glycemic-response-with-canagliflozin-versus-dapagliflozin-and-empagliflozin-as-add-on-to-metformin-in-patients-with-type-2-diabetes-mellitus-in-the-united-arab-emirates
#1
Agata Schubert, Anders T Buchholt, Antoine C El Khoury, Ahmed Kamal, Vanessa Taieb
OBJECTIVE: This study evaluates the cost of achieving glycemic control with 3 sodium glucose co-transporter 2 (SGLT2) inhibitors, canagliflozin, dapagliflozin, and empagliflozin, in patients with type 2 diabetes mellitus (T2DM) from the payer perspective in the United Arab Emirates (UAE). METHODS: A systematic literature review identified randomized controlled trials of antihyperglycemic agents as add-on to metformin in patients with T2DM of 26 ± 4 weeks in duration, published by 10 September 2014...
March 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28321766/partnering-with-insurers-in-caring-for-the-most-vulnerable-youth-with-diabetes-nich-as-an-integrator
#2
REVIEW
Samantha A Barry, Lena Teplitsky, David V Wagner, Amit Shah, Brian T Rogers, Michael A Harris
PURPOSE OF REVIEW: In this review, we outline barriers to appropriately caring for high-risk youth with diabetes and discuss efforts in partnering with insurers through Alternative Payment Models to achieve the Triple Aim (improved health, improved care, and reduced costs) for this population. RECENT FINDINGS: Current approaches in caring for youth with diabetes who evidence a high degree of social complexity are woefully ineffective. These youth are vulnerable to repeat diabetic ketoacidosis episodes, poor glycemic control, and excessive utilization of healthcare resources...
April 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28321057/the-glucose-lowering-efficacy-of-sitagliptin-in-obese-japanese-patients-with-type-2-diabetes
#3
Ryo Kodera, Kenichi Shikata, Akihiko Nakamura, Satoru Okazaki, Ryo Nagase, Tatsuaki Nakatou, Shigeru Haisa, Kazuyuki Hida, Katsuhiro Miyashita, Hirofumi Makino
Objective Dipeptidyl peptidase-4 (DPP-4) inhibitors are the most frequently prescribed oral hypoglycemic agents in Japan. Although a relationship between the efficacy of DPP-4 inhibitors and the body mass index (BMI) has been reported, this relationship is controversial. We investigated whether the BMI value affects the glucose-lowering efficacy of sitagliptin in obese Japanese patients with type 2 diabetes. Methods One hundred sixty-two outpatients with inadequate glycemic control were divided into four groups based on their baseline BMI values...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28303040/assessment-of-maillard-reaction-evolution-prebiotic-carbohydrates-antioxidant-activity-and-%C3%AE-amylase-inhibition-in-pulse-flours
#4
Nadia Moussou, Marta Corzo-Martínez, María Luz Sanz, Farid Zaidi, Antonia Montilla, Mar Villamiel
In this paper, the quality of bean, chickpea, fava beans, lentil and pea flours from Algeria has been evaluated. Maillard reaction (MR) indicators, modifications in the carbohydrate and protein fractions, antioxidant activity and α-amylase inhibitor of raw, toasted and stored samples were evaluated. Fava beans, beans and peas showed higher content of raffinose family oligosaccharides while chickpeas and lentils showed higher polyol content. Toasting and storage caused slightly change in pulse quality; MR showed slight losses of lysine but increased antioxidant activity...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28299616/promise-of-sglt2-inhibitors-in-heart-failure-diabetes-and-beyond
#5
REVIEW
Pieter Martens, Chantal Mathieu, Frederik H Verbrugge
This review provides mechanistic insight in the pleiotropic effects of sodium-glucose transporter-2 (SGLT-2) inhibitors with particular interest to the pathophysiology of heart failure. The SGLT-2 inhibitor empagliflozin has recently demonstrated an unprecedented 38% reduction in cardiovascular mortality in patients with diabetes. Despite modest effects on long-term glycemic control, highly significant reductions in heart failure admissions and end-stage kidney disease were observed. SGLT-2 inhibitors are the latest approved class of glucose-lowering agents...
March 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28292654/vinegar-consumption-can-attenuate-postprandial-glucose-and-insulin-responses-a-systematic-review-and-meta-analysis-of-clinical-trials
#6
REVIEW
Farideh Shishehbor, Anahita Mansoori, Fatemeh Shirani
OBJECTIVE: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results. RESEARCH METHODS AND PROCEDURES: The purpose of the current study was to systematically review control trials that report on the effect of vinegar intake on postprandial glucose response. Postprandial insulin response was considered as secondary outcome...
March 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28289653/efficacy-of-low-and-moderate-intensity-statins-for-achieving-low-density-lipoprotein-cholesterol-targets-in-thai-type-2-diabetic-patients
#7
Nuntakorn Thongtang, Chaiyut Sitthananun, Sutin Sriussadaporn, Wannee Nitiyanant
BACKGROUND: Low dose statins are commonly used among Asians, because plasma low-density lipoprotein cholesterol (LDL-C) reductions similar to those observed in Westerners are achieved at lower doses. We aimed to assess the efficacy of low- and moderate-intensity statins for achieving plasma lipid targets in Thai type2 diabetes (T2D) and to evaluate factors associated with greater LDL-C reduction by statins. METHODS: T2D patients who were treated with low- and moderate-intensity statins at the Siriraj Diabetes Clinic during the January 2013 to December 2014 study period were eligible for inclusion(n = 978), 400 patients were randomly recruited...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28284945/fish-oil-prevents-rodent-anxious-states-comorbid-with-diabetes-a-putative-involvement-of-nitric-oxide-modulation
#8
Isadora Pozzetti Siba, Mariza Bortolanza, Maria Aparecida Barbato Frazão Vital, Roberto Andreatini, Joice Maria da Cunha, Elaine Aparecida Del Bel, Janaína Menezes Zanoveli
There is an urgent need to understand the pathophysiological mechanisms related to anxiety associated with diabetes, seeking more effective alternative treatments to treat it. For that, the effect of a preventive and prolonged treatment with fish oil (FO), a source of omega-3 polyunsaturated fatty acid, was tested in streptozotocin-diabetic (DBT) rats submitted to the anxiety tests. Additionally, an immunohistochemistry for neuronal NO synthase (nNOS) was performed in brain areas related to anxiety, such as lateral amygdala (AMY), hippocampus (HIP) and dorsolateral periaqueductal gray (dlPAG)...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28283863/clinical-and-metabolic-response-to-vitamin-d-supplementation-in-endometrial-hyperplasia-a-randomized-double-blind-placebo-controlled-trial
#9
Zohreh Tabassi, Sedigheh Bagheri, Mansooreh Samimi, Hamid Reza Gilasi, Fereshteh Bahmani, Maryam Chamani, Zatollah Asemi
There was inconsistent evidence showing that vitamin D intake may be associated with reduced cancer risk due to optimized metabolic profile and reduced oxidative stress. However, we are not aware of any study evaluating the effects of vitamin D supplementation on clinical response and metabolic status of patients with endometrial hyperplasia (EH). This research was done to evaluate the effects of vitamin D supplementation on clinical response and metabolic status of patients with EH. This randomized, double-blind, placebo-controlled trial was conducted among 60 women diagnosed with EH...
March 10, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28273870/a-high-fiber-cookie-made-with-resistant-starch-type-4-reduces-post-prandial-glucose-and-insulin-responses-in-healthy-adults
#10
Maria L Stewart, J Paul Zimmer
Distarch phosphate is a resistant starch type 4 (RS4) containing phosphodiester cross-links within and between starch molecules. This study examined the glycemic effects of VERSAFIBE 1490™ resistant starch, a distarch phosphate derived from potato, containing 90% total dietary fiber (TDF, AOAC 991.43 method). In this double-blind, randomized, placebo-controlled, cross-over study, 28 healthy adults consumed a cookie containing 24 g fiber from distarch phosphate (fiber cookie) or a control cookie containing 0...
March 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28265415/metabolic-improvements-following-roux-en-y-surgery-assessed-by-solid-meal-test-in-subjects-with-short-duration-type-2-diabetes
#11
Sudha S Shankar, Lori A Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J Acton, RoseMarie Jones, Samer G Mattar, Deborah L Miller, Lea Petry, Chan R Beals, S Aubrey Stoch, David E Kelley, Robert V Considine
BACKGROUND: Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance tests (MMTT). Few studies have evaluated the glycemic and hormonal response to a solid mixed meal in subjects with diabetes prior to, and within the first month following RYGB. METHODS: Seventeen women with type 2 diabetes of less than 5 years duration participated...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28261040/changes-in-cerebral-blood-flow-during-an-alteration-in-glycemic-state-in-a-large-non-human-primate-papio-hamadryas-sp
#12
Peter Kochunov, Hsiao-Ying Wey, Peter T Fox, Jack L Lancaster, Michael D Davis, Danny J J Wang, Ai-Ling Lin, Raul A Bastarrachea, Marcia C R Andrade, Vicki Mattern, Patrice Frost, Paul B Higgins, Anthony G Comuzzie, Venkata S Voruganti
Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28259008/glucose-patterns-during-the-ogtt-and-risk-of-future-diabetes-in-an-urban-indian-population-the-carrs-study
#13
Adam Hulman, Unjali P Gujral, K M Venkat Narayan, Rajendra Pradeepa, Deepa Mohan, Ranjit Mohan Anjana, Viswanathan Mohan, Kristine Færch, Daniel R Witte
AIMS: Traditionally, fasting and 2-hour post challenge plasma glucose have been used to diagnose diabetes. However, evidence indicates that clinically relevant pathophysiological information can be obtained by adding intermediate time-points to a standard oral glucose tolerance test (OGTT). METHODS: We studied a population-based sample of 3666 Asian Indians without diabetes from the CARRS-Chennai Study, India. Participants underwent a three-point (fasting, 30-min, and 2-h) OGTT at baseline...
February 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28254842/%C3%AE-cell-inactivation-of-gpr119-unmasks-incretin-dependence-of-gpr119-mediated-glucoregulation
#14
Brandon L Panaro, Grace B Flock, Jonathan E Campbell, Jacqueline L Beaudry, Xiemin Cao, Daniel J Drucker
GPR119 was originally identified as an orphan β-cell receptor however subsequent studies demonstrated that GPR119 also regulates β-cell function indirectly through incretin hormone secretion. We assessed the importance of GPR119 for β-cell function in Gpr119(-/-) mice and in newly generated Gpr119(βcell-/-) mice. Gpr119(-/-) mice displayed normal body weight and glucose tolerance on a regular chow diet. After high fat feeding, Gpr119(-/-) mice exhibited reduced fat mass, decreased levels of circulating adipokines, improved insulin sensitivity and better glucose tolerance...
March 2, 2017: Diabetes
https://www.readbyqxmd.com/read/28254632/metabolic-and-inflammatory-responses-to-the-common-sweetener-stevioside-and-a-glycemic-challenge-in-horses-with-equine-metabolic-syndrome
#15
S E Elzinga, B Rohleder, B Schanbacher, K McQuerry, V D Barker, A A Adams
Extracts derived from the leaves of the stevia plant (stevioside) are commonly used as sweeteners for humans and horses. Stevioside appears to be safe for human consumption, including for individuals with insulin dysregulation. In the horse, the safety or metabolic effects of stevioside on normal animals or on those with metabolic dysfunction are unknown. Furthermore, the inflammatory response to a glycemic challenge or to stevioside in horses is not well defined. Therefore, the objective of this study was to measure the effects of stevioside and a glycemic challenge on insulin, glucose, and inflammatory responses in horses with a common metabolic dysfunction (equine metabolic syndrome or EMS) compared with non-EMS controls...
February 4, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28254195/bdnf-and-ampa-receptors-in-the-cnts-modulate-the-hyperglycemic-reflex-after-local-carotid-body-nacn-stimulation
#16
R Cuéllar, S Montero, S Luquín, J García-Estrada, V Melnikov, A Virgen-Ortiz, M Lemus, M Pineda-Lemus, E de Álvarez-Buylla
The application of sodium cyanide (NaCN) to the carotid body receptors (CBR) (CBR stimulation) induces rapid blood hyperglycemia and an increase in brain glucose retention. The commissural nucleus tractus solitarius (cNTS) is an essential relay nucleus in this hyperglycemic reflex; it receives glutamatergic afferents (that also release brain derived neurotrophic factor, BDNF) from the nodose-petrosal ganglia that relays CBR information. Previous work showed that AMPA in NTS blocks hyperglycemia and brain glucose retention after CBR stimulation...
February 3, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28250848/tissue-specific-methylation-profile-in-obese-patients-with-type-2-diabetes-before-and-after-roux-en-y-gastric-bypass
#17
REVIEW
Priscila Sala, Raquel Susana Matos de Miranda Torrinhas, Danielle Cristina Fonseca, Graziela Rosa Ravacci, Dan Linetzky Waitzberg, Daniel Giannella-Neto
Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of genes, including genes related to glycemic control, at any stage of life. The epigenetic mechanism underlying obesity and T2D pathogenesis remains poorly understood. Conventional strategies for the treatment of obesity and its comorbidities often have poor long-term adherence, and pharmacological interventions are limited...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28250646/antihyperglycemic-activity-of-the-leaves-from-annona-cherimola-miller-and-rutin-on-alloxan-induced-diabetic-rats
#18
Fernando Calzada, Jesús Iván Solares-Pascasio, R M Ordoñez-Razo, Claudia Velazquez, Elizabeth Barbosa, Normand García-Hernández, David Mendez-Luna, José Correa-Basurto
BACKGROUND: Annona cherimola, known as "chirimoya" has been reported in Mexican traditional medicine for the treatment of diabetes. OBJECTIVE: The aims of the present study were to validate and assess the traditional use of A. cherimola as an antidiabetic agent. MATERIALS AND METHODS: The ethanol extract from A. cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28244792/effects-unrelated-to-anti-inflammation-of-lipid-emulsions-containing-fish-oil-in-parenteral-nutrition-for-adult-patients
#19
Javier Mateu de Antonio, Marta Florit-Sureda
Several reviews and meta-analyses on modulated inflammatory and immunologic responses after the administration of omega-3 polyunsaturated fatty acids (PUFAs) in different diseases and conditions have been published. However, omega-3 PUFAs exert several other actions which are not directly related to immunologic or inflammatory responses. The aim of this paper was to review the effects which are not directly related to immunologic and inflammatory responses of intravenous lipid emulsions (IVLEs) containing fish oil (FO) in parenteral nutrition (PN) for adult patients...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28236380/my-sweetheart-is-broken-role-of-glucose-in-diabetic-cardiomyopathy
#20
REVIEW
Manoja K Brahma, Mark E Pepin, Adam R Wende
Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory...
February 2017: Diabetes & Metabolism Journal
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