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https://www.readbyqxmd.com/read/28182518/clinical-evaluation-of-a-bioactive-beta-glucan-gel-in-the-treatment-of-hard-to-heal-wounds
#1
B King, S Barrett, K F Cutting
OBJECTIVE: The aim of this evaluation is to assess the effects of a wound healing gel in a wounds of different aetiologies. METHOD: Data was recorded on the wound surface area, tissue type, and patient level of wound pain at baseline (0) and at weeks 1, 2, 3, 4, and 8. RESULTS: Of the total 39 patients enrolled in the study, 26 patients who complied with the protocol criteria completed the minimum four-week study period. During the 12-week evaluation period, seven of the 26 wounds fully healed and an additional eight wounds showed a reduction in size of more than 50 %...
February 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28107445/beta-glucans-supplementation-associates-with-reduction-in-p-cresyl-sulfate-levels-and-improved-endothelial-vascular-reactivity-in-healthy-individuals
#2
Carmela Cosola, Maria De Angelis, Maria Teresa Rocchetti, Eustacchio Montemurno, Valentina Maranzano, Giuseppe Dalfino, Carlo Manno, Annapaola Zito, Michele Gesualdo, Marco Matteo Ciccone, Marco Gobbetti, Loreto Gesualdo
BACKGROUND: Oat and barley beta-glucans are prebiotic fibers known for their cholesterol-lowering activity, but their action on the human gut microbiota metabolism is still under research. Although the induction of short-chain fatty acids (SCFA) following their ingestion has previously been reported, no study has investigated their effects on proteolytic uremic toxins p-cresyl sulfate (pCS) and indoxyl sulfate (IS) levels, while others have failed to demonstrate an effect on the endothelial function measured through flow-mediated dilation (FMD)...
2017: PloS One
https://www.readbyqxmd.com/read/27999319/exercise-and-beta-glucan-consumption-saccharomyces-cerevisiae-improve-the-metabolic-profile-and-reduce-the-atherogenic-index-in-type-2-diabetic-rats-hfd-stz
#3
Eric Francelino Andrade, Andressa Ribeiro Veiga Lima, Ingrid Edwiges Nunes, Débora Ribeiro Orlando, Paula Novato Gondim, Márcio Gilberto Zangeronimo, Fernando Henrique Ferrari Alves, Luciano José Pereira
Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan (Saccharomyces cerevisiae) consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats...
December 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27951636/adjuvant-activity-enhanced-by-cross-linked-cpg-oligonucleotides-in-%C3%AE-glucan-nanogel-and-its-antitumor-effect
#4
Noriko Miyamoto, Shinichi Mochizuki, Shota Fujii, Kenta Yoshida, Kazuo Sakurai
Cancer vaccine has the ability to directly eradicate tumor cells by creating and activating cytotoxic T lymphocytes (CTLs). To achieve efficient CTL activity and to induce Th1 responses, it is essential to administer an appropriate adjuvant as well as an antigen. CpG-ODN is known as a ligand of Toll-like receptor 9 (TLR9) and strongly induces Th1 responses. In our previous study, we developed a CpG-ODN delivery system by use of the formation of complexes between ODN and a β-glucan SPG, denoted as CpG/SPG, and demonstrated that CpG/SPG induces high Th1 responses...
January 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27814595/particulate-beta-glucan-induces-early-and-late-phagosomal-maturation-in-murine-macrophages
#5
Nida Fatima, Tarun Upadhyay, Deepak Sharma, Rolee Sharma
Beta-glucans are carbohydrates (glucose polymers) found in the cell walls of fungi, yeast, algae, lichens, and plants such as oats and barley. Beta-glucans bind to glucan receptor on phagocytic cells and modify these cells to become "immunologically active" by generating a variety of innate immune responses. Particulate beta-glucan has been specifically shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS)...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27769933/the-impact-of-germination-time-on-the-some-selected-parameters-through-malting-process
#6
Vahid Farzaneh, Alireza Ghodsvali, Hamid Bakhshabadi, Zahra Zare, Isabel S Carvalho
In the present study, the impacts of germination time on the enzymes activity attributed in malting and some polysaccharides contents of the malt prepared from the Joseph barley variety have been screened using a completely random design with three levels of germination time(3, 5 and 7days). The archived outcomes revealed that the highest quantity of starch has been observed in the malt resulted from 3days germination, and an enhancement in the germination period from 3 to 7days decreased the quantity of available starch...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27756305/bcsz-inhibits-biofilm-phenotypes-and-promotes-virulence-by-blocking-cellulose-production-in-salmonella-enterica-serovar-typhimurium
#7
Irfan Ahmad, Syed Fazle Rouf, Lei Sun, Annika Cimdins, Sulman Shafeeq, Soazig Le Guyon, Marco Schottkowski, Mikael Rhen, Ute Römling
BACKGROUND: Cellulose, a 1,4 beta-glucan polysaccharide, is produced by a variety of organisms including bacteria. Although the production of cellulose has a high biological, ecological and economical impact, regulatory mechanisms of cellulose biosynthesis are mostly unknown. Family eight cellulases are regularly associated with cellulose biosynthesis operons in bacteria; however, their function is poorly characterized. In this study, we analysed the role of the cellulase BcsZ encoded by the bcsABZC cellulose biosynthesis operon of Salmonella enterica serovar Typhimurium (S...
October 19, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27749909/a-new-membrane-protein-sbg1-links-the-contractile-ring-apparatus-and-septum-synthesis-machinery-in-fission-yeast
#8
Kriti Sethi, Saravanan Palani, Juan C G Cortés, Mamiko Sato, Mayalagu Sevugan, Mariona Ramos, Shruthi Vijaykumar, Masako Osumi, Naweed I Naqvi, Juan Carlos Ribas, Mohan Balasubramanian
Cytokinesis in many organisms requires a plasma membrane anchored actomyosin ring, whose contraction facilitates cell division. In yeast and fungi, actomyosin ring constriction is also coordinated with division septum assembly. How the actomyosin ring interacts with the plasma membrane and the plasma membrane-localized septum synthesizing machinery remains poorly understood. In Schizosaccharomyces pombe, an attractive model organism to study cytokinesis, the β-1,3-glucan synthase Cps1p / Bgs1p, an integral membrane protein, localizes to the plasma membrane overlying the actomyosin ring and is required for primary septum synthesis...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27677198/effects-of-beta-glucan-on-protection-of-young-and-aged-rats-from-renal-ischemia-and-reperfusion-injury
#9
M Esrefoglu, O E Tok, M S Aydin, M Iraz, O F Ozer, S Selek, M Iraz
BACKGROUND: Ischemia-reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. β-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of β-glucan against renal ischemia-reperfusion injury comparatively in young and aged rats...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27604040/development-of-downstream-processing-to-minimize-beta-glucan-impurities-in-gmp-manufactured-therapeutic-antibodies
#10
Kim Vigor, John Emerson, Robert Scott, Julia Cheek, Claire Barton, Heather J Bax, Debra H Josephs, Sophia N Karagiannis, James F Spicer, Heike Lentfer
The presence of impurities or contaminants in biological products such as monoclonal antibodies (mAb) could affect efficacy or cause adverse reactions in patients. ICH guidelines (Q6A and Q6B) are in place to regulate the level of impurities within clinical drug products. An impurity less often reported and, therefore, lacking regulatory guideline is beta-glucan. Beta-glucans are polysaccharides of d-glucose monomers linked by (1-3) beta-glycosidic bonds, and are produced by prokaryotic and eukaryotic organisms, including plants...
November 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27596390/screening-of-beta-glucan-contents-in-commercially-cultivated-and-wild-growing-mushrooms
#11
Miriam Sari, Alexander Prange, Jan I Lelley, Reinhard Hambitzer
Mushrooms have unique sensory properties and nutritional values as well as health benefits due to their bioactive compounds, especially beta-glucans. Well-known edible and medicinal mushroom species as well as uncommon or unknown species representing interesting sources of bioactive beta-glucans have been widely studied. Commercially cultivated and wild growing mushrooms were analysed for their beta-glucan contents. Enzymatic determinations of all glucans, alpha-glucans and beta-glucans in 39 mushrooms species were performed, leading to very remarkable results...
February 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27566177/shiitake-mushroom-dermatitis-a-review
#12
REVIEW
Mathew Paul Stephany, Stella Chung, Marc Zachary Handler, Nancy Stefanie Handler, Glenn A Handler, Robert A Schwartz
Shiitake mushroom dermatitis is a cutaneous reaction caused by the consumption of raw or undercooked shiitake mushrooms. Symptoms include linear erythematous eruptions with papules, papulovesicles or plaques, and severe pruritus. It is likely caused by lentinan, a heat-inactivated beta-glucan polysaccharide. Cases were initially reported in Japan but have now been documented in other Asian countries, North America, South America, and Europe, as this mushroom is now cultivated and consumed worldwide. Shiitake mushroom dermatitis may result from mushroom ingestion or from handling, which can result in an allergic contact dermatitis...
October 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27565144/the-effect-of-a-newly-developed-oat-banana-fermented-beverage-with-a-beta-glucan-additive-on-ldhl-gene-expression-in-streptococcus-thermophilus-tkm3-kkp-2030p
#13
Anna Goncerzewicz, Anna Misiewicz, Lubomiła Owczarek, Urszula Jasińska, Sylwia Skąpska
The number of people who cannot consume dairy products due to intolerance or allergies to food components is increasing. Consumers are increasingly searching for alternative, nondairy beverages which have an advantageous effect on the body and which stimulate gut microflora. Previous studies have shown that Streptococcus thermophilus TKM3 KKP 2030p can be an efficient starter culture for the fermentation of plant material and can also ensure an acceptable sensory profile and a high number of lactic acid bacteria during 4 week cold storage...
December 2016: Current Microbiology
https://www.readbyqxmd.com/read/27558179/cerebrospinal-fluid-1-3-beta-d-glucan-testing-is-useful-in-diagnosis-of-coccidioidal-meningitis
#14
David A Stevens, Yonglong Zhang, Malcolm A Finkelman, Demosthenes Pappagianis, Karl V Clemons, Marife Martinez
Diagnosing coccidioidal meningitis (CM) can be problematic owing to its infrequency and/or a delay in the positivity of a cerebrospinal fluid (CSF) culture or CSF antibody, particularly if the primary coccidioidal infection is unrecognized. We tested 37 CSF specimens, 26 from patients with confirmed CM and 11 from patients with suspected microbial meningitis without fungal diagnosis, for (1,3)-beta-glucan (BG). BG in CM CSF specimens ranged from 18 to 3,300 pg/ml and in controls ranged from <3.9 to 103 pg/ml...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27473075/beta-glucan-contamination-of-pharmaceutical-products-how-much-should-we-accept
#15
REVIEW
Claire Barton, Kim Vigor, Robert Scott, Paul Jones, Heike Lentfer, Heather J Bax, Debra H Josephs, Sophia N Karagiannis, James F Spicer
Beta-glucans are large polysaccharides produced by a range of prokaryotic and eukaryotic organisms. They have potential immunostimulatory properties and have been used with therapeutic intent as anti-microbial and anti-tumour agents. A range of other potentially beneficial effects have been described, and oral forms of beta-glucans are widely available over-the-counter and online. Parenteral formulations are popular in parts of Asia and are the subject of ongoing trials, worldwide. Beta-glucans are also potential contaminants of pharmaceutical products, and high levels have been described in some blood products...
November 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27462331/qtl-mapping-by-slaf-seq-and-expression-analysis-of-candidate-genes-for-aphid-resistance-in-cucumber
#16
Danna Liang, Minyang Chen, Xiaohua Qi, Qiang Xu, Fucai Zhou, Xuehao Chen
Cucumber, a very important vegetable crop worldwide, is easily damaged by pests. Aphid is one of the most serious cucumber pests and frequently cause severe damage to commercially produced crops. Understanding the genetic mechanisms underlying pest resistance is important for aphid-resistant cucumber varieties breeding. In this study, two parental cucumber lines, JY30 (aphid susceptible) and EP6392 (aphid resistant), and pools of resistant and susceptible (n = 50 each) plants from 1000 F2 individuals derived from crossing JY30 with EP6392, were used to detect genomic regions associated with aphid resistance in cucumbers...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27442590/royal-decree-gene-expression-in-trans-generationally-immune-primed-bumblebee-workers-mimics-a-primary-immune-response
#17
Seth M Barribeau, Paul Schmid-Hempel, Ben M Sadd
Invertebrates lack the cellular and physiological machinery of the adaptive immune system, but show specificity in their immune response and immune priming. Functionally, immune priming is comparable to immune memory in vertebrates. Individuals that have survived exposure to a given parasite are better protected against subsequent exposures. Protection may be cross-reactive, but demonstrations of persistent and specific protection in invertebrates are increasing. This immune priming can cross generations ("trans-generational" immune priming), preparing offspring for the prevailing parasite environment...
2016: PloS One
https://www.readbyqxmd.com/read/27411887/lentinan-modified-carbon-nanotubes-as-an-antigen-delivery-system-modulate-immune-response-in-vitro-and-in-vivo
#18
Jie Xing, Zhenguang Liu, Yifan Huang, Tao Qin, Ruonan Bo, Sisi Zheng, Li Luo, Yee Huang, Yale Niu, Deyun Wang
Adjuvants enhance immunogenicity and sustain long-term immune responses. As vital components of vaccines, efficient adjuvants are highly desirable. Recent evidence regarding the potential of carbon nanotubes (CNTs) to act as a support material has suggested that certain properties, such as their unique hollow structure, high specific surface area, and chemical stability, make CNTs desirable for a variety of antigen-delivery applications. Lentinan, a β-1,3-glucohexaose with β-1,6-branches that is extracted from the mushroom Lentinus edodes, is an effective immunostimulatory drug that has been clinically used in Japan and China, and recent studies have proved that specific beta-glucans can bind to various immune receptors...
August 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27339320/improvement-of-immune-responses-to-influenza-vaccine-h5n1-by-sulfated-yeast-beta-glucan
#19
Mi Wang, Lifang Zhang, Ruile Yang, Chenzhong Fei, Xiaoyang Wang, Keyu Zhang, Chunmei Wang, Wenli Zheng, Feiqun Xue
In this study, the adjuvant activity of sulfated glucan from saccharomyces cerevisiae (SGSC) was investigated. sGSC had molecular weight of 12.9kDa and degrees of sulfation of 0.16. The effects of SGSC on the splenic lymphocyte cells of mice were measured in vitro. The results showed that SGSC could significantly promote lymphocyte proliferation singly or synergistically with Con A and LPS, and stimulate the cells to secrete IL-2 and INF-γ. The adjuvant activity of SGSC was researched in BALB/c mice inoculated with inactivated H5N1vaccine in vivo...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27311684/genotoxicity-and-subchronic-toxicity-evaluation-of-dried-euglena-gracilis-atcc-pta-123017
#20
Ryan R Simon, Trung D Vo, Robert Levine
Euglena gracilis is a microalga capable of synthesizing various nutrients of interest in human and animal nutrition. When cultivated aerobically in the dark, Euglena synthesize paramylon, a storage polysaccharide comprised of high molecular weight beta-1,3-D-glucose polymers organized in cytoplasmic granules. Beta-glucans have been shown to have immune modulation effects, including anti-microbial, anti-tumor, and anti-oxidant properties, and metabolic effects, such as regulation of cholesterol and blood sugar levels...
October 2016: Regulatory Toxicology and Pharmacology: RTP
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