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https://www.readbyqxmd.com/read/27911767/phosphatidylinositol-3-kinase-inhibition-restores-ca2-release-defects-and-prolongs-survival-in-myotubularin-deficient-mice
#1
Candice Kutchukian, Mirella Lo Scrudato, Yves Tourneur, Karine Poulard, Alban Vignaud, Christine Berthier, Bruno Allard, Michael W Lawlor, Ana Buj-Bello, Vincent Jacquemond
Mutations in the gene encoding the phosphoinositide 3-phosphatase myotubularin (MTM1) are responsible for a pediatric disease of skeletal muscle named myotubular myopathy (XLMTM). Muscle fibers from MTM1-deficient mice present defects in excitation-contraction (EC) coupling likely responsible for the disease-associated fatal muscle weakness. However, the mechanism leading to EC coupling failure remains unclear. During normal skeletal muscle EC coupling, transverse (t) tubule depolarization triggers sarcoplasmic reticulum (SR) Ca(2+) release through ryanodine receptor channels gated by conformational coupling with the t-tubule voltage-sensing dihydropyridine receptors...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27896587/psychological-and-behavioral-issues-in-the-management-of-migraine-in-children-and-adolescents
#2
REVIEW
William Qubty, Amy A Gelfand
PURPOSE OF REVIEW: It is sometimes assumed that children and adolescents with migraine have a psychiatric or behavioral comorbidity, a belief that can be stigmatizing. This review will examine the recent literature addressing this area to determine if pediatric and adolescent migraineurs are at increased risk for psychiatric comorbidity and to discuss management strategies. RECENT FINDINGS: A large systematic review of pediatric and adolescent studies concluded anxiety and depression were not associated with onset of recurrent headaches...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27889401/clinical-and-psychosocial-outcomes-of-a-structured-transition-program-among-young-adults-with-type-1-diabetes
#3
Elizabeth A Pyatak, Paola A Sequeira, Cheryl L P Vigen, Marc J Weigensberg, Jamie R Wood, Lucy Montoya, Valerie Ruelas, Anne L Peters
PURPOSE: We identified and treated young adults with type 1 diabetes who had been lost to follow-up during their transfer from pediatric to adult care, comparing their clinical, psychosocial, and health care utilization outcomes to participants receiving continuous care (CC) throughout the transition to adult care. METHODS: Individuals in their last year of pediatric care (CC group, n = 51) and individuals lost to follow-up in the transfer to adult care ("lapsed care" [LC] group, n = 24) were followed prospectively for 12 months...
November 23, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27872354/integrating-maternal-mental-health-care-in-the-pediatric-medical-home-treatment-engagement-and-child-outcomes
#4
Mary C Kimmel, Rheanna E Platt, Danielle N Steinberg, Fallon Cluxton-Keller, Lauren M Osborne, Tracy Carter, Jennifer L Payne, Barry S Solomon
Maternal depression is associated with an array of poor child health outcomes, and low-income women face many barriers to accessing treatment. In this pilot study, we assessed treatment engagement in a maternal mental health clinic staffed by a case manager and psychiatrist in an urban pediatric practice. We also examined factors associated with engagement as well as child health outcomes and health care use. Nearly half of the women enrolled attended at least 4 sessions with a psychiatrist in 6 months. Text messaging with the case manager was associated with a greater compliance with psychiatrist sessions...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27869780/the-parent-psychological-flexibility-questionnaire-ppfq-item-reduction-and-validation-in-a-clinical-sample-of-swedish-parents-of-children-with-chronic-pain
#5
Camilla Wiwe Lipsker, Marie Kanstrup, Linda Holmström, Mike Kemani, Rikard K Wicksell
In pediatric chronic pain, research indicates a positive relation between parental psychological flexibility (i.e., the parent's willingness to experience distress related to the child's pain in the service of valued behavior) and level of functioning in the child. This points to the utility of targeting parental psychological flexibility in pediatric chronic pain. The Parent Psychological Flexibility Questionnaire (PPFQ) is currently the only instrument developed for this purpose, and two previous studies have indicated its reliability and validity...
November 19, 2016: Children
https://www.readbyqxmd.com/read/27868277/outpatient-antidepressant-drug-use-in-children-and-adolescents-in-germany-between-2004-and-2011
#6
Carsten Schröder, Michael Dörks, Bianca Kollhorst, Tilo Blenk, Ralf W Dittmann, Edeltraut Garbe, Oliver Riedel
PURPOSE: Recent studies on the utilization of antidepressant drugs in minors are scarce, methodologically limited, and do not factor in off-label use sufficiently. Beyond that, little is known about the short treatment durations that have been observed for many young antidepressant users. The present study examined antidepressant use in pediatric patients aged 0 to 17 years over time, investigated changes regarding the prescribed drugs, analyzed underlying diagnoses, and assessed the rate of off-label use...
November 20, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27866918/-children-and-adolescents-anxiety-disorders
#7
H Denis, A Baghdadli
Anxiety disorders were long underestimated in children by healthcare professionals, but they are now better diagnosed. They account for the most frequent psychiatric diagnosis between 6 and 18 years of age, with differences in prevalence or risk factors related to the clinical forms. Different clinical subtypes of anxiety disorders are detailed in this article: separation anxiety, specific phobia, generalized anxiety, social anxiety, panic disorder, post-traumatic stress syndrome, and obsessional-compulsive disorder...
November 17, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27863276/simplest-radiological-measurement-related-to-clinical-success-in-endoscopic-third-ventriculostomy
#8
Alp Özgün Börcek, Murat Uçar, Burak Karaaslan
OBJECTIVE: Radiologic criteria for a successful endoscopic third ventriculostomy are not clearly defined and there is an ongoing need for determining simplest and strongest radiological criteria for this purpose. This paper aims to determine the easiest radiological parameter related to surgical outcome METHODS: Between January 2012 and December 2015 all patients receiving endoscopic third ventriculostomy with various indications were reviewed and 29 patients whose preoperative and early postoperative 3D-CISS images were available were studied...
November 12, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27856605/medically-hospitalized-patients-with-eating-disorders-and-somatoform-disorders-in-pediatrics-what-are-their-similarities-and-differences-and-how-can-we-improve-their-care
#9
Patricia Ibeziako, Jennifer M Rohan, Simona Bujoreanu, Christine Choi, Meghan Hanrahan, Melissa Freizinger
OBJECTIVES: The purpose of the current study is to describe the demographic and clinical characteristics and health care use of medically hospitalized patients with eating disorders (ED) and somatoform disorders (SFD) in a pediatric setting and to use the findings to explore opportunities for improved care. METHODS: Retrospective chart reviews of 125 patients with SFD and 125 patients with ED (N = 250) seen at a tertiary pediatric facility over a 12- and 19-month period, respectively...
December 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/27855438/how-to-prevent-depression-current-directions-and-future-challenges-in-children-with-chronic-medical-conditions
#10
Anna Felnhofer, Oswald D Kothgassner, Claudia Klier
With its high rates of chronicity and concomitant economic costs to society, depression ranges among the most prevalent mental disorders. Several trials have succeeded in demonstrating the beneficial effects of early depression prevention programs for otherwise healthy children and adolescents. However, comparable programs for children and adolescents with a medical condition are still scarce. This paper discusses the situation of chronically ill children and adolescents who are at risk of developing comorbid depressive symptoms using the example of three conditions frequently encountered in pediatric psychosomatic medicine: diabetes, epilepsy and inflammatory bowel disease (IBD)...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27854323/a-clinical-pilot-study-of-individual-and-group-treatment-for-adolescents-with-chronic-pain-and-their-parents-effects-of-acceptance-and-commitment-therapy-on-functioning
#11
Marie Kanstrup, Rikard K Wicksell, Mike Kemani, Camilla Wiwe Lipsker, Mats Lekander, Linda Holmström
Pediatric chronic pain is common and can result in substantial long-term disability. Previous studies on acceptance and commitment therapy (ACT) have shown promising results in improving functioning in affected children, but more research is still urgently needed. In the current clinical pilot study, we evaluated an ACT-based interdisciplinary outpatient intervention (14 sessions), including a parent support program (four sessions). Adolescents were referred to the clinic if they experienced disabling chronic pain...
November 16, 2016: Children
https://www.readbyqxmd.com/read/27852818/parents-acute-illnesses-hospitalizations-and-medication-changes-during-the-difficult-first-year-after-infant-or-child-nicu-picu-death
#12
Dorothy Brooten, JoAnne M Youngblut, Carmen Caicedo, Teresa Del Moral, G Patricia Cantwell, Balagangadhar Totapally
BACKGROUND AND OBJECTIVES: Infant/child death is described as a most stressful life event; however, there are few reports of effects on parent physical health during the first year after the death. The study's purpose is to examine the patterns of parent acute illnesses, hospitalizations, and medication changes over 1 to 13 months after neonatal intensive care unit (NICU) or pediatric intensive care unit (PICU) infant/child death in 3 racial/ethnic groups. METHODS: Secondary analyses were conducted with longitudinal data on parent health and functioning 1 to 13 months after infant/child NICU/PICU death...
November 15, 2016: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/27847704/treatment-of-postoperative-pain-in-pediatric-operations-comparing-the-efficiency-of-bupivacaine-bupivacaine-dexmedetomidine-and-bupivacaine-fentanyl-for-caudal-block
#13
Hashem Jarineshin, Fereydoon Fekrat, Aida Kargar Kermanshah
BACKGROUND: Caudal analgesia is a common method for postoperative pain management in pediatric patients. Additive agents such as opioids and α2 agonists have been used to enhance the analgesic effects of local anesthetics for caudal block. OBJECTIVES: The aim of this study was to compare the additive effects of dexmedetomidine and fentanyl on bupivacaine-induced caudal analgesia in pediatric patients who had undergone elective inguinal hernia repair. METHODS: This randomized, double-blind clinical trial included children aged 1 - 5 years who were divided into three groups: the bupivacaine group (Group B) received 0...
October 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27843858/clinical-study-of-burn-patients-requiring-admission-a-single-center-experience-at-north-eastern-indira-gandhi-regional-institute-of-health-and-medical-sciences
#14
Donkupar Khongwar, Ranendra Hajong, Jyoutishman Saikia, Noor Topno, Arup J Baruah, Ojing Komut
BACKGROUND: Although burns are a major problem in health care, a lot of the variation in risk factors exists from region to region which if uncovered correctly could help take effective prevention measures. AIMS AND OBJECTIVES: To assess the 3-year (January 2012 to January 2015) epidemiology of burn injuries admitted to our hospital (primary objective) and to find areas of improvement in burn care (secondary objective). MATERIALS AND METHODS: After obtaining ethical approval data were obtained from the medical record section regarding age, sex, residence, occupation, marital status, socioeconomic status, dates of admission and discharge, circumstances regarding the place, intent, cause, and source of heat...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843467/comparison-of-relation-between-attention-deficit-hyperactivity-disorder-in-children-with-and-without-simple-febrile-seizure-admitted-in-arak-central-iran
#15
Bahman Salehi, Parsa Yousefichaijan, Smira Safi Arian, Somaieh Ebrahimi, Mahdyieh Naziri
OBJECTIVE: Febrile seizure is one of the most prevalent childhood convulsions with the most common age of onset at 14-18 mo old. Fever decreases the brain threshold for seizure. Attention Deficit Hyperactivity Disorder (ADHD) is also a neurologic-behavioral problem defined by attention deficit and hyperactivity according to DSM-IV criteria in which the child must have these signs in two different environments. There is controversy on the possible relation between febrile seizure and ADHD; while some studies approve a strong relation, some exclude any relation and some attribute ADHD to the side effects of other reasons...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27843261/autotransplantation-of-a-strange-positioned-impacted-central-incisor-in-a-surgically-prepared-socket-a-miracle-esthetic-concept
#16
Chandresh Jaiswara, Vinay K Srivastava, Neeraj Dhiman
: Esthetics is a prime concern for a young lady. Any anomaly in the anterior tooth may create anxiety and depression. This anxiety and depression may hamper her married life and overall personality. This case report reveals an unerupted right central incisor situated in a strange position, creating space in the maxillary anterior region and giving an unesthetic appearance. Autotransplantation is a method of choice for a strangely positioned impacted central incisor in a new appropriate site...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27836359/lymphocyte-depression-as-a-predictor-of-postoperative-intraabdominal-abscess-after-appendectomy-in-children
#17
Daniel L Lodwick, Jennifer N Cooper, Brian Kenney, Katherine J Deans, Peter C Minneci, Rajan K Thakkar
BACKGROUND: This study evaluated the efficacy of lymphopenia to predict postappendectomy intraabdominal abscess (IAA) in pediatric complex appendicitis. METHODS: This single-center retrospective cohort study included appendectomy patients with complex appendicitis from 4/2012 to 10/2014. IAA was diagnosed based on imaging or undergoing a drainage procedure. Labs were used from the closest day prior to abscess diagnosis or day of discharge from index admission. Lymphocyte percentage was categorized based on age-specific cutoffs with lymphopenia defined as a low percentage...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27830922/pediatric-selective-mutism-therapy-a-randomized-controlled-trial
#18
Maria Esposito, Francesca Gimigliano, Maria R Barillari, Francesco Precenzano, Maria Ruberto, Joseph Sepe, Umberto Barillari, Raffaele Gimigliano, Roberto Militerni, Giovanni Messina, Marco Carotenuto
BACKGROUND: Selective Mutism (SM) is a rare disease in children coded by DSM-5 as an anxiety disorder. Despite the disabling nature of the disease, there is still no specific treatment. AIMS: The aims of this study were to verify the efficacy of six-month standard psychomotor treatment and the positive changes in lifestyle, in a population of children affected by SM. DESIGN: Randomised Controlled Trial registered in the European Clinical Trials Registry (EuDract 2015-001161-36)...
November 10, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27824775/evaluation-of-bipolar-disorder-in-children-and-adolescents-referred-to-a-mood-service-diagnostic-pathways-and-manic-dimensions
#19
Ana P Ferreira-Maia, Alexandre C Boronat, Miguel A Boarati, Lee Fu-I, Yuan-Pang Wang
OBJECTIVES: Few studies have examined pediatric mental health services for early-onset bipolar disorder (BD). The goal of this study was to describe diagnostic pathways and manic dimensions in BD among referred children and adolescents. METHODS: Data were obtained from a review of the charts of 814 subjects, 2 to 17 years of age, with a complaint of mood disturbances who were referred between 2003 and 2012 to a university-based child and adolescent clinic that specializes in mood disorders...
November 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27818443/screening-for-parental-depression-in-urban-primary-care-practices-a-mixed-methods-study
#20
James P Guevara, Marsha Gerdes, Brooke Rothman, Victor Igbokidi, Susan Doughterty, Russell Localio, Rhonda C Boyd
We sought to determine feasibility and acceptability of parental depression screening in urban pediatric practices. We recruited seven practices to participate. Patient Health Questionnaire-2, a validated two-item screening tool, was used to screen for depressive symptoms at 1-3 year old well visits. We conducted semi-structured interviews with clinicians to identify barriers and facilitators to screening. Of 8,621 eligible parents, 21.1% completed screening with site-specific rates ranging from 10.1% to 48...
2016: Journal of Health Care for the Poor and Underserved
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