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https://www.readbyqxmd.com/read/29148866/drugs-of-abuse-and-novel-psychoactive-substances-at-outdoor-music-festivals-in-colorado
#1
Jacob Fox, Alexis Smith, Alexander Yale, Christopher Chow, Elsa Alaswad, Tracy Cushing, Andrew A Monte
BACKGROUND: Drugs of abuse (DOA) are widely used in the United States and are ubiquitous at outdoor music festivals. Attendees at music festivals are at high-risk for novel psychoactive substance (NPS) use, which is becoming more prevalent worldwide. No U.S. studies have employed an qualitative approach to investigate the etiologies of both traditional DOA and NPS use amongst music festival attendees. OBJECTIVES: The objective of this study was to improve understanding of the knowledge, attitudes, beliefs, and practices of festival attendees using NPS and DOA...
November 17, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29148814/high-yield-production-of-mos2-and-ws2-quantum-sheets-from-their-bulk-materials
#2
Chunchun Han, Yong Zhang, Peng Gao, Shulin Chen, Xinfeng Liu, Yang Mi, Jianqi Zhang, Yanhong Ma, Wenyu Jiang, Jinquan Chang
Mass production of two-dimensional quantum sheets (2D QSs) is highly desired to fully exploit their properties. Herein, we present a general strategy for the high-yield production of molybdenum disulfide (MoS2) and tungsten disulfide (WS2) QSs by a sequential combination of salt-assisted ball-milling and sonication-assisted solvent exfoliation of their bulk materials. Such strategy enables reproducible production of intrinsic and defect-free MoS2 and WS2 QSs with exceedingly high yield of 25.5 wt% and 20.1 wt% respectively...
November 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/29147840/medulloblastoma-in-adults-a%C3%A2-retrospective-single-institution-analysis
#3
Indrawati Hadi, Olarn Roengvoraphoj, Maximilian Niyazi, Falk Roeder, Ulrich Schüller, Claus Belka, Silke Birgit Nachbichler
PURPOSE: Adult medulloblastoma is a rare disease treated according to the current pediatric treatment guidelines. This retrospective analysis investigated the clinical outcomes and prognostic factors of adult medulloblastoma patients, who received multimodal therapy at our institution. METHODS: Treatment charts of all patients over the age of 15 years of age with de novo medulloblastoma, who had been treated at our institution between 2001 and 2014, were retrospectively analyzed...
November 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29143983/growth-of-doxorubicin-resistant-undifferentiated-spindle-cell-sarcoma-pdox-is-arrested-by-metabolic-targeting-with-recombinant-methioninase
#4
Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Kei Kawaguchi, Takashi Murakami, Tasuku Kiyuna, Kentaro Miyake, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
Undifferentiated spindle-cell sarcoma (USCS) is a recalcitrant -cancer in need of individualized therapy. A high-grade USCS from a striated muscle of a patient was grown orthotopically in the right biceps femoris muscle of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In a previous study, we evaluated the efficacy of standard first-line chemotherapy of doxorubicin (DOX), gemcitabine (GEM) combined with docetaxel (DOC), compared to pazopanib (PAZ), a multi-targeting tyrosine-kinase inhibitor, in an USCS PDOX model...
November 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29143056/controlling-the-length-of-self-assembled-nanotubes-by-sonication-followed-by-polymer-wrapping
#5
Mingyang Ji, Brian Daniels, Aileen Shieh, David A Modarelli, Jon R Parquette
This work demonstrates that sonication, followed by polymer-wrapping, is an effective strategy to modulate the length of self-assembled nanotubes. The length distributions of the nanotubes were controlled by varying the amplitude of sonication. Wrapping the nanotubes with ionic polymers suspended the propensity of the nanotube fragments to re-assemble over time into their elongated precursors.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29142600/co-activation-of-hedgehog-and-wnt-signaling-pathways-is-associated-with-poor-outcomes-in-triple-negative-breast-cancer
#6
Kimberly M Arnold, Ryan T Pohlig, Jennifer Sims-Mourtada
Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study comprised a cohort of 36 patients with triple negative breast cancer (TNBC) to investigate co-activation of HH and canonical Wnt pathway in association to patient outcome. All patients had varying degrees of cytoplasmic sonic HH and glioma-associated oncogene homolog (Gli)-1 staining, which positively correlated with tumor stage...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29140274/an-efficient-approach-for-lipase-catalyzed-synthesis-of-retinyl-laurate-nutraceutical-by-combining-ultrasound-assistance-and-artificial-neural-network-optimization
#7
Shang-Ming Huang, Hsin-Ju Li, Yung-Chuan Liu, Chia-Hung Kuo, Chwen-Jen Shieh
Although retinol is an important nutrient, retinol is highly sensitive to oxidation. At present, some ester forms of retinol are generally used in nutritional supplements because of its stability and bioavailability. However, such esters are commonly synthesized by chemical procedures which are harmful to the environment. Thus, this study utilized a green method using lipase as a catalyst with sonication assistance to produce a retinol derivative named retinyl laurate. Moreover, the process was optimized by an artificial neural network (ANN)...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29139542/temporal-and-spatial-expression-patterns-of-hedgehog-receptors-in-the-developing-inner-and-middle-ear
#8
Jeong-Oh Shin, Harinarayana Ankamreddy, Naga Mahesh Jakka, Seokwon Lee, Un-Kyung Kim, Jinwoong Bok
The mammalian inner ear is a complex organ responsible for balance and hearing. Sonic hedgehog (Shh), a member of the Hedgehog (Hh) family of secreted proteins, has been shown to play important roles in several aspects of inner ear development, including dorsoventral axial specification, cochlear elongation, tonotopic patterning, and hair cell differentiation. Hh proteins initiate a downstream signaling cascade by binding to the Patched 1 (Ptch1) receptor. Recent studies have revealed that other types of co-receptors can also mediate Hh signaling, including growth arrest-specific 1 (Gas1), cell-adhesion molecules-related/down-regulated by oncogenes (Cdon), and biregional Cdon binding protein (Boc)...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29138404/neonicotinoid-pesticide-limits-improvement-in-buzz-pollination-by-bumblebees
#9
P R Whitehorn, C Wallace, M Vallejo-Marin
Neonicotinoid pesticides have been linked to global declines of beneficial insects such as bumblebees. Exposure to trace levels of these chemicals causes sub-lethal effects, such as reduced learning and foraging efficiency. Complex behaviours may be particularly vulnerable to the neurotoxic effects of neonicotinoids. Such behaviours may include buzz pollination (sonication), in which pollinators, usually bees, use innate and learned behaviours to generate high-frequency vibrations to release pollen from flowers with specialised anther morphologies...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#10
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29137788/ultrasonic-assisted-manufacturing-of-new-hydrogel-nanocomposite-biosorbent-containing-calcium-carbonate-nanoparticles-and-tragacanth-gum-for-removal-of-heavy-metal
#11
Shadpour Mallakpour, Amir Abdolmaleki, Farbod Tabesh
This article reports the first incorporation of calcium carbonate nanoparticles (CC NPs) into tragacanth gum (TG) to prepare a new hydrogel nanocomposite (HNC) system using a green, safe, and eco-friendly method, ultrasound irradiation as an efficient biosorbent of heavy metal ions from wastewater. Morphological studies revealed that the surface of obtained HNCs is rough, homogeneous, and porous-like due to the embedding of CC NPs as well as sonication in comparison to the neat TG which has a smooth surface...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137787/ultrasound-impact-on-whey-protein-concentrate-pectin-complexes-and-in-the-o-w-emulsions-with-low-oil-soybean-content-stabilization
#12
Kivia M Albano, Vânia R Nicoletti
Consumers' preference for products with reduced levels of fat increased in the last years. Proteins and polysaccharides have an important role due to their functional and interaction properties because, when combined in ratios and pH of higher potential for electrostatic interactions they may act as emulsifiers or stabilizers. This study evaluated the ultrasound impact on the electrostatic interaction between pectin (PEC) and whey protein concentrate (WPC) at different WPC:PEC ratios (1:1 to 5:1), and its effect on the emulsification and stability of emulsions formulated with WPC:PEC blends (1:1, 4:1) at low soybean oil contents (5 to 15%)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137783/probing-the-radical-chemistry-and-the-reaction-zone-during-the-sono-degradation-of-endocrine-disruptor-2-phenoxyethanol-in-water
#13
Zineb Boutamine, Oualid Hamdaoui, Slimane Merouani
Sonochemical degradation at 600 kHz of 2-phenoxyethanol (PhE), an endocrine disrupting compound, was performed in the presence of several organic additives, namely: 2-propanol, Triton X-100 and sucrose, of different volatilities to obtain detailed information on the reaction zone and the oxidation pathway of this priority emerging water contaminate. It was found that sonication at 600 kHz and 120 W completely remove PhE (10 mg L(-1)) from aerated solutions within 100 min of irradiation. Very little removal of PhE (∼7%) and low accumulation of H2O2 took place in the presence of adequate amount of 2-propanol, indicating that reaction with OH radical outside the bubble is the major degradation pathway of PhE...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137780/sonication-affects-the-quantity-and-the-morphology-of-zno-nanostructures-synthesized-on-the-mild-steel-and-changes-the-corrosion-protection-of-the-surface
#14
Zahra Sharifalhoseini, Mohammad H Entezari, Mohsen Shahidi
The several types of sonication methods were applied to access the different morphologies of ZnO nanostructures on the surface of mild steel. To achieve this goal, a sonictor equipped with the probe extender was used as a high intensity ultrasonic apparatus for direct sonication. Furthermore, an ultrasonic bath (low intensity) and a cup-horn system (high intensity) were applied for indirect sonication. To find the effect of the acoustic waves on the ZnO morphology, the micrographs of obtained surfaces were compared to the sample prepared by the conventional method using scanning electron microscopy (SEM)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137779/physicochemical-properties-of-germinated-dehulled-rice-flour-and-energy-requirement-in-germination-as-affected-by-ultrasound-treatment
#15
Junzhou Ding, Gary G Hou, Mengyi Dong, Shanbai Xiong, Siming Zhao, Hao Feng
Limited data are published regarding changes in the physicochemical properties of rice flours from germinated de-hulled rice treated by ultrasound. This work was undertaken to evaluate the effect of ultrasound treatment (25 kHz, 16 W/L, 5 min) on starch hydrolysis and functional properties of rice flours produced from ultrasound-treated red rice and brown rice germinated for up to 36 h. Environmental Scanning Electron Microscopy (ESEM) microimages showed that the ultrasound treatment altered the surface microstructure of rice, which helped to improve moisture transfer during steam-cooking...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137777/zinc-oxide-nanoleaves-a-scalable-disperser-assisted-sonochemical-approach-for-synthesis-and-an-antibacterial-application
#16
Anadi Gupta, Rohit Srivastava
Current study reports a new and highly scalable method for the synthesis of novel structure Zinc oxide nanoleaves (ZnO-NLs) using disperser-assisted sonochemical approach. The synthesis was carried out in different batches from 50mL to 1L to ensure the scalability of the method which produced almost similar results. The use of high speed (9000rpm) mechanical dispersion while bath sonication (200W, 33kHz) yield 4.4g of ZnO-NLs powder in 1L batch reaction within 2h (>96% yield). The ZnO-NLs shows an excellent thermal stability even at a higher temperature (900°C) and high surface area...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137770/numerical-investigation-of-the-inertial-cavitation-threshold-under-multi-frequency-ultrasound
#17
Dingjie Suo, Bala Govind, Shengqi Zhang, Yun Jing
Through the introduction of multi-frequency sonication in High Intensity Focused Ultrasound (HIFU), enhancement of efficiency has been noted in several applications including thrombolysis, tissue ablation, sonochemistry, and sonoluminescence. One key experimental observation is that multi-frequency ultrasound can help lower the inertial cavitation threshold, thereby improving the power efficiency. However, this has not been well corroborated by the theory. In this paper, a numerical investigation on the inertial cavitation threshold of microbubbles (MBs) under multi-frequency ultrasound irradiation is conducted...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137769/ultrasound-ionic-liquid-enhanced-enzymatic-and-acid-hydrolysis-of-biomass-cellulose
#18
Xiaojie Yu, Xinjie Bao, Cunshan Zhou, Lei Zhang, Abu El-Gasim A Yagoub, Hongpeng Yang, Haile Ma
The purpose of this paper was to investigate the effect of ultrasound-ionic liquid (IL) pretreatment on the enzymatic and acid hydrolysis of the sugarcane bagasse and wheat straw. The lignocellulosic biomass was dissociated in ILs ([Bmim]Cl and [Bmim]AOC) aided by ultrasound waves. Sonication was performed at different frequencies (20, 28, 35, 40, and 50kHz), a power of 100W, a time of 30min and a temperature of 80°C. The changes in the structure and crystallinity of the cellulose were studied by Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137768/low-frequency-ultrasonic-assisted-hydrolysis-of-starch-in-the-presence-of-%C3%AE-amylase
#19
Anne Gaquere-Parker, Tamera Taylor, Raihannah Hutson, Ashley Rizzo, Aubrey Folds, Shastina Crittenden, Neelam Zahoor, Bilal Hussein, Aaron Arruda
Hydrolysis of starch is an important process in the food industry and in the production of bioethanol or smaller carbohydrate molecules that can be used as starting blocks for chemical synthesis. Such hydrolysis can be enhanced by lowering the pH, heating the reaction mixture or catalyzing the reaction with enzymes. This study reports the effect of sonication on the reaction rate of starch hydrolysis at different temperatures, in the presence or absence of alpha-amylase. Starch Azure, a commercially available potato starch covalently linked with Remazol Brilliant Blue, has been chosen since its hydrolysis releases a blue dye, which concentration can be monitored by UV Vis spectroscopy...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137766/mild-synthesis-of-a-zn-ii-metal-organic-polymer-and-its-hybrid-with-activated-carbon-application-as-antibacterial-agent-and-in-water-treatment-by-using-sonochemistry-optimization-kinetic-and-isotherm-study
#20
Tahere Taghipour, Gholamreza Karimipour, Mehrorang Ghaedi, Arash Asfaram
In this work, a room temperature and short method (30min) for synthesis of nanosized rod-like metal organic polymer (MOP) has been described. Reaction of 1,4-phenylenedioxy diacetic acid with zinc salt leads to the formation of [Zn(C10H8O6)(H2O)4]n and subsequently was loaded on activated carbon following sonication and structurally characterized by FTIR, SEM, EDX and XRD analysis. The combination of this new composite with sonication was applied for rapid and efficient adsorption of Bromocresol Purple (BCP)...
March 2018: Ultrasonics Sonochemistry
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