keyword
https://read.qxmd.com/read/38373634/clinical-features-of-pasteurellosis-without-an-animal-bite-or-scratch-in-comparison-with-bite-scratch-pasteurellosis
#21
JOURNAL ARTICLE
Tsubasa Asaeda, Takashi Ueda, Yasuhiro Nozaki, Yasushi Murakami, Mika Morosawa, Hiroko Inaba, Hitoshi Ogashiwa, Miki Doi, Kazuhiko Nakajima, Manabu Shirakawa, Akifumi Nakamura, Naoto Ikeda, Yuya Sugiyama, Yoshihiro Wada, Takahiro Ito, Yoshio Takesue
Pasteurellosis is a common zoonotic infection that occurs after an animal bite or scratch (B/S). We compared the clinical features of six patients with non-B/S pasteurellosis with those of 14 patients with B/S infections. Pasteurella multocida was identified with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all six non-B/S infections, whereas 13 of the 14 B/S infections were identified with diagnostic kits. The non-B/S infections were pneumonia (n = 3), skin and soft tissue infections (n = 2), and bacteremia (n = 1)...
February 17, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38364278/a-wearable-gait-analysis-device-for-idiopathic-normal-pressure-hydrocephalus-inph-monitoring
#22
JOURNAL ARTICLE
Erdem Atbas, Patrick Gaydecki, Michael Callaghan
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive neurologic disorder (fluid build-up in the brain) that affects 0.2-5% of the UK population aged over 65. Mobility problems, dementia and urinary incontinence are symptoms of iNPH but often these are not properly evaluated, and patients receive the wrong diagnosis. Here, we describe the development and testing of a wearable device that records and analyses a patient's gait. The movement patterns, expressed as quantitative data, allow clinicians to improve the non-invasive diagnosis of iNPH as well as monitor the management of patients undergoing treatment...
February 16, 2024: Biomedical Physics & Engineering Express
https://read.qxmd.com/read/38360560/neurocognitive-change-over-the-course-of-a-multiday-external-lumbar-drain-trial-in-patients-with-suspected-normal-pressure-hydrocephalus
#23
JOURNAL ARTICLE
Michael Brook, James Reilly, Alexander Korutz, Matthew C Tate, John-Christopher A Finley, Emma Pollner, Ketan Yerneni, Caterina Mosti, Constantine Karras, Siting Joy Trybula, John Stratton, Zoran Martinovich
Objective: To characterize neurocognitive response to cerebrospinal fluid (CSF) diversion during a multiday external lumbar drainage (ELD) trial in patients with suspected normal pressure hydrocephalus (NPH). Methods: Inpatients ( N  = 70) undergoing an ELD trial as part of NPH evaluation participated. Cognition and balance were assessed using standardized measures before and after a three-day ELD trial. Cognitive change pre- to post-ELD trial was assessed in relation to change in balance, baseline neuroimaging findings, NPH symptoms, demographics, and other disease-relevant clinical parameters...
February 15, 2024: Clinical Neuropsychologist
https://read.qxmd.com/read/38355601/cerebrospinal-fluid-shunt-surgery-reduces-the-risk-of-developing-dementia-and-alzheimer-s-disease-in-patients-with-idiopathic-normal-pressure-hydrocephalus-a-nationwide-population-based-propensity-weighted-cohort-study
#24
JOURNAL ARTICLE
Pao-Hui Tseng, Wan-Ting Huang, Jen-Hung Wang, Bor-Ren Huang, Hsin-Yi Huang, Sheng-Tzung Tsai
BACKGROUND: Patients with idiopathic normal-pressure hydrocephalus (iNPH) are predisposed to developing dementing disorders. Cerebrospinal fluid (CSF) shunt implantation is a treatment used to improve the motor and cognitive disabilities of these patients; however, its effect on the risk of developing dementing disorders remains unclear. We conducted a population-based propensity-weighted cohort study to investigate whether CSF shunt surgery may reduce the risk of subsequently developing dementia, Alzheimer's disease (AD), and vascular dementia in iNPH patients...
February 14, 2024: Fluids and Barriers of the CNS
https://read.qxmd.com/read/38352023/the-role-of-cytokines-and-chemokines-in-the-maintenance-of-chronic-pain-a-pilot-study
#25
JOURNAL ARTICLE
Josephine Lassen, Frank Leypoldt, Philipp Hüllemann, Maren Janssen, Ralf Baron, Janne Gierthmühlen
INTRODUCTION: The immune system is believed to be important in the initiation and maintenance of chronic pain. OBJECTIVES: The aim was to investigate whether patients with chronic painful polyneuropathy (PP) differ in cytokine profiles of serum and/or cerebrospinal fluid (CSF) compared with pain-free controls. METHODS: Thirty-nine patients (16 women and 23 men, mean age, 69.2 ± 12.7 years, range 41-92 years) with PP (mean duration 43 ± 48...
April 2024: Pain Reports
https://read.qxmd.com/read/38351565/-movement-disorders-and-rehabilitation-in-idiopathic-normal-pressure-hydrocephalus
#26
JOURNAL ARTICLE
Yasutaka Nikaido
Movement disorders, particularly gait and balance disturbances can lead to falls and reduced daily activities in patients with idiopathic normal pressure hydrocephalus (iNPH). In this study, we investigate movement disorders from both the pathophysiological and kinematic perspectives in patients with iNPH. Additionally, we discuss essential factors that should be evaluated before and after cerebrospinal fluid tap tests and shunt surgeries and considerations for assessment of fall risk in patients with iNPH...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351564/-preoperative-predictors-of-outcomes-of-cerebrospinal-fluid-shunt-surgery-in-patients-with-idiopathic-normal-pressure-hydrocephalus
#27
JOURNAL ARTICLE
Shigenori Kanno, Kyoko Suzuki
The disproportionately enlarged subarachnoid space hydrocephalus (DESH) findings on cranial images are useful to predict cerebrospinal fluid (CSF) shunt responsiveness to some extent in patients with idiopathic normal-pressure hydrocephalus (iNPH). However, recent studies show that patients with iNPH often have concomitant Alzheimer's or Lewy body disease regardless of DESH findings, which may be associated with poor outcomes of CSF shunt surgery. Moreover, long-term outcomes after CSF shunt surgery in patients with iNPH, which is one of the most important issues to be addressed for effective treatment of iNPH, remain unknown...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351563/-surgical-management-of-idiopathic-normal-pressure-hydrocephalus
#28
JOURNAL ARTICLE
Daisuke Kita
Cerebrospinal fluid shunting, including ventriculo-abdominal/atrial and lumbar-abdominal shunts, is the only treatment available for idiopathic normal pressure hydrocephalus (iNPH). Hybrid valves that combine a programmable pressure valve and an antisiphon device are being widely used for treatment of iNPH, which has significantly minimized surgical complications, such as shunt revision and subdural hematomas associated with overdrainage. Development of novel technologies that can maintain a more physiological intracranial environment after shunting presents a challenge for future research...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351562/-biomarkers-of-idiopathic-normal-pressure-hydrocephalus
#29
JOURNAL ARTICLE
Madoka Nakajima
Although the pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remain largely unknown, it is well acknowledged that iNPH causes ventricular enlargement due to decreased cerebrospinal fluid (CSF) absorption. Pathophysiologically, it is supposed that the excretion of waste proteins is impaired along with CSF. Hence, they tend to aggregate, and in many neurodegenerative diseases, abnormal aggregation and accumulation of such proteins are deeply involved in the pathogenesis of disease. Biomarkers (BMs) contribute to diagnosis by identifying comorbid neurodegenerative diseases that may affect the prognosis of treatment, as well as exploring the pathogenetic mechanisms of iNPH...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351561/-recent-developments-in-diagnostic-imaging-for-idiopathic-normal-pressure-hydrocephalus
#30
JOURNAL ARTICLE
Ryuichi Takahashi, Kazunari Ishii
Idiopathic normal pressure hydrocephalus (iNPH), a syndrome characterized by cognitive impairment, gait abnormalities, and urinary incontinence attributable to cerebrospinal fluid circulatory insufficiency, is associated with an obscure etiology. Several methodologies and imaging analysis techniques, including visualization of cerebral hemodynamics and diffusion tensor imaging have emerged in recent years to determine functional alterations in cases of iNPH. These advancements have led to more comprehensive understanding of the pathophysiological mechanisms underlying iNPH...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351560/-neuropathology-of-idiopathic-normal-pressure-hydrocephalus-a-study-of-three-autopsy-cases-and-a-literature-review
#31
JOURNAL ARTICLE
Hajime Miyata, Eisaku Ohama
We present neuropathological findings in three autopsy brains from patients diagnosed clinically with idiopathic normal pressure hydrocephalus (iNPH) in Japan; still, specific findings of iNPH remain unclear. Comorbid atherosclerosis and hypertensive microvascular diseases, including arterio- and arteriolosclerosis and ischemic changes in the brain parenchyma, are frequently (65%) observed in autopsy brain tissue from patients with iNPH, which has drawn attention to the clinicopathological similarities and differences between iNPH and Binswanger's disease...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351559/-challenges-to-distinguish-idiopathic-normal-pressure-hydrocephalus-from-progressive-supranuclear-palsy
#32
JOURNAL ARTICLE
Masahiro Ohara
Idiopathic normal pressure hydrocephalus (iNPH) is a clinical condition characterized by symptoms of gait disturbance, cognitive dysfunction, and urinary disturbance. In contrast, progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease characterized by supranuclear gaze palsy, akinetic rigidity, gait disturbance, and dementia. PSP manifests various clinical phenotypes that mimic other diseases and occasionally present iNPH-like presentations. Our previous publication showed that PSP develops iNPH-like magnetic resonance imaging (MRI) features more frequently than other neurodegenerative diseases...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351558/-epidemiology-natural-history-and-genetic-factors-of-idiopathic-normal-pressure-hydrocephalus
#33
JOURNAL ARTICLE
Chifumi Iseki
According to a cohort study in a Japanese rural area, the prevalence of idiopathic normal pressure hydrocephalus (iNPH) in the 80s was 7.7% among the older inhabitants, despite only a small percentage of the population seeking consultation. The 16-year observation of the cohort revealed that people were in the state of asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging or asymptomatic ventricular enlargement several years before presenting symptoms and intracranial changes of iNPH...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351557/-glymphatic-system-and-idiopathic-normal-pressure-hydrocephalus
#34
JOURNAL ARTICLE
Masafumi Ihara
The inflow channel of the glymphatic pathway is the basilar membrane formed by the pia matter and glial border membrane in the outermost layer of the artery. Cerebrospinal fluid from the subarachnoid space enters the brain parenchyma through this pathway, and its water component is pumped into the brain parenchyma through aquaporin 4. One of the driving forces is vascular pulsation, and if this pathway becomes inoperative, cerebrospinal fluid loses its normal dynamics and contributes to idiopathic normal pressure hydrocephalus...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351556/-overview-of-the-guidelines-for-managing-idiopathic-normal-pressure-hydrocephalus
#35
JOURNAL ARTICLE
Hiroaki Kazui, Ryo Kawai
Japanese guidelines for idiopathic normal pressure hydrocephalus (iNPH) (iNPHGL) are the first and only guidelines in the world that were revised following subsequent developments in iNPH research. We first discuss the virtuous cycle in which the development and revision of the iNPHGL and how the implementation of two consecutive multicenter prospective studies conducted in Japan, SINPHONIs, have worked together to advance iNPH practices. Subsequently, we explained the most characteristic features of the iNPHGL, such as "Positioning of iNPH," "Diagnostic Criteria," and "Algorithms for Diagnosis and Treatment...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38351555/-symptomatology-of-idiopathic-normal-pressure-hydrocephalus
#36
JOURNAL ARTICLE
Etsuro Mori
Idiopathic normal pressure hydrocephalus causes a triad of gait disturbance, dementia, and urinary incontinence in the elderly. All these symptoms may manifest as age-related functional decline or from neurological and non-neurological diseases common in the elderly. In idiopathic normal pressure hydrocephalus, characterized by ataxic-ataxic gait, subcortical dementia, and urge urinary incontinence, it is clinically important to consider these characteristic features. This overview describes the symptomatology of idiopathic normal pressure hydrocephalus...
February 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38315313/in-vivo-assessment-of-the-ocular-biomechanical-properties-in-patients-with-idiopathic-normal-pressure-hydrocephalus
#37
JOURNAL ARTICLE
Nicola Valsecchi, Matilde Roda, Simone Febbraro, Eleonora Trolli, Giorgio Palandri, Giulia Giannini, David Milletti, Costantino Schiavi, Luigi Fontana
PURPOSE: Idiopathic normal pressure hydrocephalus (iNPH) is associated with an increased prevalence of open-angle glaucoma, attributed to variations of the pressure gradient between intraocular and intracranial compartments at the level of the lamina cribrosa (LC). As ocular biomechanics influence the behavior of the LC, and a lower corneal hysteresis (CH) has been associated to a higher risk of glaucomatous optic nerve damage, in this study we compared ocular biomechanics of iNPH patients with healthy subjects...
February 2, 2024: International Ophthalmology
https://read.qxmd.com/read/38299130/persistent-intracranial-hypertension-and-severe-hypoglycorrhachia-in-an-adult-with-giant-congenital-melanocytic-naevi
#38
Debbie Kong, Sanihah Abdul Halim
A 29-year-old female, with giant congenital melanocytic naevi (GCMN) presented with a-year history of symptoms and signs of intracranial hypertension. Investigations revealed raised cerebrospinal fluid (CSF) pressure and severe hypoglycorrhachia (low CSF glucose) without pleocytosis. Initial contrast-enhanced brain MRI was normal, but a repeat MRI after a year showed meningeal enhancement with mild communicating hydrocephalus. The raised intracranial pressure was treated with a lumbar-peritoneal shunt. Intraoperative CSF cytology revealed an abundance of squamous epithelia and degenerative cells, but no malignant cells...
December 2023: Curēus
https://read.qxmd.com/read/38296639/meningitis-in-the-guise-of-dementia-lyme-induced-normal-pressure-hydrocephalus
#39
JOURNAL ARTICLE
Ryan Liu, Matheus Polly, Robert P Lennon, Alexis Reedy-Cooper
While the cause of altered mentation in the elderly may be multifactorial, infectious etiologies may be missed. This case report aims to detail an account of a patient with dementia, found to have Lyme meningitis in the setting of a normal pressure hydrocephalus (NPH). The patient smelled of urine and presented with ambulatory dysfunction, fitting the "wet, wacky, and wobbly" triad of NPH while also having subjective chills and leukocytosis. Non-contrast brain CT scan showed dilated ventricles. Cerebrospinal fluid (CSF) studies suggested aseptic meningitis...
December 2023: Clinical Medicine & Research
https://read.qxmd.com/read/38295900/usefulness-of-third-ventricle-volumetry-in-patients-with-normal-pressure-hydrocephalus
#40
JOURNAL ARTICLE
Herbert Daniel Jiméne Zapata, Adrián Fernández García, Carla Timisoara Amilburu Sáenz, Carlos Alberto Rodríguez Arias
OBJECTIVE: To use third ventricle morphometric variables as a tool for the selection of patients with idiopathic normal pressure hydrocephalus (iNPH) who are candidates for ventriculoperitoneal shunts (VPS). MATERIAL AND METHODS: Retrospective study enrolling patients with iNPH. Katzman infusion test was performed and a Rout>12 mmHg/ml/min was considered a positive result. The transverse diameter and the volume of the third ventricle were measured in the preoperative MRI...
January 29, 2024: Neurocirugía (English Edition)
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