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normal-pressure hydrocephalus

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https://www.readbyqxmd.com/read/27917383/hakim-adams-syndrome-an-unusual-cause-of-reversible-postoperative-coma
#1
Mohamed Saleh, Marine Bouex
We report the case of a 72-year-old patient presenting in our ICU with persistent postoperative coma in a context of recent unexplored neurological dysfunction. Detailed medical history taking from the patient's family revealed he recently suffered from gait instability, urinary incontinence, and slight cognitive impairment. These constituted the clinical triad of normal pressure hydrocephalus syndrome. The presence of normal cerebrospinal fluid (CSF) pressure and distinctive radiological findings confirmed the diagnosis of normal pressure hydrocephalus or Hakims-Adams syndrome...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27916758/-hydrocephalus-mimicking-idiopathic-normal-pressure-hydrocephalus-as-the-first-manifestation-of-neurosarcoidosis
#2
Atsuhiko Sugiyama, Makoto Kobayashi, Kumiko Agatsuma, Takeshi Bo, Toshiaki Shiojiri, Hidetoshi Mochida, Yoshio Suzuki, Takashi Matsunaga, Satoshi Kuwabara
A 61-year-old woman presented with a 10-month history of gait disturbance and a 7-month history of urinary incontinence. The Hasegawa dementia scale-revised score indicated cognitive impairment. Brain magnetic resonance imaging (MRI) indicated hydrocephalus with disproportionately enlarged subarachnoid space. This is usually considered a characteristic finding in idiopathic normal pressure hydrocephalus (iNPH). Ventriculo-peritoneal shunting improved the patient's symptoms. Neurosarcoidosis was suspected as a cause of the hydrocephalus because of the abnormalities in the cerebrospinal fluid and the abnormal enhancement of the cauda equina, the leptomeninges of the brainstem, and the spinal cord, as seen on MRI with gadolinium enhancement...
December 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27913261/typical-symptoms-of-normal-pressure-hydrocephalus-caused-by-choroid-plexus-papilloma-in-the-cerebellopontine-angle-a-case-report
#3
Hiroshi Ito, Yukiko Nakahara, Masatou Kawashima, Jun Masuoka, Tatsuya Abe, Toshio Matsushima
BACKGROUND: Choroid plexus papillomas (CPPs) are rare benign intracranial tumors. Here, we report a rare case of CPP presenting with typical symptoms of normal-pressure hydrocephalus not with obstructive hydrocephalus. CASE DESCRIPTION: A 45-year-old female presented with a 6-year history of headache and typical symptoms of normal-pressure hydrocephalus (NPH) such as gait disturbance, urinary incontinence, and cognitive dysfunction in addition to the more common symptoms of choroid plexus papillomas (CPP), such as lower cranial nerve dysfunctions and ataxia...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27911315/decreased-expression-of-hsa-mir-4274-in%C3%A2-cerebrospinal-fluid-of-normal-pressure-hydrocephalus-mimics-with-parkinsonian-syndromes
#4
Ivana Jurjević, Masakazu Miyajima, Ikuko Ogino, Chihiro Akiba, Madoka Nakajima, Akihide Kondo, Mika Kikkawa, Mitsuyasu Kanai, Nobutaka Hattori, Hajime Arai
BACKGROUND: Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences the long-term outcome of cerebrospinal fluid (CSF) shunting. OBJECTIVE: The aim of this study was to find potential CSF microRNA (miRNA) biomarkers for NPH mimics with parkinsonian syndromes that can reliably distinguish them from iNPH patients. METHODS: Two cohorts of 81 patients (cohort 1, n = 55; cohort 2, n = 26) with possible iNPH who were treated in two centers between January 2011 and May 2014 were studied...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27878614/associations-of-intracranial-pressure-with-brain-biopsy-radiological-findings-and-shunt-surgery-outcome-in-patients-with-suspected-idiopathic-normal-pressure-hydrocephalus
#5
Maria Kojoukhova, Krista-Irina Vanha, Matti Timonen, Anne M Koivisto, Ossi Nerg, Jaana Rummukainen, Tuomas Rauramaa, Ritva Vanninen, Juha E Jääskeläinen, Anna Sutela, Ville Leinonen
BACKGROUND: It remains unclear how intracranial pressure (ICP) measures are associated with brain biopsies and radiological markers. Here, we aim to investigate associations between ICP and radiological findings, brain biopsies, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus (iNPH). METHOD: In this study, we retrospectively analyzed data from 73 patients admitted with suspected iNPH to Kuopio University Hospital. Of these patients, 71% underwent shunt surgery...
November 23, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27876063/early-and-delayed-assessments-of-quantitative-gait-measures-to-improve-the-tap-test-as-a-predictor-of-shunt-effectiveness-in-idiopathic-normal-pressure-hydrocephalus
#6
Masatsune Ishikawa, Shigeki Yamada, Kazuo Yamamoto
BACKGROUND: To improve the diagnostic performance of the cerebrospinal fluid (CSF) tap test (TT), early and delayed assessments of gait were performed after the removal of 30 ml of CSF in patients with probable idiopathic normal pressure hydrocephalus. Assessments of gait included the 3-m timed up and go test (TUG), and the 10-m walk in time (10Ti) and in step (10St) tests. METHODS: Quantitative data for the TUG, the 10Ti, and the 10St were obtained before CSF removal and on days 1 and 4 after removal of 30 ml CSF...
November 22, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27871440/investigation-and-clinical-applications-of-muscle-strength-change-in-cerebrospinal-fluid-tap-test-in-cases-of-idiopathic-normal-pressure-hydrocephalus-a-retrospective-study
#7
Tsuyoshi Matsuoka, Jun-Ichi Iida, Makoto Kawahara, Yoshitomo Uchiyama
The cerebrospinal fluid tap test (CSFTT) is widely used to diagnose idiopathic normal pressure hydrocephalus (iNPH) and predict the therapeutic effectiveness of shunting. However, the ability to walk cannot be quantified for patients who are unable to walk. Therefore, we examined whether the iNPH diagnostic aid is possible using dynamometry, even for patients who are unable to walk. In this study, 45 patients underwent grip strength assessment, quadriceps strength assessment, 10-m walk test, and 3-m Timed Up and Go test before and after CSFTT...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27869301/cerebral-amyloid-deposition-is-associated-with-gait-parameters-in-the-mayo-clinic-study-of-aging
#8
Alexandra M V Wennberg, Rodolfo Savica, Clinton E Hagen, Rosebud O Roberts, David S Knopman, John H Hollman, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
OBJECTIVES: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. DESIGN: Cross-sectional. SETTING: Population-based cohort study in Olmsted County, MN. PARTICIPANTS: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27861535/a-segmental-copy-number-loss-of-the-sfmbt1-gene-is-a-genetic-risk-for-shunt-responsive-idiopathic-normal-pressure-hydrocephalus-inph-a-case-control-study
#9
Hidenori Sato, Yoshimi Takahashi, Luna Kimihira, Chifumi Iseki, Hajime Kato, Yuya Suzuki, Ryosuke Igari, Hiroyasu Sato, Shingo Koyama, Shigeki Arawaka, Toru Kawanami, Masakazu Miyajima, Naoyuki Samejima, Shinya Sato, Masahiro Kameda, Shinya Yamada, Daisuke Kita, Mitsunobu Kaijima, Isao Date, Yukihiko Sonoda, Takamasa Kayama, Nobumasa Kuwana, Hajime Arai, Takeo Kato
Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be a genetic risk for shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% of shunt-responsive definite iNPH patients (n = 50) had such a genetic change, as compared with 4.2% of the healthy elderly (n = 191) (OR = 7.94, 95%CI: 2.82-23.79, p = 1.8 x 10-5) and 6.3% of patients with Parkinson's disease (n = 32) (OR = 5...
2016: PloS One
https://www.readbyqxmd.com/read/27858384/efficacy-of-lumboperitoneal-shunting-in-patients-with-normal-pressure-hydrocephalus
#10
Mehmet Akif Bayar, Ayhan Tekiner, Haydar Celik, Ali Yilmaz, Guner Menekse, Timur Yildirim, Fatih Alagoz, Yahya Guvenc, Yavuz Erdem
AIM: To evaluate the effectiveness of lumboperitoneal shunt procedures in the treatment of normal pressure hydrocephalus Material and Methods: A medical record review was conducted to obtain demographic, clinical, laboratory data, as well as pre-, intra, -post-operative details of 65 patients who underwent lumboperitoneal shunt surgery between January 1, 2001 and January 1, 2014 in the Neurosurgery Clinics of Ankara Training and Research Hospital and Ankara Numune Hospital. RESULTS: At about 3 months after LP shunt surgery, the complaint of headache resolved in almost all patients; at the end of the first year, while statistically significant improvements were noted in the Modified Rankin Scores and Mini Mental Test Scores, gait disturbance, urinary incontinence and cognitive functions improved by 86%, 72% and 65% of the patients, respectively...
October 14, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27845954/sulfonylurea-receptor-1-a-novel-biomarker-for-cerebral-edema-in-severe-traumatic-brain-injury
#11
Ruchira M Jha, Ava M Puccio, Sherry Hsiang-Yi Chou, Chung-Chou H Chang, Jessica S Wallisch, Bradley J Molyneaux, Benjamin E Zusman, Lori A Shutter, Samuel M Poloyac, Keri L Janesko-Feldman, David O Okonkwo, Patrick M Kochanek
OBJECTIVES: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies. Sulfonylurea receptor-1-transient receptor potential cation channel M4 is upregulated only after brain injury, causing edema in animal studies. We hypothesized that sulfonylurea receptor-1 is measurable in human cerebrospinal fluid after severe traumatic brain injury and is an informative biomarker of edema and outcome...
November 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27816462/-lower-urinary-tract-dysfunction-in-normal-pressure-hydrocephalus-review-of-the-literature
#12
E Bey, B Nicot, O Casez, L Le Normand
INTRODUCTION: Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. The aim of this review article was to discuss diagnostic and therapeutic options for these patients. SOURCES: A literature review of MedLine publications on urinary incontinence in normal pressure hydrocephalus was conducted. The following keywords were used: "hydrocephalus, normal pressure" and "bladder dysfunction" or "urinary incontinence" or "overactive bladder" or "urinary bladder, neurogenic"...
December 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27802227/effects-of-alzheimer-s-disease-associated-risk-loci-on-amyloid-%C3%AE-accumulation-in-the-brain-of-idiopathic-normal-pressure-hydrocephalus-patients
#13
Tiina Laiterä, Jussi Paananen, Seppo Helisalmi, Timo Sarajärvi, Joel Huovinen, Marjo Laitinen, Tuomas Rauramaa, Irina Alafuzoff, Anne M Remes, Hilkka Soininen, Annakaisa Haapasalo, Juha E Jääskeläinen, Ville Leinonen, Mikko Hiltunen
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a dementing condition featuring characteristic symptoms, ventriculomegaly, and normal or slightly elevated cerebrospinal fluid pressure. In Alzheimer's disease (AD) patients, diffuse aggregates of amyloid-β (Aβ) and neurofibrillary hyperphosphorylated tau are detected in the neocortex of the brain, while similar accumulation of Aβ is also detected in iNPH. Recent genome-wide association studies have identified several novel risk loci for AD, potentially affecting Aβ-related cellular processes...
October 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27790243/the-effect-of-spinal-tap-test-on-different-sensory-modalities-of-postural-stability-in-idiopathic-normal-pressure-hydrocephalus
#14
Katrin Abram, Silvia Bohne, Peter Bublak, Panagiota Karvouniari, Carsten M Klingner, Otto W Witte, Orlando Guntinas-Lichius, Hubertus Axer
BACKGROUND/AIMS: Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. METHODS: Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic posturography (CDP), and neuropsychological assessment. Examinations were done before and after spinal tap test...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27787666/neurite-orientation-dispersion-and-density-imaging-for-evaluation-of-corticospinal-tract-in-idiopathic-normal-pressure-hydrocephalus
#15
Ryusuke Irie, Kohei Tsuruta, Masaaki Hori, Michimasa Suzuki, Koji Kamagata, Atsushi Nakanishi, Kouhei Kamiya, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Shigeki Aoki
PURPOSE: To evaluate diffusional changes of the corticospinal tract (CST) in patients with idiopathic normal pressure hydrocephalus (iNPH) by neurite orientation dispersion and density imaging (NODDI). MATERIALS AND METHODS: Nineteen patients with iNPH and 12 healthy controls were included. Diffusion MRI data for NODDI were acquired with a 3-T system, using 32 motion-probing gradient directions with six b-values (from 0 to 2500 s/mm(2)). The orientation dispersion index (ODI), intra-cellular volume fraction (Vic), and isotropic volume fraction (Viso) of the CST were calculated by tract-specific analysis in patients and controls...
October 27, 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27783098/-degenerative-cerebellar-diseases-and-differential-diagnoses
#16
W Reith, S Roumia, P Dietrich
CLINICAL/METHODICAL ISSUE: Cerebellar syndromes result in distinct clinical symptoms, such as ataxia, dysarthria, dysmetria, intention tremor and eye movement disorders. STANDARD RADIOLOGICAL METHODS: In addition to the medical history and clinical examination, imaging is particularly important to differentiate other diseases, such as hydrocephalus and multi-infarct dementia from degenerative cerebellar diseases. Degenerative diseases with cerebellar involvement include Parkinson's disease, multiple system atrophy as well as other diseases including spinocerebellar ataxia...
October 25, 2016: Der Radiologe
https://www.readbyqxmd.com/read/27773546/evaluating-the-effect-of-hydrocephalus-cause-on-the-manner-of-changes-in-the-effective-parameters-and-clinical-symptoms-of-the-disease
#17
Seifollah Gholampour, Nasser Fatouraee, Amir Saeed Seddighi, Afsoun Seddighi
In the present study, the heads of 11 normal subjects and 21 patients affected by hydrocephalus due to three different causes were simulated using fluid-structure interaction (FSI). To validate the results, the calculated diagram of CSF velocity in aqueduct of Sylvius (AS) was compared with the similar velocity diagram measured using Cine PC-MRI for the same subject. After ensuring the agreement of results, other outputs such as CSF pressure were calculated non-invasively using FSI. The intracranial pressure and CSF pressure in AS and behind the optic nerve sheath were in patients 5-5...
October 20, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27761229/neurosyphilis-with-normal-pressure-hydrocephalus-and-dementia-paralytica-serial-clinical-laboratory-and-radiological-correlations-in-the-21st-century
#18
Kamille Abdool, Karan Seegobin, Kanterpersad Ramcharan, Adrian Alexander, Leandra Julien-Legen, Stanley Lawrence Giddings, Samuel Aboh, Fidel Rampersad
We report a case of a 46-year-old man presenting with a progressive cognitive decline, ataxic gait, urinary incontinence for 4 months and neuroimaging consistent with normal pressure hydrocephalus. The atypical presentation of a progressively worsening dysphasia and a right hemiparesis dismissed as a vascular event 1 month earlier associated with normal pressure hydrocephalus prompted further investigations confirming neurosyphilis also manifesting as dementia paralytica. Treatment using consensus guidelines led to resumption of activities of daily living...
September 30, 2016: Neurology International
https://www.readbyqxmd.com/read/27759679/a-novel-experimental-animal-model-of-adult-chronic-hydrocephalus
#19
Ignacio Jusué-Torres, Lee H Jeon, Eric W Sankey, Jennifer Lu, Tito Vivas-Buitrago, Joshua A Crawford, Mikhail V Pletnikov, Jiadi Xu, Ari Blitz, Daniel A Herzka, Barbara Crain, Alicia Hulbert, Hugo Guerrero-Cazares, Oscar Gonzalez-Perez, James P McAllister, Alfredo Quiñones-Hinojosa, Daniele Rigamonti
BACKGROUND: The pathogenesis of adult chronic hydrocephalus is not fully understood, and the temporal relationship between development of the radiological changes and neurological deterioration is unknown. OBJECTIVE: To clarify the progression of radiological-histological changes and subsequent clinical manifestations of adult chronic hydrocephalus. METHODS: Kaolin was injected bilaterally into the subarachnoid space overlying the cranial convexities in 20 adult rats...
November 2016: Neurosurgery
https://www.readbyqxmd.com/read/27743250/multimodal-analysis-to-predict-shunt-surgery-outcome-of-284-patients-with-suspected-idiopathic-normal-pressure-hydrocephalus
#20
Antti J Luikku, Anette Hall, Ossi Nerg, Anne M Koivisto, Mikko Hiltunen, Seppo Helisalmi, Sanna-Kaisa Herukka, Anna Sutela, Maria Kojoukhova, Jussi Mattila, Jyrki Lötjönen, Jaana Rummukainen, Irina Alafuzoff, Juha E Jääskeläinen, Anne M Remes, Hilkka Soininen, Ville Leinonen
OBJECTIVES: Optimal selection of idiopathic normal pressure hydrocephalus (iNPH) patients for shunt surgery is challenging. Disease State Index (DSI) is a statistical method that merges multimodal data to assist clinical decision-making. It has previously been shown to be useful in predicting progression in mild cognitive impairment and differentiating Alzheimer's disease (AD) and frontotemporal dementia. In this study, we use the DSI method to predict shunt surgery response for patients with iNPH...
October 14, 2016: Acta Neurochirurgica
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