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https://www.readbyqxmd.com/read/29774137/saudi-anti-human-cancer-plants-database-sacpd-a-collection-of-plants-with-anti-human-cancer-activities
#1
Ateeq Ahmed Al-Zahrani
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD)...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29773083/reprising-the-globalization-dimensions-of-international-health
#2
EDITORIAL
Ronald Labonté
Globalization is a fairly recent addition to the panoply of concepts describing the internationalization of health concerns. What distinguishes it from 'international health' or its newer morphing into 'global health' is a specific analytical concern with how globalization processes, past or present, but particularly since the start of our neoliberal era post-1980, is affecting health outcomes. Globalization processes influence health through multiple social pathways: from health systems and financing reforms to migration flows and internal displacement; via trade and investment treaties, labour market 'flexibilization', and the spread of unhealthy commodities; or through deploying human rights and environment protection treaties, and strengthening health diplomacy efforts, to create more equitable and sustainable global health outcomes...
May 18, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29771380/dbcan2-a-meta-server-for-automated-carbohydrate-active-enzyme-annotation
#3
Han Zhang, Tanner Yohe, Le Huang, Sarah Entwistle, Peizhi Wu, Zhenglu Yang, Peter K Busk, Ying Xu, Yanbin Yin
Complex carbohydrates of plants are the main food sources of animals and microbes, and serve as promising renewable feedstock for biofuel and biomaterial production. Carbohydrate active enzymes (CAZymes) are the most important enzymes for complex carbohydrate metabolism. With an increasing number of plant and plant-associated microbial genomes and metagenomes being sequenced, there is an urgent need of automatic tools for genomic data mining of CAZymes. We developed the dbCAN web server in 2012 to provide a public service for automated CAZyme annotation for newly sequenced genomes...
May 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29770085/a-guide-to-publishing-scientific-research-in-the-health-sciences
#4
P Huston, Bck Choi
Effective communication of scientific research is critical to advancing science and optimizing the impact of one's professional work. This article provides a guide on preparing scientific manuscripts for publication in the health sciences. It is geared to health professionals who are starting to report their findings in peer-reviewed journals or who would like to refresh their knowledge in this area. It identifies five key steps. First, adopt best practices in scientific publications, including collaborative writing and ethical reporting...
September 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29768340/the-patient-general-satisfaction-of-mandibular-single-implant-overdentures-and-conventional-complete-dentures-study-protocol-for-a-randomized-crossover-trial
#5
Manabu Kanazawa, Mariko Tanoue, Anna Miyayasu, Shin Takeshita, Daisuke Sato, Mari Asami, Thuy Vo Lam, Khaing Myat Thu, Ken Oda, Yuriko Komagamine, Shunsuke Minakuchi, Jocelyne Feine
BACKGROUND: Mandibular overdentures retained by a single implant placed in the midline of edentulous mandible have been reported to be more comfortable and function better than complete dentures. Although single-implant overdentures are still more costly than conventional complete dentures, there are a few studies which investigated whether mandibular single-implant overdentures are superior to complete dentures when patient general satisfaction is compared. The aim of this study is to assess patient general satisfaction with mandibular single-implant overdentures and complete dentures...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29754602/retracted-imprinted-zno-nanostructure-based-electrochemical-sensing-of-calcitonin-a-clinical-marker-for-medullary-thyroid-carcinoma
#6
Santanu Patra, Ekta Roy, Rashmi Madhuri, Prashant K Sharma
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor following concerns raised by various readers. The article reports different electron micrographs for different sample preparations, but some images are of different areas from the same sample. Figure 4E is a magnified section of Figure 4C, and the images are identical as demonstrated by overlapping the images and adjusting for magnification scale...
September 6, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29753347/economic-modeling-considerations-for-rare-diseases
#7
Isobel Pearson, Ben Rothwell, Andrew Olaye, Christopher Knight
OBJECTIVES: To identify challenges that affect the feasibility and rigor of economic models in rare diseases and strategies that manufacturers have employed in health technology assessment submissions to demonstrate the value of new orphan products that have limited study data. METHODS: Targeted reviews of PubMed, the National Institute for Health and Care Excellence's (NICE's) Highly Specialised Technologies (HST), and the Scottish Medicines Consortium's (SMC's) ultra-orphan submissions were performed...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29753134/the-use-of-human-tissue-in-safety-assessment
#8
Samuel J Jackson, Helen Prior, Anthony Holmes
INTRODUCTION: The safety-related failure of drugs during clinical phases of development is a significant contributor to drug attrition, wasting resources, preventing treatments from reaching patients. A lack of concordance between results from animal models and adverse events in the clinic has been identified as one potential cause of attrition. In vitro models using human tissue or cells have the potential to replace some animal models and improve predictivity to humans. METHODS: To gauge the current use of human tissue models in safety pharmacology and the barriers to greater uptake, an electronic survey of the international safety assessment community was carried out and a Safety Pharmacology Society European Regional Meeting was organised entitled 'The Use of Human Tissue in Safety Assessment'...
May 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29751764/challenges-to-decision-making-processes-in-the-national-hta-agency-in-brazil-operational-procedures-evidence-use-and-recommendations
#9
Tania Yuka Yuba, Hillegonda Maria Dutilh Novaes, Patrícia Coelho de Soárez
BACKGROUND: The quality of the evidence used in health technology assessment (HTA) agency reports has been considered essential for decision-making processes and their legitimacy. In Brazil, CONITEC is the agency responsible for defining data mandatory for the submission of proposals for the incorporation of new technologies. The objective of this study was to analyse CONITEC recommendation reports, the type of scientific evidence used in them and their compliance with operational procedures...
May 11, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29751085/a-predictive-index-of-biomarkers-for-ictogenesis-from-tier-i-safety-pharmacology-testing-that-may-warrant-tier-ii-eeg-studies
#10
REVIEW
David V Gauvin, Zachary J Zimmermann, Joshua Yoder, Marci Harter, David Holdsworth, Quinn Kilgus, Jonelle May, Jill Dalton, Theodore J Baird
Three significant contributions to the field of safety pharmacology were recently published detailing the use of electroencephalography (EEG) by telemetry in a critical role in the successful evaluation of a compound during drug development (1] Authier, Delatte, Kallman, Stevens & Markgraf; JPTM 2016; 81:274-285; 2] Accardi, Pugsley, Forster, Troncy, Huang & Authier; JPTM; 81: 47-59; 3] Bassett, Troncy, Pouliot, Paquette, Ascaha, & Authier; JPTM 2016; 70: 230-240) . These authors present a convincing case for monitoring neocortical biopotential waveforms (EEG, ECoG, etc) during preclinical toxicology studies as an opportunity for early identification of a central nervous system (CNS) risk during Investigational New Drug (IND) Enabling Studies...
May 8, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29748120/diversity-of-coxiella-like-and-francisella-like-endosymbionts-and-rickettsia-spp-coxiella-burnetii-as-pathogens-in-the-tick-populations-of-slovakia-central-europe
#11
Eva Špitalská, Olivier Sparagano, Michal Stanko, Katarína Schwarzová, Zdenko Špitalský, Ľudovít Škultéty, Sabína Fumačová Havlíková
Ticks are important vectors of pathogens affecting humans and animals worldwide. They do not only carry pathogens but diverse commensal and symbiotic microorganisms are also present in ticks. A molecular screening for tick-borne pathogens and endosymbionts was carried out in Ixodes ricinus, Dermacentor reticulatus and Haemaphysalis inermis questing ticks collected in Slovakia. The presence of Rickettsia spp., Coxiella burnetii, Coxiella-like and Francisella-like microorganisms was evaluated by PCR in 605 individuals and by randomly sequencing 66 samples...
May 3, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29744972/are-socio-emotional-and-neurocognitive-functioning-predictors-of-therapeutic-outcomes-for-adults-with-anorexia-nervosa
#12
Anna Oldershaw, Tony Lavender, Ulrike Schmidt
BACKGROUND: Emotional, social, and neurocognitive factors are theorised to maintain anorexia nervosa (AN). Yet whether they predict outcomes or relate to clinical change remains unclear. METHODS: Seventy-one consecutive adult outpatient eating disorder service referrals presenting with AN, who participated in a randomised controlled trial comparing 2 psychotherapies, were assessed for emotional processing, social cognition, and neurocognition pretherapy and posttherapy...
May 10, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29744971/psychosocial-roots-of-paranoid-ideation-the-role-of-childhood-experiences-social-comparison-submission-and-shame
#13
Célia Barreto Carvalho, Carolina da Motta, José Pinto-Gouveia, Ermelindo Peixoto
BACKGROUND: Social experiences have a significant impact on cognitive functioning and appraisals of social interactions. Specifically, recalls of antipathy from parents, submissiveness, and bullying during childhood can have a significant influence on paranoid ideation later in life. METHOD: Multiple hierarchical regression analysis was performed on a sample of 91 patients diagnosed with paranoid schizophrenia in remission and active phase, their first-degree relatives (n = 32) and unaffected controls (n = 64)...
May 9, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29744918/retrospective-analysis-of-rf-heating-measurements-of-passive-medical-implants
#14
Ting Song, Zhiheng Xu, Maria Ida Iacono, Leonardo M Angelone, Sunder Rajan
PURPOSE: The test reports for the RF-induced heating of metallic devices of hundreds of medical implants have been provided to the U.S. Food and Drug Administration as a part of premarket submissions. The main purpose of this study is to perform a retrospective analysis of the RF-induced heating data provided in the reports to analyze the trends and correlate them with implant geometric characteristics. METHODS: The ASTM-based RF heating test reports from 86 premarket U...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29742930/reporting-qualitative-research-standards-challenges-and-implications-for-health-design
#15
Kathryn Peditto
OBJECTIVE: This Methods column describes the existing reporting standards for qualitative research, their application to health design research, and the challenges to implementation. Intended for both researchers and practitioners, this article provides multiple perspectives on both reporting and evaluating high-quality qualitative research. BACKGROUND: Two popular reporting standards exist for reporting qualitative research-the Consolidated Criteria for Reporting Qualitative Research (COREQ) and the Standards for Reporting Qualitative Research (SRQR)...
January 1, 2018: HERD
https://www.readbyqxmd.com/read/29730448/a-big-data-approach-to-the-concordance-of-the-toxicity-of-pharmaceuticals-in-animals-and-humans
#16
Matthew Clark
Although lack of efficacy is an important cause of late stage attrition in drug development the shortcomings in the translation of toxicities observed during the preclinical development to observations in clinical trials or post-approval is an ongoing topic of research. The concordance between preclinical and clinical safety observations has been analyzed only on relatively small data sets, mostly over short time periods of drug approvals. We therefore explored the feasibility of a big-data analysis on a set of 3290 approved drugs and formulations for which 1,637,449 adverse events were reported for both humans animal species in regulatory submissions over a period of more than 70 years...
May 3, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29729747/quality-submissions-and-editorial-commentaries-require-heavy-lifting-journal-growth-risks-information-overload
#17
EDITORIAL
James H Lubowitz, Jefferson C Brand, Michael J Rossi
Our journal has grown in pages including more articles plus commentary. On the one hand, we see this as a subscriber benefit, but we also recognize that more is not always better. We risk information overload resulting in fatigue and the inability to read every word of every article. The challenge of information overload has expanded since the explosion of the internet and electronic communications. We could increase our already high rejection rates, but at the risk of rejecting high-quality research, which we do not prefer...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29729106/problems-and-challenges-of-predatory-journals
#18
REVIEW
Georg Richtig, Marina Berger, Bernhard Lange-Asschenfeldt, Werner Aberer, Erika Richtig
The companies publishing predatory journals are an emerging problem in the area of scientific literature since they only seek to drain money from authors without providing any customer service for the authors or their readership. These predatory journals try to attract new submissions by aggressive email advertising and high acceptance rates. But in turn, they do not provide proper peer-review and therefore the scientific quality of submitted articles is questionable. This is important because more and more people, including patients, are reading such journals and rely on the information they provide...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29728819/the-changing-tides-of-irish-orthopaedic-research
#19
Ailbhe White Gibson, Kevin Clesham, Oisin Tully, John F Quinlan
INTRODUCTION: Research is fundamental to bridging theory, practice and education in orthopaedics. Following the restructuring of the surgical training pathway in Ireland, the opportunity to undertake clinical- or lab-based research has fallen. AIMS: Our aim was to investigate the trends of research in orthopaedics and the implications there. METHODS: We reviewed the trend in publications by Irish trauma and orthopaedic (T&O) trainees over the past 20 years across three different classes of journal...
May 4, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29725997/population-pharmacokinetic-pharmacodynamic-analysis-of-alirocumab-in-healthy-volunteers-or-hypercholesterolemic-subjects-using-an-indirect-response-model-to-predict-low-density-lipoprotein-cholesterol-lowering-support-for-a-biologics-license-application-submission
#20
Xavier Nicolas, Nassim Djebli, Clémence Rauch, Aurélie Brunet, Fabrice Hurbin, Jean-Marie Martinez, David Fabre
BACKGROUND: Alirocumab, a human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly lowers low-density lipoprotein cholesterol levels. OBJECTIVE: This analysis aimed to develop and qualify a population pharmacokinetic/pharmacodynamic model for alirocumab based on pooled data obtained from 13 phase I/II/III clinical trials. METHODS: From a dataset of 2799 individuals (14,346 low-density lipoprotein-cholesterol values), individual pharmacokinetic parameters from the population pharmacokinetic model presented in Part I of this series were used to estimate alirocumab concentrations...
May 3, 2018: Clinical Pharmacokinetics
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