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https://www.readbyqxmd.com/read/28925287/assessing-and-developing-the-written-reflective-practice-skills-of-speech-language-pathology-students
#1
Kate Cook, Gina Tillard, Christine Wyles, Daniel Gerhard, Tika Ormond, Megan McAuliffe
PURPOSE: Written reflective practice aims to support critical thinking and problem solving skills in speech-language pathology (SLP) clinical education programmes. Yet, there has been limited investigation of students' development of written reflective practice skills over time and during a real-time clinical experience. The purpose of this study was to investigate students' development of breadth and depth of written reflective practice across a six-week clinical experience. METHOD: Participants were 59 undergraduate and 14 postgraduate SLP students...
September 19, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28924496/challenging-a-bioinformatic-tool-s-ability-to-detect-microbial-contaminants-using-in-silico-whole-genome-sequencing-data
#2
Nathan D Olson, Justin M Zook, Jayne B Morrow, Nancy J Lin
High sensitivity methods such as next generation sequencing and polymerase chain reaction (PCR) are adversely impacted by organismal and DNA contaminants. Current methods for detecting contaminants in microbial materials (genomic DNA and cultures) are not sensitive enough and require either a known or culturable contaminant. Whole genome sequencing (WGS) is a promising approach for detecting contaminants due to its sensitivity and lack of need for a priori assumptions about the contaminant. Prior to applying WGS, we must first understand its limitations for detecting contaminants and potential for false positives...
2017: PeerJ
https://www.readbyqxmd.com/read/28922742/glytoucan-an-accessible-glycan-structure-repository
#3
Michael Tiemeyer, Kazuhiro Aoki, James Paulson, Richard D Cummings, William S York, Niclas G Karlsson, Frederique Lisacek, Nicolle H Packer, Matthew P Campbell, Nobuyuki P Aoki, Akihiro Fujita, Masaaki Matsubara, Daisuke Shinmachi, Shinichiro Tsuchiya, Issaku Yamada, Michael Pierce, René Ranzinger, Hisashi Narimatsu, Kiyoko F Aoki-Kinoshita
Rapid and continued growth in the generation of glycomic data has revealed the need for enhanced development of basic infrastructure for presenting and interpreting these datasets in a manner that engages the broader biomedical research community. Early in their growth, the genomic and proteomic fields implemented mechanisms for assigning unique gene and protein identifiers that were essential for organizing data presentation and for enhancing bioinformatic approaches to extracting knowledge. Similar unique identifiers are currently absent from glycomic data...
October 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28921878/simplifying-sampling-for-african-swine-fever-surveillance-assessment-of-antibody-and-pathogen-detection-from-blood-swabs
#4
J Carlson, L Zani, T Schwaiger, I Nurmoja, A Viltrop, A Vilem, M Beer, S Blome
African swine fever (ASF) is a notifiable disease with serious socio-economic consequences that has been present in wild boar in the Baltic States and Poland since 2014. An introduction of ASF is usually accompanied by increased mortality, making fallen wild boar and hunted animals with signs of disease the main target for early warning and passive surveillance. It is difficult, however, to encourage hunters and foresters to report and take samples from these cases. A pragmatic and easy sampling approach with quick-drying swabs could facilitate this...
September 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28921646/how-often-are-drugs-made-available-under-the-food-and-drug-administration-s-expanded-access-process-approved
#5
Amy E McKee, André O Markon, Kirk M Chan-Tack, Peter Lurie
In this review of individual patient expanded-access requests to the Center for Drug Evaluation and Research for the period Fiscal Year 2010 to Fiscal Year 2014, we evaluated the number of applications received and the number allowed to proceed. We also evaluated whether drugs and certain biologics obtained under expanded access went on to be approved by the Food and Drug Administration. Finally, we considered concerns that adverse events occurring during expanded access might place sponsors at risk for legal liability...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28921375/convex-pl-a-novel-knowledge-based-potential-for-protein-ligand-interactions-deduced-from-structural-databases-using-convex-optimization
#6
Maria Kadukova, Sergei Grudinin
We present a novel optimization approach to train a free-shape distance-dependent protein-ligand scoring function called Convex-PL. We do not impose any functional form of the scoring function. Instead, we decompose it into a polynomial basis and deduce the expansion coefficients from the structural knowledge base using a convex formulation of the optimization problem. Also, for the training set we do not generate false poses with molecular docking packages, but use constant RMSD rigid-body deformations of the ligands inside the binding pockets...
September 18, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28918665/considerations-in-establishing-bioequivalence-of-inhaled-compounds
#7
Irvin Mayers, Mohit Bhutani
Generic inhalers are often perceived as inferior to their branded counterparts; however, they are safe and effective if they can meet the regulatory requirements. The approach to assess bioequivalence (BE) in oral dosage form products is not sufficient to address the complexities of inhalational products (e.g., patient-device interface); hence, more considerations are needed and caution should be applied in determining BE of inhaled compounds. Areas covered: This review outlines the evaluation process for generic inhalers, explores the regulatory approaches in BE assessment, and highlights the considerations and challenges in the current in vitro and in vivo approaches (lung deposition, pharmacokinetic, pharmacodynamic/clinical studies, and patient-device interface) for establishing BE of inhaled compounds...
September 18, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28918599/optimal-affinity-ranking-for-automated-virtual-screening-validated-in-prospective-d3r-grand-challenges
#8
Bentley M Wingert, Rick Oerlemans, Carlos J Camacho
The goal of virtual screening is to generate a substantially reduced and enriched subset of compounds from a large virtual chemistry space. Critical in these efforts are methods to properly rank the binding affinity of compounds. Prospective evaluations of ranking strategies in the D3R grand challenges show that for targets with deep pockets the best correlations (Spearman ρ ~ 0.5) were obtained by our submissions that docked compounds to the holo-receptors with the most chemically similar ligand. On the other hand, for targets with open pockets using multiple receptor structures is not a good strategy...
September 16, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28918414/a-protocol-of-a-cross-sectional-study-evaluating-an-online-tool-for-early-career-peer-reviewers-assessing-reports-of-randomised-controlled-trials
#9
Anthony Chauvin, David Moher, Doug Altman, David L Schriger, Sabina Alam, Sally Hopewell, Daniel R Shanahan, Alessandro Recchioni, Philippe Ravaud, Isabelle Boutron
INTRODUCTION: Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early career peer reviewers who use an innovative online tool to the usual peer reviewer process in evaluating the completeness of reporting and switched primary outcomes in completed reports. METHODS AND ANALYSIS: This is a cross-sectional study of individual two-arm parallel-group randomised controlled trials (RCTs) published in the BioMed Central series medical journals, BMJ, BMJ Open and Annals of Emergency Medicine and indexed with the publication type 'Randomised Controlled Trial'...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28916468/dermal-absorption-for-pesticide-health-risk-assessment-harmonization-of-study-design-and-data-reporting-for-north-american-regulatory-submissions
#10
Kristie M Sullivan, Manoj Aggarwal, Jonathan M Akins, Eric Fabian, Jon R Heylings, Hans Raabe, P V Shah, Christiane Wiemann, Richard Peffer
Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach in North America for pesticide formulations has not occurred due to concern over the reliability and consistency of the in vitro results. A 2012 workshop convened a panel of experts in the conduct of in vitro studies used for pesticide risk assessment, together with North American regulators, to examine techniques for in vitro dermal absorption testing...
September 12, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28915514/developmental-stuttering-in-children-who-are-hard-of-hearing
#11
Richard M Arenas, Elizabeth A Walker, Jacob J Oleson
Purpose: A number of studies with large sample sizes have reported lower prevalence of stuttering in children with significant hearing loss compared to children without hearing loss. This study used a parent questionnaire to investigate the characteristics of stuttering (e.g., incidence, prevalence, and age of onset) in children who are hard of hearing (CHH). Method: Three hundred three parents of CHH who participated in the Outcomes of Children With Hearing Loss study (Moeller & Tomblin, 2015) were sent questionnaires asking about their child's history of stuttering...
September 15, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28914440/olaratumab-in-combination-with-doxorubicin-for-the-treatment-of-advanced-soft-tissue-sarcoma-an-evidence-review-group-perspective-of-a-national-institute-for-health-and-care-excellence-single-technology-appraisal
#12
REVIEW
Irina A Tikhonova, Tracey Jones-Hughes, James Dunham, Fiona C Warren, Sophie Robinson, Peter Stephens, Martin Hoyle
The manufacturer of olaratumab (Lartruvo(®)), Eli Lilly & Company Limited, submitted evidence for the clinical and cost effectiveness of this drug, in combination with doxorubicin, for untreated advanced soft tissue sarcoma (STS) not amenable to surgery or radiotherapy, as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal process. The Peninsula Technology Assessment Group, commissioned to act as the Evidence Review Group (ERG), critically reviewed the company's submission...
September 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28913782/docking-of-small-molecules-to-farnesoid-x-receptors-using-autodock-vina-with-the-convex-pl-potential-lessons-learned-from-d3r-grand-challenge-2
#13
Maria Kadukova, Sergei Grudinin
The 2016 D3R Grand Challenge 2 provided an opportunity to test multiple protein-ligand docking protocols on a set of ligands bound to farnesoid X receptor that has many available experimental structures. We participated in the Stage 1 of the Challenge devoted to the docking pose predictions, with the mean RMSD value of our submission poses of 2.9 Å. Here we present a thorough analysis of our docking predictions made with AutoDock Vina and the Convex-PL rescoring potential by reproducing our submission protocol and running a series of additional molecular docking experiments...
September 14, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28913743/predicting-the-affinity-of-farnesoid-x-receptor-ligands-through-a-hierarchical-ranking-protocol-a-d3r-grand-challenge-2-case-study
#14
Manon Réau, Florent Langenfeld, Jean-François Zagury, Matthieu Montes
The Drug Design Data Resource (D3R) Grand Challenges are blind contests organized to assess the state-of-the-art methods accuracy in predicting binding modes and relative binding free energies of experimentally validated ligands for a given target. The second stage of the D3R Grand Challenge 2 (GC2) was focused on ranking 102 compounds according to their predicted affinity for Farnesoid X Receptor. In this task, our workflow was ranked 5th out of the 77 submissions in the structure-based category. Our strategy consisted in (1) a combination of molecular docking using AutoDock 4...
September 14, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28905648/personhood-dementia-policy-and-the-irish-national-dementia-strategy
#15
Niamh Hennelly, Eamon O'Shea
Personhood and its realisation in person-centred care is part of the narrative, if not always the reality, of care for people with dementia. This paper examines how personhood is conceptualised and actualised in Ireland through a content analysis of organisational and individual submissions from stakeholders in the development of the Irish National Dementia Strategy, followed by an examination of the Strategy itself. The organisational submissions are further categorised into dementia care models. A structural analysis of the Strategy examines its principles, actions and outcomes in relation to personhood...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28902887/a-checklist-is-associated-with-increased-quality-of-reporting-preclinical-biomedical-research-a-systematic-review
#16
SeungHye Han, Tolani F Olonisakin, John P Pribis, Jill Zupetic, Joo Heung Yoon, Kyle M Holleran, Kwonho Jeong, Nader Shaikh, Doris M Rubio, Janet S Lee
Irreproducibility of preclinical biomedical research has gained recent attention. It is suggested that requiring authors to complete a checklist at the time of manuscript submission would improve the quality and transparency of scientific reporting, and ultimately enhance reproducibility. Whether a checklist enhances quality and transparency in reporting preclinical animal studies, however, has not been empirically studied. Here we searched two highly cited life science journals, one that requires a checklist at submission (Nature) and one that does not (Cell), to identify in vivo animal studies...
2017: PloS One
https://www.readbyqxmd.com/read/28902400/using-the-pride-database-and-proteomexchange-for-submitting-and-accessing-public-proteomics-datasets
#17
Andrew F Jarnuczak, Juan Antonio Vizcaíno
The ProteomeXchange (PX) Consortium is the unifying framework for world-leading mass spectrometry (MS)-based proteomics repositories. Current members include the PRIDE database (U.K.), PeptideAtlas/PASSEL, and MassIVE (U.S.A.), and jPOST (Japan). The Consortium standardizes submission and dissemination of public proteomics data worldwide. This is achieved through implementing common data submission guidelines and enforcing metadata requirements by each of the members. Furthermore, the members use a common identifier space...
September 13, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28901589/the-subcons-web-server-a-user-friendly-web-interface-for-state-of-the-art-subcellular-localization-prediction
#18
M Salvatore, N Shu, A Elofsson
SubCons is a recently developed method that predicts the subcellular localisation of a protein. It combines predictions from four predictors using a Random Forest classifier. Here, we present the user-friendly web-interface implementation of SubCons. Starting from a protein sequence, the server rapidly predicts the subcellular localisations of an individual protein. Additionally, the server accepts the submission of sets of proteins either by uploading the files or programmatically by using command line WSDL API scripts...
September 13, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28900792/relative-binding-affinity-prediction-of-farnesoid-x-receptor-in-the-d3r-grand-challenge-2-using-fep
#19
Christina Schindler, Friedrich Rippmann, Daniel Kuhn
Physics-based free energy simulations have increasingly become an important tool for predicting binding affinity and the recent introduction of automated protocols has also paved the way towards a more widespread use in the pharmaceutical industry. The D3R 2016 Grand Challenge 2 provided an opportunity to blindly test the commercial free energy calculation protocol FEP+ and assess its performance relative to other affinity prediction methods. The present D3R free energy prediction challenge was built around two experimental data sets involving inhibitors of farnesoid X receptor (FXR) which is a promising anticancer drug target...
September 12, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28898128/technologist-directed-repeat-musculoskeletal-and-chest-radiographs-how-often-do-they-impact-diagnosis
#20
Andrew B Rosenkrantz, Jill E Jacobs, Nidhi Jain, Geraldine Brusca-Augello, Michael Mechlin, Marc Parente, Michael P Recht
OBJECTIVE: Radiologic technologists may repeat images within a radiographic examination because of perceived suboptimal image quality, excluding these original images from submission to a PACS. This study assesses the appropriateness of technologists' decisions to repeat musculoskeletal and chest radiographs as well as the utility of repeat radiographs in addressing examinations' clinical indication. MATERIALS AND METHODS: We included 95 musculoskeletal and 87 chest radiographic examinations in which the technologist repeated one or more images because of perceived image quality issues, rejecting original images from PACS submission...
September 12, 2017: AJR. American Journal of Roentgenology
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