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https://www.readbyqxmd.com/read/28732261/predictors-of-disclosure-management-behavior-at-the-end-of-1-year-follow-up-in-korean-adults-with-newly-diagnosed-epilepsy
#1
Sang-Ahm Lee, Soon-Kee No, Hyungkook Park, Ok-Joon Kim, Jee-Hyun Kwon, Ji-Yeon Ryu, Sang-Moo Lee, Kwang-Deog Jo
PURPOSE: Epilepsy is a concealable stigmatizing condition. We investigated the factors predicting disclosure management behavior in Korean adults with newly diagnosed epilepsy. METHODS: This longitudinal multicenter study included Korean adults with newly diagnosed epilepsy. Using statistical analyses, we determined at the end of a 1-year follow-up whether Disclosure Management Scale (DMS) scores were predicted by demographic, clinical, and psychosocial variables, including felt stigma, stress coping style, personality traits, social support, and experienced discrimination from society...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28726800/role-of-nicotinamide-n-methyltransferase-in-dorsal-striatum-in-cocaine-place-preference
#2
Li Luo, Fei-Fei Shang, Hailei Long, Linhong Jiang, Ruiming Zhu, Qian Zhao, Hui Gu, Jueying Kong, Wei Xu, Yinglan Zhao, Xiaobo Cen
Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). NNMT has been implicated in a variety of diseases; however, the role of NNMT in drug addiction is largely unknown. Here, we found that the expression of Nnmt was significantly upregulated in the dorsal striatum (DS) of cocaine-conditioned mice. Cocaine significantly decreased SAM/SAH ratio levels in the DS, which was accompanied with the decreased activities of Rac1 and RhoA...
July 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28715183/dimethyl-sulfoxide-complexes-detected-at-ambient-conditions
#3
Anne Schou Hansen, Henrik Grum Kjaergaard
Dimethyl sulfoxide (DMSO) is an important intermediate in the atmospheric oxi- dation of dimethyl sulfide (DMS). DMS, emitted from the ocean, is the main natural sulfur source and its oxidation products are essential in the formation of sulfate aerosols. The high atmospheric concentration of water makes hydrogen bonding with DMS and its oxidation products likely. Through hydrogen bonding, water can potentially cat- alyze and affect the steps of the oxidation. We investigate binary hydrogen bound complexes involving DMSO...
July 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28713248/deep-brain-magnetic-stimulation-promotes-neurogenesis-and-restores-cholinergic-activity-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#4
Junli Zhen, Yanjing Qian, Jian Fu, Ruijun Su, Haiting An, Wei Wang, Yan Zheng, Xiaomin Wang
Alzheimer's disease (AD) is characterized by progressive decline of memory and cognitive functions. Deep magnetic stimulation (DMS), a noninvasive and nonpharmacological brain stimulation, has been reported to alleviate stress-related cognitive impairment in neuropsychiatric disorders. Our previous study also discovered the preventive effect of DMS on cognitive decline in an AD mouse model. However, the underlying mechanism must be explored further. In this study, we investigated the effect of DMS on spatial learning and memory functions, neurogenesis in the dentate gyrus (DG), as well as expression and activity of the cholinergic system in a transgenic mouse model of AD (5XFAD)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28711684/folding-of-the-silver-aptamer-in-a-dnazyme-probed-by-2-aminopurine-fluorescence
#5
Runjhun Saran, Lu Yao, Peter Hoang, Juewen Liu
The RNA-cleaving Ag10c DNAzyme was recently isolated via in vitro selection and it can bind two Ag(+) ions for activity. The Ag10c contains a well-defined Ag(+) binding aptamer as indicated by DMS footprinting. Since aptamer binding is often accompanied with conformational changes, we herein used 2-aminopurine (2AP) to probe its folding in the presence of Ag(+). The Ag10c was respectively labeled with 2AP at three different positions, both in the substrate strand and in the enzyme strand. Ag(+)-induced folding was observed at the substrate cleavage junction and the A9 position of the enzyme strand, consistent with aptamer binding...
July 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28708670/color-pupillography-in-dorsal-midbrain-syndrome
#6
Carina B Kelbsch, Fumiatsu Maeda, Torsten Strasser, Tobias M Peters, Barbara J C Wilhelm, Helmut M Wilhelm
OBJECTIVE: The purpose of this study was to evaluate the pupil response to chromatic stimuli in patients with lesions in the dorsal midbrain and possibly gain new insights into the afferent pupillary pathways. METHODS: Color pupillography was performed in 5 patients with dorsal midbrain syndrome (DMS), and their results were compared with those of 20 healthy control subjects. We used full-field red stimuli (605 nm) that primarily address the rod/cone system and blue stimuli (420 nm) that preferentially activate intrinsically photosensitive retinal ganglion cells (ipRGCs) directly, with a duration of 4 seconds and a stimulus intensity of 28 lx corneal illumination under mesopic conditions...
July 13, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28704484/apoptosis-by-pt-o-o-acac-%C3%AE-acac-dms-requires-pkc-%C3%AE-mediated-p53-activation-in-malignant-pleural-mesothelioma
#7
Antonella Muscella, Carla Vetrugno, Luca Giulio Cossa, Giovanna Antonaci, Amilcare Barca, Sandra Angelica De Pascali, Francesco Paolo Fanizzi, Santo Marsigliante
Mesothelioma cancer cells have epithelioid or sarcomatoid morphology. The worst prognosis is associated with sarcomatoid phenotype and resistance to therapy is affected by cells heterogeneity. We recently showed that in ZL55 mesothelioma cell line of epithelioid origin [Pt(O,O'-acac)(γ-acac)(DMS)] (Ptac2S) has an antiproliferative effect in vitro and in vivo. Aim of this work was to extend the study on the effects of Ptac2S on ZL34 cell line, representative of sarcomatoid mesothelioma. ZL34 cells were used to assay the antitumor activity of Ptac2S in a mouse xenograft model in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28691722/potential-role-of-dopamine-transporter-in-behavioral-flexibility
#8
Anita Cybulska-Klosowicz, Julia Dabrowska, Sebastian Niedzielec, Renata Zakrzewska, Aleksandra Rozycka
Behavioral flexibility is subserved by the prefrontal cortex and the basal ganglia. Orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) form a functional frontocorticostriatal circuit crucial for the mediation of flexibility during reversal learning via dopamine (DA) neurotransmission. The regulatory control in maintaining DA homeostasis and function is provided by the dopamine transporter (DAT), which therefore likely plays a significant role in controlling the influence of DA on cognitive processes...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28687647/the-deep-sea-bacterium-shewanella-piezotolerans-wp3-has-two-dmso-reductases-in-distinct-subcellular-locations
#9
Lei Xiong, Huahua Jian, Xiang Xiao
Dimethyl sulfoxide (DMSO) acts as a substantial sink for dimethyl sulfide (DMS) in deep waters and is therefore considered a potential electron acceptor supporting abyssal ecosystems. Shewanella piezotolerans WP3 was isolated from west Pacific deep-sea sediments, and two functional DMSO respiratory subsystems are essential for maximum growth of WP3 under in situ conditions (4°C/20 MPa). However, the relationship between these two subsystems and the electron transport pathway underlying DMSO reduction by WP3 remain unknown...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28683918/enzymology-of-microbial-dimethylsulfoniopropionate-catabolism
#10
Mishtu Dey
The biochemistry of dimethylsulfoniopropionate (DMSP) catabolism is reviewed. The microbes that catalyze the reactions central to DMSP catabolic pathways are described, and the focus is on the enzymology of the process. Approximately 10(9)tons of DMSP is released annually by marine eukaryotes as an osmolyte. A vast majority of DMSP is assimilated by bacteria through either a demethylation or lyase pathways, producing either the methane thiol or the volatile dimethylsulfide (DMS), respectively. Enzymatic breakdown of DMSP generates ~10(7)tons of DMS annually, which may have impact on global climate...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28680003/the-relationship-between-sleep-disturbances-and-depression-in-daytime-workers-a-cross-sectional-structured-interview-survey
#11
Hiroki Ikeda, Kotaro Kayashima, Takeshi Sasaki, Sachiko Kashima, Fumihiko Koyama
The aim of this study was to clarify the relationship between sleep disturbances and depression in daytime workers using a structured interview. A total of 1184 daytime workers were enrolled. We evaluated difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), early morning awakening (EMA), and global insomnia scores (ISs) in all participants. As a result, the prevalences of DIS, DMS, and EMA were 16%, 46%, and 22 %, respectively. IS was significantly correlated with depression score. Additionally, although all IS subscales (i...
July 6, 2017: Industrial Health
https://www.readbyqxmd.com/read/28677359/efficacy-of-nasal-cellulose-powder-in-the-symptomatic-treatment-of-allergic-rhinitis-a-randomized-double-blind-placebo-controlled-trial
#12
Wiparat Manuyakorn, Natchanun Klangkalya, Wasu Kamchaisatian, Suwat Benjaponpita, Cherapat Sasisakulporn, Wanlapa Jotikasthira
PURPOSE: Nasal Cellulose Powder (NCP), which can prevent from binding an allergen to nasal mucosa, may reduce allergic rhinitis (AR) symptoms in dust mite-sensitized children. This study was conducted to assess the efficacy of NCP in improving clinical symptoms of a nasal airflow limitation and the response of nasal inflammatory cells. METHODS: Children with dust mite-sensitized AR aged 6-18 years were recruited. After a 4-week run-in period, NCP or a placebo was administered, 1 puff per nostril 3 times daily for 4 weeks...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28674758/dimethyl-sulfide-emission-behavior-from-landfill-site-with-air-and-water-control
#13
Yuyang Long, Siyuan Zhang, Yuan Fang, Yao Du, Weijia Liu, Chengran Fang, Dongsheng Shen
Municipal solid waste landfills are responsible for odors affecting the environment and human health. Dimethyl sulfide (DMS) is one of the major odorous compounds known for its low odor threshold and wide distribution. This study examined the generation, migration and emission of DMS in four artificial landfill-simulating reactors: Reactor 1 and Reactor 2, running under anaerobic and semi-aerobic conditions, respectively, without leachate recirculation; and Reactor 3 and Reactor 4, running under anaerobic and semi-aerobic conditions, respectively, with leachate recirculation...
July 3, 2017: Biodegradation
https://www.readbyqxmd.com/read/28672951/hypothalamic-pituitary-adrenal-axis-hypersensitivity-in-female-rats-on-a-post-weaning-high-fat-diet-after-chronic-mild-stress
#14
Lian Liu, Junqiang Yang, Feng Qian, Chengbiao Lu
A high-fat diet (HFD) is highly correlated to obesity, metabolic diseases and certain behavioral changes. However, the effects of post-weaning HFD in rats during puberty and the role of the hypothalamic-pituitary-adrenal (HPA) axis in this process have remained elusive. The present study hypothesized that the HPA axis mediates the behavioral alterations induced by a post-weaning HFD. To investigate this, female rats were divided into two groups, one of which was fed a HFD from postnatal weeks (PWs) 4-12, while the other group received standard chow...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28667174/erbb4-deletion-from-medium-spiny-neurons-of-the-nucleus-accumbens-core-induces-schizophrenia-like-behaviors-via-elevated-gabaar-%C3%AE-1-expression
#15
Hong-Yan Geng, Jing Zhang, Jian-Ming Yang, Yue Li, Ning Wang, Mao Ye, Xiao-Juan Chen, Hong Lian, Xiao-Ming Li
Medium spiny neurons (MSNs), the major GABAergic projection neurons in the striatum, are implicated in many neuropsychiatric diseases, such as schizophrenia, but the underlying mechanisms remain unclear. We found that a deficiency in Erbb4, a schizophrenia risk gene, in MSNs of the nucleus accumbens (NAc) core but not the dorsomedial striatum (DMS) markedly induced schizophrenia-like behaviors such as hyperactivity, abnormal marble-burying behavior, damaged social novelty recognition and impaired sensorimotor gating function in male mice...
June 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28666531/the-influence-of-ocean-halogen-and-sulfur-emissions-in-the-air-quality-of-a-coastal-megacity-the-case-of-los-angeles
#16
Maria Muñiz-Unamunzaga, Rafael Borge, Golam Sarwar, Brett Gantt, David de la Paz, Carlos A Cuevas, Alfonso Saiz-Lopez
The oceans are the main source of natural halogen and sulfur compounds, which have a significant influence on the oxidizing capacity of the marine atmosphere; however, their impact on the air quality of coastal cities is currently unknown. We explore the effect of marine halogens (Cl, Br and I) and dimethyl sulfide (DMS) on the air quality of a large coastal city through a set of high-resolution (4-km) air quality simulations for the urban area of Los Angeles, US, using the Community Multiscale Air Quality (CMAQ model)...
June 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28664477/maximizing-ion-transmission-in-differential-mobility-spectrometry
#17
Bradley B Schneider, Frank Londry, Erkinjon G Nazarov, Yang Kang, Thomas R Covey
We provide modeling and experimental data describing the dominant ion-loss mechanisms for differential mobility spectrometry (DMS). Ion motion is considered from the inlet region of the mobility analyzer to the DMS exit, and losses resulting from diffusion to electrode surfaces, insufficient effective gap, ion fragmentation, and fringing field effects are considered for a commercial DMS system with 1-mm gap height. It is shown that losses due to diffusion and radial oscillations can be minimized with careful consideration of residence time, electrode spacing, gas flow rate, and waveform frequency...
June 29, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28662850/patient-dose-monitoring-systems-a-new-way-of-managing-patient-dose-and-quality-in-the-radiology-department
#18
N Fitousi
PURPOSE: Due to the upcoming European Directive (2013/59/EURATOM) and the increased focus on patient safety in international guidelines and regulations, Patient Dose Monitoring Systems, also called Dose Management Systems (DMS), are introduced in medical imaging departments. This article focusses on the requirements for a DMS, its benefits and the necessary implementation steps. METHOD: The implementation of a DMS can be perceived as a lengthy, yet worthy, procedure: users have to select the appropriate system for their applications, prepare data collection, validate, perform configuration, and start using the results in quality improvement projects...
June 26, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28660739/pooled-efficacy-and-safety-data-for-house-dust-mite-sublingual-immunotherapy-tablets-in-adolescents
#19
Tomokazu Matsuoka, David I Bernstein, Keisuke Masuyama, Hendrik Nolte, Kazuhiro Okamiya, Dorthe Seitzberg, Harold S Nelson
BACKGROUND: House dust mite (HDM) respiratory allergy is a common and burdensome disease in children and adolescents. There are few HDM allergy immunotherapy trials in children with perennial allergic rhinitis. This post hoc analysis used pooled data to evaluate efficacy and safety of the SQ HDM sublingual immunotherapy (SLIT) tablet in adolescents (12-17 years). METHODS: In 2 double-blind, placebo-controlled trials conducted in North America and Japan, respectively, subjects aged 12+ years with HDM allergic rhinitis were randomized to up to one year of treatment...
June 29, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28660337/differential-mobility-spectrometry-tandem-mass-spectrometry-with-multiple-ion-monitoring-for-the-bioanalysis-of-liraglutide
#20
Xiangjun Meng, Haitong Xu, Zhi Zhang, John Paul Fawcett, Junru Li, Yan Yang, Jingkai Gu
Liraglutide is a glucagon-like peptide-1 analog for the treatment of type 2 diabetes. Major interference in plasma of human and animals and low fragment signal in tandem mass spectrometry are the main difficulties encountered in the bioanalysis of liraglutide. In this study, by combining differential mobility spectrometry (DMS) with multiple ion monitoring detection (MIM), a liquid chromatography differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring detection (LC-DMS-MIM) method was developed for the quantitation of liraglutide in dog plasma...
June 28, 2017: Analytical and Bioanalytical Chemistry
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