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https://www.readbyqxmd.com/read/28320154/advances-in-assessing-myotonia-can-sensor-engineered-glove-have-a-role
#1
Simona Portaro, Margherita Russo, Antonino Naro, Alessia Bramanti, Placido Bramanti, Carmelo Rodolico, Rocco Salvatore Calabrò
Non-dystrophic (NDMs) and Dystrophic Myotonias (DMs) are diseases characterized by the presence of myotonia with or without muscle weakness. A standardized myotonia assessment is important to more objectively quantify the handgrip myotonia. We screened 10 patients affected by NDM and 10 patients with DM, using the sensor-engineered glove (SEG). The time required to perform a complete finger extension (grip myotonia time, GMT) at maximum velocity (MV) after maximum voluntary contraction (MVC) was evaluated through an ad hoc protocol including rest, exercise, and ice effects on handgrip myotonia...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28303968/sex-differences-in-dna-methylation-of-the-cord-blood-are-related-to-sex-bias-psychiatric-diseases
#2
Mariana Maschietto, Laura Caroline Bastos, Ana Carolina Tahira, Elen Pereira Bastos, Veronica Luiza Vale Euclydes, Alexandra Brentani, Günther Fink, Angelica de Baumont, Aloísio Felipe-Silva, Rossana Pulcineli Vieira Francisco, Gisele Gouveia, Sandra Josefina Ferraz Ellero Grisi, Ana Maria Ulhoa Escobar, Carlos Alberto Moreira-Filho, Guilherme Vanoni Polanczyk, Euripedes Constantino Miguel, Helena Brentani
Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and with appropriate weight at birth regarding their potential connection to psychiatric outcomes. Mothers were interviewed to gather information about environmental factors (gestational exposure) that could interfere with the methylation profiles in the newborns...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295771/analysis-of-17%C3%AE-estradiol-estriol-and-estrone-in-american-eel-anguilla-rostrata-tissue-samples-using-liquid-chromatography-coupled-to-electrospray-differential-ion-mobility-tandem-mass-spectrometry
#3
Alejandro Cohen, Neil W Ross, Paul M Smith, James P Fawcett
RATIONALE: 17β-Estradiol (E2), estrone (E1) and estriol (E3) are steroid hormones responsible for the regulation of the female reproductive system. Estradiol is planned to be used to feminize eels in aquaculture in order to improve their size and marketability. The residual levels of these hormones in fish tissue must be monitored to meet the requirements of food regulatory agencies. Few studies have studied these hormones on complex biological matrices such as fish tissue. METHODS: We developed a method to analyze E1, E2 and E3 in fish tissue using liquid chromatography in combination with differential ion mobility spectrometry (DMS) and tandem mass spectrometry (MS/MS)...
March 11, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28280776/assessing-physicochemical-properties-of-drug-molecules-via-microsolvation-measurements-with-differential-mobility-spectrometry
#4
Chang Liu, J C Yves Le Blanc, Bradley B Schneider, Jefry Shields, James J Federico, Hui Zhang, Justin G Stroh, Gregory W Kauffman, Daniel W Kung, Christian Ieritano, Evan Shepherdson, Mitch Verbuyst, Luke Melo, Moaraj Hasan, Dalia Naser, John S Janiszewski, W Scott Hopkins, J Larry Campbell
The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong local hydrogen bonding exists between the molecule and the solvent. One method that can probe the microsolvated states of charged molecules is differential mobility spectrometry (DMS), which rapidly interrogates an ion's transitions between a solvated and desolvated state in the gas phase (i...
February 22, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28270071/inhibitory-effects-of-novel-sphk2-inhibitors-on-migration-of-cancer-cells
#5
Deokho Jung, Junghyun Jung, Euiyeon Lee, Chang Soo Mok, Hyunjin Jeon, Chang Seo Park, Wonhee Jang, Youngeun Kwon
Cell migration is an essential process for survival and differentiation of mammalian cells. Numerous diseases are induced or influenced by inappropriate regulation of cell migration, which plays a key role in cancer cell metastasis. In fact, very few anti-metastasis drugs are available on the market. SphKs are enzymes that convert sphingosine to sphingosine-1- phosphate (S1P) and are known to control various cellular functions, including migration of cells. Among two human isozymes of SphK2, SphK2 is known to promote apoptosis, suppresses cell growth, and controls cell migration; in addition, the specific ablation of SphK2 activity was reported to inhibit cancer cell metastasis...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28261173/gut-microbial-diversity-assessment-of-indian-type-2-diabetics-reveals-alterations-in-eubacteria-archaea-and-eukaryotes
#6
Shrikant S Bhute, Mangesh V Suryavanshi, Suyog M Joshi, Chittaranjan S Yajnik, Yogesh S Shouche, Saroj S Ghaskadbi
Diabetes in India has distinct genetic, nutritional, developmental and socio-economic aspects; owing to the fact that changes in gut microbiota are associated with diabetes, we employed semiconductor-based sequencing to characterize gut microbiota of diabetic subjects from this region. We suggest consolidated dysbiosis of eubacterial, archaeal and eukaryotic components in the gut microbiota of newly diagnosed (New-DMs) and long-standing diabetic subjects (Known-DMs) compared to healthy subjects (NGTs). Increased abundance of phylum Firmicutes (p = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28260033/revealing-differential-modules-in-uveal-melanoma-by-analyzing-differential-networks
#7
Li Han, Cui Chen, Chang-Hui Liu, Min Zhang, Ling Liang
The aim of the present study was to investigate differential modules (DMs) between uveal melanoma (UM) and normal conditions by examining differential networks. Based on a gene expression profile collected from the ArrayExpress database, the inference of DMs involved three steps: The first step was construction of a differential co‑expression network (DCN); second, the module algorithm was adapted to identify the DMs presented in DCN; finally, the statistical significance of DMs were assessed based on the null score distribution of DMs generated using randomized networks...
February 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28255662/psychometric-evaluation-of-the-muscle-appearance-satisfaction-scale-in-a-mexican-male-sample
#8
María Del Consuelo Escoto Ponce de León, Lilián Elizabeth Bosques-Brugada, Esteban Jaime Camacho Ruiz, Georgina Alvarez-Rayón, Karina Franco Paredes, Gabriela Rodríguez Hernández
PURPOSE: The purpose of this study was to determine whether the muscle appearance satisfaction scale (MASS) shows acceptable psychometric properties in Mexican bodybuilders. METHODS: A total of 258 Mexican male bodybuilders were recruited. Two self-report questionnaires, including the MASS and drive for muscularity scale (DMS), were administered. Six models of the latent structure of the MASS were evaluated, using confirmatory factor analysis with maximum likelihood, considering robust Satorra-Bentler correction to estimate the fit of the models to the data...
March 2, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28242195/trade-off-between-dimethyl-sulfide-and-isoprene-emissions-from-marine-phytoplankton
#9
REVIEW
K G Srikanta Dani, Francesco Loreto
Marine phytoplankton emit volatile organic compounds (VOCs) such as dimethyl sulfide (DMS) and isoprene that influence air quality, cloud dynamics, and planetary albedo. We show that globally (i) marine phytoplankton taxa tend to emit either DMS or isoprene, and (ii) sea-water surface concentration and emission hotspots of DMS and isoprene have opposite latitudinal gradients. We argue that a convergence of antioxidant functions between DMS and isoprene is possible, driven by potential metabolic competition for photosynthetic substrates...
February 24, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28241640/software-compensation-method-for-achieving-high-stability-of-alpao-deformable-mirrors
#10
Urban Bitenc
Deformable mirrors (DMs) are used in adaptive optics for correcting optical aberrations: the DM surface can be deformed to compensate for them. Recently we reported the results on investigation of the stability of Alpao DMs, i.e. how accurately a DM surface shape can be maintained over minutes and hours without any optical feed-back. We observed a creep behavior of the DM surface and we presented a proof-of-concept software compensation for it, showing that very high stability is achievable. In this paper we develop a generalized creep compensation method that covers a wide range of DM use-cases and compensates for 90% - 95% of the creep observed...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28230255/changes-in-pectin-characteristics-during-the-ripening-of-jujube-fruit
#11
Shenghua Ding, Rongrong Wang, Yang Dan, Gaoyang Li, Shiyi Ou
BACKGROUND: Pectin is relative to fruit maturation and loss of flesh firmness. In this research, changes in pectin characteristics, including pectin content, neutral sugar compositions, molecular weight (Mw ) distribution, and degree of methyl esterification (DM), in six different growth stages (S1-S6) of jujube fruit were assessed. RESULTS: The growth of jujube fruit corresponded to an increase in water-soluble pectin (WSP), and a decrease in Na2 CO3 -soluble pectin (SSP)...
February 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28215084/effect-of-l-cysteine-and-transition-metal-ions-on-dimethyl-sulfide-oxidation
#12
Matthias Baldus, Rüdiger Klie, Xi De, Frank-Jürgen Methner
During malt kilning, significant amounts of dimethyl sulfide (DMS) oxidize leading to the formation of dimethyl sulfoxide (DMSO), a precursor of DMS during fermentation. Yet, knowledge regarding reaction mechanisms of DMSO formation during malt production is limited. The role of thiols in sulfide oxidation is unclear as they possess sulfoxide reducing ability as well as pro- and antioxidative properties. This study investigated the effects of the thiol l-cysteine (Cys), molecular oxygen, transition metal ions, and EDTA on DMS oxidation in aqueous model solutions...
March 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28201905/accurate-ab-initio-dipole-moment-surfaces-of-ozone-first-principle-intensity-predictions-for-rotationally-resolved-spectra-in-a-large-range-of-overtone-and-combination-bands
#13
Vladimir G Tyuterev, Roman V Kochanov, Sergey A Tashkun
Ab initio dipole moment surfaces (DMSs) of the ozone molecule are computed using the MRCI-SD method with AVQZ, AV5Z, and VQZ-F12 basis sets on a dense grid of about 1950 geometrical configurations. The analytical DMS representation used for the fit of ab initio points provides better behavior for large nuclear displacements than that of previous studies. Various DMS models were derived and tested. Vibration-rotation line intensities of (16)O3 were calculated from these ab initio surfaces by the variational method using two different potential functions determined in our previous works...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28192911/open-port-probe-sampling-interface-for-the-direct-coupling-of-biocompatible-solid-phase-microextraction-to-atmospheric-pressure-ionization-mass-spectrometry
#14
Germán Augusto Gómez-Ríos, Chang Liu, Marcos Tascon, Nathaly Reyes-Garcés, Don W Arnold, Thomas R Covey, Janusz Pawliszyn
In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential matrix effects when compared to direct injection to MS. In this study, we introduce the open port probe (OPP) as a robust interface to couple biocompatible SPME (Bio-SPME) fibers to MS systems for direct electrospray ionization. The presented design consisted of minimal alterations to the front-end of the instrument and provided better sensitivity, simplicity, speed, wider compound coverage, and high-throughput in comparison to the LC-MS based approach...
February 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191900/dimethylsulfoniopropionate-biosynthesis-in-marine-bacteria-and-identification-of-the-key-gene-in-this-process
#15
Andrew R J Curson, Ji Liu, Ana Bermejo Martínez, Robert T Green, Yohan Chan, Ornella Carrión, Beth T Williams, Sheng-Hui Zhang, Gui-Peng Yang, Philip C Bulman Page, Xiao-Hua Zhang, Jonathan D Todd
Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule(1), a key nutrient for marine microorganisms(2,3) and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways(4), is important in global sulfur cycling(2) and affects the Earth's albedo, and potentially climate, via sulfate aerosol and cloud condensation nuclei production(5,6). It was thought that only eukaryotes produce significant amounts of DMSP(7-9), but here we demonstrate that many marine heterotrophic bacteria also produce DMSP, probably using the same methionine (Met) transamination pathway as macroalgae and phytoplankton(10)...
February 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28185157/continuous-measurement-of-atmospheric-reduced-sulphur-compounds-as-key-tracers-between-odour-complaints-and-source-apportionment
#16
Maite de Blas, Marino Navazo, Lucio Alonso, Gotzon Gangoiti, José Antonio García, Estíbaliz Sáez de Cámara, Verónica Valdenebro, Estíbaliz García-Ruiz, Nicolás García-Borreguero
Odour complaints are frequent nowadays, particularly nearby industrial facilities emitting odorous compounds. Among all compounds susceptible of causing odour annoyance, reduced sulphur compounds (RSC) were studied, due to their unpleasant odour and low odour threshold. RSC ambient air mixing ratios, meteorological conditions and population complaints were analysed in an area of complex topography in order to identify their potential sources. Mixing ratios of three compounds, dimethyl sulphide (DMS), carbon disulphide (CDS) and dimethyl disulphide (DMDS), were continuously monitored using an online gas chromatograph coupled with a mass spectrometer detector (GC-MSD), which was placed in a mobile air quality monitoring unit...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28173653/-coenzyme-q-10-treatment-for-one-child-with-coq6-gene-mutation-induced-nephrotic-syndrome-and-literature-review
#17
Q Cao, G M Li, H Xu, Q Shen, L Sun, X Y Fang, H M Liu, W Guo, Y H Zhai, B B Wu
Objective: To summarize the clinical manifestation and molecular characteristics of COQ6 mutation induced nephrotic syndrome, and to evaluate efficacy of CoQ(10) therapy. Method: Clinical data of the case with infantile nephrotic syndrome was summarized, including clinical manifestations, laboratory findings and family investigation. The patient received CoQ(10) 30 mg/(kg·d) therapy. Urine protein/creatinine ratio, serum albumin and creatinine were detected to assess the efficacy of the therapy. Result: (1) The 10 months old boy was presented with nephrotic level proteinuria and hypoalbuminemia...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28158183/beyond-the-mhc-a-canine-model-of-dermatomyositis-shows-a-complex-pattern-of-genetic-risk-involving-novel-loci
#18
Jacquelyn M Evans, Rooksana E Noorai, Kate L Tsai, Alison N Starr-Moss, Cody M Hill, Kendall J Anderson, Thomas R Famula, Leigh Anne Clark
Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28147295/characteristics-of-the-horizontal-and-vertical-distributions-of-dimethyl-sulfide-throughout-the-amundsen-sea-polynya
#19
Intae Kim, Doshik Hahm, Keyhong Park, Youngju Lee, Jung-Ok Choi, Miming Zhang, Liqi Chen, Hyun-Cheol Kim, SangHoon Lee
We investigated horizontal and vertical distributions of DMS in the upper water column of the Amundsen Sea Polynya and Pine Island Polynya during the austral summer (January-February) of 2016 using a membrane inlet mass spectrometer (MIMS) onboard the Korean icebreaker R/V Araon. The surface water concentrations of DMS varied from <1 to 400nM. The highest DMS (up to 300nM) were observed in sea ice-polynya transition zones and near the Getz ice shelf, where both the first local ice melting and high plankton productivity were observed...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28132898/investigation-of-g-quadruplex-formation-in-the-fgfr2-promoter-region-and-its-transcriptional-regulation-by-liensinine
#20
Lulu Zhang, Wei Tan, Jiang Zhou, Ming Xu, Gu Yuan
BACKGROUND: Fibroblast growth factor receptor 2 (FGFR2) is overexpressed in breast cancer tissues and cells, and has been shown to be a susceptibility factor for breast cancer. In this study, we found that the G-rich sequences in the FGFR2 promoter region can form G-quadruplexes, which could be the target and inhibitor of the FGFR2 gene. METHODS: Initially, the formation of G-quadruplexes was confirmed by ESI-MS and CD, and DMS footprinting experiments gave the folding pattern of the G-quadruplexes...
April 2017: Biochimica et Biophysica Acta
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