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https://www.readbyqxmd.com/read/28647388/characterization-of-breast-masses-in-digital-breast-tomosynthesis-and-digital-mammograms-an-observer-performance-study
#1
Heang-Ping Chan, Mark A Helvie, Lubomir Hadjiiski, Deborah O Jeffries, Katherine A Klein, Colleen H Neal, Mitra Noroozian, Chintana Paramagul, Marilyn A Roubidoux
RATIONALE AND OBJECTIVES: This study aimed to compare Breast Imaging Reporting and Data System (BI-RADS) assessment of lesions in two-view digital mammogram (DM) to two-view wide-angle digital breast tomosynthesis (DBT) without DM. MATERIALS AND METHODS: With Institutional Review Board approval and written informed consent, two-view DBTs were acquired from 134 subjects and the corresponding DMs were collected retrospectively. The study included 125 subjects with 61 malignant (size: 3...
June 21, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28643537/a-diffusion-weighted-imaging-study-of-basal-ganglia-in-schizophrenia
#2
Giuseppe Delvecchio, Alessandro Pigoni, Cinzia Perlini, Marco Barillari, Amelia Versace, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
OBJECTIVES: Several magnetic resonance imaging (MRI) studies provided evidence of selective brain abnormalities in schizophrenia, both in cortical and subcortical structures. Basal ganglia are of particular interest, given not only the high concentration of dopaminergic neurons and receptors, but also for their crucial role in cognitive functions, commonly impaired in schizophrenia. To date, very few studies explored basal ganglia using diffusion imaging, which is sensitive to microstructural organization in brain tissues...
June 23, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28637279/high-dimensional-multivariate-mediation-with-application-to-neuroimaging-data
#3
Oliver Y Chén, Ciprian Crainiceanu, Elizabeth L Ogburn, Brian S Caffo, Tor D Wager, Martin A Lindquist
Mediation analysis is an important tool in the behavioral sciences for investigating the role of intermediate variables that lie in the path between a treatment and an outcome variable. The influence of the intermediate variable on the outcome is often explored using a linear structural equation model (LSEM), with model coefficients interpreted as possible effects. While there has been significant research on the topic, little work has been done when the intermediate variable (mediator) is a high-dimensional vector...
June 15, 2017: Biostatistics
https://www.readbyqxmd.com/read/28635194/volitional-rehabilitative-assessments-in-patients-admitted-in-a-post-intensive-care-step-down-unit-a-feasibility-study
#4
Mara Paneroni, Francesco D' Abrosca, Georges Fokom, Laura Comini, Michele Vitacca
A high variability in functional tests and activities used during the pulmonary rehabilitation has been observed in post-intensive care unit (ICU) patients, and the best battery of tests to adopt has not been described yet. We tested in patients admitted in a post-ICU Step Down Unit the ability to perform the more frequent functional volitional tests. The relations of each single volitional test with general disability and dyspnea at discharge were also evaluated. Ten volitional tests including: bedside spirometry test (ST: FEV1%, FVC%), maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), Peak Expiratory Flow during Cough (PCEF), Quadriceps Muscle Strength (QMS), latissimus Dorsi and teres Major Strength (DMS), Brachial biceps Muscle Strength (BMS), effort tolerance measured by sit-to-stand test, Takahashi test and 6-Min Walking Test (6MWT), were evaluated in post-ICU patients at entry and discharge from in-hospital rehabilitation...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28626978/a-fast-multi-target-inverse-treatment-planning-strategy-optimizing-dosimetric-measures-for-high-dose-rate-hdr-brachytherapy
#5
Christian V Guthier, Antonio L Damato, Akila N Viswanathan, Juergen W Hesser, Robert A Cormack
PURPOSE: In this study, we introduce a novel, fast, inverse treatment planning strategy for interstitial high-dose-rate (HDR) brachytherapy with multiple regions of interest solely based on dose-volume-histogram-related dosimetric measures (DMs). METHODS: We present a new problem formulation of the objective function that approximates the indicator variables of the standard DM optimization problem with a smooth logistic function. This problem is optimized by standard gradient-based methods...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28618662/a-one-year-on-line-multi-site-observational-study-on-water-soluble-inorganic-ions-in-pm2-5-over-the-pearl-river-delta-region-china
#6
Jian Liu, Dui Wu, Shaojia Fan, Xia Mao, Huizhong Chen
As the significant components of PM2.5, almost all of previous studies on water-soluble inorganic ions (WSIIs) have been limited by the use of single sampling station, short sampling times or low temporal resolution. This paper focuses on analysing one-year (2012) observations of WSIIs at a regional central (RCEN) site, a coastal urban (CURB) site and a coastal rural (CRUR) site in the Pearl River Delta region. On average, secondary inorganic aerosols (SIA) were the most abundant component and accounted for over 80% of the total WSIIs...
June 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28613874/distinguishing-cis-and-trans-isomers-in-intact-complex-lipids-using-electron-impact-excitation-of-ions-from-organics-eieio-mass-spectrometry
#7
Takashi Baba, J Larry Campbell, J C Yves Le Blanc, Paul R S Baker
We present a mass spectrometry-based method for the identification of cis and trans double bond isomers within intact complex lipid mixtures using Electron Impact Excitation of Ions from Organics (EIEIO) mass spectrometry. EIEIO involves irradiating singly charged lipid ions with electrons having kinetic energies of 5-16 eV. The resulting EIEIO spectra can be used to discern cis and trans double bond isomers by virtue of the differences in the fragmentation patterns at the carbon-carbon single bonds neighboring the double bonds...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28605624/the-application-of-chromatographic-breath-analysis-in-the-search-of-volatile-biomarkers-of-chronic-kidney-disease-and-coexisting-type-2-diabetes-mellitus
#8
B Grabowska-Polanowska, M Skowron, P Miarka, A Pietrzycka, I Śliwka
Chromatographic studies on breath composition are aimed at finding volatile markers useful for medical diagnostics or in screening investigations. Studies leading to the development of screening breath tests are especially important for the diagnostics of chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). The aim of the presented study was to confirm diagnostic usefulness of chosen volatile compounds detected in breath, which are suggested as potential biomarkers of renal dysfunction and diabetes...
June 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28604459/definitive-chemoradiotherapy-in-elderly-cervical-cancer-patients-a-multiinstitutional-analysis
#9
Ozan Cem Guler, Sezin Yuce Sari, Sumerya Duru Birgi, Melis Gultekin, Ferah Yildiz, Cem Onal
OBJECTIVE: The aim of the study was to investigate the prognostic factors for survival and treatment-related toxicities in older (≥65 years) cervical cancer patients treated with definitive chemoradiotherapy. In addition, we sought to compare the outcomes between the older elderly (≥75 years) and their younger old counterparts (age, 65-74 years). MATERIALS AND METHODS: We retrospectively reviewed medical records from 269 biopsy-proven nonmetastatic cervical cancer patients treated with external radiotherapy and intracavitary brachytherapy at the departments of radiation oncology in 2 different universities...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28602000/integrated-waste-load-allocation-for-river-water-pollution-control-under-uncertainty-a-case-study-of-tuojiang-river-china
#10
Jiuping Xu, Shuhua Hou, Liming Yao, Chaozhi Li
This paper presents a bi-level optimization waste load allocation programming model under a fuzzy random environment to assist integrated river pollution control. Taking account of the leader-follower decision-making in the water function zones framework, the proposed approach examines the decision making feedback relationships and conflict coordination between the river basin authority and the regional Environmental Protection Agency (EPA) based on the Stackelberg-Nash equilibrium strategy. In the pollution control system, the river basin authority, as the leader, allocates equitable emissions rights to different subareas, and the then subarea EPA, as the followers, reallocates the limited resources to various functional zones to minimize pollution costs...
June 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28598523/mechanistic-insight-into-acrylate-metabolism-and-detoxification-in-marine-dimethylsulfoniopropionate-catabolizing-bacteria
#11
Peng Wang, Hai-Yan Cao, Xiu-Lan Chen, Chun-Yang Li, Ping-Yi Li, Xi-Ying Zhang, Qi-Long Qin, Jonathan D Todd, Yu-Zhong Zhang
Dimethylsulfoniopropionate (DMSP) cleavage, yielding dimethyl sulfide (DMS) and acrylate, provides vital carbon sources to marine bacteria, is a key component of the global sulfur cycle and effects atmospheric chemistry and potentially climate. Acrylate and its metabolite acryloyl-CoA are toxic if allowed to accumulate within cells. Thus, organisms cleaving DMSP require effective systems for both the utilization and detoxification of acrylate. Here, we examine the mechanism of acrylate utilization and detoxification in Roseobacters...
June 9, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28588991/healthcare-use-and-expenditure-for-diabetes-in-bangladesh
#12
Sheikh Mohammed Shariful Islam, Andreas Lechner, Uta Ferrari, Michael Laxy, Jochen Seissler, Jonathan Brown, Louis W Niessen, Rolf Holle
BACKGROUND: Diabetes imposes a huge social and economic impact on nations. However, information on the costs of treating and managing diabetes in developing countries is limited. The aim of this study was to estimate healthcare use and expenditure for diabetes in Bangladesh. METHODS: We conducted a matched case-control study between January and July 2014 among 591 adults with diagnosed diabetes mellitus (DMs) and 591 age-matched, sex-matched and residence-matched persons without diabetes mellitus (non-DMs)...
January 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28586048/modeling-osteosarcoma-progression-by-measuring-the-connectivity-dynamics-using-an-inference-of-multiple-differential-modules-algorithm
#13
Bin Liu, Zhi Zhang, E-Nuo Dai, Jia-Xin Tian, Jiang-Ze Xin, Liang Xu
Understanding the dynamic changes in connectivity of molecular pathways is important for determining disease prognosis. Thus, the current study used an inference of multiple differential modules (iMDM) algorithm to identify the connectivity changes of sub‑network to predict the progression of osteosarcoma (OS) based on the microarray data of OS at four Huvos grades. Initially, multiple differential co‑expression networks (M‑DCNs) were constructed, and weight values were assigned for each edge, followed by detection of seed genes in M‑DCNs according to the topological properties...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28582672/work-zone-sign-design-for-increased-driver-compliance-and-worker-safety
#14
Md Mahmudur Rahman, Lesley Strawderman, Teena Garrison, Deborah Eakin, Carrick C Williams
Many studies have investigated the effect of dynamic message signs (DMS) on drivers' speed reduction and compliance in work zones, yet only a few studies have examined the design of sign content of DMS. The purpose of this study was to develop design standards for DMS to improve driver compliance and worker safety. This study investigated the impact of sign content, frame refresh rate, and sign placement on driver speed reduction, compliance, and eye movements. A total of 44 participants were recruited for this study...
June 2, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28580221/improving-the-resolution-of-kendrick-mass-defect-analysis-for-polymer-ions-with-fractional-base-units
#15
Thierry Fouquet, Hiroaki Sato
The concept of a fractional base unit for the Kendrick mass defect (KMD) analysis of polymer ions is introduced for the first time. A fraction of the ethylene oxide (EO) repeat unit (namely EO/8) has been used for the KMD analysis of a poly(ethylene oxide) and found to amplify the variations of KMD between monoisotopic and (13)C isotopes, producing an isotopically resolved KMD plot at full scale when the KMD plot computed with EO is fuzzy. The expansion of the KMD dimension using a fractional base unit has then been successfully used to unequivocally discriminate all the distributions from a blend of poly(ethylene oxide)s in a high resolution KMD plot calculated with EO/3 as base unit...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28576726/nicotine-induced-and-d1-receptor-dependent-dendritic-remodeling-in-a-subset-of-dorsolateral-striatum-medium-spiny-neurons
#16
Daniel G Ehlinger, Julian C Burke, Craig G McDonald, Robert F Smith, Hadley C Bergstrom
Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral striatal medium spiny neurons (MSNs) is well-documented. Whether MSN dendrites in the dorsal striatum undergo a similar pattern of nicotine-induced structural remodeling is unknown. A morphometric analysis of Golgi-stained MSNs in rat revealed a natural asymmetry in dendritic morphology across the mediolateral axis, with larger, more complex MSNs found in the dorsolateral striatum (DLS)...
May 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28573666/detection-of-desmoplastic-melanoma-with-dermoscopy-and-reflectance-confocal-microscopy
#17
N G Maher, A Solinas, R A Scolyer, S Puig, G Pellacani, P Guitera
BACKGROUND: Desmoplastic melanoma (DM) is frequently misdiagnosed clinically and often associated with melanoma in situ (MIS). OBJECTIVE: To improve the detection of DM using dermoscopy and reflectance confocal microscopy (RCM). METHODS: A descriptive analysis of DM dermoscopy features and a case-control study within a melanoma population for RCM feature evaluation, performed blindly, using data obtained between 2005 and 2015. After retrospectively identifying all DM cases with RCM data over the study period (n=16), a control group of non-DM melanoma patients with RCM data, in a ratio of at least 3:1, was selected...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28571190/the-study-of-different-clinical-pattern-of-diabetic-ketoacidosis-and-common-precipitating-events-and-independent-mortality-factors
#18
M G Mahesh, Rajendra Prasad Shivaswamy, Bj Subhash Chandra, Sajid Syed
INTRODUCTION: Diabetic Ketoacidosis (DKA) is an important cause of morbidity and mortality among diabetic patients in spite of major advances in the pathogenesis and more standardized diagnosis and treatment. AIM: To find out the different patterns of clinical presentations, common precipitating factors and independent mortality factors in DKA. MATERIALS AND METHODS: This study was conducted in a tertiary care hospital, Mysuru on 110 patients from November 2007 to October 2009...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569332/mixed-cu-i-au-i-coordination-polymers-as-reversible-turn-on-vapoluminescent-sensors-for-volatile-thioethers
#19
Bryton R Varju, Jeffrey S Ovens, Daniel B Leznoff
Vapour-phase thioethers play an important role in a wide number of fields, including plant biology, chemical weapon disposal, and brewing but few sensor materials are known. The emissive coordination polymer Cu1/2Au1/2CN does not react with vapour phase dimethyl sulphide (DMS) or diethyl sulphide (DES) despite the independent synthesis of emissive [Cu1/2Au1/2CN]2(DMS) and [Cu1/2Au1/2CN]2(DES) from their constituent components in solution. However, the doped Cu2/3Au1/3CN rapidly reacts in the solid state with both of these vapour phase thioethers reversibly, with a change in emission from 380/560 nm to 460 nm (DMS) or 420 nm (DES), illustrating that doping the inactive parent Cu1/2Au1/2CN with Cu(i) generates an active sensor material...
June 1, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28566754/stroke-triggers-nigrostriatal-plasticity-and-increases-alcohol-consumption-in-rats
#20
Cathy C Y Huang, Tengfei Ma, Emily A Roltsch Hellard, Xuehua Wang, Amutha Selvamani, Jiayi Lu, Farida Sohrabji, Jun Wang
Excessive alcohol consumption is a known risk factor for stroke, but the effect of stroke on alcohol intake is unknown. The dorsomedial striatum (DMS) and midbrain areas of the nigrostriatal circuit are critically associated to stroke and alcohol addiction. Here we sought to explore the influence of stroke on alcohol consumption and to uncover the underlying nigrostriatal mechanism. Rats were trained to consume alcohol using a two-bottle choice or operant self-administration procedure. Retrograde beads were infused into the DMS or midbrain to label specific neuronal types, and ischemic stroke was induced in the dorsolateral striatum (DLS)...
May 31, 2017: Scientific Reports
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