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https://www.readbyqxmd.com/read/28432653/analyzing-glycopeptide-isomers-by-combining-differential-mobility-spectrometry-with-electron-and-collision-based-tandem-mass-spectrometry
#1
J Larry Campbell, Takashi Baba, Chang Liu, Catherine S Lane, J C Yves Le Blanc, James W Hager
Differential mobility spectrometry (DMS) has been employed to separate isomeric species in several studies. Under the right conditions, factors such as separation voltage, temperature, the presence of chemical modifiers, and residence time can combine to provide unique signal channels for isomeric species. In this study, we examined a set of glycopeptide isomers, MUC5AC-3 and MUC5AC-13, which bear an N-acetyl-galactosamine (GalNAc) group on either threonine-3 or threonine-13. When analyzed as a mixture, the resulting MS and MS/MS spectra yield fragmentation patterns that cannot discern these convolved species...
April 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28430039/distractor-resistant-stm-is-supported-by-transient-changes-in-neural-stimulus-representations
#2
Jan Derrfuss, Matthias Ekman, Michael Hanke, Marc Tittgemeyer, Christian J Fiebach
Goal-directed behavior in a complex world requires the maintenance of goal-relevant information despite multiple sources of distraction. However, the brain mechanisms underlying distractor-resistant working or STM are not fully understood. Although early single-unit recordings in monkeys and fMRI studies in humans pointed to an involvement of lateral prefrontal cortices, more recent studies highlighted the importance of posterior cortices for the active maintenance of visual information also in the presence of distraction...
April 21, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28418991/effect-of-legal-status-on-the-early-treatment-outcomes-of-migrants-beginning-combined-antiretroviral-therapy-at-an-outpatient-clinic-in-milan-italy
#3
Anna Lisa Ridolfo, Letizia Oreni, Paolo Vassalini, Chiara Resnati, Giorgio Bozzi, Laura Milazzo, Spinello Antinori, Stefano Rusconi, Massimo Galli
OBJECTIVE: In a setting of free access to HIV care, we compared the early treatment outcomes of HIV-infected undocumented migrants (UMs), documented migrants (DMs) and Italian subjects. METHODS: The clinical data of 640 Italians and 245 migrants who started combined ART (cART) at an HIV clinic in Milan, Italy, were reviewed. The migrants were mainly Latin Americans (83 DMs and 56 UMs) or sub-Saharan Africans (52 DMs and 11 UMs), but a minority were of other origin (33 DMs and 10 UMs)...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28403330/dental-management-survey-brazil-dms-br-creation-and-validation-of-a-management-instrument
#4
Paola Sampaio Gonzales, Ismar Eduardo Martins, Maria Gabriela Haye Biazevic, Paulo Roberto da Silva, Edgard Michel-Crosato
Questionnaires for the assessment of knowledge and self-perception can be useful to diagnose what a dentist knows about management and administration. The aim of the present study was to create and validate the Dental Management Survey Brazil (DMS-BR) scale, based on meetings with experts in the field. After having elaborated the first version, 10 audits were performed in dental offices in order to produce the final version, which included nine dimensions: location, patient, finance, marketing, competition, quality, staff, career, and productivity...
April 10, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28403180/amplification-of-a-transgene-within-a-long-array-of-replication-origins-favors-higher-gene-expression-in-animal-cells
#5
Kiwamu Ohsaki, Yusuke Ohgaki, Noriaki Shimizu
Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment region (MAR) are spontaneously amplified in transfected cells, and generate extrachromosomal double minute (DM) or chromosomal homogeneously staining region (HSR). We previously isolated the shortest core IR (G5) required for gene amplification. In this study, we ligated the G5 DNA to create direct or inverted repeats, mixed the repeats with an expression plasmid, and transfected the mixture into human COLO 320DM or hamster CHO DG44 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28381808/dissolving-microneedles-as-skin-allergy-test-device
#6
Yukako Ito, Kengo Matsumoto, Noriyuki Osakama, Ryosuke Yoshioka, Shinji Kobuchi, Toshiyuki Sakaeda, Kanji Takada
The possibility of using dissolving microneedles (DMs) as a skin allergy test device was studied in rats. Poly-L-arginine was used as a model allergen. Dextran was used to prepare three kinds of DM array chips containing different doses of poly-L-arginine: 17.1±0.5 µg (low-dose DM), 42.2±0.8 µg (medium-dose DM), and 87.4±1.1 µg (high-dose DM); each 1.0 cm(2) chip contained 300 DMs. The mean lengths of the low-, medium-, and high-dose DM were 489±3, 485±3, and 492±1 µm and mean diameters of the base were 301±2, 299±1, and 299±2 µm, respectively...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28375310/wavefront-correction-by-a-low-cost-deformable-mirror-group-in-a-small-aperture-beam-fiber-laser
#7
Lei Huang, Chenlu Zhou, Xingkun Ma, Meng Yan, Junbiao Fan
A low-cost deformable mirror (DM) group for wavefront correction in a small-aperture-beam fiber laser is reported in this paper. The DM group consists of nine single-actuator DMs and could act as a "virtual" 9-actuator DM arranged in a 3×3 array. The equivalent distance between two adjacent actuators could reach as small as 3 mm, which can lead to a relatively high lateral resolution. Reflection mirrors in the DM group can be individually polished and high-damage-threshold coated. The unique manufacture flexibility will ensure the particularly low cost of the DM group...
March 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28374313/differential-mobility-spectrometry-for-improved-selectivity-in-hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-analysis-of-paralytic-shellfish-toxins
#8
Daniel G Beach
Paralytic shellfish toxins (PSTs) are neurotoxins produced by dinoflagellates and cyanobacteria that cause paralytic shellfish poisoning in humans. PST quantitation by LC-MS is challenging because of their high polarity, lability as gas-phase ions, and large number of potentially interfering analogues. Differential mobility spectrometry (DMS) has the potential to improve the performance of LC-MS methods for PSTs in terms of selectivity and limits of detection. This work describes a comprehensive investigation of the separation of 16 regulated PSTs by DMS and the development of highly selective LC-DMS-MS methods for PST quantitation...
April 3, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28366865/glucocorticoid-administration-into-the-dorsolateral-but-not-dorsomedial-striatum-accelerates-the-shift-from-a-spatial-toward-procedural-memory
#9
Cristina Siller-Pérez, Norma Serafín, Roberto A Prado-Alcalá, Benno Roozendaal, Gina L Quirarte
Glucocorticoid stress hormones are known to enhance the consolidation of hippocampus-dependent spatial and contextual memory. Recent findings indicate that glucocorticoids also enhance the consolidation of procedural memory that relies on the dorsal striatum. The dorsal striatum can be functionally subdivided into the dorsolateral striatum (DLS), which is primarily implicated in shaping procedural memories, and the dorsomedial striatum (DMS), which is engaged in spatial memory. Here, we investigated the hypothesis that posttraining glucocorticoid administration into the DLS promotes the formation of a procedural memory that will normally take place only with extensive training...
March 30, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28361870/associations-between-daily-affective-instability-and-connectomics-in-functional-subnetworks-in-remitted-patients-with-recurrent-major-depressive-disorder
#10
Michelle N Servaas, Harriëtte Riese, Remco J Renken, Marieke Wichers, Jojanneke A Bastiaansen, Caroline A Figueroa, Hanneke Geugies, Roel Jt Mocking, Linda Geerligs, Jan-BernardC Marsman, André Aleman, Aart H Schene, Robert A Schoevers, Henricus G Ruhé
Remitted patients with major depressive disorder (rMDD) often report more fluctuations in mood as residual symptomatology. It is unclear how this affective instability is associated with information processing related to the default mode (DMS), salience/reward (SRS) and fronto-parietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD). Sixty-two unipolar, drug-free rrMDD patients (⩾2 MDD-episodes) and 41 HC (HC) were recruited. We used Experience Sampling Methodology (ESM) to monitor mood/cognitions (10 times a day for 6 days) and calculated affective instability using the mean adjusted absolute successive difference...
March 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28355711/-determination-of-dimethyl-sulfate-in-the-air-of-workplace-by-gc-ms
#11
C M Zhou, B L Zhu, X J Li, J Wu, Y M Liu
Objective: To establish a method to detect the concentrations of dimethyl sulfate in the air of workplace by GC-MS. Methods: DMS in the air of workplace adsorpted by Silicone tube, then desorped by acetone, add 1.0 ml of acetone, shake 1 min, placed after 30 min, the desorption solution qualitative and quantitative determination by gas chromatography-mass. Results: The calibration curves were liner in the range of 0.1-200.0 μg/ml. The within-run and between-run precisions were 2.6%-4.7% and 4.0%-9.0% respectively...
February 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28345892/a-silver-specific-dnazyme-with-a-new-silver-aptamer-and-salt-promoted-activity
#12
Runjhun Saran, Kimberly Kleinke, Wenhu Zhou, Tianmeng Yu, Juewen Liu
Most RNA-cleaving DNAzymes require a metal ion to interact with the scissile phosphate for activity. Therefore, few unmodified DNAzymes work with thiophilic metals because of their low affinity for phosphate. Recently, an Ag(+)-specific Ag10c DNAzyme was reported via in vitro selection. Herein, Ag10c is characterized to rationalize the role of the strongly thiophilic Ag(+). Systematic mutation studies indicate that Ag10c is a highly conserved DNAzyme and its Ag(+) binding is unrelated to C-Ag(+)-C interaction...
March 31, 2017: Biochemistry
https://www.readbyqxmd.com/read/28320154/advances-in-assessing-myotonia-can-sensor-engineered-glove-have-a-role
#13
Simona Portaro, Margherita Russo, Antonino Naro, Alessia Bramanti, Placido Bramanti, Carmelo Rodolico, Rocco Salvatore Calabrò
Non-dystrophic (NDMs) and Dystrophic Myotonias (DMs) are diseases characterized by the presence of myotonia with or without muscle weakness. A standardized myotonia assessment is important to more objectively quantify the handgrip myotonia. We screened 10 patients affected by NDM and 10 patients with DM, using the sensor-engineered glove (SEG). The time required to perform a complete finger extension (grip myotonia time, GMT) at maximum velocity (MV) after maximum voluntary contraction (MVC) was evaluated through an ad hoc protocol including rest, exercise, and ice effects on handgrip myotonia...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28303968/sex-differences-in-dna-methylation-of-the-cord-blood-are-related-to-sex-bias-psychiatric-diseases
#14
Mariana Maschietto, Laura Caroline Bastos, Ana Carolina Tahira, Elen Pereira Bastos, Veronica Luiza Vale Euclydes, Alexandra Brentani, Günther Fink, Angelica de Baumont, Aloísio Felipe-Silva, Rossana Pulcineli Vieira Francisco, Gisele Gouveia, Sandra Josefina Ferraz Ellero Grisi, Ana Maria Ulhoa Escobar, Carlos Alberto Moreira-Filho, Guilherme Vanoni Polanczyk, Euripedes Constantino Miguel, Helena Brentani
Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and with appropriate weight at birth regarding their potential connection to psychiatric outcomes. Mothers were interviewed to gather information about environmental factors (gestational exposure) that could interfere with the methylation profiles in the newborns...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295771/analysis-of-17%C3%AE-estradiol-estriol-and-estrone-in-american-eel-anguilla-rostrata-tissue-samples-using-liquid-chromatography-coupled-to-electrospray-differential-ion-mobility-tandem-mass-spectrometry
#15
Alejandro Cohen, Neil W Ross, Paul M Smith, James P Fawcett
RATIONALE: 17β-Estradiol (E2), estrone (E1) and estriol (E3) are steroid hormones responsible for the regulation of the female reproductive system. Estradiol is planned to be used to feminize eels in aquaculture in order to improve their size and marketability. The residual levels of these hormones in fish tissue must be monitored to meet the requirements of food regulatory agencies. Few studies have studied these hormones on complex biological matrices such as fish tissue. METHODS: We developed a method to analyze E1, E2 and E3 in fish tissue using liquid chromatography in combination with differential ion mobility spectrometry (DMS) and tandem mass spectrometry (MS/MS)...
March 11, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28280776/assessing-physicochemical-properties-of-drug-molecules-via-microsolvation-measurements-with-differential-mobility-spectrometry
#16
Chang Liu, J C Yves Le Blanc, Bradley B Schneider, Jefry Shields, James J Federico, Hui Zhang, Justin G Stroh, Gregory W Kauffman, Daniel W Kung, Christian Ieritano, Evan Shepherdson, Mitch Verbuyst, Luke Melo, Moaraj Hasan, Dalia Naser, John S Janiszewski, W Scott Hopkins, J Larry Campbell
The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong local hydrogen bonding exists between the molecule and the solvent. One method that can probe the microsolvated states of charged molecules is differential mobility spectrometry (DMS), which rapidly interrogates an ion's transitions between a solvated and desolvated state in the gas phase (i...
February 22, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28270071/inhibitory-effects-of-novel-sphk2-inhibitors-on-migration-of-cancer-cells
#17
Deokho Jung, Junghyun Jung, Euiyeon Lee, Chang Soo Mok, Hyunjin Jeon, Chang Seo Park, Wonhee Jang, Youngeun Kwon
Cell migration is an essential process for survival and differentiation of mammalian cells. Numerous diseases are induced or influenced by inappropriate regulation of cell migration, which plays a key role in cancer cell metastasis. In fact, very few anti-metastasis drugs are available on the market. SphKs are enzymes that convert sphingosine to sphingosine-1- phosphate (S1P) and are known to control various cellular functions, including migration of cells. Among two human isozymes of SphK2, SphK2 is known to promote apoptosis, suppresses cell growth, and controls cell migration; in addition, the specific ablation of SphK2 activity was reported to inhibit cancer cell metastasis...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28261173/gut-microbial-diversity-assessment-of-indian-type-2-diabetics-reveals-alterations-in-eubacteria-archaea-and-eukaryotes
#18
Shrikant S Bhute, Mangesh V Suryavanshi, Suyog M Joshi, Chittaranjan S Yajnik, Yogesh S Shouche, Saroj S Ghaskadbi
Diabetes in India has distinct genetic, nutritional, developmental and socio-economic aspects; owing to the fact that changes in gut microbiota are associated with diabetes, we employed semiconductor-based sequencing to characterize gut microbiota of diabetic subjects from this region. We suggest consolidated dysbiosis of eubacterial, archaeal and eukaryotic components in the gut microbiota of newly diagnosed (New-DMs) and long-standing diabetic subjects (Known-DMs) compared to healthy subjects (NGTs). Increased abundance of phylum Firmicutes (p = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28260033/revealing-differential-modules-in-uveal-melanoma-by-analyzing-differential-networks
#19
Li Han, Cui Chen, Chang-Hui Liu, Min Zhang, Ling Liang
The aim of the present study was to investigate differential modules (DMs) between uveal melanoma (UM) and normal conditions by examining differential networks. Based on a gene expression profile collected from the ArrayExpress database, the inference of DMs involved three steps: The first step was construction of a differential co‑expression network (DCN); second, the module algorithm was adapted to identify the DMs presented in DCN; finally, the statistical significance of DMs were assessed based on the null score distribution of DMs generated using randomized networks...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28255662/psychometric-evaluation-of-the-muscle-appearance-satisfaction-scale-in-a-mexican-male-sample
#20
María Del Consuelo Escoto Ponce de León, Lilián Elizabeth Bosques-Brugada, Esteban Jaime Camacho Ruiz, Georgina Alvarez-Rayón, Karina Franco Paredes, Gabriela Rodríguez Hernández
PURPOSE: The purpose of this study was to determine whether the muscle appearance satisfaction scale (MASS) shows acceptable psychometric properties in Mexican bodybuilders. METHODS: A total of 258 Mexican male bodybuilders were recruited. Two self-report questionnaires, including the MASS and drive for muscularity scale (DMS), were administered. Six models of the latent structure of the MASS were evaluated, using confirmatory factor analysis with maximum likelihood, considering robust Satorra-Bentler correction to estimate the fit of the models to the data...
March 2, 2017: Eating and Weight Disorders: EWD
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