keyword
https://read.qxmd.com/read/38524116/exploring-the-application-and-challenges-of-fnirs-technology-in-early-detection-of-parkinson-s-disease
#21
JOURNAL ARTICLE
Pengsheng Hui, Yu Jiang, Jie Wang, Congxiao Wang, Yingqi Li, Boyan Fang, Hujun Wang, Yingpeng Wang, Shuyan Qie
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a critical gap in the early and non-invasive detection of PD. Current diagnostic methods are often invasive, expensive, or late in identifying the disease, leading to missed opportunities for early intervention. OBJECTIVE: The goal of this study is to explore the efficiency and accuracy of combining fNIRS technology with machine learning algorithms in diagnosing early-stage PD patients and to evaluate the feasibility of this approach in clinical practice...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38523613/using-the-gross-motor-function-measure-evolution-ratio-to-compare-different-dosage-of-hyperbaric-treatment-with-conventional-therapies-in-children-with-cerebral-palsy-could-it-end-the-controversy
#22
Pierre Marois, Guy Letellier, Mikaël Marois, Laurent Ballaz
UNLABELLED: The Gross Motor Function Measure is used in most studies measuring gross motor function in children with cerebral palsy. In many studies, including those evaluating the effect of hyperbaric treatment, the Gross Motor Function Measure variations were potentially misinterpreted because of the lack of control groups. The Gross Motor Function Measure Evolution Ratio (GMFMER) uses historical data from the Gross Motor Function Classification System curves and allows to re-analyze previous published studies which used the Gross Motor Function Measure by considering the natural expected evolution of the Gross Motor Function Measure...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38523598/vessel-specific-quantification-of-cerebral-venous-oxygenation-with-velocity-encoding-preparation-and-rapid-acquisition
#23
JOURNAL ARTICLE
Zixuan Lin, Dengrong Jiang, Yiwen Hong, Yi Zhang, Yi-Cheng Hsu, Hanzhang Lu, Dan Wu
PURPOSE: Non-invasive measurement of cerebral venous oxygenation (Yv ) is of critical importance in brain diseases. The present work proposed a fast method to quantify regional Yv map for both large and small veins. METHODS: A new sequence was developed, referred to as TRU-VERA (T2 relaxation under velocity encoding and rapid acquisition, which isolates blood spins from static tissue with velocity-encoding preparation, modulates the T2 weighting of venous signal with T2 -preparation and utilizes a bSSFP readout to achieve fast acquisition with high resolution...
March 25, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38523024/prospective-randomized-pilot-trial-on-the-effects-of-mild-hypercapnia-on-cerebral-oxygen-saturation-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#24
JOURNAL ARTICLE
Chanchal Bhandari, Hemang Gandhi, Anil Panwar, Maruti Haranal, Himani Pandya
OBJECTIVE AND DESIGN: A single-center prospective randomized controlled study was conducted to assess the effect of targeted mild hypercapnia (TMH) on cerebral oxygen saturation (rSO2 ) in patients undergoing off-pump coronary artery bypass grafting (CABG). SETTING AND PARTICIPANTS: A prospective randomized controlled study involving 100 patients undergoing off-pump CABG at U. N. Mehta Hospital, Ahmedabad, Gujarat, India. INTERVENTION: Patients were randomized to either the TMH (PaCO2 45-55 mmHg) or the targeted normocapnia (TN; PaCO2 35-45 mmHg) group, containing 50 patients in each group...
March 6, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38522639/fgf17-protects-cerebral-ischemia-reperfusion-induced-blood-brain-barrier-disruption-via-fgf-receptor-3-mediated-pi3k-akt-signaling-pathway
#25
JOURNAL ARTICLE
Wen-Ting Huang, Xiong-Jian Chen, Yu-Kai Lin, Jun-Feng Shi, Hong Li, Hao-Di Wu, Ruo-Lin Jiang, Shuai Chen, Xue Wang, Xian-Xi Tan, Ke-Yang Chen, Peng Wang
Maintaining blood-brain barrier (BBB) integrity is critical components of therapeutic approach for ischemic stroke. Fibroblast growth factor 17 (FGF17), a member of FGF8 superfamily, exhibits the strongest expression throughout the wall of all major arteries during development. However, its molecular action and potential protective role on brain endothelial cells after stroke remains unclear. Here, we observed reduced levels of FGF17 in the serum of patients with ischemic stroke, as well as in the brains of mice subjected to middle cerebral artery occlusion (MCAO) injury and oxygen-glucose deprivation/reoxygenation (OGD/R)-induced brain microvascular endothelial cells (bEnd...
March 22, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38522312/catalpol-attenuates-ischemic-stroke-by-promoting-neurogenesis-and-angiogenesis-via-the-sdf-1%C3%AE-cxcr4-pathway
#26
JOURNAL ARTICLE
Mei-Feng Zhang, Jing-Hui Wang, Si Sun, Yi-Tong Xu, Dong Wan, Shan Feng, Zhen Tian, Hui-Feng Zhu
BACKGROUND: Stroke is a leading cause of disability and death worldwide. Currently, there is a lack of clinically effective treatments for the brain damage following ischemic stroke. Catalpol is a bioactive compound derived from the traditional Chinese medicine Rehmannia glutinosa and shown to be protective in various neurological diseases. However, the potential roles of catalpol against ischemic stroke are still not completely clear. PURPOSE: This study aimed to further elucidate the protective effects of catalpol against ischemic stroke...
January 15, 2024: Phytomedicine
https://read.qxmd.com/read/38521629/first-characterization-of-tissue-oxygen-saturation-recovery-patterns-in-pediatric-cardiac-surgery-patients-undergoing-remote-ischemic-preconditioning-and-the-association-with-clinical-outcomes
#27
JOURNAL ARTICLE
Maria A Vélez-Esquivia, Santiago Pedroza, Richard Rivera, Juan Camayo-Zorrilla, Gustavo A Cruz-Suárez
OBJECTIVE: This study aimed to delineate the recovery patterns of regional oxygen saturation (SrO2 ) in pediatric cardiac surgery patients subjected to remote ischemic preconditioning (RIPC), utilizing near-infrared spectroscopy (NIRS) for quantification. It also sought to establish the correlation between these perfusion patterns and postoperative clinical outcomes. DESIGN: A prospective longitudinal observational study. SETTING: The study was conducted at (BLINDED FOR REVIEW), a high-complexity service provider institution in (BLINDED FOR REVIEW)...
March 2, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38520864/neuroprotective-effects-of-the-salidroside-derivative-shpl-49-via-the-bdnf-trkb-gap43-pathway-in-rats-with-cerebral-ischemia
#28
JOURNAL ARTICLE
Suxin You, Zhouyun Ma, Pei Zhang, Wenwen Xu, Changsen Zhan, Nina Sang, Jiazhen Xu, Feiyun Wang, Jiange Zhang
Ischemic stroke is a common intravascular disease and one of the leading causes of death and disability. The salidroside derivative SHPL-49, which we previously synthesized, significantly attenuates cerebral ischemic injury in a rat model of permanent middle cerebral artery occlusion. To explore the neuroprotective mechanism of SHPL-49, the effects of SHPL-49 on the expression levels of neurotrophic factors in neurons and microglia and the polarization of microglia were investigated in the present study. SHPL-49 activated the brain-derived neurotrophic factor (BDNF) pathway, decreased the number of degenerated neurons, and accelerated neurogenesis in rats with cerebral ischemia...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520834/kellerin-alleviates-cerebral-ischemic-injury-by-inhibiting-ferroptosis-via-targeting-akt-mediated-transcriptional-activation-of-nrf2
#29
JOURNAL ARTICLE
Yan Mi, Yongping Wang, Yeshu Liu, Wen Dang, Libin Xu, Shaowen Tan, Linge Liu, Gang Chen, Yueyang Liu, Ning Li, Yue Hou
BACKGROUND: Ischemic stroke (IS) is characterized as a detrimental cerebrovascular disease with high mortality and disability. Ferroptosis is a novel mechanism involved in neuronal death. There is a close connection between IS and ferroptosis, and inhibiting ferroptosis may provide an effective strategy for treating IS. Our previous investigations have discovered that kellerin, the active compound of Ferula sinkiangensis K. M. Shen, possesses the capability to shield against cerebral ischemia injury...
February 3, 2024: Phytomedicine
https://read.qxmd.com/read/38520727/neutrophil-targeting-platform-reduces-neutrophil-extracellular-traps-for-improved-traumatic-brain-injury-and-stroke-theranostics
#30
JOURNAL ARTICLE
Qingchun Mu, Kai Yao, Madiha Zahra Syeda, Jinlong Wan, Qian Cheng, Zhen You, Rui Sun, Yufei Zhang, Huamiao Zhang, Yuting Lu, Zhicheng Luo, Yang Li, Fuyao Liu, Huiping Liu, Xinyu Zou, Yanfen Zhu, Kesong Peng, Chunming Huang, Xiaoyuan Chen, Longguang Tang
Traumatic brain injuries (TBI) and stroke are major causes of morbidity and mortality in both developing and developed countries. The complex and heterogeneous pathophysiology of TBI and cerebral ischemia-reperfusion injury (CIRI), in addition to the blood-brain barrier (BBB) resistance, is a major barrier to the advancement of diagnostics and therapeutics. Clinical data showed that the severity of TBI and stroke is positively correlated with the number of neutrophils in peripheral blood and brain injury sites...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38520370/brain-based-sex-differences-in-schizophrenia-a-systematic-review-of-fmri-studies
#31
REVIEW
Mohammad Amin Salehi, Rasa Zafari, Soheil Mohammadi, Mohammad Shahrabi Farahani, Mahsa Dolatshahi, Hamid Harandi, Amirhossein Poopak, Stephen R Dager
Schizophrenia is a chronic psychiatric disorder with characteristic symptoms of delusions, hallucinations, lack of motivation, and paucity of thought. Recent evidence suggests that the symptoms of schizophrenia, negative symptoms in particular, vary widely between the sexes and that symptom onset is earlier in males. A better understanding of sex-based differences in functional magnetic resonance imaging (fMRI) studies of schizophrenia may provide a key to understanding sex-based symptom differences. This study aimed to summarize sex-based functional magnetic resonance imaging (fMRI) differences in brain activity of patients with schizophrenia...
April 2024: Human Brain Mapping
https://read.qxmd.com/read/38517781/adipokine-vaspin-maintains-angiogenesis-and-neurological-function-during-cerebral-ischemia-reperfusion-via-suppressing-endoplasmic-reticulum-stress
#32
JOURNAL ARTICLE
Wentao Yan, Xiuhua He, Guanjun Wang, Guochao Hu, Bin Cui
INTRODUCTION: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine. It has been reported that decreased serum vaspin levels are significantly associated with stroke severity and prognosis. PURPOSE: This article aims to explore the theoretical feasibility of vaspin supplementation for cerebral ischemia-reperfusion (I/R) injury. METHODS: The I/R mouse models were constructed by the middle cerebral artery occlusion (MCAO) method, and the effects of vaspin on cerebral infarction, neurological function, angiogenesis and endoplasmic reticulum (ER) stress were explored...
March 21, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38517178/quantification-of-mediation-effects-of-white-matter-functional-characteristics-on-cognitive-decline-in-aging
#33
JOURNAL ARTICLE
Muwei Li, Kurt G Schilling, Fei Gao, Lyuan Xu, Soyoung Choi, Yurui Gao, Zhongliang Zu, Adam W Anderson, Zhaohua Ding, Bennett A Landman, John C Gore
Cognitive decline with aging involves multifactorial processes, including changes in brain structure and function. This study focuses on the role of white matter functional characteristics, as reflected in blood oxygenation level-dependent signals, in age-related cognitive deterioration. Building on previous research confirming the reproducibility and age-dependence of blood oxygenation level-dependent signals acquired via functional magnetic resonance imaging, we here employ mediation analysis to test if aging affects cognition through white matter blood oxygenation level-dependent signal changes, impacting various cognitive domains and specific white matter regions...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38515139/hypochlorous-acid-derived-from-microglial-myeloperoxidase-could-mediate-high-mobility-group-box-1-release-from-neurons-to-amplify-brain-damage-in-cerebral-ischemia-reperfusion-injury
#34
JOURNAL ARTICLE
Shuang Chen, Jingrui Pan, Zhe Gong, Meiling Wu, Xiaoni Zhang, Hansen Chen, Dan Yang, Suhua Qi, Ying Peng, Jiangang Shen
Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia-reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility group box 1 (HMGB1) oxidation, particularly disulfide HMGB1 formation, facilitates the secretion and release of HMGB1 and activates neuroinflammation, aggravating cerebral I/R injury. However, the cellular sources of MPO/HOCl in ischemic brain injury are unclear yet. Whether HOCl could promote HMGB1 secretion and release remains unknown...
March 21, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38513574/mechanism-of-astragaloside-iv-regulating-nlrp3-through-loc102555978-to-attenuate-cerebral-ischemia-reperfusion-induced-microglia-pyroptosis
#35
JOURNAL ARTICLE
Ping Gao, Haowei Shi, Xiaofei Jin, Shuhan Guo, Xiaohong Zhou, Weijuan Gao
Astragaloside IV(ASⅣ), the main component of Radix Astragali, has been used to treat cerebral ischemia reperfusion injury (CIRI). However, the molecular mechanism of ASIV in CIRI needs to be further elucidated. Long non-coding RNA (lncRNA) is considered to be an important kind of regulatory molecule in CIRI. In this work, the biological effect and molecular mechanism of ASIV in CIRI through lncRNA were analyzed by using rat middle cerebral artery occlusion and reperfusion (MCAO/R) model and primary rat microglia (RM) cells oxygen and glucose deprivation/reoxygenation (OGD/R) model...
March 20, 2024: International Immunopharmacology
https://read.qxmd.com/read/38513376/n-cinnamoylpyrrole-derived-alkaloids-from-the-genus-piper-as-promising-agents-for-ischemic-stroke-by-targeting-eef1a1
#36
JOURNAL ARTICLE
Baojun Su, Gaowu Huang, Shanshan Zhu, Yaqi Wang, Qian Lan, Yue Hou, Dong Liang
BACKGROUND: Ischemic stroke (IS) is a serious cerebrovascular disease characterized by significantly elevated mortality and disability rates, and the treatments available for this disease are limited. Neuroinflammation and oxidative stress are deemed the major causes of cerebral ischemic injury. N-Cinnamoylpyrrole alkaloids form a small group of natural products from the genus Piper and have not been extensively analyzed pharmacologically. Thus, identifying the effect and mechanism of N-cinnamoylpyrrole-derived alkaloids on IS is worthwhile...
February 14, 2024: Phytomedicine
https://read.qxmd.com/read/38513137/cpeb4-mediated-dclk2-promotes-neuronal-pyroptosis-induced-by-chronic-cerebral-ischemia-through-phosphorylation-of-ehf
#37
JOURNAL ARTICLE
Miao Sun, Xin Huang, Xuelei Ruan, Xiuli Shang, Mengyang Zhang, Libo Liu, Ping Wang, Ping An, Yang Lin, Jin Yang, Yixue Xue
Chronic cerebral ischemia (CCI) is a clinical syndrome characterised by brain dysfunction due to decreased chronic cerebral perfusion. CCI initiates several inflammatory pathways, including pyroptosis. RNA-binding proteins (RBPs) play important roles in CCI. This study aimed to explore whether the interaction between RBP-Cpeb4 and Dclk2 affected Ehf phosphorylation to regulate neuronal pyroptosis. HT22 cells and mice were used to construct oxygen glucose deprivation (OGD)/CCI models. We found that Cpeb4 and Dclk2 were upregulated in OGD-treated HT22 cells and CCI-induced hippocampal CA1 tissues...
March 21, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38511170/early-exercise-intervention-promotes-myelin-repair-in-the-brains-of-ischemic-rats-by-inhibiting-the-mek-erk-pathway
#38
JOURNAL ARTICLE
Junyi Wang, Xinyu Ding, Chen Li, Chuan Huang, Changkai Ke, Chunlei Xu, Chunxiao Wan
Our previous studies have shown that early exercise intervention after stroke increases neural activity and synaptic plasticity and promotes the recovery of nerve fiber bundle integrity in the brain. However, the effect of exercise on the repair of myelin in the brain and the related mechanism are still unclear. In this study, we randomly divided the rats into three groups. Before and after 28 days of intervention, body weight, nerve function, the infarct size, white matter fiber bundle integrity, and nerve myelin structure and function were observed by measuring body weight, analysis of modified neurological severity score, CatWalk gait analysis, MRI, luxol fast blue staining, immunofluorescence, and transmission electron microscopy...
January 1, 2024: Translational Neuroscience
https://read.qxmd.com/read/38510614/changes-in-autonomic-function-and-cerebral-and-somatic-oxygenation-with-arterial-flow-pulsatility-for-children-requiring-veno-arterial-extracorporeal-membrane-oxygenation
#39
JOURNAL ARTICLE
Brian Appavu, Elise Dunning, Kara Hildebrandt, Damla Hanalioglu, Todd Abruzzo
BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) carries variability in arterial flow pulsatility (AFP). RESEARCH QUESTION: What changes in cerebral and somatic oxygenation, hemodynamics, and autonomic function are associated with AFP during VA-ECMO? METHODS: This is a prospective study of children on VA-ECMO undergoing neuromonitoring. AFP was quantified by arterial blood pressure pulse amplitude and subcategorized: no pulsatility (<1 mmHg), minimal pulsatility (1 to <5 mmHg), moderate pulsatility (5 to <15 mmHg) and high pulsatility (≥15 mmHg)...
2024: Brain Spine
https://read.qxmd.com/read/38510604/red-solid-line-patterns-of-terminal-loss-of-cerebrovascular-reactivity-at-the-bedside
#40
JOURNAL ARTICLE
Erta Beqiri, Marek Czosnyka, Michal M Placek, Giada Cucciolini, Virginia Motroni, Claudia A Smith, Peter Hutchinson, Peter Smielewski
INTRODUCTION: Continuous monitoring of the pressure reactivity index (PRx) provides an estimation of dynamic cerebral autoregulation (CA) at the bedside in traumatic brain injury (TBI) patients. Visualising the time-trend of PRx with a risk bar chart in ICM + software at the bedside allows for better real-time interpretability of the autoregulation status. When PRx>0.3 is sustained for long periods, typically of at least half an hour, the bar shows a pattern called "red solid line" (RSL)...
2024: Brain Spine
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