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Cerebral oxygenation

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https://www.readbyqxmd.com/read/29242570/monitoring-cerebral-oxygenation-of-preterm-infants-using-a-neonatal-specific-sensor
#1
M Kenosi, J M O'Toole, G A Hawkes, W Hutch, E Low, M Wall, G B Boylan, C A Ryan, E M Dempsey
INTRODUCTION: Cerebral oxygenation (rcSO2) monitoring in preterm infants may identify periods of cerebral hypoxia or hyperoxia. We hypothesised that there was a relationship between rcSO2 values and short term outcome in infants of GA < 32weeks. METHODS: RcSO2 values were recorded for the first 48 h of life using an INVOS monitor with a neonatal sensor. The association between cranial ultrasound scan measured brain injury and rcSO2 was assessed. RESULTS: 120 infants were included...
December 15, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29238467/neuroprotection-of-a-sesamin-derivative-1-2-bis-3-methoxyphenyl-methyl-ethane-1-2-dicaroxylic-acid-mmeda-against-ischemic-and-hypoxic-neuronal-injury
#2
Chang-Tsen Hung, Li-Dian Chen, Chien-Wei Hou
Objectives: Stroke may cause severe neuronal damage. The sesamin have been demonstrated to possess neuroprotection by its antioxidant and anti-inflammatory properties. One sesamin derivative was artificially composited, 1, 2-bis [(3-methoxyphenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) had been developed to study its antioxidative activity and neuroprotection. Materials and Methods: The infaction of Sprague Dawley (SD) rats and hypoxia models of BV-2 microglia or PC12 cells were investigated for in vivo and in vitro test respectively...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238035/long-non-coding-rna-meg3-functions-as-a-competing-endogenous-rna-to-regulate-ischemic-neuronal-death-by-targeting-mir-21-pdcd4-signaling-pathway
#3
Honglin Yan, Jie Rao, Jingping Yuan, Likun Gao, Wenxian Huang, Lina Zhao, Jiacai Ren
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been demonstrated as an important regulator in diverse human cancers. However, its function and regulatory mechanism in ischemic stroke remains largely unknown. Here, we report that MEG3 is physically associated with microRNA-21 (miR-21), while miR-21 is downregulated following ischemia in the ischemic core in vitro and in vivo, which is opposite to MEG3. Besides, overexpression of miR-21 protects oxygen-glucose deprivation and reoxygenation (OGD/R)-induced apoptotic cell death...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29236326/knockdown-of-ski-decreased-the-reactive-astrocytes-proliferation-in-vitro-induced-by-oxygen-glucose-deprivation-reoxygenation
#4
Xin Zhao, Kai-Sheng Zhou, Zhong-Hao Li, Wei Nan, Jing Wang, Ya-Yi Xia, Hai-Hong Zhang
Glia scar is a pathological marker in late phase of brain ischemia disease, which constitutes a major physical biochemical barrier to impede axonal regrowth. Astrocytes are known to be critically involved in the formation of glial scar. However, their response to ischemia and their role in neuroprotection after central nervous system (CNS) injury are not completely clear. Recently, we have demonstrated for the first time that Ski was up-regulated in reactive astrocytes after spinal cord injury in vivo and in vitro, which indicates Ski may be a new molecule that control astrocytes biologic properties after CNS injury...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29230624/an-observational-study-of-the-optimal-placement-of-a-cerebral-oximeter-probe-to-avoid-the-frontal-sinus-in-children
#5
Eun-Hee Kim, Kyu-Young Song, In-Kyung Song, Ji-Hyun Lee, Young-Eun Jang, Hee-Soo Kim, Seo-Hee Lee, Jin-Tae Kim
The frontal sinus is an airspace behind the brow ridge in the skull and can affect the accuracy of the regional cerebral oxygen saturation measurements. We evaluated the optimal location for placement of a cerebral oximeter probe while avoiding the frontal sinus in pediatric patients. This retrospective observational study included 203 pediatric patients aged 3-17 years who had undergone brain computed tomography from November 2010 to December 2015. The patients were divided into five subgroups based on their age...
December 11, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29229261/preliminary-experience-in-combined-somatic-and-cerebral-oximetry-monitoring-in-liver-transplantation
#6
Tina Hu, Yves Collin, Réal Lapointe, François Martin Carrier, Luc Massicotte, Annik Fortier, Jean Lambert, Franck Vandenbroucke-Menu, André Y Denault
OBJECTIVE: The use of cerebral near-infrared spectroscopy (NIRS) has become widespread in cardiac surgery after research demonstrated an association between perioperative cerebral desaturations and postoperative complications. Somatic NIRS desaturation also is associated with an increased risk of postoperative complications and mortality. The objective of this study was to explore the trends of both somatic and cerebral NIRS during liver transplantation. DESIGN: A prospective, single-site, observational case series...
July 20, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29229052/functional-magnetic-resonance-imaging-of-cerebral-hemodynamic-responses-to-pain-following-thoracic-thrust-manipulation-in-individuals-with-neck-pain-a-randomized-trial
#7
Cheryl L Sparks, Wen C Liu, Joshua A Cleland, Joseph P Kelly, Sarah J Dyer, Kathryn M Szetela, James M Elliott
OBJECTIVE: The purpose of this study was to examine whether cerebral activation in response to noxious mechanical stimuli varies with thrust manipulation (TM) when compared with sham manipulation (SM) as measured by blood oxygenation level-dependent functional magnetic resonance imaging. METHODS: Twenty-four volunteers (67% female) with complaints of acute or subacute mechanical (nontraumatic) neck pain satisfied eligibility requirements and agreed to participate...
November 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29228630/transplantation-of-ips-cell-derived-neural-progenitors-overexpressing-sdf-1%C3%AE-increases-regeneration-and-functional-recovery-after-ischemic-stroke
#8
Monica Chau, Todd C Deveau, Mingke Song, Zheng Z Wei, Xiaohuan Gu, Shan Ping Yu, Ling Wei
Ischemic stroke is a leading cause of human death and disability while clinical treatments are limited. The adult brain possesses endogenous regenerative activities that may benefit tissue repair after stroke. Trophic factors such as stromal cell-derived factor 1 alpha (SDF-1α) are upregulated in the ischemic brain, which promote endogenous regeneration. The regenerative response, however, is normally insufficient. Transplantation of exogenous cells has been explored as regenerative therapies. One promising cell type for transplantation is induced pluripotent stem (iPS) cells which are cells genetically reprogrammed from adult somatic cells...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228445/the-protective-effect-and-its-mechanism-of-3-n-butylphthalide-pretreatment-on-cerebral-ischemia-reperfusion-injury-in-rats
#9
R-Y Yan, S-J Wang, G-T Yao, Z-G Liu, N Xiao
OBJECTIVE: To investigate the potential effect of 3-n-butylphthalide (NBP) pretreatment on the cerebral ischemia/reperfusion injury in rats and the relevant mechanism. MATERIALS AND METHODS: A total of 90 rats was divided into three groups: Sham operation group (Sham group), ischemia-reperfusion group (I-R group), and NBP pretreatment group (NBP group 75 mg·kg-1·d-1 gavage). Pre-treatment was given once a day within 1 week before establishing the rat model of cerebral ischemia-reperfusion injury...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29225149/detection-and-characterization-of-molecular-level-collagen-damage-in-overstretched-cerebral-arteries
#10
Matthew I Converse, Raymond G Walther, Justin T Ingram, Yang Li, S Michael Yu, Kenneth L Monson
It is well established that overstretch of arteries alters their mechanics and compromises their function. However, the underlying structural mechanisms behind these changes are poorly understood. Utilizing a recently developed collagen hybridizing peptide (CHP), we demonstrate that a single mechanical overstretch of an artery produces molecular-level unfolding of collagen. In addition, imaging and quantification of CHP binding revealed that overstretch produces damage (unfolding) among fibers aligned with the direction of loading, that damage increases with overstretch severity, and that the onset of this damage is closely associated with tissue yielding...
December 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29224727/high-resolution-cbv-fmri-allows-mapping-of-laminar-activity-and-connectivity-of-cortical-input-and-output-in-human-m1
#11
Laurentius Huber, Daniel A Handwerker, David C Jangraw, Gang Chen, Andrew Hall, Carsten Stüber, Javier Gonzalez-Castillo, Dimo Ivanov, Sean Marrett, Maria Guidi, Jozien Goense, Benedikt A Poser, Peter A Bandettini
Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers. However, it is unknown to what level human fMRI is specific and sensitive enough to reveal directional functional activity across layers. To answer this question, we developed acquisition and analysis methods for blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-based laminar fMRI and used these to discriminate four different tasks in the human motor cortex (M1)...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29219760/direct-visualization-of-microcirculation-impairment-after-acute-subdural-hemorrhage-in-a-novel-animal-model
#12
Huan-Chih Wang, Jui-Chang Tsai, Jing-Er Lee, Sheng-Jean Huang, Abel Po-Hao Huang, Wei-Chou Lin, Sung-Tsang Hsieh, Kuo-Chuan Wang
OBJECTIVE Direct brain compression and secondary injury due to increased intracranial pressure are believed to be the pathognomic causes of a grave outcome in acute subdural hemorrhage (aSDH). However, ischemic damage from aSDH has received limited attention. The authors hypothesized that cerebral microcirculation is altered after aSDH. Direct visualization of microcirculation was conducted in a novel rat model. METHODS A craniectomy was performed on each of the 18 experimental adult Wistar rats, followed by superfusion of autologous arterial blood onto the cortical surface...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29218511/optical-monitoring-of-cerebral-microcirculation-in-neurointensive-care
#13
Peter Rejmstad, Neda Haj-Hosseini, Oscar Åneman, Karin Wårdell
Continuous optical monitoring of local cerebral microcirculation could benefit neurointensive care patients treated for subarachnoid hemorrhage (SAH). The aim of the study was to evaluate laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) for long-term monitoring of brain microcirculation and oxygen saturation (SO2) in the neurointensive care unit (NICU). A fiber optic probe was designed for intraparenchymal use and connected to LDF and DRS for assessment of the local blood flow (perfusion and tissue reflectance (TLI)) and SO2 in the brain...
December 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29218007/alteration-of-venous-drainage-route-in-idiopathic-normal-pressure-hydrocephalus-and-normal-aging
#14
Takeshi Satow, Toshihiko Aso, Sei Nishida, Taro Komuro, Tsukasa Ueno, Naoya Oishi, Yukako Nakagami, Masashi Odagiri, Takayuki Kikuchi, Kazumichi Yoshida, Keita Ueda, Takeharu Kunieda, Toshiya Murai, Susumu Miyamoto, Hidenao Fukuyama
Idiopathic normal pressure hydrocephalus (iNPH) is a highly prevalent condition in the elderly population; however, the underlying pathophysiology in relation to the aging process remains unclear. To investigate the effect of removal of cerebrospinal fluid by lumbar "tap test" on the cerebral circulation in patients with iNPH, 14 patients with "probable" iNPH were studied using a novel blood tracking technique based on blood oxygenation level-dependent (BOLD) magnetic resonance signal intensity. By tracking the propagation of the low-frequency component of the BOLD signal, extended venous drainage times were observed in the periventricular region of the patients, which was reversed by tap test...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29217405/a-novel-perspective-to-calibrate-temporal-delays-in-cerebrovascular-reactivity-using-hypercapnic-and-hyperoxic-respiratory-challenges
#15
Allen A Champagne, Alex A Bhogal, Nicole S Coverdale, Clarisse I Mark, Douglas J Cook
Redistribution of blood flow across different brain regions, arising from the vasoactive nature of hypercapnia, can introduce errors when examining cerebrovascular reactivity (CVR) response delays. In this study, we propose a novel analysis method to characterize hemodynamic delays in the blood oxygen level dependent (BOLD) response to hypercapnia, and hyperoxia, as a way to provide insight into transient differences in vascular reactivity between cortical regions, and across tissue depths. A pseudo-continuous arterial spin labeling sequence was used to acquire BOLD and cerebral blood flow simultaneously in 19 healthy adults (12 F; 20 ± 2 years) during boxcar CO2 and O2 gas inhalation paradigms...
December 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29215305/cerebrovascular-function-and-mitochondrial-bioenergetics-after-ischemia-reperfusion-in-male-rats
#16
Ibolya Rutkai, Ivan Merdzo, Sanjay V Wunnava, Genevieve T Curtin, Prasad Vg Katakam, David W Busija
The underlying factors promoting increased mitochondrial proteins, mtDNA, and dilation to mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal was to determine the morphological and functional effects of ischemia/reperfusion (I/R) on mitochondria using electron microscopy, Western blot, mitochondrial oxygen consumption rate (OCR), and Ca2+ sparks activity measurements in middle cerebral arteries (MCAs) from male Sprague Dawley rats (Naïve, tMCAO, Sham). We found a greatly increased OCR in ipsilateral MCAs (IPSI) compared with contralateral (CONTRA), Sham, and Naïve MCAs...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29212737/astrocytic-lrp4-low-density-lipoprotein-receptor-related-protein-4-contributes-to-ischemia-induced-brain-injury-by-regulating-atp-release-and-adenosine-a2ar-adenosine-a2a-receptor-signaling
#17
Xin-Chun Ye, Jin-Xia Hu, Lei Li, Qiang Li, Fu-Lei Tang, Sen Lin, Dong Sun, Xiang-Dong Sun, Gui-Yun Cui, Lin Mei, Wen-Cheng Xiong
BACKGROUND AND PURPOSE: Lrp4 (low-density lipoprotein receptor-related protein 4) is predominantly expressed in astrocytes, where it regulates glutamatergic neurotransmission by suppressing ATP release. Here, we investigated Lrp4's function in ischemia/stroke-induced brain injury response, which includes glutamate-induced neuronal death and reactive astrogliosis. METHODS: The brain-specific Lrp4 conditional knockout mice (Lrp4GFAP-Cre), astrocytic-specific Lrp4 conditional knockout mice (Lrp4GFAP-creER), and their control mice (Lrp4f/f) were subjected to photothrombotic ischemia and the transient middle cerebral artery occlusion...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212172/safflor-yellow-b-reduces-hypoxia-mediated-vasoconstriction-by-regulating-endothelial-micro-ribonucleic-acid-nitric-oxide-synthase-signaling
#18
Chaoyun Wang, Ying Yang, Miao Li, Xin Liu, Qiaoyun Wang, Wenyu Xin, Hongliu Sun, Qingyin Zheng
Hypoxia-induced generation of vasoconstrictors reduces cerebral blood flow (CBF) while nitric oxide (NO) synthase (NOS) and microRNAs (miRNA) in endothelial cells (ECs) suppress vasoconstriction. Safflor yellow B (SYB), a natural plant compound, previously attenuated angiotensin II-mediated injury of ECs and maintained endothelial function. This study investigated the putative involvement of NOS and miRNAs in SYB-mediated resistance to hypoxia-induced vasoconstriction. In vivo, chronic hypoxia was induced in rats, and SYB was administered intravenously...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211056/krebs-cycle-metabolites-and-preferential-succinate-oxidation-following-neonatal-hypoxic-ischemic-brain-injury-in-mice
#19
Prateek V Sahni, Jimmy Zhang, Sergey Sosunov, Alexander Galkin, Zoya Niatsetskaya, Anatoly Starkov, Paul S Brookes, Vadim S Ten
BackgroundReverse electron transport (RET) driven by the oxidation of succinate has been proposed as the mechanism of accelerated production of reactive oxygen species (ROS) in post-ischemic mitochondria. However, it remains unclear whether upon reperfusion, mitochondria preferentially oxidase succinate.MethodsNeonatal mice were subjected to Rice-Vannucci model of hypoxic-ischemic brain injury (HI) followed by assessment of Krebs cycle metabolites, mitochondrial substrate preference, and H2O2 generation rate in the ischemic brain...
December 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29210291/use-of-cerebral-oxygen-saturation-and-hemoglobin-concentration-to-predict-acute-kidney-injury-after-cardiac-surgery
#20
Canan Balci, Engin Haftaci, Atike Tekeli Kunt
Objective Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with significant morbidity and mortality. Near infrared spectroscopy (NIRS) is a noninvasive technique for real-time measurement of cerebral tissue oxygenation. The purpose of the present study was to evaluate the correlation of AKI with hemoglobin and regional cerebral oxygen saturation (rScO2) measured intraoperatively and postoperatively in patients undergoing cardiac surgery. Methods We retrospectively analyzed the prospectively collected data of 45 adult patients with normal renal function who underwent isolated coronary artery bypass grafting (CABG) from January 2014 to May 2014...
January 1, 2017: Journal of International Medical Research
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