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https://www.readbyqxmd.com/read/28102864/transthyretin-v122i-pv142i-cardiac-amyloidosis-an-age-dependent-autosomal-dominant-cardiomyopathy-too-common-to-be-overlooked-as-a-cause-of-significant-heart-disease-in-elderly-african-americans
#1
REVIEW
Joel N Buxbaum, Frederick L Ruberg
Since the identification of a valine-to-isoleucine substitution at position 122 (TTR V122I; pV142I) in the transthyretin (TTR)-derived fibrils extracted from the heart of a patient with late-onset cardiac amyloidosis, it has become clear that the amyloidogenic mutation and the disease occur almost exclusively in individuals of identifiable African descent. In the United States, the amyloidogenic allele frequency is 0.0173 and is carried by 3.5% of community-dwelling African Americans. Genotyping across Africa indicates that the origin of the allele is in the West African countries that were the major source of the slave trade to North America...
January 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28099659/factors-associated-with-the-use-of-antihypertensives-among-seniors
#2
Kaio Henrique Correa Massa, José Leopoldo Ferreira Antunes, Maria Lúcia Lebrão, Yeda Aparecida Oliveira Duarte, Alexandre Dias Porto Chiavegatto
OBJECTIVE: Analyze the use of antihypertensives among seniors and the association with socioeconomic and behavioral characteristics. METHODS: In this seriate cross-sectional study, we used data from the Saúde, Bem Estar e Envelhecimento study (SABE - Health, Well-being, and Aging), conducted in 2000, 2006, and 2010 in the city of São Paulo. Association between the use of antihypertensives and the demographic, behavioral, and socioeconomic characteristics and risk factors was analyzed by using multilevel logistic regression models...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099324/interaction-of-isoflurane-tumor-necrosis-factor-%C3%AE-and-%C3%AE-amyloid-on-long-term-potentiation-in-rat-hippocampal-slices
#3
Ran Zhou, Philip Bickler
BACKGROUND: The relationship between inhalational anesthetics such as isoflurane and cognitive impairment in the elderly is controversial. Both β-amyloid peptide (Aβ), associated with Alzheimer disease, and tumor necrosis factor-α (TNF-α), a proinflammatory stress-related peptide, impair the synaptic function. We hypothesized that transient exposure to isoflurane and these peptides would impair synaptic function, manifest as a depression of long-term potentiation (LTP) and paired pulse facilitation (PPF), in the rat hippocampus...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28089414/acupressure-effect-on-sleep-quality-a-systematic-review-and-meta-analysis
#4
REVIEW
Alexander Waits, You-Ren Tang, Hao-Min Cheng, Chen-Jei Tai, Li-Yin Chien
Acupressure is a non-invasive treatment in which pressure is applied to specific body points. Following public health concerns about poor sleep quality and increasing interest in alternative treatments, a systematic review and a meta-analysis were designed to evaluate the effects of acupressure on the quality of sleep. Ten English (PubMed, CENTRAL, CINAHL etc.) and five Chinese (CNKI, WANFANG etc.) databases were searched and the validity of the eligible studies was critically appraised. Thirty-two eligible randomized controlled trials of moderate to high quality which employed polysomnography, actigraphy, or self-assessment sleep quality tools were included...
December 22, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28086924/treating-infants-with-frigg-linking-disease-aetiologies-medicinal-plant-use-and-care-seeking-behaviour-in-southern-morocco
#5
Irene Teixidor-Toneu, Gary J Martin, Rajindra K Puri, Ahmed Ouhammou, Julie A Hawkins
BACKGROUND: Although most Moroccans rely to some extent on traditional medicine, the practice of frigg to treat paediatric ailments by elderly women traditional healers known as ferraggat, has not yet been documented. We describe the role of these specialist healers, document the medicinal plants they use, and evaluate how and why their practice is changing. METHODS: Ethnomedicinal and ethnobotanical data were collected using semi-structured interviews and observations of medical encounters...
January 13, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28078243/ethnobotanical-knowledge-of-apiaceae-family-in-iran-a-review
#6
REVIEW
Mohammad Sadegh Amiri, Mohammad Reza Joharchi
OBJECTIVE: Apiaceae (Umbelliferae) family is one of the biggest plant families on the earth. Iran has a huge diversity of Apiaceae members. This family possesses a range of compounds that have many biological activities. The members of this family are well known as vegetables, culinary and medicinal plants. Here, we present a review of ethnobotanical uses of Apiaceae plants by the Iranian people in order to provide a comprehensive documentation for future investigations. MATERIALS AND METHODS: We checked scientific studies published in books and journals in various electronic databases (Medline, PubMed, Science Direct, Scopus and Google Scholar websites) from 1937 to 2015 and reviewed a total of 52 publications that provided information about different applications of these plant species in human and livestock...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28074382/engaging-hmong-adults-in-genomic%C3%A2-and%C3%A2-pharmacogenomic-research-toward-reducing-health-disparities-in-genomic-knowledge-using-a-community-based-participatory-research-approach
#7
Kathleen A Culhane-Pera, Robert J Straka, MaiKia Moua, Youssef Roman, Pachia Vue, Kang Xiaaj, May Xia Lo, Mai Lor
Advancing precision medicine relies in part on examining populations that may exhibit unique genetic variants that impact clinical outcomes. Failure to include diverse populations in genomic-based research represents a health disparity. We implemented a community-based participatory research (CBPR) process with the Hmong community in Minnesota, who were refugees from Laos, in order to assess the feasibility of conducting genomic and pharmacogenomic-based research for genetic variants that are relevant to the Hmong community...
January 10, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28072712/seniorlab-a-prospective-observational-study-investigating-laboratory-parameters-and-their-reference-intervals-in-the-elderly
#8
Martin Risch, Urs Nydegger, Lorenz Risch
BACKGROUND: In clinical practice, laboratory results are often important for making diagnostic, therapeutic, and prognostic decisions. Interpreting individual results relies on accurate reference intervals and decision limits. Despite the considerable amount of resources in clinical medicine spent on elderly patients, accurate reference intervals for the elderly are rarely available. The SENIORLAB study set out to determine reference intervals in the elderly by investigating a large variety of laboratory parameters in clinical chemistry, hematology, and immunology...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28063849/recruitment-promotion-and-retention-of-women-in-academic-medicine-how-institutions-are-addressing-gender-disparities
#9
Phyllis L Carr, Christine Gunn, Anita Raj, Samantha Kaplan, Karen M Freund
OBJECTIVE: Greater numbers of women in medicine have not resulted in more women achieving senior positions. Programs supporting the recruitment, promotion, and retention of women in academic medicine could help to achieve greater advancement of more women to leadership positions. Qualitative research was conducted to understand such programs at 23 institutions and, using the social ecological model, examine how they operate at the individual, interpersonal, institutional, academic community, and policy levels...
January 4, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28060118/cytomegalovirus-treatment-in-pediatric-hematopoietic-stem-cell-transplant-patients
#10
Bethany A Wattles, Abby J Kim, Alexandra C Cheerva, Kenneth G Lucas, Joshua J Elder
Cytomegalovirus (CMV) is a frequent complication of hematopoietic stem cell transplant in pediatric patients, with significant morbidity and mortality. Antiviral drugs are used as prophylactic, preemptive or therapeutic medicines; however, no uniform guidelines exist for the best strategy to prevent CMV disease. Resistance to standard antiviral therapies can lead to further difficulty in managing CMV disease. Studies for investigational therapies are underway and could provide options for treatment of resistant CMV, while limiting toxicities associated with currently used antiviral therapies...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28054108/-cardiac-surgery-in-the-elderly
#11
B Wiegmann, I Ismai, A Haverich
Due to the increasing demographic changes and the fact that cardiovascular diseases are still the leading cause of death, the mean chronological age of patients undergoing cardiac surgery is steadily increasing. In 2015, 14.8% of these patients were aged 80 years and older. This meta-analysis reviewed if and under what circumstances elderly patients benefit from cardiac surgical procedures without running the risk of limitations in the quality of life and high rates of morbidity and mortality. Generally, the chronological age was not a risk factor for higher perioperative and postoperative morbidity and mortality but the biological age was the critical factor, in particular the associated comorbidities of patients and the timing of the surgical procedure in the course of the disease...
January 4, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28049124/personalised-medicine-in-asthma-from-curative-to-preventive-medicine
#12
REVIEW
Laurent Guilleminault, Hakima Ouksel, Chantal Belleguic, Yannick Le Guen, Patrick Germaud, Emilie Desfleurs, Christophe Leroyer, Antoine Magnan
The concept of asthma has changed substantially in recent years. Asthma is now recognised as a heterogeneous entity that is complex to treat. The subdivision of asthma, provided by "cluster" analyses, has revealed various groups of asthma patients who share phenotypic features. These phenotypes underlie the need for personalised asthma therapy because, in contrast to the previous approach, treatment must be tailored to the individual patient. Determination of the patient's asthma phenotype is therefore essential but sometimes challenging, particularly in elderly patients with a multitude of comorbidities and a complex exposure history...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28043897/natural-products-against-alzheimer-s-disease-pharmaco-therapeutics-and-biotechnological-interventions
#13
REVIEW
Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee, Devendra Kumar Pandey
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress...
December 30, 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/28041968/medicines-for-pediatric-patients-biopharmaceutical-developmental-and-regulatory-considerations
#14
David P Elder, René Holm, Martin Kuentz
This commentary reflects current developments in pediatric medicine. The underpinning legislation in both Europe and the US has led to the initiation of an increased number of clinical trials in the pediatric population, but there are still a number of outstanding issues within this field. These include the differences in the physiology between adults and the very heterogeneous nature of pediatric patients. There is an ongoing scientific debate on the applicability of a Pediatric Biopharmaceutical Classification System (PBCS) to define when waivers for bioequivalence studies can be supported by in vitro dissolution...
December 29, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28039932/potentially-inappropriate-medications-in-elderly-japanese-patients-effects-of-pharmacists-assessment-and-intervention-based-on-screening-tool-of-older-persons-potentially-inappropriate-prescriptions-criteria-ver-2
#15
T Kimura, F Ogura, K Yamamoto, A Uda, T Nishioka, M Kume, H Makimoto, I Yano, M Hirai
WHAT IS KNOWN AND OBJECTIVES: The Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (stopp) criteria were updated in 2014 (stopp criteria ver.2), but few studies have evaluated the usefulness of stopp criteria in elderly patients. This prospective observational study evaluated the prevalence of potentially inappropriate medications (PIMs), and the efficacy of hospital pharmacists' assessment and intervention based on stopp criteria ver.2. METHODS: The study was conducted at three medical units of Kobe University Hospital between April 2015 and March 2016...
December 31, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28038993/inflammaging-and-omics-in-human-longevity
#16
REVIEW
Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi
Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omic data - particularly on glycomics - collected on centenarians, supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli conceptualized as "molecular garbage"; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a "local fire" which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly informative set/combination of omic markers able to better grasp the complex molecular core of inflammaging in elderly and centenarians...
December 27, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28017466/trazodone-utilization-among-the-elderly-in-spain-a-population-based-study
#17
Diego Macías Saint-Gerons, Consuelo Huerta Álvarez, Patricia García Poza, Dolores Montero Corominas, César de la Fuente Honrubia
INTRODUCTION: Trazodone was authorized for the treatment of depression in the 1970s. Several additional therapeutic uses have been proposed due to its heterogeneous mechanism. This study aims to determine the use of trazodone in the elderly in Spain. METHODS: A nationwide, longitudinal and descriptive analysis was conducted using data from patients aged >65 years with a first prescription of trazodone during the period 2002-2011. Information on dose, comorbidities and relevant co-medication was gathered from the Spanish Primary Care database BIFAP...
December 21, 2016: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28011998/can-balneotherapy-improve-the-bowel-motility-in-chronically-constipated-middle-aged-and-elderly-patients
#18
Taner Dandinoglu, Ozgur Dandin, Tuncer Ergin, Deniz Tihan, Yasam Kemal Akpak, Oguz Ugur Aydın, Uygar Teomete
Balneotherapy or spa therapy is usually known for different application forms of medicinal waters and its effects on the human body. Our purpose is to demonstrate the effect of balneotherapy on gastrointestinal motility. A total of 35 patients who were treated for osteoarthritis with balneotherapy from November 2013 through March 2015 at our hospital had a consultation at the general surgery for constipation and defecation disorders. Patients followed by constipation scores, short-form health survey (SF-12), and a colonic transit time (CTT) study before and after balneotherapy were included in this study, and the data of the patients were analyzed retrospectively...
December 23, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28010994/pelvic-floor-muscle-training-for-secondary-prevention-of-pelvic-organ-prolapse-prevprol-a-multicentre-randomised-controlled-trial
#19
Suzanne Hagen, Cathryn Glazener, Doreen McClurg, Christine Macarthur, Andrew Elders, Peter Herbison, Don Wilson, Philip Toozs-Hobson, Christine Hemming, Jean Hay-Smith, Marissa Collins, Sylvia Dickson, Janet Logan
BACKGROUND: Pelvic floor muscle training can reduce prolapse severity and symptoms in women seeking treatment. We aimed to assess whether this intervention could also be effective in secondary prevention of prolapse and the need for future treatment. METHODS: We did this multicentre, parallel-group, randomised controlled trial at three centres in New Zealand and the UK. Women from a longitudinal study of pelvic floor function after childbirth were potentially eligible for inclusion...
December 20, 2016: Lancet
https://www.readbyqxmd.com/read/28010940/-profile-of-heart-failure-according-to-the-department-of-admission-implications-for-multidisciplinary-management
#20
Lourdes Vicent, Ana Ayesta, María Teresa Vidán, José María de Miguel-Yanes, Jorge García, María Tamargo, Víctor Gómez, Samuel Véliz, Francisco Fernández-Avilés, Manuel Martínez-Sellés
INTRODUCTION: Population aging has led to notable changes in heart failure admissions. The aim of this study was to analyse the characteristics, comorbidity, management, and outcomes of this patient population in three hospital departments. METHODS: An analysis was made of a prospective register that included all patients admitted due to heart failure in Internal Medicine, Cardiology, and Geriatrics over a period of 45 days. RESULTS: Of a total of 235 patients, 124 (52...
December 20, 2016: Revista Española de Geriatría y Gerontología
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