Xiao Ma, Paul M McKie, Seethalakshmi R Iyer, Christopher Scott, Kent Bailey, Bradley K Johnson, Sherry L Benike, Horng Chen, Wayne L Miller, Aderville Cabassi, John C Burnett, Valentina Cannone
Hypertension and metabolic syndrome frequently coexist to increase the risk for adverse cardiometabolic outcomes. To date, no drug has been proven to be effective in treating hypertension with metabolic syndrome. M-atrial natriuretic peptide is a novel atrial natriuretic peptide analog that activates the particulate guanylyl cyclase A receptor. This study conducted a double-blind, placebo-controlled trial in 22 patients and demonstrated that a single subcutaneous injection of M-atrial natriuretic peptide was safe, well-tolerated, and exerted pleiotropic properties including blood pressure-lowering, lipolytic, and insulin resistance-improving effects...
January 2024: JACC. Basic to Translational Science