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https://www.readbyqxmd.com/read/29691992/breastfeeding-and-growth-during-infancy-among-offspring-of-mothers-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#1
E P Gunderson, L C Greenspan, M S Faith, S R Hurston, C P Quesenberry
BACKGROUND: Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated. OBJECTIVES: The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM). METHODS: Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other)...
April 24, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29691964/transition-to-adult-diabetes-care-in-germany-high-risk-for-acute-complications-and-declining-metabolic-control-during-the-transition-phase
#2
T M Kapellen, S Müther, A Schwandt, J Grulich-Henn, B Schenk, K O Schwab, W Marg, R W Holl
OBJECTIVE: There is evidence that transition from pediatric to adult health care is frequently associated with deterioration of health in youths with type 1 diabetes (T1D). The aim of this study was to compare metabolic control, acute complications and microvascular complications in adolescents and young adults before and after transfer to an adult treatment center with respect to the time between first visit in the adult center and last visit in pediatric treatment. METHODS: All data were collected during routine care and retrieved from the German/Austrian DPV database...
April 25, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29691953/circulating-mots-c-levels-are-decreased-in-obese-male-children-and-adolescents-and-associated-with-insulin-resistance
#3
Caiqi Du, Cai Zhang, Wei Wu, Yan Liang, Anru Wang, Shimin Wu, Yue Zhao, Ling Hou, Qin Ning, Xiaoping Luo
BACKGROUND AND AIMS: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. METHODS: In this case-control study, 40 obese children and adolescents (27 males) and 57 controls (40 males) were recruited in the Hubei Province of China in 2017...
April 25, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29691887/correlate-of-burden-and-coping-ability-of-caregivers-of-older-adults-with-chronic-illness-in-nigeria
#4
Joel Olayiwola Faronbi
AIM: Caring for older adults with chronic illness is associated with enormous physical and psychological stress on the informal caregivers. This study assessed burden experienced by caregivers of older adults with chronic illness, explored coping strategies of caregivers in relation to identified chronic conditions and determined the influence of caregiver's burden, caregiver's characteristics and older adult's characteristics on their coping ability. METHOD: This is a cross-sectional, correlational study, and data were collected among 325 caregivers of older adults living with chronic illness in Osun State, Nigeria, using a checklist, Katz IADL, Zarit Burden Interview and Brief Cope Scale...
April 25, 2018: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29691808/total-body-irradiation-for-hematopoietic-stem-cell-transplantation-during-early-childhood-is-associated-with-the-risk-for-diabetes-mellitus
#5
Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies and related diseases. Recently, the long-term prognosis of HSCT during childhood has greatly improved; however, the late adverse effects of HSCT have been found to cause substantial morbidity among long-term survivors. Although metabolic complications, such as diabetes mellitus (DM) and hyperlipidemia (HL), are the major late effects of pediatric HSCT, the clinical details are not clarified sufficiently...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691757/microbiota-transplantation-concept-methodology-and-strategy-for-its-modernization
#6
REVIEW
Faming Zhang, Bota Cui, Xingxiang He, Yuqiang Nie, Kaichun Wu, Daiming Fan
Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gut-brain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future...
April 24, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29691708/generation-of-insulin-deficient-piglets-by-disrupting-ins-gene-using-crispr-cas9-system
#7
Bumrae Cho, Su Jin Kim, Eun-Jin Lee, Sun Mi Ahn, Jin Seok Lee, Dal-Young Ji, Kiho Lee, Jung-Taek Kang
Diabetes mellitus is a chronic disease with accompanying severe complications. Various animal models, mostly rodents due to availability of genetically modified lines, have been used to investigate the pathophysiology of diabetes. Using pigs for diabetic research can be beneficial because of their similarity in size, pathogenesis pathway, physiology, and metabolism with human. However, the use of pigs for diabetes research has been hampered due to only few pig models presenting diabetes symptoms. In this study, we have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer...
April 24, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29691621/clinical-impact-of-preoperative-sarcopenia-on-the-postoperative-outcomes-after-pancreas-transplantation
#8
Yasunari Fukuda, Tadafumi Asaoka, Hidetoshi Eguchi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Toshinori Ito, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
BACKGROUND: The importance of evaluating sarcopenia is increasingly being recognized in the field of transplantation because sarcopenia can have an adverse effect on the treatment outcomes. However, the clinical significance of preoperative sarcopenia on the postoperative outcomes following pancreas transplantation (PTx) has been largely unknown. The objective of this study was to investigate the role of preoperative sarcopenia in predicting the postoperative outcomes following PTx in recipients with type 1 diabetes mellitus (T1D)...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29691600/a-proinflammatory-cd4-t-cell-phenotype-in-gestational-diabetes-mellitus
#9
Angela Sheu, Yixian Chan, Angela Ferguson, Mohammad B Bakhtyari, Wendy Hawke, Chris White, Yuk Fun Chan, Patrick J Bertolino, Heng G Woon, Umaimainthan Palendira, Frederic Sierro, Sue Mei Lau
AIMS/HYPOTHESIS: Numerous adaptations of the maternal immune system are necessary during pregnancy to maintain immunological tolerance to the semi-allogeneic fetus. Several complications of pregnancy have been associated with dysregulation of these adaptive mechanisms. While gestational diabetes mellitus (GDM) has been associated with upregulation of circulating inflammatory factors linked to innate immunity, polarisation of the adaptive immune system has not been extensively characterised in this condition...
April 24, 2018: Diabetologia
https://www.readbyqxmd.com/read/29691285/relationships-between-chronic-comorbidities-and-the-atherosclerosis-indicators-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-in-patients-with-type-2-diabetes-mellitus
#10
Chun-Chuan Lee, Ming-Chieh Tsai, Sung-Chen Liu, Chi-Feng Pan
This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis...
April 24, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29691170/outcomes-of-articulating-spacers-with-autoclaved-femoral-components-in-total-knee-arthroplasty-infection
#11
Daniel E Goltz, E Grant Sutter, Michael P Bolognesi, Samuel S Wellman
BACKGROUND: In 2-stage revision of total knee arthroplasty (TKA) infection, articulating antibiotic spacers show similar eradication rates and superior range of motion compared with static spacers. This study evaluated infection control and other outcomes in articulating spacers with an autoclaved index femoral component. METHODS: We reviewed 59 patients who underwent 2-stage treatment of TKA infection using articulating antibiotic spacers with an autoclaved femoral component with at least 2-year follow-up (mean: 5...
March 30, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29691071/incidence-determinants-and-clinical-impact-of-definite-stent-thrombosis-on-mortality-in-women-from-the-win-des-collaborative-patient-level-pooled-analysis
#12
Laura S Kerkmeijer, Bimmer E Claessen, Usman Baber, Samantha Sartori, Jaya Chandrasekhar, Giulio G Stefanini, Gregg W Stone, P Gabriel Steg, Alaide Chieffo, Giora Weisz, Stephan Windecker, Ghada W Mikhail, Adnan Kastrati, Marie-Claude Morice, George D Dangas, Robbert J de Winter, Roxana Mehran
BACKGROUND: Predictors and clinical outcomes of stent thrombosis (ST) in women have not been well investigated. Present study aimed to identify predictors of definite ST and its impact on mortality in women undergoing percutaneous coronary intervention (PCI). METHODS: Patient-level data of women enrolled in 26 randomized trials of DES was pooled. The study population was stratified based on the presence or absence of definite ST. Cox proportional hazards models were used to determine the predictors of definite ST...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29691065/clinical-assessment-and-treatment-of-diabetes-in-patients-with-chronic-kidney-disease
#13
J Carretero Gómez, J C Arévalo Lorido
Diabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24.7% of patients. The prevalence of microalbuminuria, proteinuria and a reduced glomerular filtration rate is 36%, 8% and 22%, respectively. The presence of albuminuria is a predictor of chronic kidney disease. Diabetic kidney disease, previously known as diabetic nephropathy, refers to kidney disease caused by diabetes...
April 21, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29690979/sofosbuvir-causing-diabetes-mellitus-is-there-a-link
#14
Sumerah Jabeen, Owais Rashid, Saira Furqan
No abstract text is available yet for this article.
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29689724/association-between-plasma-levels-of-pai-1-tpa-pai-1-molar-ratio-and-mild-cognitive-impairment-in-chinese-patients-with-type-2-diabetes-mellitus
#15
Jiaqi Wang, Yang Yuan, Rongrong Cai, Rong Huang, Sai Tian, Hongyan Lin, Dan Guo, Shaohua Wang
BACKGROUND: Plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (tPA) are involved in the complications of type 2 diabetes mellitus (T2DM) and early pathology of Alzheimer's disease. OBJECTIVE: This study aimed to investigate the association between plasma PAI-1, tPA/PAI-1 molar ratio, and mild cognitive impairment (MCI) in Chinese T2DM patients. METHODS: A total of 162 Chinese T2DM patients were recruited and divided into two groups according to the Montreal Cognitive Assessment score...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689322/polycystic-ovary-syndrome-and-hyperglycaemia-in-pregnancy-a-narrative-review-and-results-from-a-prospective-danish-cohort-study
#16
REVIEW
Camilla Viola Buskbjerg Palm, Dorte Glintborg, Henriette Boye Kyhl, H David McIntyre, Richard Christian Jensen, Tina Kold Jensen, Dorte Møller Jensen, Marianne Andersen
BACKGROUND: Insulin resistance is common in polycystic ovary syndrome (PCOS). PCOS may be associated with increased risk of gestational diabetes mellitus (GDM). OBJECTIVES: To 1) review literature regarding PCOS and hyperglycaemia in pregnancy and 2) present original data from Odense Child Cohort (OCC) regarding GDM in PCOS. METHODS: Literature search including original studies from 2000-18. OCC included 2,548 pregnant women, 9.5 % (n=241) had PCOS...
April 21, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29689321/gestational-weight-gain-and-weight-loss-among-women-with-gestational-diabetes-mellitus
#17
Daphna Komem, Lina Salman, Eyal Krispin, Nissim Arbib, Ron Bardin, Arnon Wiznitzer, Eran Hadar
AIMS: To assess the association of gestational weight gain or loss with adverse pregnancy outcome among women with gestational diabetes mellitus (GDM). METHODS: Retrospective study of all women diagnosed with GDM, from July 2012 to December 2016, stratified by gestational weight change according to the institute of medicine recommendations. Primary maternal outcome was glycemic control and primary neonatal outcome was large or small for gestational age (LGA or SGA)...
April 21, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29689277/butyrate-ameliorated-nlrc3-protects-the-intestinal-barrier-in-a-gpr43-dependent-manner
#18
Di Cheng, Ji-Hao Xu, Jie-Yao Li, Si-Yi Wang, Ting-Feng Wu, Qi-Kui Chen, Tao Yu
BACKGROUND: Intestinal barrier dysfunctions are related to dysbacteriosis and chronic gut inflammation in type 2 diabetes. Although there is emerging evidence that the chronic gut inflammatory response is stimulated by nucleotide-binding oligomerization domain-like receptors (NLRs), the relationship and precise mechanism between NLRC3 and the colonic epithelial barrier remains largely elusive. METHODS: We investigated the function and mechanism of NLRC3 in the colonic tissues of diabetic mice and colonic epithelial cell lines...
April 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29689124/increasing-incidence-of-type-2-diabetes-in-new-zealand-children-15-years-of-age-in-a-regional-based-diabetes-service-auckland-new-zealand
#19
Natalia Sjardin, Peter Reed, Ben Albert, Fran Mouat, Phillipa J Carter, Paul Hofman, Wayne Cutfield, Alistair Gunn, Craig Jefferies
AIM: It is important to understand whether type 2 diabetes mellitus (T2DM) is increasing in childhood for health-care planning and clinical management. The aim of this study is to examine the incidence of T2DM in New Zealand children, aged <15 years from a paediatric diabetes centre, Auckland, New Zealand. METHODS: Retrospective analysis of prospectively collected data from a population-based referral cohort from 1995 to 2015. RESULTS: Hundred and four children presented with T2DM over the 21-year period...
April 24, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29689109/maternal-vitamin-d-deficiency-increases-the-risk-of-adverse-neonatal-outcomes-in-the-chinese-population-a-prospective-cohort-study
#20
Yuanliu Wang, Honghui Li, Min Zheng, Yubi Wu, Ting Zeng, Jinjian Fu, Dingyuan Zeng
BACKGROUND: Although vitamin D (vitD) deficiency is a common problem in pregnant women, in China, few studies have focused on the relationship between maternal vitD deficiency throughout the three trimesters and subsequent neonatal outcomes in China. METHODS: Between 2015 and 2016, maternal serum and neonate cord blood samples were collected from 1978 mother-neonate pairs from Liuzhou city. RESULTS: The mean concentrations of 25-hydroxy vitD (25(OH)D) were 16...
2018: PloS One
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