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https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#1
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29913317/evaluation-of-knowledge-regarding-gestational-diabetes-mellitus-a-bangladeshi-study
#2
B Bhowmik, F Afsana, T Ahmed, T Siddiquee, T Ahmed, F Pathan, H Mahtab, A K A Khan
OBJECTIVE: The aim of this study was to evaluate the level of knowledge about gestational diabetes mellitus (GDM) in Bangladeshi people. STUDY DESIGN: Cross-sectional study. METHODS: This study involving 1374 participants was conducted in 15 outpatient clinics of Diabetic Association of Bangladesh and its affiliated associations, Bangabandhu Sheikh Mujib Medical University and four medical college hospitals in Bangladesh from August 2015 to December 2015...
June 15, 2018: Public Health
https://www.readbyqxmd.com/read/29913257/lipofibromas-are-not-related-to-diabetes-mellitus-or-obesity
#3
Daniel Mettman, Garth R Fraga
No abstract text is available yet for this article.
June 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29913182/the-genetic-architecture-of-type-1-diabetes-mellitus
#4
REVIEW
Denis M Nyaga, Mark H Vickers, Craig Jefferies, Jo K Perry, Justin M O'Sullivan
Type 1 diabetes mellitus (T1D) is a complex autoimmune disorder characterised by loss of the insulin-producing pancreatic beta cells in genetically predisposed individuals, ultimately resulting in insulin deficiency and hyperglycaemia. T1D is most common among children and young adults, and the incidence is on the rise across the world. The aetiology of T1D is hypothesized to involve genetic and environmental factors that result in the T-cell mediated destruction of pancreatic beta cells. There is a strong genetic risk to T1D; with genome-wide association studies (GWAS) identifying over 60 susceptibility regions within the human genome which are marked by single nucleotide polymorphisms (SNPs)...
June 15, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29913163/loss-of-function-mutation-of-serine-racemase-attenuates-retinal-ganglion-cell-loss-in-diabetic-mice
#5
Haiyan Jiang, Jinlin Du, Juan Song, Yanqi Li, Mengjuan Wu, Jing Zhou, Shengzhou Wu
Consistent results suggest the promoting roles of serine racemase (SR)/D-serine in retinal neurodegeneration in diabetic retinopathy (DR). However, the direct evidence connecting SR deficiency with retinal neuroprotection in genetic model of diabetes mellitus has not been reported. In this investigation, we explore the effect of absence of functional SR on the degeneration of retinal ganglion cells (RGCs) with a diabetic murine model, Ins2Akita mice. We established a murine strain with double mutation, termed Ins2Akita -Srr, by mating heterozygous Ins2Akita mice with homozygous Srrochre269 mice...
June 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29912982/discovery-of-a-novel-potent-peptide-agonist-to-adiponectin-receptor-1
#6
Sunghwan Kim, Younho Lee, Jun Woo Kim, Young-Jin Son, Min Jung Ma, Jee-Hyun Um, Nam Doo Kim, Sang Hyun Min, Dong Il Kim, Brian B Kim
Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin...
2018: PloS One
https://www.readbyqxmd.com/read/29912760/the-role-of-insulin-like-growth-factor-igf-axis-in-early-diagnosis-of-pancreatic-adenocarcinoma-pdac
#7
Barbara Wlodarczyk, Anita Gasiorowska, Ewa Malecka-Panas
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912623/saxagliptin-upregulates-nesfatin-1-secretion-and-ameliorates-insulin-resistance-and-metabolic-profiles-in-type-2-diabetes-mellitus
#8
Kuanlin Chen, Tiejun Zhuo, Jian Wang, Qing Mei
BACKGROUND AND AIMS: Saxagliptin as one of dipeptidyl peptidase-4 (DPP-4) inhibitors can effectively improve glycaemic control in type 2 diabetes mellitus, and nesfatin-1 is regarded as a very important factor in regulating feeding behavior and energy homeostasis. In this trial, we observed the effect of saxagliptin on regulating nesfatin-1 secretion and ameliorating insulin resistance and metabolic profiles in type 2 diabetes mellitus. METHODS: One hundred two type 2 diabetes participants (M/F = 48/54) were investigated...
June 18, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29912482/increasing-beta-cell-mass-to-treat-diabetes-mellitus
#9
REVIEW
Shakila Sabir, Ammara Saleem, Muhammad Furqan Akhtar, Muhammad Saleem, Moosa Raza
Finding a radical cure for diabetes has reached paramount importance in medicine due to the widespread prevalence of the disease. A substantial reduction in insulin-secreting beta cells is evident in diabetes. The failure of cyclin-dependent kinases (CDKs) and cyclins to access the nucleus is responsible for quiescence or senescence in human and rodent beta cells. The augmentation of beta cell proliferation is supposed to reverse diabetes. This concept has inspired the discovery of newer drugs that encourage the proliferation of beta cells...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29912386/impairment-of-the-akt-pathway-in-transplanted-type-1-diabetic-hearts-is-associated-with-post-transplant-graft-injury
#10
Sevil Korkmaz-Icöz, Shiliang Li, Sivakkanan Loganathan, Tamás Radovits, Mihály Ruppert, Paige Brlecic, Alex Ali Sayour, Gábor Veres, Thomas Fleming, Maik Brune, Patrick Most, Matthias Karck, Gábor Szabó
OBJECTIVES: The use of 'marginal' hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the diabetic myocardium. We hypothesized that DM-induced cardiac dysfunction in donors is further impaired after heart transplantation and that PI3K/Akt-pathway alterations may be one of the underlying pathomechanisms...
June 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29912014/re-incidence-and-risk-factors-for-prediabetes-and-diabetes-mellitus-among-hiv-infected-adults-on-antiretroviral-therapy
#11
Lifeng Lin
No abstract text is available yet for this article.
June 14, 2018: Epidemiology
https://www.readbyqxmd.com/read/29911959/conversion-from-steroid-to-everolimus-in-maintenance-kidney-transplant-recipients-with-posttransplant-diabetes-mellitus
#12
Koji Nanmoku, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Takashi Yagisawa
OBJECTIVES: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy. MATERIALS AND METHODS: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg)...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29911757/reduction-in-serum-triglyceride-levels-in-diabetic-patients-may-result-in-decreased-insulin-dependence-and-disease-regression
#13
Nadav Shinhar, Dana Marcoviciu, Dror Dicker
BACKGROUND: Type 2 diabetes mellitus is a multifactorial disease in which genetic susceptibility and environmental factors induce pancreatic β-cell dysfunction and insulin resistance. Additional factors such as hyperglycemia and hyperlipidemia have roles in β-cell dysfunction and disease progression. The phenomenon of lipid-induced pancreatic β-dysfunction, designated as lipotoxicity, has been observed in several in vitro and in vivo experiments; however, there is still no solid evidence for the occurrence of this event in humans...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911451/effect-of-well-controlled-gestational-diabetes-on-left-ventricular-diastolic-dysfunction-in-neonates
#14
Yazdan Ghandi, Danial Habibi, Khadijeh Nasri, Saeed Alinejad, Hassan Taherahmad, Ali Arjmand Shabestari, Ali Nematinejad
BACKGROUND: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium. MATERIALS AND METHODS: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth...
June 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29911403/how-4-companies-became-one-co-development-under-an-outsourced-model-with-focus-on-phase-3-analysis-and-reporting-deliverables
#15
Susan Huyck, Gregory Golm, Sajda Ghani, James Mancuso, Tarra Irvin
With the growth in co-development deals between pharmaceutical companies and the increased use of contract research organizations (CROs) in drug development, more and more employees are encountering projects that require working across different companies. Navigating the mix of corporate cultures as well as variations in standards and procedures can lead to unanticipated challenges and delays. The development of ertugliflozin, a recently approved medicine for type 2 diabetes mellitus, involved both co-development and CRO engagement across 4 companies...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29911306/chronic-subcutaneous-infection-due-to-lichtheimia-ramosa
#16
Chengfang Geng, Xuelian Lv, Jie Li, Qing Jiang, Rongya Yang, Ping Zhan
Lichtheimia (formerly Absidia), is a genus of saprotrophic zygomycetous fungi which causes invasive mucormycosis in immunocompromised human hosts, e.g, patient with haematological malignancy, neutropenia, diabetes mellitus and organ transplantations, as well as long period of corticosteroid and immunosuppressant application. There has been an increase of Lichtheimia infections worldwide and the most common agents are reported to be Lichtheimia corymbifera. Primary cutaneous and subcutaneous infection is usually associated with immunodeficiency or trauma and presents as locally invasive, very rapid aggressive lesions due to this fungi's ability of angioinvasion...
June 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29911075/trace-element-status-in-type-2-diabetes-a-meta-analysis
#17
Namrata Sanjeevi, Jeanne Freeland-Graves, S Natasha Beretvas, Prageet K Sachdev
Introduction: Type 2 diabetes is a chronic metabolic disorder that has been associated with alterations in the status of trace elements, including zinc, copper, iron and manganese. However, clinical studies reporting statuses of these trace elements in type 2 diabetes patients compared to controls have shown conflicting results. Objective: This meta-analysis aimed to summarize the existing literature on the statuses of zinc, copper, iron, and manganese in Type 2 diabetes mellitus patients...
May 2018: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29911060/salivary-and-serum-aspartate-aminotransferases-and-alanine-aminotransferases-in-insulin-dependent-diabetes-mellitus-and-normal-children-a-comparative-study
#18
K S Vinod, Lal P Madathil, Pushparaja Shetty, Harsimran Kaur, Mimansha Patel, Abhishek Gouraha
Aims and Objectives: The aim of the study was to estimate and compare aspartate aminotransferases (AST) and alanine aminotransferases (ALT) levels in saliva and serum of insulin-dependent diabetes mellitus (IDDM) and normal children, and the objective was to evaluate the significance of these enzymes in assessing the salivary gland injury in IDDM children. Materials and Methods: The study group comprised of thirty children clinically and biochemically diagnosed for IDDM and thirty healthy children of similar age in the control group...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29911046/vaccination-status-knowledge-and-acceptance-of-adult-vaccinations-against-respiratory-illness-among-patients-with-type-2-diabetes-mellitus
#19
Christeena Geneev, Nisha Mathew, Jubbin Jagan Jacob
Patients with diabetes mellitus are more prone to develop infections with influenza virus and pneumococcus. Once they develop respiratory infections, they are twice more likely to die of complication related to the infection. Although there are no Indian guidelines, recent publications have recommended vaccination in patients with diabetes of all ages. Our study was undertaken to find the barriers to the uptake of adult vaccination against respiratory illness among patients with diabetes attending a diabetic clinic in a tertiary care institution...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911043/polycystic-ovary-syndrome-and-periodontal-disease-underlying-links-a-review
#20
REVIEW
Sri Chandana Tanguturi, Sreenivas Nagarakanti
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, which negatively affects various health systems. There is an extensive literature regarding the association of PCOS and other systemic conditions such as diabetes mellitus, cardiovascular disease, and psychological disorders. However, there is a lack of literature in associating PCOS and periodontal disease. Hence, PubMed search was done for various articles related to PCOS and its association with other comorbidities, including periodontal diseases...
March 2018: Indian Journal of Endocrinology and Metabolism
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