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https://www.readbyqxmd.com/read/29458218/effects-of-curcuminoids-plus-piperine-on-glycemic-hepatic-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#1
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Luis E Simental-Mendía, Muhammed Majeed, Amirhossein Sahebkar
INTRODUCTION: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients. METHODS: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months...
February 19, 2018: Drug Research
https://www.readbyqxmd.com/read/29458204/a-review-of-implantable-biosensors-for-closed-loop-glucose-control-and-other-drug-delivery-applications
#2
Kee Scholten, Ellis Meng
Closed-loop drug delivery promises autonomous control of pharmacotherapy through the continuous monitoring of biomarker levels. For decades, researchers have strived for portable closed-loop systems, capable of treating ambulatory patients with chronic conditions such as diabetes mellitus. After years of development, the first of these systems have left the laboratory and entered commercial use. This long-awaited advance reflects recent development of chronically stable implantable biosensors, able to accurately measure biomarker levels in vivo...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458056/alcohol-and-cv-health-jekyll-and-hyde-j-curves
#3
REVIEW
Evan L O'Keefe, James J Di Nicolantonio, James H O'Keefe, Carl J Lavie
A routine of light or moderate alcohol consumption (≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US)...
February 16, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29458015/sulfenamide-and-sulfonamide-derivatives-of-metformin-can-exert-anti-coagulant-and-pro-fibrinolytic-properties
#4
Magdalena Markowicz-Piasecka, Kristiina M Huttunen, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Joanna Sikora
Type 2 diabetes mellitus (T2DM) is characterised not only by hyperglycaemia and insulin resistance but also an impaired balance between the processes of coagulation and fibrinolysis. The aim of this study was to examine the effects of metformin, a widely-used oral anti-diabetic drug, phenformin and eight sulfenamide and sulfonamide derivatives of metformin on several haemostasis parameters. Thrombin Time (TT) tests were performed according to the available commercial method. The activity of factor X was conducted based on deficient plasma factor X...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457841/erectile-dysfunction-they-don-t-talk-we-don-t-ask
#5
A Rakovac Tisdall, T F J King, W A W Mahmood, C S Keat, R Ali, R Abdin, C M Koo, M Alali, S Sreenan, J H McDermott
Erectile dysfunction is an under-reported complication of diabetes mellitus affecting over half of male patients [1]. Although many men with diabetes consider that erectile dysfunction has a negative influence on their quality of life, they are reluctant to report it; and while most would like treatment, they prefer physicians to start the conversation [2-4]. Erectile dysfunction predicts future cardiovascular disease, and screening for erectile dysfunction is advocated in several cardiovascular risk assessment algorithms [5]...
February 19, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29457694/exploring-self-management-on-glycemic-control-using-a-modified-information-motivation-behavioral-skills-model-in-type-2-diabetes-mellitus-patients-in-shanghai-china-a-cross-sectional-study
#6
Qi Chen, Huwen Wang, Yichen Wang, Zezhou Wang, DaiJun Zhao, Yong Cai
BACKGROUND: The utility and maturity of the original Information-Motivation-Behavioral Skills (IMB) model have been verified in Type 2 Diabetes Mellitus (T2DM) patients. But little research has clarified whether the model has effect on glycemic control. The main purpose of this study is to modify the IMB model to explore self-management on glycemic control in T2DM patients in Shanghai, China. METHODS: A cross-sectional study was conducted using a convenience sampling method between June and August 2015 in three tertiary hospitals and four community health service centers...
February 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29457265/the-role-of-type-2-diabetes-mellitus-on-hypertensive-related-aortic-stiffness
#7
Edoardo Sciatti, Enrico Vizzardi, Assunta Castiello, Francesca Valentini, Ivano Bonadei, Sandro Gelsomino, Roberto Lorusso, Marco Metra
BACKGROUND: Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. METHODS: We prospectively enrolled outpatients with hypertension (n = 99) and type 2 diabetes mellitus plus hypertension (n = 42) without cardiovascular events...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29456958/etiology-of-noise-induced-hearing-loss-nihl-and-its-symptomatic-correlation-with-audiometry-observations-in-type-ii-diabetes
#8
Meena K Yadav, K S Yadav
Type II diabetic mellitus (DM) is a chronic metabolic disease that impairs normal insulin production and glucose transport to the liver and muscles. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. DM chronic auditory complications may include spiral ganglia atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibres, and thickening of the capillary walls of the stria vascularis and small arteries...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456938/deep-neck-space-infections-a-study-in-diabetic-population-in-a-tertiary-care-centre
#9
Kalpana Sharma, Devjani Das, Manish Joshi, Dipjyoti Barman, A J Sarma
This study is intended to analyze the clinical profile and outcomes of deep neck space infection in diabetic patients in our tertiary care centre. A prospective study of 1 year duration from 30th September 2015 to 30th September 2016 at department of Otorhinolaryngology, Gauhati Medical College and Hospital, Guwahati. A total of 45 diabetic patients who presented with DNSI are included in this study. Their demographic profile, etiology, bacteriology, treatment, duration of hospital stay, complications and outcomes have been analyzed...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456855/metformin-and-aspirin-treatment-could-lead-to-an-improved-survival-rate-for-type-2-diabetic-patients-with-stage-ii-and-iii-colorectal-adenocarcinoma-relative-to-non-diabetic-patients
#10
Ariella De Monte, Davide Brunetti, Luigi Cattin, Francesca Lavanda, Erica Naibo, Maria Malagoli, Giorgio Stanta, Serena Bonin
Metformin, the drug of choice in the treatment of type 2 diabetes mellitus (DM2), in addition to aspirin (ASA), the drug prescribed for cardioprotection of diabetic and non-diabetic patients, have an inhibitory effect on cancer cell survival. The present population-based study conducted in the province of Trieste (Italy), aimed to investigate the prevalence of DM2 in patients with colorectal adenocarcinoma (CRC) and survival for CRC in diabetic and nondiabetic patients. All permanent residents diagnosed with a CRC between 2004 and 2007 were ascertained through the regional health information system...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456698/correlation-of-blood-glucose-serum-chemerin-and-insulin-resistance-with-nafld-in-patients-with-type-2-diabetes-mellitus
#11
Zhengjun Zhang, Jijun Wang, Hongmei Wang
Non-alcoholic fatty liver disease (NAFLD) is a form of clinical syndrome characterized by the fatty degeneration in liver histology and should be further investigated. The aim of the study was to investigate the effects of blood glucose, serum chemerin and insulin resistance on non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus to provide a basis for the prevention and treatment thereof. In total, 300 patients with type 2 diabetes mellitus treated and admitted into the Endocrinology Department of our hospital from June 2015 to June 2017 were enrolled and divided into the simple type 2 diabetes mellitus (group A) and concurrent NAFLD (group B) groups...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456697/relationship-between-fat-mass-and-obesity-associated-gene-expression-and-type-2-diabetes-mellitus-severity
#12
Qiuling Wang, Jinhuan Wang, Haixia Lin, Xuechen Huo, Qiaoling Zhu, Min Zhang
This study sought to investigate any correlation between fat mass and obesity-associated gene (FTO) expression and the severity of type 2 diabetes mellitus (T2DM). In total 110 patients newly diagnosed with T2DM in the outpatient department of Yantai Yuhuangding Hospital between September 2016 and March 2017 were selected as study subjects and were divided into severe (58 cases) and mild groups (52 cases) according to T2DM severity. Patients in the severe group were followed up for 12 weeks. An additional 60 healthy individuals were selected to serve as the normal control group...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456675/correlation-between-ppar-%C3%AE-methylation-level-in-peripheral-blood-and-atherosclerosis-of-nafld-patients-with-dm
#13
Jianghua Ju, Qingxian Huang, Jing Sun, Xiaoyun Zhao, Xiuli Guo, Yongcheng Jin, Wenjie Ma, Wenhui Wang
We investigated the correlation between the methylation levels of peroxisome proliferator-activated receptor-α (PPAR-α) in the peripheral blood and atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus (DM). A total of 50 normal subjects (group N) and 50 NAFLD patients with DM (group M) were selected at Qilu Hospital of Shandong University. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in groups N and M were detected...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456639/analysis-of-effect-of-1%C3%AE-hydroxyvitamin-d3-on-benign-paroxysmal-positional-vertigo-and-risk-factors
#14
Xiang Gu, Feilin Dong, Jianhua Gu
The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). Fifty BPPV patients diagnosed in the ENT Department of Anzhen Hospital from October 2015 to December 2016 were randomly selected as the treatment group, and treated with 0.25 µg 1α-hydroxyvitamin D3 once per day, in addition to the routine diagnosis and treatment. Moreover, 50 BPPV patients in the same period were selected as the control group, and received the routine diagnosis and treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456619/a-systematic-review-of-the-literature-exploring-the-interplay-between-prostate-cancer-and-type-two-diabetes-mellitus
#15
REVIEW
Danielle Crawley, Florence Chamberlain, Hans Garmo, Sarah Rudman, Björn Zethelius, Lars Holmberg, Jan Adolfsson, Par Stattin, Paul Carroll, Mieke Van Hemelrijck
Prostate cancer (PCa) and type two diabetes mellitus (T2DM) are both increasing prevalent conditions and often occur concurrently. However, the relationship between the two is more complex than just two prevalent conditions co-existing. This review systematically explores the literature around the interplay between the two conditions. It covers the impact of pre-existing T2DM on PCa incidence, grade and stage, as well as exploring the impact of T2DM on PCa outcomes and mortality and the interaction between T2DM and PCa treatments...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29456567/influence-of-blood-glucose-level-on-the-prognosis-of-patients-with-diabetes-mellitus-complicated-with-ischemic-stroke
#16
REVIEW
Xiao-Liu Dong, Fei Guan, Shi-Jun Xu, Li-Xia Zhu, Pan-Pan Zhang, Ai-Bin Cheng, Tie-Jun Liu
We carried out this meta-analysis for the aim of exploring the influence of diabetes mellitus (DM) on the prognosis of patients with ischemic stroke. Relevant studies were identified using computerized databases supplemented with manual search strategies. The included studies were strictly followed the inclusion and exclusion criteria. Case-control studies which related to the influence of DM on the prognosis of patients with ischemic stroke were selected. Statistical analyses were implemented with the STATA version 12...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29456372/drug-drug-interaction-related-uncontrolled-glycemia
#17
Mohamed Anwar Hammad, Balamurugan Tangiisuran, Abeer Mohamed Kharshid, Noorizan Abdul-Aziz, Yahaya Hassan, Nor Azizah Aziz, Tarek Mohamed Elsayed
Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes. Settings and Design: A cross-sectional study was conducted in Penang General Hospital. Methods: A computerized system for DDI checking was used to assess the severity and mechanism of DDIs...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456347/the-evolving-pattern-and-outcome-of-stroke-at-moderate-altitude
#18
Deepika Dhiman, Sanjay K Mahajan, Sudhir Sharma, Rajiv Raina
Background: The people residing in hills of this Sub-Himalayan region traditionally have a distinct lifestyle involving high level of physical activity. However, increased urbanization in the last two decades has led to changes in lifestyle of people. The present study was an endeavor to document changes in the pattern of stroke in people residing at moderate altitude. Aim: This study was aimed to study the evolving trends in clinical profile, risk factors, and outcome at 3 months in hospitalized patients of stroke in a Tertiary Care Hospital situated at moderate altitude...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456342/immune-mediated-neuropathies-our-experience-over-3-years
#19
Sadanandavalli Retnaswami Chandra, Venkata Raviteja Karru, M A Mukheem Mudabbir, Subashree Ramakrishnan, Anitha Mahadevan
Introduction: Immune-mediated peripheral neuropathy is the term applied to a spectrum of peripheral nerve disorders where immune dysregulation plays a role. Therefore, they are treatable. We analyzed the cases seen in the past 3 years by us and evaluated the clinical, laboratory, and outcome parameters in these patients. Patients and Methods: Consecutive patients seen by the authors and diagnosed as immune-mediated neuropathy were analyzed for etiology, pathology, and outcome assessed...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456210/appraising-the-outcome-and-complications-of-peritoneal-dialysis-patients-in-self-care-peritoneal-dialysis-and-assisted-peritoneal-dialysis-a-5-year-review-of-a-single-saudi-center
#20
Jamal Saleh Al Wakeel, Mohammed A Al Ghonaim, Abdullah Aldohayan, Saira Usama, Saad Al Obaili, Ahmad R Tarakji, Mohammad Alkhowaiter
Our objective is to study the outcomes and complications of peritoneal dialysis (PD) including comparison of self-care PD with home-care assisted PD during a five-year period. A retrospective study of PD data at King Saud University-affiliated hospital in Riyadh from January 1, 2009, to December 31, 2013. One hundred and eleven patients were included (female 55%). The average age was 47.4 (1-83) years. Twenty-one (18.91%) patients were on continuous ambulatory PD and 90 (81.08%) on automated PD. The mean time on PD was 23...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
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