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https://www.readbyqxmd.com/read/29351070/a-serological-study-of-antibodies-to-anaplasma-phagocytophilum-and-borrelia-burgdorferi-sensu-lato-in-the-sera-of-healthy-individuals-collected-two-decades-apart
#1
Bohumír Kříž, Marek Malý, Pavla Balátová, Petr Kodym, Zuzana Kurzová, Milan Daniel, Kateřina Kybicová
Sera collected from healthy individuals from the general population in the Czech Republic during repeated cross-sectional surveys were analyzed. Samples collected in the same six districts in two time periods, 1978-1989 and 2001, were compared. The study subjects were divided into six age categories between 10 and 59 years. Overall, 434 samples from 1978-1989 and 270 samples from 2001 were screened for Anaplasma phagocytophilum (AP) and Borrelia burgdorferi sensu lato (BB). The anti-AP positivity rates were 13...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29349279/parental-population-exposure-to-historical-socioeconomic-and-political-periods-and-grand-child-s-birth-weight-in-the-lifeways-cross-generation-cohort-study-in-the-republic-of-ireland
#2
Cilia Mejia-Lancheros, John Mehegan, Ricardo Segurado, Celine Murrin, Cecily Kelleher
Exposure to deprived socioeconomic conditions during the peri-conception and early childhood periods can have a negative long-term impact on individuals' health and that of their progeny. We aimed to examine whether relatives' birth period affected index-child (grand-child) birthweight status in the Lifeways Cross-Generation Cohort in the Republic of Ireland. Participants were 943 mothers and offspring, 890 fathers, 938 maternal grandmothers (MGM), 700 maternal grandfathers (MGF) 537 paternal grandmothers (PGM) and 553 paternal grandfathers (PGF)...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29348469/treprostinil-inhibits-proliferation-and-extracellular-matrix-deposition-by-fibroblasts-through-camp-activation
#3
Christopher Lambers, Michael Roth, Peter Jaksch, Gabriella Muraközy, Michael Tamm, Walter Klepetko, Bahil Ghanim, Feng Zhao
Idiopathic pulmonary fibrosis (IPF) is characterized by peripheral lung fibrosis and increased interstitial extracellular matrix (ECM) deposition. In IPF, tumor growth factor (TGF)-β1 which is the major stimulus of ECM deposition, and platelet derived growth factor (PDGF)-BB is a potent stimulus of fibrosis. Thus, the effect of Treprostinil on TGF-ß1 and PDGF-induced fibroblast proliferation and ECM deposition was investigated. Human peripheral lung fibroblasts of seven IPF patients and five lung donors were stimulated by PDGF, or TGF-β1, or the combination...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341933/the-effects-of-platelet-lysate-patches-on-the-activity-of-tendon-derived-cells
#4
Raquel Costa-Almeida, Albina R Franco, Tamagno Pesqueira, Mariana B Oliveira, Pedro S Babo, Isabel B Leonor, João F Mano, Rui L Reis, Manuela E Gomes
Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeutic factors in patch augmentation strategies aiming at tendon repair. Developed PL patches exhibited a controlled release profile of PL proteins, including bFGF and PDGF-BB...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29341591/the-development-of-benzimidazole-based-clickable-probes-for-the-efficient-labeling-of-cellular-protein-arginine-deiminases-pads
#5
Venkatesh J Nemmara, Venkataraman Subramanian, Aaron Muth, Santanu Mondal, Ari J Salinger, Aaron J Maurais, Ronak Tilvawala, Eranthie Weerapana, Paul R Thompson
Citrullination is the post-translational hydrolysis of peptidyl-arginines to form peptidyl-citrulline, a reaction that is catalyzed by the protein arginine deiminases (PADs), a family of calcium-regulated enzymes. Aberrantly increased protein citrullination is associated with a slew of autoimmune diseases (e.g., rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis) and certain cancers. Given the clear link between increased PAD activity and human disease, the PADs are therapeutically relevant targets...
January 17, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29339431/molecular-insights-into-function-and-competitive-inhibition-of-pseudomonas-aeruginosa-multiple-virulence-factor-regulator
#6
Tomoe Kitao, Francois Lepine, Seda Babloudi, Frederick Walte, Stefan Steinbacher, Klaus Maskos, Michael Blaesse, Michele Negri, Michael Pucci, Bob Zahler, Antonio Felici, Laurence G Rahme
New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria. Multiple virulence factor regulator (MvfR or PqsR), a Pseudomonas aeruginosa quorum sensing transcription factor, regulates functions important in both acute and persistent infections. Recently identified non-ligand-based benzamine-benzimidazole (BB) inhibitors of MvfR suppress both acute and persistent P. aeruginosa infections in mice without perturbing bacterial growth...
January 16, 2018: MBio
https://www.readbyqxmd.com/read/29332578/amyloid-%C3%AE-inhibits-pdgf%C3%AE-receptor-activation-and-prevents-pdgf-bb-induced-neuroprotection
#7
Hui Liu, Golam T Saffi, Maryam S Vasefi, Youngjik Choi, Jeff S Kruk, Nawaz Ahmed, Nyasha Gondora, John Mielke, Zoya Leonenko, Michael A Beazely
PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective against excitotoxicity and HIV proteins. METHODS: Given this growth factor's neuroprotective ability, we sought to determine if PDGF-BB would be neuroprotective against amyloid-β (1-42), one of the pathological agents associated with Alzheimer's disease (AD). In both primary hippocampal neurons and the human-derived neuroblastoma cell line, SH-SY5Y, amyloid- treatment for 24 h decreased surviving cell number in a concentration-dependent manner...
January 9, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29331126/binding-branched-and-linear-dna-structures-from-isolated-clusters-to-fully-bonded-gels
#8
J Fernandez-Castanon, F Bomboi, F Sciortino
The proper design of DNA sequences allows for the formation of well-defined supramolecular units with controlled interactions via a consecution of self-assembling processes. Here, we benefit from the controlled DNA self-assembly to experimentally realize particles with well-defined valence, namely, tetravalent nanostars (A) and bivalent chains (B). We specifically focus on the case in which A particles can only bind to B particles, via appropriately designed sticky-end sequences. Hence AA and BB bonds are not allowed...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29327824/are-there-bilateral-isokinetic-shoulder-rotator-differences-in-basketball-male-players
#9
Thierry Weissland, Maryne Cozette, Clare Doyle, Antoine Gabrion
BACKGROUND: The internal (IR) and external (ER) rotator shoulder strength are often assess in the upper limb sports to prevent a risk of injuries. The purpose of this comparative study was to measure the agonist/antagonist balance of shoulder strength and to determine whether significant differences exist between the dominant and nondominant sides in basketball players compared to a control groups. METHODS: During the championship, 23 elite male-basketball players (BB) and 23 healthy males (CG) were tested bilaterally on a Cybex Norm isokinetic dynamometer in a seated position with 45° shoulder abduction in the scapular plane at 60°...
January 10, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29327677/autologous-smooth-muscle-progenitor-cells-enhance-regeneration-of-tissue-engineered-bladder
#10
Liuhua Zhou, Jiadong Xia, Pengji Wang, Ruipeng Jia, Jun Hua Zheng, Xudong Yao, Yun Chen, Yutian Dai, Bin Yang
Tissue engineering techniques provide a great potential to de novo construct a histological bladder. Smooth muscle regeneration is extremely important for the functional recovery of engineered neo-bladder. However, many challenges remain for the use of bladder smooth muscle cells (SMCs) as the cell sources. Recent evidences showed that smooth muscle progenitor cells (SPCs) in the peripheral blood have the capacity of differentiating into SMCs, while their use for bladder regeneration hasn't yet been reported...
January 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29322347/all-aspect-of-toxic-effect-of-brilliant-blue-and-sunset-yellow-in-allium-cepa-roots
#11
Kemal Koç, Dilek Pandir
Substances added to food are considerable for survival and are the oldest technologies used in preservation, sweetening and coloring. This work was conducted to evaluate the toxicity of the food additives sunset yellow (SY) and brilliant blue (BB) on Allium cepa root meristematic cells. Control and treatment groups were created from germinated roots. Group 1 (control group) did not receive chemicals. Group 2 (SY or BB-treatment group), received increasing doses of SY (25, 50, 100 and 500 ppm) and BB (100, 200, 400 and 500 ppm) with time periods of 24, 48 and 72 h...
January 10, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29319525/physiological-effects-of-whey-and-milk-based-probiotic-yogurt-in-rats
#12
Judit Szabó-Fodor, András Bónai, Brigitta Bóta, Linda Szommerné Egyed, Ferenc Lakatos, Gréta Pápai, Attila Zsolnai, Róbert Glávits, Katalin Horvatovich, Melinda Kovács
In an in vitro experiment commercially available probiotic products were tested for the survival of bacteria under conditions of simulated human digestion either when used alone or mixed into yogurt. In the in vivo experiment the effects of feeding a whey- and milk-based yogurt prepared with the probiotic strain showing adequate survival in the in vitro experiment, was measured on body weight, feed con¬sumption and immune response of rats (IgG and IgA level after immunisation), on the composition and volatile fatty acid production of the intestinal microbiota and on the structure of intestinal villi...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29319128/the-preliminary-study-on-expression-and-clinical-value-of-platelet-derived-growth-factor-bb-hypoxia-inducible-factor-1%C3%AE-and-c-c-motif-chemokine-receptor-2-in-the-peripheral-blood-during-the-pathogenesis-of-graves-disease
#13
Ying Liu, Jinglan Tang, Qiaohong Hu, Kefeng Lu, Chunjie Hou
Backgroud: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD(Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, Hypoxia inducible factor(HIF)-1α and C-C motif chemokine receptor(CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. METHODS: 41 patients with GD (GD group) and 45 healthy people(control group) were chosen...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29318632/reflexivity-without-identity-matching-training-a-first-demonstration
#14
Melissa Swisher, Peter J Urcuioli
Until now, the equivalence property of reflexivity-matching physically identical stimuli to themselves after training on a set of arbitrary matching relations-has not been demonstrated in any animal, human or nonhuman. Previous reports of reflexivity have either implicitly or explicitly involved reinforced training on other identity matching relations. Here we demonstrate reflexivity without prior identity matching training. Pigeons received concurrent successive matching training on three arbitrary matching tasks: AB (hue-form), BC (form-hue), and AC (hue-hue with different hues in the A and C sets)...
January 10, 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29306781/mechanisms-of-biochar-reducing-the-bioaccumulation-of-pahs-in-rice-from-soil-degradation-stimulation-vs-immobilization
#15
Ni Ni, Fang Wang, Yang Song, Yongrong Bian, Renyong Shi, Xinglun Yang, Chenggang Gu, Xin Jiang
This study aimed to elucidate the mechanisms by which biochar reduces the bioaccumulation of polycyclic aromatic hydrocarbons (PAHs) in rice under anaerobic conditions. Corn straw- or bamboo-derived biochar pyrolyzed at 300 °C and 700 °C (CB300 or BB700), respectively, was amended into flooded PAH-contaminated soil. After harvest, 2% CB300, 0.5% BB700 or 2% BB700 amendments reduced the bioaccumulation of PAHs in rice root, especially that of high-molecular-weight PAHs (p < .05). Total PAH concentrations were higher, and their bioavailable concentrations were lower in BB700-amended soils than the control...
January 2, 2018: Chemosphere
https://www.readbyqxmd.com/read/29304059/space-use-by-4-strains-of-laying-hens-to-perch-wing-flap-dust-bathe-stand-and-lie-down
#16
Elizabeth R Riddle, Ahmed B A Ali, Dana L M Campbell, Janice M Siegford
The laying hen industry is implementing aviary systems intended to improve welfare by providing hens with more space and resources to perform species-specific behaviors. To date, limited research has examined spatial requirements of various strains of laying hens for performing key behaviors and none has been conducted within an alternative housing system. This study investigated the amount of space used by 4 strains of laying hens (Hy-Line Brown [HB], Bovans Brown [BB], DeKalb White [DW], and Hy-Line W36) to perform 5 different behaviors in the litter area of a commercial-style aviary...
2018: PloS One
https://www.readbyqxmd.com/read/29298329/molecular-and-functional-analysis-of-anchorage-independent-treatment-evasive-neuroblastoma-tumorspheres-with-enhanced-malignant-properties-a-possible-explanation-for-radio-therapy-resistance
#17
Tamara J Abou-Antoun, Javad Nazarian, Anthony Ghanem, Stanislav Vukmanovic, Anthony D Sandler
Despite significant advances in cancer treatment and management, more than 60% of patients with neuroblastoma present with very poor prognosis in the form of metastatic and aggressive disease. Solid tumors including neuroblastoma are thought to be heterogeneous with a sub-population of stem-like cells that are treatment-evasive with highly malignant characteristics. We previously identified a phenomenon of reversible adaptive plasticity (RAP) between anchorage dependent (AD) cells and anchorage independent (AI) tumorspheres in neuroblastoma cell cultures...
2018: PloS One
https://www.readbyqxmd.com/read/29297161/proteolytic-extracts-of-three-bromeliaceae-species-as-eco-compatible-tools-for-leather-industry
#18
María Eugenia Errasti, Néstor Oscar Caffini, Laura María Isabel López
Most tanneries use high proportions of Na2S and CaO during the dehairing step, resulting in effluents of high alkalinity and large amounts of suspended solid, besides the risk of liberating the toxic H2S. Solid waste rich in protein is another environmental problem of tanneries. Enzymes are an interesting technological tool for industry due to their biodegradability, nontoxic nature, and nonpolluting effluent generation. In the leather industry, proteases have been chosen as a promising eco-friendly alternative to Na2S/CaO dehairing...
January 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29287227/bladder-wall-biomechanics-a-comprehensive-study-on-fresh-porcine-urinary-bladder
#19
Maryam Sami Jokandan, Fatemeh Ajalloueian, Magnus Edinger, Peter Reimer Stubbe, Stefania Baldursdottir, Ioannis S Chronakis
Regenerative medicine for reconstructive urogenital surgery has been widely studied during the last two decades. One of the key factors affecting the quality of bladder regeneration is the mechanical properties of the bladder scaffold. Insight into the biomechanics of this organ is expected to assist researchers with functional regeneration of the bladder wall. Due to extensive similarities between human bladder and porcine bladder, and with regard to lack of comprehensive biomechanical data from the porcine bladder wall (BW), our main goal here was to provide a thorough evaluation on viscoelastic properties of fresh porcine urinary BW...
November 28, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29283057/advanced-strategies-in-the-diagnosis-and-treatment-of-patients-with-coronary-artery-disease-and-heart-failure-when-heart-failure-causes-ischemia-and-angiotensin-converting-enzyme-inhibitor-and-betablockers-helps-in-diuresis
#20
Thach Nguyen, Nguyen Van Lanh, Vo Minh Viet, Lam Hoang Phuc, Trung N Pham, Khanh Duong, Luke Ashwin Lawrence, Vien T Truong, Gianluca Rigatelli
In the diagnosis and management of patients with coronary artery disease (CAD) and chronic left ventricular (LV) dysfunction or heart failure (HF), there are many uncertainties because of the non-specificity of the symptoms and signs of HF. Usually, severe CAD causes LV dysfunction. However, not rarely, LV dysfunction is the cause or aggravation of ischemia to many subsets of patients with or without CAD. In this article, the care of patients with CAD with LV dysfunction, along with the challenges of diagnosing asymptomatic HF and the criteria for monitoring success are presented...
December 27, 2017: Current Pharmaceutical Design
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