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Lung cryobiopsy

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https://www.readbyqxmd.com/read/29394172/the-emerging-spectrum-of-exposure-related-bronchiolitis
#1
Silpa D Krefft, Carlyne D Cool, Cecile S Rose
PURPOSE OF REVIEW: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations and a spectrum of histopathologic abnormalities affecting the small airways. This review provides an overview of the histologic patterns and occupational settings for exposure-related bronchiolitis, along with recent advances in disease diagnosis and management. RECENT FINDINGS: The entire histopathologic spectrum of bronchiolitis (constrictive, obliterative, proliferative, lymphocytic, respiratory) has been reported in exposure-related bronchiolitis...
February 1, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29321931/novel-hybrid-cryo-radial-method-an-emerging-alternative-to-ct-guided-biopsy-in-suspected-lung-cancer-a-prospective-case-series-and-description-of-technique
#2
Samantha Herath, Elaine Yap
In diagnosing peripheral pulmonary lesions (PPL), radial endobronchial ultrasound (R-EBUS) is emerging as a safer method in comparison to CT-guided biopsy. Despite the better safety profile, the yield of R-EBUS remains lower (73%) than CT-guided biopsy (90%) due to the smaller size of samples. We adopted a hybrid method by adding cryobiopsy via the R-EBUS Guide Sheath (GS) to produce larger, non-crushed samples to improve diagnostic capability and enhance molecular testing. We report six prospective patients who underwent this procedure in our institution...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29316560/transbronchial-cryobiopsies-for-the-diagnosis-of-diffuse-parenchymal-lung-diseases-expert-statement-from-the-cryobiopsy-working-group-on-safety-and-utility-and-a-call-for-standardization-of-the-procedure
#3
Jürgen Hetzel, Fabien Maldonado, Claudia Ravaglia, Athol U Wells, Thomas V Colby, Sara Tomassetti, Jay H Ryu, Oren Fruchter, Sara Piciucchi, Alessandra Dubini, Alberto Cavazza, Marco Chilosi, Nicola Sverzellati, Dominique Valeyre, Dimitri Leduc, Simon L F Walsh, Stefano Gasparini, Martin Hetzel, Lars Hagmeyer, Maik Haentschel, Ralf Eberhardt, Kaid Darwiche, Lonny B Yarmus, Alfonso Torrego, Ganesh Krishna, Pallav L Shah, Jouke T Annema, Felix J F Herth, Venerino Poletti
Transbronchial cryobiopsies (TBCB) have recently been introduced as a promising and safer alternative to surgical lung biopsy in the diagnostic approach to diffuse parenchymal lung diseases (DPLD). Despite a substantial and expanding body of literature, the technique has not yet been standardized and its place in the diagnostic algorithm of DPLD remains to be defined. In part, this reflects concerns over the diagnostic yield and safety of the procedure, together with the rapid spread of the technique without competency and safety standards; furthermore, there is a substantial procedural variability among centers and interventional pulmonologists...
January 9, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29275603/-efficacy-and-safety-of-transbronchial-cryobiopsy-in-the-etiologic-diagnosis-of-diffuse-lung-disease
#4
Y S Li, S L Guo, X H Yi, M L Xiao, X X Jin, Y Xiao, X Y Zhu, X Li, L W Dai, Z Ao, X Z Liu, M Ding
Objective: To assess the efficacy and safety of transbronchial cryobiopsy (TBCB) for the etiologic evaluation of diffuse lung disease (DLD). Methods: Between December 2015 to April 2017, a total of 38 patients with DLD met the inclusion criteria for TBCB in the First Affiliated Hospital of Chongqing Medical University, and 35 of them consented to undergo the procedure under rigid or flexible bronchoscopy. On the tissues obtained from the 35 patients, histopathologic and microbiological evaluations were performed, and together with clinical and radiological manifestations, diagnoses were made and the efficacy of TBCB in the diagnosis of DLD was confirmed, and then therapies were planned accordingly...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29261589/transbronchial-lung-cryobiopsy-with-2-bronchoscopes-nec-novum-nec-magna
#5
Sahajal Dhooria, Inderpaul S Sehgal, Kuruswamy T Prasad, Ritesh Agarwal
No abstract text is available yet for this article.
January 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29214060/interstitial-lung-disease-the-diagnostic-role-of-bronchoscopy
#6
REVIEW
Jad Kebbe, Tony Abdo
Interstitial lung diseases (ILDs) form one of the most fascinating fields in pulmonary medicine. They also pose one of the greatest challenges for accurate diagnosis and proper treatment. Even within the recommended and warranted multidisciplinary approach, differentiating between one disease and another may lead to frustration, especially when proper lung tissue is not available for adequate pathological review. A surgical lung biopsy (SLB) might render enough tissue for histopathology, but this could come at the expense of high morbidity and even mortality, as in the case of usual interstitial pneumonia (UIP)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29174087/learning-curve-for-transbronchial-lung-cryobiopsy-in-diffuse-lung-disease
#7
L M Almeida, B Lima, P C Mota, N Melo, A Magalhães, J M Pereira, C S Moura, S Guimarães, A Morais
INTRODUCTION: Transbronchial lung cryobiopsy (TBLC) is increasingly used in the diagnosis of diffuse lung disease (DLD), but no data have yet been published on the learning curve associated with this technique. AIM: To evaluate diagnostic yield, lung tissue sample length and area, and procedure-related complications in a cohort of TBLC procedures to define the learning curve and threshold for proficiency. METHODS: Retrospective analysis of the first 100 TBLCs performed in different segments of the same lobe in patients with suspected DLD...
November 22, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29139354/-idiopathic-pulmonary-fibrosis-is-an-overlooked-disease
#8
EDITORIAL
Elisabeth Bendstrup, Sissel Kronborg-White, Thomas Skovhus Prior, Janne Møller, Charlotte Hyldgaard
Idiopathic pulmonary fibrosis is a chronic, progressive and fatal disease which primarily occurs in male patients over 60 years with a smoking history. Cryobiopsy is a new promising method for obtaining lung tissue for histologic analysis with fewer complications than surgical lung biopsy. Cryobiopsy allows more patients to be diagnosed. Antifibrotic treatment has shown to decrease progression and prolong survival time in both early and later stages of the disease. Early diagnosis and treatment are therefore of great importance to prevent disease progression and reduce mortality...
November 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29105361/a-multicenter-study-on-the-safety-and-efficacy-of-different-methods-for-obtaining-transbronchial-lung-cryobiopsy-in-diffuse-lung-diseases
#9
Sahajal Dhooria, Ravindra Mehta, Arjun Srinivasan, Karan Madan, Inderpaul Singh Sehgal, Vallandramam Pattabhiraman, Pavan Yadav, Mahadevan Sivaramakrishnan, Anant Mohan, Amanjit Bal, Mandeep Garg, Ritesh Agarwal
INTRODUCTION: Most data on transbronchial lung cryobiopsy (TBLC) are from single centers, with little evidence on the outcome of different methods for performing TBLC. OBJECTIVE: To report the diagnostic yield and safety of TBLC with different procedural techniques. METHODS: Retrospective multicenter study of subjects who underwent TBLC for the diagnosis of diffuse parenchymal lung diseases (DPLDs). The procedure was performed using various methods: flexible or rigid bronchoscopy, with or without the use of fluoroscopy or occlusion balloon...
November 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29050527/how-might-transbronchial-cryobiopsy-improve-diagnosis-and-treatment-of-diffuse-parenchymal-lung-disease-patients
#10
Venerino Poletti, Claudia Ravaglia, Alessandra Dubini, Sara Piciucchi, Giulio Rossi, Sissel Kronborg-White, Sara Tomassetti
No abstract text is available yet for this article.
October 25, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29021953/bilateral-lung-disease-extensive-and-diffuse-diagnosis-of-pulmonary-alveolar-proteinosis-by-bronchoscopic-cryobiopsy
#11
Sebastián Gando, Roberto Duré, Damián Violi, Bibiana Vazquez, Gonzalo Labarca, Sebastián Fernandez-Bussy
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the intra-alveolar accumulation of a proteinaceous phospholipid-laden material called surfactant. Clinically, this disease should be suspected with respiratory failure in association with a crazy paving pattern on high-resolution chest computed tomography. We report a 24-year-old gentleman who was referred to us for a history of respiratory failure, treatment with invasive ventilation and tracheostomy. His blood exams and biochemistry were normal...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28947045/the-complimentary-role-of-transbronchial-lung-cryobiopsy-and-endobronchial-ultrasound-fine-needle-aspiration-in-the-diagnosis-of-sarcoidosis
#12
Alejandro Adolfo Aragaki-Nakahodo, Robert P Baughman, Ralph T Shipley, Sadia Benzaquen
PURPOSE: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved to be useful in diagnosing various interstitial lung diseases (ILD). The use of TBLC to diagnose sarcoidosis in an unselected patient population is unknown, and could be complimentary to endobronchial ultrasound fine needle aspiration (EBUS-FNA). METHODS: A retrospective analysis of 36 patients in a single, tertiary-care, academic medical center was conducted to describe the yield of both EBUS-FNA and TBLC in the diagnosis of suspected sarcoidosis over a three year period...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28869942/pulmonary-cavities-after-diagnostic-transbronchial-cryobiopsy-in-a-lung-transplantation-patient
#13
Rebeca Sicilia Torres, Felipe Rodríguez de Castro, Carlos Cabrera López, Gabriel Juliá Serdá, Fernando Rezola Sáez, Rubén Pestana
No abstract text is available yet for this article.
September 5, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28840020/transbronchial-cryobiopsy-for-diffuse-parenchymal-lung-disease-a-state-of-the-art-review-of-procedural-techniques-current-evidence-and-future-challenges
#14
REVIEW
Robert J Lentz, A Christine Argento, Thomas V Colby, Otis B Rickman, Fabien Maldonado
Transbronchial lung biopsy with a cryoprobe, or cryobiopsy, is a promising new bronchoscopic biopsy technique capable of obtaining larger and better-preserved samples than previously possible using traditional biopsy forceps. Over two dozen case series and several small randomized trials are now available describing experiences with this technique, largely for the diagnosis of diffuse parenchymal lung disease (DPLD), in which the reported diagnostic yield is typically 70% to 80%. Cryobiopsy technique varies widely between centers and this predominantly single center-based retrospective literature heterogeneously defines diagnostic yield and complications, limiting the degree to which this technique can be compared between centers or to surgical lung biopsy (SLB)...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28800991/supraglottic-airway-device-for-transbronchial-lung-cryobiopsy
#15
EDITORIAL
Theresa A Gelzinis
No abstract text is available yet for this article.
August 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28800873/transbronchial-lung-cryobiopsy-associated-complications
#16
R Linhas, R Marçôa, A Oliveira, J Almeida, S Neves, S Campainha
INTRODUCTION: Transbronchial lung cryobiopsy (TBC) has emerged as a diagnostic alternative to surgical lung biopsy in interstitial lung disease (ILD). Despite its less invasive nature, some associated complications have been described. OBJECTIVE: To evaluate complications of TBC and associated factors. METHODS: Prospective evaluation of all patients with ILD submitted to TBC in our centre. Clinicodemographic variables and factors associated to TBC complications were analyzed...
August 8, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28796717/utility-of-flexible-bronchoscopic-cryobiopsy-for-diagnosis-of-diffuse-parenchymal-lung-diseases
#17
Robert J Lentz, Trevor M Taylor, Jonathan A Kropski, Kim L Sandler, Joyce E Johnson, Timothy S Blackwell, Fabien Maldonado, Otis B Rickman
BACKGROUND: Initial reports of transbronchial cryobiopsy for diffuse parenchymal lung disease (DPLD) suggest the diagnostic yield approaches that of surgical lung biopsy (SLB) with an excellent safety profile. Centers performing cryobiopsy differ significantly in procedure technique; an optimal technique minimizing complications but still capable of diagnosing a wide range of DPLDs has not been established. We evaluated our practice of flexible bronchoscopic cryobiopsy in a primarily outpatient setting for patients who required a tissue diagnosis for DPLD of uncertain etiology...
August 7, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28794143/differential-diagnosis-of-granulomatous-lung-disease-clues-and-pitfalls-number-4-in-the-series-pathology-for-the-clinician-edited-by-peter-dorfm%C3%A3-ller-and-alberto-cavazza
#18
Shinichiro Ohshimo, Josune Guzman, Ulrich Costabel, Francesco Bonella
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis)...
September 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28752492/pulmonary-involvement-in-systemic-vasculitis
#19
REVIEW
Luis Felipe Flores-Suárez, Marco A Alba, Heidegger Mateos-Toledo, Natllely Ruiz
PURPOSE OF REVIEW: The purpose of this study is to describe the most relevant advances concerning lung involvement in the ANCA-associated vasculitides (excluding eosinophilic granulomatosis with polyangiitis which may have different disease mechanisms). Focus is on pathophysiology, recent important imagenological procedures, treatment, and outcome. RECENT FINDINGS: Emerging information exists on potential newly investigated diagnostic procedures (v.g. transbronchial cryobiopsies), detailed tomographic abnormalities, the potential favorable role of rituximab and the still uncertain one of plasma exchange in the treatment, and the increasing description of interstitial lung disease...
September 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28743122/utility-of-transbronchial-lung-cryobiopsy-in-non-interstitial-diseases
#20
Olivia Sánchez-Cabral, Dina Martínez-Mendoza, Sebastián Fernandez-Bussy, Berenice López-González, Carolina Perea-Talamantes, Rosa María Rivera-Rosales, César Luna-Rivero, José Arturo Martínez-Orozco, Luis Felipe Flores-Suárez, Patricio Santillán-Doherty, Gustavo Reyes-Terán
BACKGROUND: Transbronchial lung cryobiopsy (TLCB), performed with a flexible cryoprobe, is an interventional pulmonology procedure that has proved its diagnostic value for interstitial pulmonary disease. However, it has not been explored extensively as a diagnostic tool for patients with non-interstitial lung pathology, including infectious and malignant diseases. OBJECTIVE: To evaluate the diagnostic yield and safety of an interventional pulmonology approach that integrates TLCB and bronchoalveolar lavage (BAL) for the diagnosis of non-interstitial pulmonary disease...
2017: Respiration; International Review of Thoracic Diseases
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