Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D Barwick, Kevin O'Neill, James Wang, Azeem Saleem, James O'Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman, Eric O Aboagye
PURPOSE: MRI and PET are used in neuro-oncology for the detection and characterisation of lesions for malignancy to target surgical biopsy and to plan surgical resections or stereotactic radiosurgery. The critical role of short-chain fatty acids (SCFAs) in brain tumour biology has come to the forefront. The non-metabolised SCFA radiotracer, [18 F]fluoropivalate (FPIA), shows low background signal in most tissues except eliminating organs and has appropriate human dosimetry. Tumour uptake of the radiotracer is, however, unknown...
July 25, 2023: European Journal of Nuclear Medicine and Molecular Imaging