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https://www.readbyqxmd.com/read/27902383/detection-of-isaba1-in-association-with-a-novel-allelic-variant-of-the-%C3%AE-lactamase-adc-82-and-class-d-%C3%AE-lactamase-genes-mediating-carbapenem-resistance-among-the-clinical-isolates-of-mdr-a-baumannii
#1
Rajagopalan Saranathan, Rinki Kumari, Ramakrishnan Kalaivani, Sah Suresh, Anshu Rani, Shashikala Purty, Prashanth K
The objective of the present study is to investigate the diverse resistance determinants, their association with IS mobile elements and predilection of a particular clone for such associations in A. baumannii. Fifty-four consecutive isolates collected during 2011-2012 from a tertiary care hospital were subjected to susceptibility testing followed by PCR screening of commonly reported β-lactamases and 16S rRNA methyl transferase encoding genes. The integrity of RND efflux pump related genes in their respective operons was also investigated...
November 25, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27879336/beyond-antimicrobial-resistance-evidence-for-a-distinct-role-of-the-acrd-efflux-pump-in-salmonella-biology
#2
Michelle M C Buckner, Jessica M A Blair, Roberto M La Ragione, Jane Newcombe, Daniel J Dwyer, Alasdair Ivens, Laura J V Piddock
: For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment conditions, and why have multiple pumps if their only purpose is antimicrobial efflux? Salmonella spp. possess five efflux pump families, including the resistance-nodulation-division (RND) efflux pumps. Notably, the RND efflux pump AcrD has a unique substrate profile, distinct from other Salmonella efflux pumps...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27828639/acrokeratosis-verruciformis-of-hopf-case-report
#3
Tatiana Cristina Pedro Cordeiro de Andrade, Gardênia Viana da Silva, Tatiane Meira Pinho Silva, Ana Cecília Versiani Duarte Pinto, Adauto José Ferreira Nunes, Antônio Carlos Ceribelli Martelli
A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After three days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27825482/unraveling-genomic-and-phenotypic-nature-of-multidrug-resistant-mdr-pseudomonas-aeruginosa-vrfpa04-isolated-from-keratitis-patient
#4
Murugan N, Malathi J, Umashankar V, Madhavan H N
Multidrug-resistant (MDR) Pseudomonas aeruginosa VRFPA04, obtained from a keratitis patient was found to exhibit resistance to betalactam (Penicillins, cephalosporins, including carbapenems, except aztreonam), aminoglycosides, quinolone group of drugs and susceptible to colistin. The complete genome sequencing of the ocular isolate to measure and ascertain the degree of multidrug resistance in VRFPA04 strain resulted in 6,818,030bp (6.8Mb) genome sizes, which happen to be the third largest genome available in the Genbank to date...
December 2016: Microbiological Research
https://www.readbyqxmd.com/read/27815276/genome-dynamics-and-molecular-infection-epidemiology-of-multi-drug-resistant-helicobacter-pullorum-isolates-obtained-from-broiler-and-country-chickens-in-india
#5
Shamsul Qumar, Mohammad Majid, Narender Kumar, Sumeet K Tiwari, Torsten Semmler, Savita Devi, Ramani Baddam, Arif Hussain, Sabiha Shaik, Niyaz Ahmed
: Some of the life-threatening, foodborne, and zoonotic infections are transmitted through poultry birds. Inappropriate and indiscriminate use of antimicrobials in livestock industry has led to increased prevalence of multidrug resistant bacteria of epidemic potentials. Herein, we present the functional molecular epidemiological analysis entailing phenotypic as well as whole genome sequence based characterization of eleven H. pullorum isolates from broiler and free range chickens sampled from retail wet markets of Hyderabad city in India...
November 4, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27806930/rnd-efflux-pump-and-its-interrelationship-with-quorum-sensing-system
#6
Liang Zhibin, Chen Yumei, Chen Yufan, Cheng Yingying, Zhang Lianhui
Antibiotic resistance has become a serious concern in treatment of bacterial infections. Overexpression of efflux pump is one of the important mechanisms in antibiotic resistance. In Gram negative bacteria, RND (Resistance-nodulation-cell division) superfamily efflux pump plays a vital important role in antibiotics resistance. Recent research progress unveils an intriguing interrelationship between RND efflux pump and the bacterial quorum sensing system, whose regulation is dependent on small signal molecules...
October 20, 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27789287/effect-of-site-directed-mutations-in-multidrug-efflux-pump-acrb-examined-by-quantitative-efflux-assays
#7
Alfred D Kinana, Attilio V Vargiu, Hiroshi Nikaido
BACKGROUND: The Resistance-Nodulation-Division (RND) family transporter AcrB plays a major role in the intrinsic and increased resistance of Escherichia coli to a large number of antibiotics. The distal binding pocket within this multidrug efflux transporter is very large, but the effort to define the roles of various residues facing this pocket through site-directed mutagenesis so far involved only the determination of minimal inhibitory concentrations of drugs in mutants. METHODS: We measured in intact E...
November 25, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27776222/neck-dissection-s-burden-on-the-patient-functional-and-psychosocial-aspects-in-1-652-patients-with-oral-squamous-cell-carcinomas
#8
Simon Spalthoff, Rüdiger Zimmerer, Philipp Jehn, Nils-Claudius Gellrich, Jörg Handschel, Gertrud Krüskemper
PURPOSE: In this study of patients with oral squamous cell carcinoma, the authors sought to clarify the functional and psychosocial harms of neck dissection (ND), which lessens quality of life. MATERIALS AND METHODS: The study included questionnaire responses from patients with oral squamous cell carcinoma (n = 1,652) and clinicians (n = 1,489), as collected in the DÖSAK Rehab Study. Psychosocial and functional factors were assessed. Functional and psychosocial outcomes in patients who did not receive ND were compared with those in patients who underwent selective supraomohyoid ND (SND), modified radical ND (MND), and radical ND (RND)...
September 28, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27764576/multidrug-efflux-pumps-and-their-role-in-antibiotic-and-antiseptic-resistance-a-pharmacodynamic-perspective
#9
Sandrine Alibert, Joannah N'Gompazza Diarra, Jessica Hernandez, Aurélien Stutzmann, Marwa Fouad, Gérard Boyer, Jean-Marie Pagès
Worrying levels of bacterial resistance have been reported worldwide involving the failure of many available antibiotic treatments. Multidrug resistance (MDR) in Gram-negative bacteria is often ascribed to the presence of multiple and different resistance mechanisms in the same strain. RND efflux pumps play a major role and are an attractive target to discover new antibacterial drugs. Areas covered: This review discusses the prevalence of efflux pumps, their overexpression in clinical scenarios, their polyselectivity, their effect on the intracellular concentrations of various antibiotics associated with the alteration of the membrane permeability and their involvement in pathogenicity are discussed...
October 20, 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27762102/multiple-roles-for-a-novel-rnd-type-efflux-system-in-acinetobacter-baumannii-ab5075
#10
Kyle A Tipton, Marjan Farokhyfar, Philip N Rather
Colony opacity phase variation in Acinetobacter baumannii strain AB5075 is regulated by a reversible high-frequency switch. Transposon mutagenesis was used to generate mutations that decreased the opaque to translucent switch and a gene encoding a predicted periplasmic membrane fusion component of a resistance-nodulation-cell division (RND)-type efflux system was isolated. This gene was designated arpA and immediately downstream was a gene designated arpB that encodes a predicted membrane transporter of RND-type systems...
October 19, 2016: MicrobiologyOpen
https://www.readbyqxmd.com/read/27736975/cpxr-activates-mexab-oprm-efflux-pump-expression-and-enhances-antibiotic-resistance-in-both-laboratory-and-clinical-nalb-type-isolates-of-pseudomonas-aeruginosa
#11
Zhe-Xian Tian, Xue-Xian Yi, Anna Cho, Fergal O'Gara, Yi-Ping Wang
Resistance-Nodulation-Division (RND) efflux pumps are responsible for multidrug resistance in Pseudomonas aeruginosa. In this study, we demonstrate that CpxR, previously identified as a regulator of the cell envelope stress response in Escherichia coli, is directly involved in activation of expression of RND efflux pump MexAB-OprM in P. aeruginosa. A conserved CpxR binding site was identified upstream of the mexA promoter in all genome-sequenced P. aeruginosa strains. CpxR is required to enhance mexAB-oprM expression and drug resistance, in the absence of repressor MexR, in P...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27647971/radical-nerve-dissection-for-the-carcinoma-of-head-of-pancreas-report-of-30-cases
#12
Qing Lin, Langping Tan, Yu Zhou, Quanbo Zhou, Rufu Chen
OBJECTIVE: To explore the clinical value of the radical nerve dissection (RND) for the carcinoma of head of pancreas (CHP). METHODS: The clinical and pathological data of 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to explore the safety and short-term efficacy of this procedure. RESULTS: Among these 30 patients, the operative time was (351±61) min, the intra-operative blood loss was 350 (range, 300-600) mL, and the grades B and C pancreatic fistula was 23...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27645384/opening-the-channel-the-two-functional-interfaces-of-pseudomonas-aeruginosa-opmh-with-the-triclosan-efflux-pump-triabc
#13
Abigail T Ntreh, Jon W Weeks, Logan M Nickels, Helen I Zgurskaya
: TriABC-OpmH is an efflux pump from Pseudomonas aeruginosa with an unusual substrate specificity and protein composition. When overexpressed, this pump confers a high level of resistance to the biocide triclosan and the detergent SDS, which are commonly used in combinations for antimicrobial treatments. This activity requires an RND transporter (TriC), an outer membrane channel (OpmH), and two periplasmic membrane fusion proteins (TriA and TriB) with nonequivalent functions. In the active complex, TriA is responsible for the recruitment of OpmH, while TriB is responsible for stimulation of the transporter TriC...
December 1, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27579747/rheumatoid-arthritis-and-pseudo-vesicular-skin-plaques-rheumatoid-neutrophilic-dermatosis
#14
Juan Manriquez, Laura Giesen, Constanza Del Puerto, Sergio Gonzalez
A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After 3 days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27576779/renal-nerve-denervation-adherence-and-management-of-resistant-hypertension
#15
EDITORIAL
David A Calhoun
No abstract text is available yet for this article.
September 20, 2016: Circulation
https://www.readbyqxmd.com/read/27553408/mmpl-transporter-mediated-export-of-cell-wall-associated-lipids-and-siderophores-in-mycobacteria
#16
REVIEW
Christian Chalut
Mycobacteria produce a large variety of surface-exposed lipids with unusual structures. Some of these compounds are ubiquitously present in mycobacteria and play an important role in the structural organization of the cell envelope, while others are species-specific. The biosynthesis of most of these lipids requires modular polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) that are intracellular, suggesting that the assembly of these compounds takes place in the cytosolic compartment or near the inner leaflet of the plasma membrane...
September 2016: Tuberculosis
https://www.readbyqxmd.com/read/27508846/-op-7d-04-changes-in-renal-hemodynamic-and-tubular-sodium-handling-one-year-after-transcatheter-renal-denervation-in-resistant-hypertension
#17
F Megdiche, N Vakilzadeh, M Maillard, E Grouzmann, M Burnier, G Wuerzner
OBJECTIVE: The sympathetic nervous system is implicated in most form of hypertension. In resistant hypertension, transcatheter renal denervation (RDN) has been proposed as an adjunctive therapy to antihypertensive drugs at maximum tolerated doses. The results on blood pressure (BP) reduction have been the source of debate. Few studies have explored the effect on renal hemodynamics and tubular sodium handling. The objective was to assess these two parameters before RND and after 1 and 12 months...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27450181/screening-of-natural-products-and-derivatives-for-identification-of-rnd-efflux-pump-inhibitors
#18
Debarati Choudhury, Anupam Das Talukdar, Pankaj Chetia, Amitabha Bhattacharjee, Manabendra Dutta Choudhury
AIM AND OBJECTIVE: Overexpression of efflux pumps belonging to the Resistance Nodulation cell Division (RND) family is the most important intrinsic resistance mechanism of Pseudomonas aeruginosa. Hence, it is imperative to identify suitable efflux pump inhibitors (EPI) that can lead to increased intracellular concentration of antibiotics by blocking the pump. This study was undertaken to identify a putative plant based efflux pump inhibitor for RND efflux pump of P. aeruginosa. MATERIAL AND METHOD: Using molecular docking approach, 328 secondary plant metabolites have been screened for their inhibitory activity against cytoplasmic exporter protein MexB of MexAB-OprM efflux pump of P...
July 20, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27392063/identification-functional-characterization-and-regulon-prediction-of-a-novel-two-component-system-comprising-bas0540-bas0541-of-bacillus-anthracis
#19
Monisha Gopalani, Alisha Dhiman, Amit Rahi, Divya Kandari, Rakesh Bhatnagar
Two component systems (TCSs) can be envisaged as complex molecular devices that help the bacteria to sense its environment and respond aptly. 41 TCSs are predicted in Bacillus anthracis, a potential bioterrorism agent, of which only four have been studied so far. Thus, the intricate signaling network contributed by TCSs remains largely unmapped in B. anthracis and needs comprehensive exploration. In this study, we functionally characterized one such system composed of BAS0540 (Response regulator) and BAS0541 (Histidine kinase)...
2016: PloS One
https://www.readbyqxmd.com/read/27347214/snail-levels-control-the-migration-mechanism-of-mesenchymal-tumor-cells
#20
Cristina Belgiovine, Giulio Chiesa, Ilaria Chiodi, Roberta Frapolli, Katiuscia Bonezzi, Giulia Taraboletti, Maurizio D'Incalci, Chiara Mondello
Cancer cells use two major types of movement: Mesenchymal, which is typical of cells of mesenchymal origin and depends on matrix metalloproteinase (MMP) activity, and amoeboid, which is characteristic of cells with a rounded shape and relies on the activity of Rho-associated kinase (ROCK). The present authors previously demonstrated that, during neoplastic transformation, telomerase-immortalized human fibroblasts (cen3tel cells) acquired a ROCK-dependent/MMP independent mechanism of invasion, mediated by the downregulation of the ROCK cellular inhibitor Round (Rnd)3/RhoE...
July 2016: Oncology Letters
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