Yulan Liu, Sihan Lin, Zeqian Xu, Yuqiong Wu, Guifang Wang, Guangzheng Yang, Lingyan Cao, Haishuang Chang, Mingliang Zhou, Xinquan Jiang
The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired by the discovery that the endoplasmic reticulum (ER) is in a state of excessive stress and dysfunction under hyperglycemia, leading to osteogenic disorder, a novel engineered exosome is proposed to modulate ER homeostasis for restoring the function of mesenchymal stem cells (MSCs). The results indicate that the constructed engineered exosomes efficiently regulate ER homeostasis and dramatically facilitate the function of MSCs in the hyperglycemic niche...
February 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)