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https://www.readbyqxmd.com/read/28651262/relationship-of-radiographic-osteoarthritis-severity-with%C3%A2-treatment-outcomes-after-imaging-guided-knee%C3%A2-injections-a-prospective-outcomes-study
#1
Ivan Miletic, Christoph Agten, Reto Sutter, Christian Pfirrmann, Cynthia Peterson
Introduction To be able to predict which patients are more likely to have a positive treatment outcome, the purpose of this study is 1: To compare outcomes after intra-articular corticosteroid knee injections with the Kellgren and Lawrence (KL) 5 and 3 grading systems for knee osteoarthritis, the Osteoarthritis Research Society International (OARSI) grading system and actual joint space measurements; and 2: To compare the reliability of these grading systems. Materials and Methods Knee radiographs of 117 patients who received intra-articular corticosteroid injections were independently evaluated by two radiologists blinded to the outcome...
June 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28650969/development-and-psychometric-properties-of-knee-specific-body-perception-questionnaire-in-people-with-knee-osteoarthritis-the-fremantle-knee-awareness-questionnaire
#2
Tomohiko Nishigami, Akira Mibu, Katsuyoshi Tanaka, Yuh Yamashita, Eiji Yamada, Benedict M Wand, Mark J Catley, Tasha R Stanton, G Lorimer Moseley
BACKGROUND: Recent systematic reviews have demonstrated that pain associated with knee osteoarthritis (OA) is a complex phenomenon that involves various contributors. People with knee OA exhibit symptoms of impaired body-perception, including reduced tactile acuity, impairments in limb laterality recognition, and degraded proprioceptive acuity. The Fremantle Back Awareness Questionnaire (FreBAQ) was developed to assess body-perception specific to the back in people with chronic low back pain...
2017: PloS One
https://www.readbyqxmd.com/read/28650946/the-hyperextension-tibial-plateau-fracture-pattern-a-predictor-of-poor-outcome
#3
Leah J Gonzalez, Ariana Lott, Sanjit Konda, Kenneth A Egol
OBJECTIVES: To assess the outcome of patients with hyperextension bicondylar tibial plateau fractures (HEBTP) to those with other complex tibial plateau fractures DESIGN:: Retrospective cohort design SETTING:: Academic Medical Center PATIENTS:: A total of 84 patients were included in the study. There were 69 patients with 69 knees (82%) that had sustained non-hyperextension bicondylar tibial plateau fractures and 15 patients with 15 knees (18%) that had hyperextension bicondylar tibial plateau fractures (HEBTP) INTERVENTION:: Surgical repair of bicondylar tibial plateau fracture MAIN OUTCOME MEASURES:: Clinical and functional outcomes included knee range of motion, post-operative alignment, NRS pain scores and Short Musculoskeletal Functional Assessment (SMFA) scores at long-term follow-up...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28649018/rear-foot-kinematics-when-wearing-lateral-wedge-insoles-and-foot-alignment-influence-the-effect-of-knee-adduction-moment-for-medial-knee-osteoarthritis
#4
Tomonori Sawada, Kenji Tanimoto, Kazuki Tokuda, Yoshitaka Iwamoto, Yuta Ogata, Masaya Anan, Makoto Takahashi, Nobuhiro Kito, Koichi Shinkoda
Lateral wedge insoles (LWIs) are prescribed for patients with medial knee osteoarthritis to reduce the external knee adduction moment (KAM). However, the biomechanical effects of LWIs are limited in some patients. The purpose of this study was to investigate whether the biomechanical effects of LWIs depend on individual foot alignment and to examine the relationship between change in KAM and changes in foot and ankle biomechanics when wearing LWIs. Twenty-one patients participated in this study. They were categorized into normal or abnormal foot groups based on the foot posture index (FPI)...
June 15, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28648740/patellofemoral-morphology-and-alignment-reference-values-and-dose-response-patterns-for-the-relation-to-mri-features-of-patellofemoral-osteoarthritis
#5
Erin M Macri, David T Felson, Yuqing Zhang, Ali Guermazi, Frank W Roemer, Kay M Crossley, Karim M Khan, Josh J Stefanik
OBJECTIVE: We aimed to (i) determine reference values for trochlear morphology and patellofemoral (PF) alignment in adults without MRI-defined PF full thickness cartilage damage or knee pain; and (ii) evaluate dose-response patterns for these measures with prevalent MRI-defined PF structural damage and/or knee pain. DESIGN: The Framingham Community Cohort is a population-based sample of ambulatory adults aged ≥50 years. We evaluated six morphology and alignment measures using MRI (n=985), and reported reference values (mean ± 2SD) in a subsample without MRI-defined PF full thickness cartilage damage or knee pain (n=563)...
June 22, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28648704/total-knee-arthroplasty-using-bicruciate-stabilized-or-posterior-stabilized-knee-implants-provided-comparable-outcomes-at-2-years-a-prospective-multicenter-randomized-controlled-clinical-trial-of-patient-outcomes
#6
Jennie M Scarvell, Diana M Perriman, Paul N Smith, David G Campbell, Warwick J M Bruce, Bo Nivbrant
BACKGROUND: The bicruciate-stabilized (BCS) knee arthroplasty was developed to replicate normal knee kinematics. We examined the hypothesis that patients with osteoarthritis requiring total knee arthroplasty (TKA) will have better functional outcome and satisfaction with the BCS implant compared with an established posterior cruciate-stabilized implant. METHODS: This multicenter, randomized, controlled trial compared the clinical outcomes of a BCS implant against an established posterior cruciate-stabilized implant with 2-year follow-up...
May 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28648299/the-intra-articular-injection-of-rankl-binding-peptides-inhibits-cartilage-degeneration-in-a-murine-model-of-osteoarthritis
#7
Md Zahirul Haque Bhuyan, Yukihiko Tamura, Eri Sone, Yuki Yoshinari, Chizuko Maeda, Mariko Takahashi, Yasuhiko Tabata, Ramachandran Murali, Yoshihiro Waki, Kazuhiro Aoki
We recently found that the receptor activator of NF-κB ligand (RANKL)-binding peptide, OP3-4 stimulated the differentiation of both chondrocytes and osteoblasts. OP3-4 is also shown to inhibit cartilage degeneration. To clarify whether the peptide can inhibit cartilage degeneration without stimulating bone formation, we first performed a proliferation assay using C3H10T1/2 (the murine mesenchymal stem cell line), which is the common origin of both chondrocytes and osteoblasts. The RANKL-binding peptides, OP3-4 and W9, promoted cellular proliferation at 24 and 48 h, respectively...
June 13, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28648126/knee-osteoarthritis-and-risk-of-hypertension-a-longitudinal-cohort-study
#8
Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby Smith, Marianna Noale, Patricia Schofield, Stefania Maggi
Whilst previous research has indicated an association between osteoarthritis and cardiovascular disease, it remains unclear whether people with osteoarthritis are at greater risk of developing hypertension. The aim of this study was to answer this uncertainity. We used the data of the Osteoarhritis Iniative, an ongoing public and private longitudinal study including people at higher risk of osteoarthritis or having knee osteoarthritis. Knee osteoarthritis was defined through radiological and clinical assessment...
June 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28647729/analgesic-effects-of-diluted-bee-venom-acupuncture-mediated-by-%C3%AE-opioid-and-%C3%AE-2-adrenergic-receptors-in-osteoarthritic-rats
#9
Jeong-Eun Huh, Byung-Kwan Seo, Jung-Woo Lee, Yeon-Cheol Park, Yong-Hyeon Baek
Context • Pain from osteoarthritis is associated with peripheral nociception and central pain processing. Given the unmet need for innovative, effective, and well-tolerated therapies, many patients, after looking for more satisfactory alternatives, decide to use complementary and alternative modalities. The analgesic mechanism of subcutaneous injections of diluted bee venom into an acupoint is thought to be part of an anti-inflammatory effect and the central modulation of pain processing. Objectives • Using the rat model of collagenase-induced osteoarthritis (CIOA), the study intended to investigate the analgesic effects of bee venom acupuncture (BVA) as they are related to the acupuncture points and dosage used and to determine whether the analgesic mechanisms of BVA for pain were mediated by opioid or adrenergic receptors...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28647718/new-meniscal-tears-after-acl-injury-what-is-the-risk-a-systematic-review-protocol
#10
REVIEW
Guri Ranum Ekås, Clare Ardern, Hege Grindem, Lars Engebretsen
BACKGROUND: Secondary meniscal tears after ACL injuries increase the risk of knee osteoarthritis. The current literature on secondary meniscal injuries after ACL injury is not consistent and may have methodological shortcomings. This protocol describes the methods of a systematic review investigating the rate of secondary meniscal injuries in children and adults after treatment (operative or non-operative) for ACL injury. METHODS: We will search electronic databases (Embase, Ovid Medline, Cochrane, CINAHL (Cumulative Index to Nursing and Allied Health Literature), SPORTDiscus, PEDro and Google Scholar) from database inception...
June 24, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28647559/mirna-146a-mirna-155-and-jnk-expression-levels-in-peripheral-blood-mononuclear-cells-according-to-grade-of-knee-osteoarthritis
#11
Ahu Soyocak, Hulyam Kurt, Merih Ozgen, Didem Turgut Cosan, Ertugrul Colak, Hasan Veysi Gunes
Osteoarthritis (OA) is the most common joint disease characterized by joint pain and a progressive loss of articular cartilage. OA known as a non-inflammatory disease. Despite this the recent studies are shown synovitis and low inflammation to have a role in OA pathophysiology. The aim of this study to determine the roles of a potential therapeutic targets miRNA-146a, miRNA-155 and JNK expression levels in OA patients. Peripheral mononuclear blood cells (PBMCs) were extracted from OA patients and healthy subjects...
June 21, 2017: Gene
https://www.readbyqxmd.com/read/28647467/reliability-and-measurement-error-of-the-osteoarthritis-research-society-international-recommended-performance-based-tests-of-physical-function-in-people-with-hip-and-knee-osteoarthritis
#12
Fiona Dobson, Rana S Hinman, Michelle Hall, Charlotte J Marshall, Tim Sayer, Clinton Anderson, Nicolas Newcomb, Paul W Stratford, Kim L Bennell
OBJECTIVE: To estimate the reliability and measurement error of performance-based tests of physical function recommended by the Osteoarthritis Research Society International in people with hip and/or knee osteoarthritis. DESIGN: Prospective repeated measures between independent raters within a session and within-rater over a week interval. Relative reliability was estimated for 51 people with hip and/or knee osteoarthritis (mean age 64.5 years, SD 6.21 years; 47% females; 36 (70%) primary knee OA) on the 30s Chair Stand Test (30sCST), 40m Fast Paced Walk Test (40mFPWT), 11-Stair Climb Test (11-step SCT), Timed Up and Go (TUG), Six Minute Walk Test (6MWT), 10m Fast Paced Walk Test (10mFPWT) and 20s Stair Climb Test (20sSCT) using intra-class correlation coefficients (ICC)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28646530/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#13
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28645453/choice-of-knee-cartilage-thickness-change-metric-for-different-treatment-goals-in-efficacy-studies
#14
Robert J Buck, Marie-Pierre Hellio Le Graverand, Wolfgang Wirth, Felix Eckstein
INTRODUCTION: In knee osteoarthritis, local increase and decrease in cartilage thickness has been observed over short time intervals. Hence, averaging cartilage change across large regions may not capture the complexity of structural alterations in disease progression. This study aims to examine the relative performance of different metrics of cartilage thickness change for different clinical studies scenarios. MATERIALS AND METHODS: Metrics for assessing cartilage thickness change were characterized by conventional measures of change versus absolute values (the magnitude) of change, and by different methods of summarizing change over (sub-) regions...
May 30, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28645132/platelet-rich-plasma-for-the-treatment-of-knee-osteoarthritis-a-review
#15
Nicolas S Piuzzi, Morad Chughtai, Anton Khlopas, Steven F Harwin, Anthony Miniaci, Michael A Mont, George F Muschler
No abstract text is available yet for this article.
June 23, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28644677/young-athletes-after-anterior-cruciate-ligament-reconstruction-with-single-leg-landing-asymmetries-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-2-years-later
#16
Matthew P Ithurburn, Mark V Paterno, Kevin R Ford, Timothy E Hewett, Laura C Schmitt
BACKGROUND: Previous work shows that young athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate single-leg (SL) landing movement asymmetries at the time of return to sport (RTS); however, the effect of movement asymmetries on longitudinal knee-related function after ACLR has not been examined. Hypothesis/Purpose: The purpose of this study was to examine the effect of SL drop-landing movement symmetry at the time of RTS on knee-related function 2 years later in young athletes after ACLR...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28642979/-medial-opening-wedge-high-tibial-osteotomy
#17
REVIEW
P Niemeyer, A Stöhr, M Köhne, A Hochrein
OBJECTIVE: Reduction of the load to the medial compartment in patients with medial knee osteoarthritis and varus malalignment. Unloading of the posterolateral complex in varus deformity with complex ligamentous laxity. INDICATIONS: Medial knee osteoarthritis and varus malalignment with largely intact lateral and patellofemoral joint aspect. Complex ligament insufficiency combined with varus deformity. CONTRAINDICATIONS: Substantially impaired range of motion...
June 22, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28642646/intensity-duration-and-type-of-physical-activity-required-to-improve-function-in-knee-osteoarthritis
#18
Ricardo Akihiro Kirihara, Fellipe Bravim Catelan, Fabiane Elize Sabino DE Farias, Cleidnéia Aparecida Clemente DA Silva, Claudia Helena DE Azevedo Cernigoy, Márcia Uchoa DE Rezende
OBJECTIVE: To evaluate the effects of physical activity intensity, type and duration in patients with knee osteoarthritis (KOA) . METHODS: A retrospective study of 195 KOA patients who were followed for two years after receiving educational material about KOA with or without attending classes. The patients were evaluated at baseline and 24 months. At the evaluations, the patients answered questionnaires pertaining to pain and function (WOMAC, Lequesne, VAS and SF-36); reported the intensity, duration and type of exercise performed per week; and performed the Timed Up & Go (TUG) and Five Times Sit-to-Stand (FTSST) tests ...
January 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642645/parqve-project-arthritis-recovering-quality-of-life-through-education-two-year-results
#19
Márcia Uchoa DE Rezende, Renato Frucchi, Alexandre Felício Pailo, Gustavo Constantino DE Campos, Thiago Pasqualin, Marcelo Issao Hissadomi
OBJECTIVE: To evaluate the effects of a multi-professional educational program in patients with knee osteoarthritis (KOA) . METHODS: Prospective randomized controlled trial with 195 KOA patients. One group was submitted to two-day lectures and received educational material about KOA (Class group), and the control group received the educational material only. Patients were evaluated at baseline, twelve and 24 months. At evaluation, patients answered pain and functional questionnaires (WOMAC, Lequesne, VAS and SF-36); reported the intensity of exercise per week; measured the body fat percentage, weight and height to estimate body mass index (BMI); and performed Timed Up & Go (TUG) and Five-Times-Sit-to-Stand (FTSST) tests ...
January 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642490/relationship-between-kellgren-lawrence-score-and-3d-kinematic-gait-analysis-of-patients-with-medial-knee-osteoarthritis-using-a-new-gait-system
#20
Xiaolong Zeng, Limin Ma, Zefeng Lin, Wenhan Huang, Zhiqiang Huang, Yu Zhang, Chuanbin Mao
Knee osteoarthritis (KOA) is reported to have characteristic kinematics during walking. However, the relationship between Kellgren-Lawrence (K/L) score and the 3D kinematic gait of patients with medial KOA remains unclear. Here, ninety-seven patients with medial KOA and thirty-eight asymptomatic participants were involved. Patients with medial KOA were divided into early, moderate, and severe KOA based on the K/L score. Through kinematic gait analysis, we found a relationship between K/L score and 3D kinematic gait for patients...
June 22, 2017: Scientific Reports
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