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https://www.readbyqxmd.com/read/29223778/differences-in-trochlear-parameters-between-native-and-prosthetic-kinematically-or-mechanically-aligned-knees
#1
C Rivière, F Iranpour, S Harris, E Auvinet, A Aframian, S Parratte, J Cobb
INTRODUCTION: Kinematic (KA) and mechanical (MA) alignment techniques are two different philosophies of implant positioning that use the same TKA implants. This might generate differences in the resulting prosthetic trochlea parameters between the two techniques of alignment. Our study aim was to test the following hypotheses: 1) Mechanically or kinematically aligned femoral implant understuffs the native trochlear articular surface and poorly restores the native groove orientation, and 2) The orientation of the prosthetic trochlear groove and trochlear fill are different between MA and KA...
December 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#2
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29222056/are-bisphosphonates-efficacious-in-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#3
Elizaveta E Vaysbrot, Mikala C Osani, Mia-Cara Musetti, Timothy E McAlindon, Raveendhara R Bannuru
OBJECTIVE: To clarify the effects of bisphosphonates in knee osteoarthritis (OA) using an up-to-date meta-analysis of randomized controlled trials (RCTs). DESIGN: The protocol is registered in PROSPERO (CRD42017073449). We searched MEDLINE, EMBASE, Google Scholar, Web of Science, and Cochrane Database from inception until August 2017. We included only RCTs comparing any bisphosphonates vs. placebo in knee OA patients and reporting validated pain and function scales, radiographic progression, and adverse events outcomes...
December 5, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29221902/a-comparison-of-patellofemoral-cartilage-morphology-and-deformation-in-anterior-cruciate-ligament-deficient-versus-uninjured-knees
#4
Kwadwo A Owusu-Akyaw, Lauren N Heckelman, Hattie C Cutcliffe, E Grant Sutter, Zoë A Englander, Charles E Spritzer, William E Garrett, Louis E DeFrate
Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics may predispose patients to cartilage degeneration. This study aimed to compare in vivo PFJ morphology and mechanics between ACL deficient and intact knees in subjects with unilateral ACL ruptures. Eight male subjects underwent baseline MRI scans of both knees...
November 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221756/characterization-of-the-binding-site-for-d-deprenyl-in-human-inflamed-synovial-membrane
#5
Anna Lesniak, Mikko Aarnio, Shanti Diwakarla, Thomas Norberg, Fred Nyberg, Torsten Gordh
AIMS: d-Deprenyl when used as a positron emission tomography tracer visualizes peripheral inflammation. The major aim of the current study was to identify and investigate the properties of the binding target for d-deprenyl in synovial membrane explants from arthritic patients. MAIN METHODS: Thirty patients diagnosed with arthritis or osteoarthritis were enrolled into the study. Homologous and competitive radioligand binding assays utilizing [3H]d-deprenyl were performed to investigate the biochemical characteristics of the binding site and assess differences in the binding profile in synovial membranes exhibiting varying levels of inflammation...
December 5, 2017: Life Sciences
https://www.readbyqxmd.com/read/29221481/association-of-body-mass-index-with-knee-cartilage-damage-in-an-asymptomatic-population-based-study
#6
Alvin Keng, Eric C Sayre, Ali Guermazi, Savvakis Nicolaou, John M Esdaile, Anona Thorne, Joel Singer, Jacek A Kopec, Jolanda Cibere
BACKGROUND: Cartilage changes are an important early finding of osteoarthritis (OA), which can exist even before symptoms. Our objective was to determine the prevalence of knee cartilage damage on magnetic resonance imaging (MRI) in an asymptomatic population-based cross-sectional study and to evaluate the association of body mass index (BMI) with cartilage damage. METHODS: Subjects, aged 40-79 years, without knee pain (n = 73) were recruited as a random population sample and assessed for BMI (kg/m2), including current BMI (measured), past BMI at age 25 (self-reported) and change in BMI...
December 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29221471/in-home-versus-hospital-preoperative-balance-and-proprioceptive-training-in-patients-undergoing-tkr-rationale-design-and-method-of-a-randomized-controlled-trial
#7
José-María Blasco, Celedonia Igual-Camacho, Sergio Roig-Casasús
BACKGROUND: Severe knee osteoarthritis, as well as the surgical procedure of total knee replacement that aims to reduce its symptoms, cause great deterioration on the proprioceptive system. Taking this fact into account, and considering that balance abilities positively influence the capacity to perform basic functional tasks, this trial aims to find the short and mid-term effects of a preoperative balance and proprioceptive training when conducted by patients undergoing total knee replacement...
December 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29221427/validity-of-the-dutch-modified-paindetect-questionnaire-for-patients-with-hip-or-knee-osteoarthritis
#8
Wietske Rienstra, Tim Blikman, Baukje Dijkstra, Jos van Raay, Geranda Slager, Sjoerd Bulstra, Martin Stevens, Inge van den Akker-Scheek
BACKGROUND: The modified painDETECT questionnaire (PDQ) is a self-reported questionnaire to discriminate between nociceptive and neuropathic-like pain in patients with knee/hip osteoarthritis (OA). This study aims to assess the structural and construct validity of this questionnaire. METHODS: Confirmatory factor analysis and hypothesis-testing was used. For 168 patients, predefined hypotheses were formulated on the correlation between the modified painDETECT and several other questionnaires, and in a subsample of 46 with pain pressure thresholds (PPTs)...
December 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29219023/tenascin-c-prevents-articular-cartilage-degeneration-in-murine-osteoarthritis-models
#9
Yuriyo Matsui, Masahiro Hasegawa, Takahiro Iino, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Akihiro Sudo
Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and its distribution was examined at 1 day, 4 days, 1 week, 2 weeks, and 4 weeks postinjection. To investigate the effects of TNC on cartilage degeneration after surgery to knee joints, articular spaces were filled with 100 μg/mL (group I), 10 μg/mL (group II) of TNC solution, or control (group III)...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219022/effectiveness-of-radiofrequency-hyperthermia-for-treating-cartilage-in-guinea-pigs-with-primary-osteoarthritis
#10
Kenji Takahashi, Hiroshi Nakamura, Hitoshi Ozawa, Sanshiro Hashimoto, Norio Iijima, Shimpei Higo, Hiroshi Watanabe, Yusuke Mochizuki, Shinro Takai
Objective Autophagy was reported to be essential for maintaining chondrocyte function, and reduced autophagy leads to osteoarthritis (OA). Previous studies showed involvement of heat shock stress in the control of autophagy in cells. This study sought to investigate the effect of hyperthermia on the expression of autophagy-related proteins in articular cartilage and the progression of naturally occurring OA in Hartley guinea pigs. Design Radiofrequency pulses of 13.56 MHz were applied to the animals' knees for 20 minutes to induce hyperthermia...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#11
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219018/gender-differences-in-knee-joint-congruity-quantified-from-mri-a-validation-study-with-data-from-center-for-clinical-and-basic-research-and-osteoarthritis-initiative
#12
Sudhakar Tummala, Dieuwke Schiphof, Inger Byrjalsen, Erik B Dam
Objective Gender is a risk factor in the onset of osteoarthritis (OA). The aim of the study was to investigate gender differences in contact area (CA) and congruity index (CI) in the medial tibiofemoral (MTF) joint in 2 different cohorts, quantified automatically from magnetic resonance imaging (MRI). Design The CA and CI markers were validated on 2 different data sets from Center for Clinical and Basic Research (CCBR) and Osteoarthritis Initiative (OAI). The CCBR cohort consisted of 159 subjects and the OAI subcohort consisted of 1,436 subjects...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29216898/is-the-relationship-between-increased-knee-muscle-strength-and-improved-physical-function-following-exercise-dependent-on-baseline-physical-function-status
#13
Michelle Hall, Rana S Hinman, Martin van der Esch, Marike van der Leeden, Jessica Kasza, Tim V Wrigley, Ben R Metcalf, Fiona Dobson, Kim L Bennell
BACKGROUND: Clinical guidelines recommend knee muscle strengthening exercises to improve physical function. However, the amount of knee muscle strength increase needed for clinically relevant improvements in physical function is unclear. Understanding how much increase in knee muscle strength is associated with improved physical function could assist clinicians in providing appropriate strength gain targets for their patients in order to optimise outcomes from exercise. The aim of this study was to investigate whether an increase in knee muscle strength is associated with improved self-reported physical function following exercise; and whether the relationship differs according to physical function status at baseline...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29214949/-a-review-on-psychosomatic-factors-affecting-the-outcome-after-total-knee-arthroplasty-tka
#14
Matthias Vogel, Christian Riediger, Sebastian Illiger, Jörg Frommer, Christoph H Lohmann
A review on psychosomatic factors affecting the outcome after total knee-arthroplasty (TKA) Objectives: In today's ageing Western societies, arthroplasty is a common treatment for endstage osteoarthritis. Despite highly developed implants and surgery, however, this treatment does not always succeed in relieving pain and restoring joint function, i.e., in restoring satisfactory algofunction. Clinicians partly blame psychological factors for this discrepancy, especially in the absence of objective medical complications...
December 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/29214918/effects-of-knee-orthosis-adjustment-on-biomechanical-performance-and-clinical-outcome-in-patients-with-medial-knee-osteoarthritis
#15
Andreas Brand, Isabella Klöpfer-Krämer, Mario Morgenstern, Inga Kröger, Björn Michel, Andreas Thannheimer, Janina Anna Müßig, Peter Augat
BACKGROUND: Valgus bracing in medial knee osteoarthritis aims to improve gait function by reducing the loading of the medial compartment. Orthosis composition and optimal adjustment is essential to achieve biomechanical and clinical effectiveness. OBJECTIVES: To investigate biomechanical functionality during gait, pain relief and compliance in patients with knee osteoarthritis using a lightweight adjustable knee unloader orthosis. STUDY DESIGN: Prospective observational clinical trial...
December 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29214616/a-randomized-controlled-trial-evaluating-methylsulfonylmethane-versus-placebo-to-prevent-knee-pain-in-military-initial-entry-trainees
#16
David J Tennent, Christina M Hylden, Benjamin K Kocher, James K Aden, Anthony E Johnson
BACKGROUND: Methylsulfonylmethane (MSM) is a naturally occurring sulfur containing substance that has been shown to have anti-inflammatory and antioxidative properties. Previous studies using MSM as an oral supplement to improve pain in those patients with knee osteoarthritis have shown superiority compared to placebo. However, these studies are not translatable to active individuals performing high impact activities and have not evaluated MSM as a preventative measure. METHODS: A total of 180 subjects ranging in age from 18 to 40 years were enrolled...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29213100/altered-spontaneous-calcium-signaling-of-in-situ-chondrocytes-in-human-osteoarthritic-cartilage
#17
Xiaoyuan Gong, Wenbin Xie, Bin Wang, Lingchuan Gu, Fuyou Wang, Xiang Ren, Cheng Chen, Liu Yang
Intracellular calcium ([Ca2+]i) signaling is an essential universal secondary messenger in articular chondrocytes. However, little is known about its spatiotemporal features in the context of osteoarthritis (OA). Herein, by examining the cartilage samples collected from patients undergoing knee arthroscopic surgery, we investigated the spatiotemporal features of spontaneous [Ca2+]i signaling in in situ chondrocytes at different OA stages. Our data showed zonal dependent spontaneous [Ca2+]i signaling in healthy cartilage samples under 4 mM calcium environment...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212997/-the-effects-of-pain-coping-skills-training-among-older-outpatients-with-osteoarthritis
#18
Yasuhiro Nagasawa, Koichiro Oka, Ai Shibata
AIM: The present study examined the effects of individual pain coping-skills training (PCST) on knee pain, pain coping strategies, physical functions, and daily physical activity among older outpatients with osteoarthritis. METHODS: Twenty-five older adults who suffered from knee pain and had been diagnosed to have knee osteoarthritis (men: n=4; 75.4±6.3 years) were assigned to either a PCST group (n=13) or a general health education group (n=12) according to their wishes...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29212511/comparing-the-chinese-versions-of-two-knee-specific-questionnaires-ikdc-and-koos-reliability-validity-and-responsiveness
#19
Chien-Chih Huang, Wen-Shiang Chen, Mei-Wun Tsai, Wendy Tzyy-Jiuan Wang
BACKGROUND: The International Knee Documentation Committee Subjective Knee Form (IKDC) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) are knee-specific questionnaires that have been widely used and translated into numerous languages. However, the differences in the psychometric properties between the Chinese IKDC and KOOS remain unclear. The purpose of this study was to conduct a cross-cultural adaptation of the Chinese IKDC and Chinese KOOS and to compare the psychometric properties of these two measures in patients with various knee injuries from the acute stage up to 12 weeks after receiving treatment...
December 6, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29212436/estimation-of-individual-thigh-muscle-volumes-from-a-single-slice-muscle-cross-sectional-area-and-muscle-thickness-using-magnetic-resonance-imaging-in-patients-with-knee-osteoarthritis
#20
Koun Yamauchi, Akito Yoshiko, Shigetoshi Suzuki, Chisato Kato, Hiroshi Akima, Takayuki Kato, Koji Ishida
PURPOSE: This study aimed to identify the best single-slice anatomical muscle cross-sectional area (CSA) and muscle thickness (MT) on magnetic resonance imaging (MRI) to estimate the overall individual muscle volumes (MVs) of knee extensors and flexors in patients with knee osteoarthritis (KOA). METHODS: Twelve patients (24 legs; 4 men and 8 women) with KOA underwent a 1.5-Tesla axial MRI scan in the femoral region of interest (ROI), between the lesser trochanter and rectus femoris tendon...
September 2017: Journal of Orthopaedic Surgery
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