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t1 colorectal carcinoma

Subhash Chander Singla, Dhawal Kaushal, Harinder Singh Sagoo, Nalini Calton
BACKGROUND: The staging of colorectal carcinoma using 3 modalities viz operative, histopathology and CT scan has been subject of interest in accurately defining the extent of disease. This retrospective as well as prospective study was carried out at CMC, Ludhiana, Punjab from November 2011 to May 2014. AIM: The objective of this study was to assess the usefulness and accuracy of CT scan findings to state the extent and spread of colorectal malignancy and to correlate these findings with histopathological diagnosis...
January 2017: International Journal of Applied and Basic Medical Research
Yuzuru Tamaru, Shiro Oka, Shinji Tanaka, Shinji Nagata, Yuko Hiraga, Toshio Kuwai, Akira Furudoi, Tadamasa Tamura, Masaki Kunihiro, Hideharu Okanobu, Koichi Nakadoi, Hiroyuki Kanao, Makoto Higashiyama, Koji Arihiro, Kazuya Kuraoka, Fumio Shimamoto, Kazuaki Chayama
BACKGROUND: We aimed to clarify the long-term outcomes of patients with T1 colorectal carcinoma (CRC) after endoscopic resection (ER) and surgical resection. METHODS: We examined T1 CRC patients treated during 1992-2008 and who had ≥5 years of follow-up. Patients who did not meet the curative criteria after ER according to the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines were defined as "non-endoscopically curable" and classified into three groups: ER alone (Group A: 121 patients), additional surgery after ER (Group B: 238 patients), and surgical resection alone (Group C: 342 patients)...
February 13, 2017: Journal of Gastroenterology
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
Masaki Yamamoto, Kiyoshi Hasegawa, Junichi Arita, Ryohei Maeno, Nobuhisa Akamatsu, Junichi Kaneko, Takeyuki Watadani, Naoki Okura, Akimasa Hayashi, Junji Shibahara, Yoshihiro Sakamoto, Kuni Ohtomo, Masashi Fukayama, Norihiro Kokudo
INTRODUCTION: A hepatic schwannoma is extremely rare and difficult to diagnose preoperatively. PRESENTATION OF CASE: We report the case of a 47-year-old male patient who was referred to our hospital for the close investigation of a hepatic tumor which had not been detected two years earlier. An enhanced computed tomography revealed a well-circumscribed and encapsulated tumor with a size of 50mm which was adjacent to the inferior vena cava (IVC) and the right hepatic vein...
2016: International Journal of Surgery Case Reports
Yui Jennifer Kimura, Shin-Ei Kudo, Hideyuki Miyachi, Katsuro Ichimasa, Yuta Kouyama, Masashi Misawa, Yuta Sato, Shingo Matsudaira, Hiromasa Oikawa, Tomokazu Hisayuki, Yuichi Mori, Toyoki Kudo, Noriyuki Ogata, Kenta Kodama, Kunihiko Wakamura, Takemasa Hayashi, Atsushi Katagiri, Toshiyuki Baba, Eiji Hidaka, Fumio Ishida, Shigeharu Hamatani
BACKGROUND/AIM: Previous reports stated that pedunculated T1 colorectal carcinomas with 'head invasion' showed almost no nodal metastasis, requiring endoscopic treatment alone. However, clinically, some lesions develop nodal metastasis. We aimed to validate the necessity of distinguishing between 'pedunculated' and 'non-pedunculated' lesions, and also between 'head' and 'stalk' invasions. METHODS: Initial or additional surgery with lymph node dissection was performed in 76 pedunculated and 594 non-pedunculated cases...
2016: Digestion
A Overwater, K Kessels, S G Elias, Y Backes, B W M Spanier, T C J Seerden, H J M Pullens, W H de Vos Tot Nederveen Cappel, A van den Blink, G J A Offerhaus, J van Bergeijk, M Kerkhof, J M J Geesing, J N Groen, N van Lelyveld, F Ter Borg, F Wolfhagen, P D Siersema, M M Lacle, L M G Moons
OBJECTIVE: It is difficult to predict the presence of histological risk factors for lymph node metastasis (LNM) before endoscopic treatment of T1 colorectal cancer (CRC). Therefore, endoscopic therapy is propagated to obtain adequate histological staging. We examined whether secondary surgery following endoscopic resection of high-risk T1 CRC does not have a negative effect on patients' outcomes compared with primary surgery. DESIGN: Patients with T1 CRC with one or more histological risk factors for LNM (high risk) and treated with primary or secondary surgery between 2000 and 2014 in 13 hospitals were identified in the Netherlands Cancer Registry...
November 3, 2016: Gut
Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Masahiro Yoshimura, Tomoharu Shimizu, Masaji Tani, Ryoji Kushima, Kiyoshi Murata
PURPOSE: To evaluate the feasibility of assessing advanced T-stage (T3-T4) colorectal carcinomas by correlating MRI with histopathological findings. MATERIALS AND METHODS: The study population comprised 31 patients with 32 lesions (22 colon and 10 rectal carcinomas). The relationship between the tumor and bowel layers on T2- and contrast-enhanced T1-weighted images (T2WI, CE-T1WI), bowel wall deformity, and the linear architecture of subserosal fat on T2WI scans was independently assessed by two radiologists...
December 2016: Japanese Journal of Radiology
Makoto Sanomura, Shinji Tanaka, Yuichi Sasaki, Shinya Fukunishi, Kazuhide Higuchi
BACKGROUND/AIMS: We established a new colorectal T1 invasion depth sub-classification and evaluated it to determine whether total excisional biopsy can be performed on colorectal carcinoma (CRC) cases using narrow-band imaging (NBI) magnification. METHODS: The cases included 73 T1 carcinomas selected from 173 early CRC cases. The T1 invasion depth sub-classification was defined as follows: T1a, invasion less than 1,000 μm from the inferior border of the muscularis mucosae; T1b-1, between T1a and T1b-2; and T1b-2, T1b lesions with invasion from the deepest part of the carcinoma to within 1,000 μm of the superior border of the muscularis propria...
2016: Digestion
Takahide Shinagawa, Soichiro Ishihara, Hiroaki Nozawa, Koji Murono, Takeshi Nishikawa, Kensuke Otani, Kazuhito Sasaki, Koji Yasuda, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hironori Yamaguchi, Akimasa Hayashi, Mariko Tanaka, Tetsuo Ushiku, Masashi Fukayama, Toshiaki Watanabe
Colorectal cancer resembling submucosal tumor (SMT) is very rare. We herein report two cases of small colon carcinoma resembling SMT (80-year-old female and 67-year-old male), which massively invaded into the submucosal layer and accompanied marked lymphatic invasion and lymph node metastasis. We also reviewed the reported cases of colorectal carcinoma resembling SMT (SMT-like group, n=70) and analyzed the clinicopathological characteristics of this group compared with typical colorectal carcinoma cases operated at our institution (control group, n=1723)...
September 2, 2016: Clinics and Research in Hepatology and Gastroenterology
Manon van der Vlugt, Sascha Corrie van Doorn, Junfeng Wang, Barbara Aj Bastiaansen, Lowewijk Aa Brosens, Paul Fockens, Evelien Dekker
BACKGROUND AND STUDY AIMS: As colorectal cancer screening programs are being implemented worldwide, an increasing number of early (T1) cancers are being diagnosed. These cancers should be recognized during colonoscopy because they require a specific therapeutic approach. Several studies have shown that Asian experts can reliably recognize T1 cancers during colonoscopy. In daily practice, however, accurate endoscopic diagnosis of T1 cancers still seems challenging. We evaluated the performance of optical diagnosis of T1 cancers by European colonoscopy experts, general gastroenterologists and gastrointestinal fellows...
July 2016: Endoscopy International Open
Kenichi Takeda, Shin-Ei Kudo, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Kenta Kodama, Kunihiko Wakamura, Hideyuki Miyachi, Eiji Hidaka, Fumio Ishida, Haruhiro Inoue
BACKGROUND AND AIM: Permeation of a vein or lymphatic vessel by a tumor is a key risk factor for lymph node metastasis. We examined the features of colorectal tumor vessel permeation using endocytoscopy, an ultra-high magnifying endoscopic system combined with a narrow-band imaging capability (EC-NBI). PATIENTS AND METHODS: We examined 188 colorectal lesions using EC-NBI before treatment was started. We measured the diameters of tumor vessels on EC-NBI images. We used the tumor vessel diameter (the mean diameter of four tumor-associated vessels) and the variation in tumor vessel caliber (the difference between the maximum and minimum diameters of the vessels expressed as a proportion) to judge changes in vessel formation...
April 2016: Endoscopy International Open
Donghan Cai, Guoxian Guan, Xing Liu, Weizhong Jiang, Zhifen Chen
OBJECTIVE: To investigate the pattern of lymph node metastasis in patients with left-sided colon cancer in order to provide evidences for the choice of operation mode and the range of lymph node clearance. METHODS: Clinical data of 556 cases with left-sided colon carcinoma undergoing surgical treatment in Department of Colorectal Surgery, Fujian Medical University Union Hospital from January 2000 to October 2014 were retrospectively analyzed. Among these patients, cancer of splenic flexure and transverse colon close to splenic flexure (splenic flexure group) was found in 41 cases, descending colon cancer in 73 cases(descending colon goup) and sigmoid colon cancer in 442 cases (sigmoid colon group), respectively; T1 was found in 29 cases, T2 in 63 cases, T3 in 273 cases, T4 in 191 cases...
June 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Naoki Asayama, Shiro Oka, Shinji Tanaka, Daiki Hirano, Kyoku Sumimoto, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
We present a rare case of colorectal T1 carcinoma with metastasis of previous lung carcinoma found at the deepest invasive portion. A 61-year-old man presented with cervical lymphadenopathy 18 years after undergoing surgery for right lung carcinoma [poorly differentiated adenocarcinoma stage IIb (T3N0M0)]. Contrast-enhanced computed tomography showed enlarged lymph nodes (LNs) in the neck and mediastinal regions. Combined hybrid-F-fluorodeoxyglucose positron emission-computerized tomography showed increased radionuclide uptake in multiple cervical LNs and mediastinal LNs...
August 2016: Clinical Journal of Gastroenterology
Name Name, Teeranut Boonpipattanapong, Anuwat Palanusont, Wanwisa Maneechay, Surasak Sangkhathat
BACKGROUND: There is an established link between obesity related metabolic derangement and colorectal cancer development. Recently, we developed a metabolic-colorectal cancer risk score. In this follow-up study, we studied its association with colorectal neoplasm by measuring two major metabolic syndrome biomarkers, leptin and adiponectin. OBJECTIVES: To evaluate the serum levels of leptin and adiponectin in patients with colorectal polyps and colorectal cancer and to determine any correlation with metabolic risk score...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Naoki Asayama, Shiro Oka, Shinji Tanaka, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Hiroyuki Egi, Takao Hinoi, Hideki Ohdan, Koji Arihiro, Kazuaki Chayama
PURPOSE: Long-term outcomes of patients with T1 colorectal carcinoma (CRC) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among patients with T1 CRC in relation to the treatment methods. METHODS: We examined 322 T1 CRC cases treated between January 1992 and August 2008 at Hiroshima University Hospital...
March 2016: International Journal of Colorectal Disease
Hideyuki Miyachi, Shin-Ei Kudo, Katsuro Ichimasa, Tomokazu Hisayuki, Hiromasa Oikawa, Shingo Matsudaira, Yuta Kouyama, Yui Jennifer Kimura, Masashi Misawa, Yuichi Mori, Noriyuki Ogata, Toyoki Kudo, Kenta Kodama, Takemasa Hayashi, Kunihiko Wakamura, Atsushi Katagiri, Toshiyuki Baba, Eiji Hidaka, Fumio Ishida, Kenichi Kohashi, Shigeharu Hamatani
BACKGROUND AND AIM: Recent advances in endoscopic technology have allowed many T1 colorectal carcinomas to be resected endoscopically with negative margins. However, the criteria for curative endoscopic resection remain unclear. We aimed to identify risk factors for nodal metastasis in T1 carcinoma patients and hence establish the indication for additional surgery with lymph node dissection. METHODS: Initial or additional surgery with nodal dissection was performed in 653 T1 carcinoma cases...
June 2016: Journal of Gastroenterology and Hepatology
Ying-Kun Ren, Yan Xiao, Xiang-Bin Wan, Yu-Zhou Zhao, Jian Li, Yin Li, Guang-Sen Han, Xiao-Bing Chen, Qi-Yun Zou, Gang-Cheng Wang, Chao-Min Lu, Yong-Chao Xu, You-Cai Wang
Long non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA HOTTIP (HOXA transcript at the distal tip) in colorectal cancer (CRC) patients. This study attempted to investigate the association of lncRNA HOTTIP expression with progression and prognosis in CRC patients. LncRNA HOTTIP expression was measured in 156 CRC tissues and 21 adjacent non-malignant tissues using qRT-PCR. In present study, our results indicated that lncRNA HOTTIP was highly expressed in CRC compared with adjacent non-malignant tissues (P<0...
2015: International Journal of Clinical and Experimental Pathology
A Chino, N Yamamoto, Y Kato, K Morishige, H Ishikawa, T Kishihara, J Fujisaki, Y Ishikawa, Y Tamegai, M Igarashi
BACKGROUND AND AIM: Sessile serrated adenoma/polyps (SSAPs) are suspected to have a high malignant potential, although few reports have evaluated the incidence of carcinomas derived from SSAPs using the new classification for serrated polyps (SPs). The aim of study was to compare the frequency of cancer coexisting with the various SP subtypes including mixed polyps (MIXs) and conventional adenomas (CADs). METHODS: A total of 18,667 CADs were identified between April 2005 and December 2011, and 1858 SPs (re-classified as SSAP, hyperplastic polyp (HP), traditional serrated adenoma (TSA), or MIX) were removed via snare polypectomy, endoscopic mucosal resection, or endoscopic sub-mucosal dissection...
February 2016: International Journal of Colorectal Disease
F Bianco, A Arezzo, F Agresta, C Coco, R Faletti, Z Krivocapic, G Rotondano, G A Santoro, N Vettoretto, S De Franciscis, A Belli, G M Romano
Early colon cancer (ECC) has been defined as a carcinoma with invasion limited to the submucosa regardless of lymph node status and according to the Royal College of Pathologists as TNM stage T1 NX M0. As the potential risk of lymph node metastasis ranges from 6 to 17% and the preoperative assessment of lymph node metastasis is not reliable, the management of ECC is still controversial, varying from endoscopic to radical resection. A meeting on recent advances on the management of colorectal polyps endorsed by the Italian Society of Colorectal Surgery (SICCR) took place in April 2014, in Genoa (Italy)...
October 2015: Techniques in Coloproctology
H W Jiang, J Wang, H J Li, J K Peng, X P Gao, F Chen
This study investigated the effects of stable transfection of the exogenous wild-type DCC gene on growth of the human colorectal carcinoma cell line SW1116 in vitro. The DCC gene was amplified from normal human colon tissue by reverse transcription-polymerase chain reaction and used to construct a recombinant expression plasmid, pcDNA3.1(+)-DCC. DCC-negative SW1116 cells were transfected with pcDNA3.1(+)-DCC. Cell viability was tested by the methyl thiazolyl tetrazolium (MTT) assay. Immunofluorescence staining was used to determine the effects of pcDNA3...
2015: Genetics and Molecular Research: GMR
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