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https://www.readbyqxmd.com/read/28619309/scalp-acupuncture-attenuates-neurological-deficits-in-a-rat-model-of-hemorrhagic-stroke
#1
Hao Liu, Xiaowei Sun, Wei Zou, Mengtong Leng, Beng Zhang, Xiaoyu Kang, Tao He, Hui Wang
BACKGROUND: Hemorrhagic stroke accounts for approximately 15% of all stroke cases, and is associated with high morbidity and mortality. Limited human studies suggested that scalp acupuncture could facilitate functional recovery after cerebral hemorrhage. In the current study, we used an animal model of cerebral hemorrhage to examine the potential effects of scalp acupuncture. METHODS: Adult male Sprague-Dawley rats received autologous blood (50μL) into the right caudate nucleus on the right side under pentobarbital anesthesia, and then received scalp acupuncture (DU20 through GB7 on the lesion side) or sham acupuncture (1cm to the right side of the acupoints) (n=10 per group)...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28618657/antidepressive-effects-of-ginsenoside-rg1-via-regulation-of-hpa-and-hpg-axis
#2
Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic-pituitary-gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. OBJECTIVE: This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28615097/-protective-effect-of-quercetin-against-seawater-instillation-induced-acute-lung-injury-through-preventing-m1-polarization-of-macrophages-in-mice
#3
Baojian Wang, Xu Mao
Objective To study the protective effect of quercetin against seawater instillation-induced acute lung injury (SW-ALI) and explore the roles of M1polarization of macrophages and M1 macrophage-mediated inflammation in the protective effect. Methods Male C57BL/6 mice were randomly divided into four groups, normal control group, quercetin-treated group, SW-ALI group, SW-ALI and quercetin-treated group, with 15 mice in each group. The mice were intraperitoneally injected with 1 g/L pentobarbital sodium, and then seawater was injected into the lungs through oropharyngeal intubation at the concentration of 4 mL/kg...
June 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28596267/adaptations-of-motoneuron-properties-after-weight-lifting-training-in-rats
#4
Piotr Krutki, Włodzimierz Mrówczyński, Marcin Bączyk, Dawid Łochyński, Jan Celichowski
Resistance training, with repeated short-term and high-intensity exercises, is responsible for an increase in muscle mass and force. The aim of this study was to determine whether such training induces adaptations in the electrophysiological properties of motoneurons innervating the trained muscles and to relate these adaptive changes to previous observations made on motor unit contractile properties. The study was performed on adult male Wistar rats. Animals from the training group were subjected to a five-week voluntary progressive weight-lifting program, while control rats were restricted to standard cage activity...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28568894/intravital-investigation-of-rat-mesenteric-small-artery-tone-and-blood-flow
#5
Jakob Nyvad, Aleksandra Mazur, Dmitry D Postnov, Marthe Simonsen Straarup, Asger Maare Soendergaard, Christian Staehr, Emil Brøndum, Christian Aalkjaer, Vladimir V Matchkov
Functional characteristics of rat mesenteric small arteries (internal diameter ∼150-200 μm) have been extensively studied in vitro using isometric and isobaric myographs. In vivo, precapillary arterioles (internal diameter< 50 μm) have been studied, but only few studies have investigated the function of mesenteric small arteries. We here present a novel approach for intravital studies of rat mesenteric small artery segments (∼5 mm long) isolated in a chamber. The agonist-induced changes in arterial diameter and blood flow were studied using video imaging and laser speckle analysis in rats anaesthetized by isoflurane, pentobarbital, ketamine/xylazine, or by a combination of fentanyl, fluanison and midazolam (rodent mixture)...
June 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28535865/intraperitoneal-administration-of-ethanol-as-a-means-of-euthanasia-for-neonatal-mice-mus-musculus
#6
Cecilia de Souza Dyer, Angela K Brice, James O Marx
The humane euthanasia of animals in research is of paramount importance. Neonatal mice frequently respond differently to euthanasia agents when compared with adults. The AVMA's Guidelines for the Euthanasia of Animals includes intraperitoneal injection of ethanol as "acceptable with conditions," and recent work confirmed that this method is appropriate for euthanizing adult mice, but neonatal mice have not been tested. To explore this method in neonatal mice, mouse pups (C57BL/6 and CD1, 162 total) were injected with 100% ethanol, a pentobarbital-phenytoin combination, or saline at 7, 14, 21, 28, or 35 d of age...
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28524102/sleep-promoting-effects-and-possible-mechanisms-of-action-associated-with-a-standardized-rice-bran-supplement
#7
Hyejin Yang, Minseok Yoon, Min Young Um, Jaekwang Lee, Jonghoon Jung, Changho Lee, Yun-Tai Kim, Sangoh Kwon, Boknam Kim, Suengmok Cho
Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran-a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28509855/the-hypnotic-anxiolytic-and-antinociceptive-profile-of-a-novel-%C3%A2%C2%B5-opioid-agonist
#8
Guilherme Carneiro Montes, Bianca Nascimento Monteiro da Silva, Bismarck Rezende, Roberto Takashi Sudo, Vitor Francisco Ferreira, Fernando de Carvalho da Silva, Angelo da Cunha Pinto, Bárbara Vasconcellos da Silva, Gisele Zapata-Sudo
5'-4-Alkyl/aryl-1H-1,2,3-triazole derivatives PILAB 1-12 were synthesized and a pharmacological screening of these derivatives was performed to identify a possible effect on the Central Nervous System (CNS) and to explore the associated mechanisms of action. The mice received a peritoneal injection (100 µmol/kg) of each of the 12 PILAB derivatives 10 min prior to the injection of pentobarbital and the mean hypnosis times were recorded. The mean hypnosis time increased for the mice treated with PILAB 8, which was prevented when mice were administered CTOP, a µ-opioid antagonist...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28508339/induction-of-hibernation-like-hypothermia-by-central-activation-of-the-a1-adenosine-receptor-in-a-non-hibernator-the-rat
#9
Hiroki Shimaoka, Takayuki Kawaguchi, Kahori Morikawa, Yuuki Sano, Kiyotada Naitou, Hiroyuki Nakamori, Takahiko Shiina, Yasutake Shimizu
Central adenosine A1-receptor (A1AR)-mediated signals play a role in the induction of hibernation. We determined whether activation of the central A1AR enables rats to maintain normal sinus rhythm even after their body temperature has decreased to less than 20 °C. Intracerebroventricular injection of an adenosine A1 agonist, N6-cyclohexyladenosine (CHA), followed by cooling decreased the body temperature of rats to less than 20 °C. Normal sinus rhythm was fundamentally maintained during the extreme hypothermia...
May 15, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28499795/anesthesia-inducing-drugs-also-induce-conditioned-taste-aversions
#10
Jian-You Lin, Joe Arthurs, Steve Reilly
Animals learn to reduce their intake of a tastant when its ingestion is followed by the administration of an anesthesia-inducing drug. To determine the nature of this intake suppression, the current study examined whether ketamine/xylazine (Experiment 1) and pentobarbital (Experiment 2) also conditionally reduce taste palatability. Using lick pattern analysis, we found that pairing saccharin with either drug reduced total licks, lick cluster size, and initial lick rate. Given that both lick cluster size and initial lick rate are indices of palatability, this pattern of results indicates that anesthesia-inducing drugs also induce conditioned taste aversions...
May 9, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28491857/administration-of-zinc-against-arsenic-induced-nephrotoxicity-during-gestation-and-lactation-in-rat-model
#11
Davood Nasiry Zarrin Ghabaee, Fereshteh Talebpour Amiri, Amir Esmaeelnejad Moghaddam, Ali Reza Khalatbary, Mehryar Zargari
BACKGROUND: Free radicals production by toxicity of arsenic (Ar) is most important in the nephrotoxicity. There is accumulating evidence that zinc (Zn), has anti-oxidant properties. OBJECTIVES: The aim of present study was to evaluate protective and ameliorative effects of Zn against Ar-induced nephrotoxicity in rat pups during gestation and lactation. MATERIALS AND METHODS: Twenty-four adult pregnant wistar rats were randomly divided into four groups (n = 6)...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28491111/ficus-hispida-bark-extract-prevents-nociception-inflammation-and-cns-stimulation-in-experimental-animal-model
#12
Md Sariful Islam Howlader, Md Afjalus Siraj, Shubhra Kanti Dey, Arpona Hira, Arif Ahmed, Md Hemayet Hossain
Background. Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). Methods. The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28486854/xylastriasan-a-a-new-cytochalasan-from-the-fungus-xylaria-striata
#13
Chuan-Wen Lei, Zhi-Qin Yang, Yan-Ping Zeng, Yun Zhou, Yi Huang, Xin-Sheng He, Guo-You Li, Xiao-Hong Yuan
Xylastriasan A (1), a new cytochalasan alkaloid with a rare 5/6/6/5/6 pentacyclic skeleton, and ergosterol (2) were isolated from the ethanol extract of fruiting bodies of the fungus Xylaria striata. Their structures were determined by analysis of their spectroscopic data. Compound 1 exhibited weak cytotoxic activity against HEPG2, B16 and A549 cell lines with IC50 values of 93.61, 85.61 and 91.58 μM, respectively. Ergosterol (2) potentiated pentobarbital-induced sleep by not only increasing the number of falling asleep and prolonging sleeping time but also reducing sleep latency at a dosage of 5 mg/kg...
May 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28462721/the-expression-and-purification-of-the-delta-sleep-inducing-peptide-fused-with-protein-transduction-domain-and-human-serum-albumin-in-pichia-pastoris
#14
Xin-Guo Zhang, Wen-Na Wang, Chun-Sheng Zhang, Kun Li, Guo-Di Ma, Jian-Yong Li
Delta sleep-inducing peptide (DSIP) is a nonapeptide that could promote sleep through the induction of slow wave sleep. To further study the pharmacological effect of DSIP on insomnia, we designed a fusion protein containing N-terminal TAT-based transduction domain followed by human serum albumin and DSIP and designated this protein as PHD fusion protein. We expressed PHD fusion protein in Pichia pastoris, purified it to near homogeneity by three-step chromatography and performed bioactivity assay. The pharmacological activity of PHD fusion protein was studied using classic pentobarbital-induced sleep test in healthy mice...
April 25, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28459715/biphasic-renal-sympathetic-response-to-hemorrhagic-hypotension-in-mice
#15
Tao Zhang, Mamoru Tanida, Kunitoshi Uchida, Yoshiro Suzuki, Wei Yang, Yuhichi Kuda, Yasutaka Kurata, Makoto Tominaga, Toshishige Shibamoto
AIM: The inhibitory responses of renal sympathetic nerve activity (RSNA) and heart rate (HR) to sustained hemorrhagic shock occurred in anesthetized rats, but have not yet been determined in mice. Here, we investigated the responses of RSNA and HR to hemorrhagic hypotension in anesthetized mice, with an emphasis on the molecule-based mechanism for roles of afferent vagal nerves. METHODS: RSNA, HR, and mean systemic arterial pressure (MAP) were continuously measured in male pentobarbital-anesthetized C57BL/6N mice...
April 28, 2017: Shock
https://www.readbyqxmd.com/read/28457510/pattern-recognition-analysis-of-proton-nuclear-magnetic-resonance-spectra-of-postmortem-cerebrospinal-fluid-from-rats-with-drug-induced-seizure-or-coma
#16
Yoshimasa Kanawaku, Keiko Hirakawa, Kaoru Koike, Jun Kanetake, Youkichi Ohno
Cerebrospinal fluid (CSF) is routinely subjected to gross evaluation in postmortem investigations; however, its use in chemical evaluations has not been fully realized. Analysis of nuclear magnetic resonance (NMR) spectra with pattern recognition methods was applied to CSF samples. Rats were treated with pentylenetetrazol (PTZ) to induce seizure or pentobarbital (PB) to induce coma, and postmortem CSF was collected after CO2 gas euthanization. Pattern recognition analysis of the NMR data was performed on individual postmortem CSF samples...
March 2017: Legal Medicine
https://www.readbyqxmd.com/read/28429678/intraperitoneal-administration-of-ethanol-as-a-means-of-euthanasia-for-neonatal-mice-mus-musculus
#17
Cecilia de Souza Dyer Angela K Brice And James O Marx
The humane euthanasia of animals in research is of paramount importance. Neonatal mice frequently respond differentlyto euthanasia agents when compared with adults. The AVMA's Guidelines for the Euthanasia of Animals includes intraperitonealinjection of ethanol as "acceptable with conditions," and recent work confirmed that this method is appropriate for euthanizing adult mice, but neonatal mice have not been tested. To explore this method in neonatal mice, mouse pups(C57BL/6 and CD1, 162 total) were injected with 100% ethanol, a pentobarbital-phenytoin combination, or saline at 7, 14, 21, 28, or 35 d of age...
April 20, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28424774/cardiac-radionuclide-imaging-in-rodents-a-review-of-methods-results-and-factors-at-play
#18
Francesco Cicone, David Viertl, Ana Maria Quintela Pousa, Thibaut Denoël, Silvano Gnesin, Francesco Scopinaro, Marie-Catherine Vozenin, John O Prior
The interest around small-animal cardiac radionuclide imaging is growing as rodent models can be manipulated to allow the simulation of human diseases. In addition to new radiopharmaceuticals testing, often researchers apply well-established probes to animal models, to follow the evolution of the target disease. This reverse translation of standard radiopharmaceuticals to rodent models is complicated by technical shortcomings and by obvious differences between human and rodent cardiac physiology. In addition, radionuclide studies involving small animals are affected by several extrinsic variables, such as the choice of anesthetic...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28421845/an-alarming-increase-in-local-pentobarbital-related-suicides
#19
F Lee Cantrell, Iain M McIntyre
No abstract text is available yet for this article.
June 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28413325/the-psychopharmacological-activities-of-vietnamese-ginseng-in-mice-characterization-of-its-psychomotor-sedative-hypnotic-antistress-anxiolytic-and-cognitive-effects
#20
Irene Joy I Dela Peña, Hee Jin Kim, Chrislean Jun Botanas, June Bryan de la Peña, Thi Hong Van Le, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon Cheong
BACKGROUND: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. METHODS: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects...
April 2017: Journal of Ginseng Research
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