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https://www.readbyqxmd.com/read/29763644/immunomodulatory-effect-of-celecoxib-on-hmgb1-tlr4-pathway-in-a-recurrent-seizures-model-in-immature-rats
#1
Mariana Morales-Sosa, Sandra Orozco-Suárez, AngélicaVega-García, Sara Caballero-Chacón, Iris A Feria-Romero
Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such as neuroinflammation. Those mechanisms of response activate inflammatory molecules induced in the neurons, activated glial cells and endothelial cells via the key HMGB1/TLR4 pathway. In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways...
May 12, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29746397/impact-of-drug-interactions-on-clobazam-and-n-desmethylclobazam-concentrations-in-pediatric-patients-with-epilepsy
#2
Gabrielle R Russell, Stephanie J Phelps, Chasity M Shelton, James W Wheless
BACKGROUND: Clobazam (CLB) is approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients ≥2 years of age. It is converted to an active metabolite N-desmethylclobazam (NCLB) by CYP3A4, which is then broken down to an inactive metabolite by CYP2C19. This study characterizes the impact of CYP3A4 and CYP2C19 drug interactions on CLB and NCLB serum concentrations (Cp) and concentration/dose (Cp/D) ratios in pediatric patients with epilepsy. METHODS: This was a retrospective chart review including patients >1 month of age, who received CLB between April 2012 and March 2017...
May 4, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29727217/arteriolar-vasodilation-involves-actin-depolymerization
#3
Philip S Clifford, Brian S Ferguson, Jeffrey L Jasperse, Michael A Hill
It is generally assumed that relaxation of arteriolar vascular smooth muscle occurs through hyperpolarization of the cell membrane, reduction in intracellular calcium concentration, and activation of myosin light chain phosphatase/inactivation of myosin light chain kinase. We hypothesized that vasodilation is related to depolymerization of F-actin. Cremaster muscles were dissected from rats under sodium pentobarbital anesthesia (50mg/kg). 1A arterioles were dissected, cannulated on glass micropipettes, pressurized, and warmed to 34{degree sign}C...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29724623/mechanism-of-interleukin-1-receptor-antagonist-protection-against-myocardial-ischaemia-reperfusion-induced-injury
#4
Wenhao Qian, Changyun Zhao, Dongye Li, Rui Dai
BACKGROUND: New therapeutic targets are required for ischaemic heart disease; our study was designed to assess the theoretical foundation and experimental basis underlying the use of a new anticytokine agent, interleukin-1 receptor antagonist (IL-1ra), in this setting. AIM: To investigate the cardioprotective properties of IL-1ra in terms of inhibition of apoptosis and improvement in systolic and diastolic functions of ischaemia/reperfusion (I/R)-injured cardiomyocytes, via a reduction in the inositol 1,4,5-trisphosphate (IP3) receptor-mediated Ca2+ overload induced by myocardial I/R injury...
April 30, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29710491/valerian-cascade-mixture-promotes-sleep-by-increasing-non-rapid-eye-movement-nrem-in-rodent-model
#5
Hyeon-Son Choi, Ki-Bae Hong, Sung Hee Han, Hyung Joo Suh
The aim of this study was to investigate the beneficial effect of Valerian/Cascade mixture on sleeping in mammal models. In pentobarbital-induced sleep model, Valerian, Cascade, and Valerian/Cascade mixture significantly reduced the latency time for sleeping, and total sleeping time effectively increased in these sample groups compared with the control. Valerian/Cascade mixture increased sleep duration by 37%. The mixture significantly increased the non-rapid eye movement (NREM) sleep time by 53% compared with the control, while REM sleeping time was decreased by 33% with Valerian/Cascade mixture, in Electroencephalography (EEG) analysis, resulting in the increase of total sleep time and the decrease of awakening...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29695101/triphlorethol-a-a-dietary-polyphenol-from-seaweed-decreases-sleep-latency-and-increases-non-rapid-eye-movement-sleep-in-mice
#6
Minseok Yoon, Suengmok Cho
In our previous studies, we have demonstrated that marine polyphenol phlorotannins promote sleep through the benzodiazepine site of the gamma-aminobutyric acid type A (GABAA ) receptors. In this follow-up study, the sleep-promoting effects of triphlorethol A, one of the major phlorotannin constituents, were investigated. The effect of triphlorethol A on sleep-wake architecture and profiles was evaluated based on electroencephalogram and electromyogram data from C57BL/6N mice and compared with the well-known hypnotic drug zolpidem...
April 24, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29677536/sedative-and-hypnotic-effects-of-schisandrin-b-through-increasing-gaba-glu-ratio-and-upregulating-the-expression-of-gaba-a-in-mice-and-rats
#7
Ning Li, Jiale Liu, Mengyang Wang, Zepeng Yu, Kuo Zhu, Jiaqi Gao, Chunmei Wang, Jinghui Sun, Jianguang Chen, He Li
Schisandrin B (SchB) is an active lignan component from Schisandra chinensis Turcz. Baill that has been long used as Traditional Chinese Medical Herb in the prescriptions for "tranquilizing the mind and overcoming anxiety". Given that SchB is one of the most abundant ingredients of Schisandra chinensis Baill, we examined the sedative and hypnotic effects of SchB and explored the underlying mechanism. The results showed that SchB can significantly decrease mouse locomotor activities and improved sleeping quality index, including increased number of sleeping mice treated with the subthreshold dose of pentobarbital sodium, increased sleep time, shortened sleep latency and prolonged sleep duration...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29657508/hypnotic-effect-of-red-cabbage-brassica-oleracea-on-pentobarbital-induced-sleep-in-mice
#8
Azar Hosseini, Mohammad-Ali Sobhanifar, Fatemeh Forouzanfar, Azita Aghaee, Hassan Rakhshandeh
Objective: The present study was performed to investigate the effect of hydroalcoholic extract of red cabbage and its fractions on sleeping behavior in mice. Materials and Methods: The extract and its fractions were injected to mice and sleep duration as well as sleep latency were recorded. Furthermore, toxicity of the extract was determined both in vivo and in vitro . Results: The extract increased sleep duration at doses of 50-200mg/kg ( P < 0...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29655484/oral-pentobarbital-suspension-for-children-sedation-during-mr-imaging
#9
J Schlatter, S Kabiche, N Sellier, J-E Fontan
OBJECTIVES: The efficacy and safety of an oral pentobarbital suspension for sedation during pediatric MR imaging were assessed. METHODS: Data were recorded from October 2016 to January 2017. The exact dose of oral pentobarbital suspension was given for each child with an oral syringe. Parameters recorded included the patient's age and weight, the time required to sedate, the duration of sedation, the time required to discharge, and quality of MR imaging. The adverse effects were recorded...
April 11, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29629959/baseline-cerebral-metabolic-rate-is-a-critical-determinant-of-the-cerebral-vasodilating-potency-of-volatile-anesthetic-agents
#10
John C Drummond
Halothane is commonly viewed as a more potent cerebral vasodilator than isoflurane. It was speculated that the lesser vasodilation caused by isoflurane might be the result of the greater reduction in cerebral metabolic rate (CMR) that it causes, and that the relative vasodilating potencies of halothane and isoflurane would be similar if the two agents were administered in a situation that precluded volatile-agent-induced depression of CMR. To test this hypothesis, cerebral blood flow (CBF) and the cerebral metabolic rate for oxygen (CMRO2) were measured in two groups of rabbits before and after the administration of 0...
April 9, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29617295/the-effects-of-deoxynivalenol-and-zearalenone-on-the-pig-large-intestine-a-light-and-electron-microscopy-study
#11
Barbara Przybylska-Gornowicz, Bogdan Lewczuk, Magdalena Prusik, Maria Hanuszewska, Marcela Petrusewicz-Kosińska, Magdalena Gajęcka, Łukasz Zielonka, Maciej Gajęcki
The contamination of feed with mycotoxins results in reduced growth, feed refusal, immunosuppression, and health problems. Deoxynivalenol (DON) and zearalenone (ZEN) are among the most important mycotoxins. The aim of the study was to examine the effects of low doses of these mycotoxins on the histological structure and ultrastructure of the large intestine in the pig. The study was performed on 36 immature gilts of mixed breed (White Polish Big &times; Polish White Earhanging), which were divided into four groups administrated per os with ZEN at 40 &micro;g/kg BW, DON at 12 &micro;g/kg BW, a mixture of ZEN (40 &micro;g/kg BW) and DON (12 &micro;g/kg BW) or a placebo...
April 4, 2018: Toxins
https://www.readbyqxmd.com/read/29596325/preconditioning-like-properties-of-short-term-hypothermia-in-isolated-perfused-rat-liver-iprl-system
#12
Norma Alva, Raquel G Bardallo, David Basanta, Jesús Palomeque, Teresa Carbonell
Hypothermia may attenuate the progression of ischemia-induced damage in liver. Here, we determined the effects of a brief cycle of hypothermic preconditioning applied before an ischemic/reperfusion (I/R) episode in isolated perfused rat liver (IPRL) on tissue damage and oxidative stress. Rats (male, 200-250 g) were anaesthetised with sodium pentobarbital (60 mg·kg-1 i.p) and underwent laparatomy. The liver was removed and perfused in a temperature-regulated non-recirculating system. Livers were randomly divided into two groups ( n = 6 each group)...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29582225/outcomes-in-children-treated-with-pentobarbital-infusion-for-refractory-and-super-refractory-status-epilepticus
#13
Jennifer Erklauer, Jeanine Graf, Mona McPherson, Anne Anderson, Angus Wilfong, Charles G Minard, Laura Loftis
BACKGROUND: Functional neurologic outcome for children with refractory and super-refractory status epilepticus has not been well defined. METHODS: Retrospective chart review including children age 0-17 years who received pentobarbital infusion from 2003 to 2016 for status epilepticus. Outcomes were defined in terms of mortality, need for new medical technology assistance at hospital discharge and functional neurologic outcome determined by pediatric cerebral performance category score (PCPC)...
March 26, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29576175/50-years-ago-in-the-journal-of-pediatrics-the-effect-of-pretreatment-with-pentobarbital-meperidine-or-hyperbaric-oxygen-on-the-response-to-anoxia-and-resuscitation-in-newborn-rabbits
#14
https://www.readbyqxmd.com/read/29572847/sedative-hypnotic-and-anxiolytic-effects-and-the-mechanism-of-action-of-aqueous-extracts-of-peanut-stems-and-leaves-in-mice
#15
Lei Deng, Ai-Min Shi, Qiang Wang
Peanut stems and leaves (PSL) have traditionally been used as both a special food and herbal medicine in Asia. The sedative-hypnotic and anxiolytic effects of PSL have been recorded in classical traditional Chinese literature, and more recently, by many other researchers. In a previous study, four sleep-related ingredients (linalool, 5-Hydroxy-4', 7-dimethoxyflavanone, 2'-O-Methylisoliquiritigenin and ferulic acid), among which 5-Hydroxy-4', 7-dimethoxyflavanone, 2'-O-Methylisoliquiritigenin was newly found in the Arachis species, were screened using an Ultra Performance LC system coupled with quadrupole-time of flight mass spectrometry (UPLC-QTOF-MS)...
March 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29546795/a-new-animal-model-for-menopausal-transition-combination-of-ovariectomy-and-empty-bottle-stimulation
#16
Yang Ye, Cun-Zhi Liu, Rui Wang, Yu-Wei Zhang, Bo Zhang, Yu Cui, Xue-Wei Liu, Shu-Ming Huang
Previous small animal models for menopausal transition are mainly performed to mimic the biochemical changes of patients with menopausal transition. The psychological symptoms in animal models are often overlooked. To mimic clinical situation, we developed a new mouse model of menopausal transition: the combination of bilateral ovariectomy (OVX) and empty bottle stimulation (EBS). After OVX and 21 days of EBS, behavioral test and pentobarbital-induced sleep test were carried out. Then all the animals were euthanized for further investigations...
March 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29545209/chemical-characterization-pharmacological-effects-and-toxicity-of-an-ethanol-extract-of-celtis-pallida-torr-cannabaceae-aerial-parts
#17
Edgar Isaac Rojas-Bedolla, Jorge Luis Gutiérrez-Pérez, Mario Iván Arenas-López, Marco Martin González-Chávez, Juan Ramón Zapata-Morales, Claudia Leticia Mendoza-Macías, Candy Carranza-Álvarez, Juan José Maldonado-Miranda, Martha Alicia Deveze-Álvarez, Angel Josabad Alonso-Castro
ETHNOPHARMACOLOGICAL RELEVANCE: Celtis pallida Torr (Cannabaceae) is employed as a folk medicine for the treatment of inflammation, pain, skin infections, and diarrhea, among other diseases. AIM OF THE STUDY: The purpose of this work was to assess the chemical composition, the in vitro and in vivo toxicity, the antimicrobial, anti-inflammatory, antidiarrheal, antinociceptive, locomotor, and sedative effects of an ethanolic extract obtained from Celtis pallida aerial parts (CPE)...
March 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29521239/hypnotic-effect-of-portulaca-oleracea-l-on-pentobarbital-induced-sleep-in-mice
#18
Shokouhsadat Hamedi, Fatemeh Forouzanfar, Hasan Rakhshandeh, Amirali Arian
OBJECTIVE: In Iranian Traditional Medicine, the herbs with cold and wet temperament can help to improve insomnia. Portulaca oleracea has cold and wet temperament, so the present study was carried out to investigate the sleep-prolonging effect of Portulaca oleracea. METHODS: This work was an experimental study on mice which were randomly divided into these groups: saline (control); Diazepam:) positive control); hydro-alcoholic extract of Portulaca oleracea (12.5, 25, 50, 75 and 100 mg/kg) by Soxhlet apparatus and maceration; in the effective (dose25 mg/kg), different fractions of extract were tested...
March 8, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29507852/pitfall-in-pupillometry-exaggerated-ciliospinal-reflex-in-a-patient-in-barbiturate-coma-mimicking-a-nonreactive-pupil
#19
Naresh Mullaguri, Nakul Katyal, Aarti Sarwal, Jonathan M Beary, Pravin George, Naresh Karthikeyan, Premkumar Nattanamai, Christopher R Newey
Although a neurological examination is fundamental to the evaluation of comatose patients, it is less reliable in a medically induced coma. A commonly misinterpreted finding in patients in a pentobarbital coma is altered pupillary reactivity secondary to an exaggerated ciliospinal reflex. Recognizing an exaggerated ciliospinal reflex in patients in a pentobarbital coma is important and may prevent unnecessary intervention. We present a patient induced in a pentobarbital coma for the treatment of status epilepticus who exhibited a nonreactive pupil secondary to an exaggerated ciliospinal reflex confirmed by pupillometry...
December 30, 2017: Curēus
https://www.readbyqxmd.com/read/29506906/application-of-unfolding-transformation-in-the-random-matrix-theory-to-analyze-in-vivo-neuronal-spike-firing-during-awake-and-anesthetized-conditions
#20
Risako Kato, Masanori Yamanaka, Masayuki Kobayashi
General anesthetics decrease the frequency and density of spike firing. This effect makes it difficult to detect spike regularity. To overcome this problem, we developed a method utilizing the unfolding transformation which analyzes the energy level statistics in the random matrix theory. We regarded the energy axis as time axis of neuron spike and analyzed the time series of cortical neural firing in vivo. Unfolding transformation detected regularities of neural firing while changes in firing densities were associated with pentobarbital...
March 2018: Journal of Pharmacological Sciences
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