Julia-Annabell Georgi, Sebastian Stasik, Michael Kramer, Manja Meggendorfer, Christoph Röllig, Torsten Haferlach, Peter Valk, David Linch, Tobias Herold, Nicolas Duployez, Franziska Taube, Jan Moritz Middeke, Uwe Platzbecker, Hubert Serve, Claudia D Baldus, Carsten Muller-Tidow, Claudia Haferlach, Sarah Koch, Wolfgang E Berdel, Bernhard J Woermann, Utz Krug, Jan Braess, Wolfgang Hiddemann, Karsten Spiekermann, Emma L Boertjes, Robert K Hills, Alan Burnett, Gerhard Ehninger, Klaus Metzeler, Maja Rothenberg-Thurley, Annika Dufour, Hervé Dombret, Cecile Pautas, Claude Preudhomme, Laurene Fenwarth, Martin Bornhäuser, Rosemary Gale, Christian Thiede
Despite recent refinements in the diagnostic and prognostic assessment of CEBPA mutations in AML, several questions remain open, i.e. implications of different types of basic region leucin zipper (bZIP) mutations, the role of co-mutations and the allelic state. Using pooled primary data analysis on 1010 CEBPA-mutant adult AML patients, a comparison was performed taking into account the type of mutation (bZIP: either typical in-frame insertion/deletion (InDel) mutations (bZIPInDel ), frameshift InDel or nonsense mutations inducing translational stop (bZIPSTOP ) or single base-pair missense alterations (bZIPms ), and transcription activation domain (TAD) mutations) and the allelic state (single (smCEBPA) vs...
January 16, 2024: Leukemia