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https://www.readbyqxmd.com/read/29775939/biodegradation-in-seawater-of-pah-and-alkylphenols-from-produced-water-of-a-north-sea-platform
#1
Synnøve Lofthus, Inger K Almås, Peter Evans, Oliver Pelz, Odd Gunnar Brakstad
Operational planned discharges of produced water (PW) to the marine environment from offshore oil production installations, contain low concentrations of dispersed oil compounds, like polycyclic aromatic hydrocarbons (PAHs) and alkylated phenols (APs). Biotransformation in natural seawater (SW) of naphthalenes/PAHs and phenol/APs in field-collected PW from a North Sea platform was investigated in this biodegradation study. The PW was diluted in SW from a Norwegian fjord, and the biodegradation study was performed in slowly rotating carousels at 13 °C over a period of 62 days...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29775593/structure-of-telomerase-with-telomeric-dna
#2
Jiansen Jiang, Yaqiang Wang, Lukas Sušac, Henry Chan, Ritwika Basu, Z Hong Zhou, Juli Feigon
Telomerase is an RNA-protein complex (RNP) that extends telomeric DNA at the 3' ends of chromosomes using its telomerase reverse transcriptase (TERT) and integral template-containing telomerase RNA (TER). Its activity is a critical determinant of human health, affecting aging, cancer, and stem cell renewal. Lack of atomic models of telomerase, particularly one with DNA bound, has limited our mechanistic understanding of telomeric DNA repeat synthesis. We report the 4.8 Å resolution cryoelectron microscopy structure of active Tetrahymena telomerase bound to telomeric DNA...
May 17, 2018: Cell
https://www.readbyqxmd.com/read/29775321/direct-ortho-c-h-aminoalkylation-of-2-substituted-pyridine-derivatives-catalyzed-by-yttrium-complexes-with-n-n-diarylethylenediamido-ligands
#3
Abhinanda Kundu, Mariko Inoue, Haruki Nagae, Hayato Tsurugi, Kazushi Mashima
A mixed ligated amidoyttrium complex, Y(NBn2 )(L1)(THF)2 (8, L1 = N,N'-bis(2,6-diisopropylphenyl)ethylenediamine), served as a catalyst for addition of the ortho-pyridyl C(sp2 )-H bond of 2-substituted pyridines to non-activated imines; complex 8 showed superior catalytic performance compared with Y[N(SiMe3 )2 ]3 (1) and Y[N(SiMe3 )2 ]2 (NBn2 )(THF) (2). Concerning the reaction mechanism, we conducted a stoichiometric reaction of an alkylyttrium complex, Y(CH2 SiMe3 )(L1)(THF)2 (7), with 2-ethylpyridine (4e), giving a mixture of (η3 -pyridylmethyl)yttrium complex 9 and (η2 -pyridyl)yttrium complex 10 along with elimination of SiMe4 ...
May 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29774145/evaluation-of-attenuative-effect-of-tert-butylhydroquinone-against-diazinon-induced-oxidative-stress-on-hematological-indices-in-male-wistar-rats
#4
Saman Sargazi, Hamidreza Galavi, Sadegh Zarei
Diazinon is an organophosphate toxicant that has been identified to induce oxidative stress within biological systems through altering biochemical and hematological indices, by generating free radicals while deteriorating the cellular antioxidant defense system. The present study was designed to evaluate the effectiveness of tert-butylhydroquinone (TBHQ), a synthetic food additive, in serving as an antioxidant against sub-lethal diazinon-induced oxidative stress in male Wistar rats. Animals were randomly divided into 4 groups: Control (treated with corn oil as a vehicle), diazinon (10 mg/kg/day), TBHQ (0...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29772900/pyrene-fused-s-indacene
#5
Jason Melidonie, Junzhi Liu, Yubin Fu, Jan J Weigand, Reinhard Berger, Xinliang Feng
One antiaromatic polycyclic hydrocarbon (PH) with and without solubilizing tert-butyl substituents, namely s-indaceno[2,1- a:6,5- a']dipyrene (IDPs), has been synthesized by a four-step protocol. The IDPs represent the longitudinal, peri-extension of the indeno[1,2- b]fluorene skeleton towards a planar 40 π-electron system. Their structures were unambiguously confirmed by X-ray crystallographic analysis. The optoelectronic properties were studied by UV/Vis absorption spectroscopy and cyclic voltammetry. These studies revealed that peri-fusion renders the IDP derivatives with a narrow optical energy gap of 1...
May 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29772520/-valeriana-wallichii-extract-inhibits-tert-booh-induced-oxidative-damage-and-cytotoxicity
#6
Vishal Jain, Ruma Dutta, Doddamane Thippeswamy Maheshwari, Darmendra Kumar Meena, Kshipra Misra, Mysore Sadashiva Yogendra Kumar
Oxidative s tress is well known to be involved in pathophysiology of several disorders. Valeriana wallichii (VW) root extracts is known for its expedient activities but its antioxidant and cytoprotective efficacy need to be explored further. In present study tertiary-butyl hydroperoxide (tert-BOOH) was used to induce oxidative stress in C6 glioma cells. Antioxidant activity of the VW root extracts were evaluated by chemical assays i.e . DPPH, ABTS and FRAP assay. Further effect of VW on tert-BOOH induced oxidative stress and mitochondrial damage was studied...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29769246/small-molecule-positive-allosteric-modulators-of-the-%C3%AE-2-adrenoceptor-isolated-from-dna-encoded-libraries
#7
Seungkirl Ahn, Biswaranjan Pani, Alem W Kahsai, Eva K Olsen, Gitte Husemoen, Mikkel Vestrgaard, Lei Jin, Shuai Zhao, Laura M Wingler, Paula K Rambarat, Rishabh K Simhal, Thomas T Xu, Lillian D Sun, Paul J Shim, Dean P Staus, Li-Yin Huang, Thomas Franch, Xin Chen, Robert J Lefkowitz
Conventional drug discovery efforts at the β2 -adrenoceptor (β2 AR) have led to the development of ligands that bind almost exclusively to the receptor's hormone-binding orthosteric site. However, targeting the largely unexplored and evolutionarily unique allosteric sites has potential for developing more specific drugs with fewer side effects than orthosteric ligands. Using our recently developed approach for screening G protein-coupled receptors (GPCRs) with DNA-encoded small molecule libraries, we have discovered and characterized the first β2 AR small molecule positive allosteric modulators (PAMs) - compound-6 [(R)-N-(4-amino-1-(4-(tert-butyl)phenyl)-4-oxobutan-2-yl)-5-(N-isopropyl-N-methylsulfamoyl)-2-((4-methoxyphenyl) thio)benzamide] and its analogs...
May 16, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29767525/distribution-of-nanodiamond-inside-the-nanomatrix-in-natural-rubber
#8
Asangi Gannoruwa, Seiichi Kawahara
The distribution of nanodiamond inside a nanomatrix, which is related to the mechanical and viscoelastic properties, is investigated for a natural rubber-nanodiamond composite. The composite is prepared by reacting nanodiamond with deproteinized natural rubber (NR-ND) in the presence of a tert-butylhydroperoxide (TBHPO) / tetraethylenepentamine (TEPA) radical initiator at 30 °C in the latex stage and subsequent drying. The morphology of the composite is observed by 3D transmission electron microscopy (TEM)...
May 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29765763/crystal-structure-and-catalytic-activity-of-tetra-kis-%C3%AE-2-ethyl-2-6-di-tert-butyl-4-methyl-phenyl-phos-phato-%C3%AE%C2%BA-2-o-o-bis-ethyl-2-6-di-tert-butyl-4-methyl-phenyl-phosphato-%C3%AE%C2%BA-2-o-o-dilutetium-n-heptane-disolvate
#9
Mikhail E Minyaev, Alexander N Tavtorkin, Sof'ya A Korchagina, Ilya E Nifant'ev, Andrei V Churakov
The title complex, [Lu2 (C17 H28 O4 P)6 ]·2C7 H16 , was formed in the reaction between potassium 2,6-di- tert -butyl-4-methyl-phenyl ethyl phosphate, [K(2,6- t Bu2 -4-MeC6 H2 -O)(EtO)PO2 ], and LuCl3 (H2 O)6 in water, followed by vacuum drying and recrystallization from heptane. Its crystal structure has triclinic ( P [Formula: see text]) symmetry at 120 K. The lutetium tris-(phosphate) complex has a binuclear [Lu2 (μ-OPO)4 ] core and the organophosphate ligand exhibits κ2 O , O ' terminal and μ2 -κ1 O :κ1 O ' bridging coordination modes with the LuIII ion being sixfold coordinated...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765760/2-oxo-2-h-chromen-7-yl-4-tert-butyl-benzoate
#10
Mohammad Ouédraogo, Akoun Abou, Abdoulaye Djandé, Olivier Ouari, T Jérémie Zoueu
In the title compound, C20 H18 O4 , the benzoate ring is oriented at an acute angle of 33.10 (12)° with respect to the planar (r.m.s deviation = 0.016 Å) coumarin ring system. An intra-molecular C-H⋯O hydrogen bond closes an S (6) ring motif. In the crystal, C-H⋯O contacts generate infinite C (6) chains along the b -axis direction. Also present are π-π stacking inter-actions between neighbouring pyrone and benzene rings [centroid-centroid distance = 3.7034 (18) Å] and C=O⋯π inter-actions [O⋯centroid = 3...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765748/crystal-structure-of-2-8-aminona-phthalen-1-yl-imino-meth-yl-4-6-di-tert-butyl-phenolato-%C3%AE%C2%BA-3-n-n-o-bromido-nickel-ii
#11
Patrick O'Brien, Matthias Zeller, Wei-Tsung Lee
The title compound, [NiBr(C25 H29 N2 O)], contains an NiII atom with a slightly distorted square-planar coordination environment defined by one O and two N atoms from the 2-{[(8-aminona-phthalen-1-yl)imino]-meth-yl}-4,6-di- tert -butyl-phenolate ligand and a bromide anion. The Ni-O and Ni-N bond lengths are slightly longer than those observed in the phenyl backbone counterpart, which can be attributed to the larger steric hindrance of the naphthyl group in the structure of the title compound. The mol-ecule as a whole is substanti-ally distorted, with both the planar naphthalene-1,8-di-amine and imino-meth-yl-phenolate substitutents rotated against the NiN2 OBr plane by 38...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765730/synthesis-and-structure-of-an-aryl-tellurenium-ii-cation-4-tert-butyl-2-6-bis-1-pentyl-1-h-benz-imidazol-2-yl-%C3%AE%C2%BA-n-3-phenyl-%C3%AE%C2%BA-c-1-tellurium-ii-1-4-dioxane-tri-iodido-mercurate-ii
#12
Varsha Rani, Harkesh B Singh, Ray J Butcher
In the title salt, (C34 H41 N4 Te)[HgI3 (C4 H8 O2 )], the aryl-tellurenium [C34 H41 N4 Te]+ cations and [HgI3 (dioxane)]- anions are linked by a short inter-action between the Te atom and one of the I-atom donors of the anion, as well as through weak C-H⋯I inter-actions. The geometry around the Te atom is T-shaped with the coordination comprising a C atom of the central aromatic ring and two N atom donors of the benzimidazolyl moiety. The Te-N bond lengths are almost equal [2.232 (3) and 2.244 (3) Å], while the Te-C bond length is 2...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29763507/effect-of-titanium-surfaces-on-the-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#13
Diogo Godoy Zanicotti, Warwick John Duncan, Gregory John Seymour, Dawn Elizabeth Coates
PURPOSE: To investigate whether human adipose-derived stem cells will form a functional bone-like matrix on titanium substrates. The behavior of human adipose-derived stem cells was examined when grown in either serum-free, xeno-free stem cell growth medium or osteogenic differentiation medium and cultured on either machined titanium (MTi) or on roughened alumina-blasted titanium (ABTi) discs. MATERIALS AND METHODS: Cellular proliferation, extracellular mineralized matrix production, osteogenic-related protein production (RUNX2 and osteocalcin), and gene expression for pluripotency and self-renewal (TERT and OCT4) and osteogenic-related (MSX2, RUNX2, and BGLAP) genes were performed...
May 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29761872/electronic-interactions-in-illuminated-carbon-dots-mos2-ensembles-and-electrocatalytic-activity-towards-hydrogen-evolution
#14
Ruben Canton-Vitoria, Lorenzo Vallan, Esteban Urriolabeitia, Ana Benito, Wolfgang Maser, Nikos Tagmatarchis
We report on the preparation, characterization and photophysical and electrocatalytic properties of carbon dots (CDs)/MoS2 ensembles. Based on electrostatic interactions, ammonium functionalized MoS2, prepared upon reaction of 1,2-dithiolane tert-butyl carbamate with MoS2 followed by acidic deprotection, was coupled with CDs bearing multiple carboxylates on their periphery as derived upon microwave-assisted polycondensation of citric acid and ethylenediamine followed by alkaline treatment. Insights into electronic interactions between the two species within CDs/MoS2 emanated from absorption and photoluminescence titration assays...
May 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29760568/co-existence-of-braf-v600e-and-tert-promoter-mutations-in-papillary-thyroid-carcinoma-is-associated-with-tumor-aggressiveness-but-not-with-lymph-node-metastasis
#15
Haoyu Ren, Yifan Shen, Daixing Hu, Wei He, Jing Zhou, Yijia Cao, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Yuhong Zhang, Xinliang Su
Background: Mutations of BRAF V600E and TERT promoters are associated with thyroid cancer development. This study further investigated association of these mutations with clinicopathological characteristics from patients with papillary thyroid carcinoma (PTC). Methods: Tumor tissues from 342 PTC patients were obtained for DNA extraction and polymerase chain reaction amplification to detect the BRAF V600E mutation using amplification-refractory mutation system-polymerase chain reaction...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29759645/complementary-enantioselectivity-profiles-of-chiral-cinchonan-carbamate-selectors-with-distinct-carbamate-residues-and-their-implementation-in-enantioselective-two-dimensional-high-performance-liquid-chromatography-of-amino-acids
#16
Ulrich Woiwode, Martina Ferri, Norbert M Maier, Wolfgang Lindner, Michael Lämmerhofer
A cardinal requirement for effective 2D-HPLC separations is sufficient complementarity in the retention profiles of first and second dimension separations. It is shown that retention and enantioselectivity of chiral selectors derived from cinchona alkaloids can be conveniently modulated by structural variation of the carbamate residue of the quinine/quinidine carbamate ligand of such chiral stationary phases (CSP). A variety of aliphatic and aromatic residues have been tested in comparison to non-carbamoylated quinine CSP...
April 27, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29758186/supplementation-with-l-glutathione-improves-oxidative-status-and-reduces-protein-nitration-in-myenteric-neurons-in-the-jejunum-in-diabetic-rattus-norvegicus
#17
Catchia Hermes-Uliana, Flávia Cristina Vieira Frez, Camila Caviquioli Sehaber, Francielle Veiga Ramalho, Fernando Pinheiro de Souza Neto, Rubens Cecchini, Flávia Alessandra Guarnier, Jacqueline Nelisis Zanoni
Diabetes mellitus is a syndrome with multiple etiologies, characterized by chronic hyperglycemia that increases the production of reactive oxygen species and decreases antioxidant defenses. The present study evaluated oxidative stress parameters and protein nitration in myenteric neurons in the jejunum in diabetic rats supplemented with l-glutathione. Rats (90 days of age) were distributed into four groups (n = 6/group): normoglycemic (N), normoglycemic supplemented with l-glutathione (NGT), diabetic (D), and diabetic supplemented with l-glutathione (DGT)...
May 11, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29756140/synthesis-of-unsymmetrical-multi-aroyl-derivatives-of-ferrocene-using-palladium-catalysed-oxidative-c-h-aroylation
#18
Mayukh Deb, Susanta Hazra, Ajay Gupta, Anil J Elias
A palladium catalysed methodology for mono-selective oxidative aroylation of ferrocene has been achieved. 10 mol% of Pd(OAc)2 was used as the catalyst for this radical aroylation reaction using O-methyl-oxime as the directing group. tert-Butyl hydroperoxide was used as an oxidant and both aldehydes and alcohols were used as acyl-equivalents. The protocol has been extended to aryl, heteroaryl and sterically hindered aroylating agents. Acidic-hydrolysis with 6(N) HCl of the directing group resulted in unsymmetrically substituted ketone derivatives of ferrocene, which have not been achieved otherwise...
May 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29755769/an-assessment-of-candidate-genes-to-assist-prognosis-in-gastric-cancer
#19
Michael McFarlane, Julia Brettschneider, Adrian Gelsthorpe, Sean James, David Snead, Kishore Gopalakrishnan, Hisham Mehenna, Janusz Jankowski, Ramesh Arasaradnam, Chuka Nwokolo
Background: Gastric cancer (GC) is the fourth commonest cancer worldwide, with the second highest mortality rate. Its poor mortality is linked to delayed presentation. There is a drive towards non-invasive biomarker screening and monitoring of many different types of cancer, although with limited success so far. We aimed to determine if any genes from a 32-gene panel could be used to determine GC prognosis. Methods: We carried out a retrospective study on the expression of 32 genes, selected for their proven or potential links to GC, on historic formalin fixed paraffin-embedded (FFPE) GC specimens from our unit...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29754946/comparison-of-interfacial-behavior-and-silver-extraction-kinetics-with-various-types-calix-4-arene-derivatives-at-heterogeneous-liquid-liquid-interfaces
#20
Jee Young Kim, Shintaro Morisada, Hidetaka Kawakita, Keisuke Ohto
Various p-tert-octylcalix[4]arene derivatives as hydrophobic extractants have been prepared to investigate Ag(I) extraction efficiency in a batch-wise process in nitric acid media. The influence of the functional groups of the hydrophobic extractants on the interfacial behavior and Ag(I) extraction efficiency in nitric acid media has been investigated using the drop-volume method. Fitting of the interfacial tension isotherms to the Gibbs and Szyszkowski equations has provided parameters characterizing the interfacial activity of the extractants, in particular the Gibbs free energy of adsorption at the interface, the interface excess on saturation (Г∞ ) and the average area per the adsorbed extractant molecule (Amin )...
May 2, 2018: Journal of Chromatography. A
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