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Amy E Kalkbrenner, Gayle C Windham, Cheng Zheng, Rob McConnell, Nora L Lee, James J Schauer, Brian Thayer, Juhi Pandey, Heather E Volk
BACKGROUND: Previous studies have reported associations of perinatal exposure to air toxics, including some metals and volatile organic compounds, with autism spectrum disorder (ASD). OBJECTIVES: Our goal was to further explore associations of perinatal air toxics with ASD and associated quantitative traits in high-risk multiplex families. METHODS: We included participants of a U.S. family-based study [the Autism Genetic Resource Exchange (AGRE)] who were born between 1994 and 2007 and had address information...
March 12, 2018: Environmental Health Perspectives
Jana Tomc, Katja Kološa, Bojana Žegura, Urška Kamenšek, Barbara Breznik, Tamara Lah Turnšek, Metka Filipič
The problem of the currently used routine genotoxicity tests is relatively low predictivity of in vitro tests for in vivo genotoxicity and carcinogenicity. An important reason is considered to be inadequate expression of xenobiotic-metabolizing enzymes in indicator cell lines. The aim of our study was to generate metabolically active differentiated hepatic progenies (hDHP) from human adipose tissue-derived mesenchymal stem cells (hASC) for genotoxicity testing. hDHP, generated using a three-step hepatic differentiation procedure, expressed hepatic properties such as glycogen storage and albumin secretion...
March 16, 2018: Archives of Toxicology
Jianyong Zheng, Wei Wei, Xing Lan, Yinjun Zhang, Zhao Wang
This study describes a sensitive and fluorescent microplate assay method to detect lipase transesterification activity. Lipase-catalyzed transesterification between butyryl 4-methyl umbelliferone (Bu-4-Mu) and methanol in tert-butanol was selected as the model reaction. The release of 4-methylumbelliferone (4-Mu) in the reaction was determined by detecting the fluorescence intensity at λex 330 nm and λem 390 nm. Several lipases were used to investigate the accuracy and efficiency of the proposed method...
March 13, 2018: Analytical Biochemistry
Tetyana Kobets, Jian-Dong Duan, Klaus D Brunnemann, Michael J Iatropoulos, Sylvain Etter, Christina Hickey, Benjamin Smith, Gary M Williams
Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using32 P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-Gluc 'BlueScreen HC' genotoxicity assay, and standard in vitro and in vivo tests, were selected to evaluate the accuracy of TEGA. Quinoline (QUI) and 2-acetylaminofluorene (AAF) served as positive comparators. Two materials, p-tert-butyldihydrocinnamaldehyde (BDHCA) and methyl eugenol (MEU) produced DNA adducts...
March 13, 2018: Food and Chemical Toxicology
Matthieu Fumagalli, Julien Berriot, Benoit de Gaudemaris, Anne Veyland, Jean-Luc Putaux, Sonia Molina-Boisseau, Laurent Heux
Rubber materials with well-dispersed fillers and large mechanical reinforcement have been obtained by melt-processing a diene elastomer matrix and tailored nanocellulose powders having both a high specific surface area and a modified interface. Such filler powders with a specific surface area of 180 m2 g-1 and 100 m2 g-1 have been obtained by freeze-drying suspensions of short needle-like cellulose nanocrystals (CNCs) and entangled networks of microfibrillated cellulose (MFC) in tert-butanol/water, respectively...
March 16, 2018: Soft Matter
Jia-Yi Cai, Yuan-Yuan Wang, Kai Ma, Yong-Na Hou, Guo-Dong Yao, Toshihiko Hayashi, Kikuji Itoh, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Present study demonstrates that growth of Staphylococcus aureus in the presence of salicylate reduces ultraviolet C (UVC)-induced cell death and increases the generation of reactive oxygen species (ROS). In addition, compounds that scavenge ROS (N-acetylcysteine, glutathione, catalase and superoxide dismutase) reverse the increased UVC survival induced by growth in the presence of salicylate, while ROS donors (tert-butylhydroperoxide, H2O2, and NaClO) enhance survival of salicylate challenged cultures. Collectively these findings suggest that ROS production induced by growth in the presence of salicylate protects S...
March 13, 2018: FEMS Microbiology Letters
Berc Kalanyan, William A Kimes, Ryan Beams, Stephan J Stranick, Elias Garratt, Irina Kalish, Albert V Davydov, Ravindra K Kanjolia, James E Maslar
High volume manufacturing of devices based on transition metal dichalcogenide (TMD) ultra-thin films will require deposition techniques that are capable of reproducible wafer-scale growth with monolayer control. To date, TMD growth efforts have largely relied upon sublimation and transport of solid precursors with minimal control over vapor phase flux and gas-phase chemistry, which are critical for scaling up laboratory processes to manufacturing settings. To address these issues, we report a new pulsed metalorganic chemical vapor deposition (MOCVD) route for MoS2 film growth in a research-grade single-wafer reactor...
August 8, 2017: Chemistry of Materials: a Publication of the American Chemical Society
Joydeep Mukherjee, Tor-Christian Aase Johannessen, Shigeo Ohba, Tracy T Chow, Lindsey E Jones, Ajay Pandita, Russell O Pieper
A subset of tumors use a recombination-based alternative lengthening of telomere (ALT) pathway to resolve telomeric dysfunction in the absence of TERT. Loss-of-function mutations in the chromatin remodeling factor ATRX are associated with ALT but are insufficient to drive the process. Because many ALT tumors express the mutant isocitrate dehydrogenase IDH1 R132H, including all lower-grade astrocytomas (LGA) and secondary glioblastoma, we examined an hypothesized role for IDH1 R132H in driving the ALT phenotype during gliomagenesis...
March 15, 2018: Cancer Research
Jan Paulo T Zaragoza, Maxime A Siegler, David P Goldberg
High-valent metal-hydroxide species are invoked as critical intermediates in both catalytic, metal-mediated O2 activation (e.g., by Fe porphyrin in Cytochrome P450) and O2 production (e.g., by the Mn cluster in Photosystem II). However, well-characterized mononuclear MIV (OH) complexes remain a rarity. Herein we describe the synthesis of MnIV (OH)(ttppc) (3) (ttppc = tris(2,4,6-triphenylphenyl) corrole), which has been characterized by X-ray diffraction (XRD). The large steric encumbrance of the ttppc ligand allowed for isolation of 3...
March 15, 2018: Journal of the American Chemical Society
Nicholas R Andreychuk, Tara Dickie, David J H Emslie, Hilary A Jenkins
Palladium-catalyzed coupling of 1-adamantylamine (2 equiv.) with 4,5-dibromo-2,7-di-tert-butyl-9,9-dimethylxanthene afforded the proligand 4,5-bis(1-adamantylamino)-2,7-di-tert-butyl-9,9-dimethylxanthene, H2 [XAd] (1), which upon deprotonation with excess KH or KCH2 Ph in THF or dme generated [{K(THF)3 }2 (XAd)] (2a) and [K2 (XAd)(dme)] (2b). Subsequent reaction of in situ generated 2a or 2b with [ThCl4 (dme)2 ] yielded [(XAd)ThCl4 K2 ]·x(dme) (3; x = 0.5-2), which reacted with 2 equiv. of LiCH2 SiMe3 or K[allylTMS ] to afford the bis(hydrocarbyl) complexes [(XAd)Th(CH2 SiMe3 )2 (THF)] (4) and [(XAd)Th(η3 -allylTMS )2 ] {5; allylTMS = 1-(SiMe3 )C3 H4 }...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Claus Hierlinger, David B Cordes, Alexandra M Z Slawin, Denis Jacquemin, Véronique Guerchais, Eli Zysman-Colman
This study concerns an assessment of the impact of the interruption of the electronic crosstalk between the pyridine rings in the ancillary ligand on the photoluminescence properties of the corresponding iridium(iii) complexes. Two new cationic Ir(iii) complexes, [Ir(dFmesppy)2 (pmdp)]PF6 , 1, and [Ir(mesppy)2 (pmdp)]PF6 , 2, [where dFmesppy is 2-(2,4-difluorophenyl)-4-mesitylpyridinato, mesppy is 4-mesityl-2-phenylpyridinato and pmdp is 2,2'-(phenylmethine)dipyridine, L1] possessing sterically congested cyclometalating ligands combined with the nonconjugated diimine ancillary N^N ligand are reported and their solution-state and thin film photophysical properties analyzed by both experimental and theoretical methods...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Irene Gullo, Rui Batista, Pedro Rodrigues-Pereira, Paula Soares, Helena Barroca, Maria do Bom-Sucesso, Manuel Sobrinho-Simões
Objectives: Multinodular goiter (MNG) and well-differentiated thyroid carcinoma (WDTC) are emerging phenotypes of DICER1 syndrome. Methods: Histologic and molecular findings of botryoid-type embryonal rhabdomyosarcoma (bERMS) and thyroid nodules from a 12-year-old DICER1 mutation carrier (p.Arg1060Ilefs*7) were investigated, providing interesting clues for understanding thyroid carcinogenesis. Results: The patient had bERMS at age 7 years...
March 10, 2018: American Journal of Clinical Pathology
Reinier Snetselaar, Matthijs F M van Oosterhout, Jan C Grutters, Coline H M van Moorsel
The enzyme telomerase reverse transcriptase (TERT) is essential for telomere maintenance. In replicating cells, maintenance of telomere length is important for the preservation of vital genetic information and prevention of genomic instability. A common genetic variant in TERT , rs2736100 C/A, is associated with both telomere length and multiple diseases. Carriage of the C allele is associated with longer telomere length, while carriage of the A allele is associated with shorter telomere length. Furthermore, some diseases have a positive association with the C and some with the A allele...
2018: Frontiers in Medicine
Xiangyu Wang, Donghai Xia, Hai Han, Kun Peng, Peijie Zhu, Jacques Crommen, Qiqin Wang, Zhengjin Jiang
The rapid development of monoclonal antibodies (mAbs) in therapeutic and diagnostic applications has necessitated the advancement of mAbs purification technologies. In this study, a biomimetic small peptide ligand 3,5-di-tert-butyl-4-hydroxybenzoic acid-Arg-Arg-Gly (DAAG) functionalized monolith was fabricated through a metal ion chelation-based multi-step approach. The resulting monolith showed good chromatographic performance. Compared with the Ni2+ based IMAC monolith, the DAAG functionalized monolith exhibited not only excellent specificity but also higher dynamic binding capacity (DBC)...
August 9, 2018: Analytica Chimica Acta
Zhengsheng Liu, Tao Wang, Zhun Wu, Kaiyan Zhang, Wei Li, Jianbin Yang, Chenxi Chen, Lei Chen, Jinchun Xing
BACKGROUND: It has been reported that the functional telomerase reverse transcriptase (TERT) rs2853669 polymorphism might contribute to different types of human cancer. However, the association of this mutation with cancer remains controversial. Here, we conducted a meta-analysis to characterize this relationship. MATERIALS AND METHODS/MAIN RESULTS: A systematic search of studies on the association of TERT rs2853669 polymorphism with all types of cancer was conducted in PubMed, Embase and Cochrane Library...
2018: PloS One
Takaaki Yamamoto, Koki Mitsuno, Shigeki Mori, Shuhei Itoyama, Yoshihito Shiota, Kazunari Yoshizawa, Masatoshi Ishida, Hiroyuki Furuta
Complexation of a RuCp* cation with N-confused tetraarylporphyrins (NCPs) forms directly bound ruthenium(II) pentamethylcyclopentadienyl (Cp*) π-complex on a specific meso-aryl group (e.g., phenyl) neighbouring peripheral imino nitrogen of NCPs in high yields. In contrast, in the case of NCPs bearing bulky meso-substituents (e.g., 3,5-di-tert-butylphenyl), novel ruthenocenophane-like complex embedded on an N-confused calix[4]phyrin was formed through multiple C-H bond activation of methyl groups of Cp* ligand...
March 13, 2018: Chemistry: a European Journal
Takuya Furuta, Hiroaki Miyoshi, Satoru Komaki, Fumiko Arakawa, Motohiro Morioka, Koichi Ohshima, Mitsutoshi Nakada, Yasuo Sugita
Epithelioid glioblastoma (eGBM) is a rare variant of GBM which was adopted in the 2016 WHO classification. eGBM and pleomorphic xanthoastrocytoma (PXA) sometimes show overlapping features histologically and genetically, such as epithelioid pattern and a highly frequent V600E mutation in the gene for vRAF murine sarcoma viral oncogene homolog B1 (BRAF), respectively. Accurate diagnosis of these rare tumors is challenging according to the new criteria in the revised 2016 WHO classification. It is an urgent task to elucidate the biological properties of the tumors and to select appropriate treatment...
March 13, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Juan Zhang, Lorelei Donovan Tucker, DongYan, Yujiao Lu, Luodan Yang, Chongyun Wu, Yong Li, Quanguang Zhang
Hypoxic-ischemic (HI) encephalopathy is a leading cause of dire mortality and morbidity in neonates. Unfortunately, no effective therapies have been developed as of yet. Oxidative stress plays a critical role in pathogenesis and progression of neonatal HI. Previously, as a Nrf2 activator, tert-butylhydroquinone (TBHQ) has been demonstrated to exert neuroprotection on brain trauma and ischemic stroke models, as well as oxidative stress-induced cytotoxicity in neurons. It is, however, still unknown whether TBHQ administration can protect against oxidative stress in neonatal HI brain injury...
March 9, 2018: Neurochemistry International
Regina G Belz, Marjo Patama, Aki Sinkkonen
Toxicants are known to have negligible or stimulatory, i.e. hormetic, effects at low doses below those that decrease the mean response of a plant population. Our earlier observations indicated that at such low toxicant doses the growth of very fast- and slow-growing seedlings is selectively altered, even if the population mean remains constant. Currently, it is not known how common these selective low-dose effects are, whether they are similar among fast- and slow-growing seedlings, and whether they occur concurrently with hormetic effects...
March 9, 2018: Science of the Total Environment
Sudipta Mondal, Brigitte Schwederski, Wolfgang Frey, Jan Fiedler, Stanislav Záliš, Wolfgang Kaim
The complex ions [L3 Ru(μ,η3 :η3 -BL)RuL3 ]n+ (1n+ , L3 = 4,4',4″-tri- tert-butyl-2,6,2',6″-terpyridine and H2 BL2- = 1,2-bis(salicyloyl)hydrazide(2-)) were isolated with PF6 - or ClO4 - counterions ( n = 1) and as bis(hexafluorophosphate) ( n = 2). Structural, electrochemical, and spectroscopic characterization reveals the monocation as intermediate ( Kc = 108.2 ) in the three-step reversible redox system 10/+/2+/3+ . The 1+ ion has the molecule-bridged (Ru- - -Ru 4.727 Å) ruthenium centers involved in five- and six-membered chelate rings, and it exhibits long-wavelength absorptions at λmax 2240, 1660, and 1530 nm (εmax = 1000, 3000, and 8000 M-1 cm-1 , respectively), which would be compatible with a RuIII RuII mixed-valent situation or with a coordinated radical ion bridge...
March 12, 2018: Inorganic Chemistry
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