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https://www.readbyqxmd.com/read/28212542/two-stage-genome-wide-association-study-identifies-a-novel-susceptibility-locus-associated-with-melanoma
#1
Katherine J Ransohoff, Wenting Wu, Hyunje G Cho, Harvind C Chahal, Yuan Lin, Hong-Ji Dai, Christopher I Amos, Jeffrey E Lee, Jean Y Tang, David A Hinds, Jiali Han, Qingyi Wei, Kavita Y Sarin
Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-stage genome-wide association study of melanoma. The stage 1 discovery phase consisted of 4,842 self-reported melanoma cases and 286,565 controls of European ancestry from the 23andMe research cohort and the stage 2 replication phase consisted of 1,804 melanoma cases and 1,026 controls from the University of Texas M...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212397/a-targeted-gene-expression-platform-allows-for-rapid-analysis-of-chemical-induced-antioxidant-mrna-expression-in-zebrafish-larvae
#2
Margaret G Mills, Evan P Gallagher
Chemical-induced oxidative stress and the biochemical pathways that protect against oxidative damage are of particular interest in the field of toxicology. To rapidly identify oxidative stress-responsive gene expression changes in zebrafish, we developed a targeted panel of antioxidant genes using the Affymetrix QuantiGene Plex (QGP) platform. The genes contained in our panel include eight putative Nrf2 (Nfe2l2a)-dependent antioxidant genes (hmox1a, gstp1, gclc, nqo1, prdx1, gpx1a, sod1, sod2), a stress response gene (hsp70), an inducible DNA damage repair gene (gadd45bb), and three reference genes (actb1, gapdh, hprt1)...
2017: PloS One
https://www.readbyqxmd.com/read/28212027/ferromagnetic-coupling-in-the-heterospin-bis-catecholato-manganese-iv-complex-with-pyridine-substituted-by-nitronyl-nitroxide
#3
Michael P Bubnov, Irina A Teplova, Eugenia A Kopylova, Konstantin A Kozhanov, Artem S Bogomyakov, Marina V Petrova, Vitaly A Morozov, Victor I Ovcharenko, Vladimir K Cherkasov
A new bis(3,6-di-tert-butyl-catecholato)manganese complex with two 4-NIT-Py ligands was synthesized and characterized [4-NIT-Py = pyridine substituted at position 4 with nitronyl-nitroxide radical, 2-(pyridin-4-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl]. X-ray diffraction indicated an octahedral environment of the manganese atom with a trans arrangement of ligands. Bonds lengths in the inner coordination core of the metal and in the chelate cycles that are representative of the charge distribution between the metal and ligands displayed a Mn(IV)(Cat(2-))2 charge distribution...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211691/lipophilized-grape-seed-proanthocyanidin-derivatives-as-novel-antioxidants
#4
Mingshun Chen, Shujuan Yu
Grape seed proanthocyanidin (GSP) is a natural food antioxidant. Natural proanthocyanidins (PC) in grape seed are usually polyhydroxy derivatives which exhibit hydrophilic character. GSP was modified structurally to improve its lipophilicity, expand its application in lipophilic media, and enhance its cellular absorption in vivo. Esterification of the water-soluble GSP was prepared by immobilized lipase Lipozyme TL IM with lauric acid, and their enhanced lipophilicity was confirmed by the 1-octanol/water partition coefficient...
February 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28211228/palladium-catalyzed-direct-stereoselective-synthesis-of-deoxyglycosides-from-glycals
#5
Abhijit Sau, Ryan Williams, Carlos Palo-Nieto, Antonio Franconetti, Sandra Medina, M Carmen Galan
Palladium(II) in combination with a monodentate phosphine ligand enables the unprecedented direct and α-stereoselective catalytic synthesis of deoxyglycosides from glycals. Initial mechanistic studies suggest that in the presence of N-phenyl-2-(di-tert-butylphosphino)pyrrole as the ligand, the reaction proceeds via an alkoxy palladium intermediate that increases the proton acidity and oxygen nucleophilicity of the alcohol. The method is demonstrated with a wide range of glycal donors and acceptors, including substrates bearing alkene functionalities...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28210881/comprehensive-genomic-profiling-of-malignant-phyllodes-tumors-of-the-breast
#6
Sahar Nozad, Christine E Sheehan, Laurie M Gay, Julia A Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Alexa B Schrock, Kim M Hirshfield, Nadia Ali, Shridar Ganesan, Siraj M Ali, Vincent A Miller, Philip J Stephens, Jeffrey S Ross, Jon H Chung
PURPOSE: Malignant phyllodes tumors (MPT) are exceptionally rare, and the genomic drivers of these tumors are still being elucidated. We performed comprehensive genomic profiling (CGP) of MPT to identify genomic alterations that will inform approaches to targeted therapy for patients with MPT, including relapsed, refractory, and metastatic disease. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded samples from 24 consecutive patient cases of MPT...
February 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28210727/mn-iv-and-mn-v-radical-species-supported-by-the-redox-non-innocent-bis-2-amino-3-5-di-tert-butylphenyl-amine-pincer-ligand
#7
Nicolas Leconte, Jules Moutet, Khrystyna Herasymchuk, Ryan M Clarke, Christian Philouze, Dominique Luneau, Tim Storr, Fabrice Thomas
The electron-rich pincer ligand 1 has been synthesized and chelated to manganese. The octahedral Mn(iv) bis(diiminosemiquinonate) and Mn(v) (diiminobenzoquinone) (diiminosemiquinonate) radicals were structurally characterized.
February 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28208108/dietary-administration-of-edc-mixtures-a-focus-on-fish-lipid-metabolism
#8
O Carnevali, V Notarstefano, I Olivotto, M Graziano, P Gallo, I Di Marco Pisciottano, L Vaccari, A Mandich, E Giorgini, F Maradonna
Many man-made chemical compounds are recognized as endocrine disruptors and once released into the environment are likely to spread and bioaccumulate in wild species. Due to their lipophilic nature, these substances pass through the cell membrane or bind to specific receptors activating physiological responses that in the long run can cause reproductive impairment, physiological disorders, including the occurrence of metabolic syndromes. One significant source of contamination is represented by the consumption of polluted food...
February 6, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28208013/sex-differences-in-autism-like-behavioral-phenotypes-and-postsynaptic-receptors-expression-in-the-prefrontal-cortex-of-tert-transgenic-mice
#9
Ki Chan Kim, Kyu Suk Cho, Sung Min Yang, Edson Luck Gonzales, Schley Valencia, Pyeong Hwa Eun, Chang Soon Choi, Darine Froy Mabunga, Ji-Woon Kim, Judy Kyoungju Noh, Hee Jin Kim, Se Jin Jeon, Seol-Heui Han, Geon Ho Bahn, Chan Young Shin
Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28205272/homometallic-dyiii-complexes-of-varying-nuclearity-from-2-to-21-synthesis-structure-and-magnetism
#10
Vadapalli Chandrasekhar, Sourav Biswas, Sourav Das, Joydev Acharya, Vierandra Kumar, Jan Leusen, Juan Manuel Herrera, Paul Koegerler, Enrique Colacio
The synthesis, structure and magnetic properties of the four Dy(III) coordination compounds isolated as [Dy2(LH2)2(μ2-η1:η1-Piv)]Cl·2MeOH·H2O (1), [Dy4(LH)2(μ3-OH)2(Piv)4(MeOH)2]·4MeOH·2H2O(2), [Dy6(LH2)3(tfa)3(O3PtBu)(Cl)3]Cl4·15.5H2O·4MeOH· 5CHCl3 (3) and [Dy21(L)7(LH)7(tfa)7]Cl7·15H2O·7MeOH·12CHCl3 (4) are reported (Piv = pivalate, tfa = 1,1,1-trifluoro-acetylacetone, O3PtBu = tert-butylphosphonate). Some of these polynuclear coordination complexes exhibit aesthetic and unprecedented structural features...
February 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28205265/borylative-radical-cyclizations-of-benzo-3-4-cyclodec-3-ene-1-5-diynes-and-n-heterocyclic-carbene-boranes
#11
Takashi Watanabe, Daisuke Hirose, Dennis P Curran, Tsuyoshi Taniguchi
Borylative radical cyclization of benzo[3,4]cyclodec-3-ene-1,5-diynes to provide 5-borylated 6,7,8,9-tetrahydrobenzo[a]azulenes has been developed. The experimental results suggest that the reaction proceeds by a radical chain mechanism, and di-tert-butyl hyponitrite (TBHN) works as a good radical initiator to form boryl radicals from N-heterocyclic carbene-boranes (NHC-boranes). The present reaction is a rare model to illustrate addition of boryl radicals to alkynes.
February 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28202125/-effect-of-telomerase-activation-on-biological-behaviors-of-neural-stem-cells-in-rats-with-hypoxic-ischemic-insults
#12
Jun-Jie Meng, Shi-Ping Li, Feng-Yan Zhao, Yu Tong, De-Zhi Mu, Yi Qu
OBJECTIVE: To investigate the effect of telomerase activation on biological behaviors of neural stem cells after hypoxic-ischemic insults. METHODS: The neural stem cells passaged in vitro were divided into four groups: control, oxygen-glucose deprivation (OGD), OGD+cycloastragenol (CAG) high concentration (final concentration of 25 μM), and OGD+CAG low concentration (final concentration of 10 μM). The latter three groups were subjected to OGD. Telomerase reverse transcriptase (TERT) expression level was evaluated by Western blot...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28199114/curcumin-loaded-blood-stable-polymeric-micelles-for-enhancing-therapeutic-effect-on-erythroleukemia
#13
Feirong Gong, Dan Chen, Xin Teng, Junhua Ge, Xianfeng Ning, Ya-Ling Shen, Jian Li, Shanfeng Wang
Curcumin has high potential in suppressing many types of cancer and overcoming multi-drug resistance in a multi-faceted manner by targeting diverse molecular targets. However, the rather low systemic bioavailability resulted from its extremely low aqueous solubility and rapid metabolism and excretion in vivo has hampered its application in cancer therapy. With the primary aim to increase the aqueous solubility of curcumin while retaining its stability in the blood circulation before it accesses the tumor site, here we report preparation of curcumin-loaded N-(tert-butoxycarbonyl)-L-phenylalanine end-capped methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL-Phe(Boc)) micelles with high stability both in vitro and in vivo and anti-tumor efficacy...
February 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28198623/dangling-and-hydrolyzed-ligand-arms-in-mn3-and-mn6-coordination-assemblies-synthesis-characterization-and-functional-activity
#14
Krishna Chattopadhyay, Gavin A Craig, María José Heras Ojea, Moumita Pait, Animesh Kundu, Junseong Lee, Mark Murrie, Antonio Frontera, Debashis Ray
Two flexible, branched, and sterically constrained di- and tripodal side arms around a phenol backbone were utilized in ligands H3L1 and H5L2 to isolate {Mn6} and {Mn3} coordination aggregates. 2,6-Bis{(1-hydroxy-2-methylpropan-2-ylimino)methyl}-4-methylphenol (H3L1) gave trinuclear complex [Mn3(μ-H2L1)2(μ1,3-O2CCH3)4(CH3OH)2](ClO4)2·4CH3OH (1), whereas 2,6-bis[{1-hydroxy-2-(hydroxymethyl)butan-2-ylimino}methyl]-4-methylphenol (H5L2) provided hexanuclear complex [Mn6(μ4-H2L2)2(μ-HL3)2(μ3-OH)2(μ1,3-O2CC2H5)4](ClO4)2·2H2O (2)...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28198594/interfacial-engineering-of-perovskite-solar-cells-by-employing-a-hydrophobic-copper-phthalocyanine-derivative-as-hole-transporting-material-with-improved-performance-and-stability
#15
Ze Yu, Xiaoqing Jiang, Jianbo Lai, Yuchen Zhang, Maowei Hu, Ning Lei, Dongping Wang, Xichuan Yang, Licheng Sun
In high-performance perovskite solar cells (PSCs), hole-transporting materials (HTMs) play important roles in extracting and transporting the photo-generated holes from the perovskite absrorber to the cathode, thus reducing unwanted recombination losses and enhancing the photovoltaic performance. Herein, solution-processable tetra-4-(bis(4-tert-butyl)phenyl)amino)phenoxy-substituted copper phthalocyanine (CuPc-OTPAtBu) has been synthesized and explored as a HTM in PSCs. The optical, electrochemical and thermal properties are fully characterized for this organic metal complex...
February 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28198186/esterification-of-the-primary-benzylic-c-h-bonds-with-carboxylic-acids-catalyzed-by-ionic-iron-iii-complexes-containing-an-imidazolinium-cation
#16
Bing Lu, Fan Zhu, Hong-Mei Sun, Qi Shen
The first iron-catalyzed esterification of the primary benzylic C-H bonds with carboxylic acids using di-tert-butyl peroxide as an oxidant is achieved by novel ionic iron(III) complexes containing an imidazolinium cation. The use of well-defined, air-stable, and available iron(III) complex in a 5 mol % loading and readily available starting materials with a broad generality and outstanding sterically hindered tolerance renders this methodology a useful alternative to other protocols that are typically employed for the synthesis of benzyl esters...
February 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28197595/selective-palladium-ii-mediated-oxidation-of-homoallylic-n-tert-butanesulfinyl-amine-derivatives
#17
Ana Sirvent, Tatiana Soler, Francisco Foubelo, Miguel Yus
The palladium(ii)-catalyzed oxidation of homoallylic amine derivatives resulting from the allylation of N-tert-butanesulfinyl imines with allyl bromide led to the formation of the corresponding terminal allylic acetates in a regioselective fashion in moderate yields. In the case of the homoallylic amine derivatives obtained using cyclohexenyl bromide as the allylating reagent, the allylic oxidation took place with high regio- and diastereoselectivity and yields ranging from 40 to 85%.
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28195740/the-conversion-of-tert-butyl-esters-to-acid-chlorides-using-thionyl-chloride
#18
Jacob Arthur Greenberg, Tarek Sammakia
The reaction of tert-butyl esters with SOCl2 at room temperature provides acid chlorides in unpurified yields of 89% or greater. Benzyl, methyl, ethyl, and isopropyl esters are essentially unreactive under these conditions, allowing for the selective conversion of tert-butyl esters to acid chlorides in the presence of other esters.
February 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28195281/highly-branched-photomechanical-crystals
#19
Rabih O Al-Kaysi, Fei Tong, Maram Al-Haidar, Lingyan Zhu, Christopher J Bardeen
When a suspension of the tert-butyl ester of 4-fluoroanthracene-9-carboxylic acid (4F9AC) was slowly hydrolyzed, highly branched photomechanical microcrystals of 4F9AC were grown. Exposure to UV light caused the branches to undergo a reversible sweeping motion that could be used to move and concentrate silica microspheres on a surface.
February 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28195142/a-genome-wide-association-study-yields-five-novel-thyroid-cancer-risk-loci
#20
Julius Gudmundsson, Gudmar Thorleifsson, Jon K Sigurdsson, Lilja Stefansdottir, Jon G Jonasson, Sigurjon A Gudjonsson, Daniel F Gudbjartsson, Gisli Masson, Hrefna Johannsdottir, Gisli H Halldorsson, Simon N Stacey, Hannes Helgason, Patrick Sulem, Leigha Senter, Huiling He, Sandya Liyanarachchi, Matthew D Ringel, Esperanza Aguillo, Angeles Panadero, Enrique Prats, Almudena Garcia-Castaño, Ana De Juan, Fernando Rivera, Li Xu, Lambertus A Kiemeney, Gudmundur I Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Hoskuldur Kristvinsson, Romana T Netea-Maier, Thorvaldur Jonsson, Jose I Mayordomo, Theo S Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M Sturgis, Unnur Thorsteinsdottir, Thorunn Rafnar, Albert de la Chapelle, Kari Stefansson
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22...
February 14, 2017: Nature Communications
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