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https://www.readbyqxmd.com/read/27913239/strategy-for-assessment-of-the-colloidal-and-biological-stability-of-h1n1-influenza-a-viruses
#1
Frank Hämmerling, Oliver Lorenz-Cristea, Pascal Baumann, Jürgen Hubbuch
Current influenza vaccines are mostly formulated as liquids which requires a continuous cold chain to maintain the stability of the antigen. For development of vaccines with an increased stability at ambient temperatures, manifold parameters and their influences on the colloidal stability and activity of the antigen have to be understood. This work presents a strategy to examine both, the colloidal stability and the remaining biological activity of H1N1 influenza viruses under various conditions after an incubation of 40 days...
November 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27912069/immunogenicity-and-safety-of-southern-hemisphere-quadrivalent-inactivated-influenza-vaccine-a-phase-iii-open-label-study-of-adults-in-brazil
#2
Cristiano A F Zerbini, Rodrigo Ribeiro Dos Santos, Maria Jose Nunes, Jyoti Soni, Ping Li, Varsha K Jain, Opokua Ofori-Anyinam
The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines...
November 29, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27910867/effects-of-annual-influenza-vaccination-on-morbidity-and-mortality-in-patients-with-systemic-lupus-erythematosus-a-nationwide-cohort-study
#3
Chi-Ching Chang, Yu-Sheng Chang, Wei-Sheng Chen, Yi-Hsuan Chen, Jin-Hua Chen
Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan's insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910810/production-of-tnf-alpha-ex-vivo-is-predictive-of-an-immune-response-to-flu-vaccination-in-a-frail-elderly-population
#4
Frédéric Bloch, Bénédicte Charmeteau, Michael Tovey, Jean-François Meritet, Corinne Desaint, Odile Launay, Pierre Lebon
OBJECTIVE: To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects. METHODS: Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate the secretion of five specific cytokines: TNFα, IFNα, IFNγ, IL2 and IL10. The results were correlated with the increased HAI antibody titres two weeks after vaccination...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27910264/vaccination-against-h9n2-avian-influenza-virus-reduces-bronchus-associated-lymphoid-tissue-formation-in-cynomolgus-macaques-after-intranasal-virus-challenge-infection
#5
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara
H9N2 avian influenza virus causes sporadic human infection. Since humans do not possess acquired immunity specific to this virus, we examined the pathogenicity of an H9N2 virus isolated from a human and then analyzed protective effects of a vaccine in cynomolgus macaques. After intranasal challenge with A/Hong Kong/1073/1999 (H9N2) (HK1073) isolated from a human patient, viruses were isolated from nasal and tracheal swabs in unvaccinated macaques with mild fever and body weight loss. A formalin-inactivated H9N2 whole particle vaccine derived from our virus library was subcutaneously inoculated to macaques...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27908830/protective-efficacy-of-fc-targeting-conserved-influenza-virus-m2e-antigen-expressed-by-lactobacillus-plantarum
#6
Wen-Tao Yang, Gui-Lian Yang, Qian Wang, Hai-Bin Huang, Yan-Long Jiang, Chun-Wei Shi, Jian-Zhong Wang, Ke-Yan Huang, Yu-Bei Jin, Chun-Feng Wang
The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transferring IgG across polarized epithelial cells. In the present study, an oral vaccine was developed using Lactobacillus plantarum to deliver the internal influenza viral protein M2e fused to an IgG Fc fragment...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27906921/rheumatologists-fail-to-advise-people-with-ra-to-get-immunised-which-matters-if-you-are-under-65-an-audit-in-a-new-zealand-rheumatology-service
#7
Brendan Ng, Lynn McBain, Rebecca Grainger
AIM: To assess if yearly-influenza and five-yearly pneumococcal vaccines are recommended to people with rheumatoid arthritis (RA) in a New Zealand rheumatology service in accordance with guidelines and determine patient immunisation status for these respiratory pathogens. METHODS: Retrospective review of electronic health records of all outpatients with RA attending a regional rheumatology centre in New Zealand over a one-month period immediately after the release of the 2015 influenza vaccination...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27906903/announcement-national-influenza-vaccination-week-december-4-10-2016
#8
(no author information available yet)
The U.S. Department of Health and Human Services, CDC, state and local health departments, and other partners will observe National Influenza Vaccination Week during December 4-10, 2016, with educational and promotional activities across the country. Beginning in 2005, National Influenza Vaccination Week was established to highlight the importance of annual influenza vaccination and to foster greater use of influenza vaccine during the months of December, January, and beyond. Last season, almost half (45.6%) of the U...
December 2, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27905835/hemagglutination-inhibiting-antibody-persistence-1-year-after-of-influenza-vaccination-in-korean-children-and-adolescents
#9
Eun-Kyeong Kang, Byung-Wook Eun, Nam-Hee Kim, Yun-Kyung Kim, Jung-Sub Lim, Dong-Ho Kim
This study aimed to assess the one-year immunogenicity of influenza vaccines and the association between immunogenicity at one month and further influenza infections in children aged 6 months to 18 years. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 months post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27903558/cost-effectiveness-analysis-of-routine-pneumococcal-vaccination-in-the-uk-a-comparison-of-the-phid-cv-vaccine-and-the-pcv-13-vaccine-using-a-markov-model
#10
Emmanuelle Delgleize, Oscar Leeuwenkamp, Eleni Theodorou, Nicolas Van de Velde
OBJECTIVES: In 2010, the 13-valent pneumococcal conjugate vaccine (PCV-13) replaced the 7-valent vaccine (introduced in 2006) for vaccination against invasive pneumococcal diseases (IPDs), pneumonia and acute otitis media (AOM) in the UK. Using recent evidence on the impact of PCVs and epidemiological changes in the UK, we performed a cost-effectiveness analysis (CEA) to compare the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with PCV-13 in the ongoing national vaccination programme...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27902910/recombinant-hemagglutinin-of-avian-influenza-virus-h5-expressed-in-the-chloroplast-of-chlamydomonas-reinhardtii-and-evaluation-of-its-immunogenicity-in-chickens
#11
Inkar Castellanos-Huerta, Bernardo Bañuelos-Hernández, Guillermo Téllez, Sergio Rosales-Mendoza, Luis G Brieba, Elizabeth Esquivel-Ramos, Josué I Beltrán-López, Gilberto Velazquez, Isidro Fernandez-Siurob
Globally, avian influenza (AI) is a serious problem in poultry farming. Despite vaccination, the prevalence of AI in México highlights the need for new approaches to control AI and to reduce the economic losses associated with its occurrence in susceptible birds. Recombinant proteins from avian influenza virus (AIV) have been expressed in different organisms, such as plants. The present study investigated the feasibility of designing and expressing the HA protein of AIV in the transplastomic microalga Chlamydomonas reinhardtii as a novel approach for AIV control and taking advantage of culture conditions, its reproductive range, and safe use in consideration of the generally regarded as safe food ingredient regulatory classification...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902899/endemic-variation-of-h9n2-avian-influenza-virus-in-china
#12
Yu-Fu Liu, Han-Zhang Lai, Lin Li, Yu-Peng Liu, Wen-Yan Zhang, Ren Gao, Wen-Ke Huang, Qin-Fang Luo, Yan Gao, Qiong Luo, Xiao-Yu Xie, Jia-Hua Xu, Rui-Ai Chen
Forty-two H9N2 subtype AIV strains were isolated from vaccinated commercial chickens in China from 2012 to 2015. Their HA genes had nucleotide sequence homology from 86.7% to 99.7%, and similarity to the classic vaccine strain was 88.6%-92.6%. A comparison was carried out with published HA genes (410 H9 strains) and whole genomes (306 strains) isolated in China during 2012-2015. Interestingly, 99.1% (448/452) of Chinese H9N2 AIV belonged to lineage h9.4.2, and 98.5% (445/452) of the viruses belonged to h9.4...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902762/presenting-influenza-a-m2e-antigen-on-recombinant-spores-of-bacillus-subtilis
#13
Tomasz Łęga, Paulina Weiher, Michał Obuchowski, Dawid Nidzworski
Effective vaccination against influenza virus infection is a serious problem mainly due to antigenic variability of the virus. Among many of investigated antigens, the extracellular domain of the M2 protein (M2e) features high homology in all strains of influenza A viruses and antibodies against M2e and is protective in animal models; this makes it a potential candidate for generation of a universal influenza vaccine. However, due to the low immunogenicity of the M2e, formulation of a vaccine based on this antigen requires some modification to induce effective immune responses...
2016: PloS One
https://www.readbyqxmd.com/read/27902651/influenza-vaccine-effectiveness-in-preventing-influenza-illness-among-children-during-school-based-outbreaks-in-the-2014-2015-season-in-beijing-china
#14
Li Zhang, Peng Yang, Mark G Thompson, Yang Pan, Chunna Ma, Shuangsheng Wu, Ying Sun, Man Zhang, Wei Duan, Quanyi Wang
BACKGROUND: Little is known about VE against non-medically attended A(H3N2) influenza illness during 2014-2015 when the vaccine component appeared to be a poor match with circulating strains. METHODS: Forty-three eligible school influenza outbreaks in Beijing, China from November 1 to December 31, 2014 were included in this study. The VE of 2014-2015 trivalent inactivated influenza vaccine (IIV3) was assessed in preventing laboratory-confirmed influenza among school-age children through a case-control design, using asymptomatic controls...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27902386/establishment-of-memory-cd8-t-cells-with-live-attenuated-influenza-virus-laiv-across-different-vaccination-doses
#15
Zhongfang Wang, Lukasz Kedzierska, Simone Nuessing, Brendon Chua, Sergio M Quiñones-Parra, Victor C Huber, David Jackson, Paul G Thomas, Katherine Kedzierska
FluMist has been used in children and adults for more than ten years. As pre-existing CD8+ T-cell memory pools can provide heterologous immunity against distinct influenza viruses, it is important to understand influenza-specific CD8+ T-cell responses elicited by different LAIV regimens. In this study, we immunized mice intranasally (i.n.) with two different doses of live-attenuated PR8 virus (PR8 ts, H1N1), low and high, and then assessed protective efficacy by challenging animals with heterosubtypic X31-H3N2 virus at 6 weeks post-vaccination...
November 2, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902339/progressive-glycosylation-of-the-hemagglutinin-of-avian-influenza-h5n1-modulates-virus-replication-virulence-and-chicken-to-chicken-transmission-without-significant-impact-on-antigenic-drift
#16
El-Sayed M Abdelwhab, Jutta Veits, Kerstin Tauscher, Mario Ziller, Christian Grund, Mohamed K Hassan, Momtaz Shaheen, Timm C Harder, Jens P Teifke, Jürgen Stech, Thomas C Mettenleiter
Highly pathogenic H5N1 avian influenza virus (A/H5N1) devastated the poultry industry and continues to pose a pandemic threat. Studying the progressive genetic changes in A/H5N1 after long term circulation in poultry may help to better understand A/H5N1 biology in birds. A/H5N1 clade 2.2.1.1 antigenic drift viruses have been isolated from vaccinated commercial poultry in Egypt. They exhibit a peculiar stepwise accumulation of glycosylation sites (GS) in the hemagglutinin (HA) with viruses carrying, beyond the conserved 5 GS, additional GS at amino acid residues 72, 154, 236 and 273 resulting in 6, 7, 8 or 9 GS in the HA...
October 28, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27899226/virospot-microneutralization-assay-for-antigenic-characterization-of-human-influenza-viruses
#17
Carel A van Baalen, Rienk E Jeeninga, Germaine H W M Penders, Brenda van Gent, Ruud van Beek, Marion P G Koopmans, Guus F Rimmelzwaan
The hemagglutination inhibition (HI) assay has been used for the antigenic characterization of influenza viruses for decades. However, the majority of recent seasonal influenza A viruses of the H3N2 subtype has lost the capacity to agglutinate erythrocytes of various species. The hemagglutination (HA) activity of other A(H3N2) strains is generally sensitive to the action of the neuraminidase inhibitor oseltamivir, which indicates that the neuraminidase and not the hemagglutinin is responsible for the HA activity...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27898629/influenza-like-illness-diagnosis-and-management-in-the-acute-care-setting
#18
Sharon G Humiston, Thuylinh N Pham
During influenza season, acute respiratory illness due to influenza is difficult to distinguish from other influenza-like illnesses, but testing should be reserved for situations when timely results will influence management or infection control measures. Immunization status and timing of disease onset notwithstanding, a neuraminidase inhibitor should be offered immediately for certain high-risk children; neuraminidase inhibitor treatment should be considered if shorter illness is warranted or an at-risk sibling may be protected...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27897990/how-to-meet-the-last-oie-expert-surveillance-panel-recommendations-on-equine-influenza-ei-vaccine-composition-a-review-of-the-process-required-for-the-recombinant-canarypox-based-ei-vaccine
#19
REVIEW
Romain Paillot, Nicola L Rash, Dion Garrett, Leah Prowse-Davis, Fernando Montesso, Ann Cullinane, Laurent Lemaitre, Jean-Christophe Thibault, Sonia Wittreck, Agnes Dancer
Vaccination is highly effective to prevent, control, and limit the impact of equine influenza (EI), a major respiratory disease of horses. However, EI vaccines should contain relevant equine influenza virus (EIV) strains for optimal protection. The OIE expert surveillance panel annually reviews EIV evolution and, since 2010, the use of Florida clade 1 and 2 sub-lineages representative vaccine strains is recommended. This report summarises the development process of a fully- updated recombinant canarypox-based EI vaccine in order to meet the last OIE recommendations, including the vaccine mode of action, production steps and schedule...
November 25, 2016: Pathogens
https://www.readbyqxmd.com/read/27895132/protection-against-streptococcus-pneumoniae-invasive-pathogenesis-by-a-protein-based-vaccine-is-achieved-by-suppression-of-nasopharyngeal-bacterial-density-during-influenza-a-virus-co-infection
#20
M Nadeem Khan, Qingfu Xu, Michael E Pichichero
An increase in Streptococcus pneumoniae (Spn) nasopharyngeal (NP) colonization density during a viral co-infection initiates pathogenesis. To mimic natural Spn pathogenesis, we commensally colonized the NP of adult C57BL/6 mice with Spn serotypes (STs) 6A or 8, and then co-infected with mouse-adapted H1N1 influenza A virus (PR/8/34). Spn established effective commensal colonization and Influenza co-infection caused Spn NP density to increase, resulting in bacteremia and mortality. We then studied histidine triad protein D (PhtD), a Spn adhesin vaccine candidate, for its ability to prevent invasive Spn disease in adult and infant mice...
November 28, 2016: Infection and Immunity
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