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glomerulonephritis CKD SLE

Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi
Lupus nephritis is major manifestation of systemic lupus erythematosus and could cause nephrotic syndrome or chronic kidney disease might lead to end-stage renal failure. The pathogenesis of macrophage as well as lymphocyte impairment had been described in lupus nephritis. The interstitial macrophage accumulation and interstitial change or fibrosis is more important than glomerular immunoglobulin deposition or glomerular macrophage accumulation in terms of renal outcome and survival proportion. The expressions of macrophage associated proteins such as CCL2/MCP-1, MIP-1 family and their receptors, CCR2, CCR1 and CCR5 are major target of therapeutic strategy for improving renal illness...
2015: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Onss Ali Saheb Al-Omairi
INTRODUCTION: Systemic lupus erythematosus (SLE) is an unpredictable autoimmune systemic disorder that often involves the kidney. In this study, we aimed to assess the clinical characteristics, pathological findings, and therapeutic response of children presenting with lupus nephritis (LN). METHODS: We retrospectively studied 50 children with SLE admitted to the pediatric nephrology departments of four teaching hospitals in Baghdad between December 2009 and December 2011...
May 2014: Arab Journal of Nephrology and Transplantation
Gh Gluhovschi, Silvia Velciov, Ligia Petrica, Cristina Gluhovschi
The kidneys, as an integral part of the body, are in close functional relationship with other organs. Dysfunction of the relationship with one organ will affect the kidney. Chronic kidney disease (CKD) leads in time to alteration of the relationship of the kidney with other organs, sometimes with severe consequences. Thus, cardiovascular involvement in CKD leads to increased severity of CKD, with an increase in mortality rate. At present, the relationship between the kidney and the lung has been less studied...
April 2014: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
N Ghahramani
Occupational exposure to heavy metals, organic solvents and silica is associated with a variety of renal manifestations. Improved understanding of occupational renal disease provides insight into environmental renal disease, improving knowledge of disease pathogenesis. Silica (SiO2) is an abundant mineral found in sand, rock, and soil. Workers exposed to silica include sandblasters, miners, quarry workers, masons, ceramic workers and glass manufacturers. New cases of silicosis per year have been estimated in the US to be 3600-7300...
July 2010: International Journal of Occupational and Environmental Medicine
Mervat El-Ansary, Gamal Saadi, Samah M Abd El-Hamid
AIM: Stem cell (SC) therapy for chronic kidney disease (CKD) is urgently needed. The use of mesenchymal stem cells (MSC) is a possible new therapeutic modality. Our work aimed to isolate human MSC from adult bone marrow to improve kidney functions in CKD patients. METHODS: In our study 30 patients with impaired kidney function were included, their ages ranged from 22 to 68 years. They included 10 inactive glomerulonephritis patients due to systemic lupus erythromatosus (SLE) (group I), 10 renal transplantation cases (group II) and 10 patients of other aetiologies as the control group...
September 2012: Nephrology
Haruyoshi Yoshida
I started my life as a medical doctor at Amagasaki Prefectural Hospital after graduation from the Faculty of Medicine, Kyoto University in September 1971. I joined the newly established section of nephrology in the second year. The chief was Dr. Kazuro Kanatsu who had just moved from Kyoto University at the time of the campus disturbances. Dr. Kanatsu not only oriented me in clinical nephrology, but also guided me in medical research. I used to go to the laboratory of Dr. Tadao Tamura, Kyoto University once a week to learn renal biopsy study...
February 2012: Rinsho Byori. the Japanese Journal of Clinical Pathology
Shelly L Vaden
Glomerular diseases are a leading cause of chronic kidney disease in dogs but seem to be less common in cats. Glomerular diseases are diverse, and a renal biopsy is needed to determine the specific glomerular disease that is present in any animal. Familial glomerulopathies occur in many breeds of dogs. However, most dogs with glomerular disease have acquired glomerular injury that is either immune-complex mediated or due to systemic factors, both of which are believed to be the result of a disease process elsewhere in the body (i...
August 2011: Topics in Companion Animal Medicine
Stacy Ardoin, Daniel J Birmingham, Paul L Hebert, Chack-Yung Yu, Brad H Rovin, Lee A Hebert
OBJECTIVE: Published criteria on the degree of proteinuria increase that defines a proteinuric flare in systemic lupus erythematosus (SLE) with glomerulonephritis (GN) vary widely, likely because they are not evidence based, but are largely based on expert opinion. Ideally, the threshold for proteinuric flare should be set sufficiently high that spontaneous variation in proteinuria does not likely explain the increase, but not so high that the patient needlessly experiences prolonged severe proteinuria before a flare is declared and therapy is increased...
July 2011: Arthritis and Rheumatism
R S Barsoum
Glomerulonephritis (GN) still enjoys a high rank as a cause of chronic kidney disease (CKD) worldwide. Its burden is particularly manifest in disadvantaged populations, with a proportional contribution up to 6-folds compared to that in the USA. There are several overlapping risk factors that render a particular population "disadvantaged" in this respect. It is envisaged that these may be categorized into a triad of genetic, climatic and socioeconomic factors. An attempt is made to dissect the impact of each of these factors, which combine in different proportions in different populations thereby explaining regional disparity in the epidemiology, clinical manifestations and outcomes of CKD...
November 2010: Clinical Nephrology
Mohamed B Abdelraheem, El-Tigani M A Ali, Reem M Mohamed, Einas G Hassan, Osman A Abdalla, Salwa O Mekki, B M Yousif, Alan R Watson
Glomerular diseases are a common cause of chronic kidney disease (CKD) in many countries. The pattern of glomerular diseases has been reported in adult Sudanese patients but there has been no previous study on Sudanese children. The aim of this study is to describe the pattern of glomerular diseases in Sudanese children from a clinico-pathological perspective. We retrospectively reviewed the clinical records of 321 children seen with nephritis/nephrosis at the Pediatric Nephrology Unit, Soba University Hospital and Dr...
July 2010: Saudi Journal of Kidney Diseases and Transplantation
Ulf H Beier, Cynthia Green, Kevin E Meyers
Adolescent patients who require the care of a nephrologist present with a variety of challenges. For the treating physician, it is important to be competent in relevant principles of adolescent physiology, such as somatic growth and puberty. It is also essential to be familiar with the stages of adolescent emotional and intellectual development, and their influence on behavior and adherence. Patients transitioning from pediatric nephrology may experience difficulties adjusting to the adult care system. Although the renal pathology of adolescents has more in common with that of adults than that of prepubertal children, there are unique epidemiological, diagnostic, and treatment approaches to these patients that should be considered...
February 2010: Kidney International
Prayong Vachvanichsanong, Pornsak Dissaneewate, Edward McNeil
We have retrospectively reviewed the records of children aged >1 month to 16 years who had been referred to the Department of Pediatrics of Prince of Songkla University's Faculty of Medicine, a tertiary referral center in Thailand, between 1982 and 2005 and subsequently diagnosed with chronic kidney disease (CKD). Our aim was to evaluate the prevalence and etiology of CKD in southern Thailand. There were 101 cases of CKD, with one case each diagnosed in 1988, 1989 and 1993, respectively, and 98 cases diagnosed between 1994 and 2005...
July 2008: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ashton Chen, Rachel Frank, Suzanne Vento, Virginia Crosby, Manju Chandra, Bernard Gauthier, Elsa Valderrama, Howard Trachtman
BACKGROUND: Idiopathic membranous nephropathy (IMN) is one of the most common causes of primary nephrotic syndrome in adults. However, it is a relatively rare entity in the pediatric population and there is a paucity of data about the incidence, prognosis, and optimal treatment of IMN in children and adolescents. We conducted this study to evaluate pediatric patients with IMN in order to clarify the presentation, response to therapy, and clinical outcome. METHODS: A retrospective chart review was performed on patients identified with biopsy-proven IMN between 1988-2005...
August 6, 2007: BMC Nephrology
Saumya Panda, Debabrata Bandyopadhyay, Avijit Tarafder
BACKGROUND: Nephrogenic fibrosing dermopathy (NFD) is a newly proposed clinical entity resembling scleromyxedema. This is mainly found in patients with chronic renal failure who have undergone hemodialysis. Nearly all cases have been reported in the Western population. OBJECTIVE: We sought to assess whether NFD cases occurred in a non-Western population and to ascertain the frequency, clinical characteristics, histopathology, and natural history of the condition in the event of its occurrence...
January 2006: Journal of the American Academy of Dermatology
Jennifer R Timoshanko, Peter G Tipping
Each year, worldwide, there is an increasing number of patients with chronic kidney disease that progress to end-stage renal disease. Glomerulonephritis (GN) is the commonest single cause of end-stage renal failure in the world. GN can be a manifestation of primary renal injury or may be a secondary feature of a systemic disease process, for example Systemic Lupus Erythematosus (SLE) and Anti-Neutrophilic Cytoplasmic Antibody (ANCA) associated vasculitis. Understanding of the immunopathogenesis of GN has advanced considerably over the last 25 years, particularly the immune system's role...
June 2005: Current Drug Targets. Inflammation and Allergy
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