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https://www.readbyqxmd.com/read/29489673/ultrasonographic-features-and-clinicopathologic-characteristics-of-macrofollicular-variant-papillary-thyroid-carcinoma
#1
Yong Sang Lee, Soo Young Kim, Soon Won Hong, Seok-Mo Kim, Bup-Woo Kim, Hang-Seok Chang, Cheong Soo Park
Macrofollicular variant papillary thyroid carcinoma (MFV-PTC) is defined as papillary thyroid carcinoma with macrofollicles of >200 μm in more than 50% of the cross-sectional area of the specimen. The aim of this study was to evaluate the clinicopathologic characteristics of the MFV-PTC treated in the Yonsei University College of Medicine.Between September 2007 and July 2012, 18,697 patients with PTC were treated in our institution. Of these, 10 patients (0.05%) were diagnosed as the MFV-PTC in final pathologic report...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29434957/experience-based-surgical-approach-to-pancreatic-mucinous-cystic-neoplasms-with-ovarian-type-stroma
#2
Chang Moo Kang, Akira Matsushita, Ho Kyoung Hwang, Yoko Matsuda, Hyunki Kim, Yoshiharu Nakamura, Woo Jung Lee
The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29370777/neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-can-predict-the-severity-of-gallstone-pancreatitis
#3
Seung Kook Cho, Saehyun Jung, Kyong Joo Lee, Jae Woo Kim
BACKGROUND: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) predict severity in various diseases. In this study, we evaluated the value of NLR and PLR as prognostic factors in acute pancreatitis (AP). METHODS: Patients with AP were prospectively enrolled from March 2014 to September 2016 at Yonsei University Wonju College of Medicine. NLR and PLR were obtained at admission and were compared with other known prognostic scoring systems...
January 25, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29335093/changes-in-biomechanically-corrected-intraocular-pressure-and-dynamic-corneal-response-parameters-before-and-after-transepithelial-photorefractive-keratectomy-and-femtosecond-laser-assisted-laser-in-situ-keratomileusis
#4
Hun Lee, Cynthia J Roberts, Tae-Im Kim, Renato Ambrósio, Ahmed Elsheikh, David Sung Yong Kang
PURPOSE: To evaluate the changes in biomechanically corrected intraocular pressure (IOP) and new dynamic corneal response parameters measured by a dynamic Scheimpflug analyzer before and after transepithelial photorefractive keratectomy (PRK) and femtosecond laser-assisted laser in situ keratomileusis (LASIK). SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective case series. METHODS: Medical records of patients having transepithelial PRK or femtosecond-assisted LASIK were examined...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29331886/anti-cancer-effects-of-hnha-and-lenvatinib-by-the-suppression-of-emt-mediated-drug-resistance-in-cancer-stem-cells
#5
Yong Sang Lee, Seok-Mo Kim, Bup-Woo Kim, Ho Jin Chang, Soo Young Kim, Cheong Soo Park, Ki Cheong Park, Hang-Seok Chang
Anaplastic thyroid cancer (ATC) constitutes less than 2% of total thyroid cancers but accounts for 20-40% of thyroid cancer-related deaths. Cancer stem cell drug resistance represents a primary factor hindering treatment. This study aimed to develop targeted agents against thyroid malignancy, focusing on individual and synergistic effects of HNHA (histone deacetylase), lenvatinib (FGFR), and sorafenib (tyrosine kinase) inhibitors. Patients with biochemically and histologically proven papillary thyroid cancer (PTC) and ATC were included...
February 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29312707/rare-causes-of-hyperbilirubinemia-after-lung-transplantation-our-experience-at-a-single-center
#6
Su Hwan Lee, Moo Suk Park, Jin Gu Lee, Joo Han Song, Kyung Soo Chung, Ji Ye Jung, Eun Young Kim, Young Sam Kim, Se Kyu Kim, Joon Chang, Hyo Chae Paik, Song Yee Kim
Background: Lung transplantation is the last treatment option for end-stage lung disease, and the number of lung transplantations has been steadily increasing. Hyperbilirubinemia is a rare complication after lung transplantation. The aim of this study was to review rare causes of hyperbilirubinemia after lung transplantation at our center. Methods: In this single-center study, we retrospectively reviewed the records of 116 consecutive lung transplantation patients who underwent lung transplantation at Severance Hospital and Gangnam Severance Hospital of Yonsei University College of Medicine in South Korea between December 22, 2010 and January 1, 2016...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28982042/evaluation-of-clinical-sensitivity-and-specificity-of-hepatitis-b-virus-hbv-hepatitis-c-virus-and-human-immunodeficiency-virus-1-by-cobas-mpx-detection-of-occult-hbv-infection-in-an-hbv-endemic-area
#7
Jihye Ha, Younhee Park, Hyon-Suk Kim
BACKGROUND: Transfusion-transmitted infectious diseases remain a major concern for blood safety, particularly with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Nucleic acid testing (NAT) in donor screening shortens the serologically negative window period and reduces virus transmission. The cobas MPX (Roche Molecular Systems, Inc., Branchburg, New Jersey) is a recently developed multiplex qualitative PCR system that enables the simultaneous detection of HBV, HCV, and HIV with improved sensitivity and throughput using cobas 6800 and 8800 instruments...
November 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28682944/a-simplified-mortality-score-using-delta-neutrophil-index-and-the-thrombotic-microangiopathy-score-for-prognostication-in-critically-ill-patients
#8
Eun K Goag, Jong W Lee, Yun H Roh, Ah Y Leem, Song Y Kim, Joo H Song, Eun Y Kim, Ji Y Jung, Moo S Park, Young S Kim, Se K Kim, Joon Chang, Kyung S Chung
BACKGROUND: This study was conducted to assess the prognostic value of a simplified mortality score (SMS) using the delta neutrophil index (DNI) and thrombotic microangiopathy (TMA) score, both easily obtained from the complete blood count, to identify critically ill patients at high risk of death. METHODS: This was a retrospective study performed in the medical ICU at Yonsei University College of Medicine from June 2015 to February 2016. The primary end point was 28-day all-cause mortality...
January 2018: Shock
https://www.readbyqxmd.com/read/28677336/predictive-value-of-apolipoprotein-b-and-a-i-ratio-in-severe-acute-pancreatitis
#9
Ji Hye Huh, Saehyun Jung, Seung Kook Cho, Kyong Joo Lee, Jae Woo Kim
BACKGROUND AND AIM: Severe acute pancreatitis (SAP) has considerable mortality and morbidity rates. Although many indices have been developed to classify the severity of acute pancreatitis (AP), an optimal method for predicting SAP has not been identified. The ratio of apolipoprotein B to A-I (apoB/A-I) is associated with metabolic syndrome and inflammatory status. This study investigated the association between severity of AP and serum apoB/A-I ratio. METHODS: Patients with AP were prospectively enrolled at Yonsei University Wonju College of Medicine from March 2015 to August 2016...
February 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28366363/comparison-of-clinical-outcomes-between-wavefront-optimized-versus-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-for-myopic-astigmatism
#10
Ikhyun Jun, David Sung Yong Kang, Jerry Tan, Jin Young Choi, Woon Heo, Joo Young Kim, Min Goo Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate and compare the clinical outcomes, including visual acuity, refractive errors, and aberrations, between aberration-free transepithelial photorefractive keratectomy (PRK) and corneal wavefront-guided transepithelial PRK in eyes with myopic astigmatism. SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective comparative case series. METHODS: Patients with myopic astigmatism were treated with aberration-free transepithelial PRK or corneal wavefront-guided transepithelial PRK using a 1050 Hz high-repetition excimer laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28289669/laparoscopic-resection-of-retroperitoneal-benign-neurilemmoma
#11
Jung Hwan Ji, Joon Seong Park, Chang Moo Kang, Dong Sup Yoon, Woo Jung Lee
PURPOSE: The aim of this study was to verify that laparoscopic resection for treating retroperitoneal benign neurilemmoma (NL) is expected to be favorable for complete resection of tumor with technical feasibility and safety. METHODS: We retrospectively analyzed 47 operations for retroperitoneal neurogenic tumor at Yonsei University College of Medicine, Severance Hospital and Gangnam Severance Hospital between January 2005 and September 2015. After excluding 21 patients, the remaining 26 were divided into 2 groups: those who underwent open surgery (OS) and those who underwent laparoscopic surgery (LS)...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28220819/the-cutoff-value-of-ossification-of-posterior-longitudinal-ligament-opll-for-early-diagnosis-of-myelopathy-using-somatosensory-evoked-potential-in-cervical-opll-patients
#12
S Y Yoon, T H Park, N L Eun, Y G Park
STUDY DESIGN: Retrospective study. OBJECTIVES: The objective of this study was to find out whether ossification of posterior longitudinal ligament (OPLL) characteristics, including size, shape and subtype, can be used to diagnose myelopathy using somatosensory evoked potential (SEP) in cervical OPLL patients. SETTING: Yonsei University College of Medicine, Seoul, Korea. METHODS: We retrospectively reviewed the medical records of 153 cervical OPLL patients who underwent SEP study...
June 2017: Spinal Cord
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#13
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27864713/a-prospective-randomized-study-for-efficacy-of-an-uncovered-double-bare-metal-stent-compared-to-a-single-bare-metal-stent-in-malignant-biliary-obstruction
#14
RANDOMIZED CONTROLLED TRIAL
Hyun Jik Lee, Moon Jae Chung, Jeong Yup Park, Seung Woo Park, Chung Mo Nam, Si Young Song, Seungmin Bang
BACKGROUND AND AIMS: A biliary self-expandable metal stent (SEMS) is commonly used to relieve malignant biliary obstruction. The aim of this study was to compare the efficacy of a conventional uncovered SEMS with that of a newly developed uncovered double bare metal stent in reducing the risk of stent occlusion caused by tumor ingrowth. PATIENTS AND METHODS: We performed a prospective, open-labeled, randomized trial in 71 patients at Severance Hospital, Yonsei University College of Medicine from June 2013 to June 2014...
August 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27687849/heroes-of-peer-review-hyongbum-henry-kim
#15
Hyongbum Kim
Peer reviewers are the unsung heroes of science. We celebrate reviewers through a series of interviews with people who have made particularly strong recent contributions to Genome Biology as reviewers. The first interview is with Hyongbum (Henry) Kim, an Associate Professor at Yonsei University College of Medicine in South Korea.
September 29, 2016: Genome Biology
https://www.readbyqxmd.com/read/27388671/stratified-analysis-of-800-asian-patients-after-robot-assisted-radical-prostatectomy-with-a-median-64-months-of-follow-up
#16
Ali Abdel Raheem, Dae Keun Kim, Glen Denmer Santok, Ibrahim Alabdulaali, Byung Ha Chung, Young Deuk Choi, Koon Ho Rha
OBJECTIVE: To report the 5-year oncological outcomes of robot-assisted radical prostatectomy from the largest series ever reported from Asia. METHODS: A retrospective analysis of 800 Asian patients who were treated with robot-assisted radical prostatectomy from July 2005 to May 2010 in the Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea was carried out. The primary end-point was to evaluate the biochemical recurrence...
September 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27373396/photorefractive-keratectomy-combined-with-corneal-wavefront-guided-and-hyperaspheric-ablation-profiles-to-correct-myopia
#17
Hun Lee, Si Yoon Park, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate the effects of photorefractive keratectomy (PRK) combined with corneal wavefront-guided ablation profiles and hyperaspheric ablation profiles on changes in higher-order aberrations (HOAs). SETTING: Yonsei University College of Medicine and Eyereum Clinic, Seoul, South Korea. DESIGN: Comparative observational case series. METHODS: Medical records of patients who had corneal wavefront-guided hyperaspheric PRK, corneal wavefront-guided mild-aspheric PRK, or non-corneal wavefront-guided mild-aspheric PRK were analyzed...
June 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27305847/association-between-level-of-fibrosis-rather-than-antiviral-regimen-and-outcomes-of-patients-with-chronic-hepatitis-b
#18
Hye Soo Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Ki Jun Song, Jung Won Park, Yeong Jin Kim, Oidov Baatarkhuu, Kwang-Hyub Han, Sang Hoon Ahn
BACKGROUND & AIMS: We performed a propensity-score matched analysis to investigate whether entecavir, compared with lamivudine, can reduce risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B after adjusting for level of fibrosis. METHODS: We performed a retrospective study of 1079 patients with chronic hepatitis B who received first-line therapy with lamivudine (n = 435) or entecavir (n = 644) from 2006 through 2013. Only patients with available liver stiffness value measured by transient elastography were recruited...
November 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26815245/in-errata
#19
(no author information available yet)
No abstract text is available yet for this article.
February 2016: Pain Physician
https://www.readbyqxmd.com/read/26512784/intraoperative-diagnosis-support-tool-for-serous-ovarian-tumors-based-on-microarray-data-using-multicategory-machine-learning
#20
Jee Soo Park, Soo Beom Choi, Hee Jung Kim, Nam Hoon Cho, Sang Wun Kim, Young Tae Kim, Eun Ji Nam, Jai Won Chung, Deok Won Kim
OBJECTIVES: Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diagnosing SBOTs with accuracy of 48% to 79%. Using DNA microarray technology, we designed multicategory classification models to support frozen-section diagnosis within 30 minutes. MATERIALS AND METHODS: We systematically evaluated 6 machine learning algorithms and 3 feature selection methods using 5-fold cross-validation and a grid search on microarray data obtained from the National Center for Biotechnology Information...
January 2016: International Journal of Gynecological Cancer
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