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https://www.readbyqxmd.com/read/28982042/evaluation-of-clinical-sensitivity-and-specificity-of-hepatitis-b-virus-hbv-hepatitis-c-virus-and-human-immunodeficiency-virus-1-by-cobas-mpx-detection-of-occult-hbv-infection-in-an-hbv-endemic-area
#1
Jihye Ha, Younhee Park, Hyon-Suk Kim
BACKGROUND: Transfusion-transmitted infectious diseases remain a major concern for blood safety, particularly with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Nucleic acid testing (NAT) in donor screening shortens the serologically negative window period and reduces virus transmission. The cobas MPX (Roche Molecular Systems, Inc., Branchburg, New Jersey) is a recently developed multiplex qualitative PCR system that enables the simultaneous detection of HBV, HCV, and HIV with improved sensitivity and throughput using cobas 6800 and 8800 instruments...
September 21, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28682944/a-simplified-mortality-score-using-delta-neutrophil-index-and-the-thrombotic-microangiopathy-score-for-prognostication-in-critically-ill-patients
#2
Eun Kyong Goag, Jong Wook Lee, Yun Ho Roh, Ah Young Leem, Song Yee Kim, Joo Han Song, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung
BACKGROUND: This study was conducted to assess the prognostic value of a simplified mortality score (SMS) using the delta neutrophil index (DNI) and thrombotic microangiopathy (TMA) score, both easily obtained from the complete blood count, to identify critically ill patients at high risk of death. METHODS: This was a retrospective study performed in the medical ICU at Yonsei University College of Medicine from June 2015 to February 2016. The primary end-point was 28-day all-cause mortality...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28677336/apolipoprotein-b-and-a-i-ratio-predicts-severe-acute-pancreatitis
#3
Ji Hye Huh, Saehyun Jung, Seung Kook Cho, Kyong Joo Lee, Jae Woo Kim
BACKGROUND AND AIM: Severe acute pancreatitis (SAP) has considerable mortality and morbidity rates. Although many indices have been developed to classify the severity of acute pancreatitis (AP), an optimal method for predicting SAP has not been identified. The ratio of apolipoprotein B to A-I (apoB/A-I) is associated with metabolic syndrome and inflammatory status. This study investigated the association between severity of AP and serum apoB/A-I ratio. METHODS: Patients with AP were prospectively enrolled at Yonsei University Wonju College of Medicine from March 2015 to August 2016...
July 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28366363/comparison-of-clinical-outcomes-between-wavefront-optimized-versus-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-for-myopic-astigmatism
#4
Ikhyun Jun, David Sung Yong Kang, Jerry Tan, Jin Young Choi, Woon Heo, Joo Young Kim, Min Goo Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate and compare the clinical outcomes, including visual acuity, refractive errors, and aberrations, between aberration-free transepithelial photorefractive keratectomy (PRK) and corneal wavefront-guided transepithelial PRK in eyes with myopic astigmatism. SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective comparative case series. METHODS: Patients with myopic astigmatism were treated with aberration-free transepithelial PRK or corneal wavefront-guided transepithelial PRK using a 1050 Hz high-repetition excimer laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28289669/laparoscopic-resection-of-retroperitoneal-benign-neurilemmoma
#5
Jung Hwan Ji, Joon Seong Park, Chang Moo Kang, Dong Sup Yoon, Woo Jung Lee
PURPOSE: The aim of this study was to verify that laparoscopic resection for treating retroperitoneal benign neurilemmoma (NL) is expected to be favorable for complete resection of tumor with technical feasibility and safety. METHODS: We retrospectively analyzed 47 operations for retroperitoneal neurogenic tumor at Yonsei University College of Medicine, Severance Hospital and Gangnam Severance Hospital between January 2005 and September 2015. After excluding 21 patients, the remaining 26 were divided into 2 groups: those who underwent open surgery (OS) and those who underwent laparoscopic surgery (LS)...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28220819/the-cutoff-value-of-ossification-of-posterior-longitudinal-ligament-opll-for-early-diagnosis-of-myelopathy-using-somatosensory-evoked-potential-in-cervical-opll-patients
#6
S Y Yoon, T H Park, N L Eun, Y G Park
STUDY DESIGN: Retrospective study. OBJECTIVES: The objective of this study was to find out whether ossification of posterior longitudinal ligament (OPLL) characteristics, including size, shape and subtype, can be used to diagnose myelopathy using somatosensory evoked potential (SEP) in cervical OPLL patients. SETTING: Yonsei University College of Medicine, Seoul, Korea. METHODS: We retrospectively reviewed the medical records of 153 cervical OPLL patients who underwent SEP study...
June 2017: Spinal Cord
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#7
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27864713/a-prospective-randomized-study-for-efficacy-of-an-uncovered-double-bare-metal-stent-compared-to-a-single-bare-metal-stent-in-malignant-biliary-obstruction
#8
Hyun Jik Lee, Moon Jae Chung, Jeong Yup Park, Seung Woo Park, Chung Mo Nam, Si Young Song, Seungmin Bang
BACKGROUND AND AIMS: A biliary self-expandable metal stent (SEMS) is commonly used to relieve malignant biliary obstruction. The aim of this study was to compare the efficacy of a conventional uncovered SEMS with that of a newly developed uncovered double bare metal stent in reducing the risk of stent occlusion caused by tumor ingrowth. PATIENTS AND METHODS: We performed a prospective, open-labeled, randomized trial in 71 patients at Severance Hospital, Yonsei University College of Medicine from June 2013 to June 2014...
August 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27687849/heroes-of-peer-review-hyongbum-henry-kim
#9
Hyongbum Kim
Peer reviewers are the unsung heroes of science. We celebrate reviewers through a series of interviews with people who have made particularly strong recent contributions to Genome Biology as reviewers. The first interview is with Hyongbum (Henry) Kim, an Associate Professor at Yonsei University College of Medicine in South Korea.
September 29, 2016: Genome Biology
https://www.readbyqxmd.com/read/27388671/stratified-analysis-of-800-asian-patients-after-robot-assisted-radical-prostatectomy-with-a-median-64-months-of-follow-up
#10
Ali Abdel Raheem, Dae Keun Kim, Glen Denmer Santok, Ibrahim Alabdulaali, Byung Ha Chung, Young Deuk Choi, Koon Ho Rha
OBJECTIVE: To report the 5-year oncological outcomes of robot-assisted radical prostatectomy from the largest series ever reported from Asia. METHODS: A retrospective analysis of 800 Asian patients who were treated with robot-assisted radical prostatectomy from July 2005 to May 2010 in the Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea was carried out. The primary end-point was to evaluate the biochemical recurrence...
September 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27373396/photorefractive-keratectomy-combined-with-corneal-wavefront-guided-and-hyperaspheric-ablation-profiles-to-correct-myopia
#11
Hun Lee, Si Yoon Park, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate the effects of photorefractive keratectomy (PRK) combined with corneal wavefront-guided ablation profiles and hyperaspheric ablation profiles on changes in higher-order aberrations (HOAs). SETTING: Yonsei University College of Medicine and Eyereum Clinic, Seoul, South Korea. DESIGN: Comparative observational case series. METHODS: Medical records of patients who had corneal wavefront-guided hyperaspheric PRK, corneal wavefront-guided mild-aspheric PRK, or non-corneal wavefront-guided mild-aspheric PRK were analyzed...
June 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27305847/association-between-level-of-fibrosis-rather-than-antiviral-regimen-and-outcomes-of-patients-with-chronic-hepatitis-b
#12
Hye Soo Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Ki Jun Song, Jung Won Park, Yeong Jin Kim, Oidov Baatarkhuu, Kwang-Hyub Han, Sang Hoon Ahn
BACKGROUND & AIMS: We performed a propensity-score matched analysis to investigate whether entecavir, compared with lamivudine, can reduce risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B after adjusting for level of fibrosis. METHODS: We performed a retrospective study of 1079 patients with chronic hepatitis B who received first-line therapy with lamivudine (n = 435) or entecavir (n = 644) from 2006 through 2013. Only patients with available liver stiffness value measured by transient elastography were recruited...
November 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26815245/in-errata
#13
(no author information available yet)
No abstract text is available yet for this article.
February 2016: Pain Physician
https://www.readbyqxmd.com/read/26512784/intraoperative-diagnosis-support-tool-for-serous-ovarian-tumors-based-on-microarray-data-using-multicategory-machine-learning
#14
Jee Soo Park, Soo Beom Choi, Hee Jung Kim, Nam Hoon Cho, Sang Wun Kim, Young Tae Kim, Eun Ji Nam, Jai Won Chung, Deok Won Kim
OBJECTIVES: Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diagnosing SBOTs with accuracy of 48% to 79%. Using DNA microarray technology, we designed multicategory classification models to support frozen-section diagnosis within 30 minutes. MATERIALS AND METHODS: We systematically evaluated 6 machine learning algorithms and 3 feature selection methods using 5-fold cross-validation and a grid search on microarray data obtained from the National Center for Biotechnology Information...
January 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/26470767/a-comparison-of-gastrointestinal-toxicities-between-intensity-modulated-radiotherapy-and-three-dimensional-conformal-radiotherapy-for-pancreatic-cancer
#15
COMPARATIVE STUDY
Kyong Joo Lee, Hong In Yoon, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung-Woo Park, Jin Sil Seong, Si Young Song
BACKGROUND/AIMS: Concurrent chemoradiotherapy (CCRT) is considered the treatment option for locally advanced pancreatic cancer, but accompanying gastrointestinal toxicities are the most common complication. With the introduction of three-dimensional conformal radiotherapy (3-D CRT) and intensity-modulated radiotherapy (IMRT), CCRT-related adverse events are expected to diminish. Here, we evaluated the benefits of radiation modalities by comparing gastrointestinal toxicities between 3-D CRT and IMRT...
March 2016: Gut and Liver
https://www.readbyqxmd.com/read/26446647/the-clinical-significance-of-the-right-para-oesophageal-lymph-nodes-in-papillary-thyroid-cancer
#16
Hojin Chang, Ri Na Yoo, Seok-Mo Kim, Bup-Woo Kim, Yong Sang Lee, Seung Chul Lee, Hang-Seok Chang, Cheong Soo Park
PURPOSE: Although guidelines indicate that routine dissection of the central lymph nodes in patients with thyroid carcinoma should include the right para-oesophageal lymph nodes (RPELNs), located between the right recurrent laryngeal nerve and the cervical oesophagus and posterior to the former, RPELN dissection is often omitted due to high risk of injuries to the recurrent laryngeal nerve and the right inferior parathyroid gland. MATERIALS AND METHODS: We retrospectively identified all patients diagnosed with papillary thyroid carcinoma who underwent total thyroidectomy with central lymph node dissection, including the RPELNs, between January 1, 2009 and December 31, 2013 at the Thyroid Cancer Center of Yonsei University College of Medicine, Seoul, Korea...
November 2015: Yonsei Medical Journal
https://www.readbyqxmd.com/read/26240504/clinical-association-of-thyroid-stimulating-hormone-receptor-antibody-levels-with-disease-severity-in-the-chronic-inactive-stage-of-graves-orbitopathy
#17
Young Jae Woo, Sun Young Jang, Tyler Hyung Taek Lim, Jin Sook Yoon
PURPOSE: To investigate associations between serum thyroid stimulating hormone (TSH) receptor antibody (TRAb) levels and Graves' orbitopathy (GO) activity/severity in chronic-stage GO and compare the performance of two newly-developed TRAb assays (third-generation TSH-binding inhibition immunoglobulin [TBII] assay versus Mc4 thyroid-stimulating immunoglobulin [TSI] bioassay). METHODS: This study is a retrospective review of medical charts and blood tests from Korean GO patients who first visited the departments of ophthalmology and endocrinology, Yonsei University College of Medicine from January 2008 to December 2011, were diagnosed with GO and Graves' hyperthyroidism, and were followed up for ≥18 months...
August 2015: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/26092366/comparison-of-3-marking-techniques-in-preoperative-assessment-of-toric-intraocular-lenses-using-a-wavefront-aberrometer
#18
COMPARATIVE STUDY
Young Jae Woo, Hun Lee, Hong Seok Kim, Eung Kweon Kim, Kyoung Yul Seo, Tae-im Kim
PURPOSE: To assess the accuracy of 3 corneal horizontal meridian marking techniques using the iTrace Surgical Workstation in preoperative assessment for toric intraocular lens (IOL) implantation. SETTING: Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea. DESIGN: Prospective comparative observational study. METHODS: Patients were allocated into 3 groups. Three techniques-marking with a nonpendular marker with a surgeon's direct visualization, slitlamp-assisted marking with a pendulum-attached marker, and slitlamp-assisted marking with a horizontal slit beam-were used to perform the horizontal meridian marking...
June 2015: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/26023672/clinical-features-of-thoracic-endometriosis-a-single-center-analysis
#19
Sun Mi Hwang, Chung Won Lee, Byung Seok Lee, Joo Hyun Park
OBJECTIVE: To analyze the diagnostic profiles and treatment outcomes of patients with thoracic endometriosis at a university hospital. METHODS: A retrospective review of medical records was performed for patients diagnosed with thoracic endometriosis at Gangnam Severance Hospital, Yonsei University College of Medicine, between January 2007 and January 2014. RESULTS: Fifteen patients (median age, 35 years; range, 23-48 years) were evaluated...
May 2015: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/25853473/early-intervention-in-thyroidectomy-scars-demographics-symptoms-and-prevention
#20
J U Shin, J H Park, S H Oh, J J Jeong, S Kang, K Nam, W Y Chung, J H Lee
OBJECTIVE: Although hypertrophic scars are cosmetically problematic for patients following thyroidectomy, the associated risk factors are not well defined. Our objective was to determine the factors associated with hypertrophic scar development following thyroidectomy. METHOD: A retrospective chart review was performed collecting data on sex, age, body mass index (BMI), operation site, skin characteristics (pigmentation, erythema, elasticity, and hydration), and clinical scar characteristics (itching, tightening, induration, adhesion, and oedema)...
April 2015: Journal of Wound Care
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