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Carotid intima media thickness

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https://www.readbyqxmd.com/read/29782650/predicting-obstructive-coronary-artery-disease-using-carotid-ultrasound-parameters-a-nomogram-from-a-large-real-world-clinical-data
#1
Na Wu, Xinghua Chen, Mingyang Li, Xiaolong Qu, Yueli Li, Weijia Xie, Long Wu, Ying Xiang, Yafei Li, Li Zhong
BACKGROUND: Carotid ultrasound is a non-invasive tool for risk assessment of coronary artery disease (CAD). There is no consensus on which carotid ultrasound parameter constitutes the best measurement of atherosclerosis. We investigated which model of carotid ultrasound parameters and clinical risk factors (CRF) have the highest predictive value for CAD. MATERIALS AND METHODS: We enrolled 2431 consecutive patients who have suspected CAD and underwent coronary angiography and carotid ultrasound with measurements of carotid intima-media thickness (CIMT), total number of plaques and areas of different types of plaques classified by echogenicity...
May 21, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29782259/-relationship-of-remodeling-of-carotid-arteries-and-left-ventricular-geometry-in-patients-with-chronic-glomerulonephritis
#2
I T Murkamilov, K A Aitbaev, A S Sarybaev, V V Fomin, I G Gordeev, Z R Rayimzhanov, N A Redjapova, F A Yusupov
PURPOSE: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage. MATERIALS AND METHODS: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR)...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29779266/associations-of-mental-health-with-cardiovascular-risk-phenotypes-and-adiposity-in-adolescence-a-cross-sectional-community-based-study
#3
Kate Lycett, Clare McNamara, Fiona K Mensah, David Burgner, Jessica A Kerr, Josh Muller, Melissa Wake
AIM: Cardiovascular disease and mental illness commonly co-occur in later life, but it is unknown how early these associations arise. We aimed to determine the extent to which: (i) childhood mental health is associated with functional and structural cardiovascular risk phenotypes and adiposity in late childhood/adolescence, and (ii) associations between mental health and cardiovascular phenotypes may be explained by differential body mass index. METHODS: This cross-sectional study drew on three longitudinal community-based cohort studies (two enriched for overweight/obesity) in metropolitan Melbourne, Australia, with harmonized follow-up in 2014...
May 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29779142/arousal-index-as-a-marker-of-carotid-artery-atherosclerosis-in-patients-with-obstructive-sleep-apnea-syndrome
#4
Mayumi Suzuki, Ken Shimamoto, Haruki Sekiguchi, Takamitsu Harada, Natsumi Satoya, Yuji Inoue, Kazuhiro Yamaguchi, Masatoshi Kawana
PURPOSE: It was shown in a previous cohort study that men with internal carotid artery (ICA) plaque, defined as focal wall thickness of ≥ 1.5 mm, had a threefold higher risk of stroke than those without plaque. We examined the relationship between arousal indices and sleep stages in patients with obstructive sleep apnea syndrome (OSAS) and carotid atherosclerosis. METHODS: Carotid atherosclerosis severity was evaluated using the maximal carotid wall intima-media thickness of the ICA (ICA-maxIMT) and plaque in 83 patients with OSAS...
May 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29778949/association-between-hyperhomocysteinemia-and-metabolic-syndrome-with-early-carotid-artery-atherosclerosis-a-cross-sectional-study-in-middle-aged-chinese-population
#5
Chengguo Liu, Xiaohui Sun, Hanli Lin, Ruizhi Zheng, Liansheng Ruan, Zhanhang Sun, Yimin Zhu
OBJECTIVES: Homocysteine is a modifiable, independent risk factor for cardiovascular disease. The association between hyperhomocysteinemia and metabolic syndrome with the presence of early carotid artery atherosclerosis remains unknown in middle-aged Chinese adults. METHODS: Chinese adults (n = 1607) of Han ethnicity, age 35 to 65 y, and living in their communities >2 y were surveyed. Hyperhomocysteinemia was defined as homocysteine concentrations >15 µmol/L...
March 21, 2018: Nutrition
https://www.readbyqxmd.com/read/29778925/deep-learning-strategy-for-accurate-carotid-intima-media-thickness-measurement-an-ultrasound-study-on-japanese-diabetic-cohort
#6
Mainak Biswas, Venkatanareshbabu Kuppili, Tadashi Araki, Damodar Reddy Edla, Elisa Cuadrado Godia, Luca Saba, Harman S Suri, Tomaž Omerzu, John R Laird, Narendra N Khanna, Andrew Nicolaides, Jasjit S Suri
MOTIVATION: The carotid intima-media thickness (cIMT) is an important biomarker for cardiovascular diseases and stroke monitoring. This study presents an intelligence-based, novel, robust, and clinically-strong strategy that uses a combination of deep-learning (DL) and machine-learning (ML) paradigms. METHODOLOGY: A two-stage DL-based system (a class of AtheroEdge™ systems) was proposed for cIMT measurements. Stage I consisted of a convolution layer-based encoder for feature extraction and a fully convolutional network-based decoder for image segmentation...
May 12, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29777608/osteocalcin-value-to-identify-subclinical-atherosclerosis-over-atherosclerotic-cardiovascular-disease-ascvd-risk-score-in-middle-aged-and-elderly-chinese-asymptomatic-men
#7
Yiting Xu, Xiaojing Ma, Qin Xiong, Xueli Zhang, Yun Shen, Yuqian Bao
BACKGROUND: Our study examined whether osteocalcin contributed to identifying carotid intima-media thickness (C-IMT) over the atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: We recruited 618 middle-aged and elderly men from communities in Shanghai. Serum osteocalcin levels were determined using an electrochemiluminescence immunoassay. C-IMT was measured by ultrasonography. RESULTS: The study included 245 men with low ASCVD risk and 373 men with moderate-to-high ASCVD risk...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29777240/serum-25-hydroxyvitamin-d-and-cardiovascular-disease-risk-factors-in-women-with-excessive-weight-gain-during-pregnancy-and-in-their-offspring-at-age-5-6-years
#8
Gemma Carreras-Badosa, Cristina Armero-Bujaldón, Laia Solé-Amat, Anna Prats-Puig, Ferran Díaz-Roldán, Pilar Soriano-Rodriguez, Francis de Zegher, Lourdes Ibañez, Judit Bassols, Abel López-Bermejo
BACKGROUND/OBJECTIVE: Low 25-hydroxyvitamin D levels [25(OH)D] may increase the risk for cardiovascular disease (CVD). In pregnant women excessive weight gain and 25(OH)D deficiency are common complications and both could have deleterious consequences on their children. We aimed to study the relationship between serum 25(OH)D and CVD risk factors in pregnant women and in their offspring at school age. SUBJECTS/METHODS: Fasting serum 25(OH)D and its bioavailable fraction were quantified in 310 healthy pregnant women [with adequate (n = 113), insufficient (n = 113) and excessive (n = 84) weight gain]...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29774463/early-cardiovascular-manifestations-in-children-and-adolescents-with-autosomal-dominant-polycystic-kidney-disease-a-single-center-study
#9
Vasiliki Karava, Cherine Benzouid, Julien Hogan, Claire Dossier, André Pierre Denjean, Georges Deschênes
BACKGROUND: This study aims to describe the cardiovascular manifestations in children with autosomal dominant polycystic kidney disease (ADPKD) and detect their relation with kidney disease and type of gene mutation. METHODS: Twenty-one patients (7 to 19 years old) were included. Cardiovascular evaluation involved blood pressure (BP), indexed left ventricular mass (LVMI), pulse wave velocity (PWV), and carotid intima media thickness (cIMT) measurement. Patients were classified according to percentile reference values of these parameters in healthy children...
May 17, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29774373/cardiovascular-system-changes-in-rheumatoid-arthritis-patients-with-continued-low-disease-activity
#10
Małgorzata Biskup, Wojciech Biskup, Maria Majdan, Bożena Targońska-Stępniak
Systemic inflammation and disease activity seem to contribute to excessive prevalence of cardiovascular (CV) diseases (CVDs) in patients with rheumatoid arthritis (RA). The objective of the study was to assess chosen CV parameters in RA patients who have continuous low disease activity. The study group consisted of 70 RA patients without known CVD and 33 healthy controls, of a comparable age. All RA patients had continued low disease activity (DAS28 ≤ 3.2) from 2 to 7 years. The groups were assessed for: blood pressure, serum amino-terminal pro-brain natriuretic peptide (NT-proBNP), carotid intima media thickness (cIMT), electrocardiography (ECG), ejection fraction (EJ) and diastolic dysfunction (E/A ratio) in echocardiography...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29773828/single-nucleotide-polymorphisms-in-the-g-protein-coupled-receptor-kinase-5-grk5-gene-are-associated-with-plasma-ldl-cholesterol-levels-in-humans
#11
Stefan Z Lutz, Mathias Falcenberg, Fausto Machicao, Andreas Peter, Martin Kächele, Elko Randrianarisoa, Angela Lehn-Stefan, Robert Wagner, Jürgen Machann, Fritz Schick, Martin Heni, Axel Ullrich, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Konstantinos Kantartzis
Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in 2332 subjects at risk for type 2 diabetes. Total- and visceral fat mass were measured by magnetic resonance (MR) tomography and liver fat content by 1 H-MR spectroscopy...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773421/r46l-polymorphism-in-the-pcsk9-gene-relationship-to-lipid-levels-subclinical-vascular-disease-and-erectile-dysfunction
#12
Jose M Mostaza, Carlos Lahoz, Miguel A Salinero-Fort, Olaya de Dios, Elisa Castillo, Teresa González-Alegre, Francisca García-Iglesias, Eva Estirado, Fernando Laguna, Concesa Sabín, Silvia López, Victor Cornejo, Carmen de Burgos, Vanesa Sanchez, Carmen Garcés
BACKGROUND: The R46L variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been related to lipid levels and cardiovascular disease. OBJECTIVE: To evaluate the influence of this polymorphism on subclinical vascular disease and erectile dysfunction (ED). METHODS: We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness (IMT), and the ankle-brachial index, in 1188 adults free of cardiovascular disease, randomly selected from the population...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29773245/validation-of-an-open-source-tool-for-measuring-carotid-lumen-diameter-and-intima-media-thickness
#13
Hugo Luis Manterola, Lucas Lo Vercio, Alejandro Díaz, Mariana Del Fresno, Ignacio Larrabide
In low- and middle-income regions, a relatively large number of deaths occur from cardiovascular disease or stroke. Carotid intima-media thickness (cIMT) and carotid lumen diameter (cLD) are strong indicators of cardiovascular event risk and stenosis severity, respectively. The interactive open-source software described here, Cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis and treatment. Cimtool was validated using carotid phantoms and real images obtained using ultrasound...
May 14, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#14
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29770736/carotid-artery-stenosis-screening-where-are-we-now
#15
Rebecca Mortimer, Subramanian Nachiappan, David C Howlett
Stroke poses a significant burden on healthcare and is the second largest cause of death globally. Both medical and surgical interventions to reduce the risk of stroke in asymptomatic patients have been shown to be effective but identifying the target at risk population is more problematic. Screening for carotid artery stenosis offers one pathway for this, as there is some correlation between risk of stroke and extent of stenosis. Identification of patients who are at risk of cardiovascular disease as well as stroke, allows initiation of effective medical treatment of modifiable risk factors to address this risk...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29770339/red-blood-cell-distribution-width-is-associated-with-carotid-atherosclerosis-in-people-with-type-2-diabetes
#16
J S Nam, C W Ahn, S Kang, K R Kim, J S Park
Aims: Red cell distribution width (RDW) has been shown to be associated with cardiovascular diseases (CVD). The relationship between RDW and carotid intima-media thickness (C-IMT), a marker of subclinical atherosclerosis, has been inconsistent in subjects with cardiovascular risk factors. In this study, we investigated the relationship between RDW and carotid atherosclerosis in people with type 2 diabetes. Methods: Four hundred sixty-nine people with type 2 diabetes without history of cardiovascular or cerebrovascular diseases were enrolled...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29768162/-structural-and-functional-changes-of-blood-vessels-in-women-in-early-postmenopause-the-possibility-of-correction-of-the-revealed-violations
#17
S N Tolstov, I A Salov, A P Rebrov
AIM: To evaluate severity and pattern of structural and functional changes of vascular wall in early postmenopausal women receiving chronic treatment with a low-dose combination of 17β-estradiol (E2) 1 mg and drospirenone 2 mg (DRSP). Evaluation of structural and functional arterial remodeling might be important for assessment of cardiovascular risk in postmenopausal women. MATERIALS AND METHODS: The study included 162 early postmenopausal women with postmenopausal syndrome...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29766804/cyclophilin-a-a-predictive-biomarker-of-carotid-stenosis-in-cerebral-ischemic-stroke
#18
Chen-Shu Chang, Shih-Li Su, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Song-Shei Lin, Chin-San Liu
BACKGROUND: Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. METHOD: Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke...
May 16, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29763709/fenofibrate-effects-on-carotid-artery-intima-media-thickness-in-adults-with-type-2-diabetes-mellitus-a-field-substudy
#19
Jason A Harmer, Anthony C Keech, Anne-Sophie Veillard, Michael R Skilton, Gerald F Watts, David S Celermajer
AIM: Dyslipidemia in type 2 diabetes contributes to an increased risk of cardiovascular disease. Fenofibrate, a lipid-regulating peroxisome proliferator-activated receptor-α (PPARα) agonist, has been shown to reduce vascular complications in adults with type 2 diabetes. The mechanisms for such benefit, however, are not yet well understood. We examined the effects of fenofibrate on carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in adults with type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29761548/variation-of-carotid-intima-media-thickness-with-body-mass-index-in-healthy-adults-of-black-african-descent
#20
Adesola Abiodun Asaleye, Kolawole Thomas Braimoh, Olalekan Ibukun Oyinloye, Christianah Mopelola Asaleye, Adeleye Dorcas Omisore
OBJECTIVES: Studies have shown that common carotid intima media thickness (CIMT) measured by B-mode sonography increases with body mass index (BMI) among subjects with cardiovascular diseases in different populations. However, association of body fat and subclinical atherosclerosis in the absence of these cardiovascular diseases is understudied. We aimed to evaluate the correlation between BMI and CIMT in a healthy adult population of black African ancestry. METHODS: This is a cross-sectional prospective study in 300 consecutive apparently healthy subjects aged 18 to 70 years without history of hypertension, dyslipidemia, diabetes mellitus, and renal disease...
May 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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