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rivaroxaban in pulmonary arterial hypertension

Carolina Chic Acevedo, Francisco Velasco, Concepción Herrera
Rivaroxaban is a once-daily oral anticoagulant currently indicated for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It is also indicated for the prevention and treatment of venous or pulmonary thromboembolism. Despite the known advantages of rivaroxaban over standard therapy, this treatment is not exempt from bleeding. We present the case of a 51-year-old woman with arterial hypertension and paroxysmal atrial fibrillation anticoagulated with rivaroxaban 20 mg o...
September 2015: Future Cardiology
Mediha Ibrahim, Ajsza Matela, Shilpa Desouza, Joseph Mathew
Pleural Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Dense fibrous tissue may form over the pleural surface for a variety of reasons. Pleural fibrosis usually follows intense inflammation of the pleura; however, the mechanisms following the inflammatory process leading up to fibrosis are unclear.CASE PRESENTATION: A 60-year-old Liberian woman presented to our institution complaining of dyspnea and leg edema for 3 months...
October 1, 2014: Chest
Martina Delbeck, Katrin F Nickel, Elisabeth Perzborn, Peter Ellinghaus, Julia Strassburger, Raimund Kast, Volker Laux, Stefan Schäfer, Ralph T Schermuly, Georges von Degenfeld
AIMS: Anticoagulation with warfarin is recommended for the treatment of patients with pulmonary arterial hypertension (PAH). However, the therapeutic benefit of anticoagulation has not yet been demonstrated experimentally or clinically. Here, rivaroxaban, an oral, direct factor Xa (FXa) inhibitor, was compared with warfarin and enoxaparin in the prevention of right ventricular (RV) dysfunction and hypertrophy in the monocrotaline (MCT) model of pulmonary hypertension. METHODS AND RESULTS: Sprague-Dawley rats (n = 10 per group) were randomized to receive rivaroxaban, warfarin, enoxaparin, or placebo before receiving a subcutaneous injection of MCT 60 mg/kg or saline...
October 1, 2011: Cardiovascular Research
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