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https://www.readbyqxmd.com/read/27903250/effectiveness-of-bovine-derived-xenograft-versus-bioactive-glass-with-periodontally-accelerated-osteogenic-orthodontics-in-adults-a-randomized-controlled-clinical-trial
#1
Maha A Bahammam
BACKGROUND: Periodontally accelerated osteogenic orthodontics (PAOO) combines periodontal therapy with orthodontic therapy, which minimises treatment time. This study compared the effectiveness of a bovine-derived xenograft with that of bioactive glass when combined with PAOO for the treatment of adult patients with moderate crowding of the teeth. METHODS: In this prospective, single-masked clinical trial, 33 orthodontic patients (20 women, 13 men; mean age 21.2 ± 1...
November 30, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#2
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27897172/adaptation-and-external-validation-of-the-european-randomised-study-of-screening-for-prostate-cancer-risk-calculator-for-the-chinese-population
#3
P K Chiu, M J Roobol, D Nieboer, J Y Teoh, S K Yuen, S M Hou, M K Yiu, C F Ng
BACKGROUND: To adapt the well-performing European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator to the Chinese setting and perform an external validation. METHODS: The original ERSPC risk calculator 3 (RC3) for prostate cancer (PCa) and high-grade PCa (HGPCa) was applied to a development cohort of 3006 previously unscreened Hong Kong Chinese men with initial transrectal biopsies performed from 1997 to 2015, age 50-80 years, PSA 0.4-50 ng ml(-1) and prostate volume 10-150 ml...
November 29, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27893953/leveraging-telehealth-to-bring-volunteer-physicians-into-underserved-communities
#4
Lori Uscher-Pines, Robert Rudin, Ateev Mehrotra
Many disadvantaged communities lack sufficient numbers of local primary care and specialty physicians. Yet tens of thousands of physicians, in particular those who are retired or semiretired, desire meaningful volunteer opportunities. Multiple programs have begun to use telehealth to bridge the gap between volunteer physicians and underserved patients. In this brief, we describe programs that are using this model and discuss the promise and pitfalls. Physician volunteers in these programs report that the work can be fulfilling and exciting, a cutting-edge yet convenient way to remain engaged and contribute...
November 28, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27893694/the-safety-and-efficacy-of-vitamin-k-antagonist-in-atrial-fibrillation-patients-with-previous-ulcer-bleeding-long-term-results-from-a-multicenter-study
#5
Seung-Jun Lee, Jung-Hoon Sung, Jin-Bae Kim, Min-Soo Ahn, Hye Young Lee, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Jong-Yun Kim, Boyoung Joung
This study aimed to evaluate the safety and efficacy of vitamin K antagonist (VKA) in atrial fibrillation (AF) patients with previous ulcer bleeding.In this multicenter, retrospective analysis, clinical outcomes of 754 AF patients with a history of ulcer bleeding were evaluated. After ulcer treatment, 458 patients (61%) were treated with VKA, and the outcomes were compared to 296 patients (39%) without VKA.VKA treatment significantly increased major bleeding (7.3%/year vs 3.2%/year, P < 0.001), and reduced major adverse cardiac events (MACE) (5...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889277/evaluating-the-four-kallikrein-panel-of-the-4kscore-for-prediction-of-high-grade-prostate-cancer-in-men-in-the-canary-prostate-active-surveillance-study
#6
Daniel W Lin, Lisa F Newcomb, Marshall D Brown, Daniel D Sjoberg, Yan Dong, James D Brooks, Peter R Carroll, Matthew Cooperberg, Atreya Dash, William J Ellis, Michael Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Yingye Zheng
BACKGROUND: Diagnosis of Gleason 6 prostate cancer can leave uncertainty about the presence of undetected aggressive disease. OBJECTIVE: To evaluate the utility of a four kallikrein (4K) panel in predicting the presence of high-grade cancer in men on active surveillance. DESIGN, SETTING, AND PARTICIPANTS: Plasma collected before the first and subsequent surveillance biopsies was assessed for 718 men prospectively enrolled in the multi-institutional Canary PASS trial...
November 23, 2016: European Urology
https://www.readbyqxmd.com/read/27884850/comparative-effectiveness-and-safety-of-oral-anticoagulants-for-atrial-fibrillation-in-real-world-practice-a-population-based-cohort-study-protocol
#7
Anne Holbrook, Colin Dormuth, Richard Morrow, Agnes Lee, Sue Troyan, Guowei Li, Eleanor Pullenyegum
INTRODUCTION: Anticoagulants are arguably the most important drug family of all, based on the frequency and duration of their use, and the clinical importance and frequency of benefits and harms. Several direct acting oral anticoagulants (DOACs) have recently joined warfarin for the treatment of atrial fibrillation, with a resultant significant expansion in use of oral anticoagulants (OACs). Our objectives are to compare safety and effectiveness of DOACs versus warfarin in a full population where anticoagulation management is good and to identify which types of patients do better with DOACs versus warfarin and vice versa...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27872051/management-of-mild-hypertension-in-adults
#8
REVIEW
Anthony J Viera, Emily M Hawes
Elevated blood pressure is a common risk factor for cardiovascular disease and affects one in three adults. Blood pressure lowering drugs substantially reduce the risk of stroke, coronary heart disease, heart failure, and premature death, but most clinical trials showing benefits have primarily included patients with moderate to severe hypertension, known cardiovascular disease, or elevated risk of cardiovascular disease. The benefits of treating mild hypertension in patients without cardiovascular disease are less clear, but recent meta-analyses offer some insights...
November 21, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27865653/evaluation-of-school-based-dental-sealant-programs-an-updated-community-guide-systematic-economic-review
#9
REVIEW
Susan O Griffin, Shillpa Naavaal, Christina Scherrer, Mona Patel, Sajal Chattopadhyay
CONTEXT: A recently updated Community Guide systematic review of the effectiveness of school sealant programs (SSPs) still found strong evidence that SSPs reduced dental caries among schoolchildren. This follow-up systematic review updates SSP cost and benefit information from the original 2002 review. EVIDENCE ACQUISITION: Using Community Guide economic review methods, the authors searched the literature from January 2000 to November 20, 2014. The final body of evidence included 14 studies-ten from the current search and four with cost information from the 2002 review...
November 16, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27862911/effect-of-post-primary-percutaneous-coronary-intervention-bivalirudin-infusion-on-net-adverse-clinical-events-and-mortality-a-comprehensive-pairwise-and-network-meta-analysis-of-randomized-controlled-trials
#10
Rahman Shah, Khalid Matin, Kelly C Rogers, Sunil V Rao
OBJECTIVE: To compare the efficacies of various post-percutaneous coronary intervenetion (PCI) bivalirudin doses on net adverse clinical events (NACEs) and mortality. BACKGROUND: In primary PCI, lower risk of bleeding with bivalirudin (vs. unfractionated heparin [UFH]) is counterbalanced by an increased risk of acute stent thrombosis (ST). Several randomized clinical trials (RCTs) and a recent meta-analysis suggest that acute ST risk may be eliminated without compromising the bleeding benefit, but only if the full dose, not a low dose, of bivalirudin is continued post-PCI...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27860223/validation-of-risk-stratification-for-children-with-febrile-neutropenia-in-a-pediatric-oncology-unit-in-india
#11
Anirban Das, Amita Trehan, Sapna Oberoi, Deepak Bansal
PURPOSE: The study aims to validate a score predicting risk of complications in pediatric patients with chemotherapy-related febrile neutropenia (FN) and evaluate the performance of previously published models for risk stratification. PATIENTS AND METHODS: Children diagnosed with cancer and presenting with FN were evaluated in a prospective single-center study. A score predicting the risk of complications, previously derived in the unit, was validated on a prospective cohort...
November 15, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27857269/neuroendocrine-tumors-and-lanreotide-depot-clinical-considerations-and-nurse-and-patient-preferences
#12
Pamela Ryan, Alexandria T Phan, Daphne T Adelman, Michiko Iwasaki
BACKGROUND: Somatostatin analogs (SSAs) are a mainstay therapy for the treatment of carcinoid syndrome associated with neuroendocrine tumors (NETs). They are effective for a range of gastroenteropancreatic NETs (GEP-NETs). Lanreotide depot (Somatuline®) is an SSA that is approved for the treatment of GEP-NETs to improve progression-free survival (PFS). OBJECTIVES: The article reviews the efficacy, safety, and administration of lanreotide depot and relates those attributes to considerations and preferences of oncology nurses and their patients...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27833068/cost-benefit-analysis-of-establishing-an-inferior-vena-cava-filter-clinic
#13
Joshua D Dowell, Summit H Shah, Kyle J Cooper, Vedat Yıldız, Xueliang Pan
PURPOSE: Adverse events associated with retrievable inferior vena cava filters (IVCFs) have generated an increased interest in improving IVCF retrieval rates to improve patient safety and quality care. This study aims to demonstrate the cost-benefit of implementing an IVCF clinic to improve patient care in an institution in the United States. METHODS: An IVCF clinic was established at a single institution in September 2012 and for ten months referring physicians were contacted to facilitate retrieval when appropriate...
November 11, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27815745/a-new-perspective-on-the-value-of-minimally-invasive-colorectal-surgery-payer-provider-and-patient-benefits
#14
Deborah S Keller, Anthony J Senagore, Kathryn Fitch, Andrew Bochner, Eric M Haas
BACKGROUND: The clinical benefits of minimally invasive surgery (MIS) are proven, but overall financial benefits are not fully explored. Our goal was to evaluate the financial benefits of MIS from the payer's perspective to demonstrate the value of minimally invasive colorectal surgery. METHODS: A Truven MarketScan(®) claim-based analysis identified all 2013 elective, inpatient colectomies. Cases were stratified into open or MIS approaches based on ICD-9 procedure codes; then costs were assessed using a similar distribution across diagnosis related groups (DRGs)...
November 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27804072/long-term-prognostic-value-of-coronary-artery-calcium-scanning-coronary-computed-tomographic-angiography-and-stress-myocardial-perfusion-imaging-in-patients-with-suspected-coronary-artery-disease
#15
Carmela Nappi, Emanuele Nicolai, Stefania Daniele, Wanda Acampa, Valeria Gaudieri, Roberta Assante, Emilia Zampella, Sabrina Segreto, Massimo Imbriaco, Mario Petretta, Marco Salvatore, Alberto Cuocolo
BACKGROUND: We compared the long-term prognostic value of coronary artery calcium (CAC) scanning, coronary computed tomographic angiography (CCTA), and stress single-photon emission computed tomography myocardial perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD). METHODS AND RESULTS: A total of 164 patients were studied. CAC score was measured according to the Agatston method and patients were categorized into 3 groups (0, 1-300, and >300)...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27801641/a-systematic-review-and-economic-evaluation-of-bisphosphonates-for-the-prevention-of-fragility-fractures
#16
Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes
BACKGROUND: Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES: To evaluate the clinical effectiveness and safety of bisphosphonates [alendronic acid (Fosamax(®) and Fosamax(®) Once Weekly, Merck Sharp & Dohme Ltd), risedronic acid (Actonel(®) and Actonel Once a Week(®), Warner Chilcott UK Ltd), ibandronic acid (Bonviva(®), Roche Products Ltd) and zoledronic acid (Aclasta(®), Novartis Pharmaceuticals UK Ltd)] for the prevention of fragility fracture and to assess their cost-effectiveness at varying levels of fracture risk...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27799379/prolonged-anticoagulation-in-vte-with-direct-oral-anticoagulants-towards-an-individual-analysis-of-net-clinical-benefit
#17
EDITORIAL
Pierre-Marie Roy
No abstract text is available yet for this article.
November 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27799272/wide-variation-in-reported-rates-of-stroke-across-cohorts-of-patients-with-atrial-fibrillation
#18
Gene R Quinn, Olivia N Severdija, Yuchiao Chang, Daniel E Singer
BACKGROUND: -Oral anticoagulants (OAC) decrease ischemic stroke rates in patients with atrial fibrillation (AF) but increase the risk of bleeding. For the average AF patient, the threshold of annual ischemic stroke rate where the benefit of anticoagulation outweighs the bleeding risk (net clinical benefit) has been shown to be approximately 1-2%. Guideline recommendations for OAC in AF are based on the CHA2DS2-VASc stroke risk point scores, assuming that those scores translate to fixed stroke rates...
October 31, 2016: Circulation
https://www.readbyqxmd.com/read/27798655/combining-time-driven-activity-based-costing-with-clinical-outcome-in-cost-effectiveness-analysis-to-measure-value-in-treatment-of-depression
#19
Samir El Alaoui, Nils Lindefors
BACKGROUND: A major challenge of mental health care is to provide safe and effective treatment with limited resources. The main purpose of this study was to examine a value-based approach in clinical psychiatry when evaluating a process improvement initiative. This was accomplished by using the relatively new time driven activity based costing (TDABC) method within the more widely adopted cost-effectiveness analysis framework for economic evaluation of healthcare technologies. The objective was to evaluate the cost-effectiveness of allowing psychologists to perform post-treatment assessment previously performed by psychiatrists at an outpatient clinic treating depression using internet-based cognitive-behavioral therapy (ICBT)...
2016: PloS One
https://www.readbyqxmd.com/read/27783750/differentiating-clinical-care-from-disease-prevention-a-prerequisite-for-practicing-quaternary-prevention
#20
Charles Dalcanale Tesser, Armando Henrique Norman
This article contends that the distinction between clinical care (illness) and prevention of future disease is essential to the practice of quaternary prevention. The authors argue that the ongoing entanglement of clinical care and prevention transforms healthy into "sick" people through changes in disease classification criteria and/or cut-off points for defining high-risk states. This diverts health care resources away from those in need of care and increases the risk of iatrogenic harm in healthy people...
October 20, 2016: Cadernos de Saúde Pública
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