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https://www.readbyqxmd.com/read/29224600/evaluation-of-an-integrated-housing-and-recovery-model-for-people-with-severe-and-persistent-mental-illnesses-the-doorway-program
#1
David R Dunt, Andrew W Benoy, Andrea Phillipou, Laura L Collister, Elizabeth M Crowther, Julian Freidin, David J Castle
Objective The Doorway program is a 3-year pilot integrated housing and recovery support program aimed at people with a severe and persistent mental illness who are 'at risk' or actually homeless. Participants source and choose properties through the open rental market, with appropriate rental subsidy and brokerage support. This arrangement is highly innovative, differing from widely favoured arrangements internationally involving congregate and scattered-site housing owned or managed by the support program...
October 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29223437/outcomes-in-elderly-and-young-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-with-bivalirudin-versus-heparin-pooled-analysis-from-the-euromax-and-horizons-ami-trials
#2
Khalid Qaderdan, Gerrit-Jan A Vos, Thomas McAndrew, Philippe Gabriel Steg, Christian W Hamm, Arnoud Van't Hof, Roxana Mehran, Efthymios N Deliargyris, Debra Bernstein, Gregg W Stone, Jurriën M Ten Berg
BACKGROUND: Since older age is a strong predictor of not only bleeding but also of ischemic events, understanding the risk:benefit profile of bivalirudin in the elderly undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation (STEMI) is important. For this, we aim to compare elderly with young patients, who all underwent pPCI for STEMI and randomly received either bivalirudin or heparin. METHODS: We performed a patient-level pooled analysis (n=5800) of two large randomized trials...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29223435/atrial-fibrillation-decision-support-tool-population-perspective
#3
Mark H Eckman, Alexandru Costea, Mehran Attari, Jitender Munjal, Ruth E Wise, Carol Knochelmann, Matthew L Flaherty, Pete Baker, Robert Ireton, Brett M Harnett, Anthony C Leonard, Dylan Steen, Adam Rose, John Kues
BACKGROUND: Appropriate thromboprophylaxis for patients with atrial fibrillation or atrial flutter (AF) remains a national challenge. The recent availability of direct oral anticoagulants (DOACs) with comparable efficacy and improved safety compared with warfarin alters the balance between risk factors for stroke and benefit of anticoagulation. Our objective was to examine the impact of DOACs as an alternative to warfarin on the net benefit of oral anticoagulant therapy (OAT) in a real-world population of AF patients...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29222322/inferior-vena-cava-filter-use-and-patient-safety-legacy-or-science
#4
REVIEW
William Geerts, Rita Selby
There has been a dramatic increase in vena cava filter (VCF) use over the past 20 years in the absence of evidence that filters provide a net patient benefit or are required in most cases. This increase is largely attributable to the availability of retrievable filters and expanded indications, particularly as primary prophylaxis in patients thought to be at high risk of pulmonary embolism. Substantial variability in VCF use, unrelated to patient clinical factors, has been shown between hospitals, from region to region, and among various countries...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29213344/psychotherapy-for-major-depressive-disorder-and-generalized-anxiety-disorder-a-health-technology-assessment
#5
(no author information available yet)
Background: Major depressive disorder and generalized anxiety disorder are among the most commonly diagnosed mental illnesses in Canada; both are associated with a high societal and economic burden. Treatment for major depressive disorder and generalized anxiety disorder consists of pharmacological and psychological interventions. Three commonly used psychological interventions are cognitive behavioural therapy (CBT), interpersonal therapy, and supportive therapy. The objectives of this report were to assess the effectiveness and safety of these types of therapy for the treatment of adults with major depressive disorder and/or generalized anxiety disorder, to assess the cost-effectiveness of structured psychotherapy (CBT or interpersonal therapy), to calculate the budget impact of publicly funding structured psychotherapy, and to gain a greater understanding of the experiences of people with major depressive disorder and/or generalized anxiety disorder...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/29211800/diagnostic-test-strategies-in-children-at-increased-risk-of-inflammatory-bowel-disease-in-primary-care
#6
Gea A Holtman, Yvonne Lisman-van Leeuwen, Boudewijn J Kollen, Obbe F Norbruis, Johanna C Escher, Laurence C Walhout, Angelika Kindermann, Yolanda B de Rijke, Patrick F van Rheenen, Marjolein Y Berger
BACKGROUND: In children with symptoms suggestive of inflammatory bowel disease (IBD) who present in primary care, the optimal test strategy for identifying those who require specialist care is unclear. We evaluated the following three test strategies to determine which was optimal for referring children with suspected IBD to specialist care: 1) alarm symptoms alone, 2) alarm symptoms plus c-reactive protein, and 3) alarm symptoms plus fecal calprotectin. METHODS: A prospective cohort study was conducted, including children with chronic gastrointestinal symptoms referred to pediatric gastroenterology...
2017: PloS One
https://www.readbyqxmd.com/read/29209535/do-patients-with-reduced-or-excellent-performance-status-derive-the-same-clinical-benefit-from-novel-systemic-cancer-therapies-a-systematic-review-and-meta-analysis
#7
Sierra Cheng, Mahin Qureshi, Eleanor Pullenayegum, Adam Haynes, Kelvin Kw Chan
Background: Whether patients with excellent and reduced performance status (PS) derive different net clinical benefit from novel anticancer systemic therapies on clinical trials is unclear. Materials and methods: A systematic review was conducted of randomised controlled trials (RCTs) cited for drug approvals between 2006 and August 2015 by the Food and Drug Administration, the European Medicines Agency and Health Canada. Included studies had overall survival (OS) and/or progression-free survival (PFS) primary endpoints...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208663/haemodynamic-effects-of-umbilical-cord-milking-in-premature-sheep-during-the-neonatal-transition
#8
Douglas A Blank, Graeme R Polglase, Martin Kluckow, Andrew William Gill, Kelly J Crossley, Alison Moxham, Karyn Rodgers, Valerie Zahra, Ishmael Inocencio, Fiona Stenning, Domeic A LaRosa, Peter G Davis, Stuart B Hooper
OBJECTIVE: Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared the physiological effects of two UCM strategies with immediate umbilical cord clamping (UCC) and physiological-based cord clamping (PBCC) in preterm lambs. METHODS: At 126 days' gestational age, fetal lambs were exteriorised, intubated and instrumented to measure umbilical, pulmonary and cerebral blood flows and arterial pressures...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29205150/a-pragmatic-multicentre-randomised-controlled-trial-comparing-stapled-haemorrhoidopexy-with-traditional-excisional-surgery-for-haemorrhoidal-disease-the-ethos-study
#9
Angus Jm Watson, Jonathan Cook, Jemma Hudson, Mary Kilonzo, Jessica Wood, Hanne Bruhn, Steven Brown, Brian Buckley, Finlay Curran, David Jayne, Malcolm Loudon, Ramesh Rajagopal, Alison McDonald, John Norrie
BACKGROUND: Haemorrhoids are a benign anorectal condition and are highly prevalent in the UK population. Treatments involve clinic-based procedures and surgery. The surgical procedures available include stapled haemorrhoidopexy (SH) and traditional haemorrhoidectomy (TH), and over 25,000 operations are performed for haemorrhoids annually in the UK. The disease is therefore important both to patients and to health service commissioners. Debate remains as to which of these surgical procedures is the most clinically effective and cost-effective...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29197965/progress-of-statistical-analysis-in-biomedical-research-through-the-historical-review-of-the-development-of-the-framingham-score
#10
Aleksandra Ignjatović, Miodrag Stojanović, Zoran Milošević, Marija Anđelković Apostolović
BACKGROUND: The interest in developing risk models in medicine not only is appealing, but also associated with many obstacles in different aspects of predictive model development. Initially, the association of biomarkers or the association of more markers with the specific outcome was proven by statistical significance, but novel and demanding questions required the development of new and more complex statistical techniques. METHODS: Progress of statistical analysis in biomedical research can be observed the best through the history of the Framingham study and development of the Framingham score...
December 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29195125/effects-of-continuation-electroconvulsive-therapy-on-quality-of-life-in-elderly-depressed-patients-a-randomized-clinical-trial
#11
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Nagy A Youssef, Laryssa McCloud, Charles H Kellner
We examined whether electroconvulsive therapy (ECT) plus medications ("STABLE + PHARM" group) had superior HRQOL compared with medications alone ("PHARM" group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the "STABLE + PHARM" group versus the "PHARM" group. The overall study design was called "Prolonging Remission in Depressed Elderly" (PRIDE)...
November 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29189433/transintestinal-cholesterol-excretion-in-humans
#12
Laurens F Reeskamp, Emma C E Meessen, Albert K Groen
PURPOSE OF REVIEW: To discuss recent insights into the measurement and cellular basis of transintestinal cholesterol excretion (TICE) in humans and to explore TICE as a therapeutic target for increasing reverse cholesterol transport. RECENT FINDINGS: TICE is the net effect of cholesterol excretion by the enterocyte into the intestinal lumen and is the balance between input and output fluxes through the enterocytes. These fluxes are: cholesterol excretion into the intestinal lumen mainly via ATP-binding cassette (ABC) G5/8, cholesterol absorption from the intestine by Niemann-Pick C1 like protein 1, the uptake of plasma lipoproteins by enterocytes at the basolateral membrane, and the excretion of cholesterol in chylomicrons into the lymph...
November 16, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29187216/use-of-a-flowable-haemostat-versus-an-oxidised-regenerated-cellulose-agent-in-primary-elective-cardiac-surgery-economic-impact-from-a-uk-healthcare-perspective
#13
Mayur R Joshi, Jacqueline Latham, Gabriel Okorogheye
BACKGROUND: Flowable haemostatic agents have been shown to be superior to non-flowable agents in terms of haemostatic control and need for transfusion products in patients undergoing cardiac surgery. We investigated the economic impact of the use of a flowable haemostatic agent (Floseal) compared with non-flowable oxidised regenerated cellulose (ORC) agent in primary elective cardiac surgery from the perspective of the UK National Health Service (NHS). METHODS: A cost-consequence framework based upon clinical data from a prospective trial and an observational trial and NHS-specific actual reference costs (2016) was developed to compare the economic impact of Floseal with that of ORC...
November 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29186349/gdsctools-for-mining-pharmacogenomic-interactions-in-cancer
#14
Thomas Cokelaer, Elisabeth Chen, Francesco Iorio, Michael P Menden, Howard Lightfoot, Julio Saez-Rodriguez, Mathew J Garnett
Motivation: Large pharmacogenomic screenings integrate heterogeneous cancer genomic data sets as well as anti-cancer drug responses on thousand human cancer cell lines. Mining this data to identify new therapies for cancer sub-populations would benefit from common data structures, modular computational biology tools and user-friendly interfaces. Results: We have developed GDSCTools: a software aimed at the identification of clinically relevant genomic markers of drug response...
November 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29181884/mir-221-222-cluster-expression-improves-clinical-stratification-of-non-muscle-invasive-bladder-cancer-tat1-patients-risk-for-short-term-relapse-and-progression
#15
Foteini D Tsikrika, Margaritis Avgeris, Panagiotis K Levis, Theodoros Tokas, Konstantinos Stravodimos, Andreas Scorilas
Clinical heterogeneity of bladder cancer prognosis requires the identification of bladder tumors' molecular profile to improve the prediction value of the established and clinically used markers. In the present study, we have analyzed miR-221/222 cluster expression in bladder tumors and its clinical significance for patients' prognosis and disease outcome. The study included 387 tissue specimens. Following extraction, total RNA was polyadenylated at 3΄-end and reversed transcribed. SYBR-Green based qPCR assays were performed for the quantification of miR-221/222 expression...
November 27, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29177165/theranostics-of-neuroendocrine-tumors
#16
REVIEW
Sze Ting Lee, Harshad R Kulkarni, Aviral Singh, Richard P Baum
Somatostatin receptor positron emission tomography/computed tomography using 68Ga-labeled somatostatin analogs is the mainstay for the evaluation of receptor status in neuroendocrine tumors (NETs). This translates towards better therapy options, with increasing evidence of peptide receptor radionuclide therapy (PRRT) as the treatment of choice for advanced or progressive NETs. There are benefits in progression-free and overall survival as well as a significant improvement in clinical condition. In patients with progressive NETs, fractionated, personalized PRRT results in good therapeutic responses with no significant severe hematological and/or renal toxicity, thus improving quality of life...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29170312/15%C3%A2-a-clinical-decision-tool-for-prescribing-anti-platelet-medication-for-patients-with-suspected-acute-coronary-syndrome-pam
#17
Charles Reynard, Rick Body
BACKGROUND: The benefit of antiplatelet medication in confirmed acute coronary syndrome (ACS) is well established. In the Emergency Department (ED) diagnostic uncertainty may lead to over-treatment, with consequent risks (e.g., bleeding), or under-treatment, compromising clinical outcomes. Clinicians must subjectively balance the anticipated risks and benefits with their perceived probability of ACS in order to decide whether to prescribe these medications. We aimed to construct a clinical model to optimise and personalise recommendations for anti-platelet prescription in this context...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29153572/prognostic-value-of-quantitative-stress-perfusion-cardiac-magnetic-resonance
#18
Eva C Sammut, Adriana D M Villa, Gabriella Di Giovine, Luke Dancy, Filippo Bosio, Thomas Gibbs, Swarna Jeyabraba, Susanne Schwenke, Steven E Williams, Michael Marber, Khaled Alfakih, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
OBJECTIVES: This study sought to evaluate the prognostic usefulness of visual and quantitative perfusion cardiac magnetic resonance (CMR) ischemic burden in an unselected group of patients and to assess the validity of consensus-based ischemic burden thresholds extrapolated from nuclear studies. BACKGROUND: There are limited data on the prognostic value of assessing myocardial ischemic burden by CMR, and there are none using quantitative perfusion analysis. METHODS: Patients with suspected coronary artery disease referred for adenosine-stress perfusion CMR were included (n = 395; 70% male; age 58 ± 13 years)...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29151439/clopidogrel-or-ticagrelor-in-acute-coronary-syndrome-patients-treated-with-newer-generation-drug-eluting-stents-change-dapt
#19
Paolo Zocca, Liefke C van der Heijden, Marlies M Kok, Marije M Löwik, Marc Hartmann, Martin G Stoel, J W Louwerenburg, Frits H A F de Man, Gerard C M Linssen, Iris L Knottnerus, Carine J M Doggen, K Gert van Houwelingen, Clemens von Birgelen
AIMS: Acute coronary syndrome (ACS) guidelines have been changed, favouring more potent antiplatelet drugs. We aimed to evaluate the safety and efficacy of a ticagrelor- instead of a clopidogrel-based primary dual antiplatelet (DAPT) regimen in ACS patients treated with newer-generation drug-eluting stents (DES). METHODS AND RESULTS: CHANGE DAPT (clinicaltrials.gov: NCT03197298) assessed 2,062 consecutive real-world ACS patients, treated by percutaneous coronary intervention (PCI), the primary composite endpoint being net adverse clinical and cerebral events (NACCE: all-cause death, any myocardial infarction, stroke or major bleeding)...
November 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29147042/insecticide-treated-nets-and-malaria-prevalence-papua-new-guinea-2008-2014
#20
Manuel W Hetzel, Justin Pulford, Yangta Ura, Sharon Jamea-Maiasa, Anthony Tandrapah, Nandao Tarongka, Lina Lorry, Leanne J Robinson, Ken Lilley, Leo Makita, Peter M Siba, Ivo Mueller
Objective: To investigate changes in malaria prevalence in Papua New Guinea after the distribution of long-lasting Insecticide-treated nets, starting in 2004, and the introduction of artemisinin-based combination therapy in 2011. Methods: Two malaria surveys were conducted in 2010-2011 and 2013-2014. They included 77 and 92 randomly selected villages, respectively. In each village, all members of 30 randomly selected households gave blood samples and were assessed for malaria infection by light microscopy...
October 1, 2017: Bulletin of the World Health Organization
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