Patricia Alba, Virginia Carfora, Fabiola Feltrin, Elena Lavinia Diaconu, Luigi Sorbara, Elena Dell'Aira, Tamara Cerci, Angela Ianzano, Valentina Donati, Alessia Franco, Antonio Battisti
The increasing prevalence of pESI(like)-positive, multidrug-resistant (MDR) S. Infantis in Europe is a cause of major concern. As previously demonstrated, the pESI(like) megaplasmid is not only a carrier of antimicrobial resistant (AMR) genes (at least tet, dfr and sul genes), but also harbours several virulence and fitness genes, and toxin/antitoxin systems that enhance its persistence in the S. Infantis host. In this study, five prototype pESI(like) plasmids, of either CTX-M-1 or CTX-M-65 ESBL producing strains, were long-read sequenced using Oxford Nanopore Technology (ONT) and their complete sequences were resolved...
February 20, 2023: FEMS Microbiology Letters