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https://www.readbyqxmd.com/read/29682287/colonization-sites-in-carriers-of-esbl-producing-gram-negative-bacteria
#1
Joffrey van Prehn, Anna M Kaiser, Suzanne D van der Werff, Rosa van Mansfeld, Christina M J E Vandenbroucke-Grauls
Objective: The distribution of Extended-Spectrum Beta-Lactamase-producing Gram-negative bacteria (ESBL-GNB) colonization sites is relevant for infection control guidelines on detection and follow-up of colonization. We questioned whether it is possible to rely solely on rectal swab culture for follow-up of ESBL-GNB colonization. Methods: We retrospectively assessed ESBL-GNB colonization sites in patients in a tertiary hospital in the Netherlands. The Laboratory Information Management System was queried for all bacterial cultures obtained between January 2012 and August 2016...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29663045/infection-related-ventilator-associated-complications-in-icu-patients-colonised-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae
#2
François Barbier, Sébastien Bailly, Carole Schwebel, Laurent Papazian, Élie Azoulay, Hatem Kallel, Shidasp Siami, Laurent Argaud, Guillaume Marcotte, Benoît Misset, Jean Reignier, Michaël Darmon, Jean-Ralph Zahar, Dany Goldgran-Toledano, Étienne de Montmollin, Bertrand Souweine, Bruno Mourvillier, Jean-François Timsit
PURPOSE: To investigate the clinical significance of infection-related ventilator-associated complications (IVAC) and their impact on carbapenem consumption in mechanically ventilated (MV) patients colonised with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE). METHODS: Inception cohort study from the French prospective multicenter OUTCOMEREA database (17 ICUs, 1997-2015) including all ESBLE carriers (systematic rectal swabbing at admission then weekly and/or urinary or superficial surgical site colonisation) with MV duration > 48 h and ≥ 1 episode of IVAC after carriage documentation...
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29652969/-molecular-characterization-and-antimicrobial-susceptibility-pattern-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-as-cause-of-community-acquired-urinary-tract-infection
#3
Mario Galindo-Méndez
Background Community acquired urinary tract infections (CaUTI) caused by strains of extended-spectrum β-lactamases (ESBL) - producing Escherichia coli, mainly by strains carrying the blaCTX-M-15 gene, is a growing phenomenon worldwide. Aim To determine the antibiotic susceptibility pattern of ESBL-producing E. coli as cause of CaUTI and to identify their molecular pattern. Methods A descriptive study was performed in the city of Oaxaca, Mexico, from where 288 strains of CaUTI-producing strains of E. coli in adults with possible UTI were isolated...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29621209/vital-signs-containment-of-novel-multidrug-resistant-organisms-and-resistance-mechanisms-united-states-2006-2017
#4
Kate Russell Woodworth, Maroya Spalding Walters, Lindsey M Weiner, Jonathan Edwards, Allison C Brown, Jennifer Y Huang, Sarah Malik, Rachel B Slayton, Prabasaj Paul, Catherine Capers, Marion A Kainer, Nancy Wilde, Alicia Shugart, Garrett Mahon, Alexander J Kallen, Jean Patel, L Clifford McDonald, Arjun Srinivasan, Michael Craig, Denise M Cardo
BACKGROUND: Approaches to controlling emerging antibiotic resistance in health care settings have evolved over time. When resistance to broad-spectrum antimicrobials mediated by extended-spectrum β-lactamases (ESBLs) arose in the 1980s, targeted interventions to slow spread were not widely promoted. However, when Enterobacteriaceae with carbapenemases that confer resistance to carbapenem antibiotics emerged, directed control efforts were recommended. These distinct approaches could have resulted in differences in spread of these two pathogens...
April 6, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29600324/a-toolkit-for-the-management-of-infection-or-colonization-by-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-italy-implementation-and-outcome-of-a-european-project
#5
V Mondain, G Secondo, R Guttmann, G Ferrea, A Dusi, M Giacomini, J Courjon, C Pradier
Among European countries, prevalence rates of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are particularly high in those bordering the Mediterranean. This is the case for Italy, with 26% of Escherichia coli displaying resistance to the 3rd generation cephalosporins in 2013. An ESBL-E toolkit designed to assist clinicians in managing patients harboring ESBL-E was favorably implemented in Southern France. In a context of lack of specific Italian recommendations, its extension to an adjacent region of Italy was made possible through a cross-border EU cooperation program...
May 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29577300/prevalence-of-virulence-genes-in-extended-spectrum-%C3%AE-lactamases-esbls-producing-salmonella-in-retail-raw-chicken-in-china
#6
Jing Qiao, Walid Q Alali, Jiangshan Liu, Yaping Wang, Sheng Chen, Shenghui Cui, Baowei Yang
Extended-spectrum β-lactamases (ESBLs)-producing Salmonella is a tremendous hazard to food safety and public health. The objective of this study was to determine the prevalence of 30 virulence genes (avrA, sipA, sseC, marT, rhuM, siiE, pipA, pipD, envR, gogB, gtgA, sodC1, sseI, irsA, sopE2, spvC, rck, spvR, fhuA, msgA, pagK, srfj, stkc, fimA, lpfD, pefA, stcC, steB, stjB, and tcfA) in 156 ESBLs-producing Salmonella isolates that belonged to 21 serotypes. These isolates were recovered from retail raw chicken samples collected from 5 provinces and 2 national cities in China between 2007 and 2012...
March 25, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29561861/time-to-acquire-and-lose-carriership-of-esbl-pampc-producing-e-coli-in-humans-in-the-netherlands
#7
Peter F M Teunis, Eric G Evers, Paul D Hengeveld, Cindy M Dierikx, Cornelia C C H Wielders, Engeline van Duijkeren
A subset of the study population from a cross-sectional study of carriership of ESBL/pAmpC-producing E. coli (ESBL-E) in the general population was followed up by five successive samples over an approximate half year period, leading to six samples in 333 persons. Fecal samples were cultured and analyzed for the presence of E. coli types as characterized by MLST, and ESBL/pAmpC genes were analysed by PCR and sequencing. The study included 255 persons who had a negative first sample, to allow observations of acquiring carriership of ESBL-E...
2018: PloS One
https://www.readbyqxmd.com/read/29549056/prevalence-of-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-and-associated-factors-in-a-french-hospital
#8
Sarah Jolivet, Laetitia Vaillant, Thibaut Poncin, Isabelle Lolom, Yannick Gaudonnet, Emilie Rondinaud, Gisèle Bendjelloul, Alexandra Lomont, Jean-Christophe Lucet, Laurence Armand-Lefevre
OBJECTIVES: Our aim was to evaluate the prevalence and associated factors for carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in a healthcare facility. METHODS: We conducted a serial cross-sectional survey of ESBL-PE carriage in 2016 in a French university hospital. All patients present on the day of the survey were screened for ESBL-PE carriage. Demographic characteristics and risk factors for ESBL-PE carriage were collected...
March 13, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29330015/mother-to-child-transmission-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae
#9
Dana Danino, Rimma Melamed, Batya Sterer, Nurith Porat, Guy Hazan, Alex Gushanski, Eilon Shany, David Greenberg, Avraham Borer
BACKGROUND: Preterm infants are at high risk for extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to maternal-neonatal transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization. AIM: To identify pairs of mothers and offspring harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants...
January 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29326011/neonatal-intestinal-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-a-5-year-follow-up-study
#10
V Nordberg, K Jonsson, C G Giske, A Iversen, O Aspevall, B Jonsson, A Camporeale, M Norman, L Navér
OBJECTIVES: To analyse Klebsiella pneumoniae (KP) isolates from an outbreak of extended-spectrum β-lactamase (ESBL)-producing KP and Escherichia coli (EC) among infants admitted to neonatal intensive care units and to determine the duration of the intestinal colonization. METHODS: We performed a prospective cohort study of intestinal ESBL-KP/ESBL-EC colonized neonates after a 5-month outbreak in two neonatal intensive care units. Whole genome sequencing, multilocus sequence typing, core genome multilocus sequence typing, pulsed-field electrophoresis and PCR for blaCTX-M were performed on the first isolates...
January 8, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29284053/esbl-producing-escherichia-coli-in-swedish-gulls-a-case-of-environmental-pollution-from-humans
#11
Clara Atterby, Stefan Börjesson, Sofia Ny, Josef D Järhult, Sara Byfors, Jonas Bonnedahl
ESBL-producing bacteria are present in wildlife and the environment might serve as a resistance reservoir. Wild gulls have been described as frequent carriers of ESBL-producing E. coli strains with genotypic characteristics similar to strains found in humans. Therefore, potential dissemination of antibiotic resistance genes and bacteria between the human population and wildlife need to be further investigated. Occurrence and characterization of ESBL-producing E. coli in Swedish wild gulls were assessed and compared to isolates from humans, livestock and surface water collected in the same country and similar time-period...
2017: PloS One
https://www.readbyqxmd.com/read/29222035/carriage-of-esbl-producing-enterobacteriaceae-in-french-hospitals-the-portablse-study
#12
B Pilmis, V Cattoir, D Lecointe, A Limelette, I Grall, A Mizrahi, G Marcade, I Poilane, T Guillard, N Bourgeois Nicolaos, J-R Zahar, A Le Monnier
BACKGROUND: Currently, contact precautions are recommended for patients colonized or infected with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE). Recent studies have challenged this strategy. This study aimed to assess the rate of ESBL-PE faecal carriage among hospitalized patients according to type of hospital ward, and to identify risk factors associated with carriage. METHODS: A point prevalence study was conducted in five different types of hospital ward [medical, surgical, intensive care unit (ICU), after care and rehabilitation, and geriatric] in eight French hospitals...
March 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29215330/quantifying-hospital-acquired-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-patients-in-dutch-hospitals
#13
Marjolein F Q Kluytmans-van den Bergh, Suzan P van Mens, Manon R Haverkate, Martin C J Bootsma, Jan A J W Kluytmans, Marc J M Bonten
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014...
January 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29180984/risk-of-transmission-of-antimicrobial-resistant-escherichia-coli-from-commercial-broiler-and-free-range-retail-chicken-in-india
#14
Arif Hussain, Sabiha Shaik, Amit Ranjan, Nishant Nandanwar, Sumeet K Tiwari, Mohammad Majid, Ramani Baddam, Insaf A Qureshi, Torsten Semmler, Lothar H Wieler, Mohammad A Islam, Dipshikha Chakravortty, Niyaz Ahmed
Multidrug-resistant Escherichia coli infections are a growing public health concern. This study analyzed the possibility of contamination of commercial poultry meat (broiler and free-range) with pathogenic and or multi-resistant E. coli in retail chain poultry meat markets in India. We analyzed 168 E. coli isolates from broiler and free-range retail poultry (meat/ceca) sampled over a wide geographical area, for their antimicrobial sensitivity, phylogenetic groupings, virulence determinants, extended-spectrum-β-lactamase (ESBL) genotypes, fingerprinting by Enterobacterial Repetitive Intergenic Consensus (ERIC) PCR and genetic relatedness to human pathogenic E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29149242/long-term-carriage-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-in-the-general-population-in-the-netherlands
#15
Engeline van Duijkeren, Cornelia C H Wielders, Cindy M Dierikx, Angela H A M van Hoek, Paul Hengeveld, Christiaan Veenman, Alice Florijn, Aniek Lotterman, Lidwien A M Smit, Jaap T van Dissel, Catharina B M Maassen, Sabine C de Greeff
Background: This longitudinal study aimed to investigate (risk factors for) persistence of carriage and molecular characteristics of extended-spectrum and plasmid-encoded AmpC β-lactamase-producing (ESBL/pAmpC) Escherichia coli and Klebsiella pneumoniae (ESBL-E/K) in adults in the Dutch community. Methods: Following a cross-sectional study (ESBL-E/K prevalence, 4.5%), a subset of ESBL-E/K-positive (n = 76) and -negative (n = 249) individuals volunteered to provide 5 monthly fecal samples and questionnaires...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29116290/drug-resistance-ampc-%C3%AE-lactamase-and-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-isolated-from-fish-and-shrimp
#16
Marília Viana Albuquerque de Almeida, Ítalo Mendes Cangussú, Antonia Leonadia Siqueira de Carvalho, Izabelly Linhares Ponte Brito, Renata Albuquerque Costa
The present study aims to detect the production of extended-spectrum beta-lactamases (ESBL) by enterobacteria isolated from samples of fresh shrimp and fish obtained from the retail trade of the city of Sobral, Ceará State, Brazil. All bacterial isolates were submitted to identification and antimicrobial susceptibility testing using aminopenicillin, beta-lactamase inhibitors, carbapenem, 1st, 2nd, 3rd and 4th generation cephalosporins, and monobactam. Three types of beta-lactamases - ESBL, AmpC and KPC - were investigated...
November 6, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29111480/draft-genome-sequences-of-two-fluoroquinolone-resistant-ctx-m-15-producing-escherichia-coli-st90-st23-complex-isolated-from-a-calf-and-a-dairy-cow-in-south-america
#17
Luciana Sartori, Miriam R Fernandes, Susan Ienne, Tiago A de Souza, Lilian Gregory, Louise Cerdeira, Nilton Lincopan
OBJECTIVES: Farm animals have been recognised as important carriers and reservoirs of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The aim of this study was to report the draft genome sequences of two multidrug-resistant (MDR) CTX-M-15-producing E. coli strains (47VL and 13B) isolated from different bovine hosts (a calf and a dairy cow), housed separately in a commercial dairy farm in Brazil. METHODS: Total genomic DNA of the E. coli isolates was sequenced using an Illumina MiSeq paired-end 300-bp sequencing platform...
December 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29102989/universal-or-targeted-approach-to-prevent-the-transmission-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-intensive-care-units-a-cost-effectiveness-analysis
#18
Lidia Kardaś-Słoma, Jean-Christophe Lucet, Anne Perozziello, Camille Pelat, Gabriel Birgand, Etienne Ruppé, Pierre-Yves Boëlle, Antoine Andremont, Yazdan Yazdanpanah
OBJECTIVE: Several control strategies have been used to limit the transmission of multidrug-resistant organisms in hospitals. However, their implementation is expensive and effectiveness of interventions for the control of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) spread is controversial. Here, we aim to assess the cost-effectiveness of hospital-based strategies to prevent ESBL-PE transmission and infections. DESIGN: Cost-effectiveness analysis based on dynamic, stochastic transmission model over a 1-year time horizon...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28992133/intestinal-carriage-of-third-generation-cephalosporin-resistant-and-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-healthy-us-children
#19
Shamim Islam, Rangaraj Selvarangan, Neena Kanwar, Rendie McHenry, James D Chappell, Natasha Halasa, Mary E Wikswo, Daniel C Payne, Parvin H Azimi, L Clifford McDonald, Oscar G Gomez-Duarte
Background: The epidemiology of antibiotic-resistant Enterobacteriaceae intestinal carriage in healthy US children has not been well characterized. Methods: Children between 14 days and 14 years of age were enrolled during well-child visits in Oakland, California, Kansas City, Kansas, and Nashville, Tennessee, between December 2013 and March 2015. Data on recent antibiotic use by the child and travel and hospitalization history of all members of each child's household were obtained with a risk-factor survey...
June 15, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28962997/cessation-of-screening-for-intestinal-carriage-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-a-low-endemicity-intensive-care-unit-with-universal-contact-precautions
#20
W Jalalzaï, M Boutrot, J Guinard, A Guigon, L Bret, D-M Poisson, T Boulain, F Barbier
OBJECTIVES: The usefulness of screening for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) with active surveillance cultures (ASC) remains equivocal in low-endemicity intensive care units (ICUs). Our primary objective was to appraise the impact of ceasing ASC on the incidence of ICU-acquired ESBL-E infections in an ICU with universal contact precautions (CP). Patient outcomes and carbapenem consumption were also investigated. METHODS: A single-ICU, retrospective, uncontrolled before-and-after study including all patients admitted for ≥3 days during two consecutive 1-year periods with and without ASC...
April 2018: Clinical Microbiology and Infection
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