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Esbl carrier

Maris S Arcilla, Jarne M van Hattem, Manon R Haverkate, Martin C J Bootsma, Perry J J van Genderen, Abraham Goorhuis, Martin P Grobusch, Astrid M Oude Lashof, Nicky Molhoek, Constance Schultsz, Ellen E Stobberingh, Henri A Verbrugh, Menno D de Jong, Damian C Melles, John Penders
BACKGROUND: International travel contributes to the dissemination of antimicrobial resistance. We investigated the acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) during international travel, with a focus on predictive factors for acquisition, duration of colonisation, and probability of onward transmission. METHODS: Within the prospective, multicentre COMBAT study, 2001 Dutch travellers and 215 non-travelling household members were enrolled...
October 14, 2016: Lancet Infectious Diseases
Soumaya Moustafa Hijazi, Mohamad Anwar Fawzi, Faten Moustafa Ali, Khaled Hussein Abd El Galil
INTRODUCTION: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) infections are a growing threat to children, and the treatment of these infections becomes more and more challenging. A huge reservoir for ESBLs in the community is the fecal flora of children. This study investigates the rectal colonization, associated risk factors, antimicrobial susceptibility, and molecular characterization of ESBL-PE in Lebanese community infants. METHODOLOGY: A total of 117 rectal swabs were taken from healthy infants between 1 and 12 months of age...
September 30, 2016: Journal of Infection in Developing Countries
M J M Bonten
Antibiotic resistance is considered a major threat to healthcare. The Dutch government recently announced additional measures to contain this threat, one of these being the creation of regional care networks dedicated to control antibiotic resistance. Among the anticipated activities of these networks is quantifying the prevalence of antibiotic resistance in nursing homes, through regular point-prevalence surveillance studies. There is a broadly felt belief that nursing homes might be a 'mer à boire' of antibiotic resistance...
2016: Nederlands Tijdschrift Voor Geneeskunde
M Harries, J Dreesman, S Rettenbacher-Riefler, E Mertens
Children may be at higher risk for carriage of antimicrobial-resistant bacteria because of higher usage of antimicrobials. They also have higher rates of Shiga toxin-producing Escherichia coli (STEC) infections than other population groups. Some infections, particularly in children, are asymptomatic, but still lead to the excretion of large numbers of bacteria and viruses that may cause clinical disease in other individuals. That is one reason why, in Lower Saxony as in other German federal states - asymptomatic carriers of STEC are excluded from nurseries and schools until three consecutive stool samples test negative in order to prevent secondary cases...
September 9, 2016: Epidemiology and Infection
Victoire de Lastours, Dorothée Chopin, Hervé Jacquier, Camille d'Humières, Charles Burdet, Françoise Chau, Erick Denamur, Bruno Fantin
Four-hundred-fifty-eight patients were prospectively included at hospital admission and screened for ESBL-E. coli carriage in 2007 and 2010-12. A 4-fold increase in ESBL carriage (3% to 12%), a 5-fold increase in numbers of community patients among ESBL-carriers and a higher number of multiple ESBL-strains was found in 2010-12. ESBL-E. coli represented the dominant E. coli strain (relative abundance>50%) in 10/32 (31%) ESBL-carriers. This represents a major threat in terms of infectious risk and dissemination...
September 6, 2016: Antimicrobial Agents and Chemotherapy
Kassu Desta, Yimtubezinash Woldeamanuel, Aklilu Azazh, Halima Mohammod, Dawit Desalegn, Damte Shimelis, Dereje Gulilat, Biruk Lamisso, Eyasu Makonnen, Alemayehu Worku, Kerstin Mannerqvist, Johan Struwe, Olov Aspevall, Eleni Aklillu
We investigated the gastrointestinal colonization rate and antibiotic resistance patterns of Extended-Spectrum Beta-Lactamase (ESBL)- producing Escherichia coli and Klebsiella pneumoniae in hospitalized patients admitted at Ethiopia's largest tertiary hospital. Fecal samples/swabs from 267 patients were cultured on chrome agar. ESBL. Bacterial species identification, verification of ESBL production and antibiotic susceptibility testing were done using Vitek 2 system (bioMérieux, France). Phenotype characterization of ESBL-E...
2016: PloS One
Falzon A Parascandalo, P Zarb, E Tartari, D Lacej, S Bitincka, O Manastirliu, D Nika, M A Borg
BACKGROUND: Antimicrobial resistance has been recognised as a serious global Public Health problem. Prevalence of Multiple-Drug-Resistant (MDR) organism carriage in Albania is largely unknown since no national surveillance system is in place and few publications are accessible in the literature. METHODS: A 1-day point-prevalence-survey (PPS) screening for nasal methicillin-resistant Staphylococcus aureus (MRSA) and rectal MDR Gram-negative carriage was carried out at the high-dependency wards in the country's only tertiary care hospital, in Tirana...
2016: Antimicrobial Resistance and Infection Control
Abdoul-Salam Ouedraogo, Mahamadou Sanou, Aimée Kissou, Soufiane Sanou, Hermann Solaré, Firmin Kaboré, Armel Poda, Salim Aberkane, Nicolas Bouzinbi, Idrissa Sano, Boubacar Nacro, Lassana Sangaré, Christian Carrière, Dominique Decré, Rasmata Ouégraogo, Hélène Jean-Pierre, Sylvain Godreuil
BACKGROUND: Nothing is known about the epidemiology and resistance mechanisms of extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) in Burkina Faso. The objective of this study was to determine ESBL-PE prevalence and to characterize ESBL genes in Burkina Faso. METHODS: During 2 months (June-July 2014), 1602 clinical samples were sent for bacteriologic investigations to the microbiology laboratories of the tree main hospitals of Burkina Faso. Isolates were identified by mass spectrometry using a matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) BioTyper...
2016: BMC Infectious Diseases
Oskar Ljungquist, Ditte Ljungquist, Mattias Myrenås, Cecilia Rydén, Maria Finn, Björn Bengtsson
BACKGROUND: Extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESCRE) are an increasing healthcare problem in both human and veterinary medicine. The spread of ESCRE is complex with multiple reservoirs and different transmission routes. The aim of this study was to investigate if ESCRE carriage in dogs is more prevalent in households with a known human carrier, compared to households where humans are known to be negative for ESCRE. Identical ESCRE strains in humans and dogs of the same household would suggest a possible spread between humans and dogs...
2016: Infection Ecology & Epidemiology
Charles Dariane, Alexandre Amin, Olivier Lortholary, Alexandre Lalli, Constance Michel, Thomas Le Guilchet, Jean-Marc Treluyer, Thao Nguyen-Khoa, Claudia De Toma, Saïk Urien, Arnaud Méjean, Philippe Bourget, Marc-Olivier Timsit
The incidence of urinary tract infections caused by extended-spectrum β-lactamase (ESBL)-producing pathogens is increasing. These infections are associated with a long hospital stay in patients undergoing urological procedures. We aimed to demonstrate that significant intraprostatic diffusion of ertapenem is achieved after a single preoperative administration. A referred sample of 19 patients requiring surgery for benign prostatic hyperplasia was prospectively included. Patients received a 1 g intravenous (i...
August 2016: International Journal of Antimicrobial Agents
A Hamprecht, A M Rohde, M Behnke, S Feihl, P Gastmeier, F Gebhardt, W V Kern, J K Knobloch, A Mischnik, B Obermann, C Querbach, S Peter, C Schneider, W Schröder, F Schwab, E Tacconelli, M Wiese-Posselt, T Wille, M Willmann, H Seifert, J Zweigner
OBJECTIVES: The objectives of this study were to prospectively assess the rectal carriage rate of third-generation cephalosporin-resistant Enterobacteriaceae (3GCREB) in non-ICU patients on hospital admission and to investigate resistance mechanisms and risk factors for carriage. METHODS: Adult patients were screened for 3GCREB carriage at six German tertiary care hospitals in 2014 using rectal swabs or stool samples. 3GCREB isolates were characterized by phenotypic and molecular methods...
October 2016: Journal of Antimicrobial Chemotherapy
Haggai Bar-Yoseph, Khetam Hussein, Eyal Braun, Mical Paul
BACKGROUND: ESBL-producing Enterobacteriaceae and carbapenem-resistant Enterobacteriaceae (CRE) are rapidly spreading worldwide. Their natural reservoir is intestinal. METHODS: We carried out a systematic review and meta-analysis to estimate CRE and ESBL carriage duration and to evaluate the effect of decolonization therapy. We included cohort and comparative studies examining the natural history of CRE/ESBL colonization, examining rates of carriage following decolonization or comparing decolonization and no decolonization conducted in the healthcare setting or in the community...
October 2016: Journal of Antimicrobial Chemotherapy
Linda Verhoef, Monique Roukens, Sabine de Greeff, Nico Meessen, Stephanie Natsch, Ellen Stobberingh
OBJECTIVES: The objective of this study was to assess carriage of antimicrobial-resistant commensal microorganisms, i.e. Escherichia coli and Staphylococcus aureus, and its predictors in long-term-care facilities (LTCFs). METHODS: Nasal swabs and/or urine or incontinence samples were collected from participating residents in 111 LTCFs and tested for the presence of S. aureus and/or E. coli, respectively. Antimicrobial resistance to eight antimicrobials was linked to antimicrobial usage in the year preceding sampling and to LTCF characteristics...
September 2016: Journal of Antimicrobial Chemotherapy
Abdoul-Salam Ouédraogo, Soufiane Sanou, Aimée Kissou, Armel Poda, Salim Aberkane, Nicolas Bouzinbi, Boubacar Nacro, Rasmata Ouédraogo, Philippe Van De Perre, Christian Carriere, Dominique Decré, Hélène Jean-Pierre, Sylvain Godreuil
Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) have been described worldwide, but few reports focused on Burkina Faso. To assess the prevalence of digestive carriage of such bacteria in the community and in the hospital, 214 fecal samples, 101 from healthy volunteers and 113 from hospitalized patients without digestive pathology, were collected in Bobo Dioulasso, Burkina Faso economic capital, during July and August 2014. Stool samples were screened using ESBL agar plates. Strains were identified by mass spectrometry using the Biotyper MALDI-TOF...
April 19, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Yan He, Jun Tian, Xintao Chen, Weiguang Sun, Hucheng Zhu, Qin Li, Liang Lei, Guangmin Yao, Yongbo Xue, Jianping Wang, Hua Li, Yonghui Zhang
Four naphtho-γ-pyrones (fonsecinones A and C and aurasperones A and E) were identified as potential antibacterial agents against Escherichia coli, extended-spectrum β-lactamase (ESBL)-producing E. coli, Pseudomonas aeruginosa, Enterococcus faecalis, and methicillin-resistant Staphylococcus aureus (MRSA) in an in vitro antibacterial screen of 218 fungal metabolites. Fonsecinone A (2) exhibited the most potent antibacterial activity, with minimum inhibitory concentrations (MICs) of 4.26, 17.04, and 4.26 μg/mL against ESBL-producing E...
2016: Scientific Reports
Khursheed Ali, Sourabh Dwivedi, Ameer Azam, Quaiser Saquib, Mansour S Al-Said, Abdulaziz A Alkhedhairy, Javed Musarrat
ZnO nanoparticles (ZnONPs) were synthesised through a simple and efficient biogenic synthesis approach, exploiting the reducing and capping potential of Aloe barbadensis Miller (A. vera) leaf extract (ALE). ALE-capped ZnO nanoparticles (ALE-ZnONPs) were characterized using UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM) analyses. XRD analysis provided the average size of ZnONPs as 15 nm...
June 15, 2016: Journal of Colloid and Interface Science
Emilio Maseda, Patricia Salgado, Víctor Anillo, Guillermo Ruiz-Carrascoso, Rosa Gómez-Gil, Carmen Martín-Funke, Maria-Jose Gimenez, Juan-José Granizo, Lorenzo Aguilar, Fernando Gilsanz
INTRODUCTION: In 2011, a hospital-wide outbreak of OXA-48 producing Klebsiella pneumoniae occurred in our hospital, an epidemiological setting of high ESBL-producing K. pneumoniae rates. This study identifies risk factors for colonization with carbapenemase-producing enterobacteria (CPE) at Surgical Intensive Care Unit (SICU) admission. METHODS: A 2-year retrospective study was performed in all patients admitted to the SICU that following routine had a rectal swab collected upon admission...
March 22, 2016: Enfermedades Infecciosas y Microbiología Clínica
H Mezhoud, I Chantziaras, M Iguer-Ouada, N Moula, A Garmyn, A Martel, A Touati, A Smet, F Haesebrouck, F Boyen
Antimicrobial resistance is recognized as one of the most important global health challenges. Broilers are an important reservoir of antimicrobial resistant bacteria in general and, more particularly, extended-spectrum β-lactamases (ESBL)/AmpC-producing Enterobacteriaceae. Since contamination of 1-day-old chicks is a potential risk factor for the introduction of antimicrobial resistant Enterobacteriaceae in the broiler production chain, the presence of antimicrobial resistant coliform bacteria in broiler hatching eggs was explored in the present study...
August 2016: Avian Pathology: Journal of the W.V.P.A
Silvia Angeletti, Giancarlo Ceccarelli, Serena Vita, Giordano Dicuonzo, Maurizio Lopalco, Etleva Dedej, Aletheia Blasi, Francesca Antonelli, Alessia Conti, Marina De Cesaris, Francesca Farchi, Alessandra Lo Presti, Massimo Ciccozzi
BACKGROUND: Three years of civil war in Syria have caused death and increase of communicable diseases. The suffering population has been forced to migrate creating a fertile condition for epidemic spread of infection within the refugee camps. METHODS: Forty-eight Syrian migrants, upon their arrival in Italy, were accommodated at the asylum seekers centre of Castelnuovo di Porto. They received a physical examination and were subjected to microbiological surveillance by blood, rectal, pharyngeal and nasal swabs collection and delivering to the Clinical Pathology and Microbiology Laboratory of the University Campus Bio-Medico of Rome...
March 2016: Travel Medicine and Infectious Disease
Ming-Fang Cheng, Wan-Ling Chen, I-Fei Huang, Jung-Ren Chen, Yee-Hsuan Chiou, Yao-Shen Chen, Susan Shin-Jung Lee, Wan-Yu Hung, Chih-Hsin Hung, Jiun-Ling Wang
BACKGROUND: Community-acquired urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli is an emerging problem. Compared with urban infants, rural infants may encounter different distributions of community-acquired resistant strains and various barriers to efficient management. METHODS: A retrospective survey and comparison was conducted for infants with UTI caused by ESBL-producing E. coli admitted to an urban hospital (n = 111) and a rural hospital (n = 48) in southern Taiwan from 2009 to 2012...
August 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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