keyword
https://read.qxmd.com/read/38532579/normobaric-hyperoxia-alleviates-complement-c3-mediated-synaptic-pruning-and-brain-injury-after-intracerebral-hemorrhage
#1
JOURNAL ARTICLE
Moxin Wu, Kai Chen, Yasong Zhao, Min Jiang, Bing Bao, Wenmin Yu, Zhiying Chen, Xiaoping Yin
BACKGROUND: Intracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the complement cascade exacerbates brain injury after ICH. As the most abundant component of the complement system, complement component 3 (C3) plays essential roles in all three complement pathways. However, the effects of C3 on neurological impairment and brain injury in ICH patients and the related mechanism have not been fully elucidated. Normobaric hyperoxia (NBO) is regarded as a treatment for ICH patients, and recent clinical studies also have confirmed the neuroprotective role of NBO against acute ICH-mediated brain damage, but the underlying mechanism still remains elusive...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38524828/the-effect-of-normobaric-hypoxia-on-acute-exercise-induced-changes-in-blood-sphingoid-base-1-phosphates-metabolism-in-cyclists
#2
JOURNAL ARTICLE
Katarzyna Hodun, Miłosz Czuba, Kamila Płoszczyca, Jerzy Sadowski, Józef Langfort, Adrian Chabowski, Marcin Baranowski
Extracellular sphingosine-1-phosphate (S1P) emerged as an important regulator of muscle function. We previously found that plasma S1P concentration is elevated in response to acute exercise and training. Interestingly, hypoxia, which is commonly utilized in training programs, induces a similar effect. Therefore, the aim of the current study was to determine the effect of normobaric hypoxia on exercise-induced changes in blood sphingolipid metabolism. Fifteen male competitive cyclists performed a graded cycling exercise until exhaustion (GE) and a simulated 30 km individual time trial (TT) in either normoxic or hypoxic (FiO2 = 16...
March 2024: Biology of Sport
https://read.qxmd.com/read/38496896/three-sessions-of-repeated-sprint-training-in-normobaric-hypoxia-improves-sprinting-performance
#3
JOURNAL ARTICLE
Abdulkadir Birol, Dicle Aras, Cengiz Akalan, Monira I Aldhahi, Mehmet Gülü
The objective of the present study was to evaluate the impacts of three-session repeated sprint training conducted in normobaric hypoxia with 48-h intervals on sprint performance, arterial oxygen saturation (SpO2 ), and rating of perceived exertion (RPE) scores. A total of 27 moderately trained male university students voluntarily took part in this study. In this single-blind placebo-controlled study, subjects were assigned into normobaric hypoxia (FiO2: 13.6%; HYP), normobaric normoxia (FiO2: 20.9%; PLA), and control group (CON)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38488104/validation-of-air-storage-system-for-hypoxia-exposure-during-exercise
#4
JOURNAL ARTICLE
Matheus S Norberto, João Victor G Torini, Matheus S Firmino, Marcelo Papoti
Norberto, Matheus S., João Victor G. Torini, Matheus S. Firmino, and Marcelo Papoti. Validation of air storage system for hypoxia exposure during exercise. High Alt Med Biol . 00:000-000, 2024.-Considering the importance of optimizing normobaric hypoxia exposure (i.e., higher delivery capacity), the current study aims to validate a hypoxic air storage system. The study has a cross-over, one-blind randomized design. The air storage is composed of a piping system that directs hypoxic air from a hypoxia generator into nylon bags...
March 15, 2024: High Altitude Medicine & Biology
https://read.qxmd.com/read/38481962/a-novel-hypobaric-perfusion-method-to-remove-microthrombi-in-kidney-grafts-with-prolonged-circulatory-arrest-a-pilot-study-on-a-porcine-model
#5
JOURNAL ARTICLE
Yoshitaka Kinoshita, Satomi Iwai, Shinji Torai, Kanta Kurauchi, Takashi Yokoo, Haruki Kume, Rene Tolba, Eiji Kobayashi
BACKGROUND: Intragraft microthrombi prevent complete organ perfusion, thereby compromising the viability maintained by preservation solutions or machine perfusion. Herein, we developed and evaluated a hypobaric perfusion method for flushing microthrombi from kidney grafts with prolonged circulatory arrest in a porcine model. METHODS: Porcine renal grafts with 1-h warm ischemia were flushed with heparin-containing perfusate in a normobaric environment (control group) or a hypobaric environment of -20 to -30 mm Hg (hypobaric perfusion group) for 10 min using a gravity drip from a 1-m height...
April 2024: Transplantation Direct
https://read.qxmd.com/read/38477221/intermittent-hypoxia-preconditioning-can-attenuate-acute-hypoxic-injury-after-a-sustained-normobaric-hypoxic-exposure-a-randomized-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Yuan Wang, Qihan Zhang, Qingfeng Ma, Qing Wang, Dan Huang, Xunming Ji
BACKGROUND: Intermittent hypoxia (IH) is emerging as a cost-effective nonpharmacological method for vital organ protection. We aimed to assess the effects of a short-term moderate intermittent hypoxia preconditioning protocol (four cycles of 13% hypoxia lasting for 10 min with 5-min normoxia intervals) on acute hypoxic injury induced by sustained hypoxic exposure (oxygen concentration of 11.8% for 6 h). METHODS: One hundred healthy volunteers were recruited and randomized to the IH group and the control group to receive IH or sham-IH preconditioning for 5 days, respectively, and then were sent to a hypoxic chamber for simulated acute high-altitude exposure (4500 m)...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38454449/cd73-adenosine-axis-exerts-cardioprotection-against-hypobaric-hypoxia-induced-metabolic-shift-and-myocarditis-in-a-sex-dependent-manner
#7
JOURNAL ARTICLE
Marie Louise Ndzie Noah, Richard Mprah, Prosperl Ivette Wowui, Adebayo Oluwafemi Adekunle, Joseph Adu-Amankwaah, Rubin Tan, Zheng Gong, Tao Li, Lu Fu, Jeremiah Ong'achwa Machuki, Shijie Zhang, Hong Sun
BACKGROUND: Clinical and experimental studies have shown that the myocardial inflammatory response during pathological events varies between males and females. However, the cellular and molecular mechanisms of these sex differences remain elusive. CD73/adenosine axis has been linked to anti-inflammatory responses, but its sex-specific cardioprotective role is unclear. The present study aimed to investigate whether the CD73/adenosine axis elicits sex-dependent cardioprotection during metabolic changes and myocarditis induced by hypobaric hypoxia...
March 7, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38446192/hypoxia-matters-comparison-of-external-and-internal-training-load-markers-during-an-8-week-resistance-training-program-in-normoxia-normobaric-hypoxia-and-hypobaric-hypoxia
#8
JOURNAL ARTICLE
Lara Rodríguez-Zamora, Cristina Benavente, Irene Petrer, Paulino Padial, Rafa Timón, Javier Arguelles, Belén Feriche
PURPOSE: To compare external and internal training load markers during resistance training (RT ) in normoxia (N), intermittent hypobaric hypoxia (HH), and intermittent normobaric hypoxia (NH). METHODS: Thirty-three volunteers were assigned an 8-week RT program in either N (690 m, n = 10), HH (2320 m, n = 10), or NH (inspired fraction of oxygen = 15.9%; ~ 2320 m, n = 13). The RT program (3x/week) consisted of six exercises, with three sets of six to 12 repetitions at ~ 70% of one repetition maximum (1RM) with the first session of each week used for analysis...
March 6, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/38433766/carboxyhemoglobin-half-life-toxicokinetic-profiles-during-and-after-normobaric-oxygen-therapy-on-a-swine-model
#9
JOURNAL ARTICLE
N Delvau, L Elens, A Penaloza, G Liistro, F Thys, P M Roy, P Gianello, P Hantson
Investigations on acute carbon monoxide (CO) poisoning struggle to highlight a relevant discriminant criterion related to CO poisoning severity for predicting complications, such as delayed neurological syndromes. In this context, it remains difficult to demonstrate the superiority of one method of oxygen (O2 ) administration over others or to identify the optimal duration of normobaric 100% oxygen (NBO) treatment. Myoglobin, as hemoglobin, are a potential binding site for CO, which could be a source of extravascular CO storage that impacts the severity of CO poisoning...
June 2024: Toxicology Reports
https://read.qxmd.com/read/38416753/comparison-of-hypoxia-and-hyperoxia-induced-alteration-of-epigene-expression-pattern-in-lungs-of-pleurodeles-waltl-and-mus-musculus
#10
JOURNAL ARTICLE
Md Mahmudul Hasan, Reiko Sekiya, Xu Zhang, Mhd Yousuf Yassouf, Tao-Sheng Li
Epigenetics is an emerging field of research because of its involvement in susceptibility to diseases and aging. Hypoxia and hyperoxia are known to be involved widely in various pathophysiologies. Here, we compared the differential epigene expression pattern between Pleurodeles waltl and Mus musculus (commonly known as Iberian ribbed newt and mouse, respectively) exposed to hypoxia and hyperoxia. Adult healthy newts and mice were exposed to normobaric hypoxia (8% O2) and hyperoxia (80% O2) for 2 hours. We collected the lungs and analyzed the expression of hypoxia-inducible factor 1 alpha (Hif1α) and several key epigenes from DNA methyltransferase (DNMT) family, histone deacetylase (HDAC) family, and methyl-CpG binding domain (MBD) family...
2024: PloS One
https://read.qxmd.com/read/38406153/neurological-sequelae-after-acute-carbon-monoxide-poisoning
#11
Bhushan Sudhakar Wankhade, Wasim Shabbir Shaikh, Zeyad Faoor Alrais, Adel Elsaid ElKhouly, Ammar Ali Salman
Carbon monoxide poisoning (COP) is a common cause of death due to poisoning. After COP, a significant number of patients may develop a distinct type of neurological dysfunction called delayed neurological sequel (DNS). Recently, we came across a disaster of COP cases after a fire in a shared accommodation. The hostel was overcrowded and had a faulty air-conditioning/exhaust system. A total of five patients with loss of consciousness and shock were brought to us. They were diagnosed with acute COP based on their history of exposure to carbon monoxide (CO) and elevated carboxyhemoglobin levels in blood gas measurements...
January 2024: Curēus
https://read.qxmd.com/read/38399634/correction-kujawski-et-al-autonomic-and-cognitive-function-response-to-normobaric-hyperoxia-exposure-in-healthy-subjects-preliminary-study-medicina-2020-56-172
#12
Sławomir Kujawski, Joanna Słomko, Karl J Morten, Modra Murovska, Katarzyna Buszko, Julia L Newton, Paweł Zalewski
There was an error in the original publication [...].
February 1, 2024: Medicina
https://read.qxmd.com/read/38397071/pulsed-hyperoxia-acts-on-plasmatic-advanced-glycation-end-products-and-advanced-oxidation-protein-products-and-modulates-mitochondrial-biogenesis-in-human-peripheral-blood-mononuclear-cells-a-pilot-study-on-the-normobaric-oxygen-paradox
#13
JOURNAL ARTICLE
Costantino Balestra, Sara Baldelli, Fabio Virgili, Michele Salvagno, Simona Mrakic-Sposta, Deborah Fratantonio
The "normobaric oxygen paradox" (NOP) describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox-sensitive transcription factors. We have previously characterized the time trend of oxygen-sensitive transcription factors in human PBMCs, in which the return to normoxia after 30% oxygen is sensed as a hypoxic trigger, characterized by hypoxia-induced factor (HIF-1) activation. On the contrary, 100% and 140% oxygen induce a shift toward an oxidative stress response, characterized by NRF2 and NF-kB activation in the first 24 h post exposure...
February 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394255/arterial-oxygen-desaturation-during-moderate-hypoxia-hinders-sensorimotor-performance
#14
JOURNAL ARTICLE
Jason M Keeler, Jennifer B Listman, M Jo Hite, David J Heeger, Erica Tourula, Nicholas L Port, Zachary J Schlader
INTRODUCTION: Moderate hypoxia may impact cognitive and sensorimotor performance prior to self-recognized impairments. Therefore, rapid and objective assessment tools to identify people at risk of impaired function during moderate hypoxia is needed. PURPOSE: Test the hypothesis that reductions in arterial oxygen saturation during moderate normobaric hypoxia (FiO2 = 14%) decreases gamified sensorimotor performance as measured by alterations of motor acuity. METHODS: Following three consecutive days of practice, thirty healthy adults (25 ± 5 y, 10 females) completed three bouts of the tablet-based gamified assessment (Statespace Labs, Inc...
2024: PloS One
https://read.qxmd.com/read/38392086/identifying-the-causes-of-unexplained-dyspnea-at-high-altitude-using-normobaric-hypoxia-with-echocardiography
#15
JOURNAL ARTICLE
Jan Stepanek, Juan M Farina, Ahmed K Mahmoud, Chieh-Ju Chao, Said Alsidawi, Chadi Ayoub, Timothy Barry, Milagros Pereyra, Isabel G Scalia, Mohammed Tiseer Abbas, Rachel E Wraith, Lisa S Brown, Michael S Radavich, Pamela J Curtisi, Patricia C Hartzendorf, Elizabeth M Lasota, Kyley N Umetsu, Jill M Peterson, Kristin E Karlson, Karen Breznak, David F Fortuin, Steven J Lester, Reza Arsanjani
Exposure to high altitude results in hypobaric hypoxia, leading to physiological changes in the cardiovascular system that may result in limiting symptoms, including dyspnea, fatigue, and exercise intolerance. However, it is still unclear why some patients are more susceptible to high-altitude symptoms than others. Hypoxic simulation testing (HST) simulates changes in physiology that occur at a specific altitude by asking the patients to breathe a mixture of gases with decreased oxygen content. This study aimed to determine whether the use of transthoracic echocardiography (TTE) during HST can detect the rise in right-sided pressures and the impact of hypoxia on right ventricle (RV) hemodynamics and right to left shunts, thus revealing the underlying causes of high-altitude signs and symptoms...
January 31, 2024: Journal of Imaging
https://read.qxmd.com/read/38380151/influence-of-short-term-hypoxic-exposure-on-spatial-learning-and-memory-function-and-brain-derived-neurotrophic-factor-in-rats-a-practical-implication-to-human-s-lost-way
#16
JOURNAL ARTICLE
Masataka Kiuchi, Tadashi Uno, Tatsuya Hasegawa, Katsuhiro Koyama, Masahiro Horiuchi
The present study aimed to investigate the effects of a short period of normobaric hypoxic exposure on spatial learning and memory, and brain-derived neurotrophic factor (BDNF) levels in the rat hippocampus. Hypoxic conditions were set at 12.5% O2 . We compared all variables between normoxic trials (Norm), after 24 h (Hypo-24 h), and after 72 h of hypoxic exposure (Hypo-72 h). Spatial learning and memory were evaluated by using a water-finding task in an open field. Time to find water drinking fountains was significantly extended in Hypo 24 h (36...
2024: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/38357500/impact-of-systemic-hypoxia-and-blood-flow-restriction-on-mechanical-cardiorespiratory-and-neuromuscular-responses-to-a-multiple-set-repeated-sprint-exercise
#17
JOURNAL ARTICLE
Robert Solsona, Roméo Dériaz, Simon Albert, Maxime Chamoux, Jaume Lloria-Varella, Fabio Borrani, Anthony M J Sanchez
Introduction: Repeated sprint cycling exercises (RSE) performed under systemic normobaric hypoxia (HYP) or with blood flow restriction (BFR) are of growing interest. To the best of our knowledge, there is no stringent consensus on the cardiorespiratory and neuromuscular responses between systemic HYP and BFR during RSE. Thus, this study assessed cardiorespiratory and neuromuscular responses to multiple sets of RSE under HYP or with BFR. Methods: According to a crossover design, fifteen men completed RSE (three sets of five 10-s sprints with 20 s of recovery) in normoxia (NOR), HYP, and with bilaterally-cuffed BFR at 45% of resting arterial occlusive pressure during sets in NOR...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38341020/hyperbaric-oxygen-preconditioning-normalizes-scrotal-temperature-sperm-quality-testicular-structure-and-erectile-function-in-adult-male-rats-subjected-to-exertional-heat-injury
#18
JOURNAL ARTICLE
Kun-Lin Hsieh, Tzong-Bor Sun, Kuan-Hua Huang, Cheng-Hsien Lin, Ling-Yu Tang, Chien-Liang Liu, Chien-Ming Chao, Ching-Ping Chang
Testicular hyperthermia has been noted in men who work in high ambient temperatures. Scrotal temperatures above the normal range caused germ cell loss in the testes and resulted in male subfertility. In adult male rats, exercising at a higher environmental temperature (36 °C with relative humidity of 50%, 52 min) caused exertional heat stroke (EHS) characterized by scrotal hyperthermia, impaired sperm quality, dysmorphology in testes, prostates and bladders, and erectile dysfunction. Here, we aim to ascertain whether hyperbaric oxygen preconditioning (HBOP: 100% O2 at 2...
February 9, 2024: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/38333911/chronic-hypoxia-impairs-skeletal-muscle-repair-via-hif-2%C3%AE-stabilization
#19
JOURNAL ARTICLE
Amelia Yin, Wenyan Fu, Anthony Elengickal, Joonhee Kim, Yang Liu, Anne Bigot, Kamal Mamchaoui, Jarrod A Call, Hang Yin
BACKGROUND: Chronic hypoxia and skeletal muscle atrophy commonly coexist in patients with COPD and CHF, yet the underlying physio-pathological mechanisms remain elusive. Muscle regeneration, driven by muscle stem cells (MuSCs), holds therapeutic potential for mitigating muscle atrophy. This study endeavours to investigate the influence of chronic hypoxia on muscle regeneration, unravel key molecular mechanisms, and explore potential therapeutic interventions. METHODS: Experimental mice were exposed to prolonged normobaric hypoxic air (15% pO2 , 1 atm, 2 weeks) to establish a chronic hypoxia model...
February 9, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38322970/expression-of-erythropoietin-receptor-protein-in-the-mouse-hippocampus-in-response-to-normobaric-hypoxia
#20
JOURNAL ARTICLE
F Fussing, J Christensson, G Wörtwein
BACKGROUND: Over the past decades, accumulating research on erythropoietin (EPO) and its receptor (EPOR) has revealed various neuroprotective actions and upregulation in hypoxic conditions. To our knowledge, EPOR protein levels in the hippocampus and isocortex have never been measured. Therefore, the aim of this study was to measure EPOR protein in the hippocampus (HPC) and prefrontal cortex (PFC). Further objectives were to examine the effects of exposure to normobaric hypoxia of various degrees and durations on EPOR protein and to explore how long-lasting these effects were...
February 15, 2024: Heliyon
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