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https://www.readbyqxmd.com/read/28223938/hypoxic-repeat-sprint-training-improves-rugby-player-s-repeated-sprint-but-not-endurance-performance
#1
Michael J Hamlin, Peter D Olsen, Helen C Marshall, Catherine A Lizamore, Catherine A Elliot
This study aims to investigate the performance changes in 19 well-trained male rugby players after repeat-sprint training (six sessions of four sets of 5 × 5 s sprints with 25 s and 5 min of active recovery between reps and sets, respectively) in either normobaric hypoxia (HYP; n = 9; FIO2 = 14.5%) or normobaric normoxia (NORM; n = 10; FIO2 = 20.9%). Three weeks after the intervention, 2 additional repeat-sprint training sessions in hypoxia (FIO2 = 14.5%) was investigated in both groups to gauge the efficacy of using "top-up" sessions for previously hypoxic-trained subjects and whether a small hypoxic dose would be beneficial for the previously normoxic-trained group...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28217292/oxygen-or-cooling-to-make-a-decision-after-acute-ischemia-stroke
#2
REVIEW
Wen-Cao Liu, Xin-Chun Jin
The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrained due to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic transformation (HT)...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28214553/mimicking-oxygen-delivery-and-waste-removal-functions-of-blood
#3
Huaifa Zhang, Jake E Barralet
In addition to immunological and wound healing cell and platelet delivery, ion stasis and nutrient supply, blood delivers oxygen to cells and tissues and removes metabolic wastes. For decades researchers have been trying to develop approaches that mimic these two immediately vital functions of blood. Oxygen is crucial for the long-term survival of tissues and cells in vertebrates. Hypoxia (oxygen deficiency) and even at times anoxia (absence of oxygen) can occur during organ preservation, organ and cell transplantation, wound healing, in tumors and engineering of tissues...
February 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28209739/myocardial-ischemic-tolerance-in-rats-subjected-to-endurance-exercise-training-during-adaptation-to-chronic-hypoxia
#4
Petra Alánová, Anna Chytilová, Jan Neckář, Jaroslav Hrdlička, Petra Míčová, Kristýna Holzerová, Markéta Hlaváčková, Kristýna Macháčková, František Papoušek, Jana Vašinová, Daniel Benák, Olga Nováková, František Kolář
Chronic hypoxia and exercise are natural stimuli that confer sustainable cardioprotection against ischemia/reperfusion (I/R) injury but it is unknown whether they can act in synergy to enhance ischemic resistance. Inflammatory response mediated by tumor necrosis factor-α (TNF-α) plays a role in the infarct size-limitation by continuous normobaric hypoxia (CNH) whereas exercise is associated with anti-inflammatory effects. This study was conducted to determine whether exercise training performed under conditions of CNH (12% O2) affects myocardial ischemic resistance with respect to inflammatory and redox status...
February 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28177702/modulation-of-mitochondrial-biomarkers-by-intermittent-hypobaric-hypoxia-and-aerobic-exercise-after-eccentric-exercise-in-trained-rats
#5
David Rizo-Roca, Juan Gabriel Ríos-Kristjánsson, Cristian Núñez-Espinosa, Estela Santos-Alves, José Magalhães, António Ascensão, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella
Unaccustomed eccentric contractions induce muscle damage, calcium homeostasis disruption and mitochondrial alterations. Since exercise and hypoxia are known to modulate mitochondrial function, we aimed to analyze the effects on eccentric exercise-induced muscle damage (EEIMD), in trained rats, of two recovery protocols based on: 1) intermittent hypobaric hypoxia (IHH) and 2) IHH followed by exercise. The expression of biomarkers related to mitochondrial biogenesis, dynamics, oxidative stress and bioenergetics was evaluated...
February 2, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28166940/a-10-day-confinement-to-normobaric-hypoxia-impairs-toe-but-not-finger-temperature-response-during-local-cold-stress
#6
Stylianos N Kounalakis, Michail E Keramidas, Mojca Amon, Ola Eiken, Igor B Mekjavic
The study examined the effects of a 10-day normobaric hypoxic confinement on the finger and toe temperature responses to local cooling. Eight male lowlanders underwent a normoxic (NC) and, in a separate occasion, a normobaric hypoxic confinement (HC; FO2: 0.154; simulated altitude ~3400m). Before and after each confinement, subjects immersed for 30min their right hand and, in a different session, their right foot in 8°C water, while breathing either room air (AIR) or a hypoxic gas mixture (HYPO). Throughout the cold-water immersion tests, thermal responses were monitored with thermocouples on fingers and toes...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28166699/planhab-study-assessment-of-psycho-neuroendocrine-function-in-male-subjects-during-21-days-of-normobaric-hypoxia-and-bed-rest
#7
C Strewe, R Zeller, M Feuerecker, M Hoerl, I Kumprej, A Crispin, B Johannes, T Debevec, I Mekjavic, G Schelling, A Choukèr
Immobilization and hypoxemia are conditions often seen in patients suffering from severe heart insufficiency or primary pulmonary diseases (e.g. fibrosis, emphysema). In future planned long-duration and exploration class space missions (including habitats on the moon and Mars), healthy individuals will encounter such a combination of reduced physical activity and oxygen tension by way of technical reasons and the reduced gravitational forces. These overall unconventional extraterrestrial conditions can result in yet unknown consequences for the regulation of stress-permissive, psycho-neuroendocrine responses, which warrant appropriate measures in order to mitigate foreseeable risks...
February 6, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28149414/neuroendocrine-responses-and-body-composition-changes-following-resistance-training-under-normobaric-hypoxia
#8
Jakub Chycki, Miłośz Czuba, Artur Gołaś, Adam Zając, Olga Fidos-Czuba, Adrian Młynarz, Wojciech Smółka
The aim of the present study was to evaluate the effects of a 6 week resistance training protocol under hypoxic conditions (FiO2 = 12.9%, 4000 m) on muscle hypertrophy. The project included 12 resistance trained male subjects, randomly divided into two experimental groups. Group 1 (n = 6; age 21 ± 2.4 years; body height [BH] 178.8 ± 7.3 cm; body mass [BM] 80.6 ± 12.3 kg) and group 2 (n = 6; age 22 ± 1.5 years; BH 177.8 ± 3.7cm; BM 81.1 ± 7.5 kg). Each group performed resistance exercises alternately under normoxic and hypoxic conditions (4000 m) for 6 weeks...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28135217/short-term-hypoxic-exposure-and-training-improve-maximal-anaerobic-running-test-performance
#9
Marie Oriishi, Takeo Matsubayashi, Takashi Kawahara, Yasuhiro Suzuki
The purpose of this study was to examine the effectiveness of short-term hypoxic exposure and training in the performance of competitive 400 m or 800 m runners. Fifteen female competitive 400 m and 800 m runners volunteered to participate and were assigned to either the hypoxic (n = 7) or normoxic (n = 8) group. The subjects completed 6 days of training. The hypoxic group trained and slept in normobaric hypoxia, with oxygen concentrations of 14.4% and 16.5% for training and sleep, respectively. The normoxic group trained and slept at sea level...
January 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28135110/the-influence-of-17-hours-of-normobaric-hypoxia-on-parallel-adjustments-in-exhaled-nitric-oxide-and-airway-function-in-lowland-healthy-adults
#10
Erik H Van Iterson, Eric M Snyder, Bruce D Johnson
Van Iterson, Erik H., Eric M. Snyder, and Bruce D. Johnson. The influence of 17 hours of normobaric hypoxia on parallel adjustments in exhaled nitric oxide and airway function in lowland healthy adults. High Alt Med Biol. 16:000-000, 2017.-Currently, there is a disparate understanding of the role that normobaric hypoxia plays in affecting nitric oxide (NO) measured in exhaled air (eNO) and airway function in lowland healthy adults. Compared to normobaric normoxia, this study aimed to test the effect of 17 hours of normobaric hypoxia on relationships between eNO and airway function in healthy adults...
January 30, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28133527/time-course-of-neuroprotection-induced-by-in-vivo-normobaric-hyperoxia-preconditioning-and-angiogenesis-factors
#11
Meisam Shahhoseini, Mohammad Reza Bigdeli
OBJECTIVES: Every year, a large number of people lose their lives due to stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning with hyperoxia (HO) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. Addressed in this study are beneficial contributions from HO preconditioning into reduced harm to be incurred by the attack, as well as its effect on the expression levels of vascular endothelial growth factor (VEGF) and endostatin...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28121915/moderate-exercise-increases-endotoxin-concentration-in-hypoxia-but-not-in-normoxia-a-controlled-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Paola Machado, Aline Caris, Samile Santos, Edgar Silva, Lila Oyama, Sergio Tufik, Ronaldo Santos
BACKGROUND: Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin concentration in normobaric hypoxia. METHODS: Nine healthy male volunteers exercised on a treadmill for 60 minutes at an intensity of 50% VO2peak in normoxic or hypoxic conditions (4200 m)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28111267/effect-of-acute-hypoxia-on-cognition-a-systematic-review-and-meta-regression-analysis
#13
REVIEW
Terry McMorris, Beverley J Hale, Martin Barwood, Joseph Costello, Jo Corbett
A systematic meta-regression analysis of the effects of acute hypoxia on the performance of central executive and non-executive tasks, and the effects of the moderating variables, arterial partial pressure of oxygen (PaO2) and hypobaric versus normobaric hypoxia, was undertaken. Studies were included if they were performed on healthy humans; within-subject design was used; data were reported giving the PaO2 or that allowed the PaO2 to be estimated (e.g. arterial oxygen saturation and/or altitude); and the duration of being in a hypoxic state prior to cognitive testing was ≤6days...
January 19, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28107437/hyperventilation-with-maintenance-of-isocapnia-an-old-new-method-in-carbon-monoxide-intoxication
#14
Jacek Sein Anand, Daria Schetz, Wojciech Waldman, Marek Wiśniewski
INTRODUCTION: Exposure to carbon monoxide (CO) is among the most common causes of acute and chronic poisonings worldwide. The crucial point of treatment of such acute poisonings is to eliminate CO from the body as fast as possible. There are currently two approaches to the management of the CO intoxication: hyperbaric oxygen therapy (HOT) and normobaric oxygen therapy (NOT). HOT is highly effective and capable of achieving the CO elimination half-time (T½) as low as 15 minutes. Unfortunately this method is expensive and not always readily available...
2017: PloS One
https://www.readbyqxmd.com/read/28103427/repeated-maximal-intensity-hypoxic-exercise-superimposed-to-hypoxic-residence-boosts-skeletal-muscle-transcriptional-responses-in-elite-team-sport-athletes
#15
Franck Brocherie, Grégoire P Millet, Gommaar D'Hulst, Ruud Van Thienen, Louise Deldicque, Olivier Girard
AIM: To determine whether repeated maximal-intensity hypoxic exercise induces larger beneficial adaptations on the hypoxia inducible factor-1α pathway and its target genes than similar normoxic exercise, when combined with chronic hypoxic exposure. METHODS: Lowland elite male team-sport athletes underwent 14 days of passive normobaric hypoxic exposure (≥14 h.day(-1) at Fi O2 14.5-14.2%) with the addition of six maximal-intensity exercise sessions either in normobaric hypoxia (Fi O2 ~14...
January 19, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28090139/the-blood-antioxidant-defence-capacity-during-intermittent-hypoxic-training-in-elite-swimmers
#16
S Poprzęcki, M Czuba, A Zając, J Karpiński, R Wilk, G Bril, A Maszczyk, M Toborek
The main objective of this study was to examine the chronic effect of simulated intermittent normobaric hypoxia on blood antioxidant defence capacity in swimmers. The study included 14 male and 14 female competitive swimmers performing part of land training under simulated intermittent normobaric hypoxia (O2 = 15.5%) or in normoxia. Land interval training took place twice per week, with a total of 8 training units during the study, performed with individualized intensity. The activities of blood antioxidant enzymes did not change significantly during the first and last training unit in the hypoxic and normoxic group...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28069461/is-acute-mountain-sickness-related-to-trait-anxiety-a-normobaric-chamber-study
#17
Martin Niedermeier, Robb Waanders, Verena Menz, Maria Wille, Martin Kopp, Martin Burtscher
INTRODUCTION: Some mountaineers are more prone to the occurrence of acute mountain sickness (AMS) than others. State anxiety during altitude exposure might be associated with AMS development. We hypothesized that trait anxiety might be higher in AMS cases compared to non-AMS cases. The aim of the present study was to study the relationship between AMS development and trait anxiety. METHODS: In an observational study design, AMS incidence during a 12-hour exposure to normobaric hypoxia (FiO2=12...
January 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28065873/hyperbaric-oxygen-effects-on-depression-like-behavior-and-neuroinflammation-in-traumatic-brain-injury-rats
#18
Sher-Wei Lim, Kuan-Chin Sung, Yow-Ling Shiue, Che-Chuan Wang, Chung-Ching Chio, Jinn-Rung Kuo
OBJECTIVE: The aim of this study was to determine whether hyperbaric oxygen (HBO) therapy causes attenuation of traumatic brain injury (TBI)-induced depression-like behavior and its associated anti-neuroinflammatory effects after fluid percussion injury. METHODS: Anesthetized male Sprague-Dawley rats were divided into three groups: sham operation + NBA (normobaric air: 21% O2 at 1 absolute atmosphere [ATA]), TBI + NBA, and TBI + HBO (100% O2 at 2.0 ATA). HBO was applied immediately for 60 min/day after TBI for 3 days...
January 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28065733/amelioration-of-apelin-13-in-chronic-normobaric-hypoxia-induced-anxiety-like-behavior-is-associated-with-an-inhibition-of-nf-%C3%AE%C2%BAb-in-the-hippocampus
#19
Junming Fan, Lu Ding, Dongmei Xia, Danyang Chen, Pu Jiang, Wenhua Ge, Ru Zhao, Jinbin Guo, Xiaofang Fan, Feng Xue, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gong
Apelin, a small bioactive peptide, plays an important role in the pathogenesis of mood disorders through the endogenous ligand APJ. Although the anxiolytic effect of apelin is well established, the mechanisms are poorly understood. In this study, we hypothesized that apelin played an anxiolytic role in chronic normobaric hypoxia (CNH)-induced anxiety like behavior in mice, which might be associated with an inhibition of nuclear factor-κB (NF-κB) activation in the hippocampus. To this end, mice were exposed in a normobaric hypoxic chamber with a fraction of inspired oxygen (FIO2, ∼10%, 23h/d) with or without apelin-13 application (20 nmolkg(-1)d(-1), i...
January 5, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28029165/efficiency-of-endothelial-dysfunctioncorrection-in-children-residents-of-radioactively-contaminated-areas-using-the-method-of-intermittent-normobaric-hypoxi-therapy
#20
Ye I Stepanova, V Ya Berezovsky, I Ye Kolpakov, V H Kondrashova, V Yu Vdovenko, O M Lytvynets, L M Lisukha, V M Zyhalo, V I Kolos, L P Mishchenko
: Objective is to evaluate the effectiveness of intermittent normobaric hypoxi therapy as the means that can posi tively influence on the different links in the pathogenesis of endothelial dysfunction in children residents of radioactively contaminated areas. MATERIALS AND METHODS: Disorders of personal and emotional sphere, symptoms of asthenic vegetative and neurot ic character, the signs of the cardiovascular and respiratory systems, abdominal and dyspeptic syndromes are attrib uted to the clinical signs of endothelial dysfunction...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
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