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https://www.readbyqxmd.com/read/29327542/-treatment-of-coronal-shear-fracture-of-the-distal-end-of-the-humerus-by-the-olecranon-osteotomy-approach
#1
Xiu-Wu Guo, Jian Fan, Feng Yuan
OBJECTIVE: To explore the effectiveness of olecranon osteotomy approach for the treatment of coronal shear fracture of the distal end of the humerus. METHODS: A retrospective analysis was made on the clinical data of 34 patients with the coronal shear fracture of the distal end of the humerus treated by the olecranon osteotomy approach from January 2005 to January 2013. Of 34 cases, there were 15 boys and 19 girls, aged from 17 years to 84 years (mean, 54.9±10...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327541/-mini-locking-plates-for-the-treatment-of-regan-morrey-type-iii-fracture-of-ulnar-coronoid-process-through-anterior-approach-of-elbow-joint
#2
Xiao Lian, Yun-Ji Zeng
OBJECTIVE: To explore clinical effects of mini-locking plates for the treatment of Regan-Morrey type III fractures of ulnar coronoid process through an anterior approach of elbow joint. METHODS: A retrospective analysis on 12 patients with Regan-Morrey type III fractures of the ulnar coronoid process was performed from January 2011 to June 2014, who were treated with unini-locking plates through the anterior approach of elbow joint. There were 7 males and 5 females, ranging in age from 23 to 65 years old, averaged 43 years old...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29325942/perineural-spread-of-melanoma-to-the-brachial-plexus-identifying-the-anatomic-pathway-s
#3
Tomas Marek, Ruple S Laughlin, B Matthew Howe, Robert J Spinner
BACKGROUND: Perineural spread of melanoma is a well-known mechanism of metastasis in cases involving cranial nerves. Brachial plexus involvement is rare and the pathway is unknown. METHODS: A retrospective review of the Mayo Clinic database was performed to identify patients with a history of melanoma and brachial plexus compromise between 1994 and 2017. Inclusion criteria were a history of melanoma, a clinical diagnosis of brachial plexopathy, radiological features consistent with perineural spread and biopsy of melanoma within nerve...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29321518/mediation-analysis-of-alcohol-consumption-dna-methylation-and-epithelial-ovarian-cancer
#4
Dongyan Wu, Haitao Yang, Stacey J Winham, Yanina Natanzon, Devin C Koestler, Tiane Luo, Brooke L Fridley, Ellen L Goode, Yanbo Zhang, Yuehua Cui
Epigenetic factors and consumption of alcohol, which suppresses DNA methylation, may influence the development and progression of epithelial ovarian cancer (EOC). However, there is a lack of understanding whether these factors interact to affect the EOC risk. In this study, we aimed to gain insight into this relationship by identifying leukocyte-derived DNA methylation markers acting as potential mediators of alcohol-associated EOC. We implemented a causal inference test (CIT) and the VanderWeele and Vansteelandt multiple mediator model to examine CpG sites that mediate the association between alcohol consumption and EOC risk...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29305082/hyperglycemic-chorea-ballism-ascertained-over-15-years-at-a-referral-medical-center
#5
Conor Ryan, J Eric Ahlskog, Rodolfo Savica
OBJECTIVE: To describe chorea/ballism triggered by a hyperglycemic event. METHODS: We used the electronic records system at Mayo Clinic-Rochester to identify patients diagnosed with chorea or ballism from January 1st, 2000 through December 31st, 2014. Each record was reviewed to confirm chorea/ballism. From these cases we selected those that developed chorea/ballism within a month after a hyperglycemic episode (blood glucose >300 mg/dL). Clinical, laboratory, and imaging findings were analyzed...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29274766/infliximab-trough-levels-and-persistent-vs-transient-antibodies-measured-early-after-induction-predict-long-term-clinical-remission-in-patients-with-inflammatory-bowel-disease
#6
Giorgia Bodini, Edoardo G Giannini, Vincenzo Savarino, Lorenzo Del Nero, Sara Lo Pumo, Matteo Brunacci, Nicola De Bortoli, Anjali Jain, Salvatore Tolone, Edoardo Savarino
BACKGROUND: The use of therapeutic drug monitoring has been proposed as a useful tool in the management of patients with loss of response to biological therapy in patients with inflammatory bowel disease. AIMS: To evaluate whether early, post-induction anti-tumor necrosis factor trough levels and the presence of different types of anti-drug antibodies may impact long-term clinical remission in patients with inflammatory bowel disease. METHODS: We prospectively assessed anti-tumor necrosis factor trough levels and both persistent and transient anti-drug antibodies...
November 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29261826/communication-about-the-probability-of-cancer-in-indeterminate-pulmonary-nodules
#7
Amelia W Maiga, Stephen A Deppen, Pierre P Massion, Carol Callaway-Lane, Rhonda Pinkerman, Robert S Dittus, Eric S Lambright, Jonathan C Nesbitt, Eric L Grogan
Importance: Clinical guidelines recommend that clinicians estimate the probability of malignancy for patients with indeterminate pulmonary nodules (IPNs) larger than 8 mm. Adherence to these guidelines is unknown. Objectives: To determine whether clinicians document the probability of malignancy in high-risk IPNs and to compare these quantitative or qualitative predictions with the validated Mayo Clinic Model. Design, Setting, and Participants: Single-institution, retrospective cohort study of patients from a tertiary care Department of Veterans Affairs hospital from January 1, 2003, through December 31, 2015...
December 20, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29247071/evaluation-of-idiopathic-transverse-myelitis-revealing-specific-myelopathy-diagnoses
#8
Nicholas L Zalewski, Eoin P Flanagan, B Mark Keegan
OBJECTIVE: To evaluate specific myelopathy diagnoses made in patients with suspected idiopathic transverse myelitis (ITM). METHODS: A total of 226 patients 18 years and older were referred to Mayo Clinic Neurology for suspected ITM from December 1, 2010, to December 31, 2015. Electronic medical records were reviewed for detailed clinical presentation and course, laboratory and electrophysiologic investigations, and neuroimaging to determine the etiology. Current diagnostic criteria for ITM and alternative myelopathy diagnoses were applied...
December 15, 2017: Neurology
https://www.readbyqxmd.com/read/29243817/association-between-atopic-dermatitis-and-squamous-cell-carcinoma-a-case-control-study
#9
Janice M Cho, Dawn Marie R Davis, David A Wetter, Adam C Bartley, Jerry D Brewer
BACKGROUND: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. METHODS: We conducted a retrospective, case-control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29240012/surgical-treatment-of-chronic-elbow-dislocation-allowing-early-range-of-motion-operative-technique-and-clinical-results
#10
Duane R Anderson, Justin M Haller, Lucas A Anderson, Samuel Hailu, Abebe Chala, Shawn W O'Driscoll
OBJECTIVES: Describe the surgical treatment and patient outcomes of chronic elbow dislocations. DESIGN: Retrospective review SETTING:: Two tertiary referral centers. PATIENTS/PARTICIPANTS: All patients with surgically treated chronic elbow dislocation with no associated articular fracture from January 2009 - January 2015. INTERVENTION: Review of patient demographics, injury chronicity, surgical technique, and patient outcomes...
December 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29231254/characteristics-of-pediatric-recurrent-erythema-multiforme
#11
Adam Heinze, Megha Tollefson, Kristen E Holland, Yvonne E Chiu
BACKGROUND: Erythema multiforme (EM) is an acute condition characterized by distinctive target lesions of the skin often accompanied by mucosal ulcers. A subset of individuals experience frequent episodes of recurrent EM, which is rare and poorly understood, especially in children. OBJECTIVE: To characterize clinical features, laboratory findings, and treatment responses of pediatric recurrent EM. METHODS: A retrospective chart review was conducted at the Children's Hospital of Wisconsin in Milwaukee, Wisconsin (2000-2015) and the Mayo Clinic in Rochester, Minnesota (1990-2015)...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29229541/results-of-percutaneous-fixation-and-distal-radius-core-decompression-in-scaphoid-waist-non-unions-treated-without-grafting
#12
S S Dedeoğlu, Y İmren, H Çabuk, A C Tekin, Y C Türe, H Gürbüz
Scaphoid non-union management is still a challenge in clinical practice for orthopaedic surgeons. Though several treatment methods have been described, there is an ongoing debate about optimum management. Based on new concepts about avascular conditions, promising results were reported with metaphyseal decompression of the distal radius by increasing the vascularization of the radial column of the carpus. We aimed to evaluate the clinical, radiological, and functional outcomes of distal radius core decompression and fixation with palmar percutaneous cannulated compression screws without grafting in patients with scaphoid waist fracture non-union...
December 8, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29228467/neoadjuvant-systemic-therapy-for-regionally-advanced-melanoma
#13
James W Jakub, Jennifer M Racz, Tina J Hieken, Alexandra B Gonzalez, Lisa A Kottschade, Svetomir N Markovic, Yiyi Yan, Mathew S Block
BACKGROUND: Patients with regionally advanced melanoma are at high risk of distant failure and unlikely to be cured by surgery alone. Neoadjuvant therapy may provide benefit in these patients. OBJECTIVES: To evaluate our experience with neoadjuvant systemic therapy in high-risk stage III patients. METHODS: Retrospective review of patients with advanced stage III disease who received neoadjuvant therapy between August 2009 and August 2016 at Mayo Clinic Rochester...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29221687/leptomeningeal-carcinomatosis-in-colorectal-cancer-the-mayo-clinic-experience
#14
Gretchen Taylor, Nina Karlin, Thorvardur R Halfdanarson, Kyle Coppola, Axel Grothey
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon form of metastatic disease in many cancers. There remains a paucity of literature with regard to the course and management of LM in colorectal cancers (CRCs). The aim of this study was to estimate the incidence of LM in patients with CRC seen at our institution over a 15-year period, and to describe the clinical course and outcome of these cases. METHODS: LM in CRC primary cases between 2000 and 2014 were identified in the Mayo Clinic databases...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29214396/triple-management-of-cubitus-valgus-deformity-complicating-neglected-nonunion-of-fractures-of-lateral-humeral-condyle-in-children-a-case-series
#15
Yasser Abed, Khaled Nour, Yasser Roshdy Kandil, Abed El-Negery
BACKGROUND: Long standing nonunion of the lateral humeral condyle (LHC) usually results in elbow pain and instability with progressive cubitus valgus and tardy ulnar neuritis. Surgical treatment of long standing nonunion is still a controversial issue due to the reported complications, such as stiffness, loss of elbow motion, and avascular necrosis of the LHC fragment. In this study, we reported the outcomes of treatment of cubitus valgus deformity in long standing nonunion of the LHC in children treated with combined triple management (fixation of the nonunion site, dome corrective osteotomy, and anterior transposition of ulnar nerve) through a modified para-triceptal approach...
December 6, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29214010/giant-cell-tumour-of-the-distal-radius-ulna-response-to-pre-operative-treatment-with-short-term-denosumab
#16
Catherine L McCarthy, Christopher L M H Gibbons, Kevin M Bradley, A Bass Hassan, Henk Giele, Nicholas A Athanasou
Background: Treatment of giant cell tumour of bone (GCTB) of the distal radius/ulna poses a surgical challenge, as complex reconstructive surgery may be required. This study evaluates the clinical, radiological and pathological findings in five cases of GCTB of the distal forearm where a 3 month course of denosumab was given prior to surgery. Methods: Patients with biopsy proven distal forearm GCTB, treated for 3 months with denosumab, followed by salvage surgery (curettage and cementation) were included...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29210929/optic-disc-edema-in-glial-fibrillary-acidic-protein-autoantibody-positive-meningoencephalitis
#17
John J Chen, Allen J Aksamit, Andrew McKeon, Sean J Pittock, Brian G Weinshenker, Jacqueline A Leavitt, Padraig P Morris, Eoin P Flanagan
BACKGROUND: Glial fibrillary acidic protein (GFAP) autoantibody-positive meningoencephalitis is a newly described entity characterized by a corticosteroid-responsive meningoencephalomyelitis. Some patients with GFAP autoantibody-positive meningoencephalitis have been found to have optic disc edema, which has previously not been well characterized. METHODS: We performed a retrospective, observational case series of Mayo Clinic patients found to have GFAP-IgG and optic disc edema from January 1, 2000, to December 31, 2016...
November 21, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29209741/total-elbow-arthroplasty-under-unfavourable-soft-tissue-conditions
#18
Hwan Jin Kim, Jung Youn Kim, Young Moon Kee, Yong Girl Rhee
PURPOSE: To evaluate the clinical and radiographic outcomes of patients with total elbow arthroplasty (TEA) and soft tissue reconstruction. METHODS: We investigated six patients who underwent TEA and soft tissue reconstruction (two elbows with 1-stage surgery and four elbows with 2-stage surgery). The mean patient age at the time of the surgical procedure was 43.2 years; the mean follow-up duration was 88.2 months. RESULTS: The mean pain visual analogue scale (VAS) during motion was improved from 6...
December 5, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29202185/clinical-documentation-variations-and-nlp-system-portability-a-case-study-in-asthma-birth-cohorts-across-institutions
#19
Sunghwan Sohn, Yanshan Wang, Chung-Il Wi, Elizabeth A Krusemark, Euijung Ryu, Mir H Ali, Young J Juhn, Hongfang Liu
Objective: To assess clinical documentation variations across health care institutions using different electronic medical record systems and investigate how they affect natural language processing (NLP) system portability. Materials and Methods: Birth cohorts from Mayo Clinic and Sanford Children's Hospital (SCH) were used in this study (n = 298 for each). Documentation variations regarding asthma between the 2 cohorts were examined in various aspects: (1) overall corpus at the word level (ie, lexical variation), (2) topics and asthma-related concepts (ie, semantic variation), and (3) clinical note types (ie, process variation)...
November 30, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29200081/pd-1-inhibitor-associated-myopathies-emerging-immune-mediated-myopathies
#20
Teerin Liewluck, Justin C Kao, Michelle L Mauermann
Programmed death-1 (PD-1) inhibitors are increasingly used in cancer immunotherapy. Various immune-related adverse events are reported, including infrequent individual case reports of myositis or rhabdomyolysis. The frequency and diagnostic spectrum of immune-related adverse events affecting skeletal muscle in PD-1 inhibitor-treated patients are unknown. We searched the Mayo Clinic Pharmacy database (2014-2016) to identify patients who developed myopathies during or after PD-1 inhibitor therapy. Among 654 cancer patients received PD-1 inhibitors (pembrolizumab=389; nivolumab=264; both=1), we identified 5 patients (pembrolizumab=5) with biopsy-proven myopathies (2 necrotizing myopathy, 1 early dermatomyositis, and 2 nonspecific myopathy)...
December 1, 2017: Journal of Immunotherapy
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