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Biomarkers of frailty

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https://www.readbyqxmd.com/read/29684114/exploring-genetic-outcomes-as-frailty-biomarkers
#1
Vanessa Valdiglesias, María Sánchez-Flores, Diego Marcos-Pérez, Laura Lorenzo-López, Ana Maseda, José C Millán-Calenti, Eduardo Pásaro, Blanca Laffon
Frailty has emerged as a reliable measure of the aging process. Since the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective identification of frail individuals. In order to improve the understanding of the biological features associated with frailty as well as to explore different biomarkers for its early identification, several genetic outcomes - mutagenicity, different types of genetic damage, and cellular repair capacity - were analysed in a population of older adults classified into frail, pre-frail and non-frail...
April 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29628032/-clinical-assessment-and-diagnostic-tools
#2
Pedro Gil Gregorio
The presence of cognitive impairment generates important changes in both affected individuals and their families and the health staff who must provide adequate care. Early identification of this alteration allows appropriate diagnosis and treatment and psychosocial and educational support, as well as the possibility of establishing care, life and financial plans. The interest of the scientific community in age-related cognitive alterations is demonstrated by the abundance of criteria and classifications. Obviously, there is a need to unify these criteria and implement longitudinal studies in order to reach reliable conclusions...
June 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29607322/identifying-frail-related-biomarkers-among-community-dwelling-older-adults-in-japan-a-research-example-from-the-japanese-gerontological-evaluation-study
#3
N Cable, A Hiyoshi, N Kondo, J Aida, H Sjöqvist, K Kondo
We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants ( N = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29549539/a-review-of-telomere-length-in-sarcopenia-and-frailty
#4
REVIEW
Maria Lorenzi, Stefano Bonassi, Teresa Lorenzi, Silvia Giovannini, Roberto Bernabei, Graziano Onder
Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. In addition, telomere length (TL) is widely considered a molecular/cellular hallmark of the ageing process...
March 16, 2018: Biogerontology
https://www.readbyqxmd.com/read/29527132/risk-assessment
#5
REVIEW
Pragya Ajitsaria, Sabry Z Eissa, Ross K Kerridge
Purpose of Review: The central question of preoperative assessment is not "What can be done?" but "What should be done and how?" Predicting a patient's risk of unwanted outcomes is vital to answering this question. This review discusses risk prediction tools currently available and anticipates future developments. Recent Findings: Simple, parsimonious risk scales and scores are being replaced by complex risk prediction models as high-capacity information systems become ubiquitous...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29526272/different-perspectives-on-predictability-and-preventability-of-surgical-readmissions
#6
Louise S van Galen, Daisy Vedder, Tom Boeije, Wilma Jansen, Nieke E Mullaart-Jansen, Donald L van der Peet, Ralph K L So, Prabath W B Nanayakkara
BACKGROUND: Although unscheduled readmissions are increasingly being used as a quality indicator, only few readmission studies have focused on surgical patient populations. METHODS: An observational study "CURIOS@" was performed at three centers in the Netherlands. Readmitted patients and treating doctors were surveyed to assess the discharge process during index admission and their opinion on predictability and preventability of the readmission. Risk factors associated with predictability and preventability as judged by patients and their doctor were identified...
March 8, 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29351781/mindmap-establishing-an-integrated-database-infrastructure-for-research-in-ageing-mental-well-being-and-the-urban-environment
#7
Mariëlle A Beenackers, Dany Doiron, Isabel Fortier, J Mark Noordzij, Erica Reinhard, Emilie Courtin, Martin Bobak, Basile Chaix, Giuseppe Costa, Ulrike Dapp, Ana V Diez Roux, Martijn Huisman, Emily M Grundy, Steinar Krokstad, Pekka Martikainen, Parminder Raina, Mauricio Avendano, Frank J van Lenthe
BACKGROUND: Urbanization and ageing have important implications for public mental health and well-being. Cities pose major challenges for older citizens, but also offer opportunities to develop, test, and implement policies, services, infrastructure, and interventions that promote mental well-being. The MINDMAP project aims to identify the opportunities and challenges posed by urban environmental characteristics for the promotion and management of mental well-being and cognitive function of older individuals...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29346525/frailty-syndrome-and-genomic-instability-in-older-adults-suitability-of-the-cytome-micronucleus-assay-as-a-diagnostic-tool
#8
María Sánchez-Flores, Diego Marcos-Pérez, Laura Lorenzo-López, Ana Maseda, José C Millán-Calenti, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of frail individuals and improving frailty outcomes. Our objective was to evaluate the potential of the micronucleus (MN) frequency, evaluated in lymphocytes and buccal cells, to anticipate frailty identification and improve diagnosis reliability. Our results, from a group of older adults over 65, showed that frail individuals had significantly higher frequencies of MN in lymphocytes (19...
January 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29297391/personalized-physiological-medicine
#9
REVIEW
Can Ince
This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medicine, characterized by biomarkers and gene profiling, instead focusing on time-variant changes in the pathophysiology and regulation of various organ systems and their cellular and subcellular constituents. I propose that personalized physiological medicine is composed of four pillars relevant to the critically ill patient...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29290100/circulating-levels-of-monocyte-chemoattractant-protein-1-as-a-potential-measure-of-biological-age-in-mice-and-frailty-in-humans
#10
Matthew J Yousefzadeh, Marissa J Schafer, Nicole Noren Hooten, Elizabeth J Atkinson, Michele K Evans, Darren J Baker, Ellen K Quarles, Paul D Robbins, Warren C Ladiges, Nathan K LeBrasseur, Laura J Niedernhofer
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein-1 (MCP-1) levels increased in an age-dependent manner in wild-type (WT) mice...
April 2018: Aging Cell
https://www.readbyqxmd.com/read/29203402/lamin-a-expression-in-circulating-osteoprogenitors-as-a-potential-biomarker-for-frailty-the-nepean-osteoporosis-and-frailty-nof-study
#11
Ahmed Al Saedi, Piumali Gunawardene, Sandra Bermeo, Sara Vogrin, Derek Boersma, Steven Phu, Lakshman Singh, Pushpa Suriyaarachchi, Gustavo Duque
Lamin A is a protein of the nuclear lamina. Low levels of lamin A expression are associated with osteosarcopenia in mice. In this study, we hypothesized that low lamin A expression is also associated with frailty in humans. We aimed to develop a non-invasive method to quantify lamin A expression in epithelial and circulating osteoprogenitor (COP) cells, and to determine the relationship between lamin A expression and frailty in older individuals. COP cells and buccal swabs were obtained from 66 subjects (median age 74; 60% female; 26 non-frail, 23 pre-frail, and 17 frail) participating at the Nepean Osteoporosis and Frailty (NOF) Study...
February 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29176992/immunosenescence-in-persons-with-spinal-cord-injury-in-relation-to-urinary-tract-infections-a-cross-sectional-study
#12
David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek, Jivko Stoyanov
Background: Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinary tract infections (UTI) have been identified as the leading causes of mortality. We hypothesise that a premature onset of immune frailty occurs in SCI, possibly caused also by recurrent urinary tract infections.A cross sectional study was performed comparing blood and urine samples between able bodied controls ( n  = 84) and persons with spinal cord injury ( n  = 85)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29159972/vitamin-b12-deficiency-and-impaired-expression-of-amnionless-during-aging
#13
Alice Pannérec, Eugenia Migliavacca, Antonio De Castro, Joris Michaud, Sonia Karaz, Laurence Goulet, Serge Rezzi, Tze Pin Ng, Nabil Bosco, Anis Larbi, Jerome N Feige
BACKGROUND: Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age-related chronic diseases, including in the musculo-skeletal system, where vitamin B12 deficiency is generally believed to be linked to poor nutritional intake. In the present study, we asked whether aging and frailty associate with altered vitamin B12 homeostasis in humans and investigated the underlying molecular mechanisms using preclinical models...
February 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29081654/association-between-serum-%C3%AE-2-microglobulin-levels-and-frailty-in-an-elderly-chinese-population-results-from-rulas
#14
Zu-Yun Liu, Yan-Yu Shen, Li-Juan Ji, Xiao-Yan Jiang, Xiao-Feng Wang, Yan Shi
OBJECTIVE: To examine the association between serum β2-microglobulin (B2M) levels and frailty in an elderly Chinese population. DESIGN: A population-based cohort study. SETTING AND PARTICIPANTS: We used data on 1,663 elderly participants (aged 70-84 years) from the aging arm of the Rugao Longevity and Ageing study, a population-based observational two-arm cohort study conducted in Rugao, China. MEASUREMENTS: The serum B2M was measured with chemiluminescence immunoassay by a technician in the biochemistry laboratory of the Rugao People's Hospital...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29079029/relationship-between-sarcopenia-and-frailty-in-the-toledo-study-of-healthy-aging-a-population-based-cross-sectional-study
#15
B Davies, F García, I Ara, F Rodríguez Artalejo, L Rodriguez-Mañas, S Walter
INTRODUCTION: Frailty and sarcopenia are correlates of musculoskeletal aging that represent a state of vulnerability increasing the risk of negative health outcomes. Standardized definitions are lacking for both, and sometimes both concepts are used interchangeably. However, no large study has assessed the coexistence of these 2 entities in a cohort of older community-dwelling people. METHODS: Data were taken from the Toledo Study of Healthy Aging (TSHA), a study of community-dwelling elderly (≥65 years)...
October 24, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29069339/is-placental-malaria-a-long-term-risk-factor-for-mild-malaria-attack-in-infancy-revisiting-a-paradigm
#16
Olivier Bouaziz, David Courtin, Gilles Cottrell, Jacqueline Milet, Gregory Nuel, André Garcia
Background: Children born to mothers with placental malaria (PM) have been described as more susceptible to the occurrence of a first malaria infection. However, whether or not these children remain more at risk during infancy has never been explored. We aimed to determine if children born to mothers with PM are more susceptible to malaria and remain at higher risk between birth and 18 months. Methods: 550 children were weekly followed-up with control of temperature and, if >37...
October 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29032243/dna-methylation-patterns-are-related-to-co-morbidity-status-and-circulating-c-reactive-protein-levels-in-the-nursing-home-elderly
#17
Chris P Verschoor, Lisa M McEwen, Michael S Kobor, Mark B Loeb, Dawn M E Bowdish
Elderly residents of long-term care commonly exhibit a number of age-related health deficits, including impaired physical and cognitive function, chronic illnesses, and chronic inflammation. Given our previous data relating the phenotype and function of innate and adaptive leukocytes from the nursing home elderly to chronic conditions and inflammatory biomarkers, we hypothesized that these factors would influence the regulatory programming of immune cells, thereby contributing to immune dysfunction. Since DNA methylation represents both an important regulatory mechanism of cells as well as a biomarker of health and disease, we sought to characterize the methylome of peripheral blood mononuclear cells (PBMCs) from the nursing home elderly (n=23; 82-98years old, 70% female), and compare these patterns to pathological factors such as dementia, co-morbidity score and frailty, and immune-related factors such as serum C-reactive protein (CRP) and cytokine levels and varicella-zoster virus (VZV) vaccine responsiveness...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28977399/allogeneic-mesenchymal-stem-cells-ameliorate-aging-frailty-a-phase-ii-randomized-double-blind-placebo-controlled-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Bryon A Tompkins, Darcy L DiFede, Aisha Khan, Ana Marie Landin, Ivonne Hernandez Schulman, Marietsy V Pujol, Alan W Heldman, Roberto Miki, Pascal J Goldschmidt-Clermont, Bradley J Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Moisaniel Da Fonseca, Samuel Golpanian, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Geoff Green, Anthony A Oliva, Joshua M Hare
Background: Aging frailty, characterized by decreased physical and immunological functioning, is associated with stem cell depletion. Human allogeneic mesenchymal stem cells (allo-hMSCs) exert immunomodulatory effects and promote tissue repair. Methods: This is a randomized, double-blinded, dose-finding study of intravenous allo-hMSCs (100 or 200-million [M]) vs placebo delivered to patients (n = 30, mean age 75.5 ± 7.3) with frailty. The primary endpoint was incidence of treatment-emergent serious adverse events (TE-SAEs) at 1-month postinfusion...
October 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28977375/cross-sectional-and-longitudinal-relationships-between-inflammatory-biomarkers-and-frailty-in-community-dwelling-older-men-the-concord-health-and-ageing-in-men-project
#19
Benjumin Hsu, Vasant Hirani, Robert G Cumming, Vasi Naganathan, Fiona M Blyth, Fredrick C Wright, Louise M Waite, Markus J Seibel, David J Handelsman, David G Le Couteur
Background: Previous studies demonstrated associations between IL-6 and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied. Methods: Community-dwelling men aged more than 75 enrolled in the 5-year and 8-year follow-up of the CHAMP study were assessed. Twenty-seven inflammatory biomarkers were measured using the Bio-Plex Pro Human Cytokine 27-plex Assay kit at 5-year follow-up...
July 28, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28977345/men-sustain-higher-dysregulation-levels-than-women-without-becoming-frail
#20
Alan A Cohen, Véronique Legault, Qing Li, Linda P Fried, Luigi Ferrucci
The aging process differs in important ways between the sexes, with women living longer but at higher risk for frailty (the male-female health-survival paradox). The underlying biological mechanisms remain poorly understood, but may relate to sex differences in physiological dysregulation patterns. Here, using biomarkers from two longitudinal cohort studies (InCHIANTI and BLSA) and one cross-sectional survey (NHANES), we assess sex differences in trajectories of dysregulation globally and for five physiological systems: oxygen transport, electrolytes, hematopoiesis, lipids, and liver/kidney function...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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