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Biomarkers of frailty

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https://www.readbyqxmd.com/read/28723411/the-risks-of-biomarker-based-epidemiology-associations-of-circulating-calcium-levels-with-age-mortality-and-frailty-vary-substantially-across-populations
#1
REVIEW
Alan A Cohen, Véronique Legault, Georg Fuellen, Tamàs Fülöp, Linda P Fried, Luigi Ferrucci
Recent studies have shown contradictory associations between calcium levels and health outcomes. We suspected these conflicting results were the consequence of more general issues with how biomarkers are analyzed in epidemiological studies, particularly in the context of aging. To demonstrate the risks of typical analyses, we used three longitudinal aging cohort studies and their demographic subsets to analyze how calcium levels change with age and predict risk of mortality and frailty. We show that calcium levels either increase or decrease with age depending on the population, and positively or negatively predict frailty depending on the population; both age and frailty results showed substantial heterogeneity...
July 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28676292/intestinal-permeability-biomarker-zonulin-is-elevated-in-healthy-aging
#2
YanFei Qi, Ruby Goel, Seungbum Kim, Elaine M Richards, Christy S Carter, Carl J Pepine, Mohan K Raizada, Thomas W Buford
INTRODUCTION: Increased gut permeability ("leaky gut") has been proposed as a potential contributor to age-related inflammation and gut dysbiosis. However, information on the relationship between a leaky gut and inflammation and physical frailty during aging are limited. OBJECTIVE: To investigate the hypothesis that an aging-associated leaky gut is linked to the age-related inflammation and frailty. METHODS: Two cohorts of healthy adults were studied: young (18-30 years old, n = 19) and older (≥70 years old, n = 18)...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28665517/a-cumulative-deficit-laboratory-test-based-frailty-index-personal-and-neighborhood-associations
#3
Katherine E King, Gerda G Fillenbaum, Harvey J Cohen
OBJECTIVES: To explore the association between a newly developed cumulative laboratory-based frailty index (FI) and intrinsic (personal) and extrinsic (social, environmental) characteristics. DESIGN: Cross-sectional longitudinal study. SETTING: The third and fourth waves of the community-representative, five-county, 10-year Duke Established Populations for Epidemiologic Studies of the Elderly study, carried out in a health service-rich area...
June 30, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28663354/feeding-the-microbiota-transducer-of-nutrient-signals-for-the-host
#4
REVIEW
Fergus Shanahan, Douwe van Sinderen, Paul W O'Toole, Catherine Stanton
Advances in microbiome science cast light on traditional concepts on nutritional science, and are poised for clinical translation. Epidemiologic observations which linked lifestyle factors to risk of disease are being re-interpreted with mechanistic insight based on improved understanding of the microbiota. Examples include the role of dietary fibre in disease prevention, the deleterious effects of highly restricted diets, and the contribution of the microbiota to over- and undernutrition. While the microbiota transduces nutrient signals for the host, food and habitual diet shape the composition of the gut microbiota at every stage of life...
June 29, 2017: Gut
https://www.readbyqxmd.com/read/28658942/cellular-senescence-biomarker-p16ink4a-cell-burden-in-thigh-adipose-is-associated-with-poor-physical-function-in-older-women
#5
Jamie N Justice, Heather Gregory, Tamar Tchkonia, Nathan K LeBrasseur, James L Kirkland, Stephen B Kritchevsky, Barbara J Nicklas
Background: Ample evidence implicates cellular senescence as a contributor to frailty and functional decline in rodents, but considerable effort remains to translate these findings to human aging. Methods: We quantified senescence biomarker p16INK4a-expressing cells in thigh adipose tissue obtained from older women previously enrolled in a 5-month resistance training intervention, with or without caloric restriction (RT±CR, n=11 baseline, 8 pre-post-intervention pairs)...
June 27, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28544527/biomarkers-associated-with-mortality-in-patients-undergoing-dialysis
#6
Ana Rebollo Rubio, Jose Miguel Morales Asencio, Mª Eugenia Pons Raventos
BACKGROUND: Survival for patients commencing renal replacement therapy is around 90% in the first year and 83% at two years after starting dialysis. The factors that appear to predict mortality are comorbidity and frailty associated with kidney disease, glomerular filtration rate, age and biochemical factors. OBJECTIVES: To analyse the condition of patients starting renal replacement therapy, based on biomarkers commonly used in clinical practice and their association with mortality, measured 6 and 12 months after initiating replacement therapy...
May 23, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28542531/new-diagnostic-index-for-sarcopenia-in-patients-with-cardiovascular-diseases
#7
Haruhito Harada, Hisashi Kai, Rei Shibata, Hiroshi Niiyama, Yasuhiro Nishiyama, Toyoaki Murohara, Noriko Yoshida, Atsushi Katoh, Hisao Ikeda
BACKGROUND: Sarcopenia is an aging and disease-related syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, with the risk of frailty and poor quality of life. Sarcopenia is diagnosed by a decrease in skeletal muscle index (SMI) and reduction of either handgrip strength or gait speed. However, measurement of SMI is difficult for general physicians because it requires special equipment for bioelectrical impedance assay or dual-energy X-ray absorptiometry...
2017: PloS One
https://www.readbyqxmd.com/read/28496545/c-reactive-protein-and-frailty-in-the-elderly-a-literature-review
#8
REVIEW
Dimitrios Velissaris, Nikolaos Pantzaris, Ioanna Koniari, Nikolaos Koutsogiannis, Vasilios Karamouzos, Ioanna Kotroni, Anastasia Skroumpelou, John Ellul
Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28488297/frailty-in-older-adults-with-amnestic-mild-cognitive-impairment-as-a-result-of-alzheimer-s-disease-a-comparison-of-two-models-of-frailty-characterization
#9
Natália O C Cezar, Rafael Izbicki, Diego Cardoso, Jouce G Almeida, Leandro Valiengo, Marina V Z Camargo, Orestes V Forlenza, Monica S Yassuda, Ivan Aprahamian
AIM: To verify the prevalence and presence of frailty markers, and their relationship to cognitive function among older adults with amnestic mild cognitive impairment (aMCI). METHODS: This was an observational study with transversal analyses. Older adults with aMCI as a result of Alzheimer's disease (n = 40) were compared with healthy controls (n = 26) at the Psychogeriatric Outpatient Unit, Institute and Department of Psychiatry, Faculty of Medicine of the University of São Paulo...
May 10, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28487242/oxidative-stress-genomic-features-and-dna-repair-in-frail-elderly-a-systematic-review
#10
REVIEW
María Sánchez-Flores, Diego Marcos-Pérez, Solange Costa, João Paulo Teixeira, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level - namely oxidative stress, genomic instability and DNA damage and repair biomarkers -were revised and compared...
August 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28467438/frail-or-hale-skeletal-frailty-indices-in-medieval-london-skeletons
#11
Kathryn E Marklein, Douglas E Crews
To broaden bioarchaeological applicability of skeletal frailty indices (SFIs) and increase sample size, we propose indices with fewer biomarkers (2-11 non-metric biomarkers) and compare these reduced biomarker SFIs to the original metric/non-metric 13-biomarker SFI. From the 2-11-biomarker SFIs, we choose the index with the fewest biomarkers (6-biomarker SFI), which still maintains the statistical robusticity of a 13-biomarker SFI, and apply this index to the same Medieval monastic and nonmonastic populations, albeit with an increased sample size...
2017: PloS One
https://www.readbyqxmd.com/read/28462469/greater-yogurt-consumption-is-associated-with-increased-bone-mineral-density-and-physical-function-in-older-adults
#12
E Laird, A M Molloy, H McNulty, M Ward, K McCarroll, L Hoey, C F Hughes, C Cunningham, J J Strain, M C Casey
In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults. INTRODUCTION: The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA)...
May 1, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28444181/allogeneic-human-mesenchymal-stem-cell-infusions-for-aging-frailty
#13
Samuel Golpanian, Darcy L DiFede, Aisha Khan, Ivonne Hernandez Schulman, Ana Marie Landin, Bryon A Tompkins, Alan W Heldman, Roberto Miki, Bradley J Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Marietsy V Pujol, Moisaniel Da Fonseca, Anthony A Oliva, Geoff Green, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Pascal J Goldschmidt-Clermont, Joshua M Hare
Background: Impaired endogenous stem cell repair capacity is hypothesized to be a biologic basis of frailty. Therapies that restore regenerative capacity may therefore be beneficial. This Phase 1 study evaluated the safety and potential efficacy of intravenous, allogeneic, human mesenchymal stem cell (allo-hMSC)-based therapy in patients with aging frailty. Methods: In this nonrandomized, dose-escalation study, patients received a single intravenous infusion of allo-hMSCs: 20-million (n = 5), 100-million (n = 5), or 200-million cells (n = 5)...
April 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28424183/biomarker-calibrated-nutrient-intake-and-healthy-diet-index-associations-with-mortality-risks-among-older-and-frail-women-from-the-women-s-health-initiative
#14
Oleg Zaslavsky, Shira Zelber-Sagi, James R Hebert, Susan E Steck, Nitin Shivappa, Fred K Tabung, Michael D Wirth, Yunqi Bu, James M Shikany, Tonya Orchard, Robert B Wallace, Linda Snetselaar, Lesley F Tinker
Background: Although studies to date have confirmed the association between nutrition and frailty, the impact of dietary intake and dietary patterns on survivorship in those with frailty is yet to be examined in a well-powered cohort with validated frailty status. Moreover, previous studies were limited by measurement error from dietary self-reports.Objective: We derived biomarker-calibrated dietary energy and protein intakes to address dietary self-report error. Using these data, we then evaluated the association of mortality in older women with frailty and dietary intake and healthy diet indexes, such as the alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH) score, and the Dietary Inflammatory Index (DII)...
June 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28423084/immune-system-dysfunction-in-the-elderly
#15
Eduardo Fuentes, Manuel Fuentes, Marcelo Alarcón, Iván Palomo
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28401737/identifying-frailty-in-primary-care-a-systematic-review
#16
REVIEW
Linda Lee, Tejal Patel, Loretta M Hillier, Niraj Maulkhan, Karen Slonim, Andrew Costa
AIM: Identification of frailty in the primary care setting could be improved with the availability of easily identifiable markers of frailty. The purpose of this article was to systematically review markers for frailty or risk tools that have been validated in the ambulatory care setting. METHODS: Medline, PubMed, CIHAHL and Embase databases were searched up to March 2016 for studies on frailty markers in community-dwelling individuals 65 years or older. Studies were included for review if they were carried out in primary care or outpatient settings, used a validated definition of frailty, compared two or more markers, and used randomized controlled trial, quasi-experimental or prospective cohort designs...
April 12, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28367083/proteomics-analysis-to-identify-and-characterize-the-biomarkers-and-physical-activities-of-non-frail-and-frail-older-adults
#17
Ching-Hung Lin, Chen-Chung Liao, Chi-Huang Huang, Yu-Tang Tung, Huan-Cheng Chang, Mei-Chich Hsu, Chi-Chang Huang
Globally, the proportion of older adults is increasing. Older people face chronic conditions such as sarcopenia and functional decline, which are often associated with disability and frailty. Proteomics assay of potential serum biomarkers of frailty in older adults. Older adults were divided into non-frail and frail groups (n = 6 each; 3 males in each group) in accordance with the Chinese-Canadian Study of Health and Aging Clinical Frailty Scale. Adults were measured for grip power and the 6-min walk test for physical activity, and venous blood was sampled after adults fasted for 8 h...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28364871/oxidative-stress-and-frailty-a-systematic-review-and-synthesis-of-the-best-evidence
#18
REVIEW
Pinar Soysal, Ahmet Turan Isik, Andre F Carvalho, Brisa S Fernandes, Marco Solmi, Patricia Schofield, Nicola Veronese, Brendon Stubbs
OBJECTIVE: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to investigate potential interactions between OS and frailty. METHODS: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28329858/cystatin-c-and-the-risk-of-frailty-and-mortality-in-older-men
#19
Allyson Hart, Terri L Blackwell, Misti L Paudel, Brent C Taylor, Eric S Orwoll, Peggy M Cawthon, Kristine E Ensrud
Background: This study examines the association between cystatin C (cysC) levels and risks of progression of frailty status or death in older men. Methods: Prospective study of 2,613 men without overt frailty aged 67 years and older enrolled in the MrOS ancillary sleep study. Baseline measurements included serum cysC, serum creatinine, and frailty status. Repeat frailty status, performed an average of 3.4 years later, was assessed as an ordinal outcome of robust, intermediate stage (prefrail), frail or dead...
July 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28323342/inflammatory-markers-and-frailty-in-long-term-care-residents
#20
Gabrielle A Langmann, Subashan Perera, Mary A Ferchak, David A Nace, Neil M Resnick, Susan L Greenspan
OBJECTIVES: To determine whether proinflammatory biomarkers are associated with frailty assessed according to functional status, mobility, mental health, and falls over 24 months. DESIGN: Secondary analysis of a 2-year double-blind clinical trial for osteoporosis. SETTING: Nursing homes and assisted living facilities. PARTICIPANTS: Women aged 65 and older with osteoporosis in long-term care (LTC) (N = 178). MEASUREMENTS: Baseline serum concentrations of proinflammatory cytokines and soluble receptors (high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNFα) and its two receptors (TNFα-R1 and TNFα-R2), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL-10), functional status assessed according to activities of daily living, the Nursing Home Physical Performance Test, gait speed, cognitive status, mental health, and falls...
March 21, 2017: Journal of the American Geriatrics Society
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