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https://www.readbyqxmd.com/read/29241232/thromboelastographic-assessment-of-the-impact-of-mexiletine-on-coagulation-abnormalities-induced-by-air-or-normal-saline-intravenous-injections-in-conscious-rats
#1
Joseph L Nates, Davide Cattano, Fernanda S Costa, Jacques E Chelly, Marie-Francoise Doursout
BACKGROUND: Thromboelastography (TEG) in venous air embolism (VAE) has been poorly studied. We induced coagulation abnormalities by VAE in a rat model, assessed by TEG with and without mexiletine, a lidocaine analogue local anesthetic. METHODS: Twenty-three Sprague Dawley rats instrumented under isoflurane anesthesia and allowed to recover five days prior to the experiments were randomized into three experimental groups: 1) VAE (n = 6); 2) VAE and mexiletine (n = 9); and 3) normal saline (NS) alone (control group, n = 8)...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29241206/a-multicenter-experience-with-long-acting-somatostatin-analogues-in-patients-with-congenital-hyperinsulinism
#2
Ivo van der Steen, Mirjam E van Albada, Klaus Mohnike, Henrik Thybo Christesen, Susann Empting, Maria Salomon-Estebanez, Amalie Greve Rasmussen, Annemarie Verrijn Stuart, Annelieke A A van der Linde, Indraneel Banerjee, Annemieke M Boot
BACKGROUND/AIMS: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment. Long-acting somatostatin analogues have been used in children as off-label medication. However, the efficacy, outcomes, and adverse effect profiles of long-acting somatostatin analogues have not been described in multicentered studies. The aim of this retrospective study is to summarize the experience with long-acting somatostatin analogues in a large group of children with CHI...
December 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29241124/struvite-formation-and-decomposition-characteristics-for-ammonia-and-phosphorus-recovery-a-review-of-magnesium-ammonia-phosphate-interactions
#3
REVIEW
Berrin Tansel, Griffin Lunn, Oscar Monje
Struvite (MgNH4PO4·6H2O) forms in aqueous systems with high ammonia and phosphate concentrations. However, conditions that result into struvite formation are highly dependent on the ionic compositions, temperature, pH, and ion speciation characteristics. The primary ions involved in struvite formation have complex interactions and can form different crystals depending on the ionic levels, pH and temperature. Struvite as well as struvite analogues (with substitution of monovalent cations for NH4+ or divalent cations for Mg2+) as well as other crystals can form simultaneously and result in changes in crystal morphology during crystal growth...
December 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/29240773/polypyridylruthenium-ii-complexes-exert-anti-schistosome-activity-and-inhibit-parasite-acetylcholinesterases
#4
Madhu K Sundaraneedi, Bemnet Tedla, Ramon M Eichenberger, Luke Becker, Darren Pickering, Michael J Smout, Siji Rajan, Phurpa Wangchuk, F Richard Keene, Alex Loukas, J Grant Collins, Mark S Pearson
BACKGROUND: Schistosomiasis affects over 200 million people and there are concerns whether the current chemotherapeutic control strategy (periodic mass drug administration with praziquantel (PZQ)-the only licenced anti-schistosome compound) is sustainable, necessitating the development of new drugs. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the anti-schistosome efficacy of polypyridylruthenium(II) complexes and showed they were active against all intra-mammalian stages of S...
December 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29240714/spiro-pyrrolidine-3-3-oxindoles-and-their-indoline-analogues-as-new-5-ht6-receptor-chemotypes
#5
Ádám A Kelemen, Grzegorz Satala, Andrzej J Bojarski, György M Keserű
Synthetic derivatives of spiro[pyrrolidinyl-3,3'-oxindole] alkaloids (coerulescine analogues) were investigated as new ligands for aminergic G-protein coupled receptors (GPCRs). The chemical starting point 2'-phenylspiro[indoline-3,3'-pyrrolidin]-2-one scaffold was identified by virtual fragment screening utilizing ligand- and structure based methods. As a part of the hit-to-lead optimization a structure-activity relationship analysis was performed to explore the differently substituted 2'-phenyl-derivatives, introducing the phenylsulphonyl pharmacophore and examining the corresponding reduced spiro[pyrrolidine-3,3'-indoline] scaffold...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240703/bioactive-compounds-from-the-stems-of-clausena-lansium
#6
Jie Liu, Chuang-Jun Li, Yi-Qian Du, Li Li, Hua Sun, Nai-Hong Chen, Dong-Ming Zhang
In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the stems of C. lansium in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A-B (1-2), one new pair of phenolic enantiomers (3a, 3b), and two new monoterpenoids, clausenapene A-B (4-5), together with twelve known analogues (6-17) were isolated from the stems of C. lansium. Compounds 1-17 were obtained from C. lansium for the first time...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240689/investigating-%C3%AE-n-methylamino-l-alanine-misincorporation-in-human-cell-cultures-a-comparative-study-with-known-amino-acid-analogues
#7
Rianita van Onselen, Simoné Downing, Gabré Kemp, Tim Downing
Misincorporation of β-N-methylamino-l-alanine (BMAA) into proteins has been proposed to be a mechanism of toxicity to explain the role of BMAA in neurodegenerative disease development. However, studies have shown that all detectable BMAA can be removed from proteins by SDS-PAGE purification and that the toxicity of l-canavanine cannot be reproduced in prokaryotes or in a rat pheochromocytoma cell line, strongly indicating that the misincorporation hypothesis of BMAA should be re-investigated. The aim of this study was therefore to determine if BMAA misincorporates into proteins in cells of human origin with subsequent misincorporation-type toxicity...
December 14, 2017: Toxins
https://www.readbyqxmd.com/read/29240396/casting-a-wider-net-rational-synthesis-design-of-low-dimensional-bulk-materials
#8
Katherine A Benavides, Iain W H Oswald, Julia Y Chan
The discovery of novel magnetic and electronic properties in low-dimensional materials has led to the pursuit of hierarchical materials with specific substructures. Low-dimensional solids are highly anisotropic by nature and show promise in new quantum materials leading to exotic physical properties not realized in three-dimensional materials. We have the opportunity to extend our synthetic strategy of the flux-growth method to designing single crystalline low-dimensional materials in bulk. The goal of this Account is to highlight the synthesis and physical properties of several low-dimensional intermetallic compounds containing specific structural motifs that are linked to desirable magnetic and electrical properties...
December 14, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29240259/dissipative-particle-dynamic-simulation-experimental-assessment-of-the-impacts-of-humic-substances-on-aqueous-aggregation-and-dispersion-of-engineered-nanoparticles
#9
Zhuang Wang, Joris T K Quik, Lan Song, Marja Wouterse, Willie J G M Peijnenburg
Comprehensive experimental quantification and mapping of the aggregation and dispersion state of engineered nanoparticles (NPs) in the presence of humic substances (HS) is a great challenge. Dissipative particle dynamic (DPD) simulation was adopted to investigate the aggregation and dispersion mechanisms of NPs in the presence of a HS analogue. Twelve different types of NPs including two metal-based NPs, seven metal oxide-based NPs, and three carbon-based NPs in pure water (pH 3.0) and algae medium (pH 8.0) in the presence of a HS analogy were selected for experimental verification of the DPD simulation results...
December 14, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29240023/immediate-effects-of-transcranial-direct-current-stimulation-on-obsession-induced-anxiety-in-refractory-obsessive-compulsive-disorder-a-pilot-study
#10
Doron Todder, Adi Gershi, Zvi Perry, Zeev Kaplan, Joseph Levine, Keren Avirame
OBJECTIVE: Studies have shown that transcranial direct current stimulation (tDCS) has immediate effects on brain activity. The aim of this study was to investigate the potential use of tDCS to regulate obsession-induced anxiety immediately after symptom provocation in patients with refractory obsessive-compulsive disorder (OCD). METHODS: Twelve patients with refractory OCD received cathode, anode, and sham transcranial direct current stimulation over the medial prefrontal cortex conjugant to pharmacological treatment in a crossover design...
December 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29239799/occupational-determinants-of-successful-aging-in-older-physicians
#11
Chanaka Wijeratne, Carmelle Peisah, Joanne Earl, Georgina Luscombe
OBJECTIVES: Demographic, physical and psychological associations of successful aging (SA) have been evaluated, but occupational factors have not. Nor has SA been evaluated in a specific occupational group. The aims of this study were to examine the occupational associations of SA in older physicians, and to explore the concept of occupational SA. METHODS: Physicians aged 55+ years completed self-ratings of occupational and personal SA on a 10-point visual analogue scale (VAS; 1 being "least successful" and 10 "most successful")...
November 24, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29239525/isolation-of-sinapic-acid-from-broccoli-using-molecularly-imprinted-polymers
#12
Heba Hosny, Nesrine El Gohary, Engy Saad, Heba Handoussa, Rasha M El Nashar
A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1:4:20), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues...
December 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29239500/ethylene-epoxidation-catalyzed-by-ag-nanoparticles-located-on-ag-lsx-zeolites-formed-by-pressure-and-temperature-induced-auto-reduction
#13
Donghoon Kim, Yongmoon Lee, Yonghwi Kim, Kathleen Mingle, Jochen Lauterbach, Douglas Blom, Thomas Vogt, Yongjae Lee
Ag-exchanged LSX, a large pore low silica analogue of faujasite, was prepared and post-synthetically modified using pressure and temperature in the presence of various pore-penetrating fluids. Using high-resolution synchrotron X-ray powder and single crystal diffraction we derive structural models of the as-prepared and post-synthetically modified Ag-LSX materials. In the as-prepared Ag-LSX model we located 96 Ag+ and 245 H2O molecules distributed over seven and five distinctive sites, respectively. At 1.4(1) GPa pressure and 150ºC in ethanol the number of Ag cations within the pores of Ag-LSX are reduced by ca...
December 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29239440/the-coordination-and-photochemistry-of-copper-i-complexes-variation-of-n-n-ligands-from-imidazole-to-tetrazole
#14
Larissa Bergmann, Carolin Braun, Martin Nieger, Stefan Bräse
The prediction of coordination modes is of high importance when structure-property relationships are discussed. Herein, the coordination chemistry of copper(i) with pyridine-amines with a varying number of coordinating N-atoms, namely pyridine-benzimidazole, -triazole and -tetrazole, or their deprotonated analogues, and different phosphines was systematically studied and the photoluminescence properties of all synthesized complexes examined and related to DFT data. Each complex was characterized by single-crystal X-ray analysis and elemental analysis, and a set of prediction rules derived for the coordination chemistry of copper(i) with these ligands...
December 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29239414/efficient-synthesis-of-benzocyclotrimer-analogues-by-negishi-cross-coupling-and-intramolecular-nucleophilic-substitution
#15
Jorge Borges-González, Tomás Martín
We report a new and efficient synthetic strategy that allows access to flexible and functionalized benzocyclotrimers under mild conditions and in few steps. The Negishi cross-coupling reaction was used for the C-C bond formation, whereas intramolecular O-alkylations provided the oxepane rings.
December 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29239108/ultrasensitive-determination-of-highly-polar-trimethyl-phosphate-in-environmental-water-by-molecularly-imprinted-polymeric-fiber-headspace-solid-phase-microextraction
#16
Cuicui Cai, Pengcheng Zhang, Jiali Deng, Hongbin Zhou, Jing Cheng
A sensitive, accurate and cost effective method for the quantification of trimethyl phosphate, which is highly polar and volatile, in environmental water is presented. Trimethyl phosphate was headspace solid-phase microextracted on a molecularly imprinted polymeric fiber, and then the fiber was thermally desorbed in the gas chromatograph injector, and the compound was determined. The trimethyl phosphate imprinted polymeric fiber was prepared by copolymerization in a fused silica capillary tube and obtained by removal of the wall of fused silica capillary tube...
December 14, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29239042/special-types-of-thyroid-carcinoma
#17
REVIEW
Zubair W Baloch, Virginia A LiVolsi
This article reviews the small percentage of thyroid tumours that are not classified as classic papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. It includes subtypes of papillary thyroid carcinoma, including, tall-cell, hobnail/micropapillary, columnar cell, diffuse sclerosing and solid variants. Poorly differentiated carcinoma, high-grade carcinoma and anaplastic thyroid carcinoma are reviewed. Also discussed are entities that are unusual but need to be recognized as primary thyroid neoplasms, i...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239016/intestinal-and-hepatic-contributions-to-the-pharmacokinetic-interaction-between-gamithromycin-and-rifampicin-after-single-dose-and-multiple-dose-administration-in-healthy-foals
#18
S Berlin, S Wallstabe, E Scheuch, S Oswald, M Hasan, D Wegner, M Grube, M Venner, A Ullrich, W Siegmund
BACKGROUND: Standard treatment of foals with severe abscessing lung infection caused by Rhodococcus equi using rifampicin and a macrolide antibiotic can be compromised by extensive inhibition and/or induction of drug metabolising enzymes (e.g. CYP3A4) and transport proteins (e.g. P-glycoprotein), as has been shown for rifampicin and clarithromycin. The combination of rifampicin with the new, poorly metabolised gamithromycin, a long-acting analogue of azithromycin and tulathromycin with lower pharmacokinetic interaction potential, might be a suitable alternative...
December 14, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29238994/intestinal-p-glycoprotein-inhibitors-benzoxanthone-analogues
#19
Song Wha Chae, Jaeok Lee, Jung Hyun Park, Youngjoo Kwon, Younghwa Na, Hwa Jeong Lee
OBJECTIVES: The inhibitors of P-glycoprotein (P-gp) which limits an access of exogenous compounds in the luminal membrane of the intestine have been studied to enhance the intestinal P-gp-mediated absorption of anticancer drugs. METHODS: Inhibition of the efflux pump by synthesized benzoxanthone derivatives was investigated in vitro and in vivo. MCF-7/ADR cell line was used for cytotoxicity assay and [3 H]-daunomycin (DNM) accumulation/efflux study. Eight benzoxanthone analogues were tested for their effects on DNM cytotoxicity...
December 13, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29238967/potent-anti-inflammatory-and-pro-resolving-effects-of-anabasum-in-a-human-model-of-self-resolving-acute-inflammation
#20
Madhur P Motwani, Frances Bennett, Paul C Norris, Alexander A Maini, Marc J George, Justine Newson, Alice Henderson, Adrian J Hobbs, Mark Tepper, Barbara White, Charles N Serhan, Raymond MacAllister, Derek W Gilroy
Anabasum is a synthetic analogue of Δ8 - tetrahydrocannabinol (THC)-11-oic acid that in pre-clinical models of experimental inflammation exerts potent anti-inflammatory actions with minimal CNS cannabimimetic activity. Here we used a novel model of acute inflammation driven by i.d. UV-killed E. coli in healthy humans and found that Anabasum (5mg) exerted a potent anti-inflammatory effect equivalent to that of prednisolone in terms of inhibiting neutrophil infiltration, the hallmark of acute inflammation. These effects arose from the inhibition of the neutrophil chemoattractant LTB4 , while the inhibition of anti-phagocytic prostanoids (PGE2 , TxB2 and PGF2 α) resulted in enhanced clearance of inflammatory stimulus from the injected site...
December 14, 2017: Clinical Pharmacology and Therapeutics
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