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https://www.readbyqxmd.com/read/29677628/circulating-metabolomic-profile-can-predict-dyslipidemia-in-hiv-patients-undergoing-antiretroviral-therapy
#1
Esther Rodríguez-Gallego, Josep Gómez, Pere Domingo, Sara Ferrando-Martínez, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Miguel López-Dupla, Raúl Beltrán-Debón, Verónica Alba, Montserrat Vargas, Alfonso J Castellano, Manuel Leal, Yolanda María Pacheco, Ezequiel Ruiz-Mateos, Félix Gutiérrez, Francesc Vidal, Anna Rull
BACKGROUND AND AIMS: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. METHODS: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months...
April 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677614/aggregation-and-charging-of-sulfate-and-amidine-latex-particles-in-the-presence-of-oxyanions
#2
Takuya Sugimoto, Tianchi Cao, Istvan Szilagyi, Michal Borkovec, Gregor Trefalt
Electrophoretic mobility and time resolved light scattering are used to measure the effect on charging and aggregation of amidine and sulfate latex particles of different oxyanions namely, phosphate, arsenate, sulfate, and selenate. In the case of negatively charged sulfate latex particles oxyanions represent the coions, while they represent counterions in the case of the positively charged amidine latex. Repulsive interaction between the sulfate latex surface and the coions results in weak ion specific effects on the charging and aggregation...
April 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677098/update-treatment-for-hbv-infection-and-persistent-risk-for-hepatocellular-carcinoma-prospect-for-an-hbv-cure
#3
REVIEW
Joseph Yoo, Hie-Won Hann, Robert Coben, Mitchell Conn, Anthony J DiMarino
Since the discovery of the hepatitis B virus (HBV) by Blumberg et al. in 1965, its genome, sequence, epidemiology, and hepatocarcinogenesis have been elucidated. Globally, hepatitis B virus (HBV) is still responsible for the majority of hepatocellular carcinoma (HCC). HCC is the sixth-most common cancer in the world and the second-most common cancer death. The ultimate goal of treating HBV infection is the prevention of HCC. Fortunately, anti-HBV treatment with nucleos(t)ide analogues (NAs), which began with lamivudine in 1998, has resulted in remarkable improvements in the survival of patients with chronic hepatitis B and a reduced incidence of HCC...
April 20, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29676847/synthesis-of-a-molecularly-imprinted-polymer-on-msio-2-fe-3-o-4-for-the-selective-adsorption-of-atrazine
#4
Xin Li, Xiaoguo Ma, Renfeng Huang, Xiaowen Xie, Lihui Guo, Menyuan Zhang
Atrazine contamination of water is of considerable concern because of the potential hazard to human health. In this study, a magnetic molecularly imprinted polymer for atrazine was prepared by the surface imprinting technique using Fe3 O4 as the core, mesoporous silica as the carrier, atrazine as the template and itaconic acid as the functional monomer. The magnetic molecularly imprinted polymer was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction and vibration sample magnetometry...
April 20, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29676822/site-selective-trans-hydrostannation-of-1-3-and-1-n-diynes-application-to-the-total-synthesis-of-typhonosides-e-and-f-and-a-fluorinated-cerebroside-analogue
#5
Alois Fürstner, Xiaobin Mo, Aurelien Letort, Dragos-Adrian Rosca, Kosuge Higashida
Propargyl alcohols are privileged substrates for stereochemically unorthodox trans-hydrostannation reactions catalyzed by [Cp*RuCl]4, because an incipient hydrogen bond between the -OH group and the polarized [RuCl] unit assists substrate binding. For this very reason it is also possible to subject diyne derivatives carrying one -OH group to site-selective stannylation, even if the acetylene units are conjugated and hence electronically coupled. An unusual temperature dependence was observed in that heating tends to improve site-selectivity, whereas per-stannylation is favored when the reaction is carried out in the cold...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29676816/optimized-two-dimensional-gel-electrophoresis-in-an-alkaline-ph-range-improves-the-identification-of-intracellular-cfda-cisplatin-protein-adducts-in-ovarian-cancer-cells
#6
Sandra Kotz, Maximilian Kullmann, Ganna V Kalayda, Nadine Dyballa-Rukes, Ulrich Jaehde, Sabine Metzger
Intracellular binding of cisplatin to proteins has been associated with acquired resistance to chemotherapy. In our previous study we established an analytical method for the identification of intracellular cisplatin-binding proteins. The method used a fluorescent carboxyfluorescein-diacetate-labeled cisplatin analogue (CFDA-cisplatin), two-dimensional gel electrophoresis (2DE) and mass spectrometry, which allows detecting and identifying intracellular CFDA-cisplatin-containing protein adducts in the acidic pH range (pH 4-7)...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676156/exploring-the-ring-closing-metathesis-for-the-construction-of-the-solomonamide-macrocyclic-core-identification-of-bioactive-precursors
#7
Iván Cheng-Sánchez, Paloma Carrillo, Antonio Sánchez-Ruiz, Beatriz Martínez-Poveda, Ana R Quesada, Miguel Ángel Medina, Juan Manuel López-Romero, Francisco Sarabia
New synthetic strategies directed towards the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized systems and the olefin metathesis reaction demonstrated efficiency and validity for the construction of the macrocyclic core. The described synthetic strategies towards the solomonamides are well suited for the subsequent access to the natural products and represent flexible and diversity-oriented routes that allow for the generation of a variety of analogues via oxidative transformations...
April 20, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29675949/multielectron-transfer-based-rechargeable-energy-storage-of-two-dimensional-coordination-frameworks-with-non-innocent-ligand
#8
Keisuke Wada, Ken Sakaushi, Sono Sasaki, Hiroshi Nishihara
Metallically-conductive bis(diimino)nickel framework (NiDI), an emerging class of metal-organic framework (MOF) analogues consisting of two-dimensional (2D) coordination networks, was found to show an energy storage principle using both cation- and anion-insertion. This principle gives high energy led by a multielectron transfer reaction: its specific capacity is one of the highest among MOF-based cathode materials in rechargeable energy storage devices, with stable cycling performance up to 300 cycles. This mechanism was studied by a wide spectrum of electrochemical techniques combined with density-functional theory calculations...
April 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29675798/a-systematic-literature-review-and-network-meta-analysis-comparing-once-weekly-semaglutide-with-other-glp-1-receptor-agonists-in-patients-with-type-2-diabetes-previously-receiving-1-2-oral-anti-diabetic-drugs
#9
Michal Witkowski, Lars Wilkinson, Neil Webb, Alan Weids, Divina Glah, Hrvoje Vrazic
INTRODUCTION: Once-weekly semaglutide is a new glucagon-like peptide-1 (GLP-1) analogue administered at a 1.0 or 0.5 mg dose. As head-to-head trials assessing once-weekly semaglutide as an add-on to 1-2 oral anti-diabetic drugs (OADs) vs other GLP-1 receptor agonists (GLP-1 RAs) are limited, a network meta-analysis (NMA) was performed. The objective was to assess the relative efficacy and safety of once-weekly semaglutide vs GLP-1 RAs in patients with type 2 diabetes (T2D) inadequately controlled on 1-2 OADs...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675759/a-comparative-study-of-surgical-drain-placement-and-the-use-of-kinesiologic-tape-to-reduce-postoperative-morbidity-after-third-molar-surgery
#10
Aysenur Genc, Sirmahan Cakarer, Basak Keskin Yalcin, Beril Berivan Kilic, Sabri Cemil Isler, Cengizhan Keskin
OBJECTIVES: Our aim was to compare the effects of the surgical drain and kinesiotape applications on postoperative morbidity after mandibular third molar surgery in a split-mouth study design. MATERIALS AND METHODS: A single-centre, split-mouth study was performed in 23 patients who needed surgical removal of bilateral mandibular third molars. Each patient was treated with a drain tube on one side of the mandible and Kinesio tape (KT) on the contralateral side. RESULTS: Swelling was significantly greater in the KT group than in the drain group throughout the study period...
April 19, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29675746/cabazitaxel-is-more-active-than-first-generation-taxanes-in-abcb1-cell-lines-due-to-its-reduced-affinity-for-p-glycoprotein
#11
George E Duran, Volker Derdau, Dietmar Weitz, Nicolas Philippe, Jörg Blankenstein, Jens Atzrodt, Dorothée Sémiond, Diego A Gianolio, Sandrine Macé, Branimir I Sikic
PURPOSE: The primary aim of this study was to determine cabazitaxel's affinity for the ABCB1/P-glycoprotein (P-gp) transporter compared to first-generation taxanes. METHODS: We determined the kinetics of drug accumulation and retention using [14 C]-labeled taxanes in multidrug-resistant (MDR) cells. In addition, membrane-enriched fractions isolated from doxorubicin-selected MES-SA/Dx5 cells were used to determine sodium orthovanadate-sensitive ATPase stimulation after exposure to taxanes...
April 19, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29675259/successful-neoadjuvant-peptide-receptor-radionuclide-therapy-for-an-inoperable-pancreatic-neuroendocrine-tumour
#12
Tiago Nunes da Silva, M L F van Velthuysen, Casper H J van Eijck, Jaap J Teunissen, J Hofland, Wouter W de Herder
Non-functional pancreatic neuroendocrine tumours (NETs) can present with advanced local or distant (metastatic) disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT) using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29675240/traceless-%C3%AE-mercaptan-assisted-activation-of-valinyl-benzimidazolinones-in-peptide-ligations
#13
Yinglu Wang, Lin Han, Ning Yuan, Hanxuan Wang, Hongxing Li, Jinrong Liu, Huan Chen, Qiang Zhang, Suwei Dong
Peptidyl thioesters or their surrogates with C-terminal β-branched hydrophobic amino acid residues usually exhibit poor reactivities in ligation reactions. Thus, activation using exogenous additives is required to ensure an acceptable reaction efficiency. Herein, we report a traceless ligation at Val-Xaa sites under mild thiol additive-free reaction conditions, whereby the introduction of β-mercaptan on the C-terminal valine residue effectively activates the otherwise unreactive N -acyl-benzimidazolinone (Nbz), and enables the use of a one-pot ligation-desulfurization strategy to generate the desired peptide products...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675216/total-chemical-synthesis-of-glycocin-f-and-analogues-s-glycosylation-confers-improved-antimicrobial-activity
#14
Zaid Amso, Sean W Bisset, Sung-Hyun Yang, Paul W R Harris, Tom H Wright, Claudio D Navo, Mark L Patchett, Gillian E Norris, Margaret A Brimble
Glycocin F (GccF) is a unique diglycosylated bacteriocin peptide that possesses potent and reversible bacteriostatic activity against a range of Gram-positive bacteria. GccF is a rare example of a 'glycoactive' bacteriocin, with both the O -linked N -acetylglucosamine (GlcNAc) and the unusual S -linked GlcNAc moiety important for antibacterial activity. In this report, glycocin F was successfully prepared using a native chemical ligation strategy and folded into its native structure. The chemically synthesised glycocin appeared to be slightly more active than the recombinant material produced from Lactobacillus plantarum ...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675206/exploiting-exciton-coupling-of-ligand-radical-intervalence-charge-transfer-transitions-to-tune-nir-absorption
#15
Ryan M Clarke, Tiffany Jeen, Serena Rigo, John R Thompson, Loren G Kaake, Fabrice Thomas, Tim Storr
We detail the rational design of a series of bimetallic bis-ligand radical Ni salen complexes in which the relative orientation of the ligand radical chromophores provides a mechanism to tune the energy of intense intervalence charge transfer (IVCT) bands in the near infrared (NIR) region. Through a suite of experimental (electrochemistry, electron paramagnetic resonance spectroscopy, UV-vis-NIR spectroscopy) and theoretical (density functional theory) techniques, we demonstrate that bimetallic Ni salen complexes form bis-ligand radicals upon two-electron oxidation, whose NIR absorption energies depend on the geometry imposed in the bis-ligand radical complex...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675144/the-aromatic-dianion-metalloles
#16
REVIEW
Junnian Wei, Wen-Xiong Zhang, Zhenfeng Xi
Metalloaromatic species are unique and important both experimentally and theoretically. Significant progress has been made during the past few decades. New aromatic systems have challenged and extended the concept of aromaticity remarkably. In this perspective, recent results on the study of the dianion aromatic metalloles and their corresponding analogues are reviewed. These include the dilithio group 14 metalloles, group 13 metalloles and transition metal metalloles. X-ray crystallography has made a key contribution to the understanding of the structures...
January 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675015/cell-lysis-and-detoxification-of-cyanotoxins-using-a-novel-combination-of-microbubble-generation-and-plasma-microreactor-technology-for-ozonation
#17
Jagroop Pandhal, Anggun Siswanto, Dmitriy Kuvshinov, William B Zimmerman, Linda Lawton, Christine Edwards
There has been a steady rise in the incidences of algal blooms globally, and worryingly, there is increasing evidence that changes in the global climate are leading to a shift toward cyanobacterial blooms. Many cyanobacterial genera are harmful, producing several potent toxins, including microcystins, for which there are over 90 described analogues. There are a wide range of negative effects associated with these toxins including gastroenteritis, cytotoxicity, hepatotoxicity and neurotoxicity. Although a variety of oxidation based treatment methods have been described, ozonation and advanced oxidation are acknowledged as most effective as they readily oxidise microcystins to non-toxic degradation products...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674236/sub-lethal-ultraviolet-b-irradiation-and-poly-i-c-treatment-synergistically-induced-apoptosis-of-hacat-cells-through-nf-%C3%AE%C2%BAb-pathway
#18
Wuxiyar Otkur, Weiwei Liu, Jinda Wang, Xingfan Jia, Dianchao Huang, Fang Wang, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Ultraviolet B (UVB) irradiation exerts multiple effects on skin cells, inducing apoptosis, senescence and carcinogenesis. Toll-like receptor 3, a member of pattern recognition receptors, is reported to initiate inflammation by recognizing double-strand RNA (dsRNA) released from UVB-irradiated cells. It has not been studied, however, whether apoptosis induction in UVB irradiation is attributed to TLR3 activation. Here, we report on the pro-apoptotic role of TLR3 in UVB-irradiated epidermal cells. Poly I:C, an analogue of dsRNA that activates TLR3, was used in combination with sub-lethal UVB (4...
April 16, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29674099/anti-fouling-and-thermosensitive-ion-imprinted-nanocomposite-membranes-based-on-grapheme-oxide-and-silicon-dioxide-for-selectively-separating-europium-ions
#19
Jian Lu, Yilin Wu, Xinyu Lin, Jia Gao, Hongjun Dong, Li Chen, Yingying Qin, Liang Wang, Yongsheng Yan
The increasing amount of europium in aqueous environment from rare earth industry has become a serious environmental challenge. Significant efforts have been focused on ion-imprinting membranes (IIMs) for selective separation of ions from analogues. Based on ion-imprinting technique, we have developed Eu3+ -imprinted nanocomposite membranes (Eu-IIMs) for selectively separating Eu3+ from La3+ , Gd3+ and Sm3+ . Polydopamine (pDA) was previously synthesized on basal membranes to augment the interfacial adhesion...
April 12, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29674090/oscillatory-local-field-potentials-of-the-nucleus-accumbens-and-the-anterior-limb-of-the-internal-capsule-in-heroin-addicts
#20
Shunnan Ge, Xinyi Geng, Xuelian Wang, Nan Li, Lei Chen, Xinjing Zhang, Yongzhi Huang, Yang Li, Yukun Chen, Shouyan Wang, Guodong Gao
OBJECTIVES: The nucleus accumbens (NAc) is known to regulate the motivation and underlie addictive behaviors, and the anterior limb of the internal capsule (ALIC) is involved in several psychiatric disorders. Our study aimed to explore the functions of NAc and ALIC electrophysiologically. METHODS: The local field potentials (LFPs) of the NAc and ALIC were recorded from 7 heroin addicts treated with deep brain stimulation. Correlation analysis was made between LFP powers in various frequency bands and the subjects' neuropsychological test scores; coherence was calculated for the LFPs in NAc and ALIC...
March 30, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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