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https://www.readbyqxmd.com/read/29924985/the-long-periodicity-phase-lpp-controversy-part-i-the-influence-of-a-natural-like-ratio-of-the-cer-eos-analogue-eos-br-in-a-cer-np-ap-based-stratum-corneum-modelling-system-a-neutron-diffraction-study
#1
Thomas Schmitt, Stefan Lange, Stefan Sonnenberger, Bodo Dobner, Bruno Demé, Andreas Langner, Reinhard H H Neubert
This study used neutron diffraction to investigate a ceramide-[NP] C24/[AP] C24 /[EOS]-br C30/cholesterol/lignoceric acid (0.6: 0.3: 0.1: 0.7: 1) based stratum corneum modelling system. By adding specifically deuterated ceramides-[NP]-D3 , [AP]-D3 , and [EOS]-br-D3 , detailed information on the lamellar and the nanostructure of the system was obtained. For the short periodicity phase a natural-like lamellar repeat distance of 5.47 ± 0.02 nm was observed, similar to the [NP]/[AP] base system without the [EOS]-br...
June 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29924915/towards-sustainable-high-performance-thermoplastics-synthesis-characterization-and-enzymatic-hydrolysis-of-bisguaiacol-based-polyesters
#2
Silvio Curia, Antonino Biundo, Isabel Fischer, Verena Braunschmid, Georg M Gübitz, Joseph Stanzione
The utilization of wood-derived building blocks (xylochemicals) to replace fossil-based precursors is an attractive research subject of modern polymer science. Here, we demonstrate that bisguaiacol (BG), a lignin-derived bisphenol analogue, can be used to prepare bio-based polyesters with remarkable thermal properties. BG has been reacted with different activated diacids to investigate the effect of co-monomer structures on the physical properties of the products. Namely, derivatives of adipic acid, succinic acid and 2,5-furandicarboxylic acid were used...
June 20, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29924779/-clinical-efficacy-of-detralex-in-treatment-of-women-with-pelvic-varicose-veins
#3
R V Akhmetzianov, R A Bredikhin
Presented herein are the results of using Detralex in conservative treatment of women suffering from pelvic varicose veins. Our open prospective study included a total of 30 women with various forms of the course of the disease. All patients took Detralex prescribed at a daily dose of 1,000 mg for 60 days. Dynamic assessment of clinical manifestations of pelvic varicose veins in this cohort of patients was carried out with the help of a specialized quality-of-life questionnaire, an adapted clinical scale of determining disease severity, as well as a visual analogue scale for assessment of the main symptoms of the disease manifestations...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924604/abietane-diterpenoids-from-the-roots-of-clerodendrum-trichotomum-and-their-nitric-oxide-inhibitory-activities
#4
Hai-Jun Hu, Yue Zhou, Zhu-Zhen Han, Yan-Hong Shi, Shu-Sheng Zhang, Zheng-Tao Wang, Li Yang
Twelve new abietane diterpenoids (1-12) and 31 known analogues (13-43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1-3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC50 values of 5...
June 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29924427/to-anion-pi-or-not-to-anion-pi-the-case-of-anion-binding-to-divalent-fluorinated-pyridines-in-the-gas-phase
#5
Melanie Göth, Felix Witte, Marcel Quennet, Phillip Jungk, Gabriel Podolan, Dieter Lentz, Waldemar Hoffmann, Kevin Pagel, Hans-Ulrich Reissig, Beate Paulus, Christoph A Schalley
A series of fluorinated pyridines is investigated by ESI (tandem) mass spectrometry and quantum chemical calculations with respect to their capability to bind anions in the gas phase. The pyridines differ in valency, the degree of fluorination, the positions of the fluorine atoms, the rigidity of the spacers and the relative configuration. While the monovalent compounds did not form anion complexes, the divalent analogues exhibit anion binding even to weakly coordinating anions such as tetrafluoroborate. Three different tandem MS experiments were applied to rank the gas-phase binding energies: (i) CID experiments in an FTICR mass spectrometer, (ii) determination of the collision energy required to fragment 50 % of the mass-selected complexes, and (iii) CID of heterodimers formed from two different, competing pyridine receptors and indigo carmine, a dianion with two identical binding sites...
June 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29924010/effect-of-led-photobiomodulation-on-analgesia-during-labor-study-protocol-for-a-randomized-clinical-trial
#6
Maria Aparecida Dos Santos Traverzim, Sergio Makabe, Daniela Fátima Teixeira Silva, Christiane Pavani, Sandra Kalil Bussadori, Kristianne Santos Porta Fernandes, Lara Jansiski Motta
BACKGROUND: Labor pain is one of the most intense pains experienced by women, which leads to an increase in the number of women opting to undergo a cesarean delivery. Pharmacological and nonpharmacological analgesia methods are used to control labor pain. Epidural analgesia is the most commonly used pharmacological analgesia method. However, it may have side effects on the fetus and the mother. Light-emitting diode (LED) photobiomodulation is an effective and noninvasive alternative to pharmacological methods...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923829/independent-evolution-of-functionally-exchangeable-mitochondrial-outer-membrane-import-complexes
#7
Daniela G Vitali, Sandro Käser, Antonia Kolb, Kai S Dimmer, Andre Schneider, Doron Rapaport
Assembly and/or insertion of a subset of mitochondrial outer membrane (MOM) proteins, including subunits of the main MOM translocase, require the fungi-specific Mim1/Mim2 complex. So far it was unclear which proteins accomplish this task in other eukaryotes. Here, we show by reciprocal complementation that the MOM protein pATOM36 of trypanosomes is a functional analogue of yeast Mim1/Mim2 complex, even though these proteins show neither sequence nor topological similarity. Expression of pATOM36 rescues almost all growth, mitochondrial biogenesis, and morphology defects in yeast cells lacking Mim1 and/or Mim2...
June 20, 2018: ELife
https://www.readbyqxmd.com/read/29923689/novel-1-3-oxazine-tetrazole-hybrids-as-mushroom-tyrosinase-inhibitors-and-free-radical-scavengers-synthesis-kinetic-mechanism-and-molecular-docking-studies
#8
Rabia Qamar, Aamer Saeed, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
A variety of 5-(2H-tetrazol-5-yl)-4-thioxo-2-(substituted phenyl)-4,5-dihydro-1,3-oxazin-6-ones (3a-k) have been synthesized from 1,3-oxazine-5-carbonitriles (2a-k). The protocol represents an efficient, facile and novel route from easily available precursors to unprecedented structures that share 1,3-oxazine and tetrazole motifs of utmost value. All the synthesized compounds (3a-k) were evaluated for their inhibitory potential against mushroom tyrosinase. Results revealed that all examined 1,3-oxazine-tetrazole hybrids exhibited significant tyrosinase inhibitory activity while compound 3d having 2-bromophenyl moiety was the most potent among the series with IC50 value 0...
June 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29923688/larvicidal-study-of-tetrahydropyrimidine-scaffolds-against-anopheles-arabiensis-and-structural-insight-by-single-crystal-x-ray-studies
#9
Keshab M Bairagi, Katharigatta N Venugopala, Pradip Kumar Mondal, Raquel M Gleiser, Deepak Chopra, Daniel García, Bharti Odhav, Susanta K Nayak
A series of methyl or ethyl 4-(substitutedphenyl/pyridyl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (HPM) analogues 4a-g was synthesized and evaluated for larvicidal activity against Anopheles arabiensis. These newly synthesized compounds were characterized by spectral studies such as FT-IR, NMR (1 H and 13 C), LC-MS and elemental analysis. The conformational features and supramolecular assembly of molecules 4a, 4b and 4e were further analyzed from single crystal X-ray study. The larvicidal activity of these tetrahydropyrimidine pharmacophore series were analyzed based on their relative substituent's...
June 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29923673/unusual-microbial-mat-related-structural-diversity-2-1-billion-years-ago-and-implications-for-the-francevillian-biota
#10
Jérémie Aubineau, Abderrazak El Albani, Ernest Chi Fru, Murray Gingras, Yann Batonneau, Luis A Buatois, Claude Geffroy, Jérôme Labanowski, Claude Laforest, Laurent Lemée, Maria G Mángano, Alain Meunier, Anne-Catherine Pierson-Wickmann, Philippe Recourt, Armelle Riboulleau, Alain Trentesaux, Kurt O Konhauser
The 2.1-billion-year-old (Ga) Francevillian series in Gabon hosts some of the oldest reported macroscopic fossils of various sizes and shapes, stimulating new debates on the origin, evolution and organization of early complex life. Here, we document ten representative types of exceptionally well-preserved mat-related structures, comprising "elephant-skin" textures, putative macro-tufted microbial mats, domal buildups, flat pyritized structures, discoidal microbial colonies, horizontal mat growth patterns, wrinkle structures, "kinneyia" structures, linear patterns and nodule-like structures...
June 20, 2018: Geobiology
https://www.readbyqxmd.com/read/29923629/ecotoxicity-of-bisphenol-s-to-caenorhabditis-elegans-by-prolonged-exposure-in-comparison-with-bisphenol-a
#11
Dong Zhou
With the increasing concerns regarding the toxic effects of bisphenol A (BPA), BPA has been gradually replaced by its analogues in the industrial applications, such as bisphenol S (BPS). As comparative toxicity evaluation of bisphenol analogs is scarce, it is necessary to conduct the comparative analysis. In this study, the model animal Caenorhabditis elegans (C. elegans) was used to evaluate low-concentration BPS toxicity, and 72-h exposure from L1 larvae was conducted. Multiple indicators at the physiological, biochemical and molecular levels were tested...
June 20, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29923567/highly-luminescent-lanthanide-complexes-sensitised-by-tertiary-amide-linked-carbostyril-antennae
#12
Daniel Kovacs, Dulcie Phipps, Andreas Orthaber, K Eszter Borbas
Carbostyrils are among the most widely used sensitising antennae for luminescent lanthanides; they afford bright complexes with Eu and Tb, and can also sensitise the emissions of the less commonly used Sm, Dy, Yb and Nd. Systematic studies on the effect of structural variations on the photophysical properties and lanthanide sensitising abilities of carbostyrils can therefore have a large impact. We replaced the secondary amide linker that connects the metal binding site to the antenna with a carboxymethyl-substituted tertiary amide...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29923565/iodine-binding-with-thiophene-and-furan-based-dyes-for-dscs
#13
Alexandra Baumann, Hammad Cheema, Md Abdus Sabuj, Louis E McNamara, Yanbing Zhang, Adithya Peddapuram, Suong T Nguyen, Davita L Watkins, Nathan I Hammer, Neeraj Rai, Jared H Delcamp
Iodine binding to thiophene rings in dyes for dye-sensitized solar cells (DSCs) has been hypothesized to be performance degrading in a number of literature cases. Binding of iodine to dyes near the semiconductor surface can promote undesirable electron transfers and lower the overall efficiency of devices. Six thiophene or furan containing dye analogs were synthesized to analyze iodine binding to the dyes via Raman spectroscopy, UV-Vis studies, device performance metrics and density functional theory (DFT) based computations...
June 20, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29923483/enterocutaneous-fistula-treatment-case-report-and-review-of-the-literature
#14
REVIEW
M Assenza, D Rossi, I De Gruttola, C Ballanti
OBJECTIVE: The aim of this work is to evaluate the treatment strategies for a common major surgery complication like the enterocutaneous fistula (ECFs). Since there is not any standard treatment for this common disease and since new therapies, like NPWT and fibrin sealants, have come up a review of all their indications seemed useful. We also present two clinical cases treated in this way. PATIENTS AND METHODS: A research was made in the principle databases such as: "Cochrane", "Pubmed", "Google Scholar" and "Google" using the following Key words "enterocutaneous fistula", "fibrin glue", "VAC", "VAC treatment", "fistula", "conservative treatment", "surgery" and using the MESH Function to search similar key words and expand the research...
May 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29923433/somatostatin-analogue-induced-pancreatic-exocrine-insufficiency-in-patients-with-neuroendocrine-tumours-results-of-a-prospective-observational-study
#15
Angela Lamarca, Lynne McCallum, Christina Nuttall, Jorge Barriuso, Alison Backen, Melissa Frizziero, Rebecca Leon, Was Mansoor, Mairéad G McNamara, Richard A Hubner, Juan W Valle
Background Patients with advanced well-differentiated neuroendocrine tumours(Wd-NETs) are commonly treated with somatostatin analogues(SSAs). Some patients may develop SSA-related side effects such as pancreatic exocrine insufficiency(PEI). Methods In this single-institution, prospective, observational study, the frequency of SSA-induced PEI in 50 sequential patients with advanced Wd-NETs treated with SSAs was investigated. Toxicity was assessed monthly and faecal elastase-1 (FE1) and quality of life (QoL) were assessed 3-monthly...
June 20, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29923239/novel-wide-range-columnar-and-lamellar-photoluminescent-liquid-crystalline-lanthanides-complexes-with-mesogenic-4-pyridone-derivatives
#16
Viorel Circu, Laura F Chiriac, Iuliana Pasuk, Mihai Secu, Marin Micutz
A series of novel liquid crystals with various lanthanide ions (Eu(III), Sm(III) and Tb(III)) was designed and prepared starting from corresponding lanthanide nitrates and N-alkylated 4-pyridones derivatives with mesogenic 3,4,5-tris(alkyloxy)benzyl moieties (alkyl = hexyl, octyl, decyl, dodecyl, tetradecyl or hexadecyl). These new lanthanidomesogens were investigated for their mesogenic properties by a combination of differential scanning calorimetry (DSC), polarizing optical microscopy (POM) and temperature dependent powder X-ray diffraction (XRD)...
June 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29923110/effects-of-a-short-term-aquatic-exercise-intervention-on-symptoms-and-exercise-capacity-in-individuals-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-pilot-study
#17
Suzanne Broadbent, Sonja Coetzee, Rosalind Beavers
PURPOSE: This pilot pre-and post-intervention study investigated the effects of a short-term aquatic exercise programme on physiological outcomes, symptoms and exercise capacity in women with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). METHODS: Eleven women (54.8 ± 12.4 year) volunteered for the 5-week program; an initial 20-min aquatic exercise session then two self-paced 20-min sessions per week for 4 weeks. Pre- and post-intervention outcomes were physiological measures, 6 min Walk Test (6MWT), perceived exertion (RPE), hand grip strength, Sit-to-Stand, Sit-Reach test, Apley's shoulder test, FACIT questionnaire, and 24-h post-test tiredness and pain scores (0-10 visual analogue scale)...
June 19, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29923027/acute-intoxications-involving-%C3%AE-pyrrolidinobutiophenone-%C3%AE-pbp-results-from-the-swedish-strida-project
#18
Lisa Franzén, Matilda Bäckberg, Olof Beck, Anders Helander
INTRODUCTION: Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe intoxication and death. METHODS: Blood and/or urine samples were collected from intoxicated patients treated at Swedish hospitals that participated in the STRIDA project, a nationawide effort to address the growing problem of NPS. In patients undergoing evaluation for drug overdose, α-PBP was identified using liquid chromatography-mass spectrometry...
June 19, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29922925/two-year-efficacy-of-single-session-high-intensity-focused-ultrasound-hifu-ablation-of-benign-thyroid-nodules
#19
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
OBJECTIVES: Assessing the efficacy of single high-intensity focused ultrasound (HIFU) ablation in benign thyroid nodules beyond 12 months. METHODS: One hundred and eight patients underwent single HIFU treatment. Extent of nodule shrinkage [by volume reduction ratio (VRR)] and obstructive symptom score [by 0-10 visual analogue scale (VAS)] were evaluated for 24 months after treatment. VRR (%) was calculated based on the formula: [baseline volume - volume at visit] / [baseline volume] × 100...
June 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29922855/hyporientalin-a-an-anti-candida-peptaibol-from-a-marine-trichoderma-orientale
#20
Ines Touati, Nicolas Ruiz, Olivier Thomas, Irina S Druzhinina, Lea Atanasova, Olfa Tabbene, Salem Elkahoui, Roudaina Benzekri, Lamjed Bouslama, Yves François Pouchus, Ferid Limam
A Trichoderma orientale strain LSBA1 was isolated from the Mediterranean marine sponge Cymbaxinella damicornis. The crude extract of T. orientale mycelium showed inhibitory activity against growth of Gram-positive and Gram-negative bacteria as well as clinical isolates of Candida albicans. Purification of the anti-Candida component was performed using a combination of open silica gel-60 column and reverse phase high performance liquid chromatography. The active compound called hyporientalin A has been identified as a peptaibol analogue of longibrachin-A-II using mass spectrometry...
June 19, 2018: World Journal of Microbiology & Biotechnology
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