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Christine L Zimmer, Franziska Rinker, Christoph Höner Zu Siederdissen, Michael P Manns, Heiner Wedemeyer, Markus Cornberg, Niklas K Björkström
Background: Treatment with nucleos(t)ide analogues (NA) efficiently suppress HBV DNA but rarely leads to functional cure of chronic hepatitis B (CHB). Following NA cessation, a fraction of HBeAg-negative CHB-patients experience HBsAg loss. Cellular immune responses, including those by natural killer cells, innate lymphocytes known to respond in CHB, explaining the virological events transpiring following NA treatment cessation remain elusive. Methods: In a single-center prospective trial, 15 HBeAg-negative CHB-patients on long-term NA treatment underwent structured NA cessation and were studied longitudinally...
February 17, 2018: Journal of Infectious Diseases
Yu Dai, Amanda Li Cheng Tan, Huan Chen, Pei Shi Ong, Xiaoqiang Xiang, Jinzhu Wu, Hai-Shu Lin
Desoxyrhapontigenin (DRG, 4-methoxyresveratrol or trans-3,5-dihydroxy-4'-methoxystilbene) is a naturally occurring resveratrol (RES) derivative with a variety of biological activities. To facilitate its further medicinal exploration, a reliable LC-MS/MS method was developed and validated for the quantification of DRG in rat plasma using heavy isotope labelled RES as an internal standard. The ESI was operated in its negative ion mode while DRG and RES were determined by multiple reaction monitoring (MRM) using precursor-to-product ion transitions of m/z 241...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
Jiangbo Bai, Lingde Kong, Hongfang Zhao, Kunlun Yu, Bing Zhang, Jichun Zhang, Dehu Tian
PURPOSE: We have make use of a new method to perform carpal tunnel release (CTR) through a 1.5-2.0 cm long incision The aim of this study is to introduce this method and to compare the effectiveness and safety of this approach to the conventional one. METHODS: We included consecutive patients diagnosed with primary carpal tunnel syndrome (CTS) who had CTR from January 2015 to September 2016. A total of 85 patients were included in our study. Among them, 42 patients with mini-incision approach were enrolled in group A, and the other 43 patients with conventional approach were enrolled in group B...
February 19, 2018: International Journal of Surgery
Cesar Gonzalez, Andersson Sanchez, Jeffrey Collins, Ksenia Lisova, Jason T Lee, R Michael van Dam, M Alejandro Barbieri, Cheppail Ramachandran, Stanislaw F Wnuk
The coupling of gemcitabine with functionalized carboxylic acids using peptide coupling conditions afforded 4-N-alkanoyl analogues with a terminal alkyne or azido moiety. Reaction of 4-N-tosylgemcitabine with azidoalkyl amine provided 4-N-alkyl gemcitabine with a terminal azido group. Click reaction with silane building blocks afforded 4-N-alkanoyl or 4-N-alkyl gemcitabine analogues suitable for fluorination. RP-HPLC analysis indicated better chemical stability of 4-N-alkyl gemcitabine analogues versus 4-N-alkanoyl analogues in acidic aqueous conditions...
February 12, 2018: European Journal of Medicinal Chemistry
Charlotte Andriessen, Pia Christensen, Lone Vestergaard Nielsen, Christian Ritz, Arne Astrup, Thomas Meinert Larsen, J Alfredo Martinez, Wim H M Saris, Marleen A van Baak, Angeliki Papadaki, Marie Kunesova, Susan Jebb, John Blundell, Clare Lawton, Anne Raben
People with obesity often struggle to maintain their weight loss after a weight loss period. Furthermore, the effect of weight loss on appetite and food preferences remains unclear. Hence this study investigated the effect of weight loss on subjective appetite and food preferences in healthy, overweight and obese volunteers. A subgroup of adult participants (n = 123) from the Diet Obesity and Genes (DiOGenes) study (subgroup A) was recruited from across six European countries. Participants lost ≥8% of initial body weight during an 8-week low calorie diet (LCD)...
February 19, 2018: Appetite
Tamam El-Elimat, José Rivera-Chávez, Joanna E Burdette, Austin Czarnecki, Maram B Alhawarri, Mohammad Al-Gharaibeh, Feras Alali, Nicholas H Oberlies
Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3'-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4'-O-methyl-3,9-dihydropunctatin (8), 7,4'-O-dimethyl-8-demethoxy-3,3'-dihydroxy-3,9-dihydropunctatin (13), and 7-O-methyl-3-hyroxy-3,9-dihydropunctatin (14) were identified from a chloroform extract of the bulbs of Bellevalia flexuosa, along with 13 known analogues. The structures were determined by analysis of HRMS and NMR data, while ECD spectroscopy enabled the assignment of the absolute configurations of the new compounds 4, 8, 13 and 16...
February 19, 2018: Fitoterapia
Silviu Sabou, Hossein Mehdian, Dritan Pasku, Luca Boriani, Nasir A Quraishi
PURPOSE: Ankylosing spondylitis (AS) can result in severe cervico-thoracic kyphotic deformity (CTKD). Few studies have addressed the relationship between cervico-thoracic osteotomies in AS and health-related quality of life scores. The aim of this study is to evaluate the impact of cervico-thoracic osteotomy (CTO) on improving quality of life for patients with fixed CTKD. METHODS: A database of all patients who underwent a CTO for CTKD in patients with AS was created...
February 22, 2018: European Spine Journal
Guoliang Zhu, Fandong Kong, Yi Wang, Peng Fu, Weiming Zhu
A new hybrid polyketide, cladodionen ( 1 ), together with a new abscisic acid analogue, cladosacid ( 2 ), were isolated from the marine-derived fungus, Cladosporium sp. OUCMDZ-1635. Their structures, including the absolute configurations, were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Cladodionen ( 1 ) showed cytotoxic activities against MCF-7, HeLa, HCT-116, and HL-60 human cancer cell lines with IC50 values of 18.7, 19.1, 17...
February 22, 2018: Marine Drugs
Anindita Bora, Kiranjyoti Mohan, Simanta Doley, Swapan Kumar Dolui
Flexible energy storage devices are the need of the hour with the advent of flexible electronics. So far, flexible supercapacitors based on graphene analogues usually have low operating potential windows. To this end, two dissimilar electrode materials with complementary potential ranges are employed to obtain an optimum cell voltage of 1.8V. Low temperature organic sol-gel method is used to prepare functionalized reduced graphene oxide aerogel (rGOA): Ag nanorod functionalized rGOA acts as anode while polyaniline nanotube functionalized rGOA acts as cathode...
February 22, 2018: ACS Applied Materials & Interfaces
Kate Prichard, David Campkin, Nicholas O'Brien, Atsushi Kato, George W J Fleet, Michela I Simone
3,4,5-Trihydroxypiperidines belong to the family of 1,5-dideoxy-1,5-iminosugar natural products and are structural analogues of pentose monosaccharides in the pyranose form. The biological activities of these apparently structurally simple molecules and their N- and O-alkylated and -arylated derivatives are no less remarkable than their C-6 hydroxymethyl counterparts of the hexoses (such as 1-deoxynojirimycin, DNJ). Their biological profiles indicate that the hydroxymethyl branch is crucial to neither potency nor selectivity, with O-alkylation demonstrated to produce exquisite selectivity extending beyond glycosidase inhibition, to immunosuppressant and antibacterial activities...
February 22, 2018: Chemical Biology & Drug Design
J A Cartwright, A G Gow, E Milne, D Drummond, S Smith, I Handel, R J Mellanby
BACKGROUND: There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog. OBJECTIVES: To define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine...
February 22, 2018: Journal of Veterinary Internal Medicine
Carla Sappino, Alessandra Mari, Agnese Mantineo, Mauro Moliterno, Matteo Palagri, Chiara Tatangelo, Lorenza Suber, Paolo Bovicelli, Alessandra Ricelli, Giuliana Righi
A study aimed at the synthesis and structure optimization of new, efficient, optically active β-amino alcohol ligands with a structure suitable for immobilization on magnetite nanoparticles has been carried out. The optimized homogeneous amino alcohol catalysts 13a and 13b, the chirality of which arises from the Sharpless epoxidation of suitable allyl alcohols, were tested by employing the well-established enantioselective amino alcohol-promoted addition of diethylzinc to benzaldehyde, giving the corresponding benzyl alcohol with nearly quantitative yield and ee = 95%...
February 22, 2018: Organic & Biomolecular Chemistry
Conar R O'Neil, Stephen E Congly, M Sarah Rose, Samuel S Lee, Meredith A Borman, Carmen L Charlton, Carla Osiowy, Mark G Swain, Kelly W Burak, Carla S Coffin
INTRODUCTION: Quantitative hepatitis B surface antigen (qHBsAg) combined with HBV DNA may be useful for predicting chronic hepatitis B (CHB) activity and nucleoside analogue (NA) response. MATERIAL AND METHODS: In this retrospective cohort study we evaluated qHBsAg levels according to CHB disease phase and among patients on treatment. Random effect logistic regression analysis was used to analyze qHBsAg change with time in the NA-treated cohort. RESULTS: 545 CHB carriers [56% M, median age 48 y (IQR 38-59), 73% Asian] had qHBsAg testing...
March 1, 2018: Annals of Hepatology
Dandan Zhang, Ruolei Gu
In daily life, people often make consecutive decisions before the ultimate goal is reached (i.e., sequential decision-making). However, this kind of decision-making has been largely overlooked in the literature. The current study investigated whether behavioral preference would change during sequential decisions, and the neural processes underlying the potential changes. For this purpose, we revised the classic balloon analogue risk task and recorded the electroencephalograph (EEG) signals associated with each step of decision-making...
February 21, 2018: Human Brain Mapping
Michael A Brook
There is a strong imperative to synthesize polymers with highly controlled structures and narrow property ranges. Silicone polymers do not lend themselves to this paradigm because acids or bases lead to siloxane equilibration and loss of structure. By contrast, elegant levels of control are possible when using the Piers-Rubinsztajn reaction and analogues, in which the hydrophobic, strong Lewis acid B(C6F5)3 activates SiH groups, permitting the synthesis of precise siloxanes under mild conditions in high yield; siloxane decomposition processes are slow under these conditions...
February 21, 2018: Chemistry: a European Journal
Gun Woo Lee, Myun-Whan Ahn
PURPOSE: To compare the postoperative clinical and radiological outcomes of the SP base osteotomy versus SP splitting techniques for PD for treating LSS. METHODS: Of 139 patients who underwent PD surgery for LSS, 97 who met the study criteria were enrolled in the study. Group A comprised 53 patients who underwent SP base osteotomy, and group B included 44 patients who underwent SP splitting osteotomy. The primary study endpoint was intensity of lower back pain (LBP) and pain radiation to the lower extremities measured with the visual analogue scale (VAS)...
February 21, 2018: European Spine Journal
Leon Maser, Jan Herritsch, Robert Langer
The reactivity patterns of carbodiphosphoranes (CDPs) as ligands are much less explored than those of isoelectronic analogues. In the current manuscript, we investigate the reactivity of the carbodiphosphorane-based PCP nickel(ii) pincer complex [({dppm}2 C)NiCl]Cl (1) towards acids and bases, calculate proton affinities, analyse the bonding situation and tautomeric forms with the aim to evaluate whether CDPs can potentially act as cooperative ligands in catalysis (dppm = 1,1-bis(diphenylphosphino)methane)...
February 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Sven Stadlbauer, Carmen Steinborn, Amy Klemd, Fumihiko Hattori, Ken Ohmori, Keisuke Suzuki, Roman Huber, Philipp Wolf, Carsten Gründemann
Among the known or suspected risk factors, inflammation plays an important role in infectious and non-infectious pathways leading to cancer. Green tea polyphenols have been associated with reducing inflammation and protection against carcinogenesis, especially in prostate cancer. While most of the research in this field, so far, has focussed on epigallocatechin-3- O -gallate only, we studied epicatechin-3- O -gallate, the second most abundant green tea polyphenol with essential therapeutic potential, to obtain a more detailed understanding of its anti-tumor and anti-inflammatory action...
February 21, 2018: Planta Medica
Stephanie Cook, Katerina Kokmotou, Vicente Soto, Hazel Wright, Nicholas Fallon, Anna Thomas, Timo Giesbrecht, Matt Field, Andrej Stancak
Odours alter evaluations of concurrently presented visual stimuli, such as faces. Stimulus onset asynchrony (SOA) is known to affect evaluative priming in various sensory modalities. However, effects of SOA on odour priming of visual stimuli are not known. The present study aimed to analyse whether subjective and cortical activation changes during odour priming would vary as a function of SOA between odours and faces. Twenty-eight participants rated faces under pleasant, unpleasant, and no-odour conditions using visual analogue scales...
February 18, 2018: Neuroscience Letters
Jiaye Jin, Guanjun Wang, Mingfei Zhou
The boron carbonyl cluster cations in the form of B3(CO)n+ (n=4-6) are produced and studied by infrared photodissociation spectroscopy in the carbonyl stretching frequency region in the gas phase. Their geometric structures are determined with the aid of density functional theory calculations. The B3(CO)4+ cation is characterized to have a D2d (OC)2B=B=B(CO)2 structure and 1A1 electronic ground state with a linear boron skeleton. The B3(CO)5+ cation is determined to have a chain boron framework with C2v symmetry...
February 21, 2018: Journal of Physical Chemistry. A
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