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Michael T Shaw, Margaret Kasschau, Bryan Dobbs, Natalie Pawlak, William Pau, Kathleen Sherman, Marom Bikson, Abhishek Datta, Leigh E Charvet
The remotely supervised tDCS (RS-tDCS) protocol enables participation from home through guided and monitored self-administration of tDCS treatment while maintaining clinical standards. The current consensus regarding the efficacy of tDCS is that multiple treatment sessions are needed to observe targeted behavioral reductions in symptom burden. However, the requirement for patients to travel to clinic daily for stimulation sessions presents a major obstacle for potential participants, due to work or family obligations or limited ability to travel...
October 7, 2017: Journal of Visualized Experiments: JoVE
Giulia Cimarelli, Borbála Turcsán, Friederike Range, Zsófia Virányi
It has been suggested that the way in which owners interact with their dogs can largely vary and influence the dog-owner bond, but very few objective studies, so far, have addressed how the owner interacts with the dog. The goal of the present study was to record dog owners' interaction styles by means of objective observation and coding. The experiment included eight standardized situations in which owners of pet dogs were asked to perform specific tasks including both positive (i.e. playing, teaching a new task, showing a preference towards an object in a food searching task, greeting after separation) and potentially distressing tasks (i...
October 13, 2017: Journal of Visualized Experiments: JoVE
E Reyes-Gilabert, L-G Luque-Romero, G Bejarano-Avila, A Garcia-Palma, A Rollon-Mayordomo, P Infante-Cossio
BACKGROUND: To analyze the pre- and postoperative anxiety level in patients undergoing ambulatory oral surgery (AOS) in a primary healthcare center (PHC). MATERIAL AND METHODS: Prospective and descriptive clinical study on 45 patients who underwent AOS procedures in the dental clinic of a public PHC of Spain between April and September 2015. Anxiety analysis was carried out with pre- and postoperative anxiety-state (STAI-S), anxiety-trait (STAI-T) and dental anxiety (MDAS) questionnaires...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
V Avellaneda-Gimeno, R Figueiredo, E Valmaseda-Castellón
BACKGROUND: Third molar extraction is a very common procedure in Dentistry. The aim of this study was to evaluate the quality of life (QoL) and satisfaction of patients undergoing extraction of an upper third molar under local anesthesia. A second objective was to describe the evolution of self-reported pain measured in a visual analogue scale (VAS) in the 7 days after surgery and its relationship with pre- and intraoperative factors. MATERIAL AND METHODS: A prospective longitudinal cohort study was made...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
Haruhiko Fuwa, Mizuho Sato
Neopeltolide, an antiproliferative marine macrolide, is known to specifically inhibit complex III of the mitochondrial electron transport chain (mETC). However, details of the biological mode-of-action(s) remain largely unknown. This work demonstrates potent cytotoxic activity of synthetic neopeltolide analogue, 8,9-dehydroneopeltolide (8,9-DNP), against starved human pancreatic adenocarcinoma PANC-1 cells and human non-small cell lung adenocarcinoma A549 cells. 8,9-DNP induced rapid dissipation of the mitochondrial membrane potential and depletion of intracellular ATP level in nutrient-deprived medium...
October 20, 2017: Marine Drugs
Orlando J Silveira, Érika N Lima, Hélio Chacham
In the present work we predict, through first-principles calculations, that bilayers of the recently synthesized Ni3 [Formula: see text] [Formula: see text] and Pt3 [Formula: see text] [Formula: see text] layered materials are topological insulators upon electron doping, and that their topological insulator properties can be modulated by the application of electric fields with magnitudes achievable in devices. The electronic structures of both bilayers are characterized by spin-orbit split graphene-like bands, with gap magnitudes that are three orders of magnitude larger than graphene's...
October 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Steven Kinio, James K Mills
This paper presents the design and experimental performance of a microelectrode-based device to selectively lyse cells in a flow in a microfluidic channel. Localized cell lysis is achieved by utilizing "irreversible electroporation", in which cells are exposed to high magnitude electric pulses. Localized cell lysis in a flow has research applications and may allow for removal of harmful cells such as circulating tumor cells from blood. Due to the dependence of this technique on the magnitude of the applied electric field, lethal electric field regions can be localized in the channel by calibration of the applied voltage...
October 17, 2017: IEEE Transactions on Nanobioscience
A González-Tudela, J I Cirac
We show that the coupling of quantum emitters to a two-dimensional reservoir with a simple band structure gives rise to exotic quantum dynamics with no analogue in other scenarios and which cannot be captured by standard perturbative treatments. In particular, for a single quantum emitter with its transition frequency in the middle of the band, we predict an exponential relaxation at a rate different from that predicted by Fermi's golden rule, followed by overdamped oscillations and slow relaxation decay dynamics...
October 6, 2017: Physical Review Letters
Maria Dumitrascuta, Tanila Ben Haddou, Elena Guerrieri, Stefan M Noha, Lea Schläfer, Helmut Schmidhammer, Mariana Spetea
Position 6 of the morphinan skeleton plays a key role on the µ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1-4 on ligand-MOR interaction, signaling and antinociception. While 6-desoxo compounds 1a, 2a and 4a show similar profiles to their 6-keto counterparts, the 6-desoxo-14-benzyloxy substituted 3a displays significantly increased MOR binding and agonist potency, and a distinct binding mode than its analogue 3...
October 20, 2017: Journal of Medicinal Chemistry
Qi Zhang, Lingyan Li, Zhaohui Qiao, Chunyang Lei, Yingchun Fu, Qingji Xie, Shouzhuo Yao, Yanbin Li, Yibin Ying
A serious impetus always exists to exploit new methods to enrich the prospect of nanomaterials. Here, we report electrochemical conversion (ECC) of magnetic nanoparticles (MNPs) to electroactive Prussian blue (PB) analogues accompanying with multiple interfacial effects and its exploitation for novel label self-sacrificial biosensing strategy. The ECC method involves a high potential step to create strong acidic condition by splitting H2O to release Fe3+ from the MNPs, and then a low potential step leading to the reduction of co-existing K3Fe(CN)6 and Fe3+ to K4Fe(CN)6 and Fe2+, respectively, which react to form PB analogues...
October 20, 2017: Analytical Chemistry
Christopher J Reed, Theodor Agapie
A new series of tetranuclear Fe clusters displaying an interstitial μ4-F ligand was prepared for a comparison to previously reported μ4-O analogues. With a single nitric oxide (NO) coordinated as a reporter of small-molecule activation, the μ4-F clusters were characterized in five redox states, from Fe(II)3{FeNO}(8) to Fe(III)3{FeNO}(7), with NO stretching frequencies ranging from 1680 to 1855 cm(-1), respectively. Despite accessing more reduced states with an F(-) bridge, a two-electron reduction of the distal Fe centers is necessary for the μ4-F clusters to activate NO to the same degree as the μ4-O system; consequently, NO reactivity is observed at more positive potentials with μ4-O than μ4-F...
October 20, 2017: Inorganic Chemistry
A Barg, R Ruiz, B Hintermann
OBJECTIVE: The aim is to correct the underlying cavovarus deformity and to achieve a pain-free and stable hindfoot. INDICATIONS: Rigid neurologic, posttraumatic, congenital, and idiopathic cavovarus deformities. CONTRAINDICATIONS: General surgical or anesthesiological risks, infections, critical soft tissue conditions, neurovascular impairment of the lower extremity, noncompliance, patients with severely reduced bone quality, insulin-dependent diabetes mellitus, smoking...
October 20, 2017: Operative Orthopädie und Traumatologie
Carlos Gueto-Tettay, Luis Pelaez-Bedoya, Juan Carlos Drosos-Ramirez
BACE1 is an aspartyl protease with a very relevant role in medicinal chemistry related to Alzheimer Disease since it has demonstrated to be a promising therapeutic target for inhibition and possible control for the progress of the peptide accumulation characteristic of this pathology. The enzymatic activity of this protein is given by the aspartic dyad, Asp93 and Asp289, which can adopt several protonation states depending on the chemical nature of its inhibitors, this is, monoprotonated, diprotonated and di-deprotonated states...
October 20, 2017: Journal of Biomolecular Structure & Dynamics
K C Nicolaou, Pengxi Chen, Shugao Zhu, Quan Cai, Rohan D Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephan Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk
A streamlined total synthesis of the naturally occurring antitumor agents trioxacarcins is described, along with its application to the construction of a series of designed analogues of these complex natural products. Biological evaluation of the synthesized compounds revealed a number of highly potent, and yet structurally simpler, compounds that are effective against certain cancer cell lines, including a drug-resistant line. A novel one-step synthesis of anthraquinones and chloro anthraquinones from simple ketone precursors and phenylselenyl chloride is also described...
October 20, 2017: Journal of the American Chemical Society
Rui-Feng Bai, Guo-Zhu Su, Xiao Feng, Rui-Fei Zhang, Xu Yin, Yun-Yun Ye, Su-Yi-le Chen, Peng-Fei Tu, Xing-Yun Chai
One new lignan, named Z-pinnatifolin A, along with ten known analogues, were isolated from the stem bark of Syringa pinnatifolia by various chromatographic methods. Their structures were extensively determined on basis of MS and NMR spectroscopic data analyses, and comparison with those in literature. Among them, compounds 3,4, and 8-11 were isolated from this genus for the first time, and 5-7 were isolated from the specie for the first time. Compound 1 showed a moderate inhibition on NO production in BV-2 cells...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
P Fernández-Serrano, L Casares-Crespo, M P Viudes-de-Castro
This study was designed to develop chitosan (CS)-dextran sulphate (DS) nanoparticles containing a GnRH analogue and to study their effect on rabbit (Oryctolagus cuniculus) semen quality. Six experimental extenders were tested as follows: (control) Tris-citric acid-glucose (TCG), (1) 0.05% CS-0.05% DS (4:1), (2) 0.1% CS-0.05% DS (4:1), (3) 0.05% CS-0.05% DS (3:1), (4) 0.1% CS-0.05% DS (3:1), (5) 0.1% CS-0.05% DS (2:1). CS and DS were dissolved in TCG medium, and nanoparticles were obtained through magnetic stirring...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
Yi Luo, Zhendong Wang, Junliang Sun, Yingying Wang, Shaoqing Jin, Bin Zhang, Hongmin Sun, Weimin Yang
Synthesis of SFE type borosilciate zeolite was successfully carried out using a commercially available low-cost organic structure directing agent (OSDA) with ultra-low OSDA and water contents within a short crystallization time. Heteroatom (Al, Ti, V, or Fe) substituted SFE type zeolite analogues were also directly synthesized for the first time. The obtained Al containing zeolites exhibited promising catalytic performances in the disproportionation of isopropylnaphthalene.
October 19, 2017: Chemistry: a European Journal
Muhammad Masab, Muhammad Wasif Saif
INTRODUCTION: Metastatic neuroendocrine tumors (NETs) are associated with carcinoid syndrome that is typically characterized by diarrhea, cutaneous flushing and bronchospasm. Treatment with somatostatin analogues (SSA) improves the symptom burden but a significant proportion of patients stop responding to SSA therapy eventually. Novel agents with the potential to effectively control the symptoms are urgently needed. METHODS: This article reviews an in-depth analysis of the phase I-III clinical trials determining the clinical rationale for the use of tryptophan hydroxylase inhibitor, telotristat ethyl in patients with well-differentiated metastatic NETs and uncontrolled carcinoid syndrome...
October 19, 2017: Cancer Chemotherapy and Pharmacology
Søren O'Neill, Sofie Louise Thomsen Jaszczak, Anne Katrine Søndergaard Steffensen, Birgit Debrabant
BACKGROUND: Manual assessment of muscle strength is often graded using the ordinal Medical Research Council (MRC) scale. The scale has a number of inherent weaknesses, including poorly defined limits between grades '4' and '5' and very large differences in the span of muscle strength encompassed by each of the six grades. It is not necessarily obvious how to convert a manual muscle test finding into an MRC grade. Several modifications which include intermediate grades have been suggested to improve the MRC scale and the current study examines whether agreement improves and variation in ratings decrease, with an intermediate grade between '4' and '5', in circumstances where such a grade would seem appropriate...
2017: Chiropractic & Manual Therapies
Agnieszka Sobczak, Artur Teżyk, Joanna Szyndlarewicz, Jan Ziarniak, Piotr Świątek, Wiesław Malinka
Hydrochloride of 10-{2-hydroxy-3-[N,N-bis-(2-hydroxyethyl)amino]propyl}-2-trifluoromethylphenothiazine (Flu-A) is a analogue of neuroleptic fluphenazine. Flu-A exhibits anti-multidrug resistance, antimutagenic, proapoptopic, and cancer-chemopreventive activities in screening studies. To define identity, quality, and purity of new active substance it is necessary to develop a appropriate analytical method and to establish a degradation profile. Thus, a stability-indicating reversed-phase high-performance liquid chromatography method was developed and validated for quantitative determination of Flu-A in the presence of its degradation products generated under stress conditions...
2017: Medicinal Chemistry Research
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