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https://www.readbyqxmd.com/read/27896241/local-administration-of-tranexamic-acid-during-prostatectomy-surgery-effects-on-reducing-the-amount-of-bleeding
#1
Pejman Pourfakhr, Elham Gatavi, Shahram Gooran, Farhad Etezadi, Mohamad Reza Khajavi, Reza Pourroustaei, Reza Shariat Moharari, Atabak Najafi
BACKGROUND: One of the issues in prostatectomy surgery is bleeding. Although tranexamic acid (TRA) is an antifibrinolytic agent for reducing bleeding, controversies surround its use. OBJECTIVES: In this study, the effect of local administration of TRA on reducing bleeding during prostatectomy surgery was evaluated. METHODS: A total of 186 patients who underwent prostatectomy surgery were assessed in this clinical trial study. Patients were divided randomly into two groups...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27894366/evolution-of-host-range-in-the-follicle-mite-demodex-kutzeri
#2
Michael F Palopoli, VAN Tra, Kassey Matoin, Phuong D Mac
The sequences of four mitochondrial genes were determined for Demodex mites isolated from two distantly related species within the family Cervidae, and identified morphologically as belonging to the species Demodex kutzeri. The sequences were used to test the hypothesis that Demodex are strictly host-specific, and hence cospeciate with their hosts: (1) The estimated divergence time between mites found on elk vs humans agreed closely with a previous estimate of the time that these host species last shared a common ancestor, suggesting cospeciation of mites and hosts, at least over long evolutionary timescales...
November 29, 2016: Parasitology
https://www.readbyqxmd.com/read/27879222/an-integration-free-virus-free-rhesus-macaque-induced-pluripotent-stem-cell-line-ripsc89-from-embryonic-fibroblasts
#3
Enrique Sosa, Rachel Kim, Ernesto J Rojas, Linzi Hosohama, Jon D Hennebold, Kyle E Orwig, Amander T Clark
We generated a rhesus macaque induced pluripotent stem cell (riPSC) line, riPSC89, from rhesus embryonic fibroblasts (REFs). Fibroblasts were expanded from the skin of a rhesus macaque embryo at embryonic day 47. REFs and riPSCs had a normal male (42, XY) karyotype. The riPSC89 line was positive for markers of self-renewal including OCT4, NANOG, TRA-1-81 and SSEA4. Pluripotency was demonstrated through the generation of teratomas using transplantation into immunocompromised mice. The riPSC89 line may be a useful non-human primate resource to uncover developmental origins of disease, or used as a basic model to understand lineage specification in the primate embryo...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27879213/generation-of-hexa-deficient-hipscs-from-fibroblasts-of-a-tay-sachs-disease-patient
#4
Zhong Liu, Rui Zhao
Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD). The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27873029/induction-of-pluripotency-in-long-term-cryopreserved-human-neonatal-fibroblasts-in-feeder-free-condition
#5
Maria Csobonyeiova, Lubica Krajciova, Andreas Nicodemou, Stefan Polak, Lubos Danisovic
A novel approach for stem cell generation is the attempt to induce conversion of the adult somatic cells into pluripotent stem cells so called induced pluripotent stem cells (iPSCs) by introducing specific transcription factors. iPSCs have two essential cell characteristics, they are pluripotent and posses long term cell-renewal capacity. Additionally, iPSCs can be derived from patient-specific somatic cells, thus bypassing ethical and immunological issues. The aim of our study was to reprogram long-term cryopreserved human neonatal fibroblasts by new method using lipid nano-particle technology (Lipofectamine 3000 reagent transfection system) in combination with Epi 5 reprogramming vectors...
November 21, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27870393/sexual-modulation-of-sex-shared-neurons-and-circuits-in-caenorhabditis-elegans
#6
REVIEW
Douglas S Portman
Studies using the nematode C. elegans have provided unique insights into the development and function of sex differences in the nervous system. Enabled by the relative simplicity of this species, comprehensive studies have solved the complete cellular neuroanatomy of both sexes as well as the complete neural connectomes of the entire adult hermaphrodite and the adult male tail. This work, together with detailed behavioral studies, has revealed three aspects of sex differences in the nervous system: sex-specific neurons and circuits; circuits with sexually dimorphic synaptic connectivity; and sex differences in the physiology and functions of shared neurons and circuits...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27869903/-approccio-al-paziente-musulmano-ospedalizzato-durante-il-ramadan-considerazioni-bioetico-cliniche
#7
Antonio Leo, Donatella La Tegola, Giancarlo Logroscino, Felice Carabellese
RIASSUNTO. La multietnicità̀ porta gli operatori sanitari a dover acquisire nuovi strumenti di carattere linguistico, culturale e sociale al fine di rispondere ai bisogni di una così variegata utenza dei servizi sanitari. La causa della compresenza di diverse culture nel nostro Paese è da ricondurre ai flussi immigratori degli ultimi anni. La convivenza di individui di diversa etnia nel nostro territorio nazionale costringe i sanitari a considerare problemi antropologici, morali, religiosi e politici sottesi a popoli e culture lontane dalla nostra...
September 2016: Rivista di Psichiatria
https://www.readbyqxmd.com/read/27867768/induced-pluripotent-stem-cells-from-human-hair-follicle-keratinocytes-as-a-potential-source-for-in-vitro-hair-follicle-cloning
#8
Sheng Jye Lim, Shu Cheow Ho, Pooi Ling Mok, Kian Lee Tan, Alan H K Ong, Seng Chiew Gan
BACKGROUND: Human hair follicles are important for the renewal of new hairs and their development. The generation of induced pluripotent stem cells (iPSCs) from hair follicles is easy due to its accessibility and availability. The pluripotent cells derived from hair follicles not only have a higher tendency to re-differentiate into hair follicles, but are also more suited for growth in hair scalp tissue microenvironment. METHODS: In this study, human hair follicular keratinocytes were used to generate iPSCs, which were then further differentiated in vitro into keratinocytes...
2016: PeerJ
https://www.readbyqxmd.com/read/27865084/-cyberstalking-among-italian-nurses-a-large-multicentric-study
#9
Dania Comparcini, Valentina Simonetti, Roberto Lupo, Francesco Galli, Paul Bocij, Giancarlo Cicolini
SCOPO: Determinare la prevalenza di cyberstalking tra gli infermieri italiani e valutare il livello di ansia e depressione nelle vittime. METODO: Da aprile a settembre 2014 è stato condotto uno studio multicentrico trasversale in un campione di infermieri italiani (n=997) utilizzando il questionario "Cyberstalking" per analizzare il fenomeno del cyberstalking. Ai partecipanti, che si sono autodefinite vittime di cyberstalking, è stato chiesto anche di compilare gli strumenti "Beck Depression Inventory" e "State-Trait Anxiety Inventory" per valutare, rispettivamente, i livelli di depressione ed ansia...
July 2016: Professioni Infermieristiche
https://www.readbyqxmd.com/read/27864809/determinants-of-prostate-cancer-screening-intentions-of-young-black-men-aged-18-to-40%C3%A2-years
#10
Motolani E Ogunsanya, Carolyn M Brown, Folakemi T Odedina, Jamie C Barner, Taiwo Adedipe
INTRODUCTION: Black men are more likely to be diagnosed with prostate cancer, with higher stage and higher grade at presentation. Evidence suggests that for education in health promotion behaviors (such as screenings) in early adult years, young Black men can be better equipped to make informed decisions in later years. OBJECTIVE: Using the theory of reasoned action (TRA), we assessed the intention of young Black men to screen for prostate cancer when it is recommended and determined its correlates...
November 18, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27856824/all-trans-retinoic-acid-augments-the-histopathological-outcome-of-neuroinflammation-and-neurodegeneration-in-lupus-prone-mrl-lpr-mice
#11
Michelle H Theus, Joshua B Sparks, Xiaofeng Liao, Jingjing Ren, Xin M Luo
Recently, we demonstrated that treatment with all-trans-retinoic acid (tRA) induced a paradoxical effect on immune activation during the development of autoimmune lupus. Here, we further describe its negative effects on mediating neuroinflammation and neurodegeneration. Female MRL/lpr mice were orally administered tRA or VARA (retinol mixed with 10% tRA) from 6 to 14 weeks of age. Both treatments had a significant effect on brain weight, which correlated with histopathological evidence of focal astrogliosis, meningitis, and ventriculitis...
November 16, 2016: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/27856246/reprogramming-of-retinoblastoma-cancer-cells-into-cancer-stem-cells
#12
Fengming Yue, Kanji Hirashima, Daihachiro Tomotsune, Sakiko Takizawa-Shirasawa, Tadayuki Yokoyama, Katsunori Sasaki
Retinoblastoma is the most common intraocular malignancy in pediatric patients. It develops rapidly in the retina and can be fatal if not treated promptly. It has been proposed that a small population of cancer cells, termed cancer stem cells (CSCs), initiate tumorigenesis from immature tissue stem cells or progenitor cells. Reprogramming technology, which can convert mature cells into pluripotent stem cells (iPS), provides the possibility of transducing malignant cancer cells back to CSCs, a type of early stage of cancer...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27833126/binary-colloidal-crystals-bccs-as-a-feeder-free-system-to-generate-human-induced-pluripotent-stem-cells-hipscs
#13
Peng-Yuan Wang, Sandy Shen-Chi Hung, Helmut Thissen, Peter Kingshott, Raymond Ching-Bong Wong
Human induced pluripotent stem cells (hiPSCs) are capable of differentiating into any cell type and provide significant advances to cell therapy and regenerative medicine. However, the current protocol for hiPSC generation is relatively inefficient and often results in many partially reprogrammed colonies, which increases the cost and reduces the applicability of hiPSCs. Biophysical stimulation, in particular from tuning cell-surface interactions, can trigger specific cellular responses that could in turn promote the reprogramming process...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27831763/thyroid-patient-salivary-radioiodine-transit-and-dysfunction-assessment-using-chewing-gums
#14
Demetrios Okkalides
Radiation-induced salivary gland dysfunction is the most frequent side-effect of I-131 thyroid therapy. Here, a novel saliva sampling method with ordinary chewing gums administered to the patients at appropriate time intervals post-treatment (TIPT) was used to relate this effect to chewing gum saliva activity (CGSA) content. Saliva samples were acquired after the oral administration of prescribed I-131 activity (radioactivity administered [RA]) to 19 differentiated thyroid cancer (DTC) and 16 hyperthyroidism patients of the radioisotope unit (RIU) during 2014 and 2015...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27830687/-expression-analysis-of-a-transformer-gene-in-daphnia-pulex-after-rnai
#15
C Y Guo, P Chen, M M Zhang, J J Ning, С L Wang, D L Wang, Y L Zhao
In order to explore the importance of the transformer (tra) gene in reproductive mode switching in Daphnia pulex, we studied the effect of silencing of this gene using RNA interference (RNAi). We obtained Dptra dsRNA by constructing and using a dsRNA expression vector and transcription method in vitro. D. pulex individuals in different reproductive modes were treated by soaking in a solution of Dptra dsRNA. We then assayed the expression of the endogenous Dptra mRNA after RNAi treatment using RT-PCR and obtained the suppression ratio...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27814972/lumped-parameter-electromyogram-driven-musculoskeletal-hand-model-a-potential-platform-for-real-time-prosthesis-control
#16
Dustin L Crouch, He Huang
Simple, lumped-parameter musculoskeletal models may be more adaptable and practical for clinical real-time control applications, such as prosthesis control. In this study, we determined whether a lumped-parameter, EMG-driven musculoskeletal model with four muscles could predict wrist and metacarpophalangeal (MCP) joint flexion/extension. Forearm EMG signals and joint kinematics were collected simultaneously from 5 able-bodied (AB) subjects. For one subject with unilateral transradial amputation (TRA), joint kinematics were collected from the sound arm during bilateral mirrored motion...
October 27, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27811957/a-compact-time-reversal-emitter-receiver-based-on-a-leaky-random-cavity
#17
Trung-Dung Luong, Thomas Hies, Claus-Dieter Ohl
Time reversal acoustics (TRA) has gained widespread applications for communication and measurements. In general, a scattering medium in combination with multiple transducers is needed to achieve a sufficiently large acoustical aperture. In this paper, we report an implementation for a cost-effective and compact time reversal emitter-receiver driven by a single piezoelectric element. It is based on a leaky cavity with random 3-dimensional printed surfaces. The random surfaces greatly increase the spatio-temporal focusing quality as compared to flat surfaces and allow the focus of an acoustic beam to be steered over an angle of 41°...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807520/the-effect-of-resistance-exercise-direction-for-hip-joint-stabilization-on-lateral-abdominal-muscle-thickness
#18
Ju-Hyeon Jung, Sang-Yeol Lee
The aim of this study was to determine the effects of resistance direction in hip joint stabilization exercise on change in lateral abdominal muscle thickness in healthy adults. Twenty-six healthy adults were randomly allocated to either a hip stabilization exercise by hip straight resistance group (n=12) or a hip diagonal resistance group (n=14). The outcome measures included contraction thickness ratio in transversus abdominis (TrA), internal oblique (IO) and external oblique, and TrA lateral slide were assessed during the abdominal drawing-in maneuver by b-mode ultrasound...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27799813/local-analgesic-effect-of-tramadol-is-mediated-by-opioid-receptors-in-late-postoperative-pain-after-plantar-incision-in-rats
#19
José Oswaldo de Oliveira Junior, Milena Fernandes de Freitas, Carolina Bullara de Andrade, Marucia Chacur, Hazem Adel Ashmawi
Tramadol is a drug used to treat moderate to severe pain. It is known to present a peripheral effect, but the local mechanisms underlying its actions remain unclear. The role of peripheral opioid receptors in postoperative pain is not well understood. In the present study, we examined the peripheral opioid receptors to determine the local effect of tramadol in a plantar incision pain model. Rats were subjected to plantar incision and divided into four groups on postoperative day (POD) 1: SF_SF, 0.9% NaCl injected into the right hindpaw; SF_TraI, 0...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27790412/first-report-of-complete-sequence-of-a-blandm-13-harboring-plasmid-from-an-escherichia-coli-st5138-clinical-isolate
#20
Jingnan Lv, Xiuqin Qi, Dan Zhang, Zhou Zheng, Yuehui Chen, Yinjuan Guo, Shanshan Wang, Liang Chen, Barry N Kreiswirth, Yi-Wei Tang, Zengqiang Chen, Longhua Hu, Liangxing Wang, Fangyou Yu
Since the first report of blaNDM-1, 16 blaNDM variants have been identified among Gram-negative bacteria worldwide. Recently, a novel blaNDM variant, blaNDM-13, was identified in the chromosome of an ST101 Escherichia coli isolate from Nepal. Here we first reported plasmid-mediated blaNDM-13 in a carbapenem-resistant E. coli ST5138 clinical isolate associated with hospital-acquired urinary tract infection from China. blaNDM-13 and blaSHV-12 coexisted on the a ~54 Kb self-transferable plasmid. Compared with NDM-1, NDM-13, NDM-3, and NDM-4 had two amino acid substitutions (D95N and M154L), one amino acid substitution (D95N) and one amino acid substitutions (M154L), respectively...
2016: Frontiers in Cellular and Infection Microbiology
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