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https://www.readbyqxmd.com/read/28628251/a-network-meta-analysis-of-short-and-long-term-efficacy-of-targeted-therapy-with-single-or-double-drug-regimens-in-the-treatment-of-stage-iii-iv-malignant-melanoma-based-on-16-randomized-controlled-trials
#1
Ting Xie, Chun-Yu Huang, Xu Kang, Jia-Sheng Luo, Xiao-Min Qin, Feng Han
For the treatment of stage III/IV malignant melanoma (MM), a network meta-analysis (NMA) was conducted to compare the short and long-term efficacy of targeted therapy with single or double-drug regimens. All conducted randomized controlled trials (RCTs) searched from PubMed and Cochrane Library were included in the study for direct and indirect comparison for MM. The odds ratio (OR) and surface under the cumulative ranking curves (SUCRA) value of the targeted therapy with single or double-drug regimens for treatment of stage III/IV MM were also analyzed...
June 19, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28616576/escaping-mtor-inhibition-for-cancer-therapy-tumor-suppressor-functions-of-mtor
#2
Victor H Villar, Tra Ly Nguyen, Silvia Terés, Clément Bodineau, Raúl V Durán
A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28616563/low-rate-of-access-site-complications-after-transradial-coronary-catheterization-a-prospective-ultrasound-study
#3
Violeta Mattea, Carsten Salomon, Niels Menck, Philipp Lauten, Frank Michael Malur, Anja Schade, Frank Steinborn, Lisa Costello-Boerrigter, Axel Neumeister, Harald Lapp
BACKGROUND: Transradial artery (TRA) left heart catheterization is an increasingly used technique for both diagnostic and interventional coronary procedures. This study evaluates the incidence of access site complications in the current interventional era. METHODS AND RESULTS: A total of 507 procedures were performed under standardized conditions. Each procedure was performed using high levels of anticoagulation, hydrophilic sheaths, and short post-procedural compression times...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28612905/treatment-of-coronary-chronic-total-occlusion-by-transradial-approach-current-trends-and-expert-recommendations
#4
Leszek Bryniarski, Michał Zabojszcz, Krzysztof Leszek Bryniarski
The aim of this review is to highlight the technical details and the scientific data on percutaneous coronary interventions (PCIs) in chronic total occlusion (CTO) performed by transradial approach (TRA). Transfemoral approach (TFA) is commonly regarded as the standard for CTO PCI, but there are a growing number of CTO recanalization procedures performed by TRA. We discuss the relevant technical details to approach a CTO by transradial access, especially the compatibility of various CTO recanalization techniques with specific guiding catheter sizes...
June 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28602142/safety-and-efficacy-of-percutaneous-coronary-intervention-via-transradial-versus-transfemoral-approach-in-bypass-grafts
#5
Yuxiang Dai, Chenguang Li, Feng Zhang, Ji'e Yang, Shufu Chang, Hao Lu, Hongbo Yang, Zheyong Huang, Juying Qian, Lei Ge, Junbo Ge
We compared the efficacy and safety of the transradial approach percutaneous coronary intervention (TRA-PCI) and transfemoral approach percutaneous coronary intervention (TFA-PCI) for bypass grafts lesions. Patients (n = 184) were retrospectively enrolled. Less contrast was used during the procedure in the TRA group than in the TFA group, 201.5 (45.5) mL versus 221.5 (49.1) mL, P = .004, although fluoroscopy time was longer in the TRA group, 22.5 (6.3) minutes versus 20.3 (6.1) minutes; P = .017. The incidence of net adverse clinical events (NACEs) was lower in the TRA group than in the TFA group (3...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28601791/effect-of-operational-and-water-quality-parameters-on-conventional-ozonation-and-the-advanced-oxidation-process-o3-h2o2-kinetics-of-micropollutant-abatement-transformation-product-and-bromate-formation-in-a-surface-water
#6
Marc Bourgin, Ewa Borowska, Jakob Helbing, Juliane Hollender, Hans-Peter Kaiser, Cornelia Kienle, Christa S McArdell, Eszter Simon, Urs von Gunten
The efficiency of ozone-based processes under various conditions was studied for the treatment of a surface water (Lake Zürich water, Switzerland) spiked with 19 micropollutants (pharmaceuticals, pesticides, industrial chemical, X-ray contrast medium, sweetener) each at 1 μg L(-1). Two pilot-scale ozonation reactors (4-5 m(3) h(-1)), a 4-chamber reactor and a tubular reactor, were investigated by either conventional ozonation and/or the advanced oxidation process (AOP) O3/H2O2. The effects of selected operational parameters, such as ozone dose (0...
May 11, 2017: Water Research
https://www.readbyqxmd.com/read/28589756/evaluating-the-impact-of-method-bias-in-health-behaviour-research-a-meta-analytic-examination-of-studies-utilising-the-theories-of-reasoned-action-and-planned-behaviour
#7
Máirtín S McDermott, Rajeev Sharma
The methods employed to measure behaviour in research testing the theories of reasoned action/planned behaviour (TRA/TPB) within the context of health behaviours have the potential to significantly bias findings. One bias yet to be examined in that literature is that due to common method variance (CMV). CMV introduces a variance in scores attributable to the method used to measure a construct, rather than the construct it represents. The primary aim of this study was to evaluate the impact of method bias on the associations of health behaviours with TRA/TPB variables...
June 20, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28587369/efficacy-and-indications-of-transradial-and-transfemoral-approaches-for-peripheral-artery-stent-implantation
#8
Peng Chen, Huijie Li, Chunyu Zeng, Yuqiang Fang, Weibin Shi, Xiaoqun Zhang, Chengming Yang
The transradial approach (TRA) has become an attractive alternative to the transfemoral approach (TFA) in percutaneous coronary intervention. To date, however, these two approaches have not been systematically compared in various percutaneous peripheral artery interventions (PPAIs). In the present study 258 patients with peripheral artery disease that underwent PPAI via the TRA (n=75) or the TFA (n=183) were analyzed. Clinical factors and outcomes in these two groups were compared. The puncture time was significantly longer (P<0...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584149/different-resistance-mechanisms-for-cadazolid-and-linezolid-in-c-difficile-found-by-whole-genome-sequencing-analysis
#9
Patrick Caspers, Hans H Locher, Philippe Pfaff, Sarah Diggelmann, Georg Rueedi, Daniel Bur, Daniel Ritz
Cadazolid (CDZ) is a new antibiotic currently in clinical development for the treatment of Clostridium difficile infections. CDZ interferes with the bacterial protein synthesis machinery. The aim of the present study was to identify resistance mechanisms for CDZ and compare to linezolid (LZD) in C. difficile by whole genome sequencing (WGS) of strains generated by invitro passages and of LZD resistant clinical isolates. Clones of C. difficile 630 selected with CDZ during 46 passages had a maximally 4-fold increased CDZ MIC, while the LZD MIC of clones selected with LZD increased up to 16-fold...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28583788/thyroid-hormone-receptor-alpha-tra-tissue-expression-in-ductal-invasive-breast-cancer-a-study-combining-quantitative-immunohistochemistry-with-digital-slide-image-analysis
#10
P Charalampoudis, G Agrogiannis, K Kontzoglou, G Kouraklis, G C Sotiropoulos
BACKGROUND: In breast cancer, hormonal receptors hold promise for developing novel targeted therapies. The thyroid exerts its actions via the thyroid hormone receptors alpha and beta. The clinical significance of the expression of thyroid hormone receptors in breast cancer is unclear. MATERIAL AND METHODS: We studied thyroid hormone receptor alpha (TRa) expression in 82 samples from 41 women with ductal invasive breast cancer and no thyroid disease. We performed quantitative immunohistochemistry with digital image analysis and correlated TRa expression with clinicopathological parameters...
May 25, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28582897/reflex-mediated-dynamic-neuromuscular-stabilization-in-stroke-patients-emg-processing-and-ultrasound-imaging
#11
Hyun S Yoon, Joshua Sung H You
BACKGROUND: Postural core instability is associated with poor dynamic balance and a high risk of serious falls. Both neurodevelopmental treatment (NDT) and dynamic neuromuscular stabilization (DNS) core stabilization exercises have been used to improve core stability, but the outcomes of these treatments remain unclear. OBJECTIVE: This study was undertaken to examine the therapeutic effects of NDT and DNS core stabilization exercises on muscular activity, core stability, and core muscle thickness...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28579062/distribution-of-nonperfusion-area-on-ultra-wide-field-fluorescein-angiography-in-eyes-with-diabetic-macular-edema-dave-study
#12
Wenying Fan, Kang Wang, Khalil Ghasemi Falavarjani, Min Sagong, Akihito Uji, Michael Ip, Charles C Wykoff, David M Brown, Jano van Hemert, SriniVas R Sadda
PURPOSE: To explore the distribution of nonperfusion area (NPA) in eyes with diabetic macular edema (DME) and its relationship with the severity of DME. DESIGN: Prospective, observational case series. METHODS: Forty eyes of 29 patients with treatment-naïve DME who participated in the DAVE study (NCT01552408) were included. Ultra-wide field fluorescein angiography images were sent to the Doheny Image Reading Center, where they were montaged and corrected using stereographic projection to adjust for peripheral distortion...
June 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28567356/radial-artery-occlusion-after-transradial-coronary-catheterization
#13
REVIEW
Grigorios Avdikos, Aris Karatasakis, Andreas Tsoumeleas, Efstathios Lazaris, Antonios Ziakas, Michael Koutouzis
The transradial approach (TRA) for coronary angiography and interventions is increasingly utilized around the world. Radial artery occlusion (RAO) is the most common significant complication after transradial catheterization, with incidence varying between 1% and 10%. Although RAO is rarely accompanied by hand ischemia, it is an important complication because it prohibits future transradial access and radial artery utilization as a conduit for coronary artery bypass grafting or arteriovenous fistula formation...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28565764/evaluation-of-the-maintenance-of-stemness-viability-and-differentiation-potential-of-gingiva-derived-stem-cell-spheroids
#14
Sung-Il Lee, Youngkyung Ko, Jun-Beom Park
Gingiva-derived stem cells have been applied for tissue-engineering purposes and may be considered a favorable source of mesenchymal stem cells as harvesting stem cells from the mandible or maxilla may be performed with ease under local anesthesia. The present study was performed to fabricate stem-cell spheroids using concave microwells and to evaluate the maintenance of stemness, viability, and differentiation potential. Gingiva-derived stem cells were isolated, and the stem cells of 4×10(5) (group A) or 8×10(5) (group B) cells were seeded into polydimethylsiloxane-based, concave micromolds with 600 µm diameters...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28556806/quality-of-life-in-women-with-stage-1-stress-urinary-incontinence-after-application-of-conservative-treatment-a-randomized-trial
#15
Magdalena Ptak, Agnieszka Brodowska, Sylwester Ciećwież, Iwona Rotter
Stress urinary incontinence (SUI) influences quality of life in female patients. In this study, we used ICIQ LUTS QoL (The International Consultation Incontinence Questionnaire Lower Urinary Tract Symptoms quality of life) to determine the quality of life (QoL) in various domains in patients with stage 1 SUI. The study included 140 perimenopausal women subjected to urodynamic tests at the Department of Gynaecology, Endocrinology and Gynaecologic Oncology, Pomeranian Medical University, Police (Poland) in 2013-2015...
May 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28548627/combined-single-molecule-experimental-and-computational-approaches-for-understanding-the-unfolding-pathway-of-a-viral-translation-enhancer-that-participates-in-a-conformational-switch
#16
My-Tra Le, Wojciech K Kasprzak, Bruce A Shapiro, Anne E Simon
How plus-strand [+]RNA virus genomes transition from translation templates to replication templates is a matter of much speculation. We have previously proposed that, for Turnip crinkle virus, binding of the encoded RNA-dependent RNA polymerase (RdRp) to the 3'UTR of the [+]RNA template promotes a regional wide-spread conformational switch to an alternative structure that disassembles the cap-independent translation element (CITE) in the 3'UTR. The active 3'CITE folds into a tRNA-like T-shaped structure (TSS) that binds to 80S ribosomes and 60S subunits in the P-site...
May 26, 2017: RNA Biology
https://www.readbyqxmd.com/read/28548609/a-pilot-study-to-validate-measures-of-the-theory-of-reasoned-action-for-organ-donation-behavior
#17
Shui Hung Wong, Amy Yin Man Chow
The present study aimed at taking the first attempt in validating the measures generated based on the theory of reasoned action (TRA). A total of 211 university students participated in the study, 95 were included in the exploratory factor analysis and 116 were included in the confirmatory factor analysis. The TRA measurements were established with adequate psychometric properties, internal consistency and construct validity. Findings also suggested that attitude towards organ donation has both a cognitive and affective nature, while the subjective norm of the family seems to be important to students' views on organ donation...
May 26, 2017: Death Studies
https://www.readbyqxmd.com/read/28545044/differentiation-of-spontaneously-contracting-cardiomyocytes-from-non-virally-reprogrammed-human-amniotic-fluid-stem-cells
#18
Aaron J Velasquez-Mao, Christopher J M Tsao, Madeline N Monroe, Xavier Legras, Beatrice Bissig-Choisat, Karl-Dimiter Bissig, Rodrigo Ruano, Jeffrey G Jacot
Congenital heart defects are the most common birth defect. The limiting factor in tissue engineering repair strategies is an autologous source of functional cardiomyocytes. Amniotic fluid contains an ideal cell source for prenatal harvest and use in correction of congenital heart defects. This study aims to investigate the potential of amniotic fluid-derived stem cells (AFSC) to undergo non-viral reprogramming into induced pluripotent stem cells (iPSC) followed by growth-factor-free differentiation into functional cardiomyocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28536754/movement-amplitude-on-the-functional-re-adaptive-exercise-device-deep-spinal-muscle-activity-and-movement-control
#19
A Winnard, D Debuse, M Wilkinson, L Samson, T Weber, Nick Caplan
PURPOSE: Lumbar multifidus (LM) and transversus abdominis (TrA) show altered motor control, and LM is atrophied, in people with low-back pain (LBP). The Functional Re-adaptive Exercise Device (FRED) involves cyclical lower-limb movement against minimal resistance in an upright posture. It has been shown to recruit LM and TrA automatically, and may have potential as an intervention for non-specific LBP. However, no studies have yet investigated the effects of changes in FRED movement amplitude on the activity of these muscles...
May 23, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28533630/effects-of-hippotherapy-on-the-thickness-of-deep-abdominal-muscles-and-activity-of-daily-living-in-children-with-intellectual-disabilities
#20
JiHyun Lee, Chang-Kyo Yun
[Purpose] The purpose of this study is to investigate the effect of hippotherapy exercise on the thickness of deep abdominal muscles and daily activities of children with intellectual disabilities. [Subjects and Methods] Seven children with intellectual disabilities were treated with hippotherapy for 30 minutes twice a week for 6 weeks. The thickness of deep abdominal muscles and Functional Independence Measure (FIM) of the subjects were measured by ultrasonography before and after the experiment. [Results] There was no significant change in the thickness of the External Oblique and Internal Oblique muscles, but there was a statistically significant change in Transverse Adbominis thickness and FIM score after treatment compared to before treatment...
April 2017: Journal of Physical Therapy Science
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