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https://www.readbyqxmd.com/read/29332756/asymmetry-of-activation-of-lateral-abdominal-muscles-during-the-neurodevelopmental-traction-technique
#1
Anna Gogola, Rafał Gnat, Małgorzata Zaborowska, Dorota Dziub, Michalina Gwóźdź
OBJECTIVE: The aim of the study was to evaluate the symmetry and pattern of activation of lateral abdominal muscles (LAM) in response to neurodevelopmental traction technique. DESIGN AND PARTICIPANTS: Measurements of LAM thickness were performed in four experimental conditions: during traction with the force of 5% body weight (5% traction): 1) in neutral position, 2) in 20° posterior trunk inclination; during traction with the force of 15% body weight (15% traction): 3) in neutral position, 4) in 20° posterior trunk inclination...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332741/abdominal-and-pelvic-floor-electromyographic-analysis-during-abdominal-hypopressive-gymnastics
#2
Lucas Ithamar, Alberto Galvão de Moura Filho, Marco Aurélio Benedetti Rodrigues, Kelly Cristina Duque Cortez, Vinícius Gomes Machado, Claudia Regina Oliveira de Paiva Lima, Eduarda Moretti, Andrea Lemos
INTRODUCTION: Abdominal hypopressive gymnastics appeared as an alternative to traditional abdominal exercises to promote abdominal muscles strength without overloading the pelvic floor muscles (PFM). To determine the activation level of abdominal muscles and PFM and the posture influence in the level of activation in these muscles during abdominal hypopressive gymnastics, we used surface electromyography in young and healthy multipara women. METHODS: This is an observational study with eutrophic nulliparous women aged between 18 and 35 years, with abdominal skinfold less than or equal to 3 cm and active or irregularly active physical activity...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332735/within-day-and-between-day-reliability-of-thickness-measurements-of-abdominal-muscles-using-ultrasound-during-abdominal-hollowing-and-bracing-maneuvers
#3
Mahnaz Aboufazeli, Nima Afshar-Mohajer
Ultrasonography imaging has been used as a non-invasive method to estimate the thickness and relative activities of the abdominal muscles in patients with lower back pain (LBP). However, the statistical reliability of US thickness measurements of abdominal muscles, including transversus abdominis (TrA), internal oblique (IO) and external oblique (EO) muscles during abdominal hollowing (AH) and abdominal bracing (AB) maneuvers has not been well-investigated. This study was performed on a total of 20 female subjects (10 with LBP and 10 without LBP) in the age range of 25-55 years to assess within-day and between-day reliability of the measurements...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332031/difference-of-the-thickness-and-activation-of-trunk-muscles-during-static-stoop-lift-at-different-loads-between-subjects-with-and-without-low-back-pain
#4
Hoe-Song Yang
BACKGROUND: Patients suffering from low back pain (LBP) have been reported to alter muscle contraction strategies. OBJECTIVE: To compare activity and thickness of the trunk muscles (external oblique (EO), internal oblique (IO), transversus abdominis (TrA), and lumbar multifidus (LM)) during static stoop lift at different lifting loads between the subjects with and without LBP. METHODS: Twenty eight subjects with LBP and twenty healthy subjects were recruited...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29331223/structure-based-design-and-application-of-a-nucleotide-coenzyme-mimetic-ligand-application-to-the-affinity-purification-of-nucleotide-dependent-enzymes
#5
Marigianna Marinou, Dimitrios Platis, Farid S Ataya, Evangelia Chronopoulou, Dimitrios Vlachakis, Nikolaos E Labrou
In the present study, a structure-based approach was exploited for the in silico design of a nucleotide coenzyme mimetic ligand. The enzyme formate dehydrogenase (FDH) was employed as a model in our study. The biomimetic ligand was designed and synthesized based on a tryptamine/3-aminopropylphosphonic acid bi-substituted 1,3,5-triazine (Trz) scaffold (Tra-Trz-3APP), which potentially mimics the interactions of NAD+-FDH complex. Molecular docking studies of the biomimetic ligand predicted that it can occupy the same binding site as the natural coenzyme...
January 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29330484/single-cell-rna-sequencing-resolves-self-antigen-expression-during-mtec-development
#6
Ricardo J Miragaia, Xiuwei Zhang, Tomás Gomes, Valentine Svensson, Tomislav Ilicic, Johan Henriksson, Gozde Kar, Tapio Lönnberg
The crucial capability of T cells for discrimination between self and non-self peptides is based on negative selection of developing thymocytes by medullary thymic epithelial cells (mTECs). The mTECs purge autoreactive T cells by expression of cell-type specific genes referred to as tissue-restricted antigens (TRAs). Although the autoimmune regulator (AIRE) protein is known to promote the expression of a subset of TRAs, its mechanism of action is still not fully understood. The expression of TRAs that are not under the control of AIRE also needs further characterization...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319600/abdominal-muscle-activation-during-common-modifications-of-the-trunk-curl-up-exercise
#7
Martin Eriksson Crommert, Anna Bjerkefors, Olga Tarassova, Maria M Ekblom
The purpose of this study was to investigate effects of common modifications of trunk curl-up exercise on the involvement of the abdominal muscles, particularly the deepest muscle layer, transversus abdominis (TrA). Ten healthy females performed five different variations of the trunk curl-up at a standardized speed, varying the exercise by assuming three different arm positions and applying left and right twist. Indwelling fine-wire electromyography (EMG) electrodes were used to record from TrA, obliquus internus (OI), obliquus externus (OE) and rectus abdominis (RA) unilaterally on the right side...
January 9, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29311120/transradial-cerebral-angiography-techniques-and-outcomes
#8
Brian M Snelling, Samir Sur, Sumedh S Shah, Priyank Khandelwal, Justin Caplan, Rianna Haniff, Robert M Starke, Dileep R Yavagal, Eric C Peterson
BACKGROUND: Despite several retrospective studies analyzing the safety and efficacy of transradial access (TRA) versus transfemoral access (TFA) for cerebral angiography, this transition for neurointerventional procedures has been gradual. Nonetheless, based on our positive initial institutional experience with TRA for mechanical thrombectomy in acute ischemic stroke patients, we have started transitioning more of our cerebral angiography cases to TRA. Here we present our single institution experience...
January 8, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29306669/balloon-assisted-tracking-a-practical-solution-to-avoid-radial-access-failure-due-to-difficult-anatomical-challenges
#9
Ioannis Felekos, Rafaqat Hussain, Sundip J Patel, Antonis N Pavlidis
AIM: The balloon assisted tracking (BAT) technique is utilised to overcome various anatomical difficulties during radial procedures when standard measures such as adequate sedation, pain relief, vasodilators and use of hydrophilic guidewires, fail. The aim of this study was to evaluate the success rates of the BAT technique in overcoming anatomical difficulties during radial coronary interventional procedures. METHODS: We retrospectively reviewed 1100 consecutive patients undergoing coronary procedures from the transradial approach (TRA) between May 2015 and May 2017...
December 6, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29301646/impact-of-sex-on-comparative-outcomes-of-radial-versus-femoral-access-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-data-from-the-randomized-matrix-access-trial
#10
Giuseppe Gargiulo, Sara Ariotti, Pascal Vranckx, Sergio Leonardi, Enrico Frigoli, Nestor Ciociano, Carlo Tumscitz, Francesco Tomassini, Paolo Calabrò, Stefano Garducci, Gabriele Crimi, Giuseppe Andò, Maurizio Ferrario, Ugo Limbruno, Bernardo Cortese, Paolo Sganzerla, Alessandro Lupi, Filippo Russo, Roberto Garbo, Arturo Ausiello, Dennis Zavalloni, Gennaro Sardella, Giovanni Esposito, Andrea Santarelli, Simone Tresoldi, Marco Stefano Nazzaro, Antonio Zingarelli, Anna Sonia Petronio, Stephan Windecker, Bruno R da Costa, Marco Valgimigli
OBJECTIVES: This study sought to assess whether transradial access (TRA) compared with transfemoral access (TFA) is associated with consistent outcomes in male and female patients with acute coronary syndrome undergoing invasive management. BACKGROUND: There are limited and contrasting data about sex disparities for the safety and efficacy of TRA versus TFA for coronary intervention. METHODS: In the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) program, 8,404 patients were randomized to TRA or TFA...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29297902/-la-combinazione-di-gemcitabina-e-oxaliplatino-gemox-nel-trattamento-del-carcinoma-pancreatico-in-fase-avanzata-di-malattia-le-notizie-sulla-mia-morte-sono-state-esagerate
#11
Jacopo Giuliani, Andrea Bonetti
Riassunto. L'analisi è stata condotta al fine di valutare l'effetto sia sulla sopravvivenza globale (OS) sia sulla sopravvivenza libera da progressione di malattia (PFS) della chemioterapia di combinazione in prima linea per il carcinoma pancreatico in fase avanzata di malattia. La presente analisi è limitata agli studi randomizzati controllati (RCT) di fase III. Successivamente è stata applicata la European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) agli RCT di fase III analizzati per ricavare uno score relativo all'entità del beneficio clinico ottenuto per ciascun RCT...
December 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29297233/deficiency-of-autoimmune-regulator-impairs-the-immune-tolerance-effect-of-bone-marrow-derived-dendritic-cells-in-mice
#12
Feifei Huo, Dongbei Li, Bo Zhao, Yadong Luo, Bingjie Zhao, Xueyang Zou, Yi Li, Wei Yang
As a transcription factor, autoimmune regulator (Aire) participates in thymic negative selection and maintains immune tolerance mainly by regulating the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). Aire is also expressed in dendritic cells (DCs). DCs are professional antigen-presenting cells (APCs) that affect the differentiation of T cells toward distinct subpopulations and participate in the immune response and tolerance, thereby playing an important role in maintaining homeostasis...
January 3, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29286621/quasi-stem-cells-derived-from-human-somatic-cells-by-chemically-modified-carbon-nanotubes
#13
Jae-Hyeok Lee, Hyuk-Kwon Kwon, Hyeon-Jun Shin, Gwang-Hyeon Nam, Jae-Ho Kim, Sangdun Choi
Surface modification of micro- and nanotopography has been employed to alter the surface properties of scaffolds for controlling cell attachment, proliferation, and differentiation. This study reports a method for generating multinucleated colonies as evidenced by spherical colony formation through nanotopography-induced expression of reprogramming factors in human dermal fibroblasts. Colony formation is achieved by subjecting the cells to specific environments, such as culturing with single-walled carbon nanotubes and poly-L-lysine (PLL-SWCNTs)...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29286443/reprogramming-primary-amniotic-fluid-and-membrane-cells-to-pluripotency-in-xeno-free-conditions
#14
Jaroslav Slamecka, Javier Laurini, Troy Shirley, Simon Philipp Hoerstrup, Benedikt Weber, Laurie Owen, Steven McClellan
Autologous cell-based therapies got a step closer to reality with the introduction of induced pluripotent stem cells. Fetal stem cells, such as amniotic fluid and membrane mesenchymal stem cells, represent a unique type of undifferentiated cells with promise in tissue engineering and for reprogramming into iPSC for future pediatric interventions and stem cell banking. The protocol presented here describes an optimized procedure for extracting and culturing primary amniotic fluid and membrane mesenchymal stem cells and generating episomal induced pluripotent stem cells from these cells in fully chemically defined culture conditions utilizing human recombinant vitronectin and the E8 medium...
November 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29284100/cuspal-deflection-in-premolar-teeth-restored-with-bulk-fill-resin-based-composite-materials
#15
M M Elsharkasi, J A Platt, N B Cook, G H Yassen, B A Matis
The present study investigated the effect of three high-viscosity bulk-fill resin-based composite materials on cuspal deflection in natural teeth. Thirty-two sound maxillary premolar teeth with large slot mesio-occlusal-distal cavities were distributed into four groups (n=8). Three groups were restored with bulk-fill resin composite materials (Tetric EvoCeram Bulk Fill, Ivoclar Vivadent, Schaan, Liechtenstein; x-tra fil, VOCO, Cuxhaven, Germany; and SonicFill, Kerr, Orange, CA, USA) in a single 4-mm increment...
January 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29280416/qtl-mapping-of-multiple-independent-loci-for-resistance-to-fusarium-oxysporum-f-sp-vasinfectum-races-1-and-4-in-an-interspecific-cotton-population
#16
Congli Wang, Mauricio Ulloa, Tra Duong, Philip A Roberts
Fusarium wilt, caused by the soil-borne fungal pathogen Fusarium oxysporum f. sp. vasinfectum (FOV), is a vascular disease of cotton (Gossypium spp.). FOV race 1 (FOV1) causes major plant injury and yield loss in G. hirsutum cultivars with co-infection with root-knot nematode (Meloidogyne incognita), while FOV race 4 (FOV4) causes plant damage without nematode co-infection in G. hirsutum and in G. barbadense cultivars . QTL analysis of the interspecific cross G. barbadense Pima S-7 × G. hirsutum Acala NemX revealed separate multiple loci determining resistance to FOV1 and FOV4, confirming that race-specificity occurs in FOV...
December 27, 2017: Phytopathology
https://www.readbyqxmd.com/read/29279377/identification-of-fusion-genes-and-characterization-of-transcriptome-features-in-t-cell-acute-lymphoblastic-leukemia
#17
Bing Chen, Lu Jiang, Meng-Ling Zhong, Jian-Feng Li, Ben-Shang Li, Li-Jun Peng, Yu-Ting Dai, Bo-Wen Cui, Tian-Qi Yan, Wei-Na Zhang, Xiang-Qin Weng, Yin-Yin Xie, Jing Lu, Rui-Bao Ren, Su-Ning Chen, Jian-Da Hu, De-Pei Wu, Zhu Chen, Jing-Yan Tang, Jin-Yan Huang, Jian-Qing Mi, Sai-Juan Chen
T-cell acute lymphoblastic leukemia (T-ALL) is a clonal malignancy of immature T cells. Recently, the next-generation sequencing approach has allowed systematic identification of molecular features in pediatric T-ALL. Here, by performing RNA-sequencing and other genomewide analysis, we investigated the genomic landscape in 61 adult and 69 pediatric T-ALL cases. Thirty-six distinct gene fusion transcripts were identified, with SET-NUP214 being highly related to adult cases. Among 18 previously unknown fusions, ZBTB16-ABL1, TRA-SALL2, and involvement of NKX2-1 were recurrent events...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29274707/high-mybl2-expression-and-transcription-regulatory-activity-is-associated-with-poor-overall-survival-in-patients-with-hepatocellular-carcinoma
#18
Z Guan, W Cheng, D Huang, A Wei
PURPOSE: In this study, we aimed to assess the association between MYBL2 expression/transcription regulatory activity (TRA) and overall survival (OS) in patients with primary hepatocellular carcinoma (HCC) and to explore the factors related to B-Myb TRA. MATERIALS AND METHODS: Bioinformatic analysis was performed based on data from the cancer genome atlas-liver hepatocellular carcinoma (TCGA-LIHC) and the human protein atlas (HPA). RESULTS: The death group in TCGA-LIHC had significantly higher MYBL2 RNA and exon expression than the censor group...
December 20, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29259004/a-transgenic-dual-luciferase-reporter-mouse-for-longitudinal-and-functional-monitoring-of-t-cells-in-vivo
#19
Martin Szyska, Stefanie Herda, Stefanie Althoff, Andreas Heimann, Josefine Russ, Daniele D'Abundo, Tra My Dang, Isabell Durieux, Bernd Dörken, Thomas Blankenstein, Il-Kang Na
Adoptive T-cell therapy (ATT) efficacy is limited when targeting large solid tumors. The evaluation of ATT outcomes using accessory treatment would greatly benefit from an in vivo monitoring tool, allowing the detection of functional parameters of transferred T cells. Here, we generated transgenic bioluminescence imaging of T cells (BLITC) mice expressing an NFAT-dependent click-beetle luciferase and a constitutive Renilla luciferase, which supports concomitant in vivo analysis of migration and activation of T cells...
December 19, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29250542/comparative-transcriptome-analysis-reveals-related-regulatory-mechanisms-of-androgenic-gland-in-eriocheir-sinensis
#20
Chunpeng Fu, Qifan Zeng, Fajun Li, Huicui Wang, Jian Sun, Hui Wang
Chinese mitten crab (Eriocheir sinensis) is one of the most commercially important aquaculture species in China. The androgenic gland (AG) of crustaceans plays pivotal roles in the regulation of male differentiation and in maintaining the male sexual characteristics. In order to reveal related mechanisms in AG, we compared transcriptomes of AG between proliferation and secretion phase. A total of 72,000 unigenes and 4,027 differentially expressed genes were obtained. Gene ontology enrichment analysis indicated that biological processes and metabolic pathways related to protein synthesis and secretion such as transcription, translation, and signal transduction were significantly enriched...
2017: BioMed Research International
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