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https://www.readbyqxmd.com/read/28936294/microtensile-bond-strength-of-bulk-fill-restorative-composites-to-dentin
#1
Jyothi Mandava, Divya-Prasanna Vegesna, Ravichandra Ravi, Mohan-Rao Boddeda, Lakshman-Varma Uppalapati, M D Ghazanfaruddin
BACKGROUND: To facilitate the easier placement of direct resin composite in deeper cavities, bulk fill composites have been introduced. The Mechanical stability of fillings in stress bearing areas restored with bulk-fill resin composites is still open to question, since long term clinical studies are not available so far. Thus, the objective of the study was to evaluate and compare the microtensile bond strength of three bulk-fill restorative composites with a nanohybrid composite. MATERIAL AND METHODS: Class I cavities were prepared on sixty extracted mandibular molars...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28935549/mini-pterional-and-supraorbital-keyhole-craniotomies-for-ruptured-anterior-circulation-aneurysms-experience-at-a-single-center
#2
Hoanh Tra, Trong Huynh, Ba Nguyen
A keyhole craniotomy is a type of pterional craniotomy that involves a minimally invasive approach for the treatment of cerebral aneurysms. Currently, the mini-pterional keyhole craniotomy (MPKC) and supraorbital keyhole craniotomy (SOKC) procedures are frequently performed. We evaluated the feasibility and safety of SOKCs and MPKCs for the clipping of ruptured intracranial aneurysms in the anterior cerebral circulation as an alternative to the pterional approach in a consecutive series of 25 patients. The rate of intraoperative aneurysmal rupture was 8% (2/25), and all ruptures were safely controlled...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28935264/a-potent-neuromedin-u-receptor-2-selective-alkylated-peptide
#3
Naoki Nishizawa, Yoko Kanematsu-Yamaki, Masaaki Funata, Hiroaki Nagai, Ayako Shimizu, Hisashi Fujita, Junichi Sakamoto, Shiro Takekawa, Taiji Asami
Neuromedin U (NMU) mediates various physiological functions via NMUR1 and NMUR2 receptors. NMUR2 has been considered a promising treatment option for diabetes and obesity. Although NMU-8, a shorter peptide, has potent agonist activity for both receptors, it is metabolically unstable. Therefore, NMU-8 analogs modified with long-chain alkyl moieties via a linker were synthesized. An octadecanoyl analog (17) with amino acid substitutions [αMePhe(19), Nle(21), and Arg(Me)(24)] and a linker [Tra-γGlu-PEG(2)] dramatically increased NMUR2 selectivity, with retention of high agonist activity...
September 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28934436/insights-into-onchocerca-volvulus-population-biology-through-multilocus-immunophenotyping
#4
Carmelle T Norice-Tra, José Ribeiro, Sasisekhar Bennuru, Michael P Fay, Rahul Tyagi, Makedonka Mitreva, Thomas B Nutman
We have developed a serologically based immunophenotyping approach to study Onchocerca volvulus (Ov) population diversity. Using genomic sequence data and polymerase chain reaction-based genotyping, we identified nonsynonymous single-nucleotide polymorphisms (SNPs) in the genes of 16 major immunogenic Ov proteins: Ov-CHI-1/Ov-CHI-2, Ov16, Ov-FAR-1, Ov-CPI-1, Ov-B20, Ov-ASP-1, Ov-TMY-1, OvSOD1, OvGST1, Ov-CAL-1, M3/M4, Ov-RAL-1, Ov-RAL-2, Ov-ALT-1, Ov-FBA-1, and Ov-B8. We assessed the immunoreactivity of onchocerciasis patient sera (n = 152) from the Americas, West Africa, Central Africa, and East Africa against peptides derived from 10 of these proteins containing SNPs...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28932928/a-phase-i-study-to-assess-the-mass-balance-excretion-and-pharmacokinetics-of-14-c-ixazomib-an-oral-proteasome-inhibitor-in-patients-with-advanced-solid-tumors
#5
Neeraj Gupta, Steven Zhang, Sandeepraj Pusalkar, Mihaela Plesescu, Swapan Chowdhury, Michael J Hanley, Bingxia Wang, Cindy Xia, Xiaoquan Zhang, Karthik Venkatakrishnan, Dale R Shepard
This two-part, phase I study evaluated the mass balance, excretion, pharmacokinetics (PK), and safety of ixazomib in patients with advanced solid tumors. In Part A of the study, patients received a single 4.1 mg oral solution dose of [(14)C]-ixazomib containing ~500 nCi total radioactivity (TRA), followed by non-radiolabeled ixazomib (4 mg capsule) on days 14 and 21 of the 35-day PK cycle. Patients were confined to the clinic for the first 168 h post dose and returned for 24 h overnight clinic visits on days 14, 21, 28, and 35...
September 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28931471/endovascular-treatment-of-iliac-and-common-femoral-arteries-disease-by-the-transradial-access-a-prospective-feasibility-study
#6
Roberto Lorenzoni, Cristiano Lisi, Giulia Lorenzoni, Laura Tessandori, Francesco Bovenzi
AIM: To report feasibility and safety of endovascular interventions on iliac and common femoral arteries, using the transradial access (TRA). METHODS: 100 consecutive patients (19 women; mean age 71, range 37-90years) with critical limb ischemia (30%) or claudication, and TASC A-D lesions in iliac or common femoral arteries, were prospectively enrolled, from January 2013 to June 2015, to be treated via the TRA. Exclusion criteria included no palpable radial arteries (RA) and the presence of a fistula for hemodialysis...
August 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28931159/isolation-and-molecular-characterization-of-the-transformer-gene-from-bactrocera-cucurbitae-diptera-tephritidae
#7
Ya Luo, Santao Zhao, Jiahui Li, Peizheng Li, Rihui Yan
transformer (tra) is a switch gene of sex determination in many insects, particularly in Dipterans. However, the sex determination pathway in Bactrocera cucurbitae (Coquillett), a very destructive pest on earth, remains largely uncharacterized. In this study, we have isolated and characterized one female-specific and two male-specific transcripts of the tra gene (Bcutra) of B. cucurbitae. The genomic structure of Bcutra has been determined and the presence of multiple conserved Transformer (TRA)/TRA-2 binding sites in Bcutra has been found...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28927841/maternal-provision-of-transformer-2-is-required-for-female-development-and-embryo-viability-in-the-wasp-nasonia-vitripennis
#8
Elzemiek Geuverink, Anna H Rensink, Inge Rondeel, Leo W Beukeboom, Louis van de Zande, Eveline C Verhulst
In insect sex determination a primary signal starts the genetic sex determination cascade that, in most insect orders, is subsequently transduced down the cascade by a transformer (tra) ortholog. Only a female-specifically spliced tra mRNA yields a functional TRA-protein that forms a complex with TRA2, encoded by a transformer-2 (tra2) ortholog, to act as a sex specific splicing regulator of the downstream transcription factors doublesex (dsx) and fruitless (fru). Here, we identify the tra2 ortholog of the haplodiploid parasitoid wasp N...
September 16, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28926342/recent-trends-in-the-industrial-use-and-emission-of-known-and-suspected-carcinogens-in-ontario-canada
#9
Catherine E Slavik, Sheila Kalenge, Paul A Demers
BACKGROUND: In 2010, Ontario, Canada's most populous province, implemented its Toxics Reduction Act, Ontario Regulation 455/09 (TRA), which requires four major manufacturing and mineral processing industry groups that already report releases of pollutants federally to the National Pollutant Release Inventory to additionally track, account and report their use and creation. The TRA was modeled after the Massachusetts Toxics Use Reduction Act of 1989, which has been very successful and reported significant reduction in toxic use and carcinogen release...
September 19, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28901347/-soppressione-virologica-di-hbv-e-sviluppo-di-hcc-descrizione-di-un-caso-clinico-seguito-per-15-anni
#10
Tullio Prestileo, Francesco Di Lorenzo, Adriana Sanfilippo, Claudia Imburgia, Giuseppe Cabibbo, Salvatore Corrao
Riassunto. Tra le persone infette da HIV in tutto il mondo, tra i 2 e i 4 milioni presentano coinfezione da HBV. Questo caso clinico descrive i 15 anni di malattia di un paziente coinfettato da HBV-HIV, che ha sviluppato HCC nonostante la piena aderenza ai trattamenti e la completa soppressione virale. Nostro obiettivo è segnalare agli infettivologi il possibile sviluppo di HCC indipendentemente, nonostante l'adesione alle cure e la completa soppressione virale.
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28900715/radial-versus-femoral-access-site-for-percutaneous-coronary-intervention-in-patients-suffering-acute-myocardial-infarction-a%C3%A2-randomized-prospective-multicenter-trial
#11
Christiana Schernthaner, Matthias Hammerer, Stefan Harb, Matthias Heigert, Kurt Hoellinger, Elisabeth Lassnig, Edwin Maurer, Jochen Schuler, Peter Siostrzonek, Hanno Ulmer, Andreas Winter, Johann Altenberger
BACKGROUND: Transradial access (TRA) in percutaneous coronary intervention (PCI) is a widely used standard technique with lower complication rates compared to transfemoral access (TFA). The aim of this study was to evaluate the impact of TRA versus TFA for PCI on clinically significant vascular access complications in the setting of acute myocardial infarction (AMI). METHODS: This multicenter study randomly assigned 250 patients in a 1:1 fashion (TRA vs. TFA) admitted with or without ST-segment elevation AMI undergoing immediate PCI...
September 12, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28900566/transversus-abdominis-elasticity-during-various-exercises-a-shear-wave-ultrasound-elastography-study
#12
Kuniaki Hirayama, Ryota Akagi, Yuki Moniwa, Junichi Okada, Hideyuki Takahashi
BACKGROUND: Although the transversus abdominis (TrA) is considered to play a significant role in maintaining trunk stability, there is little information regarding the type of exercise that best facilitates the development of tension in the TrA. Muscle elasticity shows a strong association with muscle tension. Shear wave ultrasound elastography provides a means by which the tension of TrA can be noninvasively estimated, by quantifying it's elasticity. PURPOSE: The purpose of this study was to examine the TrA elasticity during several exercises as measured by shear wave ultrasound elastography, and to determine which of the studied exercises demonstrated the greatest tension...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28898747/contraction-of-the-transverse-abdominal-muscle-in-pelvic-girdle-pain-is-enhanced-by-pain-provocation-during-the-task
#13
Jan M Mens, Annelies Pool-Goudzwaard
BACKGROUND: Understanding of the pathogenesis of pain in the lumbopelvic region remains a challenge. It is suggested that lumbopelvic pain is related to decreased contraction of the transverse abdominal muscles (TrA). OBJECTIVE: To investigate how pain provoked by a task influences TrA contraction during that task. DESIGN: A case-control cross-sectional study. METHOD: We recruited 40 non-pregnant women with persistent pregnancy-related posterior pelvic girdle pain (PGP) and 33 parous women (healthy controls) without PGP...
September 6, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28898112/functional-odontoblastic-like-cells-derived-from-human-ipscs
#14
H Xie, N Dubey, W Shim, C J A Ramachandra, K S Min, T Cao, V Rosa
The induced pluripotent stem cells (iPSCs) have an intrinsic capability for indefinite self-renewal and large-scale expansion and can differentiate into all types of cells. Here, we tested the potential of iPSCs from dental pulp stem cells (DPSCs) to differentiate into functional odontoblasts. DPSCs were reprogrammed into iPSCs via electroporation of reprogramming factors OCT-4, SOX2, KLF4, LIN28, and L-MYC. The iPSCs presented overexpression of the reprogramming genes and high protein expressions of alkaline phosphatase, OCT4, and TRA-1-60 in vitro and generated tissues from 3 germ layers in vivo...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28891005/evaluation-of-the-internal-oblique-external-oblique-and-transversus-abdominalis-muscles-in-patients-with-ankylosing-spondylitis-an-ultrasonographic-study
#15
Ahmet Üşen, Banu Kuran, Figen Yılmaz, Neşe Aksu, Cem Erçalık
The objectives of the study are to compare abdominal muscle thickness in ankylosing spondylitis (AS) patients with healthy subjects and determine the factors affecting these muscle thickness. Thirty-five male patients with a previous diagnosis of AS according to the Modified New York criteria and a control group consisting of 35 healthy male individuals were included in this cross-sectional and case-control study. Thicknesses of the internal oblique (IO), external oblique (EO), and transversus abdominalis (TrA) muscles were measured with ultrasound (US)...
September 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28890792/multicentre-analysis-of-current-st-elevation-myocardial-infarction-acute-care-pathways
#16
Joppe Tra, Carolien de Blok, Ineke van der Wulp, Martine C de Bruijne, Cordula Wagner
BACKGROUND: Rapid reperfusion with percutaneous coronary intervention (PCI) is vital for patients with ST segment elevation myocardial infarction (STEMI). However, the guideline-recommended time targets are regularly exceeded. The goal of this study was to gain insight into how Dutch PCI centres try to achieve these time targets by comparing their care processes with one another and with the European guideline-recommended process. In addition, accelerating factors perceived by care providers were identified...
2017: Open Heart
https://www.readbyqxmd.com/read/28876160/abdominal-draw-in-maneuver-combined-with-simulated-weight-bearing-increases-transversus-abdominis-and-internal-oblique-thickness
#17
Jeong-Soo Kim, Cynn-Heon Seok, Hye-Seon Jeon
The abdominal draw-in maneuver (ADIM) is a method commonly used to reestablish neuromuscular control of the deep spine muscles among individuals with musculoskeletal problems. The purpose of this study was to evaluate the effect of ADIM combined with simulated weight-bearing (SWB) activities in the facilitation of the deep spine muscles. The subjects were 30 young healthy individuals. Ultrasound images were used to measure the relative changes in transverse abdominal (TrA), internal oblique (IO) and external oblique (EO) muscle thickness during a simulated weight-bearing ADIM (SWB-ADIM)...
September 6, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28864317/feasibility-and-safety-of-early-repeat-transradial-access-within-30-days-of-previous-coronary-angiography-and-intervention
#18
Alberto E Barria Perez, Olivier Costerousse, Tomas Cieza, Gérald Barbeau, Jean-Pierre Déry, Frédéric Maes, Goran Rimac, Guillaume Plourde, Yann Poirier, Marc-Antoine Carrier, Olivier F Bertrand
Transradial approach (TRA) is the default access site for diagnostic angiography and intervention in many centers. Repeat ipsilateral radial artery access late after index procedure has been associated with failures. It is unknown whether early (≤30 days) and very early (<24 hours) repeat radial access is technically feasible and safe. Study population consisted of consecutive patients undergoing repeat (≥2) procedures within 30 days in a high-volume TRA center. Transradial access failure and resulting femoral approach was categorized as primary (no repeat attempt) or secondary (crossover)...
August 2, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28860472/transferrin-navigation-nano-artificial-antibody-fluorescence-recognition-of-circulating-tumor-cells
#19
Wei Zhang, Jiaoyang Wang, Ping Li, Chuanchen Wu, Hongyan Zhang, Wen Zhang, Hui Wang, Bo Tang
Specific recognition of circulating tumor cells (CTCs) is of great significance for cancer diagnosis and personalized therapy. The antibodies and aptamer are commonly used for recognition of CTCs, but they often suffer from low stability and high cost. Therefore, chemically stable and low-cost artificial recognition elements are still highly demanded. Herein, we prepared nano artificial antibody based on molecular imprinting and applied for fluorescence recognition of CTCs. Surface imprinting was employed to construct a transferrin (TRA)-imprinted layer on the surface of rhodamine doped silica nanoparticles...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845865/-i-meccanismi-di-difesa-e-gli-stili-di-attaccamento-nell-ideazione-paranoide-valutati-in-un-campione-non-clinico-di-giovani-adulti
#20
Giacomo Ciocca, Alberto Collazzoni, Erika Limoncin, Camilla Franchi, Daniele Mollaioli, Giorgio Di Lorenzo, Emiliano Santarnecchi, Alfonso Troisi, Alberto Siracusano, Alessandro Rossi, Emmanuele A Jannini
RIASSUNTO. Obiettivo. L'obiettivo di questa ricerca è stato quello di valutare i meccanismi di difesa e gli stili di attaccamento nell'ideazione paranoide, mediante un disegno di studio cross-sectional con un reclutamento sequenziale di soggetti. Metodi. Cinquecentocinquanta soggetti non-clinici sono stati reclutati tra gli studenti universitari, a cui è stato somministrato un protocollo psicometrico composto da: Symptoms Check List (SCL-90-R-Par), per identificare l'ideazione paranoide; Defence Style Questionnaire (DSQ-40), per valutare i meccanismi di difesa; Relationship Questionnaire (RQ), per misurare gli stili di attaccamento...
July 2017: Rivista di Psichiatria
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