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https://www.readbyqxmd.com/read/28318944/cytotoxic-dammarane-type-triterpenoids-from-the-leaves-of-viburnum-sambucinum
#1
Thanh Tra Nguyen, Bich Ngan Truong, Huong Doan Thi Mai, Marc Litaudon, Van Hung Nguyen, Thao Do Thi, Van Minh Chau, Van Cuong Pham
Four new dammarane-type triterpenoids (1-4) and twelve known compounds (5-16) were isolated from the leaves of Viburnum sambucinum Reinw. ex Blume. Their structures were determined by spectral data analysis, including MS and 2D NMR. Cytotoxic activity evaluation in vitro against four cancer cell lines (KB, LU-1, HepG2 and MCF7) suggested that the octanor-dammarane derivatives were the main cytotoxic components of the leaves of V. sambucinum.
March 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28314288/prevalence-of-cervical-infection-and-genotype-distribution-of-human-papilloma-virus-among-females-in-da-nang-vietnam
#2
Song Nguyen VAN, Minh Nguyen Khac, Jan Dimberg, Andreas Matussek, Anna J Henningsson
AIM: The goal of the present study was to determine the prevalence and distribution of high-risk human papilloma virus (HPV) genotypes in women from two districts in and around Da Nang city, Vietnam. MATERIALS AND METHODS: All participants were randomly selected, 200 from the Hai Chau district and 200 from the Son Tra district. The detection and genotyping of HPV were performed by real-time polymerase chain reaction (PCR) technique. RESULTS: Out of a total of 400 women, we found that 38 (9...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28303528/human-mass-balance-study-and-metabolite-profiling-of-14-c-niraparib-a-novel-poly-adp-ribose-polymerase-parp-1-and-parp-2-inhibitor-in-patients-with-advanced-cancer
#3
Lotte van Andel, Z Zhang, S Lu, V Kansra, S Agarwal, L Hughes, M M Tibben, A Gebretensae, L Lucas, M J X Hillebrand, H Rosing, J H M Schellens, J H Beijnen
Niraparib is an investigational oral, once daily, selective poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor. In the pivotal Phase 3 NOVA/ENGOT/OV16 study, niraparib met its primary endpoint of improving progression-free survival (PFS) for adult patients with recurrent, platinum sensitive, ovarian, fallopian tube, or primary peritoneal cancer in complete or partial response to platinum-based chemotherapy. Significant improvements in PFS were seen in all patient cohorts regardless of biomarker status...
March 16, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28300282/stable-nitrogen-and-carbon-isotopes-in-sediments-and-biota-from-three-tropical-marine-food-webs-application-to-chemical-bioaccumulation-assessment
#4
Hui Zhang, Yun Teng, Tra Thi Thanh Doan, Yun Wei Yat, Sheot Harn Chan, Barry C Kelly
Studies of trophodynamics and contaminant bioaccumulation in tropical marine ecosystems are limited. This study employed stable isotope and trace contaminant analysis to assess sources of primary productivity, trophic interactions and chemical bioaccumulation behavior in two mangrove food webs and one offshore coastal marine food web in Singapore. Samples of sediment, phytoplankton, mangrove leaves, clams, snails, crabs, worms, prawns, and fishes were analyzed for stable carbon and nitrogen isotope values, as well as concentrations of persistent organic pollutants...
March 16, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28293867/binding-specificity-of-r-10g-and-tra-1-60-81-and-substrate-specificity-of-keratanase-ii-studied-with-chemically-synthesized-oligosaccharides
#5
Hiromi Nakao, Yuko Nagai, Aya Kojima, Hidenao Toyoda, Nobuko Kawasaki, Toshisuke Kawasaki
Recently, we established a mouse monoclonal antibody specific to hiPS/ hES cells, R-10G, which recognizes a type of keratan sulfate. Keratan sulfates (KS) comprise a family of glycosaminoglycans consisting of the repeating unit of [Gal-GlcNAc(6S)]. However, there is a diversity in the degree of sulfation at Gal and GlcNAc residues, and also in the mode of linkage, Galβ1 - 3GlcNAc (type 1) or Galβ1 - 4GlcNAc (type 2). To gain more insight into the binding specificity of R-10G, we carried out an ELISA test on avidin-coated plates using polyethylene glycol (PEG)3-biotinylated derivatives of a series of N-acetyllactosamine tetrasaccharides (keratan sulfates (KSs))...
March 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28290380/description-of-coma-and-coma-arousal-therapy-in-caraka-sa%C3%A1-hit%C3%A4-and-its-corollary-in-modern-medicine
#6
Dhaval Shukla
The description of coma and coma arousal therapy in Caraka Saṁhitā is described in sṁtra 24, verses 42-53. It describes the definition of coma, differential diagnosis of coma from other disorders of consciousness, signs of coma, etiology of coma, coma arousal therapy, and emergence from coma. The similarities and differences of these aspects of coma from the perspective of its interpretation in modern medicine are discussed in this article.
March 2017: Neurology India
https://www.readbyqxmd.com/read/28287872/development-of-a-modular-automated-system-for-maintenance-and-differentiation-of-adherent-human-pluripotent-stem-cells
#7
Duncan E Crombie, Maciej Daniszewski, Helena H Liang, Tejal Kulkarni, Fan Li, Grace E Lidgerwood, Alison Conquest, Damian Hernández, Sandy S Hung, Katherine P Gill, Elisabeth De Smit, Lisa S Kearns, Linda Clarke, Valentin M Sluch, Xitiz Chamling, Donald J Zack, Raymond C B Wong, Alex W Hewitt, Alice Pébay
Patient-specific induced pluripotent stem cells (iPSCs) have tremendous potential for development of regenerative medicine, disease modeling, and drug discovery. However, the processes of reprogramming, maintenance, and differentiation are labor intensive and subject to intertechnician variability. To address these issues, we established and optimized protocols to allow for the automated maintenance of reprogrammed somatic cells into iPSCs to enable the large-scale culture and passaging of human pluripotent stem cells (PSCs) using a customized TECAN Freedom EVO...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28287194/-modifiche-morfo-volumetriche-dopo-trattamento-emdr-in-pazienti-drug-na%C3%A3-ve-affetti-da-dpts
#8
Letizia Bossini, Emiliano Santarnecchi, Ilaria Casolaro, Despoina Koukouna, Claudia Caterini, Federica Cecchini, Valentina Fortini, Giampaolo Vatti, Daniela Marino, Isabel Fernandez, Alessandro Rossi, Andrea Fagiolini
RIASSUNTO. Introduzione. Esistono pochi studi che hanno indagato gli effetti di una psicoterapia ritenuta efficace sulle alterazioni strutturali delle regioni cerebrali associate al disturbo da stress post-traumatico (PTSD). Ci siamo, pertanto, proposti di valutare gli effetti neurobiologici della terapia EMDR su un gruppo di 19 pazienti con PTSD, senza cura farmacologica e senza alcuna comorbidità con altri disturbi psichiatrici, a confronto con un gruppo di controllo costituito da 19 soggetti sani non trattati...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28287193/medico-legal-notes-for-a-new-set-of-standards-in-the-assessment-of-penal-liability-in-psychiatry
#9
Gianluca Montanari Vergallo, Raffaella Rinaldi, Giuseppe Bersani, Enrico Marinelli
Negligence liability on the part of a psychiatrist belongs among high-complexity fields, for both the judge and his or her technical consultants. In most instances, there are no scientific grounds in order to ascribe with reasonable certainty liability to medical personnel and nursing staff, while often judges tend to stretch the concept of “protection” to a degree to which the psychiatrist is deemed to have a legal obligation to stave off the development of any adverse consequence which psychic distress may bring upon the patient...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28287192/-libero-arbitrio-neuroscienze-e-scelta-verso-un-modello-basato-sulla-capacit%C3%A3-decisionale-per-la-valutazione-dell-imputabilit%C3%A3
#10
Giovanna Parmigiani, Gabriele Mandarelli, Gerben Meynen, Lorenzo Tarsitani, Massimo Biondi, Stefano Ferracuti
RIASSUNTO. Il libero arbitrio è stato spesso considerato una tematica centrale nella dottrina della responsabilità criminale. Ciononostante, il concetto stesso di libero arbitrio presenta intrinseche problematiche nella sua definizione teorica e applicazione pratica in un contesto clinico/forense ed è intensamente dibattuto. Nello specifico, l'esistenza stessa del libero arbitrio è stata recentemente posta in discussione anche sulla base di alcune evidenze sperimentali neuroscientifiche. Questo dibattito ha implicazioni significative in quei campi in cui l'associazione tra libertà di scelta è comportamento costituisce il focus di interesse, quali la psichiatria forense...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28277861/state-transition-model-vorapaxar-added-to-standard-antiplatelet-therapy-to-prevent-thrombosis-post-myocardial-infarction-or-peripheral-artery-disease
#11
Mark Du, Monica Chase, Mustafa Oguz, Glenn Davies
OBJECTIVE: To evaluate long-term health benefits and risks of adding vorapaxar (VOR) to the standard care antiplatelet therapy (SC) of aspirin and/or clopidogrel, among a population with a recent myocardial infarction (MI) and/or peripheral artery disease (PAD). RESEARCH DESIGN AND METHODS: In a state-transition model, patients transition between health states (event-free, recurrent MI, stroke, death), while at risk of experiencing non-transition-related revascularization and non-fatal bleeding events...
March 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28266262/using-exposure-bands-for-rapid-decision-making-in-the-risk21-tiered-exposure-assessment
#12
M Dellarco, R Zaleski, B J Gaborek, H Qian, C A Bellin, P Egeghy, N Heard, O Jolliet, D R Lander, N Sunger, K S Stylianou, J Y Tanir
The ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment in the Twenty-first Century (RISK21) project was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent evaluation of both hazard and exposure components. The RISK21 roadmap is exposure-driven, that is, exposure is used as the second step (after problem formulation) to define and focus the assessment...
February 10, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28266021/gingival-spheroids-possess-multilineage-differentiation-potential
#13
Rajasekaran Subbarayan, Dinesh Murugan Girija, Suresh Ranga Rao
Recently studies have demonstrated HGMSCs as ideal candidates for regenerative study. Interestingly we found that HGMSCs derived spheroids are more potent and maintain the properties of stemness convincingly compared to conventional culture methods. During the culture, GMSCs instinctively accumulated into spheroids and display multipotent STRO-1 and Vimentin-positive cells. Reduced phenotypic expression of CD73, CD105 and, elevated expression STRO-1 and CD-34. Pluripotent nature of S-GMSCs putatively shown the expression of OCT4A, NANOG, SOX-2, SSEA4, TRA-1-60, and TRA-181...
March 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28250775/preferential-lineage-specific-differentiation-of-osteoblast-derived-induced-pluripotent-stem-cells-into-osteoprogenitors
#14
Casey L Roberts, Silvia S Chen, Angela C Murchison, Rebecca A Ogle, Michael P Francis, Roy C Ogle, Patrick C Sachs
While induced pluripotent stem cells (iPSCs) hold great clinical promise, one hurdle that remains is the existence of a parental germ-layer memory in reprogrammed cells leading to preferential differentiation fates. While it is problematic for generating cells vastly different from the reprogrammed cells' origins, it could be advantageous for the reliable generation of germ-layer specific cell types for future therapeutic use. Here we use human osteoblast-derived iPSCs (hOB-iPSCs) to generate induced osteoprogenitors (iOPs)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28217414/dance-balance-and-core-muscle-performance-measures-are-improved-following-a-9-week-core-stabilization-training-program-among-competitive-collegiate-dancers
#15
Todd Watson, Jessica Graning, Sue McPherson, Elizabeth Carter, Joshuah Edwards, Isaac Melcher, Taylor Burgess
BACKGROUND: Dance performance requires not only lower extremity muscle strength and endurance, but also sufficient core stabilization during dynamic dance movements. While previous studies have identified a link between core muscle performance and lower extremity injury risk, what has not been determined is if an extended core stabilization training program will improve specific measures of dance performance. HYPOTHESIS/PURPOSE: This study examined the impact of a nine-week core stabilization program on indices of dance performance, balance measures, and core muscle performance in competitive collegiate dancers...
February 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28216321/effects-of-dmso-on-a-rabbit-ear-hypertrophic-scar-model-a-controlled-randomized-experimental-study
#16
Elif Sari, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yildiran
Dimethyl sulfoxide (DMSO) is an anti-inflammatory, antibacterial, analgesic drug widely used to treat several diseases as reported in the literature. It has a detractive effect on collagen deposition in the abnormal tissue. This study aimed to investigate the possible therapeutic effects of DMSO on hypertrophic scar formation in rabbits. Twenty-four New Zealand male albino rabbits were randomly divided into four groups: control, sham, DMSO, and TRA (triamcinolone acetonide). Except the control group, punch biopsy defects were created on each animal's right ear...
April 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28216229/trans-ulnar-catheterization-and-coronary-interventions-from-technique-to-outcomes
#17
REVIEW
Sudhakar Sattur, Maninder Singh, Edo Kaluski
The ulnar artery is similar in size to the radial artery, however it is more difficult to palpate and access. For those physicians who mastered trans-ulnar access (TUA) this access site serves as an alternative to trans radial access (TRA) when the radial artery access is rendered suboptimal (by palpation, ultrasound examination or previous procedural records) or when encountering TRA difficulties or failure. The manuscript describes the anatomy, suggested technique, procedural success and complications associated with TUA...
February 1, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28215675/basic-fibroblast-growth-factor-is-critical-to-reprogramming-buffalo-bubalus-bubalis-primordial-germ-cells-into-embryonic-germ-stem-cell-like-cells
#18
Caizhu Wang, Yanfei Deng, Feng Chen, Peng Zhu, Jingwei Wei, Chan Luo, Fenghua Lu, Sufang Yang, Deshun Shi
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major signaling pathways and culture media involved in this derivation remain unclear. Here, the effects of basic fibroblast growth factor (bFGF) and downstream signaling pathways on the reprogramming of buffalo PGCs into EG-like cells were investigated. Results showed bFGF to be critical to buffalo PGCs to dedifferentiate into EG-like cells (20 ng/mL is optimal) with many characteristics of pluripotent stem cells, including alkaline phosphatase (AP) activity, expression of pluripotency marker genes such as OCT4, NANOG, SOX2, SSEA-1, CDH1, and TRA-1-81, and the capacity to differentiate into all three embryonic germ layers...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28210447/the-effect-of-different-insertion-techniques-on-the-depth-of-cure-and-vickers-surface-micro-hardness-of-two-bulk-fill-resin-composite-materials
#19
Lamiaa-Mahmoud Moharam, Ahmed-Zohair El-Hoshy, Karim Abou-Elenein
BACKGROUND: The aim of this study was to evaluate the Vickers surface micro-hardness and the depth of cure of two bulk-fill resin composites and one incremental-fill resin composite. MATERIAL AND METHODS: Two Bulk-fill dental resin composites (X-tra Fil, Voco; Sonic-FillTM 2, Kerr Corporation) and an incremental-fill dental resin composite (Filtek™ Z250 XT, 3M ESPE) were used. Sixty cylindrical specimens of 4 mm thickness were prepared using split Teflon moulds...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208678/novel-fingertip-image-based-heart-rate-detection-methods-for-a-smartphone
#20
Rifat Zaman, Chae Ho Cho, Konrad Hartmann-Vaccarezza, Tra Nguyen Phan, Gwonchan Yoon, Jo Woon Chong
We hypothesize that our smartphone-based fingertip image-based heart rate detection methods reliably detect the heart rhythm and rate of subjects. We propose fingertip curve line movement-based and fingertip image intensity-based detection methods, which both use the movement of successive fingertip images obtained from smartphone cameras. To investigate the performance of the proposed methods, heart rhythm and rate of the proposed methods are compared to those of the conventional method, which is based on average image pixel intensity...
February 12, 2017: Sensors
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