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https://www.readbyqxmd.com/read/26240808/extragastroesophageal-malignancy-associated-secondary-achalasia-a-rare-association-of-pancreatic-cancer-rendering-alarm-manifestation
#1
Hong Min Kim, Ji Min Chu, Won Hee Kim, Sung Pyo Hong, Ki Baik Hahm, Kwang Hyun Ko
Secondary achalasia or pseudoachalasia is a rare esophageal motor abnormality, which mimics primary achalasia; it is not easily distinguishable from idiopathic achalasia by manometry, radiological examination, or endoscopy. Although the majority of reported pseudoachalasia cases are associated with neoplasms at or near the esophagogastric (EG) junction, other neoplastic processes or even chronic illnesses such as rheumatoid arthritis can lead to the development of pseudoachalasia, for example, mediastinal masses, gastrointestinal (GI) tumors of the liver and biliary tract, and non-GI malignancies...
July 2015: Clinical Endoscopy
https://www.readbyqxmd.com/read/23374644/the-potential-prognostic-value-of-connexin-26-and-46-expression-in-neoadjuvant-treated-breast-cancer
#2
Ivett Teleki, Tibor Krenacs, Marcell A Szasz, Janina Kulka, Barna Wichmann, Cornelia Leo, Barbel Papassotiropoulos, Cosima Riemenschnitter, Holger Moch, Zsuzsanna Varga
BACKGROUND: Several classification systems are available to assess pathological response to neoadjuvant chemotherapy in breast cancer, but reliable biomarkers to predict the efficiency of primary systemic therapy (PST) are still missing. Deregulation of gap junction channel forming connexins (Cx) has been implicated in carcinogenesis and tumour progression through loss of cell cycle control. In this study we correlated Cx expression and cell proliferation with disease survival and pathological response to neoadjuvant chemotherapy in breast cancers using existing classification systems...
2013: BMC Cancer
https://www.readbyqxmd.com/read/23267993/-a-case-of-barrett-s-esophageal-carcinoma-treated-with-combined-therapy
#3
Yujin Suto, Naoki Tomizawa, Tatsumasa Andoh, Kazuhisa Arakawa, Katsumi Kobayashi, Hiroaki Sato, Kazuha Sakamoto, Hideaki Itoh, Yutaka Sunose, Izumi Takeyoshi
During a routine health examination, a 50-year-old man was found to have an elevated lesion at the esophagogastric junction. Poorly differentiated adenocarcinoma was diagnosed from the biopsy findings. Computed tomography showed metastases in the mediastinal, intra-abdominal, and paraaortic lymph nodes. The clinical stage diagnosis was cT2, cN4, cM0, cStage IVa. Combination chemotherapy with docetaxel, CDDP, and 5-FU (DCF) was started initially. After 2 courses of DCF, the primary lesion and mediastinal lymph nodes had decreased in size, but the intra-abdominal lymph node had grown...
November 2012: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/23254690/postchemoradiation-resected-locally-advanced-esophageal-and-gastroesophageal-junction-carcinoma-long-term-outcome-with-or-without-intraoperative-radiotherapy
#4
Felipe A Calvo, Claudio V Sole, Rosángela Obregón, Marina Gómez-Espí, Miguel A Lozano, Luis Gonzalez-Bayon, Jose Luis García-Sabrido
BACKGROUND: To report feasibility, tolerance, anatomical topography of locoregional recurrence (LRR), and long-term outcome for esophageal and esophagogastric (EG) cancer patients treated with preoperative chemoradiation (CRT) and surgery with or without a radiation boost of intraoperative electron beam radiotherapy (IOERT). METHODS: From January 1995 to December 2010, 53 patients with primary esophageal (n = 26; 44 %) or EG carcinoma (n = 30; 56 %), and disease confined to locoregional area [clinical stage: IIb (n = 30; 57 %), IIIa (n = 14; 26 %), IIIb (n = 6; 11 %), IIIc (n = 3; 6 %)], were treated with preoperative CRT, curative (R0) resection with an extended (two-field) lymph node dissection in all cases...
June 2013: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/22076207/evaluation-of-the-7th-uicc-tnm-staging-system-of-gastric-cancer
#5
Sung Joon Kwon
Since January of 2010, the seventh edition of UICC tumor node metastasis (TNM) Classification, which has recently been revised, has been applied to almost all cases of malignant tumors. Compared to previous editions, the merits and demerits of the current revisions were analyzed. Many revisions have been made for criteria for the classification of lymph nodes. In particular, all the cases in whom the number of lymph nodes is more than 7 were classified as N3 without being differentiated. Therefore, the coverage of the N3 was broad...
June 2011: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/21406386/alcohol-intake-and-risk-of-oesophageal-adenocarcinoma-a-pooled-analysis-from-the-beacon-consortium
#6
MULTICENTER STUDY
Neal D Freedman, Liam J Murray, Farin Kamangar, Christian C Abnet, Michael B Cook, Olof Nyrén, Weimin Ye, Anna H Wu, Leslie Bernstein, Linda M Brown, Mary H Ward, Nirmala Pandeya, Adele C Green, Alan G Casson, Carol Giffen, Harvey A Risch, Marilie D Gammon, Wong-Ho Chow, Thomas L Vaughan, Douglas A Corley, David C Whiteman
BACKGROUND AND AIMS: Alcohol intake is a strong and well established risk factor for oesophageal squamous cell carcinoma (OSCC), but the association with oesophageal adenocarcinoma (OA) or adjacent tumours of the oesophagogastric junction (OGJA), remains unclear. Therefore, the association of alcohol intake with OSCC, OA, and OGJA was determined in nine case-control studies and two cohort studies of the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium (BEACON). MATERIALS AND METHODS: Information was collected on alcohol intake, age, sex, education, body mass index, gastro-oesophageal reflux, and tobacco smoking from each study...
August 2011: Gut
https://www.readbyqxmd.com/read/19660401/survival-of-patients-with-distal-esophageal-and-gastric-cardia-tumors-a-population-based-analysis-of-gastroesophageal-junction-carcinomas
#7
Bryan A Whitson, Shawn S Groth, Zhongze Li, Robert A Kratzke, Michael A Maddaus
OBJECTIVE: Distal esophageal tumors and gastric cardia tumors, although only physically separated by centimeters, have different staging systems and are usually treated differently. We hypothesized that gastroesophageal junction adenocarcinomas (eg, gastric cardia and distal esophageal tumors) were not distinct entities and had similar survival. METHODS: Using the Surveillance, Epidemiology, and End Results database (1988-2005), we identified patients with adenocarcinomas of the distal esophagus (n = 1474) and gastric cardia (n = 192)...
January 2010: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/17023973/esophageal-cancer
#8
T Lerut, G Decker
Carcinoma of the esophagus and gastroesophageal junction continues to be an aggressive cancer with poor prognosis, despite improved surgical results and the potential benefit of combined multimodality regimens. Additional data seem to confirm the rising incidence of adenocarcinoma, although users of nonsteroidal anti-inflammatory drugs seem to have a decreased risk. Much attention is focused on detecting high-grade dysplasia and early carcinoma with promising results using red fluorescence after preceding 5-aminolevulinic acid (ALA) sensitization...
July 1999: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/16167708/staple-ethiopian-diet-and-cancer-of-the-oesophagus
#9
B Mengesha, W Ergete
BACKGROUND: Previous reports from Ethiopia suggest that oesophageal cancers are due to thermal injury of hot food and beverages. However, in most other countries diet plays an important role. OBJECTIVES: To investigate the association of diet and incidence of carcinoma of oesophagus in Ethiopia. DESIGN: A prospective study. SETTING: All adult patients, who were either referred or self referred from other health institutions, were investigated in Mexico Higher Clinic, Addis Ababa, Ethiopia...
July 2005: East African Medical Journal
https://www.readbyqxmd.com/read/12718583/prevention-of-endometrial-cancer-in-breast-cancer-patients-taking-tamoxifen-the-gynecologists-role
#10
Supat Sinawat
Breast cancer is among the commonest malignant diseases in women. Over the past two decades tamoxifen has been generally accepted as an endocrine therapy of choice for prevention of breast cancer recurrence. Although tamoxifen was thought to have only a few adverse effects, several reports indicate that it is associated with an increase incidence of proliferative and neoplastic changes in the endometrium, with a 1.3 to 7.5 relative risk of developing endometrial carcinoma. The increased risk of endometrial cancer following the use of tamoxifen has stimulated studies on endometrial diagnostic screening methods...
2002: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/12424856/transthoracic-or-transhiatal-esophagectomy-for-cancer-of-the-esophagus-does-it-matter
#11
REVIEW
John S Bolton, Steve Teng
Despite the ongoing controversy between proponents of TTE and THE, in the hands of experienced surgeons, both approaches provide excellent results for patients with carcinoma of the esophagus and EG junction. Ideally, surgeons dealing with esophageal carcinoma should be expert in both approaches and should select the best approach for the individual patient. The transhiatal approach appears to have a slightly lower operative mortality, and this advantage may be significant for the older, higher-risk surgical patient...
April 2002: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/11781220/proteins-encoded-by-genes-involved-in-chromosomal-alterations-in-lymphoma-and-leukemia-clinical-value-of-their-detection-by-immunocytochemistry
#12
REVIEW
Brunangelo Falini, David Y Mason
Acquired chromosomal anomalies (most commonly translocations) in lymphoma and leukemia usually result in either activation of a quiescent gene (by means of immunoglobulin or T-cell-receptor promotors) and expression of an intact protein product, or creation of a fusion gene encoding a chimeric protein. This review summarizes current immunocytochemical studies of these 2 categories of oncogenic protein, with emphasis on the clinical relevance of their detection in diagnostic samples. Among the quiescent genes activated by rearrangement, expression of cyclin D1 (due to rearrangement of the CCND1 [BCL-1] gene) is a near-specific marker of t(11;14) in mantle cell lymphoma; BCL-2 expression distinguishes follicular lymphoma cells from their nonneoplastic counterparts in reactive germinal centers and appears to be an independent prognostic marker in diffuse large cell lymphoma; and TAL-1 (SCL) expression identifies T-cell acute lymphoblastic neoplasms in which this gene is activated...
January 15, 2002: Blood
https://www.readbyqxmd.com/read/11110945/nonenhanced-helical-ct-and-us-in-the-emergency-evaluation-of-patients-with-renal-colic-prospective-comparison
#13
COMPARATIVE STUDY
D H Sheafor, B S Hertzberg, K S Freed, B A Carroll, M T Keogan, E K Paulson, D M DeLong, R C Nelson
PURPOSE: To compare nonenhanced helical computed tomography (CT) with ultrasonography (US) for the depiction of urolithiasis. MATERIALS AND METHODS: During 9 months, 45 patients (mean age, 44 years; mean weight, 92.5 kg) prospectively underwent both nonenhanced helical CT (5-mm collimation; pitch of 1.5) and US of the kidneys, ureters, and bladder. US evaluation included a careful search for ureteral calculi. Presence of calculi and obstruction and incidental diagnoses were recorded...
December 2000: Radiology
https://www.readbyqxmd.com/read/10197195/barrett-s-oesophagus
#14
REVIEW
R M Navaratnam, M C Winslet
Barrett's oesophagus represents the replacement of stratified squamous epithelium by metaplastic columnar epithelium for 3 cm of the distal oesophagus. Gastro-oesophageal reflux, which affects 40% of the adult population, is the principal aetiological factor. This results in predominantly acid but also bile reflux (due to duodenogastrooesophageal reflux) through the lower oesophageal sphincter, transient relaxation of which accounts for the main mechanism of reflux. Conventional Barrett's oesophagus is reported in 11-13% of patients with symptomatic reflux and short segment Barrett's oesophagus (< 3...
November 1998: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/8611986/role-of-esophagogastroscopy-in-application-and-follow-up-of-high-dose-rate-brachytherapy-hdrb-for-treatment-of-esophageal-carcinoma
#15
F L Greene, R J Boulware, J Bianco
Flexible esophagogastroscopy (EG) and external beam radiotherapy (EBR) have become important means of diagnosing and treating both squamous and adenocarcinoma of the esophagus and gastroesophageal (GE) junction. Recently, new technology, termed high-dose-rate brachytherapy (HDRB), utilizing the placement of radioisotopes in the esophagus by endoscopic techniques has been introduced. This report describes the endoscopic application of the brachytherapy afterloading catheters and the additional role of EG in the posttreatment assessment of these patients...
December 1995: Surgical Laparoscopy & Endoscopy
https://www.readbyqxmd.com/read/8413552/-obtaining-an-adequate-pap-cell-test
#16
C E Muller
Routine use of the Papanicolaou (Pap) smear has led to a decrease in mortality from cervical carcinoma. The Papanicolaou test examines exfoliated cells to detect preinvasive lesions (eg, dysplasia, carcinoma-in-situ) as well as invasive lesions. Cervical screening is recommended for women who are sexually active regardless of age. For the woman who is not sexually active, cervical screening should begin at 18 years of age. An essential part of a good Pap smear technique is that the specimen should consist of cells from the squamocolumnar junction...
June 1993: Nursing RSA, Verpleging RSA
https://www.readbyqxmd.com/read/7621410/cytogenetics-of-gastric-and-esophageal-adenocarcinomas-3q-deletion-as-a-possible-primary-chromosomal-change
#17
P H Rao, S Mathew, D P Kelsen, R S Chaganti
We report clonal chromosome abnormalities in short term cultures of seven gastric or esophageal adenocarcinomas and two squamous carcinomas of the esophagus and EG junction. The most consistent aberration encountered was a del(3) (q13.2q23) seen in six of nine tumors. This finding, together with a survey of published cytogenetic literature, suggested that del(3q) is the most common cytogenetic abnormality, and hence possibly of primary significance, in these tumors. In addition to del(3q), rearrangements affecting 1p13 (two cases), 6q15-q23 (two cases), 7p22 (two cases), 7q22 (two cases), and 11p11...
June 1995: Cancer Genetics and Cytogenetics
https://www.readbyqxmd.com/read/6896982/peutz-jeghers-syndrome-with-metastasizing-gastric-adenocarcinoma-report-of-a-case
#18
COMPARATIVE STUDY
R E Halbert
A case of metastatic, poorly differentiated gastric adenocarcinoma in a 22-year-old woman with Peutz-Jeghers syndrome was studied. The young age of many patients who have gastrointestinal (GI) carcinoma associated with this syndrome, as well as the unusual locations of primary tumors (eg, duodenum), suggest an increased tendency toward malignant transformation in the upper Gl tract. Statistical support of this contention, however, is unavailable from presently available data.
October 1982: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/3548408/desmosomal-plaque-associated-vimentin-filaments-in-human-ovarian-granulosa-cell-tumors-of-various-histologic-patterns
#19
B Czernobilsky, R Moll, G Leppien, G Schweikhart, W W Franke
Proteins of intermediate-sized filaments and desmosomal plaques (desmoplakins) of four human ovarian granulosa cell tumors were studied by immunofluorescence and immunoelectron microscopy and by two-dimensional gel electrophoresis of microdissected tissue samples. All tumor cells, irrespective of their specific histologic patterns, contained both vimentin and desmoplakins. Cytokeratin-positive structures were absent or very scant in most tumor regions, but more common in trabecular, insular, macro- and microfollicular structures...
March 1987: American Journal of Pathology
https://www.readbyqxmd.com/read/2586415/-radical-operation-for-carcinoma-of-gastric-cardia-lymph-node-dissection-by-laparosternophrenotomy-approach
#20
M Kitamura, K Arai, T Yoshikawa, G Kosaki, Y Awane
The adequate esophago-gastric resection and lymph node dissection can be performed without the necessity of a thoracotomy, by using the laparosternophrenotomy approach. For tumors restricted to lower esophagus of 4cm in localized tumors or 3cm in invaded tumors above the EG junction, the sternotomy approach is utilized. However, if the tumor extends to more than the above criteria, the thoracoabdominal approach must be utilized. For 14 years, 85 cases with tumor of gastric cardia were performed by sternotomy approach and 76 cases were performed by thoracotomy approach...
September 1989: Nihon Geka Gakkai Zasshi
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