Yimeng Sun, Fan Li, Yunfei Liu, Dijie Qiao, Xinyu Yao, Guei-Sheung Liu, Dequan Li, Chuanle Xiao, Tao Wang, Wei Chi
Retinal diseases encompass various conditions associated with sight-threatening immune responses and are leading causes of blindness worldwide. These diseases include age-related macular degeneration, diabetic retinopathy, glaucoma and uveitis. Emerging evidence underscores the vital role of the innate immune response in retinal diseases, beyond the previously emphasized T-cell-driven processes of the adaptive immune system. In particular, pyroptosis, a newly discovered programmed cell death process involving inflammasome formation, has been implicated in the loss of membrane integrity and the release of inflammatory cytokines...
April 22, 2024: Progress in Retinal and Eye Research