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https://www.readbyqxmd.com/read/28812832/exploring-the-functioning-of-decision-space-a-review-of-the-available-health-systems-literature
#1
REVIEW
Tamlyn Eslie Roman, Susan Cleary, Diane McIntyre
BACKGROUND: The concept of decision space holds appeal as an approach to disaggregating the elements that may influence decision-making in decentralized systems. This narrative review aims to explore the functioning of decision space and the factors that influence decision space. METHODS: A narrative review of the literature was conducted with searches of online databases and academic journals including PubMed Central, Emerald, Wiley, Science Direct, JSTOR, and Sage...
February 27, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28811953/from-inflammation-to-current-and-alternative-therapies-involved-in-wound-healing
#2
REVIEW
Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges
Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811745/inhibition-of-inflammation-mediated-through-the-tumor-necrosis-factor-%C3%AE-biochemical-pathway-can-lead-to-favorable-outcomes-in-alzheimer-disease
#3
REVIEW
Daniah Shamim, Michael Laskowski
Tumor necrosis factor α (TNF-α) inhibitors have long been used as disease-modifying agents in immune disorders. Recently, research has shown a role of chronic neuroinflammation in the pathophysiology of neurodegenerative diseases such as Alzheimer disease, and interest has been generated in the use of anti-TNF agents and TNF-modulating agents for prevention and treatment. This article extensively reviewed literature on animal studies testing these agents. The results showed a role for direct and indirect TNF-α inhibition through agents such as thalidomide, 3,6-dithiothalidomide, etanercept, infliximab, exendin-4, sodium hydrosulfide, minocycline, imipramine, and atorvastatin...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28811049/marijuana-and-cannabinoids-in-esrd-and-earlier-stages-of-ckd
#4
Joshua L Rein, Christina M Wyatt
Marijuana is the most commonly used recreational drug in the United States, and legal recreational and medicinal use has gained public acceptance during the last decade. Twenty-nine US states have established medical marijuana programs, 8 of which have also legalized recreational marijuana, and Canada is expected to legalize recreational marijuana in 2018. Advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) are chronic conditions with significant associated morbidity and mortality. Patients experience substantial symptom burden that is frequently undertreated due to adverse medication side effects...
August 12, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28811039/twenty-years-of-staffing-practice-environment-and-outcomes-research-in-military-nursing
#5
Patricia A Patrician, Lori A Loan, Mary S McCarthy, Pauline Swiger, Sara Breckenridge-Sproat, Laura Ruse Brosch, Bonnie Mowinski Jennings
BACKGROUND: Two decades ago, findings from an Institute of Medicine (IOM) report sparked the urgent need for evidence supporting relationships between nurse staffing and patient outcomes. PURPOSE: This article provides an overview of nurse staffing, practice environment, and patient outcomes research, with an emphasis on findings from military studies. Lessons learned also are enumerated. METHOD: This study is a review of the entire Military Nursing Outcomes Database (MilNOD) program of research...
July 10, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28810967/improving-awareness-of-behavioral-health-readiness
#6
Justin M Curley, Christopher H Warner
INTRODUCTION: Readiness for worldwide deployments as force structure decreases is of vital importance to our military. Advances in access and efforts to decrease stigma for behavioral health (BH) treatment has impacted unit readiness levels. However, concern exists that there are still a significant number of service members with behavioral health conditions who are unable to deploy. This article outlines the current state of behavioral health readiness in one U.S. Army Division and provides a programmatic review of a systems based initiative, the Behavioral Health Readiness Tool (BHRT), designed to enhance awareness of current levels...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810947/intravaginal-delivery-approaches-for-contraception-an-overview-with-emphasis-on-gels
#7
Sonia Gupta, Vijay Prabha
The rising population with grave ramifications for the future is a fundamental issue, demanding for newer and better contraceptive modalities. Also, in order to achieve the contraceptive purpose, the choice of the most suitable delivery system is of unquestionable importance. Out of all dosage forms, vaginal gel formulations present indubitable benefits for contraceptive administration. Therefore, this review summarizes the history of research in the field of vaginal delivery systems with special emphasis on the development of vaginal gels containing safer and more effective contraceptive agents...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28810528/neuroprotection-of-bradykinin-bradykinin-b2-receptor-system-in-cerebral-ischemia
#8
REVIEW
Bingyuan Ji, Baohua Cheng, Yanyou Pan, Chunmei Wang, Jing Chen, Bo Bai
Bradykinin B2 receptor (B2R) activated by its endogenous ligand bradykinin participates in various physiological processes including neurogenesis, neuronal differentiation, and control of inflammation and blood pressure. Besides these effects, B2R has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury. Here, we highlight the mechanisms of BK/B2R-mediated neuroprotective effects in the peripheral and central nervous systems. Moreover, this review article summarizes some of the signaling pathways of B2R in cerebral ischemia, leading to a better understanding of its neuroprotection...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28809060/the-phytochemistry-and-pharmacology-of-butia-sp-a-systematic-review-and-an-overview-of-the-technological-monitoring-process
#9
REVIEW
Lara Rodrigues Schneider, Daniela Coelho Dos Santos, Angela Diniz Campos, Rafael Guerra Lund
The Butia sp. are native South America trees, whose fruits are consumed in natura and have significant biological properties; however, trees of this genus plant are in danger of extinction. A systematic review of the literature and a technological overview were carried out to summarize the available evidence on the therapeutic uses and the phytochemical compounds of Butia sp. The following electronic databases were researched: MedLine (PubMed), Web of Science, Scopus, Scielo, and the gray literature. Furthermore, the online system such as the US Patent and Trademark Office, Espacenet, National Institute of Industrial Property, and Google Patents were accessed to obtain patent data...
August 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28808881/a-proposal-to-detect-the-double-submission-of-a-manuscript-sent-for-review
#10
Manjur Kolhar, Abdalla Alameen, Safar Bin Bkhit AlMudara
Along with the rapid growth of editorial systems and publishers, the number of research articles is increasing, which creates a need for an effective dissemination strategy. Researchers commonly use editorial systems in a candid manner. However, when researchers concurrently submit the same contribution in more than one editorial system, it is considered unethical. In this paper, we propose a novel approach called DeMSum for detecting such duplicate submissions. DeMSum verifies a manuscript (MS) by processing the MS attributes that are accessed through the editorial system...
August 14, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28808657/nanoparticulate-tubular-immunostimulating-complexes-novel-formulation-of-effective-adjuvants-and-antigen-delivery-systems
#11
REVIEW
Nina Sanina, Natalia Chopenko, Andrey Mazeika, Eduard Kostetsky
New generation vaccines, based on isolated antigens, are safer than traditional ones, comprising the whole pathogen. However, major part of purified antigens has weak immunogenicity. Therefore, elaboration of new adjuvants, more effective and safe, is an urgent problem of vaccinology. Tubular immunostimulating complexes (TI-complexes) are a new type of nanoparticulate antigen delivery systems with adjuvant activity. TI-complexes consist of cholesterol and compounds isolated from marine hydrobionts: cucumarioside A2-2 (CDA) from Cucumaria japonica and monogalactosyldiacylglycerol (MGDG) from marine algae or seagrass...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28807210/personalized-treatment-in-patients-with-colorectal-liver-metastases
#12
Dimitrios Moris, Timothy M Pawlik
BACKGROUND: Precision Medicine Initiative is a new research effort aiming to offer personalized treatment in many diseases, including cancer. The aim of the present article is to offer novel insights about the role of personalized treatment in patients with colorectal liver metastases (CRLM). METHODS: A review of the literature regarding personalized medicine and colorectal liver metastases was performed mainly in the MEDLINE/PubMed database. RESULTS: Surgical resection remains the only hope for cure of CRLM...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28807107/etiologies-and-management-of-cutaneous-flushing-nonmalignant-causes
#13
REVIEW
Azeen Sadeghian, Hailey Rouhana, Brittany Oswald-Stumpf, Erin Boh
The flushing phenomenon may represent a physiologic or a pathologic reaction. Although flushing is usually benign, it is prudent that the physician remains aware of potentially life-threatening conditions associated with cutaneous flushing. A thorough investigation should be performed if the flushing is atypical or not clearly associated with a benign underlying process. The diagnosis often relies on a pertinent history, review of systems, physical examination, and various laboratory and imaging modalities, all of which are discussed in the 2 articles in this continuing medical education series...
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28805961/reducing-branded-prescription-drug-prices-a-review-of-policy-options
#14
G Caleb Alexander, Jeromie Ballreich, Mariana P Socal, Taruja Karmarkar, Antonio Trujillo, Jeremy Greene, Joshua Sharfstein, Gerard Anderson
The high prices of specialty pharmaceuticals are causing some public programs to ration care and many private insurers, including Medicare drug plans, to place specialty drugs on high cost sharing tiers. As a result, access to these drugs is severely restricted, and only a small portion of the population with the disease is receiving treatment. This concern has generated a wide range of proposed solutions. We conducted a literature review and identified fifty-two solutions in the peer reviewed literature that we classified into five broad categories: revising the patent system; encouraging research to increase development of new drugs; altering pharmaceutical regulation; decreasing market demand; and developing innovative pricing strategies...
August 14, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28805937/new-data-on-hyperpigmentation-disorders
#15
REVIEW
S Schalka
Recently visible light (VL) and vascularization triggered by infrared light (IR) play a role in hyperpigmentation disorders of the skin. The aim of this article is to provide an update on the aetiology of hyperpigmentation disorders and means of prevention against UV, visible (VL) and infrared light (IR). The author conducted a literature review of the most recent data about hyperpigmentation disorders and means of prevention and protection. VL impacts on pigmentation, especially in individuals with phototype III, IV or V and also causes the production of Reactive Oxygen Species (ROS), erythema and DNA damage through ROS production as well as photodermatoses...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28805542/plasma-protein-adsorption-and-biological-identity-of-systemically-administered-nanoparticles
#16
Dongyu Chen, Shanthi Ganesh, Weimin Wang, Mansoor Amiji
Although a variety of nanoparticles (NPs) have been used for drug delivery applications, their surfaces are immediately covered by plasma protein corona upon systemic administration. As a result, the adsorbed proteins create a unique biological identity of the NPs that lead to unpredictable performance. The protein corona on NPs could also impede active targeting, induce off-target effects, trigger particle clearance and even provoke toxicity. This article reviews the fundamentals of NP-plasma protein interaction, the consequences of the interactions, and provides insights into the correlations of protein corona with biodistribution and cellular delivery...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28805403/where-s-the-lgbt-in-integrated-care-research-a-systematic-review
#17
Rachel L Hughes, Catherine Damin, Katie Heiden-Rootes
INTRODUCTION: Lesbian, gay, bisexual, and transgender (LGBT) individuals experience more negative health outcomes compared with their heterosexual peers. The health disparities are often related to family and social rejection of the LGBT individuals. Integrated care, and Medical Family Therapy in particular, may aid in addressing the systemic nature of the negative health outcomes. METHOD: To better understand the current state of the integrated care literature on addressing the health needs of LGBT individuals, a systematic review of the research literature was conducted from January 2000 to January 2016 for articles including integrated health care interventions for LGBT populations...
August 14, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28805354/microbial-ecology-based-engineering-of-microbial-electrochemical-technologies
#18
REVIEW
Christin Koch, Benjamin Korth, Falk Harnisch
Microbial ecology is devoted to the understanding of dynamics, activity and interaction of microorganisms in natural and technical ecosystems. Bioelectrochemical systems represent important technical ecosystems, where microbial ecology is of highest importance for their function. However, whereas aspects of, for example, materials and reactor engineering are commonly perceived as highly relevant, the study and engineering of microbial ecology are significantly underrepresented in bioelectrochemical systems...
August 14, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28805255/mandibular-complete-denture-versus-single-implant-overdenture-a-systematic-review-of-patient-reported-outcomes
#19
REVIEW
Túlio Eduardo Nogueira, Danilo Rocha Dias, Cláudio Rodrigues Leles
The single-implant mandibular overdenture (SIMO) has been proposed as an alternative for edentulous patients who are poorly adapted to their dentures due to low retention and stability of the conventional mandibular complete denture (CD). However, there is a lack of evidence regarding the effectiveness of SIMO, which can be measured by examining patient perception of treatment effects. The aim of this systematic review was to assess the comparative results of CD and SIMO treatments by using patient-reported outcome measures...
August 14, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28805140/a-rat-model-for-the-in-vivo-assessment-of-biological-and-tissue-engineered-valvular-and-vascular-grafts
#20
Yukiharu Sugimura, Anna Kathrin Schmidt, Artur Lichtenberg, Alexander Assmann, Payam Akhyari
The demand for an improvement of the biocompatibility and durability of vascular and valvular implants requires translational animal models to study the in vivo fate of cardiovascular grafts. In the present article, a review on the development and application of a microsurgical rat model of infrarenal implantation of aortic grafts and aortic valved conduits is provided. By refinement of surgical techniques and inclusion of hemodynamic considerations, a functional model has been created, which provides a modular platform for the in vivo assessment of biological and tissue-engineered grafts...
August 12, 2017: Tissue Engineering. Part C, Methods
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